| Translational Genomics Research Institute Patent applications |
| Patent application number | Title | Published |
|---|
| 20130122497 | THERAPEUTIC TARGETS FOR ADRENOCORTICAL CARCINOMA - This invention identifies and provides a recurrent translocation t(4;8) (p16.2; p23.1) associated with Adrenocortical Carcinoma, and diagnostic methods using the translocation by FISH hybridization or PCR based assays. | 05-16-2013 |
| 20130116196 | MUSCLE FATIGUE SUBSTANCE CYTOKINES AND METHODS OF INHIBITING TUMOR GROWTH THEREWITH - Compositions and methods for inhibiting tumor growth and tumor cell proliferation are provided. In general, the cytokines useful with the present invention are selected from the group consisting of LIX (or CXCL | 05-09-2013 |
| 20120264720 | IDENTIFICATION AND TREATMENT OF CANCER SUBSETS - Methods of predicting whether or not a tumor will be responsive to IP6 treatment, methods of treating patients with cancer using IP6, methods of predicting the progression of a disease, and kits that facilitate these methods are disclosed. | 10-18-2012 |
| 20120264135 | METHOD OF DETECTING COCCIDIOIDES SPECIES - The present invention provides methods and kits that may be used to detect and quantify the presence of | 10-18-2012 |
| 20120252753 | THERAPEUTIC TARGET FOR PANCREATIC CANCER CELLS - This invention provides a therapeutic target for pancreatic cancer. The invention further provides methods of screening of new therapeutic agents using the target. The invention also provides a pharmaceutical composition comprising fasudil or derivatives thereof for pancreatic cancer treatment, and a kit comprising such a pharmaceutical composition. | 10-04-2012 |
| 20120245188 | METHODS OF TREATING MEMORY LOSS AND ENHANCING MEMORY PERFORMANCE - The present invention provides methods and compositions for enhancing working memory impaired due to aging, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, alcoholism or alcohol withdrawal or Huntington's disease using p38 MAPK inhibitor such as SB239063. | 09-27-2012 |
| 20120245044 | METHODS OF DETERMINING CHEMOTHERAPY RESPONSE IN CANCER - This disclosure provides a biomarker profile, which is linked to cancer cell chemo-resistance. The disclosure further provides methods of diagnosis and theranosis, and screening of new therapeutic agents using these biomarkers in the profile, and kits for employing these methods and compositions. | 09-27-2012 |
| 20120142922 | BENZAMIDE DERIVATIVES - Disclosed are benzamide derivatives useful in slowing the expansion of cancer cells. | 06-07-2012 |
| 20110263439 | MARKERS ASSOCIATED WITH ALZHEIMER'S DISEASE - This application discloses SNPs capable of predicting increased or decreased risk of developing late onset Alzheimer's disease. | 10-27-2011 |
| 20100010797 | METHOD FOR DETERMINING THE EFFECTS OF EXTERNAL STIMULI ON BIOLOGICAL PATHWAYS IN LIVING CELLS - The present invention describes methods for carrying out experiments on living cells, including making measurements of the operation transcriptional regulatory processes and indicators of the kinds of processes operating in the cell in response to external stimuli. Image analysis allows for gathering data concerning the flow of information through a cell's genomic regulatory network as it is executing a programmatic change in its activities as a function of said stimuli. The method also allows collection of data of the results of the information-processing in the cell by observing the decisions the cell makes when modulating cellular process activities. | 01-14-2010 |
| 20090260092 | METHODS OF DIAGNOSING ALZHEIMER'S DISEASE AND MARKERS IDENTIFIED BY SET ASSOCIATION - The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD. | 10-15-2009 |
| 20090249498 | Methods of diagnosing alzheimer's disease and markers identified by set association - The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD. | 10-01-2009 |
| 20080280777 | Method for determining the effects of external stimuli on biological pathways in living cells - The present invention describes methods for carrying out experiments on living cells, including making measurements of the operation transcriptional regulatory processes and indicators of the kinds of processes operating in the cell in response to external stimuli. Image analysis allows for gathering data concerning the flow of information through a cell's genomic regulatory network as it is executing a programmatic change in its activities as a function of said stimuli. The method also allows collection of data of the results of the information-processing in the cell by observing the decisions the cell makes when modulating cellular process activities. | 11-13-2008 |
