| TUFTS UNIVERSITY Patent applications |
| Patent application number | Title | Published |
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| 20130058962 | Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein - Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant heteromultimeric neutralizing binding protein including two or multiple binding regions, such that the binding regions are not identical, and each binding region specifically binds a non-overlapping portion of the disease agent, thereby treating the subject for exposure to the disease agent. In a related embodiment, the heteromultimeric neutralizing binding protein includes two or multiple binding regions that neutralize a plurality of disease agents. In certain embodiments, the disease agent includes a bacterium, a bacterial protein, a virus, a viral protein, a cancer cell, and a protein or molecule produced therefrom. In certain embodiments, the disease agent is a plurality of different disease agents. | 03-07-2013 |
| 20130018273 | SYSTEMS AND METHODS FOR ANALYSIS OF FETAL HEART RATE DATA - The present invention relates to systems and methods for analyzing fetal heart rate data. In particular, the present invention provides electronic rulers for use in analyzing fetal heart rate data. | 01-17-2013 |
| 20120325965 | INFLATABLE AND RIGIDIZABLE SUPPORT ELEMENT - The present invention provides novel inflatable and rigidizable support elements, and methods of manufacture and use thereof. In particular, the present invention provides inflatable and rigidizable support elements which find use in rapidly deploying and supporting the wing of an aerial vehicle. | 12-27-2012 |
| 20120295346 | METHODS AND COMPOSITIONS FOR MODULATING MEMBRANE POTENTIAL TO INFLUENCE CELL BEHAVIOR - The present invention provides methods for controlling proliferation, differentiation, and/or migration of cells by modulating membrane potential through an endogenously expressed channel protein. The present invention also provides methods for identifying candidate instructor cells, as well as therapeutic agents that are useful for modulating (e.g., promote or inhibit) proliferation and differentiation, as well as promoting regeneration of a desired tissue type. | 11-22-2012 |
| 20120276132 | Atoxic recombinant holotoxins of Clostridium difficile as immunogens | 11-01-2012 |
| 20120275979 | SULFUR-TOLERANT WATER-GAS SHIFT CATALYSTS - A method for oxidizing carbon monoxide by a water-gas shift (WGS) reaction and a method for reducing carbon dioxide by a reverse water-gas shift (RWGS) reaction, both using a catalyst of the formula xMZLn | 11-01-2012 |
| 20120259211 | SYSTEMS, DEVICES, AND METHODS EMPLOYING FIBER OPTIC SHAPE TRACKING - The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of the shape and position of objects whose shape dynamically changes with time. Applications include tracking and monitoring of endoscopes for diagnostic and surgical procedures. | 10-11-2012 |
| 20120258548 | REDOX SENSOR - Provided herein are devices, methods, and uses for measuring redox potential. For example, provided herein are fiber optic redox sensors and methods of use thereof. | 10-11-2012 |
| 20120245221 | ANTI-APOPTOTIC AGENTS AND USES THEREOF - The invention generally relates to the use of parasite-derived neurotrophic factor (PDNF), or a fragment of PDNF, to reduce cell apoptosis. The PDNF or PDNF fragment is provided in the cytoplasm of a cell so that it can bind to Akt kinase and induce Akt kinase activation. | 09-27-2012 |
| 20120232000 | METHODS AND COMPOSITIONS FOR PROMOTING REGENERATION BY INCREASING INTRACELLULAR SODIUM CONCENTRATION - The invention provides methods and compositions for increasing the intracellular sodium concentration in a cell. | 09-13-2012 |
| 20120201780 | T. CRUZI-DERIVED NEUROTROPHIC AGENTS AND METHODS OF USE THEREFOR - The invention relates to | 08-09-2012 |
| 20120136033 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof - Disclosed are a new class of non-lipid small molecule inhibitors which interfere with the interaction between PIP3 and pleckstrin homology domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided. | 05-31-2012 |
| 20120064518 | Methods, tip assemblies and kits for introducing material into cells - Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce fluid pressure as a fluid passes through the constriction portion from the channel portion, whereby the tip assemblies form pores in the membranes of cells and introduce material into the cells. The material includes for example one selected from the group of: an inorganic compound, a drug, a genetic material, a protein, a carbohydrate, a synthetic polymer, and a pharmaceutical composition. | 03-15-2012 |
| 20120058117 | NEUROPILIN-1 INHIBITORS - The present invention relates to molecules interfering with the function of neuropilin-1 in the context of angiogenesis and the treatment of cancer. Molecules, polypeptides, antibodies, compositions and methods are provided that are useful for reducing, inhibiting or treating angiogenesis, the invasion of blood vessels into tumors, and/or the invasion or the metastatic potential of specific tumor cells. Additionally, a method is provided that allows identifying molecules, which interfere with the functionality of neuropilin-1. Furthermore, a method is provided that allows determining whether a naturally occurring tumor cell depends on functional neuropilin-1 for its invasiveness and/or metastatic potential. | 03-08-2012 |
| 20120035403 | CONVERTING BIOMASS TO GASEOUS FUEL HYDROCARBONS - A method includes providing a solution containing a C | 02-09-2012 |
| 20120016033 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof - Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided. | 01-19-2012 |
| 20110319398 | INHIBITION OF YOPS TRANSLOCATION - The disclosure relates to compounds and methods of inhibiting type three secretion system effector molecules, to methods of detecting compounds that inhibit Yops translocation, and to methods of treating or preventing infections by administering compounds described herein to a subject in need thereof. | 12-29-2011 |
| 20110280847 | METHODS AND COMPOSITIONS FOR INHIBITING CLOSTRIDIUM DIFFICILE SPORE GERMINATION AND OUTGROWTH - Certain bile acids, including novel bile acids, and derivatives thereof can be used to inhibit the germination of | 11-17-2011 |
| 20110275538 | MEASUREMENT OF BIOLOGICAL TARGETS - An integrated imaging system, e.g., a microsystem, for detecting activity of a biological target, for example, in response to a stimulus, includes an array of pixels arranged on a substrate, each pixel including a photodetector disposed to be in optical communication with a biological target on a surface of the substrate; and at least first and second electrodes arranged in electrical communication with the biological target. | 11-10-2011 |
| 20110272348 | IRON-MEDIATED REMEDIATION WITHIN NONAQUOUS PHASE LIQUID - The present invention relates to remediation of hazardous waste sites. In particular, the present invention relates to compositions and methods for remediation of environmental contaminants in non-aqueous phase liquids (NAPLs). | 11-10-2011 |
| 20110262971 | Genetically Modified E. coli Strains for Producing Erythromycin - Genetically modified | 10-27-2011 |
| 20110172519 | SYSTEMS, DEVICES AND METHODS EMPLOYING FIBER OPTIC SHAPE TRACKING - The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of the shape and position of objects whose shape dynamically changes with time. Applications include tracking and monitoring of endoscopes for diagnostic and surgical procedures. | 07-14-2011 |
| 20110152352 | SMAD PROTEINS CONTROL DROSHA-MEDIATED MIRNA MATURATION - The invention, in some aspects, relates to compositions and methods useful for modulating expression of miRNAs that are regulated by the TGF-β/BMP signaling pathway. In some aspects, the invention relates, to oligonucleotides comprising a CAGRN-motif that modulate expression of miRNAs that are regulated by TGF-β/BMP signaling pathway. The invention, in some aspects, relates to composition and methods useful for inhibiting microRNA processing. In some aspects, the invention relates to composition and methods for treating TGF-Beta/BMP mediated disorders. | 06-23-2011 |
| 20110150775 | GENOMIC APPROACHES TO FETAL TREATMENT AND DIAGNOSIS - The present invention provides systems for developing and/or testing therapies for prenatal diseases and conditions including Down Syndrome. The present invention also provides diagnostic methods for Down Syndrome involving, in some embodiments, gene expression analyses of fetal RNA and/or detection of expression of particular genes involved in Down Syndrome. Also provided are microarrays and kits useful in prenatal diagnostic applications. | 06-23-2011 |
| 20110138902 | MEMS MICROPHONE ARRAY ON A CHIP - The present invention relates to microelectromechanical systems (MEMS). In particular, the present invention relates to MEMS arrays for use in acoustics and other applications. | 06-16-2011 |
| 20110132871 | SHEAR SENSORS AND USES THEREOF - The present invention relates to shear sensors. In particular, the present invention relates to deformable sensors for measurement of shear forces during chemical mechanical polishing. | 06-09-2011 |
| 20110118125 | NEONATAL SALIVARY GENOMICS - The present invention provides systems for assessing neonatal development and/or conditions by analyzing neonatal saliva RNA. Methods of identifying genes involved in neonatal development and/or conditions affecting neonates, are provided. Methods of determining a diagnosis of a neonate comprising detection of one or more differentially expressed genes are also provided. | 05-19-2011 |
| 20110110922 | Wound Healing Peptides and Methods of Use Thereof - Methods and compositions for the treatment of wounds in a mammalian subject are provided. Particularly, novel polypeptides and encoding nucleic acids that stimulate keratinocyte and endothelial cell motility and/or proliferation are provided. | 05-12-2011 |
| 20110104653 | INTERACTIVE DIGITAL WORKBOOK SYSTEM AND METHOD - A digital workbook program, method, and system include a program interface module configured to communicate with a set of applications and a workbook module configured to generate a digital workbook from a master digital workbook. The digital workbook includes content and mechanisms that enable inputs to and receipt of outputs from the set of applications. Also included are a user interface module configured to generate user interface screens within which the digital workbook is presented and a storage module configured to store the digital workbook with user-entered inputs and outputs from the set of applications. The applications can communicate with a set of devices. Also, the digital workbook program, method, and system can be configured to enable authoring of digital workbooks and presentation in a visual library, as well as analysis of user specific digital workbooks. | 05-05-2011 |
| 20110104200 | Methods, compositions and kits for vegetative cell-based vaccines and spore-based vaccines - Methods for immunizing a subject to an antigen of an infectious agent, a tumor, or an allergen are provided, using vegetative cytoplasmic expression of the antigen or spore surface display of the antigen, and contacting the subject with a composition including a spore or a vegetative cell or both with or without an adjuvant. Also included are thermally-stable vaccine compositions using the method described above and kits including the compositions. | 05-05-2011 |
| 20110015136 | humanized model of membrane attack complex (MAC) formation on murine retina and compositions, kits and methods for treatment of macular degeneration - Methods and compositions for treating a subject having age-related macular degeneration (AMD), methods of assaying human macular degeneration (MD), and methods and kits for assaying potential therapeutic agents for treatment of human MD are provided herein. | 01-20-2011 |
| 20110008906 | Genetic Association of Polymorphisms in Perilipin (PLIN) Gene With Resistance to Weight Loss - Diagnostics and therapeutics for resistance to weight-loss, which are based upon the identification of a subject's PLIN polymorphisms, haplotype and genotype pattern, are described in this invention. | 01-13-2011 |
| 20100292543 | Analysis of Endogenous Fluorescence Images to Extract Morphological/Organization Information About Living Samples - Methods and computer program products for analyzing tissue are provided. The tissue is exposed to light at the appropriate wavelengths for inducing fluorescence. Images of the fluorescing tissue are taken at two or more depths within the tissue. The PSD function is determined for each image at a different depth within the tissue. A characteristic of each PSD function determined is compared, and it is determined whether or not the tissue exhibits a pre-cancerous characteristic. | 11-18-2010 |
| 20100286250 | FLUORINATED LIPIDS AND METHODS OF USE - The invention provides methods and compounds for delivering agents to cells. The compounds can include a fluorinated lipid, a linker, and an agent for delivery to a cell. | 11-11-2010 |
| 20100277234 | Low Power BPSK Demodulator - A low power BPSK demodulator having a simple architecture, compact design and reliable is provided. The BPSK demodulator includes a first branch ( | 11-04-2010 |
| 20100272651 | METHOD FOR ASSESSING POTENTIAL FOR TUMOR DEVELOPMENT AND METASTASIS - The present invention generally provides methods for assessing the potential of tumor formation and/or metastasis using a combination (e.g., a ratio) of the number of circulating tumor cells and the number of circulating cells exhibiting autofluorescence within a selected wavelength region (e.g., red autofluorescence). In one aspect, it is directed to a method for providing likelihood of occurrence of a primary and/or a metastatic cancerous tumor in an animal, which comprises inoculating the animal with a plurality of cancer cells, determining a ratio of a number of cancer cells relative to a number of circulating indicator cells (e.g., immature leukocytes) that exhibit autofluorescence in the inoculated animal's blood and correlating the ratio to a likelihood that the animal will develop at least one primary and/or metastatic cancerous tumor, e.g., by way of assigning a probability for tumor development and/or metastasis based on the measured ratio. The method can also be utilized in human studies using, e.g., contrast agents to identify the circulating tumor cells. | 10-28-2010 |
| 20100247566 | CHOLERA VACCINES - The methods and compositions of the present invention are directed to a vaccine against | 09-30-2010 |
| 20100233421 | Doubly-Curved Mesh - A doubly-curved mesh ( | 09-16-2010 |
| 20100211357 | METHOD FOR MUTLI-STAGE SPATIAL SAMPLING WITH MULTIPLE CRITERIA - The present invention provides a method for implementing a multi-stage spatial sampling strategy to select optimal sampling locations and determine an optimal sampling density for a quantification of mass discharge uncertainty in a field. The present invention also provides systems and methods for estimating probability of a mass discharge in a control plane. | 08-19-2010 |
| 20100209447 | Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits - A peptide-POD with ability to penetrate and deliver fluorophores, siRNA, DNA and quantum dots to cells in culture and retinal and ocular tissues in vivo is provided herein. POD couples to adenovirus vectors, enhancing tropism for certain cells, potentially providing a safer and more efficacious method to deliver molecules to ocular and other tissues in vivo. POD constructs are therapeutic delivery vehicles for treating cells and tissues, including ocular cells and tissues suffering from retinal degeneration. | 08-19-2010 |
| 20100208996 | DEVICES AND METHODS FOR RESTORING LOW-RESOLUTION TEXT IMAGES - A system that extracts text from an image includes a capture device that captures the image having a low resolution. An image segmentation subsystem partitions the image into image segments. An image restoration subsystem generates a resolution-expanded image from the image segments and negates degradation effects of the low-resolution image by transforming the image segments from a first domain to a second domain and deconvolving the transformed image segments in the second domain to determine parameters of the low-resolution image. A text recognition subsystem transforms the restored image data into computer readable text data based on the determined parameters. | 08-19-2010 |
| 20100184838 | Compositions and methods for retinal transduction and photoreceptor specific transgene expression - Adenovirus (Ad) vectors are here provided for treatment of ocular tissues as are suitable methods to transduce photoreceptor (PR) cells, the tissue associated with degeneration. Expression from CMV or chicken beta actin (CBA) promoters in neural retina were compared, and CBA was found to be 173-fold more potent than CMV. Further, the RGD domain in Ad penton was found to play a key role in RPE tropism. Deletion of the RGD domain coupled with the CBA promoter permitted transgene expression in neural retina approximately 667-fold more efficiently than with prior Ad5 vectors. Use of Ad vectors in combination with a 4.7 kb rhodopsin promoter enabled transgene expression exclusively in photoreceptor cells in vivo. | 07-22-2010 |
| 20100184081 | GENETIC MARKERS FOR OBESITY - The present invention is directed to new genetic variants or polymorphisms at the perilipin locus (PLIN) including PLIN1: 6209T (allele 1)>C (allele 2); PLIN3 10171 (allele 1) A >T (allele 2); PLIN4: 11482G (allele 1)>A (allele 2); PLIN5: 13041A (allele 1)>G (allele 2) and PLIN6: 14995A (allele 1)>T (allele 2), and their use in diagnostic and prognostic applications for obesity and obesity-related diseases, such as metabolic syndrome and cardiovascular disease. | 07-22-2010 |
| 20100169038 | METHODS FOR CALCULATING PARTICLE SIZE DISTRIBUTION - The present invention provides processes employing algorithms and methods for calculating particle size distribution. In particular, the present invention provides processes employing algorithms and methods for calculating particle size distribution of different particle shapes from chord length distributions. | 07-01-2010 |
| 20100032547 | METHOD AND SYSTEM OF ARRAY IMAGING - The present invention relates to a method and system of array imaging that extends or maximizes the longevity of the sensor array by minimizing the effects of photobleaching. The imaging system has a light source, a variable exposure aperture, and a variable filter system. The system extends the longevity of sensors by (1) using the variable exposure aperture to selectively expose sections of the sensor array containing representative numbers of each type of sensor, and/or (2) using the variable filter system to control the intensity of the excitation light, providing only the intensity required to induce the appropriate excitation and increasing that intensity over time as necessary to counteract the effects of photobleaching. | 02-11-2010 |
| 20100004163 | Composition and Uses of a Galectin for Treatment of Dry Eye Syndrome - Methods for the therapeutic treatment of dry eye in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-1 protein, a galectin-3, a galectin-7 protein and/or a galectin-8 protein are provided. Pharmaceutical and ophthalmic compositions and kits, comprising a pharmaceutically an active agent which is a galectin-1 protein, a galectin-3 protein, galectin-7 protein and/or a galectin-8 protein, and a suitable carrier or a diluent, are provided. | 01-07-2010 |
| 20100003158 | VIBRATORY POWDER CONSOLIDATION - A vibratory powder consolidation process is provided in which a powder material is subjected to vibratory energy while under static compressive loading. The process provides rapid, full-density powder consolidation with minimum or no structural degradation. | 01-07-2010 |
| 20090232901 | POLYMERIC MICROSPHERES - The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness. | 09-17-2009 |
| 20090117593 | T. Cruzi-derived neurotrophic agents and methods of use therefor - The invention relates to | 05-07-2009 |
| 20090027398 | METHOD FOR RECOGNIZING A SHAPE FROM A PATH OF A DIGITIZING DEVICE - Described is a method for recognizing a shape from a path of a digitizing device. A set of points along a path of the digitizing device is acquired and a parametric representation is fit to the path. The parametric representation is compared to a set of known shapes to determine that the path of the digitizing device represents a particular shape. Fitting the parametric representation to the path includes generating a vector distance field representation of a set of objects corresponding to the set of digitized points, initializing a parametric representation to fit the set of objects, determining a fitting error from the vector distance field representation and adjusting the parametric representation to reduce the fitting error. The fitting error indicates an accuracy of the fit of the parametric representation to the set of objects. | 01-29-2009 |
| 20090027397 | METHOD FOR FITTING A PARAMETRIC REPRESENTATION TO A SET OF OBJECTS GENERATED BY A DIGITAL SKETCHING DEVICE - Described is a method for sketching with a digitizing device. A set of digitized points along a path of the digitizing device are acquired and a parametric representation is fit to the path. Fitting includes generating a vector distance field representation of a set of objects corresponding to the set of digitized points and initializing a parametric representation for the set of objects. A fitting error indicating an accuracy of the fit of the parametric representation to the set of objects is determined from the vector distance field representation. The parametric representation is adjusted and the fitting error is again determined in an iterative manner until an acceptable fitting error is achieved. The method has numerous technical advantages such as robustness, speed, simplicity relative to standard approaches, and the ability to manage constraints such as maintaining corners and enforcing continuity. | 01-29-2009 |
| 20090027396 | METHOD FOR FITTING A PARAMETRIC REPRESENTATION TO A SET OF OBJECTS - Described is a method for fitting a parametric representation to digital data. A vector distance field is generated to represent a set of objects and a parametric representation for the set of objects is initialized. A fitting error is determined from the vector distance field representation. The fitting error indicates the accuracy of the fit of the parametric representation to the set of objects. The parametric representation is adjusted and the fitting error is again determined in an iterative manner until an acceptable fitting error is achieved. The method has numerous technical advantages such as robustness, speed, simplicity relative to standard approaches, and the ability to manage constraints such as maintaining corners and enforcing continuity. | 01-29-2009 |
| 20080306619 | Systems And Methods For Synchronizing Music - The present invention relates to music systems. In particular, the present invention relates to music systems capable of altering the rate of play (e.g., beats per time interval) of a musical piece such that it matches a user's rate of movement per time interval. | 12-11-2008 |
