| 20100101997 | METHOD OF ISOLATING TARGET SUBSTANCE USING MEMBRANE AND APPARATUS THEREFOR - A separation apparatus using a membrane for diafiltration, which provides precise fractionation of a target substance by monitoring and regulating permeability of the target substance based on measurement values and analytical values indicating separation status, such as physical values and concentration of a permeate liquid, a circulating liquid and an internal circulating liquid in a membrane device. A diafiltration process including adding a cleaning liquid to an treating liquid which contains multiple target substances and extracting a target substance into the permeate liquid supplied from a membrane separation apparatus to fractionate the target substance from other target substances remaining in a residual liquid. In the present invention, permeability of the target substance is controlled by regulating or controlling at least one operating parameter, such as a flow rate of the permeate liquid, operating pressure and temperature of the membrane separation apparatus, and concentration and amount of a circulating liquid, to a predetermined range based on a separation status index and/or a progress index of a separating operation. | 04-29-2010 |
