THERMO FISHER SCIENTIFIC BIOSCIENCES INC. Patent applications |
Patent application number | Title | Published |
20140213639 | Optimization of Vectors for Effective Delivery and Expression of Genetic Content - Lentiviral vectors, plates, kits and methods are provided that permit improved efficiency for selection of a promoter sequence for use in a lentiviral application. Through various embodiments of the present invention, a researcher may first evaluate and then choose in a modular fashion, a vector comprising a promoter that is effective for expression in a particular cell line or type. | 07-31-2014 |
20140193914 | Introduction of Modular Vector Elements During Production of a Lentivirus - Methods and kits for lentiviral production are provided. By separating certain components of the vector including but not limited to promoter, reporter and selection marker preference components from the genetic content of interest, one can create libraries that allow for the efficient generation of custom selected lentiviral vectors. | 07-10-2014 |
20140148362 | Methods and Compositions for Selecting siRNA of Improved Functionality - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR. | 05-29-2014 |
20140094390 | siRNA Targeting TIE-2 - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed. | 04-03-2014 |
20140066595 | Modulators of Protein Production in a Human Cell Line and Cell-free Extracts Produced Therefrom - Cell-free extracts, methods for producing these extracts, methods for using these extracts, compositions that facilitate production of these extracts and kits that contain these extracts are provided. By increasing or decreasing certain gene products through, for example, the use of siRNA or mimics, one can develop mammalian cell-free extracts that have desired levels of efficiency. | 03-06-2014 |
20140031414 | SIRNA TARGETING VEGFA AND METHODS FOR TREATMENT IN VIVO - Vascular endothelial growth factor A (VEGFA) is a chemical signal produced by cells that stimulates the growth of new blood vessels, and overexpression of VEGFA can lead to undesirable physiological conditions. Through the identification of new siRNA and modifications that improve the silencing ability of these siRNA in vivo, therapeutic compositions and methods have been invented to address the problems associated with this overexpression. | 01-30-2014 |