| Trustees of the University of Pennsylvania Patent applications |
| Patent application number | Title | Published |
|---|
| 20120064033 | MODULATION OF REGULATORY T CELLS BY HUMAN IL-18 - The present invention relates to compositions and methods for modulating the presence and/or activity of regulatory T cells in a subject. | 03-15-2012 |
| 20120038987 | OPTICAL DEVICE USING DOUBLE-GROOVE GRATING - Optical devices using double-groove diffraction gratings having periodic sets of TiO | 02-16-2012 |
| 20110245467 | Rapid, Sensitive and Quantitative Methods for Tissue and Cell-Based Proteomics Via Consecutive Addition of Quantifiable Extenders - Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter. | 10-06-2011 |
| 20110189125 | Modulators of HSP70/DnaK Function and Methods of Use Thereof - Compositions and methods for modulating HSP70 function, particularly for the targeted killing of cancer cells, are disclosed. | 08-04-2011 |
| 20110181957 | OPTICAL LIGHT SWITCH USING DOUBLE-SIDED DIFFRACTION STRUCTURE - A light switch (or valve) made up of two mutually inverted, substantially identical diffraction gratings with a liquid medium therebetween, arranged to allow the grating substrates to be shifted laterally relative to one another so as to align and mis-align the grating elements. When aligned, incident-polarized light passes through the switch and when misaligned, light does not pass through the switch but is reflected. | 07-28-2011 |
| 20110142837 | Method Of Treating Acute Respiratory Distress Syndrome - Methods for treating and/or alleviating acute respiratory distress syndrome in an individual diagnosed with or at risk of developing acute respiratory distress syndrome are disclosed. The methods comprise administering a therapeutically effective amount of a complement inhibitor or a TNF-alpha inhibitor to the individual, wherein the complement inhibitor or the TNF-alpha inhibitor reduces or prevents tissue factor production in alveolar neutrophils, thereby treating the ARDS, or delaying or preventing onset of ARDS. | 06-16-2011 |
| 20100331964 | Ex Vivo Remodeling of Excised Blood Vessels for Vascular Grafts - The present invention provides an ex vivo vascular remodeling methods and system by which an excised, small diameter blood vessel can be harvested and expanded to provide viable vascular grafts, as demonstrated at the physical and molecular levels, and as optimized in vivo. The tissue-engineered vessels generated by the present invention closely resemble native vessels in terms of structure, histologically, including endothelial coverage and intricate structural components such as the internal elastic lamina, viability (as measured with MTT assay and TUNEL analysis), and function (vasoactivity, mechanical and biomechanical properties). Thus, the resulting vascular grafts behave in a manner similar to native arteries in terms of mechanical integrity, and provide clinically relevant patency rates when implanted in vivo. Moreover, the ex vivo methods and system permit the precise control of the mechanical environment involving the excised vessel, while at the same time permitting carefully monitoring of the resulting growth/remodeling, thereby opening new avenues of research regarding the mechanical stimuli responsible for specific aspects of remodeling in vivo. | 12-30-2010 |
| 20100189649 | MONOCLONAL ANTIBODIES TO ACTIVATED ERBB FAMILY MEMBERS AND METHODS OF USE - Antibodies which bind to activated members of the erbB, TNF, and IgSF family of receptors and pharmaceutical compositions comprising the same are disclosed. Peptides and mimetics of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are also described. Methods of using such antibodies, peptides, and mimetics in tumor therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 07-29-2010 |
| 20100075899 | TARGETED PHOTODYNAMIC THERAPY AGENT - The present invention relates to the field of conjugates comprising a substrate, a photosensitizer, and a targeting ligand, and methods for their use. More particularly, the invention further relates to methods for treating cancer in a subject using the conjugates of the present invention. | 03-25-2010 |
| 20100040617 | Method of Using CD100 (or Sema4D) to Mediate Platelet Activation and Inflammatory Responses - This invention relates to methods of treating platelet disorders and/or endothelial cell disorders by modulating sema4D/CD100 activity. Specifically, this invention involves the use of compounds to increase or decrease the level of soluble sema4D/CD100. | 02-18-2010 |
| 20090305408 | Method for the rapid expansion of antigen specific t-cell - The present invention encompasses a method for expanding an antigen specific T cell from a population of cells. The method of the present invention comprises contacting a population of cells with an MHC restricted antigenic peptide, a cytokine and a co-stimulatory signal. The invention also encompasses compositions and kits comprising an antigen specific T cell. | 12-10-2009 |
| 20090221527 | TUMOR NECROSIS FACTOR INHIBITORS - The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-α mediated conditions. | 09-03-2009 |
| 20090080297 | FREQUENCY-MODULATED CODING AND DATA RECORDING AND STORAGE USING PLASMONIC NANOSTRUCTURES - A frequency-modulated coding and data recording and storage device that uses plasmonic-dielectric nanostructures of concentric two-layer core-shell design to store data includes a flat transparent substrate having a top surface divided into cells with side dimension d on the order of tens of nanometers and a core-shell plasmonic-dielectric nanostructure disposed in each cell. Each plasmonic nanostructure of concentric core-shell has a predetermined ratio of radii and a predetermined aspect ratio such that when an infrared or visible wavelength signal is applied to each said core-shell plasmonic-dielectric nanostructure a peak scattering amplitude of the applied signal is at different plasmonic resonance frequencies for core-shell plasmonic-dielectric nanostructures with different ratio of radii and different aspect ratios. The sampled values of a signal to be recorded are assigned to each cell and the ratio of radii and/or aspect ratios of the core-shell plasmonic-dielectric nanostructures in the assigned cells are selected to provide a corresponding plasmonic resonant frequency. | 03-26-2009 |
| 20080279698 | CONTROLLED MAGNETOHYDRODYNAMIC FLUIDIC NETWORKS AND STIRRERS - The present invention relates to controlled, magnetohydrodynamically-driven, fluidic networks containing a plurality of individually controlled branches. The branches consist of conduits equipped with pairs of electrodes that are controlled by electrode controllers. In operation, the network is placed within a magnetic field and potentials or currents are applied across electrode pairs within the various branches of the network in specifically determined magnitudes and polarities for specifically determined time intervals in accordance with an activation sequence that may be determined by an algorithm. Placed within a temperature gradient, at least a part of the network can act as a thermal cycler for use in biological interactions that employ temperature variations. The invention also relates to magnetohydrodynamic stirrers comprising a conduit or cavity having at least two electrodes disposed in such an orientation that, upon the application of a potential or current across the electrode pair within a magnetic field, secondary flows such as chaotic advection is generated. | 11-13-2008 |
