Trojan Technologies, Ltd. Patent applications |
Patent application number | Title | Published |
20130022966 | Methods of Treating Cancer Using Notch Pathway Inhibitors - The present invention is based on the discovery that the Notch signaling pathway is associated with cancer. Accordingly, the invention provides methods and compositions for treating cancer. Also provided are methods of modulating the expression and/or activity of proteins in the Notch signaling pathway for use in diagnoses and treatment of cancer in a subject. | 01-24-2013 |
20100266592 | THERAPEUTIC ANTENNAPEDIA-ANTIBODY MOLECULES AND METHODS OF USE THEREOF - The present invention is based on the seminal discovery that an antibody or fragment thereof combined with Antennapedia or a fragment thereof, is an effective therapeutic agent. The invention describes the construction of antibody or antibody fragment fused or chemically conjugated with Antennapedia at its carboxyl or its amino terminus (a “cargo-carrier” construct). | 10-21-2010 |
20100190691 | DELIVERY OF NUCLEIC ACIDS USING CELL-PENETRATING PEPTIDES - The present invention is based on the innovative concept of conjugating a cell-penetrating peptide (CPP), including a protein transduction domain, to a nucleic acid molecule to provide a nucleic acid-protein conjugate exhibiting enhanced cellular uptake. Accordingly, the invention provides a method of producing a cell permeable nucleic acid molecule conjugate nucleic acid including a nucleic acid conjugated with a homeodomain of an antennapedia homeotic transcription factor protein (Antp), or functional fragment thereof. The invention further provides compositions and methods treating a subject using the conjugates produced by the method described herein. | 07-29-2010 |