| UMC UTRECHT HOLDING B.V. Patent applications |
| Patent application number | Title | Published |
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| 20110313294 | APPARATUS AND METHOD FOR DETERMINING THE POSITION OF A VEIN OR ARTERY - Apparatus and method for determining the position of a vein or artery in a member of a living being. With an IR light source, more particular an IR led light source, the related member such as an extremity and more particular a hand, is trans-illuminated. The IR light emerging from the member is scanned with a camera and the image is produced on a display adjacent to the camera. Camera and display are preferably mounted on a manoeuvrable arm which can be placed in any desired position relative to the member and observer. Displacement of the camera/display unit can be effected through the presence of a grip to be operated by the hand of the observer. If the quite position is found relative to the member the hand of the observer can be used to execute the related treatment to the vein or artery. | 12-22-2011 |
| 20110118194 | Therapeutic Use of LPI, a Staphylococcal Lectin Pathway Inhibitor in Inflammatory Diseases - The invention relates to nucleic acid molecules encoding (poly)peptides having LPI (Lectin Pathway Inhibitor) activity, to recombinant vectors harboring such molecules, and the host cells carrying the vectors. The invention further relates to methods for preparing recombinant (poly)peptides having LPI activity and to the use of such recombinant (poly)peptides having LPI activity for diagnosis, prophylaxis and treatment, such as the treatment of inflammation reactions. In addition the invention provides therapeutic and diagnostic compositions comprising as the active ingredient the (poly)peptide having LPI activity. | 05-19-2011 |
| 20110087261 | Device and Method for Transseptal Puncturing - Device for a medical procedure within the vasculature of a patient, comprising puncturing means provided at a distal end of the device for puncturing tissue in a supported state, and an elongate member having a proximal end, a distal end provided with a puncturing means and a flexible length therebetween, wherein the elongate member is arranged to be advanced through the vasculature in an unsupported state of the puncturing means without damaging the walls of the vasculature. | 04-14-2011 |
| 20100191239 | System for Correcting Bones - System for correcting bones, comprising: —at least a first pin which can be connected to the bone at a first location; —at least a second pin which can be connected to the bone at a second location at a distance from the first location; —a fixation member which is coupled rigidly to the first and second pins for the purpose of fixing the mutual distance between the pins during a hardening phase, and which is coupled flexibly to the first and the second pins during a correction phase; and —at least a first annular fixation member which is removably connected to the first pin and at least a second annular fixation member which is removably connected to the second pin for the purpose of adjusting the bone during the correction phase. | 07-29-2010 |
| 20100047250 | ACTIVATION EPITOPE OF FCY RII (CD32), BINDING MOLECULES THAT SPECIFICALLY BIND THE EPITOPE AND MEANS AND METHODS FOR THE DETECTION OF THE EPITOPE, AND USES OF SAID EPITOPE OR SAID BINDING MOLECULES - The present invention provides means and method for detecting an activation epitope on FcyRII (CD32) on Fcγ (CD32) expressing cells. The presence of epitope on FcγRII (CD32) correlates with priming of the cell containing FcγRII (CD32) expressing said epitope. The invention further provides binding molecules specific for said activation epitope on FcγRII (CD32), and uses thereof in the detection of activated cells. Further uses are the treatment of individuals suffering from inflammation or at risk of suffering thereof. Also provided, among others, are uses for detecting and/or following an inflammation in an individual. | 02-25-2010 |
| 20090258008 | Uses of the FcRn Receptor - The invention relates to the field of biochemistry and molecular biology. More specifically the invention relates to the production of (monoclonal) antibodies and even more specifically to the production of therapeutic and diagnostic antibodies. The invention provides a method for producing an antibody or a functional part, derivative and/or analogue thereof in a cell, comprising providing a cell that is capable of producing said antibody with FcRn receptor protein and culturing said cell to allow for production of said antibody. | 10-15-2009 |
| 20090246175 | THERAPEUTIC USE OF SCIN, A STAPHYLOCOCCAL COMPLEMENT INHIBITOR IN INFLAMMATORY DISEASES - The present invention relates to the use of the staphylococcal complement inhibitor (SCIN) or a homologue thereof, or a derivative or a fragment of SCIN or the SCIN homologue for the preparation of a medicament for intervening with C3 and C5 convertases. The medicament is in particular intended for inhibiting activation of the classical and/or the alternative pathway of complement. More in particular, the medicament is for treating indications that involve complement activation via the classical and/or alternative pathway. | 10-01-2009 |
| 20090098563 | Diagnosis of (a risk of) disease and monitoring of therapy - Provided are methods for typing a sample of an individual suffering from, or at risk of suffering from, a disease and a method for monitoring treatment of an individual suffering from a disease comprising determining whether a sample from the individual comprises an expression product of AC133 in an amount that is indicative for the disease or for the treatment thereof. That amount may be quantified and compared with a reference value. In one aspect, the amount is compared with an amount of the expression product present in a sample that was obtained from the individual before treatment. Use of a nucleic acid molecule comprising at least part of a sequence of AC133, or an analogue thereof, for monitoring a treatment of an individual suffering from a disease is also provided, as well as a diagnostic kit comprising such nucleic acid molecule. | 04-16-2009 |
| 20080293076 | Method to improve barrier function of cell-cell junctions - Described are methods of increasing the barrier function of a cell-cell junction, comprising activating a PDZ-GEF2 protein, wherein the PDZ-GEF2 protein comprises an amino acid sequence encoded by a gene corresponding to the RapGEF6 gene. Further described are methods for selecting an activator of PDZ-GEF2, comprising contacting a plurality of candidate compounds to at least two cells of a first cell type and at least two cells of a second cell type, both cell types capable of forming cell-cell junctions, measuring the maturation of cell-cell junctions before and after contacting the two cell types with the plurality of candidate compounds, and selecting a compound from the plurality of candidate compounds that is more capable of increasing the integrity of a cell-cell junction between at least two cells of the first cell type, as compared to its capability of increasing the integrity of a cell-cell junction between cells of the second type, wherein in the second cell type, the amount and/or activity of PDZ-GEF2 is decreased, compared to the first cell type. | 11-27-2008 |
