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The Trustees of teh University of Pennsylvania

The Trustees of teh University of Pennsylvania Patent applications
Patent application numberTitlePublished
20090197338Method of Increasing the Function of an AAV Vector - A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.08-06-2009