| THE UNIVERSITY OF TOLEDO Patent applications |
| Patent application number | Title | Published |
|---|
| 20110245167 | NaK-ATPase-Derived Peptide SRC Inhibitors and Ouabain Antagonists and Uses Thereof - A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed. | 10-06-2011 |
| 20110034885 | NEEDLE FOR DIRECTIONAL CONTROL OF THE INJECTION OF BONE CEMENT INTO A VERTEBRAL COMPRESSION FRACTURE - A needle for use in a surgical procedure includes an outer cannula including a shaft portion having a side wall and an end wall. A first aperture extends through the side wall of the outer cannula, and a second aperture extending through the end of the outer cannula. The needle also includes an inner cannula that is disposed within the outer cannula and includes a shaft portion having a bore extending therethrough. The inner cannula is selectively movable relative to the outer cannula between a first orientation and a second orientation. In the first orientation, communication is provided between the bore of the inner cannula and a first external region that is located adjacent to the second end of the outer cannula. In the second orientation, communication is provided between the bore of the inner cannula and a second external region that is located adjacent to the second end of the outer cannula. | 02-10-2011 |
| 20100324094 | Conformationally Restrained Epothilone Analogues as Anti-Leukemic Agents - A method for synthesizing anti-leukemic epothilone analogues includes rigidifying a region between the macrolactone ring and the aromatic side-chain. The anti-leukemic compositions are non-naturally occurring epothilone analogue that are rigidified between the macrolactone ring and the aromatic side-chain. | 12-23-2010 |
| 20100280558 | PEDICLE SCREW ASSEMBLY HAVING A RETRACTABLE SCREW TIP FOR FACILITATING THE SECUREMENT OF THE PEDICLE SCREW ASSEMBLY TO A SPINAL VERTEBRA - A pedicle screw assembly has a retractable screw tip that facilitates the securement of the pedicle screw assembly to a spinal vertebra in a minimally invasive fashion during an orthopedic surgical procedure. The pedicle screw assembly includes a body portion including a head and a shank. The shank includes an outer surface with a thread provided thereon, an end having a cutting tip provided thereon, and a bore extending inwardly from the end and having an internally threaded region provided therein. The pedicle screw assembly also includes a tip portion including a body having a cutting edge and a shank extending from the body. The shank has an externally threaded region provided thereon that cooperates with the internally threaded region of the bore to permit movement of the tip portion relative to the body portion between extended and retracted positions. | 11-04-2010 |
| 20100184667 | MODIFIED PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 MOLECULE AND METHODS BASED THEREON - The present invention relates to a modified plasminogen activator inhibitor type-1 (PAI-1) molecule that displays CN an increased in vivo half-life of the active form of PAI-1, but is deficient in one or more functional activities as compared to the wild-type PAI-1 protein. The modified PAI-1 molecule that displays an increased half-life further displays at least one of the following funtional characteristics: (i) decreased binding activity to at least one of the following molecules: urokinase plasminogen activator (uPA), tissue plasminogen activator (tPA) and vitronectin (Vn); and (ii) decreased specific activity against at least one of the following molecules: uPA, tPA and Vn. The invention further relates to pharmaceutical compositions comprising modified PAI-1 molecules and methods of using these pharmaceutical compositions for treatment. | 07-22-2010 |
| 20100164489 | System for Detecting Nanoparticles Using Modulated Surface Plasmon Resonance - A method and system for detecting magnetic nanoparticles include measuring a magneto-optical enhancement of the plasmon absorption in the optical response. | 07-01-2010 |
| 20100114147 | DIRECTIONAL SOFT TISSUE DILATOR AND DOCKING PIN WITH INTEGRATED LIGHT SOURCE FOR OPTIMIZATION OF RETRACTOR PLACEMENT IN MINIMALLY INVASIVE SPINE SURGERY - A soft tissue dilator for use in a surgical procedure includes a first dilator member that defines a first axis and a second dilator member that defines a second axis. The second dilator member is supported on the first dilator member such that relative rotational movement of the first and second dilator members causes eccentric movement of the first and second axes defined by the first and second dilator members. Additional dilators members may be sequentially supported on the first and second dilator members. | 05-06-2010 |
| 20100069878 | Intracavitary Radiation System - A system is provided for use in brachytherapy where a central tube permits passage of a radioactive source therethrough to deliver a prescribed dosage of radiation. One or more balloons are coaxially positioned around the central tube. At least one balloon includes one or more peripheral tubes extending along at least a portion of the balloon. The peripheral tube is also attached to the high dose rate brachytherapy unit in order to permit passage of a radioactive source therethrough. | 03-18-2010 |
| 20100056446 | NA+K+-ATPase-Specific Peptide Inhibitors/Activators of SRC and SRC Family Kinases - A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. | 03-04-2010 |
| 20100049206 | INSERTION ASSEMBLY FOR MINIMALLY INVASIVE SPINAL SURGERY - A telescopic insertion assembly is configured to insert a pedicle screw into a vertebral body. The insertion assembly includes an attachment fixture having one end configured to mate with the pedicle screw and another end having a ridged portion. A center tube is provided having one end slidably attached to the attachment fixture and another end having an internally ridged portion. A telescoping member has one ridged end configured to slidably attach to the center tube and another end having a yoke. The telescoping member is configured to extend the yoke to different distances from the center tube. An alignment member is configured to hingeably attach to the yoke of the telescoping member. The alignment member is configured to rotate from a first position to a second position. The second position of the alignment member is above a top surface of a patient's skin. | 02-25-2010 |
| 20100004651 | TRANSPEDICULAR ACCESS TO THE INTERVERTEBRAL DISC SPACE FOR DISCECTOMY, END PLATE PREPARATION, AND INTERBODY FUSION - An insertion device is configured to access a disc positioned between adjacent vertebrae. The insertion device includes a cannula having a passage formed therein. The cannula has an exit aperture. An obturator is substantially positioned within the passage formed in the cannula. One end of the obturator has a probe and the other end of the obturator has a head. An impaction cap is in contact with the cannula and is positioned to cover the head of the obturator. The impaction cap is configured to allow at least a portion of the cannula to be inserted through a portion of one vertebra without deployment of the probe of the obturator through the exit aperture of the cannula. | 01-07-2010 |
| 20090286125 | BI-ELECTRODE SUPPORTED SOLID OXIDE FUEL CELLS HAVING GAS FLOW PLENUM CHANNELS AND METHODS OF MAKING SAME - A solid oxide fuel cell (SOFC) has a porous electrode support structure on both sides of a thin electrolyte layer. The porous electrode supported cell is formed with gas flow plenum channels on an outer surface of the electrode scaffold. | 11-19-2009 |
| 20090036772 | HIGH FRAME RATE IMAGING SYSTEM - A system for producing an image using an imaging system includes a) transmitting at least one signal of energy toward an object to be imaged by using two transmitters having the same output amplitude but of an opposite sign, or by using one transmitter to perform the task; b) exciting at least one transducer element to produce limited-diffraction array beams or their square-wave approximations with two levels of quantitations for both sine and cosine functions, c) weighting the received signals spatially with limited-diffraction array beams, their square-wave approximations, or spatial Fourier transform, and d) digitizing and then transferring received signals through high-speed optical fibers to a system for image reconstructions. | 02-05-2009 |
| 20080311569 | METHOD FOR QUANTITATIVE MEASUREMENT OF GENE EXPRESSION FOR INDENTIFYING INDIVIDUALS AT RISK FOR BRONCHOGENIC CARCINOMA - A method measure expression of multiple target genes in a progenitor cell for bronchogenic carcinoma comprising the use of reverse transcription-polymerase chain reaction (RT-PCR) to allow simultaneous expression measurement of the multiple target genes is disclosed. | 12-18-2008 |
