| UNIVERSIDADE DE SANTIAGO DE COMPOSTELA Patent applications |
| Patent application number | Title | Published |
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| 20120003322 | PH-SENSITIVE DENDRITIC POLYMERIC MICELLES - The present invention relates to a pH-sensitive PIC (polyion complex) type polymeric micelle formed by electrostatic interaction between a dendritic block copolymer and another polymer of opposite charge. The presence of a dendritic block copolymer confers high stability to the micelles in physiological conditions, while in the acid medium of tumor tissues (pH 6.5) or cell compartments, such as the endosome/lysosome (pH 5.0-5.5), the micelles tend to become destabilized, being able to selectively release drugs or macromolecules encapsulated therein. The micelles are characterized by high stability against ionic strength, dilution and temperature. They can further be lyophilized and conserved in solid state. | 01-05-2012 |
| 20110313032 | COMPETITIVE INHIBITORS OF TYPE II DEHYDROQUINASE ENZYME - The present invention is directed to a compound of formula (I), its diastereoisomers, its enantiomers or its pharmaceutically acceptable salts or solvates, formula (I), to procedures of obtaining the same, to intermediates thereof, and use as competitive inhibitors of the third enzyme of the shikimic acid pathway, the type II dehydroquinase. | 12-22-2011 |
| 20110262500 | CONJUGATES COMPRISING NANOPARTICLES COATED WITH PLATINUM CONTAINING COMPOUNDS - The present invention relates to conjugates of formula (I) having colloidal stability in a medium, wherein NP is a gold, silver or platinum nanoparticle; L is a linker selected from the group consisting of formula (II), formula (III), and a stereoisomer of any of the formulas (II) and (III), which is attached to the nanoparticle NP through sulfur atoms; wherein the meanings of X, n, p, Y and s are further specified in the description; and A is a platinum (II) biradical selected from the group consisting of formula (IV), formula (V) and formula (VI) including any of the stereoisomers of all of them, wherein the biradical is optionally in the form of a salt and is attached to the linker L through the single bonded oxygen atoms of the carboxyl groups. It also relates to a process for the preparation of the conjugates of formula (I) and to pharmaceutical compositions containing them. The conjugates of the invention are used for the treatment of cancer. | 10-27-2011 |
| 20110256059 | NANOPARTICULATE SYSTEMS PREPARED FROM ANIONIC POLYMERS - The present invention relates to a system for administering active ingredients comprising nanoparticles having an average size of less than 1 micrometer in turn comprising: (a) at least one anionic polymer; (b) a cationic cross-linking agent; and optionally (c) a cationic polymer; characterized in that the nanoparticles are cross-linked by means of electrostatic type interactions. Additionally, the invention relates to pharmaceutical, cosmetic, personal hygiene and nutritional compositions comprising said nanoparticle system, as well as to methods for the preparation and uses thereof. | 10-20-2011 |
| 20110213168 | DEUTERATED VITAMIN D COMPOUNDS - The invention relates to deuterated vitamin D compounds and the process for preparing and synthesizing a class of vitamin D compounds which can be isotopically substituted. These compounds can be used as internal standards in methods for the quantification of vitamin D, its metabolites and analogues by mass spectrometry. These compounds are described by means of general formula I. | 09-01-2011 |
| 20110200661 | ACRYLIC HYDROGELS WITH PENDANT CYCLODEXTRINS, PREPARATION METHOD THEREOF AND USE OF SAME AS RELEASE SYSTEMS AND CONTACT LENS COMPONENTS - The invention relates to acrylic hydrogels with pendant cyclodextrins, the preparation and application thereof as release systems and components of contact lenses. The method for obtaining acrylic hydrogels with pendant cyclodextrins is characterized in that the hydrogels are formed by a polymer lattice obtained by polymerization of mono- and bifunctional acrylic or methacrylic monomers and monomers having glycidyl groups in their structure, to which cyclodextrin units are covalently bound once formed; and the use and applications of the compositions in the preparation of contact lenses with the capacity for incorporating drugs, active substances or demulcents useful in the treatment of pathological or physiological conditions, in the production of topical, transdermal or transmucosal release systems for medicinal products or active substances, and in the preparation of cosmetics. | 08-18-2011 |
| 20110195051 | USE OF BACTERIA OF THE GENUS TENACIBACULUM FOR QUORUM QUENCHING - Use of bacterial cells of the genus | 08-11-2011 |
| 20110065138 | Quantitative Method For Detecting Yessotoxins In Fishery Products On Based On The Activation That The Toxin Produces In Cellular Phosphodiesterases And Therapeutic Use Of This Activation - The present invention relates to a quantitative method for detecting yessotoxins in fishery products based on the activation the toxin produces on cellular phosphodiesterases and the therapeutic use of this activation. The cellular target of yessotoxin (YTX) and its analogs is the activation of phosphodiesterases (PDEs). The PDEs-YTX bond produces a measurable signal. The bond can be quantified by means of an affinity biosensor or by fluorescence. The biosensor detects biomolecular interactions and allows determining the presence of YTX due to its interaction with PDEs. The variations in the degradation rate of the fluorescent derivative anthraniloyl-cAMP are determined by means of plate fluorescence. The rate at which the PDEs degrade this molecule increases in the presence of YTX. YTX inhibits immunological activation of mastocytes in rats and induces a cytotoxic effect in human hepatocarcinoma cells, which implies two therapeutic uses of YTXs as an antiallergic and antitumor compound. | 03-17-2011 |
| 20110057447 | FLOATING DEVICE FOR HARNESSING SWELL ENERGY BY LATERAL OVERFLOW - Floating device for harnessing swell energy by lateral overflow, said device being formed by hulls which converge in plan view and have a variable freeboard between which the waves propagate. The convergence produces a gradual increase in the height of the wave as it propagates between the hulls, which, together with the reduction in the freeboard from a particular section of said hulls, gives rise to the lateral overflow of the mass of water of the crest over their rails, which is collected in tanks which are at different heights (in accordance with the reduction in the freeboard) and are connected to the corresponding turbines. The angle of convergence between the hulls can be varied in order to be adapted to the sea state. The harnessing system is supplemented with a connecting closure ramp between the sterns of the hulls in order to collect the water which has previously not managed to overflow the structure. | 03-10-2011 |
| 20090214604 | Method of obtaining hydrogels of cyclodextrins with glycidyl ethers, compositions thus obtained and applications thereof - The invention relates to a method of obtaining hydrogels based on (i) cyclodextrins, (ii) cyclodextrins and cellulose ethers or (iii) cyclodextrins and guar gum or the derivatives of same, using molecules containing two or more glycidyl ether groups in the structure thereof as a cross-linking agent. The invention also relates to the compositions thus obtained, which can include active substances and pharmaceuticals and which form inclusion complexes with cyclodextrins. The invention further relates to the use of same as components of controlled-release devices, such as transdermal pharmaceutical forms, vaginal, otic, ocular, rectal, oral or buccal transmucosal forms and parenteral implants, which are designed to administer active substances or pharmaceuticals to humans, animals or plants, or as components of cosmetic formulations. In addition, the invention relates to the use of said compositions as chelating agents in the extraction of biological or toxic molecules from living organisms or contaminating substances from water. | 08-27-2009 |
| 20090035852 | Stable Atomic Quantum Clusters, Production Method Thereof and Use of Same - Stable atomic quantum clusters, AQCs, characterized by being composed of at least 500 metal atoms, its production process characterized by having a kinetic control and by maintaining a low concentration of reagents in the reaction medium, as well as the uses of these clusters as sensors (fluorescent, magnetic or chemical), electrocatalysts and as cytostatics and/or cytotoxics. | 02-05-2009 |
| 20080261264 | Culture Medium for Detecting of Clostridium Perfringens - The invention relates to a culture medium for the detection of | 10-23-2008 |
| 20080220030 | Nanoparticles Comprising Chitosan and Cyclodextrin - This invention relates to a system comprising nanoparticles designed for the release of biologically active molecules, where the nanoparticles comprise a) at least 40% by weight of chitosan or a derivative thereof and b) less than 60% by weight of a cyclodextrin or a derivative thereof, where both components a) and b) are mixed, without any covalent bond between them. This system allows for the efficient association of biologically active molecules, as well as their subsequent release in a suitable biological environment. | 09-11-2008 |
