| Trustees of Dartmouth College Patent applications |
| Patent application number | Title | Published |
|---|
| 20120122877 | Compositions for Treating Bacterial Infections - The present invention is antibiotic compositions having the ability to disrupt a MazEF complex in | 05-17-2012 |
| 20120115157 | Methods for Screening for Antibiotic Compounds - The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell. | 05-10-2012 |
| 20120094950 | Nutraceutical Composition and Methods for Preventing or Treating Multiple Sclerosis - The present invention embraces nutraceutical compositions containing isolated | 04-19-2012 |
| 20120071396 | Compositions and Methods for Inhibiting the Interaction Between CFTR and CAL - The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface. | 03-22-2012 |
| 20120045477 | Method for Treating Cancer with Toxoplasma Gondii Vaccine - The present invention provides attenuated | 02-23-2012 |
| 20120041315 | Fluorescence Lifetime Spectrometer (FLS) and Methods of Detecting Diseased Tissue - This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition times of less that one second. This invention is useful for studying human tissues and cells in vivo. | 02-16-2012 |
| 20120029063 | CHIMERIC NK RECEPTOR AND METHODS FOR TREATING CANCER - The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided. | 02-02-2012 |
| 20120022097 | Compositions and Methods for Treating Cancer - The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the antitumor compound. | 01-26-2012 |
| 20120021415 | Methods for Determining Response to Neoadjuvant Therapy and Survival Using MicroRNA-10b - The present invention provides methods for determining response to neoadjuvant therapy and metastasis-free survival in pancreatic ductal adenocarcinoma based upon the level of microRNA expression and optionally the presence of a protein cancer cell marker in biological samples such as formalin-fixed paraffin-embedded specimens using in situ hybridization and optionally an immunohistochemical assay. | 01-26-2012 |
| 20110237656 | Method of Selectively Inhibiting the Activity of ACAT1 in the Treatment of Alzheimer's Disease - The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2. | 09-29-2011 |
| 20110190156 | MOLECULAR SIGNATURES FOR DIAGNOSING SCLERODERMA - The present invention features methods for classifying, determining severity, and predicting clinical endpoints of scleroderma based upon the expression of selected biomarker genes. | 08-04-2011 |
| 20110158911 | Methods for Screening for Antibiotic Compounds - The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell. | 06-30-2011 |
| 20110150876 | Prognosis and Treatment of Breast Cancer - The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival and select treatment modalities for breast cancer. The present invention is also a method for inducing apoptosis in breast cancer cells by inhibiting the expression or activity of Spot 14. Compositions and methods for treating breast cancer are also provided. | 06-23-2011 |
| 20110118336 | Microrna-21 antagonists and its target PDCD4 for use in the treatment of a glioma - The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma. | 05-19-2011 |
| 20110091484 | Compositions and methods for preventing or treating a viral infection - The present invention is a composition for enhancing the immunogenicity of viral vaccine. The composition encompasses a viral vaccine in combination with at least one toll-like receptor and, in particular embodiments, an anti-CD40 antibody. The compositions of the instant invention find application in the prevention or treatment of a viral infection. | 04-21-2011 |
| 20110086022 | Methods for diagnosing and treating neuroendocrine cancer - The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed. | 04-14-2011 |
| 20100010072 | MICRORNA BIOMARKERS FOR HUMAN BREAST AND LUNG CANCER - The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer. | 01-14-2010 |
| 20080268487 | Method For Identifying Agents Which Modulate GtpPase Activity Involved in Insulin-Stimulated Glut4 Translocation - The present invention is a method for identifying agents that modulate the GTPase activity of AS160. In the instant assay, AS160 or the GAP domain thereof is contacted with a test agent, in the presence of GTP-bound Rab (2A, 8A, 8B, 10, or 14), and the AS160 GAP domain-mediated hydrolysis of GTP to GDP is monitored. | 10-30-2008 |
| 20080233195 | SYNTHETIC TRITERPENOIDS AND TRICYCLIC-BIS-ENONES FOR USE IN STIMULATING BONE AND CARTILAGE GROWTH - The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34. | 09-25-2008 |
| 20080220057 | THERAPEUTIC COMPOUNDS AND METHODS OF USE - Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis. | 09-11-2008 |
