The University of Tennessee Research Foundation Patent applications |
Patent application number | Title | Published |
20140286971 | SINGLE NUCLEOTIDE POLYMORPHISMS (SNP) AND ASSOCIATION WITH RESISTANCE TO IMMUNE TOLERANCE INDUCTION - This application discloses methods, systems and kits for correlating the presence or absence of certain nucleic acid sequences within a population with the ability to create immune tolerance in that same population. Tolerance can be induced by solo or repeated administration of antigen, including soluble antigens administered either intravenously or sublingually. This application also discloses methods for detecting variants. In addition the application addresses the use or avoidance of non steroidal anti inflammatory drugs in therapy. | 09-25-2014 |
20140107035 | METHODS OF TREATING FIBROSING DISEASES BY INDUCTION OF IMMUNE TOLERANCE - The present invention has demonstrated for the first time that orally administered type I collagen (CI) induced tolerance to CI in patients suffering from systemic sclerosis (SSc) and ameliorated clinical manifestations of the disease. Accordingly, the present invention provides methods of treating a fibrosing disease by oral administration of a tissue protein, for example, collagen, derived from the tissue undergoing fibrosis. | 04-17-2014 |
20140094518 | METHOD FOR REGULATING RETINAL ENDOTHELIAL CELL VIABILITY - Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma. | 04-03-2014 |
20130030713 | METHODS OF ASSOCIATING AN UNKOWN BIOLOGICAL SPECIMEN WITH A FAMILY - The present invention provides a method of predicting whether an unknown biological specimen originates from a member of a particular family. The method compares DNA profiles from at least one unknown biological specimen to DNA profiles of more than one family member, which significantly increases the methods' predictive ability. In particular, the invention describes a method of comparing test DNA profiles from unknown biological specimens to a family pedigree comprising target DNA profiles obtained from biological specimens of family members. In one embodiment, a modified Elston Stewart algorithm is used to determine a probability that a genetic relationship exists between at least one unknown biological specimen and the family pedigree. | 01-31-2013 |
20120329879 | BETA-ADRENERGIC RECEPTOR AGONISTS AND USES THEREOF - Provided herein are methods for improving function in a retinal cell associated with a diabetic condition and for treating a diabetic retinopathic condition in a subject. The methods comprise contacting the retinal cell or administering to the subject a beta-adrenergic receptor agonist or R-isomer thereof such as have the chemical structural formula: | 12-27-2012 |
20120135014 | SINGLE NUCLEOTIDE POLYMORPHISMS (SNP) AND ASSOCIATION WITH RESISTANCE TO IMMUNE TOLERANCE INDUCTION - This application discloses methods, systems and kits for correlating the presence or absence of certain nucleic acid sequences within a population with the ability to create immune tolerance in that same population. Tolerance can be induced by solo or repeated administration of antigen, including soluble antigens administered either intravenously or sublingually. This application also discloses methods for detecting variants. In addition the application addresses the use or avoidance of non steroidal anti inflammatory drugs in therapy. | 05-31-2012 |
20120116195 | METHOD AND DEVICE FOR DETECTION OF BIOAVAILABLE DRUG CONCENTRATION IN A FLUID SAMPLE - The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration. | 05-10-2012 |
20110295518 | METHODS OF ASSOCIATING AN UNKNOWN BIOLOGICAL SPECIMEN WITH A FAMILY - The present invention provides at least three methods of predicting whether an unknown biological specimen originates from a member of a particular family. These methods compare DNA profiles from unknown biological specimens to DNA profiles of more than one family member, which significantly increases the methods' identification ability. In particular, the invention describes combining at least a ranked first family member list and a ranked second family member list to create a combined ranked list and identifying the unknown biological specimen as one contained among a list of specimens having the highest combined rankings representing the candidates that are most likely related to the family. A second method encompasses comparing test DNA profiles from unknown biological specimens to a family pedigree comprising target DNA profiles obtained from multiple biological specimens of family members. This method also embodies using a modified Elston Stewart algorithm to determine a pedigree likelihood ratio to rank and identify the test profile of the unknown biological specimen most likely to be the missing person sought after by the corresponding family represented by the family pedigree. A third method encompasses construction of a database or directed graph of discovered or known relationships between biological specimens and comparison to a graph representing a family pedigree to identify portions of the database or directed graph that correspond to portions of the family pedigree, in order to rank or identify one or more unknown biological specimens as most likely related to one or more family pedigrees. | 12-01-2011 |
20100179096 | METHODS OF TREATING FIBROSING DISEASES BY INDUCTION OF IMMUNE TOLERANCE - The present invention has demonstrated for the first time that orally administered type I collagen (CI) induced tolerance to CI in patients suffering from systemic sclerosis (SSc) and ameliorated clinical manifestations of the disease. Accordingly, the present invention provides methods of treating a fibrosing disease by oral administration of a tissue protein, for example, collagen, derived from the tissue undergoing fibrosis. | 07-15-2010 |
20090150318 | Method of Enhancing Expert System Decision Making - Methods of analyzing data are provided. An expert system receives input from at least a first source. Data is imported and analyzed by an expert system, wherein the expert system makes at least one first decision, which characterizes the data based on a rule base. The at least one first decision is displayable and modifiable by a first input from a first source. In response to the first input from the first source, the rule base may be re-applied to make at least one second decision, wherein the at least one second decision is different from the at least one first decision, or the at least one first decision may be accepted. The at least one first decision or the at least one second decision is then displayable and modifiable in response to a first input from a second source. In response to the first input from the second source, the rule base is either re-applied to make at least one third decision, wherein the third decision is different from the second decision, or either the first or second decisions are accepted. | 06-11-2009 |
20080288428 | Method of Interaction With an Automated System - Methods of analyzing data are provided. An expert system receives input from at least a first source. Data is imported and analyzed by an expert system, wherein the expert system makes at least one first decision, which characterizes the data based on a rule base. The at least one first decision is displayable and modifiable by a first input from a first source. In response to the first input from the first source, the rule base may be re-applied to make at least one second decision, wherein the at least one second decision is different from the at least one first decision, or the at least one first decision may be accepted. The at least one first decision or the at least one second decision is then displayable and modifiable in response to a first input from a second source. In response to the first input from the second source, the rule base is either re-applied to make at least one third decision, wherein the third decision is different from the second decision, or either the first or second decisions are accepted. | 11-20-2008 |
20080276162 | Method of Organizing and Presenting Data in a Table - An item is organized and presented by displaying a table, wherein the table displays a plurality of data comprising analysis results characterizing the at least one item, and wherein an analysis result is based on a decision made by an expert system according to a rule base. Input is accepted from a source, wherein the input may cause the analysis results to be modified, and wherein the results may be modified by re-applying the rule base. In response to the input, an updated table is created, wherein the updated table comprises the modified analysis results. This updated table is then displayable. | 11-06-2008 |