| Toolgen, Inc. Patent applications |
| Patent application number | Title | Published |
|---|
| 20100215621 | Recombinant Adenoviruses Capable Of Regulating Angiogenesis - The present invention relates to a recombinant adenovirus capable of regulating angiogenesis, which comprises (a) an adenoviral ITR (inverted terminal repeat) nucleotide sequence; and (b) a transcription regulatory sequence for a VEGF-A (vascular endothelial growth factor-A) gene comprising (i) a nucleotide sequence encoding a DNA binding domain comprising a zinc finger domain to bind to a site in a VEGF-A promoter sequence as set forth in nucleotides 1-2362 of SEQ ID NO:1, and (ii) a transcription activation domain or a transcription inhibitory domain linked to the nucleotide sequence encoding the DNA binding domain; and a pharmaceutical composition comprising the recombinant adenovirus. | 08-26-2010 |
| 20090176653 | ZINC FINGER DOMAIN LIBRARIES - Disclosed are libraries of chimeric zinc finger domains. The libraries can include two or more zinc finger domains from naturally occurring proteins, e.g., mammalian proteins and particularly human proteins. Useful chimeric zinc finger domains can be identified from the library. Also disclosed are the amino acid sequences of zinc finger domains that recognize particular sites. | 07-09-2009 |
