TOCAGEN INC. Patent applications |
Patent application number | Title | Published |
20140242033 | GENE THERAPY VECTORS AND CYTOSINE DEAMINASES - This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders. | 08-28-2014 |
20140178854 | ANTISERA ASSAYS FOR MLV RELATED VIRUSES IN HUMANS AND OTHER MAMMALS - The disclosure provide cell lines and methods for the production of vectors and viral particles useful in diagnostics and therapeutics. | 06-26-2014 |
20130323301 | ENHANCED CANCER TREATMENT AND MONITORING USING RECOMBINANT VECTORS - This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics. | 12-05-2013 |
20130266931 | RETROVIRUS DETECTION - Provided are methods and compositions useful for detecting viral infection or contamination in a biological sample. | 10-10-2013 |
20130130986 | CANCER TREATMENT WITH RECOMBINANT VECTOR - This disclosure provides modified cytosine deaminases(CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders. It further provides use of such modified CDs with a thymosin-alpha-1 polypeptide in the treatment of disease and disorders. | 05-23-2013 |
20120087894 | PRODUCER CELLS FOR REPLICATION COMPETENT RETROVIRAL VECTORS - The disclosure provide cell lines and methods for the production of vectors and viral particles useful in gene therapy. | 04-12-2012 |
20110287020 | RECOMBINANT VECTORS - This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders. | 11-24-2011 |
20110268720 | FORMULATIONS OF 5-FLUOROCYTOSINE AND USES THEREOF - The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method comprises administering to a subject in need thereof a fungus-treating effective amount of a composition comprising 5-fluorocytosine. In yet another aspect, a method of treating a cancer is provided. The method comprises administering to a subject in need thereof a sufficient amount of an expression vector to induce expression of cytosine deaminase which is capable of converting 5-fluorocytosine to 5-fluorourcail in cells of the cancer and a cancer-treating effective amount of a composition comprising 5-fluorocytosine. | 11-03-2011 |
20110217267 | GENE THERAPY VECTORS AND CYTOSINE DEAMINASES - This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders. | 09-08-2011 |