TOKYO WOMEN'S MEDICAL UNIVERSITY Patent applications |
Patent application number | Title | Published |
20150283364 | SHEET SHAPED THERAPEUTIC SUBSTANCE TRANSFER APPARATUS AND METHOD OF AFFIXING SHEET SHAPED THERAPEUTIC SUBSTANCE - With the present invention the sheet shaped therapeutic substance can be accurately and easily affixed to the inside of the human body. As shown in FIG. | 10-08-2015 |
20150283235 | IMMUNE-TOLERANCE INDUCER - The purpose of the present invention is to create an immune tolerance-inducing agent used in therapy in which donor hematopoietic cells are transplanted into a recipient in order to induce immune tolerance in the recipient with respect to donor cells, tissue, or organs. By using an alpha-galactosylceramide-containing liposome in combination with a costimulatory-pathway-blocking substance, hematopoietic chimerism can be induced in the recipient by transplantation of donor hematopoietic cells, making it possible to induce immune tolerance in the recipient with respect to donor cells, tissue, or organs. | 10-08-2015 |
20150252315 | CELL CULTURE APPARATUS AND CELL CULTURE METHOD USING THE SAME - Disclosed herein is a cell culture apparatus that can achieve appropriate culture conditions. The cell culture apparatus ( | 09-10-2015 |
20150118745 | CELL CULTURE SYSTEM AND CELL CULTURE METHOD - A cell culture system having a cell culture vessel, a composition controlling fluid storage vessel, a culture fluid composition controlling means having an inlet and an outlet for a cell culture fluid, an inlet-connected fluid feeding circuit from the cell culture vessel to the inlet of the culture fluid composition controlling means, an outlet-connected fluid feeding circuit from the cell culture vessel to the outlet of the culture fluid composition controlling means, a means which perfuses the cell culture fluid from the inlet-connected fluid feeding circuit to the outlet-connected fluid feeding circuit through the culture fluid composition controlling means, and a means which controls the amount of fluid in the cell culture vessel, in which compositions of the cell culture fluid in the cell culture vessel and compositions of the composition controlling fluid in the composition controlling fluid storage vessel can be controlled in a continuous manner. | 04-30-2015 |
20150072877 | COMPOSITION FOR TREATMENT OF PANCREATIC CANCER - Disclosed is a composition for treating pancreatic cancer. The composition comprises a pharmaceutically effective amount of an antisense nucleic acid or siRNA that inhibits expression of at least one gene selected from the group consisting of SON gene, MCM5 gene, WDR5 gene, PBK gene and CENPA gene. The composition inhibits the expression of a specific gene to provide the effect of inhibiting the proliferation, survival and tumorigenicity of pancreatic cancer cells. | 03-12-2015 |
20150072370 | METHOD OF EVALUATING WETTING CHARACTERISTIC OF OBJECT - Provided is a means for evaluating the wetting characteristic of an object such as a cell sheet and a culture dish in a non-contact fashion. The wetting characteristic of an object is evaluated by a method comprising the steps of: (1) removing a liquid by jetting a gas at a surface of the object covered with the liquid, (2) measuring a dimension of a region in which the liquid is removed after the completion of the gas jetting and (3) evaluating the wetting characteristic of the object using the measured dimension as an index. | 03-12-2015 |
20140343369 | OPERATION-MODE INDICATING SYSTEM FOR BODY SUPPORT APPARATUS, AND BODY SUPPORT APPARATUS - In an operation-mode indicating system, a first light emitting device is located within a peripheral visual field of an operator and is controllably connected to a controller. The peripheral visual field is defined around a center visual field of the operator while the operator is looking at a predetermined site. A body support apparatus is capable of performing an operation to the predetermined site. The controller controls the first light emitting device to emit first light in a first operation mode of the body support apparatus and second light in a second operation mode of the body support apparatus. The first light and the second light are visually distinguishable from each other. | 11-20-2014 |
20140335610 | CELL CULTURE SUBSTRATE, AND METHOD FOR MANUFACTURING SAME - A cell culture substrate is used comprising a photopolymerization initiator immobilized on a surface of the cell culture substrate, and a linear polymer immobilized on a part or the entirety of the surface via the photopolymerization initiator, and wherein the photopolymerization initiator is thioxanthone. Thereby, advantageously, a single type or multiple types of cells are efficiently cultured on specific regions of the culture substrate, and efficiently detached only by changing temperature on the surface of the substrate. | 11-13-2014 |
20140306086 | APPARATUS FOR SUPPORTING AND FOLLOWING MOVEMENT OF A PART OF PERSON'S BODY - An apparatus includes a brace being mounted on a person's body part and having a hard fitting surface. The apparatus also includes a load device, a support, a securing member, a brake, a switch device, and a soft film. The load device has a hard receiving surface receiving the fitting surface of the brace. The support movably supports the load device. The securing member secures the fitting surface to the receiving surface and enables the load device to move and follow movement of the person's body part and the brace against resistance applied from the support. The brake limits movement of the load device. The switch device switches operation modes of the apparatus, at least, between a free mode and a limiting mode. The soft film is arranged between the receiving and fitting surfaces for smooth movement of the person's body part on the load device in the limiting mode. | 10-16-2014 |
20140124445 | TEMPERATURE-RESPONSIVE MONOLITHIC POROUS BODY, METHOD FOR PRODUCING SAME, AND TEMPERATURE-RESPONSIVE CHROMATOGRAPHY METHOD USING SAME - A temperature responsive monolithic porous material is obtained that comprises a polymer having a hydration ability that changes in a temperature range of 0 to 80° C. and being immobilized to a surface of the porous material at a high density by binding an atom transfer radical polymerization initiator to a surface of the porous material, and inducing a growth reaction of a polymer, having a hydration ability that changes in a temperature range of 0 to 80° C., from the initiator using an atom transfer radical process under a presence of a catalyst. | 05-08-2014 |
20140112892 | SYNTHESIS AND ANALYSIS OF NOVEL COMPOUND CAPABLE OF INDUCING DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELL INTO HEPATOCYTE - The purpose is to select low-molecular-weight compounds which are effective in inducing differentiation of mesenchymal stem cell into hepatocyte and to develop a safe differentiation-inducing method having excellent efficiency of differentiating mesenchymal stem cell into hepatocyte. Provided are at least one compound selected from the group consisting of compounds represented by formulae (1) and (2), a salt thereof, or a solvate of them; a differentiation inducer comprising at least one compound selected from the group consisting of compounds represented by formulae (1) and (2), a salt thereof, or a solvate of them; and a differentiation inducer comprising a compound represented by formula (8), a salt thereof, or a solvate of them. | 04-24-2014 |
20140072599 | CYTOKINE-PRODUCING CELL SHEET AND METHOD FOR USING THE SAME - The types and relative proportions of cells constituting a cell sheet stack, and the number of cells to be seeded are altered to change the state of the cells in the cell sheet stack, whereby production of an angiogenesis-promoting cytokine as well as construction of a vascular endothelial network can be optimized. | 03-13-2014 |
20130289723 | MIDDLE EAR MUCOSA-LIKE CELL SHEET, PROCESS OF PRODUCING THE SAME AND METHOD OF USING THE SAME - The purpose of the present invention is to obtain an alternative to a substitute of the mucosa in the middle ear which is engrafted on the surface of the bone in the middle ear, hyperplasia of the granulation tissue and the bone and the development of the fibroblast cell sir the middle ear are suppressed, and to obtain a middle ear mucosa-like cell sheet retaining cilia in the surface layer, comprising culturing nasal epithelium cells on a cell culture substrate coated with a polymer whose hydration force changes within a temperature range of 0 to 80 ° C., wherein the cells are cultured within a temperature range where the hydration force of the polymer is weak, and then changing the temperature to a temperature at which the hydration force is strong to recover the cultured cell sheet. | 10-31-2013 |
20130288982 | THERAPEUTIC AGENT FOR PULMONARY SMALL CELL CARCINOMA - The invention aims to clarify further functions of a T-cell leukemia translocation-associated gene (TCTA) protein-derived peptide and provide a novel application of the peptide. The invention provides a therapeutic agent for pulmonary small cell carcinoma or a cell growth inhibitor of pulmonary small cell carcinoma, comprising any peptide described in SEQ ID NOs 1 to 5. | 10-31-2013 |
20130280260 | OSTEOCLASTOGENESIS INHIBITOR CONTAINING ANTI-VDAC ANTIBODY - The present invention provides a therapeutic agent or a preventative agent containing anti-VDAC antibody for diseases in which there is increased activation of osteoclasts, such as rheumatoid arthritis, and an inhibitor of human osteoclast formation containing anti-VDAC antibody. | 10-24-2013 |
20130260445 | MEASURING UNIT TO BE ATTACHED TO CELL CULTURE CONTAINER, CELL CULTURE CONTAINER, AND CULTIVATION CONDITION MONITORING SYSTEM - A measuring unit which is to be attached to a cell culture container configured to accommodate cells to be cultured and a culture solution, includes: a measurer which is configured to measure information related to the cells and the culture solution, in a non-contact manner; and a sensor which is configured to detect at least one of a position, a posture, an impact, an orientation, and vibration. | 10-03-2013 |
20130255374 | METHOD AND APPARATUS FOR MEASURING LIQUID LEVEL OF CELL CULTURE SOLUTION - A method of measuring a liquid level of a cell culture solution stored in a cell vessel, includes: irradiating the cell culture solution with at least two kinds of light beams including a first light beam having a first wavelength and a second light beam having a second wavelength; measuring a first absorbance of the cell culture solution with respect to the first light beam, and a second absorbance of the cell culture solution with respect to the second light beam; and determining a liquid level of the cell culture solution based on the first absorbance and the second absorbance. | 10-03-2013 |
20130173018 | METHOD FOR MANUFACTURING MULTILAYERED CELL SHEET, MULTILAYERED CELL SHEET HAVING VASCULAR NETWORK OBTAINED THEREBY, AND METHOD OF USE THEREOF - A method for manufacturing a multilayered cell sheet characterized in fabricating a vascular bed that constructs a vascular network extending to the surface from a channel for perfusing a medium, the channel being embedded in a gel; and layering a cell sheet onto the vascular bed to construct a vascular network in the cell sheet. This manufacturing method makes it possible to construct a vascular network in the cell sheet and to fabricate a thick multilayered cell sheet in a simple manner by layering cell sheets. Such a thick multilayered cell sheet is useful as an in-vivo tissue substitute in regenerative medicine involving a variety of tissues. | 07-04-2013 |
20130171213 | METHOD FOR MANUFACTURING MULTILAYERED CELL SHEET, MULTILAYERED CELL SHEET HAVING VASCULAR NETWORK OBTAINED THEREBY, AND METHOD OF USE THEREOF - A method tor producing multilayered cell sheets, including producing a vascular bed which includes an artery-vein loop and in which a capillary vascular network is constructed; layering cell sheets on the vascular bed; and perfusing a culture medium in vitro to construct a vascular network in the cell sheets. The production method enables vascular networks to he constructed in cell sheets and enables thick multilayered cell sheets to foe easily produced by layering the cell sheets. Such thick multilayered cell sheets are useful as in vivo tissue-like products for regenerative medicine for various tissues and for evaluation of drugs and the like. | 07-04-2013 |
20130130361 | PROCESSING SYSTEM FOR CELL CULTURES AND MODULE CONNECTING METHOD OF PROCESSING SYSTEM FOR CELL CULTURES - A processing system for cell cultures for carrying out cell/tissue culturing processes in the field of regenerative medicine, etc. which is a processing system for cell cultures which prevents viruses and human-derived cells, etc. other than a culturing processing target from entering the interior of a closed space from outside of the system to maintain sterility, maintains sealability of the closed spaces of modules, and couples or detaches the plurality of modules in accordance with a wide variety of cell culturing processing steps so that cell culturing processes can be carried out by combining the plurality of culturing processing modules is provided. | 05-23-2013 |
20130028813 | Cell Isolation Instrument - A cell isolation instrument includes: a first container which has an opening in an upper portion; a filtration member which defines at least a part of a lower portion of the first container; an isolation member which is movably housed in the first container to collide with a tissue, thereby isolating cells; and a second container which houses the first container in a manner that the first container can be taken out. | 01-31-2013 |
20120252110 | CELL CULTURE APPARATUS - A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of the sterile space and an outside of the sterile space communicate with each other, the delivery flow path configured to limit a flow in the delivery flow path to a direction that is directed from the inside of the sterile space toward the outside of the sterile space; and a culture solution delivering section configured to deliver the sampled culture solution to the outside of the sterile space via the delivery flow path. | 10-04-2012 |
20120232248 | THERAPEUTIC AGENT FOR PULMONARY SMALL CELL CARCINOMA - The invention aims to clarify further functions of a TCTA protein-derived peptide and provide a novel application of the peptide. The invention provides a therapeutic agent for pulmonary small cell carcinoma or a cell growth inhibitor of pulmonary small cell carcinoma, comprising any peptide described in SEQ ID NOs 1 to 5. | 09-13-2012 |
20120214250 | METHOD AND APPARATUS FOR MEASURING PH OF SOLUTION - A method of measuring a pH of a solution includes: emitting light beams of two wavelengths from one side of a measuring region of a solution into which an indicator is mixed, while pulsating the solution in the measuring region; receiving at least one of transmitted light beams and reflected light beams of the emitted light beams on the other side of the measuring region, while pulsating the solution in the measuring region; obtaining absorbances of the two wavelengths based on the received at least one of the transmitted light beams and the reflected light beams; obtaining an absorbance ratio from the obtained absorbances ; and calculating a pH value of the solution based on the obtained absorbance ratio and an absorbance ratio/pH value correspondence database which is previously stored. | 08-23-2012 |
20120189636 | HUMAN SERUM AMYLOID-A3 ANTIBODY AND USE THEREOF - The objective of the invention is to prepare an antibody to human SAA3 whose in vivo presence has not yet been identified in humans, thereby revealing the presence of in vivo human SAA3 and the relationship between human SAA3 and disease, and also to provide a method for treating such disease. More specifically our objective is to create an antibody to counter human serum amyloid-A3 and a kit for detecting and measuring human serum amyloid-A3 employing the aforementioned antibody, as well as a therapeutic cancer agent that can be utilized in methods to treat and diagnose cancer. | 07-26-2012 |
20110207220 | CELL PATTERN RECOVERY TOOL - This invention provides a cell pattern recovery tool comprising a base material layer having a surface subjected to easy adhesion treatment, a temperature responsive polymer layer that is provided on the base material layer and has a surface subjected to silane treatment, and a cell adhesion inhibiting material layer provided on the temperature responsive polymer layer. According to the present invention, a cell pattern can be rapidly recovered while maintaining the cell pattern stably and reliably under minimally invasive conditions for the cells. | 08-25-2011 |
20110104656 | ARTIFICIAL KIDNEY PRECURSOR AND PROCESS FOR PRODUCTION THEREOF - The present invention provides an artificial kidney precursor containing a non-human mammalian metanephros separated out from a living body, wherein the metanephros has been subjected to freezing and thawing treatments outside a living body, and contains mammalian mesenchymal stem cells transferred outside a living body, and a method of production thereof. | 05-05-2011 |
20100055791 | MATRIX FOR REGENERATING CARDIOVASCULAR TISSUE AND METHOD FOR REGENERATING CARDIOVASCULAR TISSUE - Materials for culturing cardiovascular tissues wherein a sponge made of a bioabsorbable material is reinforced with a reinforcement made of a bioabsorbable material. | 03-04-2010 |
20080294093 | THERAPEUTIC-SUBSTANCE CARRYING/ADMINISTERING APPLIANCE - A therapeutic-substance carrying/administering appliance includes a cylindrical outer sheath; a slide member installed in the cylindrical outer sheath to be slidable therein; and a sheet supporting member, connected to a distal end of the slide member and made of a resilient material, for supporting a sheet-shaped therapeutic substance. The sheet supporting member is held in a flat unrolled shape in a free state in which the sheet supporting member projects outwardly from a distal end of the cylindrical outer sheath. When the sheet supporting member is in the free state, sliding the slide member in a retracting direction causes the sheet supporting member to contact the distal end of the cylindrical outer sheath, and subsequently further moving the slide member in the retracting direction causes the sheet supporting member to be retracted into the cylindrical outer sheath while being deformed into a tubular shape. | 11-27-2008 |