| THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA Patent applications |
| Patent application number | Title | Published |
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| 20120136180 | Imprinted Biomimetic Catalysts for Cellulose Hydrolysis - The present disclosure describes methods and biomimetic catalysts useful for hydrolyzing glucose polymers, such as cellulose, and oligomers, such as cellobiose, to glucose for the subsequent production of ethanol. | 05-31-2012 |
| 20120135884 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING MACULAR DEGENERATION - The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications. | 05-31-2012 |
| 20120129810 | COMBINATION ANTINEOPLASTIC THERAPY - The present invention is directed to methods of using a sirolimus drug and chloroquine or a quinoline derivative in combination. Methods of use are also described. | 05-24-2012 |
| 20120129273 | PHOTOLITHOGRAPHICALLY DEFINED CONTACTS TO CARBON NANOSTRUCTURES - Methods for the fabrication of nanostructures, including nanostructures comprised of carbon nanotubes, and the nanostructures, devices, and assemblies prepared by these methods, are described. | 05-24-2012 |
| 20120122910 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR - Disclosed herein are methods of treating cancer by administering to a patient a small molecule inhibitor of Survivin. Also disclosed herein are methods of inhibiting Survivin dimerization in a patient by administering a compound of formula (I), (II), (III), or (IV). Methods of inducing cell cycle arrest in cancer cells, comprising G2/M stage arrest, in a patient by administering a compound of formula (I), (II), (III), or (IV) are also disclosed. Further disclosed herein are methods of inducing apoptosis in cancer cells in a patient by administering a compound of formula (I), (II), (III), or (IV). | 05-17-2012 |
| 20120116221 | METHODS AND SYSTEMS FOR IMAGE-GUIDED TREATMENT OF BLOOD VESSELS - Methods and systems of treating at least one blood vessel involves the application of therapy ultrasound to the blood vessel(s) using one or more dosing conditions. An image of the region of interest is acquired responsive to the applied therapy ultrasound. A change in vascularity of the blood vessel(s) is estimated, responsive to the applied therapy ultrasound, using the acquired image to determine whether to adjust at least one of the dosing conditions. The therapy ultrasound is applied with an intensity to modify the blood vessel(s) without damaging a surrounding tissue. A method of treating a tumor comprises introducing a therapeutic agent into a bloodstream and applying therapy ultrasound to blood vessel(s). The therapy ultrasound, along with an agent, disrupts the blood vessel(s) to limit flow to and from the tumor, thereby retaining the therapeutic agent within the tumor. | 05-10-2012 |
| 20120114676 | METHODS OF TREATING CANCER WITH PHENFORMIN - Methods of using phenformin to treat certain types of cancers are described. | 05-10-2012 |
| 20120114615 | HYDROLYTICALLY DEGRADABLE POLYSACCHARIDE HYDROGELS - Provided are polysaccharide compositions capable of controllable hydrolytic degradation and suitable for controlled release of therapeutic agents. Also provided are methods for synthesizing such compositions and a variety of applications in which the compositions may be used. | 05-10-2012 |
| 20120108559 | RECEPTOR ACTIVATOR OF THE RANK RECEPTOR COMPLEX INHIBITOR - Methods and pharmaceutical compositions utilizing compounds of Formula II: for inhibiting osteoclastogenesis and the activity of osteoclasts in patients. | 05-03-2012 |
| 20120107593 | HIGH YIELD PREPARATION OF MACROSCOPIC GRAPHENE OXIDE MEMBRANES - Disclosed are graphene oxide membrane materials of high surface area, which membranes suitably have a surface area of above about 200 μm and exhibit electrical conductivity in excess of about 200 S/m. Also provided are methods of synthesizing such membranes, as well as devices and sensors that incorporate these novel grapheme materials. | 05-03-2012 |
| 20120093913 | Inhibition of SYK kinase expression - The present invention relates, in general, to Syk kinase and, in particular, to a method of inhibiting Syk kinase expression using small interfering RNA (siRNA). | 04-19-2012 |
| 20120093853 | Simian Adenovirus Vectors and Methods of Use - A recombinant vector comprises a simian adenovirus capsid and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 04-19-2012 |
| 20120093778 | SIMIAN ADENOVIRUS NUCLEIC ACID AND AMINO ACID SEQUENCES, VECTORS CONTAINING SAME, AND METHODS OF USE - A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 04-19-2012 |
| 20120093717 | MICROSPHERE/NANOFIBER COMPOSITES FOR DELIVERY OF DRUGS, GROWTH FACTORS, AND OTHER AGENTS - Provided are compositions that include polymeric fibers and microspheres entrapped within the fibers, the compositions being capable of controlled delivery of one or more agents while also maintaining their structural properties. Also provided are related methods of fabricating these compositions and methods of utilizing the compositions to deliver agents to a subject. | 04-19-2012 |
| 20120075703 | OPTICAL DEVICE USING LATERALLY-SHIFTABLE DIFFRACTION GRATINGS - A double-sided grating divider acts as a light switch where the upper and lower grating dividers are arranged to accommodate a relative lateral shift therebetween of about one-fourth of the period of the diffraction grating elements and where the critical refraction angles of the grating dividers are more than about 43.6°. Lateral shift may be achieved by various devices including MEMS and metal couplers having a known/calibrated thermal coefficient of expansion over a temperature range of interest. | 03-29-2012 |
| 20120058102 | PHARMACOLOGICALLY INDUCED TRANSGENE ABLATION SYSTEM - The present invention relates to gene therapy systems designed for the delivery of a therapeutic product to a subject using replication-defective virus composition(s) engineered with a built-in safety mechanism for ablating the therapeutic gene product, either permanently or temporarily, in response to a pharmacological agent—preferably an oral formulation, e.g., a pill. The invention is based, in part, on the applicants' development of an integrated approach, referred to herein as “PITA” (Pharmacologically Induced Transgene Ablation), for ablating a transgene or negatively regulating transgene expression. In this approach, replication-deficient viruses are used to deliver a transgene encoding a therapeutic product (an RNA or a protein) so that it is expressed in the subject, but can be reversibly or irreversibly turned off by administering the pharmacological agent; e.g., by administration of a small molecule that induces expression of an ablator specific for the transgene or its RNA transcript. | 03-08-2012 |
| 20120046349 | COMPOSITIONS FOR TARGETING CONDUCTING AIRWAY CELLS COMPRISING ADENO-ASSOCIATED VIRUS CONSTRUCTS - An artificial AAV capsid comprising a heterologous conducting airway targeting sequence is provided. The artificial AAV is useful as a targeting moiety, for delivery of heterologous molecules which are associated therewith. The artificial AAV is also useful in the generation of AAV vectors having the artificial capsid. Also described are methods of modifying the native tropism and transduction efficiency of vectors by improving and/or ablating their ability to transduce conducting airway cells. Methods of targeting conducting airway cells and delivering therapeutic and other molecules thereto are also provided. | 02-23-2012 |
| 20120039986 | COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOPOIETIN 1 AND 2 AND THEIR RECEPTOR TIE2 - RNA interference using small interfering RNAs which are specific for mRNA produced from the Ang1, Ang2 or Tie2 genes inhibits expression of these genes. Diseases which involve Ang1, Ang2 or Tie2 mediated angiogenesis, such as inflammatory and autoimmune diseases, diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs. | 02-16-2012 |
| 20120026180 | SYSTEMS AND METHODS FOR CAPTURING AND RECREATING THE FEEL OF SURFACES - Systems and methods for capturing and recreating the feel of a surface are disclosed. A method for capturing a feel of a surface comprises contacting the surface with a handheld tool, recording data measured by the tool, and generating a texture model of the surface based on the recorded data. A method for recreating a feel of a surface comprises contacting a virtual surface with a handheld tool, determining an estimated contact force based on the data measured by the tool, generating a vibration waveform from a texture model based on the data measured by the tool; and actuating at least one actuator of the tool according to the vibration waveform. A system for capturing and recreating a feel of a surface comprises a handheld tool, a storage device, and a processor. | 02-02-2012 |
| 20120019245 | CEST MRI METHODS FOR IMAGING OF METABOLITES AND THE USE OF SAME AS BIOMARKERS - The CEST effect for various neurotransmitters and energy metabolites in the brain and muscles and various endogenous metabolites in the liver, brain, and myocardium are imaged using MR imaging to illustrate a unique CEST effect that may be used to monitor the concentration of the metabolite and hence to characterize and monitor various disease states in the body correlated to the concentration of that metabolite. By adjusting the timing, amplitude, and length of the RF pulse as well as other parameters of the CEST pulse sequence to address the unique chemical shifts and exchange rates of the target, new targets with unique characteristics may be acquired using CEST MR imaging. | 01-26-2012 |
| 20120016442 | REGULATION OF GENES VIA APPLICATION OF SPECIFIC AND SELECTIVE ELECTRICAL AND ELECTROMAGNETIC SIGNALS - Methods and devices for the regulation of gene expression by cells via the application of fields generated by specific and selective electric and electromagnetic signals so as to target diseased or injured tissue for treatment. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased tissue that include providing specific and selective electric and electromagnetic signals and exposing tissue to the fields generated by the signals so as to regulate gene expression. In particular, methods and devices are provided for the targeted treatment of bone defects, osteoarthritis, osteoporosis, cancer, and other disease states. | 01-19-2012 |
| 20120003212 | ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS - The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention. | 01-05-2012 |
| 20110306065 | USE OF AN ANTIBODY AND A RARE-EARTH BASED CRYSTAL - The present invention provides compositions and methods for the detection of red blood cells antigens. The methods and compositions are based on antibodies, serving as primary antibodies or secondary antibodies, that are labeled with a rare-earth based crystal. Methods utilizing antibodies labeled with a rare-earth based crystal enhance the efficiency and accuracy of blood compatability tests and red blood cells phenotyping. | 12-15-2011 |
| 20110301153 | METHODS OF TREATING CANCER - The invention concerns methods of treating cancer comprising contacting said tumors with a chemical inhibitor of glutaminolysis. These inhibitors include amino-oxyacetate, phenylbutyrate, phenylacetate, and 3,7-bis(dimethylamino)-phenazathionium chloride (methylene blue). | 12-08-2011 |
| 20110301075 | Use of BBI/BBIC for Treatment of Muscular Atrophy and Degenerative Muscle Disease - Methods for use of a composition comprising Bowman-Birk Inhibitor (BBI) or a derivative thereof in the treatment and/or prevention of skeletal muscle atrophy, to improve of skeletal muscle function, and to alleviate symptoms and/or slow progression of degenerative skeletal muscle diseases or disorders are provided. | 12-08-2011 |
| 20110294785 | INFLUENZA A VIRUS INHIBITION - Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein. | 12-01-2011 |
| 20110288418 | IN VIVO MEASUREMENT OF MITOCHONDRIAL FUNCTION - Disclosed herein are devices for assessing mitochondrial function in a living subject comprising a catheter comprising a sheath defining a lumen, a distal end, and a proximal end comprising a light guide for radiating light onto a target within the subject and for receiving a fluorescence signal from the target; a light source, wherein the catheter is adapted for transmitting light from the light source to the light guide; and, a detector for receiving the fluorescence signal from the light guide and for correlating the fluorescence signal to the mitochondrial function of the target. Also disclosed are methods for assessing mitochondrial function in a living subject comprising placing a catheter proximate to a site of interest within the subject; using the catheter to acquire fluorescence signals from cells at the site of interest; and, correlating the fluorescence signals to the mitochondrial function of the cells. | 11-24-2011 |
| 20110288151 | METHODS OF CHARACTERIZING BREAST CANCER AND IDENTIFYING TREATMENTS FOR SAME - This application describes antibodies to P-Rex 1, and methods of detecting breast cancer, and methods of treatments for the same. | 11-24-2011 |
| 20110288111 | INHIBITION OF INFLUENZA M2 PROTON CHANNEL - Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein. | 11-24-2011 |
| 20110269208 | CROSS-LINKED POLYMER NETWORK FORMED BY SEQUENTIAL CROSS-LINKING - The convention concerns methods for preparing a cross-linked polymer network comprising: forming a plurality of cross-links in a polymer network by (i) addition polymerization or (ii) ionic polymerization or (iii) partial radical polymerization of the polymer network to produce an intermediate polymer network, and forming further cross-links in the polymer network by radical polymerization of the intermediate polymer network to produce the cross-linked polymer network. | 11-03-2011 |
| 20110268752 | Inducible Regulatory T-Cell Generation for Hematopoietic Transplants - The present invention provides methods and compositions for converting non-Tregs into Tregs. The converted Tregs are referred to as inducible Tregs (iTregs). The iTregs are useful for preventing, suppressing, blocking or inhibiting an immune response. For example the iTregs are useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft vs host disease. The iTregs can also be used to treat autoimmune diseases. | 11-03-2011 |
| 20110266512 | NON-VOLATILE RESISTANCE-SWITCHING THIN FILM DEVICES - Disclosed herein is a resistive switching device having an amorphous layer comprised of an insulating silicon-containing material and a conducting material. The amorphous layer may be disposed between two or more electrodes and be capable of switching between at least two resistance states. Circuits and memory devices including resistive switching devices are also disclosed, and a composition of matter involving an insulating silicon-containing material and a conducting material comprising between 5 and 40 percent by molar percentage of the composition is disclosed herein as well. Also disclosed herein are methods for switching the resistance of an amorphous material. | 11-03-2011 |
| 20110263027 | Adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby - Adeno-associated virus 7 sequences, vectors containing same, and methods of use are provided. | 10-27-2011 |
| 20110262899 | FLUORESCENT LABELING OF TRANSFER RNA AND STUDY OF PROTEIN SYNTHESIS - Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system. The disclosed methods are useful in single molecule as well as in ensemble settings. | 10-27-2011 |
| 20110262466 | COMPOSITIONS CONTAINING THROMBOMODULIN DOMAINS AND USES THEREOF - Compositions are provided comprising a thrombomodulin domain linked to a targeting moiety that binds to a determinant on the surface of a target endothelial cell or red blood cell, wherein the thrombomodulin domain may be the extracellular domain, the N-terminal lectin-like domain, or an epidermal growth factor (EGF)-like domain. The targeting moiety may be a single chain antigen-binding domain (scFv), and the targeting moiety and thrombomodulin domain of the composition may be linked as a continuous polypeptide chain. Methods of delivery and use of a composition described herein are provided, as well as methods of treating or preventing thrombosis, inflammation, tissue ischemia, sepsis, acute lung injury (ALI), acute myocardial infarction (AMI), ischemic stroke, cerebrovascular disease, pulmonary embolism, or ischemic peripheral vascular disease is provided. | 10-27-2011 |
| 20110257356 | Synthesis of Poly-(P-Aryleneethynylene)s in Neat Water Under Aerobic Conditions - Provided are ethyne synthons comprising boron and related methods. Also provided are related water-soluble arylethynylene polymers capable of being synthesized in neat water under aerobic conditions. | 10-20-2011 |
| 20110251510 | RESPIRATION SENSOR FOR AN INFANT FEEDING PERFORMANCE MEASUREMENT DEVICE - Devices, systems and methods for measuring infant feeding performance. The device includes a body portion, a respiration sensing device for receiving respiration and an integrated circuit disposed in the body portion and electrically connected to the respiration sensing device. The body portion has a first end for receiving a fluid, a second end for passing fluid to a feeding nipple, and a conduit in fluid communication with the first end and the second end. The respiration sensing device is mechanically coupled to the body portion and is mateable with the feeding nipple. The respiration sensing device generates a signal representing a variation in temperature or airflow of the respiration during a feeding session. The integrated circuit receives the temperature or airflow signal determines a respiration pattern over the feeding session indicative of the infant feeding performance. | 10-13-2011 |
| 20110244116 | SELECTIVE NANOPARTICLE ASSEMBLY SYSTEMS AND METHODS - Disclosed are methods and systems for transferring dry or semi-dry nanoparticles onto a substrate. In one embodiment, this includes the steps of providing a roller comprising an elastomeric stamp; transferring nanoparticles in a dry or semi-dry state, and which contact the surface of a donor substrate, from the donor substrate onto the elastomeric stamp; and depositing the dry or semi-dry nanoparticles from the elastomeric stamp onto a receiver substrate by rolling the elastomeric stamp onto the receiver substrate. The substrate, in other embodiments, can have a relief structure. | 10-06-2011 |
| 20110236353 | ADENO-ASSOCIATED VIRUS (AAV) CLADES, SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR - Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided. | 09-29-2011 |
| 20110223135 | SIMIAN ADENOVIRUSES SAdV-43, -45, -46, -47, -48, -49, AND -50 AND USES THEREOF - A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 09-15-2011 |
| 20110207957 | PROCESSES FOR THE PREPARATION OF BIPHENYL COMPOUNDS - The invention concerns processes for the synthesis of a compound of the formula: wherein: R | 08-25-2011 |
| 20110205617 | REFLECTION-MINIMIZED PHOTONIC CRYSTAL AND DEVICE UTILIZING SAME - A photonic crystal structure that is composed of a host media having periodic dielectric holes disposed in the media at a period of a | 08-25-2011 |
| 20110195053 | Treatment of Non-Neuronal Cancer using HSV-1 Variants - A mutant herpes simplex virus which has been modified in the γ34.5 gene such that the gene is non-functional is used to treat a non-neuronal cancer such as a mesothelioma, ovarian carcinoma, bladder cancer or melanoma. Typically, the mutant herpes simplex virus has been modified within the BamHI restriction fragment of the long terminal repeat of the viral genome. | 08-11-2011 |
| 20110190400 | Novel Compounds for Treatment of Malignant Tumors - The present invention comprises compounds, compositions and methods of use for sensitizing cancer cells, tumors, neoplasms, and malignancies to the effects of ionizing radiation used in the treatment of cancer. The invention further comprises a method of identifying novel radiosensitizing compounds. | 08-04-2011 |
| 20110181956 | OPTICAL DEVICE USING DIFFRACTION GRATINGS - A double-sided grating divider acts as a light switch where the upper and lower grating dividers are arranged to accommodate a relative lateral shift therebetween of about one-fourth of the period of the diffraction grating elements and where the critical refraction angles of the grating dividers are more than about 43.6°. Lateral shift may be achieved by various devices including MEMS and metal couplers having a known/calibrated thermal coefficient of expansion over a temperature range of interest. | 07-28-2011 |
| 20110181150 | PIEZOELECTRIC ALN RF MEM SWITCHES MONOLITHICALLY INTEGRATED WITH ALN CONTOUR-MODE RESONATORS - Piezoelectric switches and methods of forming piezoelectric switches. The piezoelectric switch includes first and second cantilever beam actuators. The second cantilever beam actuator has a projection that overlaps the first cantilever beam actuator in a contact region. The projection is mechanically separated from the first cantilever beam actuator by a nanogap such that the first and second cantilever beam actuators are electrically isolated from each other. Each of the first and second cantilever beam actuators includes a piezoelectric actuation layer. | 07-28-2011 |
| 20110177967 | METHODS AND COMPOSITIONS USING SPLICING REGULATORY PROTEINS INVOLVED IN TUMOR SUPPRESSION - Methods and compositions for diagnosis and prognosis of mammalian carcinoma or cancer derived from primary epithelial cells and tissue fibrosis are designed using newly identified epithelial cell-type specific splicing factors ESRP1 and ESRP2, which have roles in tumor suppression. Diagnostic reagents for the detection of these splicing factors in nucleotide or protein form are useful in such methods. Therapeutic compositions can provide epithelial cells with these factors to maintain FGFR2 and assist in suppressing metastasis. A high throughput splicing assay to identify compounds that change splicing events is described. RNCP1 is also identified as a splicing factor and a diagnostic for conditions characterized by inappropriate FGFR2-splicing. | 07-21-2011 |
| 20110172704 | SOLDER FORMULATION AND USE IN TISSUE WELDING - Supersaturated gel formulations including a solution of chitosan, albumin, and a laser specific chromophore. Laser tissue welding methods using the gel formulations of the present invention are also described. In the methods, the gel formulation of the present invention is provided to a site for tissue repair and the laser specific chromophore within the gel is excited with a laser in order to fuse tissue by inducing protein denaturation. The gel formulations and laser tissue welding methods may be used, for example, to enable skull base repairs, aerodigestive endoscopic repairs, endoscopic endonasal surgical repairs, iatrogenic esophageal perforation repairs, laparoscopic abdominal surgical repairs, lung repairs, colon repairs, anastomosis of vessels, urologic/gynecologic endoscopic pelvic repairs, orofacial surgical repairs, dental replacement, skin closure, uterine closure and repairs after fibroidectomies and bladder surgery. | 07-14-2011 |
| 20110172308 | Antagonsim of PGF2a Receptor to Treat Hyertension Characterized by Activation of the Renin-Angiotensin-Aldosterone System - The present invention relates to methods for identifying candidate therapeutics for hypertension. The invention further provides a method for treating hypertension and/or decreasing atherogenesis by administration of an inhibitor of PGF | 07-14-2011 |
| 20110172220 | DISCODERMOLIDE ANALOGUES AND METHODS OF THEIR USE - 6- and 7-substituted coumarin and related 6- and 7-substituted 1H-quinolin-2-one compounds, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the 7-substituted coumarin and related 7-substituted 1H-quinolin-2-one compounds mimic or exceed the high level of pharmacological activity of discodermolide. In other embodiments, their preparation involves more readily available materials, higher yield processes and/or simpler synthetic sequences. In yet other embodiments, the compounds of the invention represent structurally simpler, therapeutically active analogues of discodermolide than heretofore known and may be useful as microtubule stabilizers and, inter alia, for treating and/or preventing cancer and other diseases, disorders, and/or conditions mediated by the stabilization of microtubules. | 07-14-2011 |
| 20110152116 | NANOASSAYS - The present invention provides assays of nanometer-level dimension. | 06-23-2011 |
| 20110151434 | ADENO-ASSOCIATED VIRUS (AAV) SEQUENCES AND ISOLATING NOVEL SEQUENCES IDENTIFIED THEREBY - A method for detecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided, which sample contains DNA and proviral AAV. The method involves subjecting the sample containing DNA to amplification via polymerase chain reaction (PCR) using a first set of primers which specifically amplify a first AAV region. The first AAV region is characterized by having at least 250 nucleotides of AAV capsid nucleic acid sequence, a variable sequence flanked by a sequence of at least 18 nucleotides at the 5′ end of the first AAV region and a sequence of at least 18 nucleotides at the 3′ end of the first AAV region. Each of the 5′ and 3′ at least 18 nucleotides is the same over at least 9 consecutive nucleotides relative to corresponding sequences in an alignment of at least two AAV serotypes. Each of the sets of primers consist of a 5′ primer and a 3′ primer. The method is further useful for identifying AAV sequences in the sample by the presence of amplified proviral AAV sequences. | 06-23-2011 |
| 20110148251 | SYSTEMS AND METHODS FOR OPERATING PIEZOELECTRIC SWITCHES - Systems and methods for operating piezoelectric switches are disclosed. A piezoelectric switching system includes a first actuator, a second actuator, and a bias voltage source. The first actuator has a first body electrode, a first gate electrode, and a first contact region. The second actuator has a second body electrode, a second gate electrode, and a second contact region. The first and second contact regions are separated by a gap. The bias voltage source applies a bias voltage to the body electrodes. The bias voltage is lower in magnitude than an actuation voltage for the switch. The gate electrodes receive a switching voltage. The switching voltage causes at least one of the first and second actuators to bend, thereby closing the gap such that the second contact region electrically contacts the first contact region. The difference between the switching voltage and the bias voltage exceeds the actuation voltage of the switch. | 06-23-2011 |
| 20110142789 | Compositions and Methods for the Diagnosis and Treatment of Amyotrophic Lateral Sclerosis - Compositions and methods for diagnosis and treatment of ALS are provided. | 06-16-2011 |
| 20110125050 | Multiple-Electrode and Metal-Coated Probes - Provided are probes featuring multiple electrodes, which probes have diameters in the nanometer range and may be inserted into cells or other subjects so as to monitor an electrical characteristic of the subject. The probes may also include a conductive coating on at least one probe element to improve the probes' performance. The probes may also be used to inject a fluid or other agent into the subject and simultaneously monitor changes in the subject's electrical characteristics in response to the injection. Related methods of fabricating and of using the inventive probes are also provided. | 05-26-2011 |
| 20110124560 | FOXP3 OLIGOMERIZATION AND INTERMOLECULAR INTERACTIONS - Methods of identifying immune response modulators are disclosed. Some methods comprise identifying chemical candidates that modulate oligomerization of FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate the hetero-oligomerization of FOXP1 with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate interaction of IL-2 promoter with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Method of treating individuals who have or are suspected of having autoimmune disease, inflammatory disease, cell, tissue or organ transplantation, or coronary artery disease, and methods of treating individuals who have or are suspected of having infectious disease, cancer, or who are immunocompromised or undergoing vaccination are disclosed. | 05-26-2011 |
| 20110117020 | IMAGING DENDRIMER NANOPROBES AND USES THEREOF - This invention relates to imaging nanoprobe and methods of use thereof. Specifically, the invention relates to long-lived oxygen-insensitive nanoprobe comprising a lumisescent moeity with a long excited state lifetime, embedded in a dendrimer, wherein said dendrimer is internally cross-linked and has hydrophilic peripheral layer. | 05-19-2011 |
| 20110112510 | METHODS, COMPOSITIONS AND APPARATUS FOR DELIVERING HETEROLOGOUS MOLECULES TO CELLS - A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex. | 05-12-2011 |
| 20110110924 | Resistin as a Marker and Therapeutic Target for Cardiovascular Disease - The risk or progression of cardiovascular disease and coronary artery disease is assessed in a mammalian subject by measuring the level or concentration of circulating serum resistin in a subject and comparing the measured level to resistin levels within a standardized or standard population. Methods of treating cardiovascular diseases and/or inflammatory disorders involve administering to a patient a composition that can reduce the circulating levels of resistin. | 05-12-2011 |
| 20110105869 | Sensor for Internal Monitoring of Tissue O2 and/or pH/CO2 In Vivo - Provided is a durable tissue pH/pCO | 05-05-2011 |
| 20110105841 | MEDICAL INSTRUMENT SYSTEM AND METHOD FOR MANIPULATING TARGET TISSUE - A method is provided for manipulating target tissue of a patient during a medical procedure. The method includes introducing a medical instrument system to a general site of target tissue. At least one characteristic of the target tissue is identified using an imaging device located in a working channel of the medical instrument system. The imaging device is removed from the working channel of the medical instrument system, and a medical instrument is inserted through the working channel of the medical instrument system. The target tissue is then manipulated using the medical instrument. A medical instrument system is also provided for manipulating target tissue of a patient during a medical procedure. | 05-05-2011 |
| 20110098826 | Disc-Like Angle-Ply Structures for Intervertebral Disc Tissue Engineering and Replacement - Provided are implant scaffolds comprising angle-ply arrays of two or more layers of substantially aligned fiber, methods of making and using said scaffolds, and kits comprising such scaffolds. | 04-28-2011 |
| 20110097719 | Neprilysin Gene Polymorphism and Amyloid Beta Plaques in Traumatic Brain Injury - The invention relates to methods of diagnosing risk of amyloid β deposition following traumatic brain injury. More particularly, the invention relates to the discovery of a specific single nucleotide polymorphism in the neprilysin gene that is linked to an increased risk of amyloid β deposition after traumatic brain injury | 04-28-2011 |
| 20110092571 | COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ICAM-1 - RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory and autoimmune diseases, diabetic retinopathy and other complications arising from type I diabetes, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs. | 04-21-2011 |
| 20110088413 | SYSTEM AND METHOD FOR PRODUCING AND DETERMINING COOLING CAPACITY OF TWO-PHASE COOLANTS - The invention provides systems and devices for producing two-phase coolants such as an ice slurry. Also provided are methods for producing two-phase coolants, and methods for using the two-phase coolants to lower the temperature or maintain a low temperature in any subject, system, object, device, or application where particular low temperatures are desired. Also provided are systems for determining the cooling capacity of two-phase coolants. | 04-21-2011 |
| 20110086904 | GENERATION OF HYPERSTABLE mRNAs - Provided herein is a method for enhancing the stability of a mRNA molecule. Specifically, the invention provides methods of increasing stability or augmenting expression of mRNA or its products by inserting a stability inducing motif at the 3′UTR of the molecule. | 04-14-2011 |
| 20110086028 | PREVENTION OF HIV INFECTION - This invention relates to methods compositions and devices for inhibiting infection of a subject's host cell by HIV. Specifically, the invention relates to methods and compositions capable of inhibiting the binding and subsequent infection by HIV of a host cell through the inhibition of the interaction between gp-340 expressed on the cell surface and V3 loop on the HIV envelope and devices comprising these compositions. | 04-14-2011 |
| 20110059065 | FUNCTION AND REGULATION OF ADAMTS-1 - The present invention relates to ADAMTS-1 and uses thereof. The present invention also relates to fragments of ADAMTS-1 and methods of inhibiting cell growth and metastasis. The present invention also provide methods of identifying inhibitors and activators relating to the function of ADAMTS-1. | 03-10-2011 |
| 20110052547 | RAPAMYCIN-RESISTANT T CELLS AND THERAPEUTIC USES THEREOF - Methods for generating highly enriched Th1/Tc1 and Th2/Tc2 functions are described. In particular, the generation of these functions are attained by the addition of an immune suppression drug, rapamycin or a rapamycin derivative compound. In addition to enhanced purity of T cell function, the T cells generated in rapamycin also express molecules that improve immune T cell function such as CD28 and CD62L. Such rapamycin generated functional T cell subsets may have application in the prevention or treatment of GVHD after allogeneic hematopoietic stem cell transplantation, the treatment of autoimmunity, or the therapy of infection or cancer. | 03-03-2011 |
| 20110044983 | COMPLEMENT INHIBITORS AS THERAPEUTIC AGENTS FOR TREATMENT OF CANCER - Methods for treating, preventing or delaying onset of tumor formation and other forms of cancer are disclosed. The methods involve administration of a complement inhibitor to inhibit C5a receptor signaling in the tumor microenvironment. | 02-24-2011 |
| 20110040307 | SURGICAL DEVICE FOR CONJUCTIVAL TISSUE CLOSURE - Disclosed herein is a surgical device for closing an opening in conjunctival tissue, an instrument for applying the surgical device to close an opening in conjunctival tissue, a system for closing an opening in conjunctival tissue including the surgical device and the instrument, and a method of operating the instrument and the surgical device to close an opening in conjunctival tissue. | 02-17-2011 |
| 20110033672 | PATTERNING STRUCTURES USING DEFORMABLE SUBSTRATES - Aspects of the present invention describe soft imprint lithography methods capable of preparing structural features on surfaces. Disclosed methods include surmounting a deformable substrate, having an original form, with a composition, wherein the deformable substrate is capable of achieving at least one predetermined deformed state; predictably deforming said deformable substrate from its original form to the at least one predetermined deformed state; and transferring at least a portion of the composition surmounting the deformed substrate to a receiving substrate. | 02-10-2011 |
| 20110027911 | SOLUBILIZATION AND STUDY OF MEMBRANE PROTEINS - Provided are methods for solubilizing a membrane protein in order to provide substantially homogeneous membrane proteins that are solubilized within reverse micelle systems at concentrations that are suitable for analytical study of such membrane proteins, including nuclear magnetic resonance spectroscopy. Also provided are substantially homogeneous membrane proteins that are solubilized within a reverse micelle system, as well as methods for the study of solubilized membrane proteins, and for the screening of drug candidates that target such membrane proteins. | 02-03-2011 |
| 20110014716 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING MACULAR DEGENERATION - The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications. | 01-20-2011 |
| 20110014190 | USE OF B LYMPHOCYTE STIMULATOR PROTEIN ANTAGONISTS TO PROMOTE TRANSPLANTATION TOLERANCE - The invention relates to methods of preventing, treating, ameliorating and otherwise inhibiting organ or transplant rejection in a patient by administering B Lymphocyte Stimulator antagonists. In addition, therapeutic treatment regimens are provided to promote transplant tolerance in a patient following the administration of B Lymphocyte Stimulatorantagonists. | 01-20-2011 |
| 20110008295 | SIMIAN ADENOVIRUSES SADV-36, -42.1, -42.2, AND -44 AND USES THEREOF - A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided. | 01-13-2011 |
| 20110002844 | STABILIZATION OF MACROMOLECULAR MEMBRANES - Disclosed are stabilized polymersomes having layer structures. Such stabilized polymersomes are, in some embodiments, biocompatible, and are capable of enhanced, sustained release of agents. Also disclosed are related methods for synthesizing such stabilized polymersomes and methods for using such polymersomes for delivery of therapeutic, imaging, and various other agents. | 01-06-2011 |
| 20100331523 | Heterologous Protein Production Using The Twin Arginine Translocation Pathway - Provided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in | 12-30-2010 |
| 20100331493 | LIVING RADICAL POLYPMERIZATION OF ACTIVATED AND NONACTIVATED MONOMERS CONTAINING ELECTRON-WITHDRAWING SIDE GROUPS - The invention concerns a method of polymerizing an alkene monomer to produce a polymer using a catalyst that is Cu(O), Cu | 12-30-2010 |
| 20100329529 | COMPUTER ASSISTED DIAGNOSIS (CAD) OF CANCER USING MULTI-FUNCTIONAL, MULTI-MODAL IN-VIVO MAGNETIC RESONANCE SPECTROSCOPY (MRS) AND IMAGING (MRI) - This invention relates to computer-assisted diagnostics and classification of prostate cancer. Specifically, the invention relates to segmentation of the prostate boundary on MRI images, cancer detection using multimodal multi-protocol MR data; and their integration for a computer-aided diagnosis and classification system for prostate cancer. | 12-30-2010 |
| 20100316571 | Method and Compositions for Polymer Nanocarriers Containing Therapeutic Molecules - A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The primary emulsion is formed using a freeze-thaw cycle of the amphiphilic diblock copolymer and a protein having a molecular weight of up to or equal to 300,000 Da. Selection of the hydrophobic polymer block percentage alters one or more characteristics of the resulting nanoparticles, such as shape. Thus, as one aspect, a method of producing filamentous polymeric nanocarrier-encapsulated protein (i.e., active enzyme) particles involves forming a primary emulsion using a freeze-thaw cycle of (i) an amphiphilic diblock copolymer, which has a molecular weight of about 10,000 to about 100,000 Da and comprises a conjugate of the hydrophobic polymer block and a hydrophilic polymer block, wherein the amphiphilic diblock copolymer comprises greater than 81% to about 95% by weight of the hydrophobic polymer block; and a protein having a molecular weight of up to or equal to about 300,000 Da. Various compositions comprising such filamentous-shaped nanocarrier particles, and methods of use for diagnosis and therapy are disclosed. | 12-16-2010 |
| 20100304986 | MECHANICALLY ACTUATED DIAGNOSTIC DEVICE - Disclosed are mechanically-actuated devices for transporting fluids within a microfluidic circuit and performing diagnostic operations on a sample. Also disclosed are related methods for performing sample analysis effected by the motion of an actuator proximate to a microfluidic system. | 12-02-2010 |
| 20100298281 | Steroid-Derived Cyclopamine Analogs and Methods for Using the Same in the Prevention or Treatment of Cancer - The present invention relates to steroid-derived cyclopamine analogs and methods for using the same for inhibiting sonic hedgehog signaling and preventing or treating cancer. A method for synthesizing the analogs of the present invention from a steroid is also provided. | 11-25-2010 |
| 20100291378 | FERROELECTRIC ULTRATHIN PEROVSKITE FILMS - Disclosed herein are perovskite ferroelectric thin-film. Also disclosed are methods of controlling the properties of ferroelectric thin films. These films can be used in a variety materials and devices, such as catalysts and storage media, respectively. | 11-18-2010 |
| 20100285500 | NEUROFURANS-INDICES OF OXIDANT STRESS - The invention is drawn to a new class of isoeicosanoids that have been identified as products of the oxidation of docosahexaenoic acid (DHA). The invention provides compositions and methods related to the new class of molecules. | 11-11-2010 |
| 20100285015 | TARGETING RECOMBINANT THERAPEUTICS TO CIRCULATING RED BLOOD CELLS - Fusion proteins comprising a single chain antigen-binding domain (scFv) of a monoclonal antibody, linked to an anti-thrombotic agent, anti-inflammatory agent, or a pro-drug thereof are provided, where the polypeptide binds to a binding site (antigen) expressed on the surface of a red blood cell at a density greater than 5,000 copies per red blood cell. Pharmaceutical compositions comprising these fusion proteins, and methods of delivering an anti-thrombotic agent to the surface of a red blood cell via delivery of these fusion proteins, and methods of treating or preventing thrombosis, tissue ischemia, acute myocardial infarction (AMI), ischemic stroke, cerebrovascular disease, pulmonary embolism, or ischemic peripheral vascular disease via administration of the fusion proteins or compositions comprising same are also provided. | 11-11-2010 |
| 20100278791 | ADENO-ASSOCIATED VIRUS SEROTYPE I NUCLEIC ACID SEQUENCES, VECTORS AND HOST CELLS CONTAINING SAME - The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors. | 11-04-2010 |
| 20100272688 | METHOD OF TREATING OR RETARDING THE DEVELOPMENT OF BLINDNESS - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 10-28-2010 |
| 20100266500 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES - This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits. | 10-21-2010 |
| 20100264256 | COUNTER-ROTATIONAL INERTIAL CONTROL OF ROTORCRAFT - A rotorcraft with two counter-rotating rotors and method for inertially controlling the rotorcraft. The rotorcraft includes a hinged frame configured such that at least one inter-rotor angle of the two counter-rotating rotors is controlled by at least one actuated hinge of the hinged frame and the rotational axes of the two counter-rotating rotors are substantially collinear when the actuated hinge is in a fully open position. The sum of the magnitudes of torque applied to the two counter-rotating rotors is varied to control the lift of the rotorcraft. The difference of the magnitudes of torque applied to the two counter-rotating rotors is varied to control the yaw of the rotorcraft. The at least one inter-rotor angle is varied using the at least one actuated hinge to control the pitch and/or roll of the rotorcraft. | 10-21-2010 |
| 20100260799 | SIMIAN SUBFAMILY C ADENOVIRUSES SAdV-40, -31, AND -34 AND USES THEREOF - A recombinant vector comprises simian adenovirus SAdV-31 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-31 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 10-14-2010 |
| 20100260780 | Uniform field magnetization and targeting of therapeutic formulations - Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Therapeutic particles can comprise antioxidant enzymes, and can be targeted to cells to protect the cells from oxidative damage. | 10-14-2010 |
| 20100255486 | METHOD FOR DIAGNOSING LUNG CANCERS USING GENE EXPRESSION PROFILES IN PERIPHERAL BLOOD MONONUCLEAR CELLS - Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected genes, e.g., a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile. Another composition for similar use contains a plurality of polynucleotides immobilized on a substrate, which probes hybridize to three or more gene expression products from genes in the gene expression profile. Still another composition involves detection of the protein expression products of genes from the gene expression profile. | 10-07-2010 |
| 20100254947 | SIMIAN SUBFAMILY B ADENOVIRUSES SAdV-28, -27, -29, -32, -33, AND -35 AND USES THEREOF - A recombinant vector comprises simian adenovirus 28, simian adenovirus 27, simian adenovirus 32, simian adenovirus 33, and/or simian adenovirus 35 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-28, -27, -32, -33, or -35 genes is also disclosed. Methods of using the vectors and cell lines are provided. | 10-07-2010 |
| 20100252901 | FERROELECTRIC THIN FILMS - Ferroelectric structures and methods of making the structures are presented. The ferroelectric structures can include an electrode in contact with a ferroelectric thin film. The contact can be arranged so that a portion of the atoms of the ferroelectric thin film are in contact with at least a portion of the atoms of the electrode. The electrode can be made of metal, a metal alloy, or a semiconducting material. A second electrode can be used and placed in contact with the ferroelectric thin film. Methods of making and using the ferroelectric structures are also presented. | 10-07-2010 |
| 20100247490 | SIMIAN E ADENOVIRUSES SAdV-39, -25.2, -26, -30, -37, AND -38 - A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -383 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 09-30-2010 |
| 20100247381 | PROCESSES AND APPLICATIONS OF CARBON NANOTUBE DISPERSIONS - Disclosed are copolymers of carbon nanotubes, as well as processes and applications of carbon nanotube dispersions. Carbon nanotube emulsions and related technology are also disclosed. The controlled deposition of carbon nanotubes on substrates is also provided. Methods of purifying single-walled carbon nanotubes are also provided. Devices made according to the disclosed methods are further described herein. | 09-30-2010 |
| 20100239696 | FLAXSEED LIGNAN COMPLEX, METHODS OF USING AMD COMPOSITIONS THEREOF - This invention relates to methods and compositions for treating pathological lung conditions using whole-grain flaxseed or flaxseed lignans (isolated in form of the lignan precursor Secoisolariciresinol diglucoside (SDG) directly from whole-grain flaxseed or chemically synthesized directly into the mammalian, readily metabolizable forms, Enterodiol (ED) or Enterolactone (EL). Such pathological condition result from oxidative lung injury such as ischemia-reperfusion injury (related to lung transplantation), radiation fibrosis and cancer. Specifically, the invention is directed to the use of flaxseed lignans in the treatment of acute and chronic lung injury as well as cancer. | 09-23-2010 |
| 20100239587 | ErbB Interface Peptidomimetics And Methods Of Use Thereof - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 09-23-2010 |
| 20100239565 | METHODS OF TREATMENT OF SKIN ULCERS - Methods for treating and/or preventing skin ulcers are provided featuring administration of pharmaceutical compositions comprising inhibitors of activity or expression Of Lp-PLA | 09-23-2010 |
| 20100215579 | PHEN-NAPHTHALENE AND PHEN-QUINOLINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES - This invention relates to methods of imaging amyloid deposits, radiolabeled compounds, and methods of making radiolabeled compounds useful in imaging amyloid deposits. This invention also relates to compounds and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits and methods of delivering therapeutic agents to amyloid deposits. | 08-26-2010 |
| 20100207066 | POLYMER-NANOCRYSTAL QUANTUM DOT COMPOSITES AND OPTOELECTRONIC DEVICES - Disclosed are compositions including semiconducting polymers and quantum dot nanocrystals. Also disclosed are optoelectronic devices prepared from semiconducting polymers and quantum dot nanocrystals. Also are disclosed methods of increasing the quantum efficiency in optoelectronic devices and methods of generating a photocurrent. | 08-19-2010 |
| 20100203482 | NON-BIODEGRADABLE ENDODONTIC SEALANT COMPOSITION - A non-biodegradable endodontic sealant composition comprises the reaction product of a first paste and a second paste. Either paste or both pastes include one or more of: unmodified HEMA and bioglass. The first paste includes a first polymerizing agent and the second paste includes a second polymerizing agent. A method for making the composition comprises preparing the first paste and second paste and combining the pastes under conditions to achieve a polymerization reaction initiated by a reaction between the polymerizing agents. The combining step is performed under conditions for achieving a setting time that is in a range of about 1 minute to about 1 hour. A method for treating humans having a voided region into which no re-growth will occur comprises administering the composition to the affected area, preferably to an area where tissue, tooth, or bone are not intended to re-grow. | 08-12-2010 |
| 20100191695 | CLASSIFICATION OF SUB CORTICAL STRUCTURES - Subcortical neural structures are classified during a microelectrode recording (MER) procedure. As the electrode traverses subcortical structures toward a target neural structure, neural activity is analyzed. The neural activity is converted to electrical signals. Features pertaining to characteristics of the neural activity are extracted from the electrical signals. The features are synergistically combined using fuzzy clustering logic, for example. In an example embodiment, the combined results are provided in a form of a color coded map indicating the different structural regions traversed. Observation of the map provides an objective indication of the demarcations of the various structural regions traversed and an objective technique for classifying the structural regions. | 07-29-2010 |
| 20100190270 | SYSTEM AND METHODS FOR DETECTING A GASEOUS ANALYTE IN A GAS - Systems and methods for detecting a gaseous analyte utilize a micromechanical piezoelectric resonator having a functionalization layer configured to bind with the gaseous analyte. The functionalization layer may include a layer of carbon nanotubes affixed to the resonator and coated with biopolymers configured to bind with the gaseous analyte. The gaseous analyte may be detected by operating the micromechanical piezoelectric resonator and functionalization layer in the presence of the gas, detecting a change in the resonant frequency of the resonator, and determining the concentration of the gaseous analyte from the change in resonant frequency. Finally, the layer of carbon nanotubes may be grown on the piezoelectric resonator by depositing a catalyst on a piezoelectric structure, heating the piezoelectric structure and the catalyst to enhance the growth of the carbon nanotubes, and growing the carbon nanotubes at growth sites on the piezoelectric structure. | 07-29-2010 |
| 20100189644 | ARGINASE INHIBITORS AND METHODS OF USE - The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: | 07-29-2010 |
| 20100178346 | DISC AUGMENTATION WITH HYALURONIC ACID - The present invention relates to materials comprising hyaluronic acid for replacement or augmentation of the nucleus pulposus The materials have a Poisson's ratio of 0.40 to 0.80 based on that of the human nucleus pulposus. | 07-15-2010 |
| 20100169024 | DEFINING QUANTITATIVE SIGNATURES FOR DIFFERENT GLEASON GRADES OF PROSTATE CANCER USING MAGNETIC RESONANCE SPECTROSCOPY - A method for classifying a possible cancer from a magnetic resonance spectrographic (MRS) dataset includes extracting at least one feature from the MRS dataset as being identified with the possible cancer and embedding the extracted feature into a low dimensional space to form an embedded space. The method then clusters the embedded space into clusters representing a plurality of predetermined classes and spectrally decomposing the clusters to identify substantially significant independent metabolic signatures. The method then classifies the possible cancer as belong to one of at least two cancer classes based on the identified independent metabolic signatures. | 07-01-2010 |
| 20100168207 | COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOGENESIS - RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs. | 07-01-2010 |
| 20100144535 | PARALLEL FABRICATION OF NANOGAPS AND DEVICES THEREOF - Disclosed are devices comprising multiple nanogaps having a separation of less than about 5 nm. Also disclosed are methods for fabricating these devices. | 06-10-2010 |
| 20100142259 | NANOGAPS: METHODS AND DEVICES CONTAINING SAME - Disclosed are methods of fabricating nanogaps and various devices composed of nanogaps. The nanogap devices disclosed herein can be used as in a number of electronic, photonic and quantum mechanical devices, including field-effect transistors and logic circuits. | 06-10-2010 |
| 20100136101 | COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF HIF-1 ALPHA - RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer. | 06-03-2010 |
| 20100131454 | METHOD AND SYSTEM FOR EVALUATING FEEDING PERFORMANCE OF INDIVIDUAL NEONATES - A method and system for computing a relative score indicative of an individual infant's feeding performance based, at least in part, upon a comparison of one or more feeding factor measurements of the individual infant with a corresponding databased metric that is derived from a population-based sample of infants, where the comparison optionally provides a statistical association between normative metric values and adverse outcomes recorded for the same population-based sample and, thereby, a means for assessing the tested infant's risk for said adverse outcomes. | 05-27-2010 |
| 20100116430 | ADHESIVES WITH MECHANICAL TUNABLE ADHESION - The invention concerns a method for making an article having a tunable adhesive, said method comprising applying strain to mechanically deform a substrate in at least one direction; applying a rigid coating layer on the substrate; and releasing the strain to form an article having a rippled surface. Ripple characteristics can be altered by mechanical strain in real time which further changes the adhesion properties. | 05-13-2010 |
| 20100112011 | PHOTODYNAMIC THERAPY-GENERATED MESOTHELIOMA VACCINE - This invention relates to a vaccine for mesothelioma generated using photodynamic therapy and its use in methods and compositions for treating mesothelioma. | 05-06-2010 |
| 20100098773 | POLYMER VESICLES FOR SELECTIVE ELECTROMAGNETIC ENERGY-INDUCED DELIVERY - Provided are polymer vesicles comprising polymersomes, a radiofrequency absorbing moiety, a protein or a polysaccharide associated with the inner leaflet of the membrane and a therapeutic or diagnostic cargo. The invention also concerns the use of these polymer vesicles for selective electromagnetic energy-induced delivery of therapeutic or diagnostic agents. | 04-22-2010 |
| 20100088285 | NDMA SCALABLE ARCHIVE HARDWARE/SOFTWARE ARCHITECTURE FOR LOAD BALANCING, INDEPENDENT PROCESSING, AND QUERYING OF RECORDS - A system for storing NDMA data is scalable to handle extreme amounts of data. The system allows components to be added or deleted to meet current demands. The system processes data in independent steps, providing processor level independence for every subcomponent. The system uses parallel processing and multithreading within load balancers that direct data traffic to other nodes and within all processes on the nodes themselves. The system utilizes host lists to determine where data should be directed and to determine which functions are activated on each node. Data is stored in queues which are persisted at each processing step. | 04-08-2010 |
| 20100088040 | SINGLE WALLED CARBON NANOTUBES WITH FUNCTIONALLY ADSORBED BIOPOLYMERS FOR USE AS CHEMICAL SENSORS - Chemical field effect sensors comprising nanotube field effect devices having biopolymers such as single stranded DNA or RNA functionally adsorbed to the nanotubes are provided. Also included are arrays comprising the sensors and methods of using the devices to detect volatile compounds. | 04-08-2010 |
| 20100073678 | Blast injury dosimeter - A method for detecting blast induced pressure changes includes exposing a material, a contained solution, a membrane-bound solution, or a photonic crystal material, having a first optical property, to a pressure wave having a blast level. A change in the first optical property to a second optical property of the exposed material, contained solution, membrane-bound solution, or photonic crystal material is determined, and the extent of change corresponds to the blast level. | 03-25-2010 |
| 20100061984 | COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION - Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed. Methods of identifying compounds that are useful to modulate acetylation level and/or protein level of FOXP3 and treat diseases are disclosed. | 03-11-2010 |
| 20100056423 | Bacterial-Derived BLIS for Treatment of Acne - This invention relates to a treatment of acne. Specifically, the invention is directed to the use of bacteriocin-like inhibitory substances (BLIS), isolated from | 03-04-2010 |
| 20100047913 | Colloidal Gold Single Reagent Quantitative Protein Assay - The invention provides methods for determining the concentration of polypeptides. The methods generally comprise labeling a polypeptide with a metal label such as colloidal gold and quantifiably detecting the polypeptide-metal complex; the methods are improvements over other quantification assays that use colloidal gold. The invention further provides kits for practicing the methods. | 02-25-2010 |
| 20100042208 | Percutaneous Heart Valve - A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, claws that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws in the second position, and leaflet membranes connected to the annular ring, the body member and/or the legs, the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve is designed such that upon removal of the external force the claws elastically revert to the first position so as to grip the heart tissue positioned within the claws, thereby holding the heart valve in place. The body member and claws may be integrated into a one-piece design. The heart valve may be used as a prosthesis for the mitral valve, aortic valve, pulmonary valve, or tricuspid valve by adapting the annular ring to fit in a respective mitral, aortic, pulmonary, or tricuspid valve opening of the heart. | 02-18-2010 |
| 20100041989 | USE OF ULTRASOUND AS AN ANTIVASCULAR AGENT - A method for detecting and disrupting fragile blood vessels formed as a result of tumor angiogenesis by manipulating an extent of tissue vascularity in vivo, the method includes targeting a region in need of manipulating the extent of vascularity of the tissue by a diagnostic imaging; visualizing said fragile blood vessels in the tissue; obtaining a characteristic of the tissue; and contacting the tissue with a therapeutic ultrasound producing an unfocused or mildly focused ultrasound beam having an intensity below 2.6 W/cm2, wherein the therapeutic ultrasound is emitted from an ultrasound unit in accordance with the characteristic of the tissue and thereby reducing the extent of vascularity of the tissue and disrupting said fragile blood vessels formed to support the tumor in the region of interest. | 02-18-2010 |
| 20100035349 | Biodetection Cassette with Automated Actuator - Provided are analysis cassettes that include removable sealing layers and deformable connector layers that place various channels, chambers, and reservoirs on the cassettes into fluid communication with one another. The cassettes are suitable for use in self-contained, immunoassay devices that may be operated in an automated fashion. Also disclosed are methods for analyzing samples by use of the disclosed cassettes. | 02-11-2010 |
| 20100025708 | LUMPED PLASMONIC "DIODE" AND LUMPED PLASMONIC "RECTIFIER" FOR OPTICAL FIELD RECTIFICATION AND LUMPED OPTICAL SECOND HARMONIC GENERATION - A lumped nanocircuit element design at IR and optical frequencies is provided that can effectively act as a lumped “diode” and a lumped “rectifier” for rectifying optical field displacement currents or optical electric field. The lumped nanocircuit element design can also act as a lumped second harmonic generator. The element is formed by juxtaposing an epsilon-negative nanoparticle with a nonlinear optical nanostructure. | 02-04-2010 |
| 20100013965 | SEPARATION AND CONTRAST ENHANCEMENT OF OVERLAPPING CAST SHADOW COMPONENTS AND TARGET DETECTION IN SHADOW USING POLARIZATION - Shadow is an inseparable aspect of all natural scenes. When there are multiple light sources or multiple reflections several different shadows may overlap at the same location and create complicated patterns. Shadows are a potentially good source of information about a scene if the shadow regions can be properly identified and segmented. However, shadow region identification and segmentation is a difficult task and improperly identified shadows often interfere with machine vision tasks like object recognition and tracking. A shadow separation and contrast enhancement method based on the polarization of light is provided. Polarization information of scenes is captured by a polarization-sensitive camera and the scenes are processed to effectively separate shadows from different light sources. | 01-21-2010 |
| 20090326150 | SYNTHESIS OF POLY-(P-ARYLENEETHYNYLENE)S IN NEAT WATER UNDER AEROBIC CONDIT - Provided are ethyne synthons comprising boron and related methods. Also provided are related water-soluble arylethynylene polymers capable of being synthesized in neat water under aerobic conditions. | 12-31-2009 |
| 20090317417 | Modified AAV Vectors Having Reduced Capsid Immunogenicity and Use Thereof - A method of reducing the cellular immune response and/or toxicity of AAV-mediated delivery is described. The method provides for masking or ablating a RxxR motif which induces T-cells, and which is located on select AAV capsids. The method further provides for reducing or eliminating heparin binding to an AAV. Also provided are compositions containing modified AAV capsids and methods of using same. | 12-24-2009 |
| 20090316971 | MOTION ARTIFACT COMPENSATION - A technique for correcting translational and rotational motion of an object, such as an object in a magnetic field, utilizes the k-space representation of the object. An initial region in the k-space representation is used as a motion-free reference region, indicative of the motion-free object. Motion-free data adjacent to the initial region are then estimated by extrapolating from the initial region, and the extrapolated data are subsequently used to estimate motion by correlating it with actual data. Segments adjacent to the initial region are then motion corrected and incorporated into an expanding base region. The expanded base region is used in subsequent correction steps. This process is continued until the entire k-space is motion-corrected. Two different extrapolation methods were used for the purpose of motion estimation: edge enhancement and finite-support solution. One technique is utilized near the k-space center and the other is utilized in the outer k-space regions. | 12-24-2009 |
| 20090313368 | CROSS-ENTERPRISE WALLPLUG FOR CONNECTING INTERNAL HOSPITAL/CLINIC IMAGING SYSTEMS TO EXTERNAL STORAGE AND RETRIEVAL SYSTEMS - A WallPlug (interface) connects DICOM devices located at a hospital to external storage and retrieval systems. The external storage and retrieval systems can be part of the National Digital Mammography Archive. The WallPlug allows secure communications within the hospital setting, and allows only selected data to be transferred between the hospital devices and the archive. The WallPlug enables cross-enterprise distribution of medical content with proper authentication and logging of transfers. The WallPlug includes two portals connected together by a private secure network. The use of two separate devices greatly enhances the security, redundancy, and manageability of the combined device. | 12-17-2009 |
| 20090306030 | Methods Of Inhibiting Osteoclast Activity - Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the methods, an amount of a TRANCE/RANK inhibitor effective to inhibit osteoclastogenesis is administered to the patient. Pharmaceutical compositions which comprise TRANCE/RANK inhibitor in an amount effective to inhibit osteoclastogenesis. Methods of modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems in an individual are disclosed. The methods comprise the step of administering to the individual an amount of a TRANCE/RANK inhibitor effective to modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems. | 12-10-2009 |
| 20090306014 | C-10 CARBAMATES OF TAXANES - Provided herein are C-10 taxane carbamates and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating cancer and taupathy. | 12-10-2009 |
| 20090304627 | SMALLPOX DNA VACCINE AND THE ANTIGENS THEREIN THAT ELICIT AN IMMUNE RESPONSE - The present invention relates to DNA vaccines that are capable of generating a protective immune response in mammals against a pox virus, and comprises at least one DNA plasmid capable of expressing a plurality of VACV MV antigens, and at least one DNA plasmid capable of expressing a plurality of VACV EV antigens. Also, the present invention relates to methods of inducing a protective immune response in a mammal to pox virus, including a neutralizing antibody response, comprising: injecting into tissue of said mammal said DNA vaccine. | 12-10-2009 |
| 20090287185 | Cardiac Targeted Delivery of Cells - A method of delivering cardiac stem cell and treating damaged cardiac tissue is provided. The method involves isolation of subject's cardiac circulation from the subject's systemic circulation and perfusing a solution comprising stem cells into the cardiac circuit. | 11-19-2009 |
| 20090285827 | ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS - The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention. | 11-19-2009 |
| 20090275107 | Scalable Production Method for AAV - A method for producing AAV, without requiring cell lysis, is described. The method involves harvesting AAV from the supernatant. For AAV having capsids with a heparin binding site, the method involves modifying the AAV capsids and/or the culture conditions to ablate the binding between the AAV heparin binding site and the cells, thereby allowing the AAV to pass into the supernatant, i.e., media. Thus, the method of the invention provides supernatant containing high yields of AAV which have a higher degree of purity from cell membranes and intracellular materials, as compared to AAV produced using methods using a cell lysis step. | 11-05-2009 |
| 20090263824 | Detection of Neurodegenerative Disease - Provided are methods of assessing the absence or presence of a neurodegenerative disease in a subject comprising characterizing TDP-43 in a tissue sample of the subject. Also disclosed are methods for diagnosing a neurodegenerative disease in a subject, and methods for determining the efficacy of a drug against a neurodegenerative disease. Novel antibodies that bind to TDP-43 are also provided. | 10-22-2009 |
| 20090258078 | ANTIOXIDANT POLYMER NANOCARRIERS FOR USE IN PREVENTING OXIDATIVE INJURY - The present invention is a method for encapsulating active protein in a polymeric nanocarrier. The instant method employs homogenization at subzero temperatures so that enzyme activity is retained. Enzymes which can be encapsulated by the present method include, for example, antioxidant enzymes and xenobiotic detoxifying enzymes. Encapsulation of an enzyme protects it from protease degradation and increases therapeutic half-life. Advantageously, polymeric nanoparticles of the invention are permeable to enzyme substrates and therefore enzymes encapsulated by the instant method can exert their effect without release from the nanocarrier. Methods for decomposing a reactive oxygen species, protecting against vascular oxidative stress, and detoxifying a xenobiotic are also provided. | 10-15-2009 |
| 20090246888 | NANOASSAYS - The present invention provides assays of nanometer-level dimension. | 10-01-2009 |
| 20090227030 | Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor - Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. | 09-10-2009 |
| 20090221484 | Use of Factor VII Polypeptides for Neuroprotection - New methods and compositions for providing neuroprotection in gyrencephalic mammals comprising a neuroprotective dose of Factor Vila or a neuroprotective Factor Vila equivalent are provided. | 09-03-2009 |
| 20090215871 | Simian adenovirus vectors and methods of use - A recombinant vector comprises a simian adenovirus capsid and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 08-27-2009 |
| 20090214419 | SELF-ASSEMBLED BIODEGRADABLE POLYMERSOMES - The invention concerns a block copolymer of polyethylene oxide and polycaprolactone, the polyethylene oxide having a number average molecular weight from about 2.0 to about 3.8 kD, the block copolymer having a fraction of polyethylene oxide of from about 11.8 to 18.8 percent by weight. The invention also concerns polymersomes made from such copolymers and to methods of making the polymersomes. | 08-27-2009 |
| 20090198259 | APPARATUS AND METHOD FOR FACILITATING ACCESS TO VESSELS - A device and method for facilitating access to a perimeter surface of a body structure is provided. The device includes an elongate flexible member configured to be positioned adjacent the perimeter surface of the body structure, an atraumatic tip positioned at a distal end of the elongate flexible member, and an elongate body. The elongate body has a surface positioned to guide the elongate flexible member and to permit longitudinal movement of the flexible member with respect to the elongate body. The body also has a curved distal portion and a distal end for releasably engaging the atraumatic tip. | 08-06-2009 |
| 20090191263 | COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF HIF-1 ALPHA - RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer. | 07-30-2009 |
| 20090187031 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof - Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided. | 07-23-2009 |
| 20090186357 | Integrated PCR Reactor for Cell Lysis, Nucleic Acid Isolation and Purification, and Nucleic Acid Amplication Related Applications - Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis. | 07-23-2009 |
| 20090177637 | NDMA DB SCHEMA, DICOM TO RELATIONAL SCHEMA TRANSLATION, AND XML TO SQL QUERY TRANSLATION - A translation scheme translates DICOM content into a format compatible for storage in an NDMA relational database. The translation scheme employs a schema for indexing the DICOM content, and employs a mechanism for translating queries embedded in XML into SQL. The translation scheme translates DICOM compatible data into a tab delimited flat representation of the DICOM content. The flat representation is then translated into data compatible with a relational database format, such as SQL, and then into database insert commands. The schema enables capture of the DICOM information into relational tables. Methods are also provided to service XML formatted research and clinical queries, to translate XML queries to optimized SQL and to return query results to XML specified destinations with record de-identification where required. Methods are also provided to interface to NDMA WallPlugs, secured query devices, or GRID devices. | 07-09-2009 |
| 20090175858 | Crystalline EGFR - matuzumab complex and matuzumab mimetics obtained thereof - The invention relates to a crystal complex formed by the extracellular domain of EGF receptor (EGFR) and the Fab fragment of anti-EGFR antibody matuzumab (EMD 72000). Especially the invention relates to the identification of the epitope regions on said EGFR, which the antibody matuzumab recognizes as antigen an to which it specifically binds. The invention relates furthermore to protein, peptide and antibody structures which mimic the binding of matuzumab to its epitope region on EGFR, and may be used therefore, as EGFR antagonists with similar or improved properties as compared to matuzumab. | 07-09-2009 |
| 20090163563 | Phorboxazole Compounds and Methods of Their Preparation - Novel macrolactone compounds, their methods of preparation, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the macrolactone compounds may be useful, inter alia, for treating various cancers, inducing apoptosis in malignant cells, or inhibiting cancer cell division. | 06-25-2009 |
| 20090157837 | NDMA SOCKET TRANSPORT PROTOCOL - Data transferred between devices | 06-18-2009 |
| 20090136428 | High Throughput Genetic Screening Of Lipid And Cholesterol Processing Using Fluorescent Compounds - The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid and/or cholesterol processing in a vertebrate; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism in the vertebrate. | 05-28-2009 |
| 20090136105 | RETRIEVAL SYSTEM AND RETRIEVAL METHOD FOR RETRIEVING MEDICAL IMAGES - A retrieval system for retrieving medical images is provided. The retrieval system includes an archive for storing medical images, a routing device for determining selected medical images stored in the archive and for routing the selected medical images based on routing rules, and a plurality of end-user devices for use with the medical images for medical diagnosis, the selected medical images stored in the archive being automatically routed via the routing device from the archive to respective one or ones of the end-user devices. | 05-28-2009 |
| 20090130104 | FUSION PROTEINS FOR INHIBITION AND DISSOLUTION OF COAGULATION - Fusion proteins containing a ligand which specifically binds to a selected vascular bed linked to an anti-thrombotic molecule are provided. Also provided are methods for use of these fusion proteins to prevent coagulation, to dissolve blood clots and to protect against the risk of iatrogenic side effects including those arising from cancer therapy and specific vascular occluding agents. | 05-21-2009 |
| 20090123369 | Styrylpyridine Derivatives and Their Use for Binding and Imaging Amyloid Plaques - This invention relates to a method of imaging amyloid deposits and to styrylpyridine compounds, and methods of making radiolabeled styrylpyridine compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits. | 05-14-2009 |
| 20090110741 | METHOD AND COMPOSITIONS FOR POLYMER NANOCARRIERS CONTAINING THERAPEUTIC MOLECULES - A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The primary emulsion is formed using a freeze-thaw cycle of the amphiphilic diblock copolymer and a protein having a molecular weight of up to or equal to 300,000 Da. Selection of the hydrophobic polymer block percentage alters one or more characteristics of the resulting nanoparticles, such as shape. Thus, as one aspect, a method of producing filamentous polymeric nanocarrier-encapsulated protein (i.e., active enzyme) particles involves forming a primary emulsion using a freeze-thaw cycle of (i) an amphiphilic diblock copolymer, which has a molecular weight of about 10,000 to about 100,000 Da and comprises a conjugate of the hydrophobic polymer block and a hydrophilic polymer block, wherein the amphiphilic diblock copolymer comprises greater than 81% to about 95% by weight of the hydrophobic polymer block; and a protein having a molecular weight of up to or equal to about 300,000 Da. Various compositions comprising such filamentous-shaped nanocarrier particles, and methods of use for diagnosis and therapy are disclosed. | 04-30-2009 |
| 20090104614 | QUANTITATIVE MOLECULAR PROBES - In accordance with this invention, a molecular probe for detection of a nucleic acid target containing a preselected target sequence is constructed and has at least two sources of a signal: a conventional reporter source and a reference source in a form of a luminescent material, e.g., a fluorophore, quantum dot, fluorescent nanoparticle, or other fluorescent reference dye/nanoparticle/microparticle conjugated to the molecular probe. | 04-23-2009 |
| 20090104260 | COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ICAM-1 - RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory and autoimmune diseases, diabetic retinopathy and other complications arising from type I diabetes, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs. | 04-23-2009 |
| 20090104259 | COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOGENESIS - RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs. | 04-23-2009 |
| 20090076142 | USE OF THE IRRITATING PRINCIPAL OLEOCANTHAL IN OLIVE OIL, AS WELL AS STRUCTURALLY AND FUNCTIONALLY SIMILAR COMPOUNDS - The invention provides methods of synthesizing the purified enantiomers of oleocanthal. The invention further provides methods of using oleocanthals in various formulations including, food additives; pharmaceuticals; cosmetics; animal repellants; and discovery tools for mammalian irritation receptor genes, gene products, alleles, splice variants, alternate transcripts and the like. | 03-19-2009 |
| 20090074810 | Modified Adenovirus Hexon Protein and Uses Thereof - The present invention provides a method of altering the specificity of an adenovirus vector. The method involves providing an adenovirus having a capsid with a modified adenovirus hexon protein. The modified adenovirus has a capsid comprising a hexon protein with a deletion in hypervariable region 1 and/or hypervariable region 4 of the hexon and an insert of an exogenous molecule therein. | 03-19-2009 |
| 20090074723 | Method of Treating or Retarding the Development of Blindness - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 03-19-2009 |
| 20090054823 | Perfusion circuit and use therein in targeted delivery of macromolecules - A perfusion circuit and a use thereof for delivering a substance to a subject's heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit ( | 02-26-2009 |
| 20090035223 | BIOMIMETIC IRON-OXIDE-CONTAINING LIPOPROTEIN AND RELATED MATERIALS - An engineered lipoprotein including (a) a core particle or a plurality of core particles, each core particle has (i) an inner part comprising a hydrophilic active agent and a hydrophilic portion of an amphiphilic cholesterol and (ii) an outer part including a hydrophobic portion of the amphiphilic cholesterol, (b) a layer surrounding the core particle or a plurality of core particles, the layer includes a phospholipid, (c) an apoprotein associated with the layer, and optionally, (d) a homing molecule associated with at least one of the apoprotein or the phospholipid. | 02-05-2009 |
| 20090023593 | In situ cloning from pathological tissue specimens - The present invention pertains to methods related to cloning nucleic acids from biological samples, particularly pathological tissue samples. This method includes hybridizing a population of oligonucleotide sequence probes comprising degenerate sequence tags to a fixed tissue, isolating the hybridized oligonucleotide sequence probes and amplifying the sequence tags in the hybridized oligonucleotide sequence probes. This method can be utilized to identify genes associated with disease and to quantitate the expression of disease-related transcripts. The method can also be used to identify truncated mRNAs. | 01-22-2009 |
| 20090020752 | RESISTANCE-SWITCHING OXIDE THIN FILM DEVICES - Resistance-switching oxide films, and devices therewith, are disclosed. Resistance-switching oxide films, according to certain preferred aspects of the present invention, include at least about 75 atomic percent of an insulator oxide matrix having a conducting material dopant in an amount up to about 25 atomic percent. The matrix and dopant are preferably in solid solution. The insulator oxide matrix may also preferably include about 6 to about 12 atomic percent of a conducting material dopant. According to certain aspects of the present invention, the insulator oxide matrix, the conducting material dopant, or both, may have a perovskite crystal structure. The insulator oxide matrix may preferably include at least one of LaAlO | 01-22-2009 |
| 20080317761 | Peptide-Mediated Protein Transduction Into Cells of the Hematopoietic Lineage - A pharmaceutical composition comprises a therapeutic peptide or protein, a transport moiety capable of transporting said first peptide or protein into a hematopoietic cell differentiated from a common myeloid progenitor, and a linker between said first protein and said transport moiety, said linker susceptible to cleavage by an intracellular enzyme in the cell. A cell or collection of cells, e.g., platelets, containing such a composition is useful in methods for treating infection, inflammation, vascular injuries or any disorders involving or mediated by cells of the hematopoietic lineage. Methods of making such compostions are also disclosed. | 12-25-2008 |
| 20080305087 | Device and Method Using Integrated Neuronal Cells and an Electronic Device - The present invention provides a device of integrated neuronal cells interfaced with an electronic device and a method of producing the same. | 12-11-2008 |
| 20080300179 | Bowman-Birk Inhibitor Compositions for Treatment of Muscular Atrophy and Degenerative Muscle Disease - Methods for use of a composition comprising Bowman-Birk Inhibitor (BBI) or a derivative thereof in the treatment and/or prevention of skeletal muscle atrophy, to improve of skeletal muscle function, and to alleviate symptoms and/or slow progression of degenerative skeletal muscle diseases or disorders are provided. | 12-04-2008 |
| 20080291309 | CURRENT/VOLTAGE MODE IMAGE SENSOR WITH SWITCHLESS ACTIVE PIXELS - A voltage and current mode active pixel sensor for high resolution imaging is presented. The photo pixel is composed of a photodiode and two transistors: reset and transconductance amplifier transistor. The switch transistor is moved outside the pixel, allowing for lower pixel pitch and increased linearity of the output photocurrent. The reset and amplifier (readout) transistors may also be shared among adjacent pixels by the introduction of transfer switches between the photodiodes and the source of the reset transistor and the gate of the readout transistor. The switch transistor outside the pixels provides biasing voltages or currents to the readout transistors to selectively turn them on when readout of the corresponding photodiode is desired and turns the readout transistor off when the corresponding photodiode is not to be read out. The increased linearity of the image sensor has greatly reduced spatial variations across the image after correlated double sampling and the column fix pattern noise is greatly improved. | 11-27-2008 |
| 20080289965 | System and Method for Controlling Nanoparticles Using Dielectrophoretic Forces - The present invention is directed to the use of dielectrophoretic forces for the arbitrary manipulation of micrometer- and nanometer-sized particles and to devices capable of arbitrarily manipulating micrometer- and nanometer-sized particles by means of dielectrophoretic forces within a two- or three-dimensional region. The devices and methods of the invention are capable of arbitrarily controlling the velocities, locations, and forces applied to a particle, arbitrarily specifying a force or set of forces at a location in space, and determining friction and/or drag coefficients of a particle, and are thus well-suited for a range of applications including cell sorting, drug delivery, as a diagnostic tool for determining membrane stiffness, and in the heterogeneous integration of micro- and nano-components through directed assembly. | 11-27-2008 |
| 20080286856 | Nanostructure Enhanced Luminescent Devices - The present invention relates to nanostructures for use in luminescent devices. | 11-20-2008 |
| 20080275019 | METAL COMPLEX PROTEIN KINASE INHIBITORS - This inventive subject matter relates to novel metal complex protein kinases inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by kinase activity. | 11-06-2008 |
| 20080274912 | Single Walled Carbon Nanotubes Functionally Adsorbed to Biopolymers for Use as Chemical Sensors - Chemical field effect sensors comprising nanotube field effect devices having biopolymers such as single stranded DNA functionally adsorbed to the nanotubes are provided. Also included are arrays comprising the sensors and methods of using the devices to detect volatile compounds. | 11-06-2008 |
| 20080269838 | REGULATION OF GENES VIA APPLICATION OF SPECIFIC AND SELECTIVE ELECTRICAL AND ELECTROMAGNETIC SIGNALS - Methods and devices for the regulation of gene expression by cells via the application of fields generated by specific and selective electric and electromagnetic signals so as to target diseased or injured tissue for treatment. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased tissue that include providing specific and selective electric and electromagnetic signals and exposing tissue to the fields generated by the signals so as to regulate gene expression. In particular, methods and devices are provided for the targeted treatment of bone defects, osteoarthritis, osteoporosis, cancer, and other disease states. | 10-30-2008 |
| 20080269259 | Regulation of Autophagy and Cell Survival - Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering to such an individual a combination of an anti-cancer composition that renders the cancer incapable of glycolysis and an autophagy inhibitor. Pharmaceutical compositions and kits comprising that renders the cancer incapable of glycolysis and an autophagy inhibit are also disclosed. Methods of treating an individual who has a disease characterized b cell degeneration and cell death due to autophagy are disclosed. The methods comprise administering to the individual a permeable form of a metabolic substrate that can be oxidized in the tricarboxylic acid cycle to produce NADH. Methods for identifying an autophagy inhibitor comprising performing a test assay using an apopto sis-resistant cell are disclosed. | 10-30-2008 |
| 20080269112 | Antineoplastic Agents Targeted via Glut Transporters - The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neoplastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The inventions also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters. | 10-30-2008 |
| 20080249053 | Compositions And Methods For Detecting And Treating Neurological Conditions - The present invention relates to the NIPA-1 proteins and nucleic acids encoding the NIPA-1 proteins. The present invention further provides assays for the detection of NIPA-1 polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NIPA-1 proteins. | 10-09-2008 |
| 20080242742 | Animal models of pancreatic adenocarcinoma and uses therefor - The present invention is based, at least in part, on the generation of an animal model of pancreatic adenocarcinoma which recapitulates the genetic and histological features of human pancreatic adenocarcinoma, including the initiation, maintenance, and progression of the disease. Accordingly, the present invention provides animal models of cancer, e.g., pancreatic adenocarcinoma, wherein an activating mutation of Kras has been introduced, and any one or more known or unknown tumor suppressor genes or loci, e.g., Ink4a/Arf, Ink4a, Arf, p53, Smad4/Dpc, Lkb1, Brca2, or Mlh1, have been misexpressed, e.g., have been misexpressed leading to decreased expression or non-expression. The animal models of the invention may be used, for example, to identify biomarkers of pancreatic cancer, to identify agents for the treatment or prevention of pancreatic cancer, and to evaluate the effectiveness of potential therapeutic agents. | 10-02-2008 |
| 20080242623 | Microutrophin and Uses Thereof - A microutrophin containing a utrophin having internal deletions (relative to a native utrophin) in the hinge regions and a C-terminal deletion is provided. Also provided are vectors and compositions useful for delivering the microutrophin for the treatment of muscular disorders, including Duchenne Muscular Dystrophy. | 10-02-2008 |
| 20080241189 | Sequential Delivery Of Immunogenic Molecules Via Adenovirus And Adeno-Associated Virus-Mediated Administrations - An immunogenic regimen is provided. The regimen involves sequential administration of a recombinant adenoviral vector and a recombinant adeno-associated viral vector, each of which delivers a heterologous expression cassette encoding the same immunogenic product, or a cross-reactive immunogenic product. Also provided are products containing the vectors for use in the regimen of the invention. | 10-02-2008 |
| 20080221672 | Mitral Valve System - Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis. | 09-11-2008 |
| 20080219954 | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins - Chimpanzee serotype C68 proteins, peptides, and polypeptide are provided. Also provided are novel adenoviruses derived from these proteins, as well as compositions containing these proteins and methods of using same for immunization and therapy. Further, a rapid method for screening recombinant transformants using a visually detectable method is described. | 09-11-2008 |
| 20080215116 | REGULATION OF FIBROBLASTIC GROWTH FACTOR-2 (FGF-2) GENE EXPRESSION IN LIVING CELLS WITH THE APPLICATION OF SPECIFIC AND SELECTIVE ELECTRIC AND ELECTROMAGNETIC FIELDS - Methods and devices are described for the regulation of Fibroblastic Growth Factor-2 mRNA and/or FGF-2 protein in bone cells and other tissues via capacitive coupling or inductive coupling of specific and selective electric and/or electromagnetic fields to the bone cells or other tissues, where the specific and selective fields are generated by application of specific and selective signals to electrodes or one or more coils or other field generating device disposed with respect to the bone cells or other tissues so as to facilitate the treatment of diseased or injured bone and other tissues. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone and other tissue that include generating specific and selective signals that generate electric and/or electromagnetic fields in the target tissue optimized for increase of FGF-2 protein gene expression and exposing bone and other tissue to the fields generated by specific and selective signals so as to regulate FGF-2 protein gene expression in such tissue. The resulting methods and devices are useful for the targeted treatment of osteoporosis, osteopenia, osteonecrosis, fresh bone fractures, fractures at risk, nonunion, bone defects, spine fusion, and/or other conditions in which FGF-2 protein has been implicated. | 09-04-2008 |
| 20080212920 | Optical Circuits and Circuit Elements and Methods of Forming Same - Circuits and circuit elements adapted to function at optical or infrared frequencies are made from plasmonic and/or nonplasmonic particles disposed on a substrate, where the plasmonic and nonplasmonic particles have respective dimensions substantially smaller than a wavelength of an applied optical or infrared signal. Such particles are deposited on a substrate in a variety of shapes and sizes from a variety of plasmonic and/or nonplasmonic materials so as to form resistors, capacitors, inductors and circuits made from combinations of these elements. | 09-04-2008 |
| 20080208332 | Valve Prosthesis Systems and Methods - Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region. The positioning elements are adapted to substantially completely invert by rotating relative to the resilient ring between a first position in which each of the first and second tissue engaging regions is inwardly directed for facilitating positioning of the valve prosthesis within a delivery catheter, and a second position in which each of the first and second tissue engaging regions is outwardly directed for engaging tissue. The valve prosthesis may also include a valve skirt mounted with respect to the resilient ring. | 08-28-2008 |
| 20080208328 | Systems and Methods For Placement of Valve Prosthesis System - Valve prosthesis systems and methods/systems for placement of such valve prostheses are provided that facilitate efficient, reliable and minimally invasive delivery modalities. The placement systems and methods permit remote manipulation and positioning of the valve prosthesis such that desirable placement relative to anatomical structures, e.g., the heart annulus, may be achieved. The valve prosthesis includes a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. The delivery system includes a first elongate element that terminates at the valve prosthesis and is manipulable by an operator to remotely rotate the positioning elements relative to the flexible ring. A second elongate element terminates at the valve prosthesis and is manipulable by an operator to remotely advance the valve prosthesis downward into an anatomical annulus. The second elongate element may be manipulated to remotely advance the valve prosthesis into the anatomical annulus to assume a position for supporting post-implantation function of the valve prosthesis in situ. The first elongate element may be further manipulated to remotely rotate the positioning element relative to the flexible ring to cause the positioning element to engage tissue associated with the anatomical annulus and to thereby maintain the post-implantation position of the valve prosthesis in situ. Methods for valve prosthesis deployment are also provided. | 08-28-2008 |
| 20080208033 | MULTI-SLICE CEREBRAL BLOOD FLOW IMAGING WITH CONTINUOUS ARTERIAL SPIN LABELING MRI - This invention is a method for multi-slice CBF imaging using continuous arterial spin labeling (CASL) with an amplitude modulated control which is both highly effective at controlling for off resonance effects, and efficient at doubly inverting inflow spins, thus retaining the signal advantages of CASL versus pulsed ASL techniques. | 08-28-2008 |
