Universitat Leipzig Patent applications |
Patent application number | Title | Published |
20150285814 | PHOSPHORESCENT DYE AND PHOSPHORESCENCE IMMUNOASSAY BY PEPTIDE DISPLACEMENT - The present invention relates to a method for preparation of a 2-chloro-1,10-phenanthrolinamine, comprising the steps: i) conversion of a 2-chloro-1,10-phenanthroline to a 2-chloro-nitro-1,10-phenanthroline characterized by a formula 2, j) hydrogenation of said 2-chloro-nitro-1,10-phenanthroline characterized by formula 5 to a 2-chloro-1,10-phenanthrolinaminecharacterized by formula 3. The present invention relates further to a method for preparation of a 2-[2-[bis(carboxymethyl)amino]ethyl-[2-[carboxymethyl-[2-[4-[2-(isothiocyanato-1,10-phenanthrolin-2-yl)ethynyl]anilino]-2-oxo-ethyl]amino]ethyl]amino]acetic acidcharacterized by formula 7 and a method for quantifying a biomolecule in a sample. | 10-08-2015 |
20150086513 | METHOD FOR DERIVING MELANOCYTES FROM THE HAIR FOLLICLE OUTER ROOT SHEATH AND PREPARATION FOR GRAFTING - The present invention relates to the field of biology and medicine, and more specifically, to the field of stem-cell biology, involving producing or generating melanocytes from stem-cells and precursors derived from human hair root. Additionally, the present invention relates to the materials and method for producing autografts, homografts or allografts comprising melanocytes in general, as well as the materials and methods for producing autografts, homografts and allografts comprising melanocytes for the treatment of diseases related to depigmentation of the skin and for the treatment of scars. | 03-26-2015 |
20150036145 | Twin-focus photothermal correlation spectroscopy method and device for the characterization of dynamical processes in liquids and biomaterials with the help of absorbing markers - The invention relates to a method and a device for twin-focus photothermal correlation spectroscopy for the characterization of dynamical processes in liquids and biomaterials with the help of absorbing markers. Thereby non-fluorescent absorbing nano objects are heated by an intensity-modulated heating laser which leads to a refractive index gradient lens around the object. This refractive index gradient is detected by a detection laser with a focal volume that, depending on the position of the heated object relative to the focal plane of the detection beam, splits into two-sub-volumes forming a twin-focus comprising two sharply separated parts of a focal volume showing no spatial overlap. | 02-05-2015 |
20140309161 | Modified antibiotic peptides having variable systemic release - The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all. | 10-16-2014 |
20140030714 | Method and means for distinguishing malignant from benign tumor samples, in particular in routine air dried fine needle aspiration biopsy (FNAB) - The invention concerns a method and means for distinguishing malignant from benign tumor samples of the thyroid, by performing a RNA extraction in a standard fine needle aspiration biopsy (FNAB) sample, in particular an air dried FNAB smear. The presence of gene-rearrangements and/or the expression of miRNA is analyzed in the isolated RNA, wherein the presence of a gene-rearrangement and/or the differential expression of miRNA is indicative for a malignant tumor. | 01-30-2014 |
20130316390 | Method for diagnosis and/or prognosis of cancers by analysis of the mechanical properties of tumour cells - A method for diagnosis and/or prognosis of cancers, for diagnosis of the site of origin of tumour cells, for optimizing the treatment of cancer patients and for screening active substances for oncology. In the method, the mechanical properties of tumour cells and reference cells are analyzed under a mechanical load that leads to linear or nonlinear deformation of the respective loaded cell. The expansion of the cells, which results from the input of a directed mechanical stress, is used to determine the risk of tumour metastases and, if appropriate, the presence of uncontrollably proliferating and/or invasive cells, or the tissue of origin of the tumour. The risk of tumour metastases is determined on the basis of the proportion of cells in the sample that have an extension counter to the direction of stressing. The risk of the presence of uncontrollably proliferating cells is determined, in the case of nonlinear deformation of the cell, on the basis of the mean value of the expansion in the direction of stressing of cells in the sample. | 11-28-2013 |
20130251719 | BONE MARROW APLASIA WITH HAEMORRHAGIC DISEASE IN CALVES CAUSED BY NOVEL PATHOGEN - The present invention refers to a novel | 09-26-2013 |
20130211061 | Method and compositions for the identification of agents that have a potential effect against chronic inflammatory diseases - The present invention is based on two important experimental observations: The first observation is that increased extracellular concentrations of ionized calcium are found in erosive arthritis and stimulate monocytic IL-1β release via the CaSR and GPRC6A. Simultaneous stimulation of monocytes with calcium ions and selected TLR ligands results in a 20-fold increased IL1β response compared to lipopolysaccharide (LPS) alone. During the crosstalk between GPCR and TLR signaling, phospholipase C is activated, which triggers calcium dependent potassium channels, resulting in potassium efflux, caspase-1 activation and IL-1β release. The amplification of IL1β secretion at sites of locally increased calcium ion concentrations aggravates rheumatoid arthritis. The second important observation is that both CaSR and GPRC6A, are highly expressed in the synovial membrane of patients with rheumatoid arthritis, but expression of GPRC6A, but not of CaSR, is lower in patients with osteoarthritis (s. FIG. | 08-15-2013 |
20110287472 | MODULAR SYSTEM OF FUNCTIONAL UNITS FOR MIXING, PROCESSING AND/OR SEPARATING SAMPLES FOR USE IN BIOLOGICAL/MEDICAL RESEARCH AND FOR DIAGNOSTICS - Mixing, physical and/or chemical reactions and separation are basic method steps in biological research and diagnosis. In research in particular, there is a need for problem-specific laboratory systems, but these are not commercially available because of small batch sizes and because of the specific problem involved. In the absence of these systems, existing vessels, filters, centrifuges, etc., have to be improvised in order to solve the problem. | 11-24-2011 |
20110166195 | METHOD FOR THE FORMATION OF MEGAMITOCHONDRIA - The present invention relates to an in-vitro method for the formation of megamitochondria in cells, wherein the cells are grown in a suitable fermentation medium acidulated with lactic acid to pH values between 5.3 and 6.7. The invention further concerns H | 07-07-2011 |
20100278786 | USE OF THE OPPOSITE CELL DIFFERENTIATION PROGRAM (OCDP) FOR THE TREATMENT OF DEGENERATED ORGANS IN THE PATHOLOGICAL STATE - The present invention relates to a method for the treatment of organs which are degenerative and/or in the pathological state by means of the use of cells, which are phenotypically stably differentiating or differentiated but not necessarily ultimately predetermined with respect to development, from a donor organ selected according to the principles of the opposite cell differentiation program (OCDP) and also to the use of cells of this type for the treatment or for the production of a drug for treatment of the same. Furthermore, the present invention relates to pharmaceutical agents comprising suitable phenotypically stable cells, cells of a first organ which is different from the second organ with respect to organ type thereby being used, which, in the normal physiological state with respect to a predetermined set of expressed genes and/or phenotypical properties, have opposite properties to the second cells in the normal physiological state. | 11-04-2010 |
20100021447 | Medicament for Treating Problems Relating to Fertility and Pregnancy, and Autoimmune Diseases, and for Inducing an Immunological Tolerance in Transplant Patients, and Method for Producing Said Medicament - A medicament for treating pregnancy disorders or for inducing an immunological tolerance in patients with autoimmune diseases or transplantation processes, contains at least one each of a) a precursor hCG β subunit of the human choriongonadotropine (hCG) selected from hCG β6 according to SEQ ID NO 1 or SEQ ID NO 2 and hCG β7 according to SEQ ID NO 5 or a mature hCG β subunit selected from hCG β6 according to SEQ ID NO 3 or SEQ ID NO 4 and hCG β7 according to SEQ ID NO 6 or glycolised fragments of these sequences; and b) a precursor α subunit of hCG according to SEQ ID NO 9 or the mature α subunit of hCG according to SEQ ID NO 10 or glycolysed fragments of these sequences, wherein the β subunits and the α subunits are preferably used in equimolar quantities. | 01-28-2010 |
20080216182 | Animal Model for the Human Immune System, and Method for Producing the Same - In a method for preparing an animal model for the human immune system in a non-human mammal, human stem cells with hematopoietic potential are transplanted into a non-human mammal. The non-human mammal is conditioned with cell culture supernatant of a culture of human cell lines, cells and/or tissue. The cell culture supernatant is derived from cell lines producing cytokines and other molecular mediators. | 09-04-2008 |