THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK Patent applications |
Patent application number | Title | Published |
20160139120 | RAGE AS A C1Q RECEPTOR, METHODS AND APPLICATIONS - A method of identifying a compound capable of reducing or increasing the amount of the receptor for RAGE-C1q Binding comprising a) providing an amount of the compound to be tested; b) contacting the amount of the compound with C1q and RAGE; c) measuring the amount of RAGE-C1q binding in step b); d) comparing the amount of RAGE-C1q binding measured in step c) with the amount of RAGE-C1q binding measured under corresponding conditions in the absence of the compound; and e) identifying the compound as capable of reducing or increasing the amount of RAGE-C1q binding. The present invention also provides a method of treating a subject suffering from a RAGE-related disorder comprising administering to the subject a therapeutically effective amount of a compound that is a modulator of the amount of RAGE-C1q binding so as to thereby treat the subject. | 05-19-2016 |
20160120805 | EXOSOMES FOR OROFACIAL DIAGNOSTICS AND THERAPEUTICS - Provided are methods of treating a subject with a composition comprising an exosome or a polypeptide, RNA, or miRNA contained therein or identified or isolated therefrom. Also provided are methods of promoting dentinogenesis, amelogenesis, or osteogenesis. Also provided are compositions comprising an exosome or a polypeptide, RNA, or miRNA contained therein or identified or isolated therefrom. | 05-05-2016 |
20160119137 | DIVERSIFIED INSTRUCTION SET PROCESSING TO ENHANCE SECURITY - Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method that includes receiving a block of information from non-processor memory at an interface between the non-processor memory and processor memory comprising two or more processor memory levels, determining whether the block of information received from the non-processor memory at the interface corresponds to encrypted instruction code, and decrypting the block of information at the interface between the non-processor memory and the processor memory for storage in one of the two or more levels of the processor memory in response to a determination that the received block of information corresponds to the encrypted instruction code. The block of information is stored at the one of the two or more levels of the processor memory without being decrypted when the received block of information is determined to correspond to data. | 04-28-2016 |
20160115217 | COMPOSITIONS OF HUMANIZED NOTCH FUSION PROTEINS AND METHODS OF TREATMENT - This invention provides a fusion protein comprising a signal peptide, an extracellular domain of human Notch receptor protein and an Fc portion of an antibody bound thereto. This invention also provides a method for treating a subject having a tumor, a method for inhibiting angiogenesis in a subject, a method for treating a subject having ovarian cancer, and a method for treating a subject having a metabolic disorder, comprising administering to the subject an amount of the above fusion protein effective to treat the subject. This invention further provides uses of the above fusion protein for the preparation of a pharmaceutical composition for the treatment of a subject having a tumor, for inhibiting angiogenesis in a subject, for treating a subject having ovarian cancer, and for treating a subject having a metabolic disorder. | 04-28-2016 |
20160107000 | APPARATUS, METHOD, AND SYSTEM FOR SELECTIVELY EFFECTING AND/OR KILLING BACTERIA - Certain exemplary embodiments of the present disclosure can provide an apparatus and method for generating at least one radiation can be provided. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range can be provided. | 04-21-2016 |
20160104077 | System and Method for Extracting Table Data from Text Documents Using Machine Learning - Systems and methods for extracting table data from text documents using machine learning are provided. The systems and methods comprise electronically receiving at a computer system a document having one or more tables, each table having one or more whitespace features, processing the document using a first computer model executed by the computer system to classify each row of the one or more tables as a header row or a data row, processing the document using a second computer model executed by the computer system to classify each whitespace feature in each row conditional on classification of each row by the first computer model, the second computer model identifying whether a whitespace feature corresponds to information missing from the one or more tables, and generating an output of the classified whitespace features and storing the output in a digital file. | 04-14-2016 |
20160103823 | Machine Learning Extraction of Free-Form Textual Rules and Provisions From Legal Documents - Disclosed herein is a system and method for machine learning extraction of free-form textual rules and provisions from legal documents. The method comprising electronically receiving, by the legal rules extraction engine, a document, processing the document using a first trained model executed by the legal rules extraction engine to classify the document into a document class, processing the document using a second trained model executed by the legal rules extraction engine to extract rules within the document conditional on the document class identified by the first trained model, extracting a plurality of data variables from the document by processing the classified features in the document using a third trained model executed by the legal rules extraction engine, generating by the legal rules extraction engine an output vector based on the plurality of data variables, and displaying the output vector by the legal rules extraction engine at the user interface. | 04-14-2016 |
20160102367 | RECURRENT MUTATIONS IN EPIGENETIC REGULATORS, RHOA AND FYN KINASE IN PERIPHERAL T-CELL LYMPHOMAS - Whole exome sequencing of 12 tumor-normal DNA pairs, RNAseq analysis and targeted deep sequencing identified new genetic alterations in PTCL transformation. These analyses identified highly recurrent epigenetic factor mutations in TET2, DN-MT3A and IDH2 as well as a new highly prevalent RHOA p.Gly17Val (NM_001664) mutation present in 22/35 (67%) of angioimmunoblastic T-cell lymphomas (AITL) and in 8/44 (18%) not otherwise specified PTCL (PTCL NOS) samples. Mechanistically, the RHOA Gly17Val protein interferes with RHOA signaling in biochemical and cellular assays, an effect potentially mediated by the sequestration of activated Guanine Exchange Factor (GEF) proteins. In addition, new and recurrent, genetic defects are described including mutations in FYN, ATM, B2M and CD58 implicating SRC signaling, impaired DNA damage response and escape from immune surveillance mechanisms in the pathogenesis of PTCL. | 04-14-2016 |
20160098401 | MULTIMEDIA INTEGRATION DESCRIPTION SCHEME, METHOD AND SYSTEM FOR MPEG-7 - The invention provides a system and method for integrating multimedia descriptions in a way that allows humans, software components or devices to easily identify, represent, manage, retrieve, and categorize the multimedia content. In this manner, a user who may be interested in locating a specific piece of multimedia content from a database, Internet, or broadcast media, for example, may search for and find the multimedia content. In this regard, the invention provides a system and method that receives multimedia content and separates the multimedia content into separate components which are assigned to multimedia categories, such as image, video, audio, synthetic and text. Within each of the multimedia categories, the multimedia content is classified and descriptions of the multimedia content are generated. The descriptions are then formatted, integrated, using a multimedia integration description scheme, and the multimedia integration description is generated for the multimedia content. The multimedia description is then stored into a database. As a result, a user may query a search engine which then retrieves the multimedia content from the database whose integration description matches the query criteria specified by the user. The search engine can then provide the user a useful search result based on the multimedia integration description. | 04-07-2016 |
20160090621 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS - This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto. | 03-31-2016 |
20160087951 | SYSTEMS AND METHODS FOR INHIBITING ATTACKS WITH A NETWORK - Systems and methods for inhibiting attacks with a network are provided. In some embodiments, methods for inhibiting attacks by forwarding packets through a plurality of intermediate nodes when being transmitted from a source node to a destination node are provided, the methods comprising: receiving a packet at one of the plurality of intermediate nodes; determining at the selected intermediate node whether the packet has been sent to the correct one of the plurality of intermediate nodes based on a pseudo random function; and forwarding the packet to the destination node, based on the determining. In some embodiments an intermediate node is selected based on a pseudo random function. In some embodiments, systems and methods for establishing access to a multi-path network are provided. | 03-24-2016 |
20160077004 | CONJUGATES OF NANO-DIAMOND AND MAGNETIC OR METALLIC PARTICLES - Techniques for imaging a characteristic of a sample with a plurality of conjugates of diamond-metallic nanoparticles having a nitrogen vacancy center. The plurality of conjugates can be exposed to a sample and the nitrogen vacancy centers can be optically pumped. One or more microwave pulses can be applied to the nitrogen vacancy center, and a fluorescent response can be detected. | 03-17-2016 |
20160076021 | APTAMER METHODS AND COMPOSITIONS - Methods of selecting an aptamer that specifically binds to a target molecule complexed with a derivatization agent. Also disclosed are specific aptamers and methods of use thereof. | 03-17-2016 |
20160074678 | PLANNING SYSTEM FOR TARGETING TISSUE STRUCTURES WITH ULTRASOUND - The disclosed subject matter provides systems and methods for targeting tissue structures and applying ultrasound thereto. A method according to the disclosed subject matter for targeting a tissue structure using corresponding tissue structure image data includes inputting the tissue structure image data into a targeting simulator, determining acoustic properties of the tissue structure from the corresponding tissue structure image data, and utilizing the determined acoustic properties to align a simulated transducer with the tissue structure such that the tissue structure is targeted. The method can further include acquiring the tissue structure image data, aligning the image data with an atlas of a body structure encompassing the tissue structure and/or selecting parameters of the simulated transducer such that a focal region of an ultrasound wave generated by the simulated transducer targets the tissue structure. | 03-17-2016 |
20160068807 | METHODS FOR COMPACT AGGREGATION OF DERMAL CELLS - The invention provides for a method for aggregating dermal papilla cells or dermal sheath cells or a combination thereof, the method comprising: growing dermal papilla cells or dermal sheath cells or a combination thereof in suspension culture; and contacting the culture with an effective amount of an enzyme, wherein a substrate of the enzyme is an extracellular matrix molecule in the suspension culture, so as to aggregate dermal papilla cells or dermal sheath cells. The culture may be a hanging drop culture and the enzyme may be a hyaluronidase. | 03-10-2016 |
20160067301 | ANTAGONISM OF ABCG4, LYN KINASE, AND C-CBL E3 LIGASE TO INCREASE PLATELET COUNT AS THERAPY FOR THROMBOCYTOPENIA - The present invention provides a method of treating a subject to increase the subject's platelet count which comprises administering to the subject an amount of one or more of an antagonist or inhibitor of ABCG4, Lyn kinase or c-CBL effective to antagonize or inhibit such ABCG4, Lyn kinase or c-CBL so as to thereby increase the subject's platelet count. | 03-10-2016 |
20160058912 | SCAFFOLDS FOR PROMOTING CALCIFIED CARTILAGE AND/OR BONE FORMATION - Biomimetic hydrogel and selected ceramic interface scaffolds useful in regenerating calcified cartilage and promoting stable and integrative cartilage repair are provided. An aspect of this application relates to scaffolds for promoting calcified cartilage and/or bone formation. The scaffolds of this application comprise a biomimetic hydrogel and a ceramic structure or mineral source selected to modulate biosynthesis and mineralization of chondrocytes. | 03-03-2016 |
20160058765 | METHODS FOR TREATING HAIR LOSS DISORDERS - The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor. | 03-03-2016 |
20160058764 | METHODS FOR TREATING HAIR LOSS DISORDERS - The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor. | 03-03-2016 |
20160052883 | POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE - The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension. | 02-25-2016 |
20160052789 | TECHNIQUES FOR FABRICATING DIAMOND NANOSTRUCTURES - Techniques for fabricating diamond nanostructures including application of a self-assembled hard mask to a surface of a diamond substrate to define a pattern of masked regions having a predetermined diameter surrounded by an exposed portion. The exposed portion can be vertically etched to a predetermined depth using inductively coupled plasma to form a plurality of nanoposts corresponding to the masked regions. The nanoposts can be harvested to obtain a nanostructure with a diameter corresponding to the predetermined diameter and a length corresponding to the predetermined depth. | 02-25-2016 |
20160052783 | ELECTROMECHANICAL DEVICES AND METHODS FOR FABRICATION OF THE SAME - A fabricated electromechanical device is disclosed herein. An exemplary device includes, a substrate, at least one layer of a high-transconductance material separated from the substrate by a dielectric medium, a first electrode in electrical contact with the at least one layer of a high-transconductance material and separated from the substrate by at least one first supporting member, a second electrode in electrical contact with the layer of a high-transconductance material and separated from the substrate by at least one second supporting member, where the first electrode is electrically separate from the second electrode, and a third electrode separated from the at least one layer of high-transconductance material by a dielectric medium and separated from each of the first electrode and the second electrode by a dielectric medium. | 02-25-2016 |
20160051493 | METHODS OF TREATMENT OF KERATINOCYTE-DERIVED LESIONS - Methods are provided for diagnosing and treating or preventing keratinocyte-derived lesions, e.g., SCC, (including high-risk forms), non-melanoma skin cancers (including high-risk forms), and actinic keratinosis (“AK”) by administering a therapeutically effective amount of camphor oil, camphor oil derivatives or components, and certain terpene TRPV3 agonists including 2-APB. | 02-25-2016 |
20160050909 | Reperfusion with Omega-3 Glycerides Promotes Donor Organ Protection for Transplantation - It has been discovered that isolated organs and tissues perfused/reperfused in perfusion buffer to which omega-3 glyceride oil had been added retain higher levels of function than if perfused/reperfused without the omega-3 glycerides. Isolated hearts reperfused ex vivo after induced ischemia in n-3 triglyceride perfusion emulsion maintained a normal heart rate and normal LVDP and showed a dramatically reduced frequency of arrhythmias compared to control hearts. Further, test hearts reperfused with n-3 oil triglyceride emulsion showed a decrease in creatine kinase and upregulation of certain beneficial proteins including the anti-apoptotic gene marker Bcl-2. | 02-25-2016 |
20160046686 | COMPOSITIONS AND METHODS FOR INHIBITING TUMOR CELLS BY INHIBITING THE TRANSCRIPTION FACTOR ATF5 - The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating dominant-negative ATF5 (“CP-d/n-ATF5”), wherein the CP-d/n-ATF5 is capable of inhibiting ATF5 function and/or activity. | 02-18-2016 |
20160046649 | N-ALKYL-2-PHENOXYETHANAMINES, THEIR PREPARATION AND USE - The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof. | 02-18-2016 |
20160046648 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE - The present invention provides a compound having the structure: (structurally represented) wherein R | 02-18-2016 |
20160046632 | OCTAHYDROPYRROLOPYRROLES THEIR PREPARATION AND USE - The present invention provides compounds comprising variously substituted octahydropyrrolopyrroles, their synthesis, methods of making, methods of using, compositions and formulations thereof. | 02-18-2016 |
20160041816 | SYSTEMS AND METHODS FOR MOBILE APPLICATIONS - Systems and methods for improving the performance of mobile applications are disclosed. An exemplary method can include receiving a request for the application, where the request can include target device information. The method can also determine whether the application has been cached before. If the application has not been cached, the method can download the application as a bytecode and process the bytecode into the native code format, using an Ahead-of-time compiler. The method can also provide the application in the native code format to the target device over the network. | 02-11-2016 |
20160041179 | METHOD FOR DETECTING MULTIPLE PREDETERMINED COMPOUNDS IN A SAMPLE - This invention provides methods for detecting the presence of a plurality of predetermined compounds in a sample using a plurality of tag moieties and at least one nanopore. This invention also provides methods for determining the quantity of each of a plurality of predetermined compounds in a sample using a plurality of tag moieties and at least one nanopore. This invention further provides methods for detecting interaction of at least two predetermined compounds using at least one tag moiety and at least one nanopore. | 02-11-2016 |
20160031854 | ACTIVATION OR REACTIVATION OF ACHE - Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds. | 02-04-2016 |
20160030513 | Notch1 Decoy Antagonists Protect From Obesity-Induced Insulin Resistance and Fatty Liver - The present invention provides a method of treating a subject suffering from a fatty liver disease which comprises administering to the subject a Notch decoy protein or Jagged inhibitor in an amount effective to treat the subject's fatty liver disease. | 02-04-2016 |
20160024574 | DNA SEQUENCING WITH NON-FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS AND CLEAVABLE LABEL MODIFIED NUCLEOTIDE TERMINATORS - This invention provides a process for sequencing nucleic acids using 3′ modified deoxynucleotide analogues or 3′ modified deoxyinosine triphosphate analogues, and 3′ modified dideoxynucleotide analogues having a detectable marker attached to a base thereof. | 01-28-2016 |
20160024570 | RAMAN CLUSTER TAGGED MOLECULES FOR BIOLOGICAL IMAGING - This invention provides nucleoside polyphosphate analogs each of which comprises a tag comprising a plurality of Raman-scattering moieties; compounds comprising said nucleoside polyphosphate analogs; and methods for determining the sequence of a single-stranded DNA or RNA using said nucleoside polyphosphate analogs. This invention also provides methods for detecting the interaction of a plurality of predetermined compounds, at least one of which having attached thereto a tag comprising a plurality of Raman-scattering moieties. | 01-28-2016 |
20160024007 | OCTAHYDROCYCLOPENTAPYRROLES, THEIR PREPARATION AND USE - The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatment of diseases characterized by excessive lipofuscin accumulation in the retina. | 01-28-2016 |
20160000126 | MODULATION OF SALTY TASTE PERCEPTION BY ALTERING THE FUNCTION OF BITTER- OR PKD2L1-EXPRESSING TASTE RECEPTOR CELLS - The current invention is in the field of taste and relates to methods and compositions to modulate the perceived taste of saltiness in food or food products where salty taste is desired. The methods and compositions relate to altering the activation and/or activity of the bitter-sensing taste receptor cells and the PKD2L1-expressing taste receptor cells. The invention also relates to food and food products containing agents and composition that alter the activation and/or activity of the bitter-sensing taste receptor cells and the PKD2L1-expressing taste receptor cells. | 01-07-2016 |
20160000094 | BROAD SPECTRUM NATURAL PRESERVATIVE COMPOSITION - Disclosed are combinations of organic acid, botancial extracts, essential oils and alcohol such as benzyl alcohol, phenyl ethanol, ethyl alcohol and combinations thereof, for use in compositions such as, for example, personal care formulations, preservatives for food and beverage products, disinfectants for food, topical disinfectants, surface disinfectants and oral formulations. | 01-07-2016 |
20150372159 | SYSTEMS AND METHODS FOR GRAPHENE PHOTODETECTORS - Systems and methods for graphene photodetectors are disclosed herein. A device for detecting photons can include a waveguide and at least one graphene layer disposed proximate to the waveguide. An insulating layer can be disposed between the waveguide and the graphene layer. A first electrode can be connected to a first end of the graphene layer, and a second electrode can be connected to a second end of the graphene layer opposite the first end. | 12-24-2015 |
20150369776 | SYSTEMS AND METHODS FOR SINGLE-MOLECULE DETECTION USING NANOPORES - A system and method for detecting a single-molecule using an integrated circuit which includes at least one membrane having a nanopore located between first and second reservoirs and a low-noise preamplifier having an electrode formed on the surface thereof is provided. The method includes passing a target molecule through the nanopore, and measuring a current through the nanopore to detect the presence of a biomolecular entity, if any. | 12-24-2015 |
20150368710 | CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES - This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides. | 12-24-2015 |
20150343042 | ANTI-DRUG VACCINES - The present invention relates to anti-drug vaccines based on conjugates between the drug and a non-immunogenic carrier protein. In preferred embodiments, it provides for anti-cocaine vaccines and their use to diminish the effects and/or use of cocaine in a subject. | 12-03-2015 |
20150335400 | TOOTH SCAFFOLDS - Provided is a mammalian tooth-shaped scaffold including a composition that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a tooth in the mouth of a mammal, where the tooth is absent and a tooth socket is present in the mouth at the position of the absent tooth. The method comprises implanting a scaffold having the shape of the missing tooth into the tooth socket. Additionally, a method of making a tooth scaffold is provided. The method comprises synthesizing a scaffold in the shape of a mammalian tooth and adding at least one composition that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. | 11-26-2015 |
20150329913 | Identification of a 5-Gene Expression Signature Predicting Clinical Outcome of Patients with Brain Tumors - High-grade gliomas are the most common brain tumors in humans and are essentially incurable. The defining hallmark of these high-grade gliomas is the presence within the tumor mass of highly tumorigenic cellular subpopulations that fuel tumor aggressiveness. Identification of the molecular mechanisms remains elusive. Therefore, there is a need for diagnostic markers to accurately determine the type of glioma and appropriate treatment. Gene delivery vehicles are provided that comprise an oncogene, IRES-Cre-ER cassette and a gene encoding an oligonucleotide that inhibits p53 including shp53. Methods are also provided for determining a diagnosis and for treatment of non-aggressive and aggressive gliomas. | 11-19-2015 |
20150329615 | NOTCH-BASED FUSION PROTEINS AND USES THEREOF - This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide. | 11-19-2015 |
20150323818 | APPLICATIONS OF WAVELENGTH-LOCKING USING DITHERING SIGNALS FOR MICRORING RESONATORS - A low-cost, robust method for automatically tuning a coupled resonator to match a wavelength of electromagnetic radiation emitted from an applied laser source. Dithering signals are used for automatic wavelength tuning and thermal stabilization of microring resonators. The disclosed method can be applied using low-speed analog and digital circuitry, to create a complete photonic interconnection network. The methods disclosed also automatically detect, measure, and correct for resonance shift. | 11-12-2015 |
20150320761 | NEURONAL PAIN PATHWAY - The present invention relates to the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons, which, in higher animals, is associated with persistent pain. It is based on the discovery that, following injury to an axon of a neuron, an increase in nitric oxide synthase activity results in increased nitric oxide production, which, in turn, activates guanylyl cyclase, thereby increasing levels of cGMP. Increased cGMP results in activation of protein kinase G (“PKG”), which then is retrogradely transported along the axon to the neuron cell body, where it phosphorylates MAPKerk. | 11-12-2015 |
20150315197 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE - The present invention provides a compound having the structure: | 11-05-2015 |
20150313859 | METHODS AND COMPOSTIONS FOR TREATMENT OF CANCER - The invention discloses a method of treating cancer refractory to an anticancer agent comprising administering to a cancer patient a pharmaceutical composition comprising at least one compound of Formula 1 | 11-05-2015 |
20150312463 | METHODS, SYSTEMS, AND MEDIA FOR HIGH DYNAMIC RANGE IMAGING - Systems, methods, and media for high dynamic range imaging are provided, the systems comprising: an image sensor; and a hardware processor configured to: cause the image sensor to capture first image data having a first exposure time, second image data having a second exposure time, and third image data having a third exposure time that is substantially equal to the sum of the first exposure time and the second exposure time; generate combined image data using the first image data and the second image data. | 10-29-2015 |
20150309036 | Diagnostic Markers of Indolent Prostate Cancer - A 3-gene prognostic panel has been identified that together accurately predicted the outcome of low Gleason score prostate tumors as either truly indolent or at a high risk of becoming aggressive. The 3-gene prognostic panel was validated on independent cohorts confirmed its independent prognostic value, as well as its ability to improve prognosis with currently used clinical nomograms. Expression of the 3-gene prognostic panel was determined by quantifying mRNA or protein encoded by the panel (collectively referred to as “prognostic biomarkers”). The prognostic biomarkers were discovered to be up-regulated in indolent tumors and down-regulated in aggressive forms of prostate cancer. | 10-29-2015 |
20150299344 | MACROMONOMERS FOR PREPARATION OF DEGRADABLE POLYMERS AND MODEL NETWORKS - The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product. | 10-22-2015 |
20150297313 | MARKERLESS TRACKING OF ROBOTIC SURGICAL TOOLS - Appearance learning systems, methods and computer products for three-dimensional markerless tracking of robotic surgical tools. An appearance learning approach is provided that is used to detect and track surgical robotic tools in laparoscopic sequences. By training a robust visual feature descriptor on low-level landmark features, a framework is built for fusing robot kinematics and 3D visual observations to track surgical tools over long periods of time across various types of environments. Three-dimensional tracking is enabled on multiple tools of multiple types with different overall appearances. The presently disclosed subject matter is applicable to surgical robot systems such as the da Vinci® surgical robot in both ex vivo and in vivo environments. | 10-22-2015 |
20150297188 | SYSTEMS AND METHODS FOR ESTIMATING ACOUSTIC ATTENTUATION IN A TISSUE - Systems and techniques for estimating acoustic attenuation in a tissue from time-varying radiation force information generated through the application of acoustic energy to the tissue from at least first and second focal depths are provided. An exemplary technique includes acquiring first signals representing oscillatory motion of the tissue in response to the radiation force proximate the first focal depth, and acquiring second signals representing oscillatory motion of the tissue in response to the radiation force proximate the second focal depth. The technique further includes estimating the oscillatory motion of the tissue from each of the first and second signals, and estimating the acoustic attenuation in the tissue from the estimated oscillatory motion of the tissue from the first and second signals. | 10-22-2015 |
20150289840 | SYSTEMS AND METHODS FOR MECHANICAL MAPPING OF CARDIAC RHYTHM - Techniques for mapping behavior of a heart include acquiring a series of two or more images of the heart. The series of images is taken at one or more pixel locations, each pixel location corresponding to a region of the heart. Image data corresponding to the pixel locations can be obtained, and a periodicity of the image data measured for each of the pixel locations over the series of images. The periodicity corresponds to an electromechanical signal of the heart in the region corresponding to the measured one or more pixel locations. | 10-15-2015 |
20150286785 | SYSTEMS, METHODS, AND DEVICES FOR IMAGE RECONSTRUCTION USING COMBINED PDE-CONSTRAINED AND SIMPLIFIED SPHERICAL HARMONICS ALGORITHM - Systems, methods, and devices for image reconstruction using combined PDE-constrained and simplified spherical harmonics (SPN) algorithm are presented herein. SPN equations can be used as the forward model in diffuse optical tomography (DOT) and employed in a PDE-constrained reduced space sequential quadratic programming (rSQP) optimization method to reconstruct spatially distributed optical properties, such as absorption, scattering, fat, oxygenated hemoglobin, de-oxygenated hemoglobin, fluorescent concentration, quantum yield, etc. The SPN algorithm with the PDE-constrained rSQP optimization method allows for DOT imaging that uses significantly less computational resources (e.g., time and random-access memory (RAM)) than methods employing the equation of radiative transfer (ERT). The techniques disclosed herein allow for more expeditious image processing as well as the potential for clinical diagnosis using DOT imaging. Diagnosis can be performed by a computer-aided diagnosis (CAD) system, which can provide clinically relevant analysis and interaction shortly after patient imaging. | 10-08-2015 |
20150285751 | MEMS-BASED ISOTHERMAL TITRATION CALORIMETRY - A microelectromechanical systems-based calorimetric device includes first and second micromixers and first and second thermally-isolated microchambers. A first solution including a sample and a reagent is introduced to the first microchamber via the first micromixer, and a second solution including a sample and a buffer is introduced to the second microchamber via the second micromixer. A thermopile measures the differential temperature between the first microchamber and the second microchamber and outputs a voltage representative of the difference. The output voltage can be used to calculate reaction parameters. | 10-08-2015 |
20150276757 | WHEAT PROTEOMIC MICROARRAY FOR BIOMARKER DISCOVERY - This invention pertains to the preparation of arrays containing the proteome of wheat, including gluten and non-gluten proteins. Antibodies to wheat gluten have been shown to be elevated, not only in celiac disease and wheat allergy, but also in neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and autism. The array would be able to detect specific patterns of antibody reactivity to gluten proteins that are unique to each disease and which may have utility as biomarkers. The array may also have use in detecting patterns of cross-reactive autoantibodies in other disorders. | 10-01-2015 |
20150272921 | Use of an Omega-3 Lipid-Based Emulsion Following Ischemic Injury to Provide Protection and Recovery in Human Organs - The present invention provides methods of limiting cell death resulting from hypoxic-ischemia comprising, administering an omega-3 lipid-based emulsion after a hypoxic-ischemia insult. The omega-3 lipid-based emulsion preferably comprises at least 20% omega-3 oil, by weight, and wherein the omega-3 oil comprises at least 20% omega-3 triglycerides and/or diglycerides, and wherein fatty acids of the omega-3 trigylceride and/or diglycerides comprise at least 40% EPA and/or DHA. The present invention also provides novel fish-oil compositions for administration after an ischemic insult to limit cell death in the organ that underwent an ischemic event. | 10-01-2015 |
20150270952 | SYSTEM AND METHODS FOR SILENCING HARDWARE BACKDOORS - Methods for preventing activation of hardware backdoors installed in a digital circuit, the digital circuit comprising one or more hardware units to be protected. A timer is repeatedly initiated for a period less than a validation epoch, and the hardware units are reset upon expiration of the timer to prevent activation of a time-based backdoor. Data being sent to the hardware unit is encrypted in an encryption element to render it unrecognizable to a single-shot cheat code hardware backdoor present in the hardware unit. The instructions being sent to the hardware unit are reordered randomly or pseudo-randomly, with determined sequential restraints, using an reordering element, to render an activation instruction sequence embedded in the instructions unrecognizable to a sequence cheat code hardware backdoor present in the hardware unit. | 09-24-2015 |
20150265666 | BOTANICAL ANTIMICROBIAL COMPOSITIONS - Disclosed herein are antimicrobial compositions comprising mixtures of botanical extracts, synthetic antimicrobial agents and essential oils which do not rely solely upon alcohol to produce their antimicrobial effects. | 09-24-2015 |
20150265346 | APPARATUS, METHOD, AND SYSTEM FOR SELECTIVELY EFFECTING AND/OR KILLING BACTERIA - Certain exemplary embodiments of the present disclosure can provide an apparatus and method for generating at least one radiation can be provided. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range can be provided. | 09-24-2015 |
20150265274 | Endovascular Flexible Stapling Device - A flexible endovascular stapling device is used for an intravascular procedure to repair a defect, such as a foramen ovale closure. The procedure is designed to avoid open heart surgery by permitting the closure of the defect utilizing a stapling means which is positioned by using a flexible/shaft/guidewire system. Also, in a staple useful for surgical application in a body, there is an improvement wherein the distal portion of a filament having proximal and distal portions is fixedly attached to the staple. | 09-24-2015 |
20150265273 | Endovascular Flexible Stapling Device - The present invention concerns a flexible stapling device ( | 09-24-2015 |
20150263190 | INTEGRATED THERMAL STABILIZATION OF A MICRORING RESONATR - Embodiments of the present disclosure provide devices and methods involving the thermal stabilization of microring resonators, such as microring modulators. Power is measured via an on-chip photodetector integrated with a drop port of the microring resonator, providing a local measurement of average power. This average power is employed as a feedback measure to actively control a heater that is integrated with the microring resonator, in order to stabilize the resonant wavelength of the microring resonator in the presence of thermal fluctuations. Employing such a system, a microring modulator can maintain error-free performance under thermal fluctuations that would normally render it inoperable. | 09-17-2015 |
20150258170 | Diagnosis and Treatment of SMA and SMN Deficiency - The present invention provides for methods for diagnosing and treating a motor neuron disease. More specifically, the present invention offers new methods for diagnosing and treating SMA or SMN deficiencies and monitoring treatment. It is possible to identify a subject having a symptom of the disease, and then administer to the subject a therapeutically effective amount of one or more proteins or a gene delivery vehicle or pharmaceutical composition comprising one or more genes selected from the group consisting of Transmembrane protein 41B (Stasimon), Chromosome 19 open reading frame 54 (Rashomon), Tetraspanin 31, Poly (ADP-ribose) polymerase family member 1, Histidyl-tRNA synthetase-like, Chloride channel 7, and Nucleolar protein 1. | 09-17-2015 |
20150255876 | SYSTEMS AND METHODS FOR ADJUSTABLE ABERRATION LENS - Adjustable aberration lens for focusing a light wave in optical communication with the lens therethrough, the light wave having a plurality of frequency components including a lower frequency component and a higher frequency component, includes a metamaterial having a plurality of zones, each zone configured to shift a phase of the light wave by a phase shift amount, wherein a combined phase shift amount of the plurality of zones focuses the light wave such that the higher frequency component has a focal length greater than or equal to the lower frequency component. Methods for focusing a light wave are also provided. | 09-10-2015 |
20150247124 | Generation of Airway and Lung Progenitors and Epithelial Cells and Three-Dimensional Anterior Foregut Spheres - Embodiments of the present invention are directed to various methods for generating airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres, and to populations of cells made using the methods. The airway and lung progenitors and epithelial cells can be used as a model to study diseases that primarily affect airway epithelial cells, and to study human lung development. Methods are also provided for drug screening. Anterior foregut spheres can be used as a model for lung fibrosis. | 09-03-2015 |
20150220832 | SYSTEMS AND METHODS FOR IDENTIFICATION OF SPIKE-PROCESSING CIRCUITS - Techniques for the identification of a spike-processing circuit are provided. An exemplary method includes receiving spike trains corresponding to a circuit input over a time period, and selecting a number of spikes for each of input spike trains over a predetermined time window. Each of the selected spikes can be replaced with a sampled reproducing kernel to obtain a plurality of signals, and each obtained signal can correspond to one of the input spike trains. Each of the obtained signals can be passed through a plurality of receptive fields or filters to obtain an aggregate filter output signal. The filter output signal can be encoded into an output spike train, and the output spike train can correspond to a response of the circuit to the plurality of input spike trains. | 08-06-2015 |
20150219667 | PRE-TRANSPLANT IgG REACTIVITY TO APOPTOTIC CELLS CORRELATES WITH LATE KIDNEY ALLOGRAFT LOSS - It has been discovered that significantly elevated levels of anti-apoptotic cell IgG is an important contributor to and predictor of late graft rejection. Kaplan-Meier survival analysis revealed that patients with high pre-transplant IgG and post-transplant reactivity to apoptotic cells had a significantly increased rate of late graft loss that was apparent after approximately 1 year post-transplant. This association between pre-transplant IgG reactivity to apoptotic cells and graft loss was still significant after excluding patients with high reactivity to HLA, and it was almost exclusively mediated by IgG1 and IgG3 with complement fixing and activating properties. The association between elevated levels of anti-apoptotic cell IgG antibodies and late transplant rejection forms a basis for diagnosing and treating patients at high risk of late transplant rejection. | 08-06-2015 |
20150216439 | SYSTEMS AND METHODS FOR IDENTIFYING AND TRACKING NEURAL CORRELATES OF BASEBALL PITCH TRAJECTORIES - Methods and systems for evaluating a subject's response to a task related to a stimulus include a brain activity sensor, such as an EEG sensor, for measuring neural data generated by the subject in response to the visual stimulus. One or more neural discriminators can be calculated based on the neural data. In order to generate one or more neural discriminators, two or more task conditions can be selected for discrimination. The subject's performance can be evaluated based on the one or more neural discriminators. Feedback can be provided to the subject to assist in achieving better performance. | 08-06-2015 |
20150214384 | SYSTEMS AND METHODS FOR CMOS-INTEGRATED JUNCTION FIELD EFFECT TRANSISTORS FOR DENSE AND LOW-NOISE BIOELECTRONIC PLATFORMS - A complementary metal oxide semiconductor (CMOS)-integrated junction field effect transistor (JFET) has reduced scale and reduced noise. An exemplary JFET has a substrate layer of one dopant type with a gate layer of that dopant type disposed on the substrate, a depletion channel of a second dopant type disposed on the first gate layer, and a second gate layer of the first dopant type disposed on the depletion channel and proximate a surface of the transistor. The second gate layer can separate the depletion channel from the surface, and the depletion channel separates the first gate layer from the second gate layer. | 07-30-2015 |
20150213633 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING A PANORAMIC CONE BEAM COMPUTED TOMOGRAPHY (CBCT) - Exemplary devices, procedures and computer-readable mediums for providing a projection image associated with at least one target. The projection image can be formed from a plurality of locations of a source arrangement. At each source location, a plurality of panoramic projection images associated with a target can be acquired. At least two of the panoramic projection images can be obtained at view angles which are different from one another. These panoramic projection images can be stitched together or otherwise combined. A resulting image can then be generated using a computed tomography procedure based on the stitched or combined projection images that are generated at the plurality of location. | 07-30-2015 |
20150208304 | Methods, Media, and Devices for Moving a Connection from One Point of Access to Another Point of Access - Systems, methods, media, and devices for providing cooperation among digital processing devices in wireless networks are provided. In some embodiments, methods for moving a connection from one point of access to another point of access are provided, sending a request for information from a first mobile node to at least one other node, wherein the request for information contains first information identifying at least one point of access; receiving a response containing second information identifying at least one point of access from the at least one other node; and establishing a connection between the first mobile node and a point of access identified in the second information. In some embodiments, devices that can move a connection from one point of access to another point of access are provided. | 07-23-2015 |
20150202234 | Injectable Brown Adipose Microtissues for Treatment and Prevention of Obesity and Diabetes - Provided are methods, pharmaceutical compositions, and kits for treatment of a metabolic condition, including obesity and type 2 diabetes by administration of a therapeutically effective amount of a cell or tissue preparation such as brown adipose microtissues to a subject, where the microtissues comprise adipose stem cells and endothelial cells. Modified approaches to creating brown adipose tissue involve differentiation of explanted white adipose tissue rather than isolation and expansion of adipose stems cells or endothelial cells and formation and differentiation of 3D cell aggregates. | 07-23-2015 |
20150194991 | GRAPHENE RESONATOR BASED MIXER-FIRST RECEIVER ON CMOS FOR DIGITALLY CONTROLLED AND WIDELY TUNABLE RF INTERFACE - A radio frequency (RF) receiver including a baseband circuitry. The baseband circuitry can include a graphene nano-electro-mechanical (GNEMS) based system, a receiver, and a front-end mixer. The GNEMS based system can include a source, a drain, a gate and a nano-scale suspended graphene resonator. The graphene resonator can be suspended between the source and the drain. The receiver circuitry can be disposed on the baseband and configured to receive an RF signal. The front-end mixer can be disposed between the GNEMS based system and the receiver circuitry. The baseband circuitry can be configured such that an incoming signal sees frequency selective impedance at the receiver circuitry. | 07-09-2015 |
20150192596 | SYSTEMS AND METHODS FOR DETECTION OF ELECTRIC FIELDS, ION EXCHANGE, AND PH USING SPECTRAL SHIFT IN DIAMOND COLOR CENTERS - Techniques for detection of electric and magnetic fields, ion exchange, and pH using spectral shift in diamond color centers are disclosed. In one aspect of the disclosed subject matter, a method to detect a change of an electric field or electrochemical parameter in a solution can include introducing at least one diamond structure, including a color center below a surface of thereof, into the solution. | 07-09-2015 |
20150183834 | Filoviral Immunosuppressive Peptides - The invention provides a region of strong secondary structure conservation between the C-terminus domain of the envelope glycoprotein of filoviruses and an immunosuppressive domain found in retroviral envelope glycoproteins. The invention provides filoviral peptides and modified derivatives thereof with strong immunosuppressive bioactivity. The invention further provides methods for treatment of autoimmune disorders by administering the immunosuppressive peptide. The invention also provides methods for the identification of therapeutic agents that modulate the immunosuppressive activity of the peptides. Antibodies against the inventive peptides and the modified derivatives thereof are also provided. Furthermore, the invention provides methods for treatment of filoviral infection by administering compositions comprising the antibodies and/or the therapeutic agents that modulate the immunosuppressive activity of the inventive peptides. | 07-02-2015 |
20150181596 | METHOD, COMPUTER-READABLE STORAGE DEVICE, AND APPARATUS FOR ALLOCATING TIMESLOTS ON CHANNELS IN A WIRELESS NETWORK - A method, computer-readable storage device, and apparatus for allocating a plurality of timeslots of each channel of a plurality of channels in a wireless network are disclosed. For example, the method determines a location and a velocity for each user endpoint device of a plurality of user endpoint devices, estimates a future data rate for each user endpoint device at the location, estimates future timeslot allocations of each channel of the plurality of channels in the wireless network in accordance with the future data rate that is predicted for each user endpoint device, and allocates each timeslot of the plurality of timeslots of each channel of the plurality of channels in the wireless network to a user endpoint device of the plurality of user endpoint devices in accordance with the future timeslot allocations that are estimated for each channel. | 06-25-2015 |
20150180895 | APPARATUS METHOD AND MEDIUM FOR TRACING THE ORIGIN OF NETWORK TRANSMISSIONS USING N-GRAM DISTRIBUTION OF DATA - A method, apparatus, and medium are provided for tracing the origin of network transmissions. Connection records are maintained at computer system for storing source and destination addresses. The connection records also maintain a statistical distribution of data corresponding to the data payload being transmitted. The statistical distribution can be compared to that of the connection records in order to identify the sender. The location of the sender can subsequently be determined from the source address stored in the connection record. The process can be repeated multiple times until the location of the original sender has been traced. | 06-25-2015 |
20150178865 | TOTAL PROPERTY OPTIMIZATION SYSTEM FOR ENERGY EFFICIENCY AND SMART BUILDINGS - Techniques for managing one or more buildings, including collecting historical building data, real-time building data, historical exogenous data, and real-time exogenous data and receiving the collected data at an adaptive stochastic controller. The adaptive stochastic controller can generate at least one predicted condition with a predictive model. The adaptive stochastic controller can generate one or more executable recommendations based on at least the predicted conditions and one or more performance measurements corresponding to the executable recommendations. | 06-25-2015 |
20150157979 | Methods and Systems for Synthesizing Iron-Based Materials and Sequestering Carbon Dioxide - Methods and systems for sequestering carbon dioxide and generating hydrogen are disclosed. In some embodiments, the methods include the following: dissolving an iron based material that includes a carbonate-forming element into a solution including the carbonate-forming element and iron; increasing a pH of the solution to cause precipitation of iron oxide from the solution thereby generating a first source of Fe | 06-11-2015 |
20150156122 | UNIFIED NETWORKING SYSTEM AND DEVICE FOR HETEROGENEOUS MOBILE ENVIRONMENTS - Method for unified networking for a device in heterogeneous mobile environments includes maintaining and monitoring active network interfaces, managing the location of the device, managing network access security, enabling disruption tolerance support for applications, enabling service sharing and session mobility, managing system parameters for one or more active application sessions, managing storage functionality in one or more memory devices, and maintaining a mapping for one or more flows corresponding to the one or more active application sessions, maintaining one or more policies, and performing flow control decisions based upon the policies using a policy engine. The method can also include monitoring for network events, evaluating whether to perform a handover based upon policies, and providing seamless secure handovers in a heterogeneous mobile environment. A device, non-transitory computer-readable medium, and a system for unified networking are also provided. | 06-04-2015 |
20150153716 | DECISION SUPPORT CONTROL CENTERS - The disclosed subject matter relates to an integrated decision support “cockpit” or control center for displaying, analyzing, and/or responding to, various events and contingencies that can occur within an electrical grid. | 06-04-2015 |
20150153364 | BIOMARKERS FOR TANGLE-PREDOMINANT DEMENTIA - This invention relates to the field of screening for, identifying, and diagnosing tangle-predominant dementia (TPD). Specifically, this invention provides various biomarkers for this disease, and methods of using these biomarkers to correctly subclassify patients with Alzheimer's-type dementia by differentiating TPD patients from those with classical Alzheimer's disease (AD), as well as prodromal AD, and mild cognitive impairment due to AD. | 06-04-2015 |
20150150943 | USE OF SDF-1 TO IMPROVE ISCHEMIC MYOCARDIAL FUNCTION - A method is provided for increasing trafficking of endothelial progenitor cells to an ischemic myocardium in a subject's heart comprising administering to the subject's heart an amount of Stromal-Derived Factor-1 (SDF-1). | 06-04-2015 |
20150148302 | Peptide Inhibitors of Caspase 2 Activation - The present invention relates to compositions, including membrane permeable complexes, comprising a Caspase 2 activation inhibitory peptide having the amino acid sequence AFDAFC as well as methods of using the same for the treatment of neurodegenerative conditions associated with apoptosis in the central nervous system, such as Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, amyotrophic lateral sclerosis, Huntington's chorea, and Creutzfeld-Jacob disease. | 05-28-2015 |
20150148240 | UNIVERSAL METHYLATION PROFILING METHODS - This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns. | 05-28-2015 |
20150137793 | SYSTEMS AND METHODS FOR PRECISION OPTICAL IMAGING OF ELECTRICAL CURRENTS AND TEMPERATURE IN INTEGRATED CIRCUITS - Systems and methods for precision optical imaging of electrical currents and temperature in integrated circuits are disclosed herein. In one aspect of the disclosed subject matter, a method for detecting a characteristic of an integrated circuit can include depositing at least one diamond structure, having at least one color center therein, onto a side of the integrated circuit. | 05-21-2015 |
20150129209 | Methods and Systems for Causing Reaction Driven Cracking in Subsurface Rock Formations - Methods and systems for causing reaction driven cracking in subsurface rock formations are disclosed. In some embodiments, the methods include the following: drilling one or more holes in a substantially porous subsurface rock formation, the one or more holes in fluid communication with pores in the subsurface rock formation; injecting in the pores via at least one of the holes one or more fluids, wherein the one or more fluids include a gas; and chemically reacting the one or more fluids within the pores thereby causing cracking in the substantially porous subsurface rock formation. | 05-14-2015 |
20150126576 | NEURONAL PAIN PATHWAY MODULATORS - The present invention relates to compounds that may be used to inhibit activation of protein kinase G (“PKG”). It is based, at least in part, on the discovery of the tertiary structure of PKG and the identification of molecules that either bind to the active site of PKG and/or are analogs of balanol. | 05-07-2015 |
20150126494 | NON-RETINOID ANTAGONISTS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND STARGARDT DISEASE - A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in mammals afflicted therewith, comprising administering to the mammal an effective amount of a non-retinoid antagonist compound or a pharmaceutically acceptable salt thereof. | 05-07-2015 |
20150118275 | BIO-FILM RESISTANT SURFACES - The present invention relates to methods and compositions for rendering a surface resistant to bio-film formation by a combination of an alkanediol and an antimicrobial agent (and, optionally, an organic hydroxy acid). The invention provides for compositions which may be used to render surfaces bio-film resistant, articles having bio-film resistant surfaces, and methods for their preparation. The present invention may be advantageously applied to medical articles as well as articles used in non-medical contexts, such as child care or food preparation. | 04-30-2015 |
20150111759 | METHOD OF PREPARATION OF NANOPORE AND USES THEREOF - This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule. | 04-23-2015 |
20150110714 | Diagnosis and Treatment of Cancer Expressing ILT3 or ILT3 Ligand - The present invention relates to methods of using the expression of ILTL3 ligand or ILT3 on certain types of cancer cells as a diagnostic tool. Methods are provided for treating ILT3-ligand expressing cancers, such as T-cell acute lymphoblastic leukemia (T-cell acute lymphoblastic leukemia), for example by administering ILT3, the extracellular domain of ILT3 or ILT3Fc conjugated to a cytotoxic agent to kill the targeted cancer cell. Other methods are provided for treating cancers that express ILT3 on their surface, such as monocytic forms of AML, for example by administering anti-ILT3 antibodies conjugated to a cytotoxic agent. | 04-23-2015 |
20150105272 | BIOMOLECULAR EVENTS IN CANCER REVEALED BY ATTRACTOR METAGENES - The present invention is directed to compositions and methods for the independent and unconstrained identification of attractor metagenes as surrogates of pure biomolecular events as well as the use of such attractor metagenes in performing medical diagnosis, prognosis, and developing appropriate therapeutic regimes. | 04-16-2015 |
20150100121 | BIOMIMMETIC NANOFIBER SCAFFOLD FOR SOFT TISSUE AND SOFT TISSUE-TO-BONE REPAIR, AUGMENTATION AND REPLACEMENT - An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering. | 04-09-2015 |
20150095040 | OBJECT-BASED AUDIO-VISUAL TERMINAL AND BITSTREAM STRUCTURE - As information to be processed at an object-based video or audio-visual (AV) terminal, an object-oriented bitstream includes objects, composition information, and scene demarcation information. Such bitstream structure allows on-line editing, e.g. cut and paste, insertion/deletion, grouping, and special effects. In the interest of ease of editing, AV objects and their composition information are transmitted or accessed on separate logical channels (LCs). Objects which have a lifetime in the decoder beyond their initial presentation time are cached for reuse until a selected expiration time. The system includes a de-multiplexer, a controller which controls the operation of the AV terminal, input buffers, AV objects decoders, buffers for decoded data, a composer, a display, and an object cache. | 04-02-2015 |
20150093849 | SYSTEMS AND METHODS FOR SINGLE-MOLECULE NUCLEIC-ACID ASSAY PLATFORMS - Integrated circuits for a single-molecule nucleic-acid assay platform, and methods for making such circuits are disclosed. In one example, a method includes transferring one or more carbon nanotubes to a complementary metal-oxide semiconductor (CMOS) substrate, and forming a pair of post-processed electrodes on the substrate proximate opposing ends of the one or more carbon nanotubes. | 04-02-2015 |
20150090588 | SYSTEMS AND METHODS FOR BIOLOGICAL ION CHANNEL INTERFACES - Method for interfacing an integrated circuit with a biological ion channel, the integrated circuit being at least partially disposed within an electrolytic solution and including an amplifier and one or more electrodes on a surface thereof, includes forming one or more microwells proximate the one or more electrodes, applying a lipid membrane over the integrated circuit proximate the microwells, and placing a further electrode in the electrolytic solution proximate the lipid membrane on a side opposite the integrated circuit. A biological ion channel interface is also provided. | 04-02-2015 |
20150087716 | ANTIMICROBIAL MEDICAL DEVICES CONTAINING CHLORHEXIDINE FREE BASE AND SALT - The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1. | 03-26-2015 |
20150080232 | DNA SEQUENCING BY SYNTHESIS USING RAMAN AND INFRARED SPECTROSCOPY DETECTION - This invention provides nucleoside triphosphate analogues having the structure: | 03-19-2015 |
20150078641 | Techniques for Segmentation of Lymph Nodes, Lung Lesions and Other Solid or Part-Solid Objects - Techniques for segmentation include determining an edge of voxels in a range associated with a target object. A center voxel is determined. Target size is determined based on the center voxel. In some embodiments, edges near the center are suppressed, markers are determined based on the center, and an initial boundary is determined using a watershed transform. Some embodiments include determining multiple rays originating at the center in 3D, and determining adjacent rays for each. In some embodiments, a 2D field of amplitudes is determined on a first dimension for distance along a ray and a second dimension for successive rays in order. An initial boundary is determined based on a path of minimum cost to connect each ray. In some embodiments, active contouring is performed using a novel term to refine the initial boundary. In some embodiments, boundaries of part-solid target objects are refined using Markov models. | 03-19-2015 |
20150078640 | Methods and Systems for Segmentation of Organs and Tumors and Objects - Techniques for segmentation of organs and tumors and cells in image data include revising a position of a boundary by evaluating an evolution equation that includes differences of amplitude values for voxels on the boundary from a statistical metric of amplitude of voxels inside, and from a statistical metric of amplitude of voxels outside, for a limited region that lies within a distance r of the boundary. The distance r is small compared to a perimeter of the first boundary. Some techniques include determining a revised position of multiple boundaries by evaluating an evolution equation that includes differences in a first topographical distance from a first marker and a second topographical distance from a second marker for each voxel on the boundary, and also includes at least one other term related to boundary detection. | 03-19-2015 |
20150073396 | APPARATUS, METHOD, AND SYSTEM FOR SELECTIVELY EFFECTING AND/OR KILLING BACTERIA - Certain exemplary embodiments of the present disclosure can provide an apparatus and method for generating at least one radiation can be provided. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range can be provided. | 03-12-2015 |
20150071934 | Methods For Regulating Hair Growth Disorders - The invention provides for methods for treating a hair loss disorder in a subject by administering a FGF13 inhibitor. The invention further provides for methods for treating a hair growth disorder in a subject by administering a FGF13 activator. | 03-12-2015 |
20150064234 | 4-AMINOPYRIDINE AS A THERAPEUTIC AGENT FOR SPINAL MUSCULAR ATROPHY - It has been discovered that pharmacological inhibition of K+ channels (using the FDA-approved broad-spectrum K+ channel antagonist 4-AP) positively benefitted smn mutant phenotypes, a result that is consistent with the defective excitability of motor circuits by their interneuron or sensory neuron inputs being a critical consequence of SMN depletion. Based on these observations, certain embodiments of the invention are directed to methods of treatment of SMA by administering therapeutically effective amounts of one or more potassium channel antagonists, including 4-aminopyridine, 4-(dimethylamino)pyridine, 4-(methylamino)pyridine, and 4-(aminomethyl)pyridine. Other embodiments are directed to new pharmaceutical formulations comprising two or more potassium channel antagonists. | 03-05-2015 |
20150058826 | SYSTEMS AND METHODS FOR EFFICIENTLY AND EFFECTIVELY DETECTING MOBILE APP BUGS - The disclosed subject matter provides techniques for detecting and diagnosing mobile app bugs. An approximate execution mode screens for potential bugs, which can expose bugs but can generate false positives. From the generated bug reports, certain bugs can be automatically validated and false positives pruned, reducing the need for manual inspection. | 02-26-2015 |
20150057320 | TRANSTHYRETIN LIGANDS CAPABLE OF INHIBITING RETINOL-DEPENDENT RBP4-TTR INTERACTION FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION, STARGARDT DISEASE, AND OTHER RETINAL DISEASE CHARACTERIZED BY EXCESSIVE LIPOFUSCIN ACCUMULATION - A method for treating a disease characterized by excessive lipofuscin accumulation in the retina of a mammal afflicted therewith comprising administering to the mammal an effective amount of a transthyretin (TTR) ligand. | 02-26-2015 |
20150056699 | SMALL MOLECULE INDUCERS OF GDNF AS POTENTIAL NEW THERAPEUTICS FOR NEUROPSYCHIATRIC DISORDERS - This invention provides a compound having the structure | 02-26-2015 |
20150056161 | REGENERATION OF ENDOGENOUS MYOCARDIAL TISSUE - This invention provides a method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject a composition comprising an amount of a human stromal derived factor-1 and an amount of a human granulocyte-colony stimulating factor, the composition being administered in an amount effective to cause proliferation of cardiomyocytes within the subject's heart so as to thereby treat the disorder. This invention also provides a method of treating a subject suffering from a disorder of a tissue involving loss and/or apoptosis of cells of the tissue which comprises administering to the subject a composition comprising an amount of an agent which induces phosphorylation and/or activation of protein kinase B, or an agent which induces phosphorylation and/or activation of an extracellular signal-regulated protein kinase, or an agent which induces activation of CXCR4. | 02-26-2015 |
20150051452 | APPARATUS, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR TRANSFORM ANALYSIS OF BIOMEDICAL DATA - Exemplary method, computer-readable medium and system can be provided for generating at least one information associated with at least one signal and/or data received from at least one structure. For example, it is possible to determine at least one basis based on a combination of a plurality of portions of the signal(s) and/or the data. It is also possible to generate the information(s) as a function of the basis. | 02-19-2015 |
20150045724 | SYSTEMS AND METHODS FOR TARGETED DRUG DELIVERY - Techniques for opening a target tissue using nanodroplets are provided. An exemplary method can include targeting a region of tissue for opening, delivering a plurality of nanodroplets to the region, and applying an ultrasound beam at the region such that the nanodroplets cavitate, or convert to microbubbles that cavitate, thereby causing the target tissue to open. | 02-12-2015 |
20150044672 | STREPTAVIDIN COMPLEXES AND USES THEREOF - Provided are compositions including a streptavidin composition in which a plurality of biotin binding sites are blocked by tethered biotins. Also provided are methods of using such compositions, including cell imaging, nucleic acid analysis or detection, or biotinylation quantification. | 02-12-2015 |
20150042400 | SYSTEMS AND METHODS FOR INTEGRATED VOLTAGE REGULATORS - A multi-chip module (MCM) is disclosed, which in some embodiments can include a packaging substrate, an interposer coupled to the substrate and having a power converter coupled to one or more vias, and a CMOS integrated circuit comprising one or more connecters aligned with and disposed proximate to the one or more vias to electrically couple the interposer to the integrated circuit. Methods of forming a voltage regulator on an interposer of a multi-chip module (MCM) are also provided. | 02-12-2015 |
20150038791 | Device For Use In A Surgical Procedure On An Human Eye - Presented is a device for use in a surgical procedure on an eye. The device includes an elongated member that includes a first elongated portion, a second elongated portion, and hook portion. The first elongated portion includes a proximal end and a distal end. The second elongated portion includes a proximal end and a distal end. The proximal end of the second elongated portion is coupled to the distal end of the first elongated portion. The second elongated portion extends from the first elongated portion at an angle to the longitudinal axis of the first elongated portion. The hook portion includes a proximal end and a distal end. The proximal end of the hook portion is coupled to the distal end of the second elongated member. | 02-05-2015 |
20150037788 | DNA SEQUENCING BY NANOPORE USING MODIFIED NUCLEOTIDES - This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides. | 02-05-2015 |
20150037382 | MICROSPHERE SKIN TREATMENT - This application provides a microsphere suitable for tissue engineering that comprises connective tissue growth factor (CTGF). Also provided is a matrix, material or scaffold suitable for tissue engineering that comprises connective tissue growth factor (CTGF) and basic fibroblast growth factor (bFGF). Additionally, methods of treating skin of a human are provided. The methods comprise administering to the skin microspheres comprising a growth factor that increases fibroblast proliferation or collagen, elastin, or glycosaminoglycan synthesis. Further provided are the use of the above microspheres for the treatment of the skin of a human. Additionally, this application proves the use of the above microsphere for the manufacture of a medicament for the treatment of the skin of a human. | 02-05-2015 |
20150030619 | Activation and Expansion of T Cell Subsets Using Biocompatible Solid Substrates with Tunable Rigidity - The present invention provides compositions and methods for activation and expansion of T cells using a biocompatible solid substrate with tunable rigidity. Rigidity of a substrate is an important parameter that can be used to control the overall expansion and differentiation of T cells. | 01-29-2015 |
20150024063 | MULTI-PHASED, BIODEGRADABLE AND OESTEOINTEGRATIVE COMPOSITE SCAFFOLD FOR BIOLOGICAL FIXATION OF MUSCULOSKELETAL SOFT TISSUE TO BONE - Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The microspheres are layered to have a gradient of microsphere sizes and/or compositions. The scaffold provides a functional interface between multiple tissue types. | 01-22-2015 |
20150023840 | Functionalized Surfaces and Methods Related Thereto - The disclosed subject matter provides a nanoaperture having a bottom surface and a side wall comprising gold. A surface of the side wall is passivated with a first functional molecule comprising polyethylene glycol. The bottom surface of the nanoaperture can be functionalized with at least one second molecule comprising polyethylene glycol, for example, a silane-PEG molecule. The second molecule can further include a moiety, such as biotin, which is capable of binding a target biomolecule, which in turn can bind to a biomolecule of interest for single molecule fluorescence imaging analysis. Fabrication techniques of the nanoaperture are also provided. | 01-22-2015 |
20150012224 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING BODY-CONFORMING ANIMAL BED, CALIBRATION CELL AND ORGAN PROBABILITY MAP FOR QUANTITATIVE OPTICAL IMAGING OF ANATOMICAL STRUCTURES - Exemplary systems, methods and computer accessible mediums which can determine quantitative information of a tissue(s) can be provided, which can include receiving optical information regarding the tissue(s), and determining the quantitative information of the tissue(s), in real time and during the receipt of the optical information, using an atlas. The tissue(s) can be part of a mouse, and the quantitative information can be an in-vivo count of cells or bacteria in the tissue(s). The quantitative information can be determined by co-registering the in-vivo count to the atlas. The optical information can be generated using a mirror gantry(s) so as to simultaneously image at least two opposing views of the tissue(s). | 01-08-2015 |
20150011629 | BIOACTIVE DEPSIDE AND ANTHOCYANIN COMPOUNDS, COMPOSITIONS, AND METHODS OF USE - Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CH | 01-08-2015 |
20150010926 | METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY HCG ASSAY - The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample. | 01-08-2015 |
20150010222 | SYSTEMS AND METHODS OF HIGH FRAME RATE STREAMING FOR TREATMENT MONITORING - Systems and techniques of treatment monitoring include acquiring channel data from each of a plurality of channels of a signal array over a plurality of frames, determining a reconstruction matrix based on a reconstruction operation to be performed on the channel data, applying the reconstruction matrix to the channel data to obtain reconstructed channel data, estimating displacement data representing displacement of an object over the frames from the reconstructed channel data; determining a conversion matrix based on a conversion operation to be performed on the reconstructed channel data, and applying the conversion matrix to the reconstructed channel data to obtain a displacement map. | 01-08-2015 |
20140377743 | CHEMICALLY CLEAVABLE 3'-O-ALLYL-DNTP-ALLYL-FLUOROPHORE FLUORESCENT NUCLEOTIDE ANALOGUES AND RELATED METHODS - This invention provides a nucleotide analogue comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety bound to the 3′-oxygen of the deoxyribose and (iv) a fluorophore bound to the base via an allyl linker, and methods of nucleic acid sequencing employing the nucleotide analogue. | 12-25-2014 |
20140368607 | Systems And Methods For Panoramic Imaging - Systems and methods for panoramic imaging are disclosed herein. An exemplary system of the disclosed subject matter for panoramic imaging includes a fisheye lens, a mirror optically coupled to the fisheye lens, and a detector for capturing light incident on the fisheye lens and reflected from the mirror. In some embodiments, the mirror is a spherical mirror. | 12-18-2014 |
20140365411 | Monitoring Health of Dynamic System Using Speaker Recognition Techniques - Monitoring health of dynamic systems includes using speaker recognition techniques. Some embodiments include determining a system-independent statistical (first) model, and determining a healthy system (second) model based on data representing vibrations of multiple healthy systems and the first model and speaker recognition techniques. Vibration data are obtained from a particular system. It is determined whether the particular system is unhealthy based on the vibration data from the particular system and the first model and the second model and speaker recognition techniques. Some embodiments include obtaining training data that represents vibrations of multiple healthy systems. A damage-sensitive parameter is based on the training data. A threshold value that separates damaged systems from healthy systems is based on the training data and the parameter. It is determined whether a particular system is healthy based on the threshold value and a value for the parameter for vibration data from the particular system. | 12-11-2014 |
20140364460 | USE OF FATOSTATIN FOR TREATING CANCER HAVING A p53 MUTATION - Fatostatin, a recently described inhibitor of SREBP activation, significantly reduces the level of mutant p53 binding to the HMG-CoA reductase gene promoter. Further, fatostatin treatment had a dramatic effect on normalizing the abnormal 3D morphology of 3 strains of breast cancer cells: MDA-468 cells, MDA-231 cells, and SKBR3 cells. The results show a functional interaction with SREBPs as being critical for mutant p53-mediated upregulation of the mevalonate pathway genes. At a clinical level, inhibition of the mevalonate pathway, either alone or in combination with other therapies, offers a novel, safe and much needed therapeutic option for tumors bearing mutant p53. | 12-11-2014 |
20140354999 | Ultracompact Fabry-Perot Array For Ultracompact Hyperspectral Imaging - Techniques for hyperspectral imaging, including a device for hyperspectral imaging including at least one tunable interferometer including a thin layer of material disposed between two or more broadband mirrors. Electrodes placed on either side of the tunable interferometer can be coupled to a voltage control circuit, and upon application of a voltage across the tunable interferometer, the distance between the mirrors can be modulated by physically altering the dimensions of the thin layer of material, which can uniformly load the broadband mirrors. Physically altering the dimensions of the thin layer of material can include one or more of deformation of a soft material, piezostrictrive actuation of a piezostrictrive material, or electrostrictive actuation of an electrostrictive material. | 12-04-2014 |
20140350337 | SYSTEMS, DEVICES, AND METHODS FOR PROVIDING INSERTABLE ROBOTIC SENSORY AND MANIPULATION PLATFORMS FOR SINGLE PORT SURGERY - The present disclosure relates to systems, devices, and methods for providing foldable, insertable robotic sensory and manipulation platforms for single port surgery. The device is referred to herein as an Insertable Robotic Effector Platform (IREP). The IREP provides a self-deployable insertable device that provides stereo visual feedback upon insertion, implements a backbone structure having a primary backbone and four secondary backbones for each of the robotic arms, and implements a radial expansion mechanism that can separate the robotic arms. All of these elements together provide an anthropomorphic endoscopic device. | 11-27-2014 |
20140349368 | POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE - The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension. | 11-27-2014 |
20140348813 | THERMOSTABILIZATION OF PROTEINS - Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition. | 11-27-2014 |
20140343424 | SYSTEM AND METHOD FOR ELECTROMECHANICAL WAVE IMAGING OF BODY STRUCTURES - A system and method for detecting electromechanical wave propagation within a body structure of a patient in a series of image frames representing movement the body structure. Image data is acquired comprising a series of image frames corresponding to the movement of a body structure. A correlation calculation is performed on the image frames to generate a displacement map representing the relative displacement between the first and second image frames. A video is generated comprising a series of displacement maps. The parameters of movement of the body structure are detected by analysis of the displacement maps. The image acquisition may detect the movement of the body structure without inducing such movement. | 11-20-2014 |
20140341424 | TOOL TRACKING DURING SURGICAL PROCEDURES - A system and method for tracking a surgical implement in a patient can have an imaging system configured to obtain sequential images of the patient, and an image recognition system coupled to the imaging system and configured to identify the surgical implement in individual images. The image recognition system can be configured to identify the surgical implement relative to the patient in one of the images based, at least in part, on an identification of the surgical implement in at least one preceding one of the sequential images, and a probabilistic analysis of individual sections of the one of the images, the sections being selected by the image recognition system based on a position of the surgical implement in the patient as identified in the at least one preceding one of the images. | 11-20-2014 |
20140339161 | FLUID COMPONENT SEPARATION DEVICES, METHODS, AND SYSTEMS - A system for ultrafiltration employs a crossflow filtration module for extracting a fraction from a sample fluid (e.g., blood) and a recirculating permeate loop to produce a concurrent permeate flow through the filtration module to maintain a positive transmembrane pressure at all points of the crossflow filter. Permeate in the recirculating loop is enriched by a processing module and stabilized by removing an enriched fraction thereof. In an embodiment, the enriched fraction is concentrated plasma that is returned to a patient. | 11-20-2014 |
20140336942 | Analyzing High Dimensional Single Cell Data Using the T-Distributed Stochastic Neighbor Embedding Algorithm - A method for mapping, graphing, and analyzing high-dimensional single cell data based on multiple parameters associated with the cell, including defining a point associated with the cell in a n-dimensional space; combining the point with other points associated with other cells to form a data set; representing the points in the data set in the n-dimensional space; projecting the points in the n-dimensional space onto a lower-dimensional map; and analyzing the features of interest in heterogeneous tissues using the lower-dimensional map. | 11-13-2014 |
20140326796 | WIRELESS AUTOMATIC TEMPERATURE CONTROL OF RADIATOR HEATING - An insulated heating-unit cover having an opening to permit air to circulate around the heating-source when a vent disposed at the top of the cover is opened, allowing heat into a space. The cover can include a heating-unit temperature sensor disposed within a space covered by the cover and a controller in wireless communication with a space temperature sensor located at a distance away from the heating-unit. The controller can be configured to operate an actuator such that the vent is open when the space temperature sensor indicates that the ambient temperature is below a set point temperature and such that the vent is closed when the ambient temperature is greater than the set point temperature. The controller can communicate with a plurality of other similar controllers and a central server to effect changes in the output of a central heating source coupled to a plurality of individual heating-units. | 11-06-2014 |
20140322696 | FUNCTIONAL RECOVERY OF HUMAN LUNGS FOR TRANSPLANTATION - The vasculature of a donor lung is perfused with a lung preserving fluid to preserve its structure. At the same time, a decellularization fluid is perfused through the airways, which strips away donor cells. The decellularized region is then seeded with pulmonary cells of the transplant recipient, which regenerate the lung. The pulmonary cells may be derived from stem cells, and the decellularization can be targeted to reduce the quantity of cells required. | 10-30-2014 |
20140321649 | METHOD AND APPARATUS FOR DISTRIBUTING A QUANTUM KEY - A method for distributing a quantum key is provided, including sending a first photon to a first receiver; sending a second photon to a second receiver, the first and second photons being a pair of time-energy entangled photons; and providing a coding scheme comprising a plurality of time bins and a plurality of frequency bins, wherein a combination of a time bin and a frequency bin corresponds to a character. | 10-30-2014 |
20140316188 | METHODS, APPARATUS, AND SYSTEMS FOR MAGNETIC STIMULATION - A coil suitable for tissue stimulation and especially for transcranial magnetic stimulation (TMS) may be used in conjunction with a pulse generator to induce electric field in the brain with less attenuation in depth compared to existing TMS coils. In an example, a coil winding is formed in a solenoid configuration around the head. Various related features, methods, and embodiments are described. | 10-23-2014 |
20140315191 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS - This invention provides a process for sequencing single-stranded DNA employing modified nucleotides. | 10-23-2014 |
20140314789 | CaMKII, IP3R, CALCINEURIN, P38 AND MK2/3 INHIBITORS TO TREAT METABOLIC DISTURBANCES OF OBESITY - The present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronary artery disease in a subject with a metabolic disorder, as well as methods of reducing hepatic glucose production in a subject. Such methods include, but are not limited to, the administration to the subject of inhibitors or activators of CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1, Dach2, or any combination thereof. The invention also provides methods of identifying a compound that inhibits the activity of CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1 or Dach2, or reduces the activity and/or activation of CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1 or Dach, or activates CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1 or Dach2. | 10-23-2014 |
20140306108 | METHOD OF COLLECTING AND PROCESSING ELECTRON DIFFRACTION DATA - A method of using electron diffraction to obtain PDFs from crystalline, nanocrystalline, and amorphous inorganic, organic, and organometallic compound. | 10-16-2014 |
20140303197 | METHODS OF TREATING AND PREVENTING LEUKEMIA AND OTHER CANCERS OF THE BLOOD AND BONE - The present invention relates to preventing and treating leukemia and other cancers of the blood and bone, as well as disorders of the blood, by inhibiting gut-derived serotonin. The inhibition of the gut-derived serotonin is accomplished by inhibiting Tph1, an enzyme responsible for the production of gut-derived serotonin. The present invention also relates to preventing and treating leukemia and other cancers of the blood and bone, as well as disorders of the blood, by increasing the number, growth and proliferation of osteoblasts. | 10-09-2014 |
20140302111 | COMPOSITIONS AND METHODS FOR DENTAL TISSUE REGENERATION - Provided is a method for regenerating dental tissue, which can include contacting a scaffold containing Wnt3a and BMP-7, and optionally VEGF, bFGF, or NGF, with a dental tissue so as to promote odontoblastic differentiation of a progenitor cell, promote progenitor cell migration into the dental tissue, or regenerate the dental tissue. Also provided is a composition for regeneration of dental tissue, which can include a scaffold and Wnt3a and BMP-7, and optionally VEGF, bFGF, or NGF. | 10-09-2014 |
20140299839 | ELECTRICAL DEVICES WITH GRAPHENE ON BORON NITRIDE - Methods of forming and resulting devices are described that include graphene devices on boron nitride. Selected methods of forming and resulting devices include graphene field effect transistors (GFETs) including boron nitride. | 10-09-2014 |
20140296878 | METHOD AND APPARATUS FOR CIRCULATORY VALVE REPAIR - An apparatus for the repair of a cardiovascular valve has leaflets comprising a grasper capable of grabbing and co-apting the leaflets of the valve. In a preferred embodiment, the grasper has jaws that grasp and immobilize the leaflets, and then a fastener is inserted to co-apt the leaflets. The apparatus is particularly useful for repairing mitral valves to cure mitral regurgitation. | 10-02-2014 |
20140296633 | REMOTE ENDOSCOPE HANDLE MANIPULATION - Systems and methods permit remote control of the operation of an endoscope. The system includes a control housing that removably attaches to an endoscope, with the housing including actuators and manipulators that engage with a control device of the endoscope in order to operate the control device. The system includes an axial roller that may be used to control the depth of the endoscope shaft within a patient's body. | 10-02-2014 |
20140296095 | Spatially Selective Release of Aptamer-Captured Cells by Temperature Mediation - Methods and systems are provided for capturing and releasing target cells. The system includes a microdevice having a microchamber including surface-patterned aptamers capable of binding with the target cells. A sample including target cells is introduced to the microchamber, where the target cells bind to the aptamers at locally regulated temperatures. The captured target cells can be selectively released when the temperature of a region is changed to a second temperature. | 10-02-2014 |
20140294798 | RbAp48 TRANSGENIC MICE FOR DRUG DISCOVERY IN AGE-RELATED MEMORY DECLINE - Described is a transgenic mouse with two transgenes, each of which transgene comprises a DNA sequence encoding a dominant negative form of RbAp48 protein, wherein the expression of the dominant negative form of RbAp48 is spatially restricted to the forebrain by a CaM Kinase IIa promoter and wherein the expression of the dominant negative form of RbAp48 is controlled by tetracycline-controlled transcriptional activation. Also provided are methods for evaluating in the transgenic mouse the potential therapeutic effect of an agent for slowing, inhibiting or preventing age-related memory decline in a mammalian subject. | 10-02-2014 |
20140288323 | CYCLOPROPENIMINE CATALYST COMPOSITIONS AND PROCESSES - The present invention provides, inter alia, a cyclopropenimine Brønsted base catalyst and a cyclopropenimine scaffold for use as a Brønsted base catalyst. This cyclopropenimine has the structure (100). Methods for making such a cyclopropenimine are also provided. Further provided are processes for carrying out an organic synthetic reaction and processes for catalyzing a proton transfer reaction enantioselectively using such a cyclopropenimine Brønsted base catalyst. | 09-25-2014 |
20140288119 | NOVEL MOLECULES THAT SELECTIVELY INHIBIT HISTONE DEACETYLASE 6 RELATIVE TO HISTONE DEACETYLASE 1 - This invention provides a compound having the structure: | 09-25-2014 |
20140287004 | Use of an Omega-3 Lipid-Based Emulsion Following Ischemic Injury to Provide Protection and Recovery in Human Organs - The present invention provides methods of limiting cell death or damage or reperfusion damage resulting from hypoxic-ischemia, comprising administering an omega-3 triglyceride emulsion after a hypoxic-ischemia insult. The omega-3 triglyceride emulsion preferably comprises from about 7% to 35% omega-3 oil by weight in grams per 100 ml of emulsion; the omega-3 oil comprises about 20% to 100% triglyceride by weight per total weight of the omega-3 oil and about 20% wt.-% to 100% of the acyl-groups of the omega-3 triglycerides consist of DHA; the omega-3 oil comprises less than 10% omega-6 fatty acids; and the mean diameter of lipid droplets in the emulsion is less than about 5 microns. | 09-25-2014 |
20140279778 | Systems and Methods for Time Encoding and Decoding Machines - Systems and methods for system identification, encoding and decoding signals in a non-linear system are disclosed. An exemplary method can include receiving the one or more input signals and performing dendritic processing on the input signals. The method can also encode the output of the dendritic processing of the input signals, at a neuron, to provide encoded signals. | 09-18-2014 |
20140275165 | COMPOUNDS THAT INHIBIT NFkB AND BACE1 ACTIVITY - The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds. | 09-18-2014 |
20140272974 | NOVEL RETROELEMENT FOUND IN MOLLUSKS - This invention relates to a novel retroelement, named “Steamer”, found in mollusks, more specifically | 09-18-2014 |
20140271643 | HUMAN NOTCH1 DECOYS - Provided herein are Notch1 fusion proteins. These fusion proteins comprise consecutive amino acids the sequence of which, commencing at the N-terminus of the fusion protein, is identical to the sequence of the amino acids in an extracellular domain of a human Notch1 receptor protein and an Fc portion of an antibody. The amino acid sequence of the extracellular domain (ECD) of the human Notch1 receptor protein commences with the amino acid present at the N-terminus of EGF-like repeat 10 and extends at least through the C-terminal amino acid of EGF-like repeat 23. The N-terminal portion of the ECD of the human Notch1 receptor protein may extend up to the C-terminal amino acid of EGF-like repeat 24 or may extend up to the C-terminal amino acid of EGF-like repeat 36. Compositions of these fusion proteins are also provided. Also provided are methods of treating age-related macular degeneration (AMD), diabetic retinopathy and cancer using the fusion proteins described herein. | 09-18-2014 |
20140268036 | METHODS FOR DIAGNOSING VITREO-RETINAL DISEASE - A quantitative method to analyze phase-resolved, raw backscatter echo data or the envelope of phase-resolved, raw backscatter echo data to characterize vitreous inhomogeneities as they relate to normal aging and vitreo-retinal disease. The technique can be applied to 2D or 3D data acquired from the vitreous. The approach provides an objective end value to characterize the vitreous and provide a tool for early diagnosis, monitoring and planning treatment of vitreo-retinal diseases. | 09-18-2014 |
20140267606 | Systems and Methods for Time Encoding and Decoding Machines - Systems and methods for system identification, encoding and decoding multi-component signals are disclosed. An exemplary method can include receiving the one or more multi-component signals and separating the multi-component signals into channels. The method can also filter each of the channels using receptive field components. The values for the receptive field components can be aggregated and provided to neurons for encoding. | 09-18-2014 |
20140258207 | Systems and Methods for Predicting Protein-Ligand Interactions - Systems and methods for predicting protein-ligand interactions are disclosed. An exemplary method can include identifying a set of structural neighbours of the query proteins, where each of contains ligands. The method can also determine a similarity score for each of the structural neighbours representing configuration similarity and interaction tendency between the structural neighbours and predict protein-ligand interactions of the one or more query proteins using the similarity scores. | 09-11-2014 |
20140254462 | METHODS, MEDIA, AND DEVICES FOR MOVING A CONNECTION FROM ONE POINT OF ACCESS TO ANOTHER POINT OF ACCESS - Systems, methods, media, and devices for providing cooperation among digital processing devices in wireless networks are provided. In some embodiments, methods for moving a connection from one point of access to another point of access are provided, sending a request for information from a first mobile node to at least one other node, wherein the request for information contains first information identifying at least one point of access; receiving a response containing second information identifying at least one point of access from the at least one other node; and establishing a connection between the first mobile node and a point of access identified in the second information. In some embodiments, devices that can move a connection from one point of access to another point of access are provided. | 09-11-2014 |
20140253199 | SYSTEMS, APPARATUS, AND METHODS FOR PROVIDING CONTINUOUS-TIME SIGNAL DIFFERENTIATION AND INTEGRATION - Systems and methods for providing an approximate differentiation and integration of an input continuous-time signal are provided. The disclosed systems include a continuous-time delay block configured to receive an input continuous-time signal and to delay the input continuous-time signal by a predetermined delay factor to generate a delayed input continuous-time signal, a processing block configured to determine a difference or a sum between two continuous-time signals, and a multiplication block configured to multiply an input continuous signal to provide a multiplied input continuous signal. | 09-11-2014 |
20140248709 | METHODS DEVICES AND SYSTEMS FOR OPTICAL PROBING OF MOLECULAR STRUCTURE AND INTERACTIONS - Non-linear spectroscopic devices, systems, and methods for probing molecules. A non-linear spectroscopic method for probing molecules can include providing a plurality of molecules in an aqueous solution, the providing being effective for permitting the molecules to be free in said aqueous solution and without the molecules being bound to another material such that second harmonic or sum frequency coherent light would result from the illumination of the molecules changes in their conformation. The method can also include probing the molecules by directing light at one or more selected frequencies to generate second harmonic or sum frequency incoherent light resulting from predefined interactions between the first and second molecules and capturing the incoherent light and detecting the same. | 09-04-2014 |
20140243404 | UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY - This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed. A representative halonium compound of the disclosure is: | 08-28-2014 |
20140242038 | METHOD FOR GENERATING BETA CELLS - The invention is directed to methods for generating pancreatic progenitor cells, insulin producing cells or endoderm cells using embryonic stem cells and induced pluripotent stem cells. The present invention also relates to an isolated population comprising pancreatic progenitor cells or a insulin-producing cells, compositions and their use in the treatment of diabetes | 08-28-2014 |
20140241554 | SYSTEMS, DEVICES, AND METHODS FOR CONTINUOUS-TIME DIGITAL SIGNAL PROCESSING AND SIGNAL REPRESENTATION - Systems, devices, and methods for continuous-time digital signal processing and signal representation are disclosed. This includes a continuous-time analog-to-digital converter that is configured to receive an analog signal and convert it to a continuous-time digital signal without using a clock or any type of sampling. This A/D conversion can include a per-level representation and a per-edge representation of the analog signal to produce a digital signal. The digital signal can then be processed in a continuous-time signal processor. The continuous time signal representation and processing can have benefits such a providing filters in high frequency applications where sampling is not practical. | 08-28-2014 |
20140239274 | OFET INCLUDING PVDF-TRFE-CFE DIELECTRIC - An organic electrical device can include a first dielectric substrate including a PVDF-TrFe-CFE terpolymer, a first semiconductor region coupled to a first surface of the first dielectric substrate, and a first gate region coupled to a second surface of the first dielectric substrate, the second surface opposite the first surface and opposite the first semiconductor region. The organic electrical device can include an organic field-effect transistor (OFET), comprising the first gate region, the first dielectric substrate, a first source region, and a first drain region respectively electrically coupled to the first semiconductor region. An electrostrictive actuator or mechanical sensor can be co-integrated on the first dielectric substrate, the actuator or sensor including first and second conductive regions located on opposite surfaces of the first dielectric substrate. The actuator or sensor can be electrically coupled to the OFET, and controlled at least in part by the OFET. | 08-28-2014 |
20140235973 | MEASUREMENT OF A FLUORESCENT ANALYTE USING TISSUE EXCITATION - An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided. | 08-21-2014 |
20140222783 | SYSTEMS AND METHODS FOR AUTOMATICALLY DETERMINING AN IMPROVED VIEW FOR A VISUAL QUERY IN A MOBILE SEARCH - Systems and methods for automatically determining an improved view for a visual query in a mobile location or object search are provided. In some embodiments, methods for automatically determining an improved view for a visual query in a mobile location or object search system include obtaining at least one data set based on a prior visual query, wherein the at least one data set includes at least a top location or object and one or more other locations or objects; retrieving at least one distinctiveness measurement for one or more locations or objects in the at least one data set; and determining the improved view based on the retrieved at least one distinctiveness measurement. | 08-07-2014 |
20140220687 | METHODS AND SYSTEMS FOR FORMING BIOCOMPATIBLE MATERIALS - Methods and systems forming biocompatible materials are disclosed herein. Forming a biocompatible material may include contacting a liquid, having a linking material, with an adjoining material having embedded therein a nucleating material that causes the linking material to nucleate and grow into the liquid. After a time sufficient to cause the linking material to grow substantially from the nucleating material into a space occupied by the liquid, the liquid may be solidified to form a solid such that the linking material secures the solid to the adjoining material. | 08-07-2014 |
20140220103 | HEMOSTATIC DRESSING FOR ARTERIAL BLEEDING - A wound treatment system having a formulation to retard bleeding. In particular, the wound treatment system includes medical device, e.g. bandage, which can be adapted for internal or external use. The wound treatment system includes a fabric substrate having a formulation, wherein the formulation includes chitosan, kaolin, fibrinogen, and thrombin. | 08-07-2014 |
20140218747 | CHIP-SCALE INTERFEROMETRY FOR HYPERENTANGLEMENT PROCESSING - An interferometer module for quantum processing is described including a substrate having two or more input ports and two or more output ports; multiple photonic pathways embedded in the substrate for conveying photons from the two or more input ports and the two or more output ports; and one or more partial beam splitters embedded in the substrate in a photonic pathway for generating spatial and polarization entanglement. | 08-07-2014 |
20140217264 | SYSTEMS AND METHODS FOR IMAGING USING SINGLE PHOTON AVALANCHE DIODES - Single-photon avalanche diode includes a central junction having a central p+ area and a deep-n well in contact with the central p+ area, a p-type guard ring disposed between the central junction and the deep-n well, and a shallow trench isolation separated from the central p+ area. Imaging apparatus includes a plurality of pixels, each pixel comprising a complementary metal-oxide-semiconductor-implemented single photon avalanche device and one or more signal converters electrically coupled thereto and configured to detect changes in output therefrom. | 08-07-2014 |
20140214095 | SYSTEMS AND DEVICES FOR THE REDUCTION AND ASSOCIATION OF BONES - In accordance with the disclosed subject matter, a medical device is provided which comprises a body having a first end and a second end, a first engaging member positioned adjacent the first end of the body and adapted to operatively engage a bone, and a second engaging member positioned adjacent the first end of the body and adapted to operatively engage the bone, wherein the position of at least one engaging member is adjustable with respect to the body. | 07-31-2014 |
20140212897 | METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY HCG ASSAY - The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample. | 07-31-2014 |
20140210138 | FORMING OR PATTERNING COMPOSITE MICROSTRUCTURES USING MICROFLUIDICS - Techniques comprising systems and methods for forming or pattering microstructures using microfluidics are described. A target structure can include a microchannel passage with a chamber into which a light hardenable material can be injected and selectively exposed to light to adhere to a desired location of a substrate. Unhardened material can be washed out of the chamber. One or more subsequent cycles can repeat the process using the same or a different material. A variety of composite microstructures can be created, including structures encapsulating viable living cells, such as for cell study or tissue engineering. | 07-31-2014 |
20140206553 | MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA - This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose. | 07-24-2014 |
20140202961 | System for Cleansing Organisms from Water - Techniques for depleting target organisms in water include a waterproof transducer configured for ensonifying a container of water with low intensity sound at one or more ultrasound frequencies for a duration sufficient to prevent maturation of at least 90% of the target organism. In some cases the target organism is mosquito larvae. For example, a portable system for depleting target organisms in water includes a control system and a plurality of waterproof transducers. The system is configured for ensonifying a surface layer of water in an acoustic frequency range from about 40 kilohertz to about 100 kilohertz and in a power concentration range from about 35 milliwatts per milliliter to 100 milliwatts per milliliter for a duration in a range from about 1 to about 100 seconds. | 07-24-2014 |
20140193935 | COLLECTIONS OF LATERALLY CRYSTALLIZED SEMICONDUCTOR ISLANDS FOR USE IN THIN FILM TRANSISTORS - Collections of laterally crystallized semiconductor islands for use in thin film transistors and systems and methods for making same are described. A display device includes a plurality of thin film transistors (TFTs) on a substrate, such that the TFTs are spaced apart from each other and each include a channel region that has a crystalline microstructure and a direction along which a channel current flows. The channel region of each of the TFTs contains a crystallographic grain that spans the length of that channel region along its channel direction. Each crystallographic grain in the channel region of each of the TFTs is physically disconnected from and crystallographically uncorrelated with each crystallographic grain in the channel region of each adjacent TFT. | 07-10-2014 |
20140192235 | SYSTEMS, METHODS, AND MEDIA FOR RECONSTRUCTING A SPACE-TIME VOLUME FROM A CODED IMAGE - Systems, methods, and media for reconstructing a space-time volume from a coded image are provided. In accordance with some embodiments, systems for reconstructing a space-time volume from a coded image are provided, the systems comprising: an image sensor that outputs image data; and at least one processor that: causes a projection of the space-time volume to be captured in a single image of the image data in accordance with a coded shutter function; receives the image data; and performs a reconstruction process on the image data to provide a space-time volume corresponding to the image data. | 07-10-2014 |
20140191139 | CONJUGATES OF NANO-DIAMOND AND MAGNETIC OR METALLIC PARTICLES - Techniques for imaging a characteristic of a sample with a plurality of conjugates of diamond-metallic nanoparticles having a nitrogen vacancy center. The plurality of conjugates can be exposed to a sample and the nitrogen vacancy centers can be optically pumped. One or more microwave pulses can be applied to the nitrogen vacancy center, and a fluorescent response can be detected. | 07-10-2014 |
20140187746 | PRECIPATABLE PEPTIDES - The invention is directed to a Ca2+ precipatable polypeptide tags and cassettes useful for purification of molecules from heterogeneous samples. The invention also relates to methods for bioseparation of molecules comprising Ca2+ precipatable tags and cassettes. | 07-03-2014 |
20140187536 | AGENTS FOR PREVENTING AND TREATING DISORDERS INVOLVING MODULATION OF THE RYANODINE RECEPTORS - Methods for reducing toxicity or side effects caused by administration of a rycal compound for repairing ryanodine receptor channel leaks when treating a disorder in a subject caused by such leaks. These methods are based upon the selection for administration of those rycal compounds having properties including an EC | 07-03-2014 |
20140187437 | Cross-Reactive Sensor Arrays And Methods of Use - Disclosed herein are methods and compositions directed to the construction of aptamer-based receptors and cross-reactive sensor arrays of such receptors and the use of the same in disease detection and management. | 07-03-2014 |
20140186747 | Composite Filaments having Thin Claddings, Arrays of Composite Filaments, Fabrication and Applications Thereof - A method of fabricating composite filaments is provided. An initial composite filament including a core and a cladding (such as a Pt-group metal) is cut into smaller pieces (or is first mechanically reduced and then cut into smaller pieces). The smaller pieces of the filaments are inserted into a metal matrix, and the entire structure is then further reduced mechanically in a series of reduction steps. The process can be repeated until the desired cross sectional dimension of the filaments is achieved. The matrix can then be chemically removed to isolate the final composite filaments with the cladding thickness down to the nanometer range. The process allows the organization and integration of filaments of different sizes, compositions, and functionalities into arrays suitable for various applications. Materials and components made from such composite filaments and arrays of composite filaments are also disclosed, | 07-03-2014 |
20140183736 | GRAPHENE ELECTRODES FOR ELECTRONIC DEVICES - A laminated graphene device is demonstrated as a cathode. In one example the devices include organic photovoltaic devices. The measured properties demonstrate work-function matching via contact doping. Devices and method shown also provide increased power conversion efficiency due to transparency. These findings indicate that flexible, light-weight all carbon devices, such as solar cells, can be constructed using graphene as the cathode material. | 07-03-2014 |
20140171484 | TISSUE-SPECIFIC MICRORNAS AND COMPOSITIONS AND USES THEREOF - The invention provides for isolated nucleic acid sequences of newly discovered micro RNAs that have been identified to exist in normal Human B cells and/or in tumor-related Human B cells, using an integrated bioinformatics method and pipeline described herein. | 06-19-2014 |
20140171380 | Screening Assays Using Stem Cells and Stem Cell-Derived Neurons from Mouse Models of Alzheimer's Disease - Successful CNS drug discovery requires a scalable, highly physiological neuronal model. Using directed differentiation of mouse embryonic stem (mES) cells, including mES cells isolated from a mouse model of Alzheimer's disease (AD), a highly homogeneous primary neuronal model amenable to phenotypic assays for production and synaptotoxicity of amyloid β-peptide was developed. This model furnishes a highly physiological and AD-relevant platform suitable for high throughput small molecule and functional genetic screens, providing specific small molecule compounds identified by such screens. | 06-19-2014 |
20140171365 | PEGYLATED HUMAN HDL PARTICLE AND PROCESS FOR PRODUCTION THEREOF - Compositions comprising pegylated high density lipoprotein (HDL) particles, methods for producing compositions comprising pegylated HDL particles, and methods of treating various diseases and conditions using pegylated HDL particles are provided. | 06-19-2014 |
20140168422 | DISPLACEMENT MONITORING SYSTEM HAVING VIBRATION CANCELLATION CAPABILITIES - Techniques for vision-based sensing of structural displacement of an object, are disclosed. An example system includes digital video cameras adapted to generate digital image information corresponding to features of the object, an input to receive the digital image information corresponding to the one or more features, a converter configured to convert the digital image information into templates, and a comparator to compare the templates in sequence and to subtract displacement of stationary reference features. | 06-19-2014 |
20140167898 | SYSTEMS AND METHODS FOR COUPLED POWER INDUCTORS - Power inductor has a magnetically isotropic core including two or more laminations. At least a first lamination can include anisotropic magnetic material having a first orientation of magnetic anisotropy. At least a second lamination can include anisotropic magnetic material having a second orientation of magnetic anisotropy, the second orientation being different than the first orientation. | 06-19-2014 |
20140163759 | DIGITAL BUILDING OPERATING SYSTEM WITH AUTOMATED BUILDING AND ELECTRIC GRID MONITORING, FORECASTING, AND ALARM SYSTEMS - A system and method for monitoring status of an electrical grid and one or more building subsystems. The system includes sensors in communication with an electrical grid, buildings that provide data related to the building subsystems, and a digital building operating system that includes a processor that performs instructions to process the data, identify the status of the electrical grid and the building subsystem, predict one or more events based on the data, and provide recommendations to the buildings such as how to prevent the bad event. | 06-12-2014 |
20140161206 | METHODS, SYSTEMS, AND MEDIA FOR FORMING LINEAR COMBINATIONS OF DATA - Methods, systems, and media for forming linear combinations of data are provided. In some embodiments, methods for forming a linear combination of data include: receiving at a device a first codeword, wherein the first codeword comprises a linear combination of at least a first data unit including data, and a second data unit including data; encoding at the device the first codeword and a third data unit including data to form a second codeword, wherein the second codeword includes a linear combination of at least the first data unit, the second data unit, and the third data unit; and transmitting from the device the second codeword. | 06-12-2014 |
20140160336 | LENS-FREE PLANAR IMAGER AND WIRELESS TRANSMITTER - Techniques for lens-free imaging using optical resonance, including providing a series of standing waves indexed by a wave vector to an optical resonator having a predetermined dispersion relation. The intensity of the wavelengths corresponding to the standing waves can be measured with a photodetector. A magnitude and shift of the wave vector corresponding to each of the standing waves can be determined, and spatial information in k-space can be determined from the magnitude and shift of the wave vector corresponding to each of the standing waves using an inversion relationship. A transform can be applied to the spatial information to generate an image. | 06-12-2014 |
20140158871 | SYSTEMS AND METHODS FOR SENSING PROPERTIES OF A WORKPIECE AND EMBEDDING A PHOTONIC SENSOR IN METAL - Systems and methods for sensing properties of a workpiece and embedding a photonic sensor in metal are disclosed herein. In some embodiments, systems for sensing properties of a workpiece include an optical input, a photonic device, an optical detector, and a digital processing device. The optical input provides an optical signal at an output of the optical input. The photonic device is coupled to the workpiece and to the output of the optical input. The photonic device generates an output signal in response to the optical signal, wherein at least one of an intensity of the output signal and a wavelength of the output signal depends on at least one of thermal characteristics and mechanical characteristics of the workpiece. The optical detector receives the output signal from the photonic device and is configured to generate a corresponding electronic signal. The digital processing device is coupled to the optical detector and determines at least one of the thermal characteristics and mechanical the characteristics of the workpiece based on the electronic signal. | 06-12-2014 |
20140156031 | Adaptive Stochastic Controller for Dynamic Treatment of Cyber-Physical Systems - Techniques for generating a dynamic treatment control policy for a cyber-physical system having one or more components, including a data collector for collecting data representative of the cyber-physical system, and adaptive stochastic controller including one or more models for generating a predicted value corresponding to available actions based on an objective function, and an approximate dynamic programming element configured to receive actual operation metrics corresponding to the available actions. The approximate dynamic programming element can learn a state-action map and generate a dynamic treatment control policy using the one or more models. | 06-05-2014 |
20140155730 | APPARATUS, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR DIAGNOSING AND SUBTYPING PSYCHIATRIC DISEASES - Exemplary method, system and computer-accessible medium can be provided for diagnosing at least one disease and/or a subtype within a disease. For example, it is possible to determine at least one region of interest, and obtain a plurality of data points associated with each of such region(s) of interest. It is also possible to identify a particular pattern of the data points across each of such region(s) of interest. Further, it is possible, e.g., using a computer arrangement, to determine a likelihood of the disease(s) and/or the subtype by comparing the particular pattern to at least one known pattern. | 06-05-2014 |
20140154340 | METHODS TO TREAT CANCER USING CYCLOSPORINE AND CYCLOSPORINE DERIVATIVES - Methods to treat certain types of cancer with cyclophilin inhibitors. | 06-05-2014 |
20140153926 | CHIP INTEGRATED SINGLE PHOTON GENERATION BY ACTIVE TIME MULTIPLEXING - Techniques for converting signal and idler photons generated by a nonlinear optical system into a deterministic stream of single photons including receiving a heralded, nondeterministic source of signal and idler photons from the nonlinear optical process, separating one or more received signal photons from one or more received temporally corresponding idler photons, determining whether at least one of the one or more signal photons should be variably delayed, and if so, determining a delay length, and variably delaying the emission of one of the one or more signal photons, if any, by the determined delay length. | 06-05-2014 |
20140152278 | SYSTEMS AND METHODS FOR SWITCHED-INDUCTOR INTEGRATED VOLTAGE REGULATORS - Power controller includes an output terminal having an output voltage, at least one clock generator to generate a plurality of clock signals and a plurality of hardware phases. Each hardware phase is coupled to the at least one clock generator and the output terminal and includes a comparator. Each hardware phase is configured to receive a corresponding one of the plurality of clock signals and a reference voltage, combine the corresponding clock signal and the reference voltage to produce a reference input, generate a feedback voltage based on the output voltage, compare the reference input and the feedback voltage using the comparator and provide a comparator output to the output terminal, whereby the comparator output determines a duty cycle of the power controller. An integrated circuit including the power controller is also provided. | 06-05-2014 |