| THE WASHINGTON UNIVERSITY Patent applications |
| Patent application number | Title | Published |
|---|
| 20120077682 | COMPOSITIONS AND METHODS FOR DETECTING CANCER METASTASIS - The present invention encompasses compositions and methods for detecting cancer metastasis. | 03-29-2012 |
| 20120059308 | PERIPHERAL NERVE BLOCK CATHETER - An anesthetic nerve block catheter and methods of using the anesthetic nerve block catheter to perform a nerve block or continuous nerve block procedure are disclosed. | 03-08-2012 |
| 20120041303 | PHAGE ANTIBODIES TO RADIATION-INDUCIBLE NEOANTIGENS - A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor. | 02-16-2012 |
| 20120035359 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF - The present invention encompasses phenoxazine derivatives and methods of use thereof. | 02-09-2012 |
| 20120015990 | TASPASE1 INHIBITORS AND THEIR USES - Provided herein are small molecule inhibitors of Taspase1 and methods of using the small molecule inhibitors of Taspase1 to treat neoplasm in subjects in need thereof. | 01-19-2012 |
| 20110294138 | METHODS FOR SIMULTANEOUSLY MEASURING THE IN VIVO METABOLISM OF TWO OR MORE ISOFORMS OF A BIOMOLECULE - The present invention encompasses methods for the simultaneous measurement of the in vivo metabolism of two or more isoforms of a biomolecule. The biomolecule is typically produced in the central nervous system. | 12-01-2011 |
| 20110236401 | COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY - The invention derives from the identification of HVEM as the native ligand for BTLA. The invention provides compositions and methods for modulating BTLA-HVEM interactions and BTLA and HVEM activity, which are useful for modulating immune responses. Agonists and antagonists of the BTLA-HVEM interaction are provided, and methods of treating a variety of conditions through the modulation of immune responses are provided. | 09-29-2011 |
| 20110231100 | ROTATIONAL SEISMOMETER FOR NEAR-FIELD MEASUREMENTS - A rotational seismometer having a housing that encases an optical lever having a light source for emitting a beam of light through a slit defined by the optical lever that is focused by a lens for focusing the beam of light to a balance bob suspended within the housing is disclosed. The balance bob includes a mirror secured to a plate attached to the housing through an arrangement that includes a thin fiber attached to a stiff wire such that the stiff wire bends and the thin wire does not bend when a tilt motion is applied to the rotational seismometer. | 09-22-2011 |
| 20110230647 | COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY - The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided. | 09-22-2011 |
| 20110206696 | METHODS FOR INHIBITING BONE LOSS AND BONE METASTASIS - The invention encompasses methods of inhibiting bone loss and bone metastasis. | 08-25-2011 |
| 20110185591 | MULTI-PLUG DESIGN SHOE INSOLE - An insole is provided for reducing peak plantar pressure on a foot. The insole includes a compressible pad having a plurality of holes extending from a bottom surface of the compressible pad and partially through the compressible pad. A plurality of compressible plugs is disposed in the plurality of holes, wherein the plurality of compressible plugs has a stiffness that is different than a stiffness of the compressible pad. The plurality of compressible plugs is concentrated in a reduced stiffness portion of the compressible pad that substantially corresponds to an area of peak plantar pressure on the foot. | 08-04-2011 |
| 20110177976 | METHODS FOR PROMOTING WEIGHT LOSS AND ASSOCIATED ARRAYS - Methods of modulating body fat or weight loss are presented Nucleic acid and protein microarrays that comprise biomolecules associated with an obese host microbiome or a lean host microbiome are utilized for analysis. | 07-21-2011 |
| 20110177509 | RISK FACTORS AND A THERAPEUTIC TARGET FOR NEURODEGENERATIVE DISORDERS - Compositions and methods for detecting a neurodegenerative disorder, and methods of treating a neurogenerative disorder are disclosed. Biomarkers for a neurodegenerative disorder containing a polymorphism in the nucleotide sequence of PP3R1, GSK3beta, PPP3CA, FYN, WISP1, MGEA5, CTSD, F2, MAPT, OGT or PRKCA are also disclosed. A method for detecting a neurodegenerative disorder by detecting polymorphisms in the above genes is further disclosed. | 07-21-2011 |
| 20110143380 | ALZHEIMER'S DISEASE BIOMARKERS AND METHODS OF USE - The invention encompasses biomarkers for AD, a method for detecting AD, a method of monitoring AD, and a kit for quantifying biomarkers for AD. | 06-16-2011 |
| 20110143344 | GENETIC POLYMORPHISMS AND SUBSTANCE DEPENDENCE - The invention encompasses methods for identifying subjects at risk for substance dependence by detecting the presence of polymorphism in the CHRNA5-CHRNA3-CHRNB4 gene cluster and the CHRNA4 gene. The invention also encompasses determining the response of a subject to a therapeutic substance, treating substance dependence in a subject, and evaluating the response of a subject to a substance cessation treatment. | 06-16-2011 |
| 20110124525 | METHOD FOR PREDICTING RISK OF METASTASIS - The invention encompasses methods and compositions for predicting the risk of metastasis. In particular, the invention encompasses a method for correlating the the level of expression of one or more nucleic acid sequences with a risk of metastasis. | 05-26-2011 |
| 20110123450 | MACROCYCLIC CYANINE AND INDOCYANINE BIOCONJUGATES PROVIDE IMPROVED BIOMEDICAL APPLICATION - The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing compounds as contrast agents. Novel macrocyclic cyanine and indocyanine bioconjugates that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These compounds are especially useful for endoscopic, localized photoacoustic, and sonofluorescence imaging, detection and therapy of tumors and other abnormalities. | 05-26-2011 |
| 20110123438 | UNIVERSAL ANCHOR PEPTIDE FOR NANOPARTICLES - The present invention provides a substantially non-lytic, non-cytotoxic anchor peptide that is capable of stably inserting into lipid membranes. In particular, the invention provides nanoparticles comprising stably inserted anchor peptides, which may be conjugated to a variety of different cargo complexes. | 05-26-2011 |
| 20110111511 | METHODS FOR MEASURING THE METABOLISM OF NEURALLY DERIVED BIOMOLECULES IN VIVO - The present invention relates to methods of diagnosing, monitoring, and assessing treatment effects for neurological and neurodegenerative diseases and disorders, such as Alzheimer's Disease, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms. Methods of measuring the in vivo metabolism of biomolecules produced in the CNS in a subject are provided. | 05-12-2011 |
| 20110065635 | METHODS AND COMPOSITIONS FOR MODULATING INSULIN REGULATION - The present invention provides a combination of compounds capable of modulating xenin activity and, insulin secretion and weight gain. The invention also provides methods for modulating GIP activity and insulin secretion in a subject, by modulating xenin activity in the subject. | 03-17-2011 |
| 20110065600 | SEQUENCES ASSOCIATED WITH TDP-43 PROTEINOPATHIES AND METHODS OF USING THE SAME - Nucleic acids and peptides and methods of using thereof to identify subjects at risk for a TDP-43 proteinopathy are disclosed An array is also disclosed which contains the nucleic acids and peptides | 03-17-2011 |
| 20110053847 | METHODS OF TREATING VASODILATORY SHOCK - The invention encompasses methods of decreasing the lumenal diameter of a blood vessel by contacting the vessel with a myosin light chain phosphatase inhibitor. | 03-03-2011 |
| 20110038797 | METHOD FOR DETECTING INFLAMMATORY DISORDERS OF THE CENTRAL NERVOUS SYSTEM - The present invention provides a biomarker for a central nervous system inflammatory disorder. The present invention also provides processes for detecting a central nervous system inflammatory disorder and processes for monitoring the effectiveness of a therapeutic treatment for a central nervous system inflammatory disorder. | 02-17-2011 |
| 20100317084 | RECOMBINANT BACTERIA COMPRISING VECTORS FOR EXPRESSION OF NUCLEIC ACID SEQUENCES ENCODING ANTIGENS - The invention encompasses a recombinant bacterium that comprises at least one vector capable of expressing a nucleic acid sequence encoding an antigen. In particular, the bacterium comprises at least one chromosomally encoded essential nucleic acid that is altered so that it is not expressed, and at least one extrachromosomal vector. | 12-16-2010 |
| 20100310582 | METHODS FOR INDUCING IN VIVO TOLERANCE - The present invention encompasses methods for inducing in vivo tolerance to a foreign tissue. | 12-09-2010 |
| 20100310580 | COMPOSITIONS AND METHODS FOR TREATING PRURITUS - The present invention encompasses methods and compositions for alleviating pruritis. The compositions may comprise an analgesic agent. | 12-09-2010 |
| 20100297677 | CYCOCHROME C SYNTHESIS INHIBITORS - The invention provides methods for identifying a compound that inhibits cytochrome c synthesis. This invention further provides a method for the high throughput screening of compounds that inhibit cytochrome c synthesis. | 11-25-2010 |
| 20100297019 | PARTICLES FOR IMAGING - The invention encompasses particles comprising metal atoms, methods of making the particles, and methods for using the particles. In particular, the particles may be used to image biological tissues or to deliver a bioactive agent. | 11-25-2010 |
| 20100297007 | LIGAND DIRECTED TOROIDAL NANOPARTICLES FOR THERAPY AND DIAGNOSTIC IMAGING - The present invention provides nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to deliver therapeutic agents and/or imaging agents. | 11-25-2010 |
| 20100278724 | INHIBITION OF MIGRATION AND INDUCTION OF CELL DEATH BY THE TYPE II COLLAGEN AMINO PROPEPTIDES - The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an αvβ3 and/or an αvβ5 integrin. | 11-04-2010 |
| 20100267574 | PREDICTING LUNG CANCER SURVIVAL USING GENE EXPRESSION - The present invention provides a plurality of biomarkers for predicting survival of a subject with a lung cancer. More specifically, the present invention relates to methods of predicting survival of a subject with a lung cancer, a kit for predicting survival of a subject with a lung cancer, and an array for predicting survival of a subject with lung cancer. | 10-21-2010 |
| 20100184624 | ARRAYS AND METHODS COMPRISING M. SMITHII GENE PRODUCTS - The present invention encompasses arrays and methods related to the genome of | 07-22-2010 |
| 20100172874 | GUT MICROBIOME AS A BIOMARKER AND THERAPEUTIC TARGET FOR TREATING OBESITY OR AN OBESITY RELATED DISORDER - The present invention relates to the gut microbiome as a biomarker and therapeutic target for energy harvesting, weight loss or gain, and/or obesity in a subject. In particular, the invention provides methods of altering and monitoring the relative abundance of | 07-08-2010 |
| 20100166784 | METHOD AND COMPOSITIONS FOR MODULATING TH17 CELL DEVELOPMENT - The invention encompasses methods and compositions for modulating Th17 development. | 07-01-2010 |
| 20100159468 | SMALL MOLECULE INHIBITION OF INTRACELLULAR TRANSPORT - The present disclosure characterizes the activity of Golgicide A (GCA), as a potent, specific and reversible small molecule inhibitor of Golgi BFA resistance factor 1 (GBF1) function. A mutant GBF1 gene that is resistant to GCA is also described. Methods of using GCA and the GCA-resistant GBF1 gene are described including methods for modulating GBF1 activity for research and therapeutic purposes. Also described are compositions incorporating a GCA-resistant GBF1. | 06-24-2010 |
| 20100129874 | METHOD FOR MULTIPLEXED NUCLEIC ACID PATCH POLYMERASE CHAIN REACTION - The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction. | 05-27-2010 |
| 20100124558 | REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENTUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY - The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest. | 05-20-2010 |
| 20090291428 | COMPOSITIONS AND METHODS FOR THE DETECTION AND TREATMENT OF POXVIRAL INFECTIONS - The invention encompasses an antibody that binds to and substantially inhibits the activity of at least one poxvirus complement inhibitor. Additionally, the application encompasses methods of detecting a poxvirus complement inhibitor and methods of decreasing the activity of a poxvirus complement inhibitor. | 11-26-2009 |
| 20080319010 | Use of Chloroquine to Treat Metabolic Syndrome - The present invention provides methods and compositions for modulating certain metabolic processes and for treating a variety of disorders associated with metabolic syndrome, including insulin related disorders, ischemia, oxidative stress, atherosclerosis, hypertension, obesity, abnormal lipid metabolism, and stroke by administering an effective dose of a chloroquine compound. The invention also provides methods and compositions relating to administering an effective dose of a chloroquine compound in combination with at least a second pharmaceutically active ingredient or compound including an antihyperglycemic diabetes treatment, an antihypertensive agent, an antithrombotic agent, and/or an inhibitor of cholesterol synthesis or absorption. | 12-25-2008 |
