| UNIVERSITAETSKLINIKUM FREIBURG Patent applications |
| Patent application number | Title | Published |
|---|
| 20120074937 | Increasing spoil efficiency - A method for operating a nuclear magnetic resonance imaging device, wherein a continuous sequence of radio-frequency (=RF) pulses are radiated onto a sample, Ψ being the constant phase value for all magnetization vectors, and all magnetization vectors undergo a phase progression F | 03-29-2012 |
| 20110275929 | Device and method for measuring contrast agent - A tomography device ( | 11-10-2011 |
| 20110241678 | Method for homogenizing resolution in magnet resonance tomography measurements using non-linear encoding fields - A method for magnetic resonance (=MR) imaging, wherein non-linear gradient fields are applied for the purpose of spatial encoding to acquire images of an object to be imaged and wherein the magnet resonance signal radiated from the object to be imaged is sampled on grids in time, to thereby obtain sampling points, is characterized in that the object to be imaged is mapped completely in regions of stronger gradient fields by increasing the density of the sampling points in the center of k-space, and additional sampling points are specifically acquired in the outer regions of k-space according to a k-space sampling pattern depending on the desired distribution of the resolution in the measurement, wherein the MR measurement is calculated with the additional sampling points. An MR imaging method is thereby provided by means of which homogenized resolution is achieved in the MR measurements using non-linear gradient fields for spatial encoding. | 10-06-2011 |
| 20110148410 | Method for data acquisition acceleration in magnetic resonance imaging (MRI) using receiver coil arrays and non-linear phase distributions - A method for accelerating data acquisition in MRI with N-dimensional spatial encoding has a first method step in which a transverse magnetization within an imaged object volume is prepared having a non-linear phase distribution. Primary spatial encoding is thereby effected through application of switched magnetic fields. Two or more RF receivers are used to simultaneously record MR signals originating from the imaged object volume, wherein, for each RF receiver, an N-dimensional data matrix is recorded which is undersampled by a factor R | 06-23-2011 |
| 20110110976 | RIFT VALLEY FEVER VIRUS-LIKE PARTICLES AND THEIR USE FOR IMMUNIZATION AND AS TEST SYSTEM - Disclosed is a method for producing virus-like particles (VLP) that comprises the steps of (a) transfecting a mammalian cell line with several independent vectors, including (1) a vector containing at least a substantial part of the M gene from Rift Valley Fever Virus, (2) a vector containing at least a substantial part of the L gene from Rift Valley Fever Virus, (3) a vector containing at least a substantial part of the N gene from Rift Valley Fever Virus and (4) a vector containing a multicloning site flanked by the non-coding 5′- and 3′-ends of the L-, M- or S-segment of Rift Valley Fever Virus, and (b) culturing the transfected mammalian cell line under suitable conditions and obtaining the VLPs from the supernatant of the transfected cultured cell lines. The so-obtained VLPs can be used for vaccination and in methods for testing the antiviral activity of compounds. | 05-12-2011 |
| 20100285026 | PHOSPHORYLATION OF HISTONE H3 AT THREONINE 11 - A NOVEL EPIGENETIC MARK FOR TRANSCRIPTIONAL REGULATION - The present invention relates to a process for controlling at least one androgen receptor- (AR-) regulated mechanism in mammalian cells under histone-phosphorylating conditions, said process comprising allowing at least one inhibitor with specificity for at least one protein kinase C-related kinase (PRK) to act on said at least one PRK1 thereby modulating, preferably down-regulating, the activity of said at least one PRK and optionally blocking said at least one androgen receptor-regulated mechanism in said mammalian cells. | 11-11-2010 |
| 20100259260 | Simultaneous excitation and acquisition of signal from multiple slices in the RARE sequence (multiplex RARE) - A method for RARE magnetic resonance imaging comprising slice selective excitation of two or more slices and of one or more nuclei, followed by refocusing of these slices and application of gradient pulses which cause a diversion of the signal into spin echoes and stimulated echoes, is characterized by application of refocusing slice selective RF pulses, which are placed to fulfill the echo-spacing CPMG condition for each slice and by arrangement of gradient pulses which cause the phase accumulated by spins in each slice between two consecutive refocusing RF pulses corresponding to that slice to be equal, thus fulfilling the CPMG phase accumulation condition. Thereby, the obtainable signal can be increased and stabilized. | 10-14-2010 |
| 20090302838 | MR method for selective excitation - A magnetic resonance method for using radio frequency pulses for spatially selective and frequency selective or multidimensionally spatially selective excitation of an ensemble of nuclear spins with an initial distribution of magnetization in a main magnetic field aligned along a z-axis, wherein a spin magnetization with a given target distribution of magnetization is generated, and for refocusing the spin magnetization, is characterized in that the radio frequency pulse is used as a sequence of sub-pulses of independent duration, courses of gradients and spatial and/or spectral resolution, comprising one or more large angle RF pulses with tip angles greater than or approximately equal to 15°, which generate a gross distribution of magnetization approximating the target distribution of magnetization or a desired modification of the distribution of magnetization with a mean deviation less than or approximately equal to 15°, wherein the actual effect of the LAPs on the distribution of spin magnetization before the radio frequency pulse is used is calculated by integration of the Bloch equations without small angle approximation, and one or more small angle RF pulses=SAPs with tip angles less than or approximately equal to 15° reducing the difference between the target distribution of magnetization and the gross distribution of magnetization caused by the LAPs. | 12-10-2009 |
| 20090233317 | REPRESSOR OF SKELETAL MUSCLE DIFFERENTIATION, NUCLEIC ACIDS CODING THEREFOR AND THE USE THEREOF IN DIAGNOSIS AND THERAPY - Polypeptide sequences which play a part in the regulation of skeletal muscle differentiation, and nucleic acids coding therefor, and the use thereof in diagnosis and therapy are disclosed. Possible uses are also indicated for antibodies which are directed against corresponding epitopes of the GRIM1 polypeptide. | 09-17-2009 |
