| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK Patent applications |
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| 20120135539 | Split DNA Enzyme for Visual Single Nucleotide Polymorphism Typing - A probe that changes solution color in the presence of only one of the two DNA sequences, which differ by a single nucleotide, is reported. The probe consists of two oligodeoxyribonucleotides, which form a hydrogen peroxidase-like DNA enzyme when hybridized to the abutting fragments of the complementary analyte. The active peroxidase catalyses oxidation of colorless substrates to the colored products. The probe allows visual detection of a mutation in Alzheimer's disease-related DNA. | 05-31-2012 |
| 20120126199 | PREPARING NANOPARTICLES AND CARBON NANOTUBES - Apparatus and methods for forming the apparatus include nanoparticles, catalyst nanoparticles, carbon nanotubes generated from catalyst nanoparticles, and methods of fabrication of such nanoparticles and carbon nanotubes. | 05-24-2012 |
| 20120124393 | System and Methods for Silencing Hardware Backdoors - Methods for preventing activation of hardware backdoors installed in a digital circuit, the digital circuit comprising one or more hardware units to be protected. A timer is repeatedly initiated for a period less than a validation epoch, and the hardware units are reset upon expiration of the timer to prevent activation of a time-based backdoor. Data being sent to the hardware unit is encrypted in an encryption element to render it unrecognizable to a single-shot cheat code hardware backdoor present in the hardware unit. The instructions being sent to the hardware unit are reordered randomly or pseudo-randomly, with determined sequential restraints, using an reordering element, to render an activation instruction sequence embedded in the instructions unrecognizable to a sequence cheat code hardware backdoor present in the hardware unit. | 05-17-2012 |
| 20120123739 | System and Methods for Precise Microprocessor Event Counting - Method for providing precise microprocessor performance counter readings including detecting a swap back to a monitored process executing in a microprocessor. In response to the detected swap back to the monitored process, if the value read from the performance counter does not exceed the defined overflow threshold, the value of the performance counter stored in the first memory location is restored to the performance counter. If the value read from the performance counter exceeds the defined overflow threshold, the performance counter is set to zero and the value of the performance counter stored in the first memory location is used to increment an overflow memory location. If the value read from the performance counter exceeds the defined overflow threshold, at least one performance counter reading instruction is detected and in response to the detected at least one performance counter reading instruction, setting the counter output register to zero. | 05-17-2012 |
| 20120116287 | PHOTOLABILE COMPOUNDS - The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect. | 05-10-2012 |
| 20120115778 | Methods of Suppressing Appetite by the Administration of Antagonists of the Serotonin HTR1a or HTR2b Receptors or Inhibitors of TPH2 - Methods for treating eating disorders associated with excessive weight gain, suppressing appetite, reducing body weight, or treating obesity in an animal by administering one or more antagonists of the serotonin Htr1a or Htr2b receptor, or a Tph2 inhibitor are provided, or combinations thereof. | 05-10-2012 |
| 20120114558 | APTAMER-MEDIATED DRUG RELEASE - The present invention relates to aptamer/drug conjugate complexes and the use of such complexes, together with a trigger compound, to inducibly release a drug. Through these complexes, the present invention provides a means for establishing a drug reservoir in a subject, whereby drug may be released as needed. One specific embodiment of the invention provides an aptamer/insulin conjugate complex from which insulin may be released by an innocuous, orally administrable trigger, such as quinine. | 05-10-2012 |
| 20120109274 | ELECTRODE ARRAYS AND SYSTEMS FOR INSERTING SAME - Electrode arrays and systems for inserting same are disclosed. In some embodiments, electrode arrays are provided, the electrode arrays comprising: a passive-bending portion; an active-bending portion coupled to the passive bending portion; a plurality of electrodes located in at least one of the passive-bending portion and the active bending portion; and an actuator that causes the active-bending portion to deflect from the passive-bending portion. In some embodiments, systems for inserting an electrode array in the body are provided, the systems comprising: an insertion module for controllably inserting the electrode array in the body and sensing forces applied to the electrode array; a monitor for providing information to a user; and a controller coupled to the insertion module and the monitor, wherein the controller causes the insertion module to control an amount of force that is applied to the electrode array. | 05-03-2012 |
| 20120108883 | SYSTEMS AND METHODS FOR INDUCING ELECTRIC FIELD PULSES IN A BODY ORGAN - Systems and methods for providing controllable pulse parameter magnetic stimulation are described. One aspect is directed to a magnetic stimulation system for inducing approximately rectangular electric field pulses in a body organ, comprising an electrical energy storage device, a stimulating coil, and a switching means for electrically coupling said electrical energy storage device to said stimulating coil to produce current pulses in said stimulating coil which generates, in response to the current pulses, magnetic field pulses that can induce approximately rectangular electric field pulses in the body organ. | 05-03-2012 |
| 20120103903 | METHODS, APPARATUS, AND SYSTEMS FOR SEPARATING FLUIDS - A device for separating fluids includes a microfluidic channel with one or more wall filters or membranes through which portions of the flow in the microfluidic channel can be removed. The wall filters can have precisely defined pores therein which restrict the removal of certain particles while allowing other particles and/or fluids to freely flow therethrough. Because of the high and uniform pore density and low flow resistance of these filters, the pressure drop along the microfluidic channel may result in a negative trans-filter pressure, thereby causing reverse flow of extracted fluid back through the filter and into the microfluidic channel. Precise design of the microfluidic channel and control of flow characteristics can minimize and/or eliminate this reverse flow while allowing for sufficient sweeping of the filter surface to inhibit clogging with particles. | 05-03-2012 |
| 20120103901 | SYSTEMS AND METHODS OF MICROFLUIDIC MEMBRANELESS EXCHANGE USING FILTRATION OF EXTRACTION OUTLET STREAMS - A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration. | 05-03-2012 |
| 20120095490 | ENDOVASCULAR FLEXIBLE STAPLING DEVICE - The present invention concerns a flexible stapling device ( | 04-19-2012 |
| 20120095095 | USE OF AN OMEGA-3 LIPID-BASED EMULSION FOLLOWING ISCHEMIC INJURY TO PROVIDE PROTECTION AND RECOVERY IN HUMAN ORGANS - The present invention provides methods of limiting cell death resulting from hypoxic-ischemia comprising, administering an omega-3 lipid-based emulsion after a hypoxic-ischemia insult. The omega-3 lipid-based emulsion preferably comprises at least 20% omega-3 oil, by weight, and wherein the omega-3 oil comprises at least 20% omega-3 triglycerides and/or diglycerides, and wherein fatty acids of the omega-3 trigylceride and/or diglycerides comprise at least 40% EPA and/or DHA. The present invention also provides novel fish-oil compositions for administration after an ischemic insult to limit cell death in the organ that underwent an ischemic event. | 04-19-2012 |
| 20120084040 | Systems And Methods Of Channel Identification Machines For Channels With Asynchronous Sampling - Method for identification of at least one parameter of a sampling system includes transmitting at least one input signal to at least one channel of the sampling system; measuring at least one output signal of the sampling system in response to sampling of the at least one input signal by the receiver; and determining, using a processor, the at least one parameter of the sampling system using the at least one input signal and the at least one output signal of the sampling system. A system for identification of at least one parameter relating to a sampling system in response to at least one input signal is also provided. | 04-05-2012 |
| 20120083421 | USE OF URINARY NGAL TO DIAGNOSE AND MONITOR HIV-ASSOCIATED NEPHROPATHY (HIVAN) - The present invention is directed to methods for diagnosis of HIVAN, and to methods for distinguishing between HIVAN and other kidney diseases, based on the presence in a bodily fluid, such as urine, of a level of NGAL protein that exceeds a threshold level. The present invention is also directed to methods for diagnosis of HIVAN based on the differential expression of NGAL and one or more other markers, such as uL-FABP or KIM-1, and to methods of diagnosis based on a specific localization of NGAL in microcysts or microcystic tubules of the kidney. | 04-05-2012 |
| 20120071356 | Variants in Complement Regulatory Genes Predict Age-Related Macular Degeneration - Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and kits for use in these methods are also provided. | 03-22-2012 |
| 20120064246 | GROWTH AND APPLICATIONS OF ULTRALONG CARBON NANOTUBES - Ultralong carbon nanotubes can be formed by placing a secondary chamber within a reactor chamber to restrict a flow to provide a laminar flow. Inner shells can be successively extracted from multi-walled carbon nanotubes (MWNTs) such as by applying a lateral force to an elongated tubular sidewall at a location between its two ends. The extracted shells can have varying electrical and mechanical properties that can be used to create useful materials, electrical devices, and mechanical devices. | 03-15-2012 |
| 20120064099 | COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY - The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds. | 03-15-2012 |
| 20120061304 | SYSTEMS AND METHODS FOR MEMBRANELESS DIALYSIS - Devices, systems and methods are disclosed for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The embodiments may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of small molecules, middle molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid. | 03-15-2012 |
| 20120043203 | SENSORS FOR LONG-TERM AND CONTINUOUS MONITORING OF BIOCHEMICALS - The disclosed subject matter relates to a sensor or system for monitoring a target analyte by using a polymer solution that is capable of binding to the analyte. The sensor of the disclosed subject matter includes a viscosity-based sensor or a permittivity-based sensor. The viscosity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber including a vibrational element. The permittivity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber. The sensor discussed herein provides excellent reversibility and stability as highly desired for long-term analyte monitoring. | 02-23-2012 |
| 20120040867 | Microarrays of Binary Nucleic Acid Probes for Detecting Nucleic Acid Analytes - Some embodiments of the invention are directed to a microarray of binary nucleic acid probes for the detection of one or a plurality of nucleic acid analytes in a complex sample in a single high throughput assay with extraordinary specificity under physiologic conditions. Any binary nucleic acid probes that generate a detectable signal when bound to analyte are suitable for use in the microarrays, including binary deoxyribozyme or ribozyme probes; nonenzymatic binary probes for fluorescent detection, nonenzymatic binary dye-binding probes, and binary split enzyme peroxidase probes for visual detection of nucleic acids. The invention is also directed to new non nonenzymatic binary probes that bind to reporter oligonucleotides. | 02-16-2012 |
| 20120037818 | SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIA FOR OBTAINING THREE-DIMENSIONAL INFORMATION FROM TWO-DIMENSIONAL FLUORESCENCE EMISSION DATA - Exemplary embodiments of a computer-accessible medium, method and system for providing information are provided. A first detection arrangement can be provided which can be configured to detect electro-magnetic radiations from a fluorescent particle(s) in a portion of a structure, and generate information associated with the portion of the structure. A second arrangement can be configured to generate a two-dimensional image and/or a three-dimensional image of the at least one portion of the structure as a function of the information. The electro-magnetic radiations can have different wavelengths. | 02-16-2012 |
| 20120028241 | Assay System for Monitoring the Effects of Genetically Engineered Cells to Alter Function of a Synctium - This invention provides methods for determining the ability of a gene construct to alter the rhythm and contractility of a syncytial cell. Furthermore, this invention provides methods for constructing a gene construct capable of altering the rhythm or contractility of a syncytial cell. Finally, this invention provides a method for constructing a gene construct capable of coupling to a syncytial cell. | 02-02-2012 |
| 20120008495 | Methods And Systems For Controlling SIP Overload - Techniques for controlling Session Initiation Protocol (SIP) overload between a sending entity and a receiving entity includes receiving a message at a send buffer at the sending entity and forwarding the message to a receive buffer at the receiving entity if the send buffer is empty of other messages or rejecting the message if the send buffer is not empty of other messages. | 01-12-2012 |
| 20110314367 | System And Method For Annotating And Searching Media - A system and method for labeling and classifying multimedia data is provided that includes novel label propagation techniques and classification function characteristics. The system and method corrects and propagates a small number of potentially erroneous labels to a large amount of multimedia data and generate optimal ways of ranking, classification, and presentation of the data sets. The disclosed systems and methods improve upon prior systems and methods and provide an improved approach to the problems of imbalanced data sets and incorrect label data. | 12-22-2011 |
| 20110309370 | SYSTEMS AND METHODS FOR THE CRYSTALLIZATION OF THIN FILMS - Crystallization of thin films using pulsed irradiation The method includes continuously irradiating a film having an x-axis and a y-axis, in a first scan in the x-direction of the film with a plurality of line beam laser pulses to form a first set of irradiated regions, translating the film a distance in the y-direction of the film, wherein the distance is less than the length of the line beam, and continuously irradiating the film in a second scan in the negative x-direction of the film with a sequence of line beam laser pulses to form a second set of irradiated regions, wherein each of the second set of irradiated regions overlaps with a portion of the first set of irradiated regions, and wherein each of the first and the second set of irradiated regions upon cooling forms one or more crystallized regions. | 12-22-2011 |
| 20110306840 | CONTROLLABLE MAGNETIC SOURCE TO FIXTURE INTRACORPOREAL APPARATUS. - A first magnetic field can be produced across a tissue region using a first magnetic field source, providing a magnetic coupling force between the first magnetic field source and a first object, wherein the first object provides a magnetic field or a magnetic susceptibility to obtain the magnetic coupling force. The magnetic coupling force can be sensed using a force sensor and a resulting sensed force signal can be provided to a controller. The controller can provide an output signal to control the magnetic coupling force using the sensed forced signal to obtain a constant or desired magnetic coupling force. | 12-15-2011 |
| 20110306045 | Method for Confirming a Diagnosis of Rolandic Epilepsy - A strong association between variants in Elongator Protein Complex 4, (ELP4) (specifically single nucleotide polymorphisms, SNPs) at the 11p13 locus on chromosome 11 and the centrotemporal sharp wave trait (CTS) has been discovered, which association has diagnostic significance for rolandic epilepsy. It has further been discovered that the 11p13 locus has a pleiotropic role in the development of speech motor praxis and CTS, which supports a neurodevelopmental origin for classic rolandic epilepsy (RE). | 12-15-2011 |
| 20110301495 | IMAGES OF LANGUAGE-SENSITIVE NEUROCIRCUITRY AS A DIAGNOSTIC FOR AUTISM - The disclosed subject matter provides on ore more imaging techniques during passive auditory stimulation to objectively provide a diagnostic indicator of ASD. These techniques include functional MRI (fMRI), diffusion tensor imaging (DTI) and tractography, and combinations thereof. In one embodiment, a method is disclosed that uniquely provides an objective (imaging) physiological technique to diagnose early autism and to monitor progress following therapeutic intervention. | 12-08-2011 |
| 20110300543 | METHODS FOR MAKING INDUCED PLURIPOTENT STEM CELLS FROM MESENCHYMAL STEM CELLS - The invention is directed to methods for making iPS cells from Mesenchymal Stem Cells (MSCs). In certain aspects the methods comprise expression of Oct4 in MSCs, thereby converting the MSCs to iPS cells. | 12-08-2011 |
| 20110295105 | SYSTEMS AND METHODS FOR OPENING A TISSUE - Systems and methods for opening a tissue to a target value are disclosed herein. In an exemplary method, a region of the tissue is targeted for opening, a size range of microbubbles corresponding to the target value is determined, microbubbles of the size range are positioned in proximity to the targeted region, and an ultrasound beam is applied to the targeted region such that the tissue is opened with the assistance of the microbubbles to the target value. | 12-01-2011 |
| 20110294874 | DIAGNOSIS AND THERAPY OF ORGAN DYSFUNCTION USING SPHINGANINE-1-PHOSPHATE - The invention relates to the treatment and diagnosis of organ dysfunction caused by ischemia reperfusion injury. In particular, the invention relates to sphinganine-1-phosphate, a sphingolipid metabolite, and its use in the diagnosing, preventing, and/or treating ischemia reperfusion-associated disorders, including, without limitation, disorders of the kidney, liver, lung, brain, and heart. | 12-01-2011 |
| 20110294800 | HYPOGLYCEMIC DIHYDROPYRIDONES - The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods of treatment or prevention of diabetes or hyperglycemia in a patient, and of normalizing blood glucose levels in a subject, by administering an effective amount of a compound of formula I. | 12-01-2011 |
| 20110287056 | AGENTS AND METHODS TO ELICIT ANTI-TUMOR IMMUNE RESPONSE - The invention provides an isolated, purified population of human cells comprising CD8+ T cells with reduced Cbl-b activity. The invention provides uses of such cells in methods for inducing or enhancing an anti-tumor immune response in a subject. These methods comprise: (a) providing a cell population, from a subject or from another source, which comprises CD8+ T cells, (b) reducing Cbl-b activity in the CD8+ T-cells, (c) administering the cells of step (b) to the subject. The invention provides methods for making CD8+ T cells that do not require stimulation through a co-receptor in order for the cell to become activated or proliferated in response to contact via its T cell receptor. Such methods are based upon reducing function of Cbl-b. The invention also provides methods for identifying agents which affect Cbl-b expression or activity. | 11-24-2011 |
| 20110286489 | ALL-SILICON RAMAN AMPLIFIERS AND LASER BASED ON MICRO RING RESONATORS - Devices for generating a laser beam are disclosed. The devices include a silicon micro ring having at least one silicon optical waveguide disposed at a distance from the micro ring. The radius and the cross-sectional dimension of the micro ring, the cross-sectional dimension of the waveguide, and the distance between the micro ring and the waveguide are determined such that one or more pairs of whispering gallery mode resonant frequencies of the micro ring are separated by an optical phonon frequency of silicon. Methods of manufacturing a lasing device including a silicon micro ring coupled with a silicon waveguide are also disclosed. | 11-24-2011 |
| 20110281899 | METHODS OF PREVENTING AND TREATING LOW BONE MASS DISEASES - The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis and the agents are TPH1 inhibitors or serotonin receptor antagonists. | 11-17-2011 |
| 20110275156 | Delivery of DNA or RNA Via Gap Junctions from Host Cells to Target Cells and a Cell-Based Delivery System for Antisense or siRNA - A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell. | 11-10-2011 |
| 20110275062 | Systems And Methods For Integrating A Single DNA Molecule Into A Molecular Electronic Device - The disclosed subject matter provides a techniques for precisely and/or functionally cutting carbon nanotubes, e.g., single walled carbon nanotubes (“SWNTs”) and integrating a single nucleic acid molecule (e.g., a DNA molecule) into a gap formed into the carbon nanotubes. In one aspect, a method of fabricating a molecular electronic device includes disposing a SWNT on a base layer, forming a gap in the SWNT using a lithographic process, and disposing a single DNA strand across the gap so that each end of the nucleic acid contacts a gap termini. The disclosed subject matter also provides techniques for measuring the electrical properties (charge transport) of a DNA molecule which is integrated into an SWNT. Furthermore, a molecular electronic device including an SWNT with an integrated nucleic acid molecule is disclosed. | 11-10-2011 |
| 20110268884 | FORMATION OF NANOSCALE CARBON NANOTUBE ELECTRODES USING A SELF-ALIGNED NANOGAP MASK - A first single-wall carbon nanotube can be electrically coupled to a first electrode, and a second single-wall carbon nanotube electrically coupled to a second electrode. In an example, the first and second single-wall carbon nanotubes are laterally separated by a nanoscale gap, such as sized and shaped for insertion of a single molecule. | 11-03-2011 |
| 20110259361 | DETERGENT COMPOSITIONS UTILIZING HYDROPHOBICALLY MODIFIED POLYMER - Embodiments of the invention relate to a detergent composition including a poly(maleic acid/vinyl octyl ether) (PMAOVE) hydrophobically modified polymer; and a heavy duty liquid detergent. In addition, embodiments relate to a method of cleaning a substrate, including contacting a substrate with a poly(maleic acid/vinyl octyl ether) (PMAOVE) hydrophobically modified polymer solution. | 10-27-2011 |
| 20110258939 | METHODS FOR PRODUCING NANOPARTICLES HAVING HIGH DEFECT DENSITY AND USES THEREOF - The disclosed subject matter is directed to a method for producing nanoparticles, as well as the nanoparticles produced by this method. In one embodiment, the nanoparticles produced by the disclosed method have a high defect density. A solution including cerium nitrate hexahydrate is combined with a solution including hexamethylenetetramine to form a combined aqueous solution. After a period of time, the combined aqueous solution is combined with a solution including copper nitrate trihydrate to form a further aqueous solution. The further aqueous solution is then mixed to produce nanoparticles. | 10-27-2011 |
| 20110256112 | Compensating for Atrioventricular Block Using a Nucleic Acid Encoding a Sodium Channel or Gap Junction Protein - A method of increasing the velocity of AV conduction in a mammal that may be in heart block or at risk of heart block by causing, in an AV node and/or His bundle having less than normal conduction speed, the expression of a sodium channel or gap junction protein, such as the SkM-1 channel, Cx43 or Cx32, so as to increase the velocity of conduction by the AV node. | 10-20-2011 |
| 20110249689 | DEVICES, SYSTEMS, AND METHODS PROVIDING MICRO-RING AND/OR MICRO-RACETRACK RESONATOR - Provided herein are certain embodiments of systems, methods and devices for Raman lasers based on micro-ring and mircro-racetrack resonators, and the manufacturing thereof. For example, a device can be provided which is structured to receive an electro-magnetic radiation including a resonator arrangement which has a distance from one edge thereof to another edge thereof of at most approximately a wavelength of the electro-magnetic radiation that impacts the resonator arrangement. According to some embodiments, the resonator arrangement can be configured to generate a Raman radiation when impacted by a further electro-magnetic radiation. In some embodiments, the resonator arrangement can solely generate the Raman radiation which is lasing, which Raman radiation can be generated by the resonator arrangement in a continuous mode and/or a pulsed lasing mode. The resonator arrangement can generate the Raman radiation which is lasing without a use of an external electrical driver. | 10-13-2011 |
| 20110244006 | MICROSPHERE SKIN TREATMENT - This application provides a microsphere suitable for tissue engineering that comprises connective tissue growth factor (CTGF). Also provided is a matrix, material or scaffold suitable for tissue engineering that comprises connective tissue growth factor (CTGF) and basic fibroblast growth factor (bFGF). Additionally, methods of treating skin of a human are provided. The methods comprise administering to the skin microspheres comprising a growth factor that increases fibroblast proliferation or collagen, elastin, or glycosaminoglycan synthesis. Further provided are the use of the above microspheres for the treatment of the skin of a human. Additionally, this application proves the use of the above microsphere for the manufacture of a medicament for the treatment of the skin of a human. | 10-06-2011 |
| 20110236977 | DENTAL STEM CELL DIFFERENTIATION - Provided is a method of preparing an embryonic stem cell-like cell, a method of preparing an insulin-secreting cell or pancreatic beta-like cell, a method of preparing a chondrocyte-like cell, a method of preparing a myocyte-like cell, and a method of preparing a hair follicle-like cell. A composition comprising a dental stem cell and an insulin-secreting cell or a pancreatic beta-like cell is also provided. Further, a composition comprising (a) a dental stem cell and (b) a chondrocyte-like cell, a myocyte-like cell, or a hair follicle-like cell is provided. Additionally provided is an insulin-secreting cell or a pancreatic beta-like cell differentiated from a dental stem cell. Further provided is a chondrocyte-like cell, a myocyte-like cell, or a hair follicle-like cell, derived from a dental stem cell. | 09-29-2011 |
| 20110233046 | DEVICES, APPARATUS AND METHOD FOR PROVIDING PHOTOSTIMULATION AND IMAGING OF STRUCTURES - According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain slices in any arbitrary spatio-temporal pattern, using two-photon uncaging of photo-sensitive compounds such as MNI-glutamate and/or RuBi-Glutamate with beam multiplexing. Such exemplary method and device can have single-cell and three-dimensional precision. For example, by sequentially stimulating up to a thousand potential presynaptic neurons, it is possible to generate detailed functional maps of inputs to a cell. In addition, it is possible to combine this exemplary approach with two-photon calcium imaging in an all-optical method to image and manipulate circuit activity. Further exemplary embodiments of the present disclosure can include a light-weight, compact portable device providing for uses in a wide variety of applications. | 09-29-2011 |
| 20110231213 | METHODS AND SYSTEMS OF DETERMINING THE EFFECTIVENESS OF CAPITAL IMPROVEMENT PROJECTS - The present application provides methods and systems for quantitatively predicting an effectiveness of a proposed capital improvement project based on one or more previous capital improvement projects representative of one or more physical assets and including one or more attributes that includes defining a first sample pool from the previous capital improvement project data in which said previous capital improvement project has been performed, defining a second sample in which the previous capital improvement project has not been performed, the second sample pool including one or more attribute values that are the same as, or similar to, the attribute values for the first sample pool, generating a performance metric for each of the first and second sample pools, comparing the performance metric from the first sample pool with the performance metric from the second sample pool to determine a net performance metric, and, generating a prediction of effectiveness of the proposed capital improvement project concerning based on said net performance metric. | 09-22-2011 |
| 20110230894 | SYSTEMS, DEVICES, AND METHODS FOR PROVIDING INSERTABLE ROBOTIC SENSORY AND MANIPULATION PLATFORMS FOR SINGLE PORT SURGERY - The present disclosure relates to systems, devices, and methods for providing foldable, insertable robotic sensory and manipulation platforms for single port surgery. The device is referred to herein as an Insertable Robotic Effector Platform (IREP). The IREP provides a self-deployable insertable device that provides stereo visual feedback upon insertion, implements a backbone structure having a primary backbone and four secondary backbones for each of the robotic arms, and implements a radial expansion mechanism that can separate the robotic arms. All of these elements together provide an anthropomorphic endoscopic device. | 09-22-2011 |
| 20110224536 | SYSTEMS AND METHODS FOR DETERMINING A TEMPERATURE DIFFERENTIAL USING TEMPERATURE SENSITIVE MAGNETIC RESONANCE IMAGING - A method and apparatus for determining a temperature differential at a portion of a patient's body utilizing temperature sensitive MRI measurements. A diagnostic fluid bolus is administered into a blood vessel of the patient, wherein the diagnostic fluid bolus has a diagnostic fluid bolus temperature waveform. MRI measurements are used to determine the thermodiluted temperature waveform of the diagnostic fluid bolus at a target site in the body spaced away from the administration site. The temperature differential may be used to determine a cardiovascular parameter. | 09-15-2011 |
| 20110223144 | Creation of a Biological Atrioventricular Bypass to Compensate for Atrioventricular Block - A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle. | 09-15-2011 |
| 20110214161 | METHODS, MEDIA, AND SYSTEMS FOR SECURING COMMUNICATIONS BETWEEN A FIRST NODE AND A SECOND NODE - Methods, media, and systems for securing communications between a first node and a second node are provided. In some embodiments, methods for securing communication between a first node and a second node are provided. The methods comprising: receiving at least one model of behavior of the second node at the first node; and authorizing the first node to receive traffic from the second node based on the difference between the at least one model of behavior of the second node and at least one model of behavior of the first node. | 09-01-2011 |
| 20110208038 | Systems And Methods For Matching And Imaging Tissue Characteristics - Systems and methods for matching a characteristic of multiple sectors of a moving tissue to verify an overlap thereof are disclosed herein. In an exemplary method, tissue data for at least a first sector and a second sector of a moving tissue is acquired. A characteristic of at least a portion of the first and second sectors is estimated from the acquired tissue data, and the estimated characteristics are matched to verify whether a portion of the first sector overlaps with a portion of the second sector. Estimating can include estimating a displacement such as an axial displacement and/or lateral displacements. Estimating can further include estimating a strain, a velocity, a strain rate and/or a stiffness or equivalent. | 08-25-2011 |
| 20110202142 | BIOLOGICALLY DERIVED COMPOSITE TISSUE ENGINEERING - The present application is directed to engineering of tissues, especially composite tissues such as a joint. Various aspects of the application provide tissue modules and methods of fabrication and use thereof. Some embodiments provide a tissue module that can be fabricated to be substantially similar in anatomic internal and external shape as a target tissue. Some embodiments provide a composite tissue module having a plurality of layers, each of which simulate a different tissue (e.g., bone and cartilage of a joint). | 08-18-2011 |
| 20110201886 | REMOTE ENDOSCOPE HANDLE MANIPULATION - Systems and methods permit remote endoscope handle manipulation. This can include a control housing configured to removably attach to an endoscope. A manipulator, associated with the housing, can be configured to engage with a control device of the endoscope with the endoscope attached to the housing. An actuator, drivingly coupled with the manipulator, can be configured to move the manipulator to operate the control device with the endoscope attached to the housing. | 08-18-2011 |
| 20110185458 | FORCE, PRESSURE, OR STIFFNESS MEASUREMENT OR CALIBRATION USING GRAPHENE OR OTHER SHEET MEMBRANE - Force, pressure, or stiffness measurement or calibration can be provided, such as by using a graphene or other sheet membrane, which can provide a specified number of monolayers suspended over a substantially circular well. In an example, the apparatus can include a substrate, including a substantially circular well. A deformable sheet membrane can be suspended over the well. The membrane can be configured to include a specified integer number of one or more monolayers. A storage medium can comprise accompanying information about the suspended membrane or the substrate that, with a deflection displacement response of the suspended membrane to an applied force or pressure, provides a measurement of the applied force or pressure. | 07-28-2011 |
| 20110176763 | SYSTEMS AND METHODS FOR SENSING PROPERTIES OF A WORKPIECE AND EMBEDDING A PHOTONIC SENSOR IN METAL - Systems and methods for sensing properties of a workpiece and embedding a photonic sensor in metal are disclosed herein. In some embodiments, systems for sensing properties of a workpiece include an optical input, a photonic device, an optical detector, and a digital processing device. The optical input provides an optical signal at an output of the optical input. The photonic device is coupled to the workpiece and to the output of the optical input. The photonic device generates an output signal in response to the optical signal, wherein at least one of an intensity of the output signal and a wavelength of the output signal depends on at least one of thermal characteristics and mechanical characteristics of the workpiece. The optical detector receives the output signal from the photonic device and is configured to generate a corresponding electronic signal. The digital processing device is coupled to the optical detector and determines at least one of the thermal characteristics and mechanical the characteristics of the workpiece based on the electronic signal. | 07-21-2011 |
| 20110176051 | SYSTEM AND METHOD FOR FOCUSING OPTICS - In an apparatus and system for focusing optics an objective lens is configured to collect light from a region of an object to be imaged, said region having a feature with a known geometric characteristic, wherein the geometric characteristic is known before the feature is imaged by the optical device. A focusing sensor is configured to observe a shape of the feature and a splitter is configured to split the collected light into a first portion and a second portion, and directing said first portion through a weak cylindrical lens to the focusing sensor. A processor is configured to analyze the observed shape and determine whether the observed shape of the feature has a predetermined relationship to the known geometric characteristic and a mechanism is configured to autofocus the optical device by moving at least one of the objective lens and the object to be imaged in response to the analysis and determination of the processor. In some embodiments, the feature can be a fluorescent bead. In some embodiments, the splitting step can be accomplished with a dichroic mirror. In other embodiments, the splitting step can be accomplished with a partial mirror. In some embodiments, the known geometric characteristic of the feature can be substantially spherical, the observed shape can be an oval, and the predetermined relationship can be an allowable aspect ratio of the oval. In some embodiments, the allowable aspect ratio can be approximately one. | 07-21-2011 |
| 20110175750 | Decision Support Control Centers - The disclosed subject matter relates to an integrated decision support “cockpit” or control center for displaying, analyzing, and/or responding to, various events and contingencies that can occur within an electrical grid. | 07-21-2011 |
| 20110175099 | LITHOGRAPHIC METHOD OF MAKING UNIFORM CRYSTALLINE SI FILMS - Methods and devices are described relating to an electronic device positioned at a known location in a crystalline film including a crystalline semiconductor comprising a region of location controlled crystalline grains; a device located in the crystalline semiconductor film at a location that is defined relative to the location of the location controlled crystalline grains. The method includes irradiating at least a portion of a semiconductor film using two or more overlapping irradiation steps, wherein each irradiation step at least partially melts and laterally crystallizes a lithographically defined region the film to obtain a region of laterally grown crystalline grains having at least one long grain boundary that is perpendicular to the lateral growth length; identifying the location of at least one long grain boundary; and manufacturing an electronic device in the semiconductor film at a location that is defined relative to the location of the long grain boundary. | 07-21-2011 |
| 20110171607 | BIOPULP - Provided are methods for performing a dental, endodontic or root canal procedure on a mammalian tooth in need thereof. Also provided are matrices, materials or scaffolds suitable for insertion into a tooth pulp chamber. Additionally provided are uses of any of the above matrix, material or scaffolds in a dental, endodontic or root canal procedure. Further provided are uses of any of the above matrices, materials or scaffolds for the manufacture of a medicament for a dental, endodontic or root canal procedure. | 07-14-2011 |
| 20110171194 | METHODS AND COMPOSITIONS FOR INHIBITING ABAD/ABeta PROTEIN INTERACTION - This invention provides methods, compositions and articles of manufacture for inhibiting binding between Aβ protein and ABAD in cells. Uses of this invention include, for example, treating Alzheimer's disease; reducing free radical generation, DNA fragmentation, and cytochrome C release in cells; and preserving cell viability by preventing LDH release from a cell. | 07-14-2011 |
| 20110160543 | VOXEL-BASED METHODS FOR ASSESSING SUBJECTS USING POSITRON EMISSION TOMOGRAPHY - The subject matter disclosed herein relates to methods for diagnosing a neurological disorder in a subject. In certain aspects, the methods described herein involve determining one or more critical areas in the brain from PET data where two groups differ and measuring PET signal within determined critical areas in a new subject in order to assign risk or diagnosis. | 06-30-2011 |
| 20110157419 | APPARATUS AND METHOD FOR HIGH DYNAMIC RANGE IMAGING USING SPATIALLY VARYING EXPOSURES - Apparatus and methods are provided for obtaining high dynamic range images using a low dynamic range image sensor. The scene is exposed to the image sensor in a spatially varying manner. A variable-transmittance mask, which is interposed between the scene and the image sensor, imposes a spatially varying attenuation on the scene light incident on the image sensor. The mask includes light transmitting cells whose transmittance is controlled by application of suitable control signals. The mask is configured to generate a spatially varying light attenuation pattern across the image sensor. The image frame sensed by the image sensor is normalized with respect to the spatially varying light attenuation pattern. The normalized image data can be interpolated to account for image sensor pixels that are either under or over exposed to enhance the dynamic range of the image sensor. | 06-30-2011 |
| 20110157393 | LENSLESS IMAGING WITH CONTROLLABLE APERTURES - Embodiments of the present invention provide a lensless optical device for acquiring an image. The device can include a light attenuating layer having a plurality of elements, where transmittance of each of the plurality of elements is controllable, and an image detector disposed at a distance from the light attenuating layer, the image detector configured to acquire an image with light that passes through the light attenuating layer. The device also can include a light attenuating layer controller configured to simultaneously control transmittance of each of the plurality of elements independent of each other. Methods of detecting and tracking an object in a scene are also disclosed. | 06-30-2011 |
| 20110147344 | DEVICES AND METHODS FOR PROVIDING STIMULATED RAMAN LASING - Devices and methods for providing stimulated Raman lasing are provided. In some embodiments, devices include a photonic crystal that includes a layer of silicon having a lattice of holes and a linear defect that forms a waveguide configured to receive pump light and output Stokes light through Raman scattering, wherein the thickness of the layer of silicon, the spacing of the lattice of holes, and the size of the holes are dimensioned to provide Raman lasing. In some embodiments, methods include forming a layer of silicon, and etching the layer of silicon to form a lattice of holes with a linear defect that forms a waveguide configured to receive pump light and output Stokes light through Raman scattering, wherein the thickness of the layer of silicon, the spacing of the lattice of holes, and the size of the holes are dimensioned to provide Raman lasing. | 06-23-2011 |
| 20110145232 | SYSTEM AND METHOD FOR DYNAMICALLY AND INTERACTIVELY SEARCHING MEDIA DATA - The disclosed subject matter is directed to systems and methods for searching a database of media content wherein the user can dynamically and interactively perform searches and navigate search results. One or more search anchors are received, and at least one of the search anchors is associated with an anchor cell on a navigation map. One or more documents assigned to at least one cell on the navigation map can be determined, and the cells are populated with search results based at least in part on the search anchors. At least one of the documents is then displayed to a user. | 06-16-2011 |
| 20110136225 | BIOREACTOR, DEVICES, SYSTEMS AND METHODS - Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a CO | 06-09-2011 |
| 20110124188 | METHODS OF FABRICATING ELECTRODES AND USES THEREOF - The present invention relates to methods for fabricating nanoscale electrodes separated by a nanogap, wherein the gap size may be controlled with high precision using a self-aligning aluminum oxide mask, such that the gap width depends upon the thickness of the aluminum oxide mask. The invention also provides methods for using the nanoscale electrodes. | 05-26-2011 |
| 20110121857 | ASYNCHRONOUS DIGITAL CIRCUITS INCLUDING ARBITRATION AND ROUTING PRIMITIVES FOR ASYNCHRONOUS AND MIXED-TIMING NETWORKS - Asynchronous digital circuits are described, including arbitration and routing primitives for asynchronous and mixed-timing networks. An asynchronous arbitration primitive has two data inputs and one data output. A mutual exclusion element is used to select the first-arriving data request from one of the two inputs to the output. A asynchronous routing primitive has one data input and two data outputs. The incoming data is routed to one of the two outputs based on a routing bit accompanying the data. The primitives use handshaking with request and acknowledge signals to ensure that data is passed when neighboring circuits are ready to receive or send data. | 05-26-2011 |
| 20110121306 | Systems and Methods for Non-Periodic Pulse Sequential Lateral Solidification - The disclosed systems and method for non-periodic pulse sequential lateral solidification relate to processing a thin film. The method for processing a thin film, while advancing a thin film in a selected direction, includes irradiating a first region of the thin film with a first laser pulse and a second laser pulse and irradiating a second region of the thin film with a third laser pulse and a fourth laser pulse, wherein the time interval between the first laser pulse and the second laser pulse is less than half the time interval between the first laser pulse and the third laser pulse. In some embodiments, each pulse provides a shaped beam and has a fluence that is sufficient to melt the thin film throughout its thickness to form molten zones that laterally crystallize upon cooling. In some embodiments, the first and second regions are adjacent to each other. In some embodiments, the first and second regions are spaced a distance apart. | 05-26-2011 |
| 20110119031 | METHOD OF ADAPTIVE DATA ACQUISITION - Methods for adaptive data acquisition are disclosed herein. In one aspect, methods for adaptive data acquisition include performing a first sensing method on a signal having a plurality of components to determine the likelihood that a component is not a relevant signal component, retaining a portion of the signal components sensed using the first sensing method that are above a first threshold, performing a second sensing method on the signal components retained above a first threshold to determine the likelihood that a component is not a relevant signal component, wherein the second sensing method is more reliable than the first sensing method at determining the likelihood that a component is not a relevant signal component, and retaining a portion of the signal components sensed using the second sensing method that are above a second threshold. | 05-19-2011 |
| 20110117099 | INHIBITING STAPHYLOCOCCUS EPIDERMIDIS INFECTIONS - The invention relates to | 05-19-2011 |
| 20110116551 | APPARATUS AND METHODS FOR PROCESSING COMPRESSION ENCODED SIGNALS - Apparatus and methods for processing compression encoded signals are provided. In some embodiments, a signal processing method is provided that includes receiving a subband of a compression encoded signal at a subband processor, generating envelope information regarding the subband of the compression encoded signal to provide changes in the dynamic range of the compression encoded signal for fixed-point digital signal processing, processing the compression encoded signal with a fixed-point companding digital signal processor using the envelope information, and producing a processed compression encoded signal at the output of the subband processor. | 05-19-2011 |
| 20110116049 | SYSTEMS AND METHODS FOR DISPLAYING THREE-DIMENSIONAL IMAGES - Systems and methods for displaying three-dimensional (3D) images are described. In particular, the systems can include a display block made from a transparent material with optical elements three-dimensionally disposed therein. Each optical element becomes luminous when illuminated by a light ray. The systems can also include a computing device configured to generate two-dimensional (2D) images formatted to create 3D images when projected on the display block, by a video projector coupled to the computing device. The video projector is configured to project the 2D images on the block to create the 3D images by causing a set of the passive optical elements to become luminous. Various other systems and methods are described for displaying 3D images. | 05-19-2011 |
| 20110108843 | COLLECTIONS OF LATERALLY CRYSTALLIZED SEMICONDUCTOR ISLANDS FOR USE IN THIN FILM TRANSISTORS - Collections of laterally crystallized semiconductor islands for use in thin film transistors and systems and methods for making same are described. A display device includes a plurality of thin film transistors (TFTs) on a substrate, such that the TFTs are spaced apart from each other and each include a channel region that has a crystalline microstructure and a direction along which a channel current flows. The channel region of each of the TFTs contains a crystallographic grain that spans the length of that channel region along its channel direction. Each crystallographic grain in the channel region of each of the TFTs is physically disconnected from and crystallographically uncorrelated with each crystallographic grain in the channel region of each adjacent TFT. | 05-12-2011 |
| 20110107098 | Methods and Systems for Controlling Traffic on a Communication Network - Methods and systems for controlling traffic on a communication network are provided. In accordance with some embodiments, methods for controlling traffic on a communication network are provided, the methods comprising—receiving, at a processor in a receiver, a query message for permission to send a data flow to the receiver; sending a permission message from the receiver; defecting that at least one of a message and a data packet being sent to the receiver has been dropped; and causing the path for sending the data flow to be changed. | 05-05-2011 |
| 20110105982 | FLUID SEPARATION DEVICES, SYSTEMS AND METHODS - A membraneless separation device can be applied to a variety of treatments, such as the ultrafiltration of blood for a patient with end stage renal disease. An ultrafiltration device can include a membraneless separation device, which separates an incoming blood flow into a substantially cytoplasmic body-free plasma flow and remaining fraction, and a dialysate-free second stage, which selectively removes excess fluid, toxins and other substances from the plasma flow and returns the processed plasma to the membraneless separation device. A treatment protocol can include ultrafiltering blood of a patient using the ultrafiltration device and performing a secondary treatment on the blood of the patient at a reduced frequency compared to the ultrafiltering. The membraneless separation device can also be applied to treatment, analysis, and/or exchange of plasma from blood, or combined with conventional dialyzers to perform dialysis on a cytoplasmic body-free plasma fraction. | 05-05-2011 |
| 20110104396 | SUBSTRATE LASER OXIDE REMOVAL PROCESS FOLLOWED BY ELECTRO OR IMMERSION PLATING - Method of ablating the surface of a substrate including providing a dry substrate and an electrolyte source, ablating the surface of the dry substrate to at least partially remove a native oxide layer, and immersing the ablated dry substrate in the electrolyte source, in which the dry substrate is ablated prior to being introduced into the electrolyte source. Also provided is a method of ablating the surface of a substrate that includes providing a dry substrate and an electrolyte, depositing a portion of the electrolyte on the substrate at a thickness of less than 10 microns and ablating the surface of the substrate with the electrolyte applied thereon. System for use in the ablation of the surface of a substrate are also provided. | 05-05-2011 |
| 20110087349 | Systems, Methods, and Media for Identifying Matching Audio - System, methods, and media that: receive a first piece of audio content; identify a first plurality of atoms that describe at least a portion of the first piece of audio content using a Matching Pursuit algorithm; form a first group of atoms from at least a portion of the first plurality of atoms, the first group of atoms having first group parameters; form at least one first hash value for the first group of atoms based on the first group parameters; compare the at least one first hash value with at least one second hash value, wherein the at least one second hash value is based on second group parameters of a second group of atoms associated with a second piece of audio content; and identify a match between the first piece of audio content and the second piece of audio content based on the comparing. | 04-14-2011 |
| 20110086797 | CONTROL OF SPORE GERMINATION - Provided are compositions and methods for treating bacterial infections. It is demonstrated herein that bacteria cell wall materials stimulate germination of spores of Gram-positive bacteria, and that such activity requires Ser/Thr kinase PrkC. By modulating one or both, spores (which can be antibiotic resistant) can be stimulated or inhibited from germination, which can be exploited in various methods of therapeutic treatment. Also provided is a method of modulating germination of a spore of a Gram-positive bacterium. Also provided is a method of decontaminating an environment. | 04-14-2011 |
| 20110076384 | SYSTEM AND METHOD FOR MAKING BIOMATERIAL STRUCTURES - A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is positioned along the support structure. The at least one applicator forms a biomaterial fiber by applying shear force to the biomaterial solution and delivering the biomaterial fiber to the support structure. A controller causes relative movement between the support structure and the at least one applicator, and the biomaterial fiber is arranged on the support structure according to the relative movement to form the biomaterial device. The biomaterial may be silk fibroin which may be wound onto a reciprocating and rotating mandrel. Control over the properties of the biomaterial device is achieved through appropriate selection of material processing, winding strategy, and post-winding processing. | 03-31-2011 |
| 20110071124 | Compounds that Inhibit Production of sAPPB and AB and Uses Thereof - The present invention relates to compounds with activity as inhibitors of sAPPβ and Aβ production, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease and pharmaceutical compositions containing such candidate compounds. | 03-24-2011 |
| 20110066160 | SYSTEMS AND METHODS FOR INSERTING STEERABLE ARRAYS INTO ANATOMICAL STRUCTURES - Systems and Methods are provided for inserting a steerable array into an anatomical structure of the body. The system includes an insertion module for holding a proximal end of the steerable array and a force sensor configured to detect force on the steerable array and to produce force information. The system includes a position sensor configured to detect a position of the insertion module and to produce position information, the position information including a lateral position along an insertion axis and a first approach angle relative to a first reference axis. The system further includes a processor configured to receive the force information from the force sensor and the position information from the position sensor. The processor outputs performance information to a user. The performance information includes an indication of a first differential approach angle relative to an insertion path plan. | 03-17-2011 |
| 20110066097 | SYSTEMS AND METHODS OF MICROFLUIDIC MEMBRANELESS EXCHANGE USING FILTRATION OF EXTRACTION OUTLET STREAMS - A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration. | 03-17-2011 |
| 20110062422 | Systems And Methods For Forming Defects On Graphitic Materials And Curing Radiation-Damaged Graphitic Materials - Systems and methods are disclosed herein for forming defects on graphitic materials. The methods for forming defects include applying a radiation reactive material on a graphitic material, irradiating the applied radiation reactive material to produce a reactive species, and permitting the reactive species to react with the graphitic material to form defects. Additionally, disclosed are methods for removing defects on graphitic materials. | 03-17-2011 |
| 20110062083 | SYSTEMS AND METHODS OF MICROFLUIDIC MEMBRANELESS EXCHANGE USING FILTRATION OF EXTRACTION OUTLET STREAMS - A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration. | 03-17-2011 |
| 20110059113 | GAB2 AMPLIFICATION IN MELANOMA - Provided herein are methods of detecting or inhibiting melanoma growth based on Gab2 protein expression. Gab2 protein was found to be either amplified and/or overexpressed in melanoma. Gab2 protein expression correlated with clinical melanoma progression and higher levels of expression were seen in metastatic melanomas compared to primary melanoma and melanocytic nevi. Over-expression of Gab2 potentiates, whereas silencing of Gab2 reduces, migration and invasion of melanoma cells. Gab2 mediated hyperactivation of Akt signaling in the absence of growth factors and inhibition of the PI3K-Akt pathway decreased Gab2-mediated tumor cell migration and invasive potential. Gab2 over-expression resulted in enhanced tumor growth and metastatic potential in vivo. These results demonstrate a previously undefined role for Gab2 in melanoma tumor progression and metastasis. | 03-10-2011 |
| 20110056884 | SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICE - The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid. | 03-10-2011 |
| 20110052192 | SYSTEMS AND METHODS FOR STORING OPTICAL DATA - An optical data storage system and method of use thereof are presented. The optical data storage system includes one or more optical buffer modules connected in series. Each optical buffer module includes a cross connect. Each cross connect is connected, by a pair of inputs and outputs, to an optical data storage unit, for example, a fiber delay line, by a pair to either an optical packet network or a cross connect of a first adjacent buffer module in the series, and by a pair to a cross connect of a second adjacent buffer module in the series. The buffer module also includes a read signal output line which is connected to a read signal input line of the second adjacent buffer module for transmitting a read signal. A control module within each buffer module directs the passage of data through the cross connect. | 03-03-2011 |
| 20110042201 | In situ Plating And Soldering Of Materials Covered With A Surface Film - The disclosed subject matter provides systems and methods for etching and/or metal plating of substrate materials. An exemplary method in accordance with the disclosed subject matter for metal-plating or etching a substrate includes submerging portions of the substrate in a first bath of chemical solution, performing in-situ laser ablation of the substrate to achieve an immersion plated pattern with a first cation, plating-up the immersion plated pattern with the first cation in the first bath, and plating-up the immersion plated pattern with a second cation in a second bath. The same or another exemplary method can utilize a reel-to-reel system. The plating-up can begin after patterning by immersion plating is complete. Further, a single plating pattern can be used to define a pattern and the same bath can be used to plate the immersion pattern, thereby achieving a uniform thickness of the pattern. | 02-24-2011 |
| 20110041857 | FIBROBLAST DERIVED STEM CELLS - The present invention provides methods and compositions relating to the production of stem cells, derived from dedifferentiated fibroblasts, and the use of such stem cells for treatment of a variety of different disorders and conditions. The invention is based on the surprising discovery that a population of stem cells, capable of differentiating into a variety of different cell types, can be generated by culturing fibroblasts under selective culture conditions. | 02-24-2011 |
| 20110028341 | METHODS, DEVICES, AND SYSTEMS FOR CHEMILUMINESCENCE-BASED MICROFLUIDIC CELL COUNTING - A chemiluminescence-based detection system and method for counting blood cells by capturing and isolating target blood cells flowing through a microfluidic chip and detecting light emitted by the captured target blood cells. | 02-03-2011 |
| 20110025710 | SYSTEMS AND METHODS FOR IMAGE ARCHEOLOGY - Systems and methods are described for determining manipulation history among a plurality of images. The described techniques include selecting a pair of images from the plurality of images, detecting one or more manipulations operable to transform one of the images to the other, and based on the manipulations detected, determining a parent-child relationship between the pair or pairs of images. The described techniques can further include repeating the selecting two images, detecting manipulations, and determining the parent-child relationship for each pairs of images in the plurality of images, constructing a visual migration map for the images, and presenting the visual migration map in a user readable format. | 02-03-2011 |
| 20110021966 | SYSTEMS, METHODS, AND DEVICES FOR BLOOD TREATMENT - A blood treatment device provides a photopheresis treatment using a microfluidic separation channel to separate blood components into layers The layering caused by laminar flow in the microfluidic separation channel allows light to be projected through plasma onto leukocytes without hindrance by erythrocytes | 01-27-2011 |
| 20110020452 | PROGENITOR CELL REPLICATION AND DIFFERENTIATION IN 3D - The present invention is directed to a new approach towards in situ differentiation of tissue progenitor cells, without the coventional requirements of weeks of cellular manipulation and treatment. Such approach circumvents the need for 2D culturing and differentiation of tissue progenitor cells before implanting in a 3D biocompatible matrix, thus providing convenience, cost savings, and time savings. One aspect of the invention provides an engineered tissue composition comprising substantially undifferentiated tissue progenitor cells in a biphasic matrix material, along with growth factors or encapsulated growth factors. Another aspect of the invention includes methods for making the compositions described herein. Another aspect of the invention includes methods of therapeutic treatment using the compositions described herein. | 01-27-2011 |
| 20110018964 | SYSTEMS AND METHODS FOR PANORAMIC IMAGING - Systems and methods for panoramic imaging are disclosed herein. An exemplary system of the disclosed subject matter for panoramic imaging includes a fisheye lens, a mirror optically coupled to the fisheye lens, and a detector for capturing light incident on the fisheye lens and reflected from the mirror. In some embodiments, the mirror is a spherical mirror. In some embodiments, the mirror is positioned coaxially with regard to the fisheye lens. In some embodiments, the system is further configured to satisfy the following conditions that the upper angle of a desired field of view is equal to the upper angle of a field of view of the fisheye lens, the lower angle of the desired field of view is less than or equal to the lower angle of a field of view of the mirror, and the angle of overlap between the field of view of the mirror and the field of view of the fisheye lens is equal to the difference between the lower angle of the field of view of the fisheye lens and the upper angle of the field of view of the mirror. | 01-27-2011 |
| 20110017979 | HIGH-PERFORMANCE GATE OXIDES SUCH AS FOR GRAPHENE FIELD-EFFECT TRANSISTORS OR CARBON NANOTUBES - An apparatus or method can include forming a graphene layer including a working surface, forming a polyvinyl alcohol (PVA) layer upon the working surface of the graphene layer, and forming a dielectric layer upon the PVA layer. In an example, the PVA layer can be activated and the dielectric layer can be deposited on an activated portion of the PVA layer. In an example, an electronic device can include such apparatus, such as included as a portion of graphene field-effect transistor (GFET), or one or more other devices. | 01-27-2011 |
| 20110015739 | SYSTEMS AND METHODS FOR FORMING PATTERNED EXTRACELLULAR MATRIX MATERIALS - An extracellular matrix (ECM)-based scaffold suitable for artificial skin as well as other structures can be formed using a bioreactor fabricated with a pattern that introduces desired structural features, on the microscale and/or nanoscale, to ECM-precursors gelled in the bioreactor. The bioreactor can produce a finely patterned scaffold—over clinically relevant size scales—sufficiently robust for routine handling. Preformed ECM-based scaffolds can also have microscale and/or nano-scale structural features introduced into a surface thereof. ECM-based scaffolds may be formed with well-defined structural features via microetching and/or remodeling via ‘contact degradation.’ A surface-activated pattern can be used to degrade the ECM-based scaffold at contact regions between the pattern and the ECM. The produced ECM-based scaffolds can have structures of dimensions conducive to host tissue ingrowth while preserving the fibrous structure and ligand density of natural ECMs. | 01-20-2011 |
| 20110002894 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HEART TISSUE DEGENERATION AND USES THEREOF - The present invention provides compositions useful for cardiac therapy comprising a cyclin-associated agent. The present invention also provides kits for use in delivering a cyclin-associated agent to cardiac cells in a subject, comprising the composition of the present invention and a catheter. The present invention additionally provides a methods for enhancing cardiac function; promoting regeneration of cardiac tissue; inducing endogenous myocardial regeneration; and preventing or treating heart failure in a subject in need thereof by augmenting cyclin in cells. | 01-06-2011 |
| 20100331858 | SYSTEMS, DEVICES, AND METHODS FOR ROBOT-ASSISTED MICRO-SURGICAL STENTING - Systems, devices, and methods for robot-assisted microsurgical stenting are described herein. In some embodiments a tele-robotic microsurgical system for eye surgery include: a tele-robotic master and a slave hybrid-robot; wherein the tele-robotic master has at least one master slave interface controlled by a medical professional; wherein the slave hybrid-robot has at least one robotic arm attached to a frame releasably attached to a patient's head; wherein the at least one robotic arm has a parallel robot and a serial robot; and wherein the serial robot includes a stenting unit which includes a support tube, a pre-bent tube mounted within the support tube and a guide wire extending from the support tube for carrying a stent and for piercing a blood vessel. | 12-30-2010 |
| 20100305696 | HYBRID SOFT TISSUE IMPLANTS FROM PROGENITOR CELLS AND BIOMATERIALS - Provided are hybrid soft tissue constructs comprising a core material, a biomaterial matrix and mammalian cells. Also provided are methods of augmenting or reconstructing a soft tissue of a mammal. Additionally, methods of forming a hybrid soft tissue construct are provided. The use of the above constructs for augmenting or reconstructing a soft tissue of a mammal are further provided. Additionally provided is the use of the above constructs for the manufacture of a medicament for augmenting or reconstructing a soft tissue of a mammal. | 12-02-2010 |
| 20100303767 | METHODS FOR COMPACT AGGREGATION OF DERMAL CELLS - The invention provides for a method for aggregating dermal papilla cells or dermal sheath cells or a combination thereof, the method comprising: growing dermal papilla cells or dermal sheath cells or a combination thereof in suspension culture; and contacting the culture with an effective amount of an enzyme, wherein a substrate of the enzyme is an extracellular matrix molecule in the suspension culture, so as to aggregate dermal papilla cells or dermal sheath cells. The culture may be a hanging drop culture and the enzyme may be a hyaluronidase. | 12-02-2010 |
| 20100303101 | REAL-TIME TIME ENCODING AND DECODING MACHINES - Methods for decoding a signal encoded by a Time Encoding Machine (TEM) include defining a plurality of time-windows, each time-window corresponding to a portion of a TEM-encoded signal and made up of a plurality of trigger values, at least two of the time-windows overlapping, decoding each of the time-windows using a Time Decoding Machine (TDM) to generate a decoded time-window, and stitching the decoded time-windows together to generate a TEM-decoded signal. | 12-02-2010 |
| 20100300899 | Active CMOS Sensor Array For Electrochemical Biomolecular Detection - Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enhancing portability for point-of-care applications, while enabling high-throughput, highly-parallel analysis. One embodiment includes a four-by-four active sensor array for multiplexed electrochemical biomolecular detection in a standard 0.25-μm CMOS process. Integrated potentiostats, including control amplifiers and dual-slope ADCs, stimulate the electrochemical cell and detect the current flowing through on-chip gold electrodes at each sensor site resulting from biomolecular reactions occurring on the chip surface. Post-processing techniques for fabricating biologically-compatible surface-electrode arrays in CMOS that can withstand operation in harsh electrochemical environments are described. Demonstrations showing example operation of the active CMOS array for biomolecular detection include cyclic voltammetry of a reversible redox species, DNA probe density characterization, and quantitative and specific DNA hybridization detection in real time. | 12-02-2010 |
| 20100292569 | SYSTEMS AND METHODS FOR DYNAMIC IMAGING OF TISSUE USING DIGITAL OPTICAL TOMOGRAPHY - A methods for imaging tissue using diffuse optical tomography with digital detection includes directing at the tissue a plurality of amplitude modulated optical signals from a plurality of optical signal sources illuminating the tissue at a plurality of locations; detecting a resulting plurality of attenuated optical signals exiting the tissue to obtain a plurality of analog signals containing diffuse optical tomographic information; converting the analog signals into digital signals; recovering the tomographic information from the digital signals using a digital signal processor-based detection module that performs digital detection, wherein the detection module includes a master digital signal processing subsystem and at least one slave digital signal processing subsystem that processes at least a portion of the digital signals and the master digital signal processing subsystem controls the at least one slave digital signal processing subsystem; and transmitting the recovered tomographic information in digital form to a host computer. | 11-18-2010 |
| 20100284904 | METHODS AND SYSTEMS FOR GENERATING HYDROGEN AND SEPARATING CARBON DIOXIDE - Methods and systems for generating hydrogen and separating carbon dioxide from a feed stream including hydro-carbons and water are disclosed. In some embodiments, the method includes the following: providing a catalytic chamber including a monolithic structure having surfaces coated with carbon dioxide adsorbing materials and one or more washcoated layers of combined steam reforming, water gas shift, and combustion catalysts; directing the feed stream into said catalytic chamber; controlling the feed stream so that it has a temperature range that allows the reactive generation of carbon dioxide and hydrogen gas but does not cause substantial development of coke between hydrocarbons in the feed stream and said surfaces of said monolithic structure; and adsorbing said carbon dioxide generated by heating the feed stream, wherein said carbon dioxide is adsorbed onto carbon dioxide adsorbing materials on said surfaces of said monolithic structure. | 11-11-2010 |
| 20100281542 | Systems and Methods for Correlating and Distributing Intrusion Alert Information Among Collaborating Computer Systems - Systems and methods provide an alert correlator and an alert distributor that enable early signs of an attack to be detected and rapidly disseminated to collaborating systems. The alert correlator utilizes data structures to correlate alert detections and provide a mechanism through which threat information can be revealed to other collaborating systems. The alert distributor uses an efficient technique to group collaborating systems and then pass data between certain members of those groups according to a schedule. In this way data can be routinely distributed without generating excess traffic loads. | 11-04-2010 |
| 20100281541 | Systems and Methods for Correlating and Distributing Intrusion Alert Information Among Collaborating Computer Systems - Systems and methods for correlating and distributing intrusion alert information among collaborating computer systems are provided. These systems and methods provide an alert correlator and an alert distributor that enable early signs of an attack to be detected and rapidly disseminated to collaborating systems. The alert correlator utilizes data structures to correlate alert detections and provide a mechanism through which threat information can be revealed to other collaborating systems. The alert distributor uses an efficient technique to group collaborating systems and then pass data between certain members of those groups according to a schedule. In this way data can be routinely distributed without generating excess traffic loads. | 11-04-2010 |
| 20100278798 | METHODS AND SYSTEMS FOR FORMING BIOCOMPATIBLE MATERIALS - Methods and systems forming biocompatible materials are disclosed herein. Forming a biocompatible material may include contacting a liquid, having a linking material, with an adjoining material having embedded therein a nucleating material that causes the linking material to nucleate and grow into the liquid. After a time sufficient to cause the linking material to grow substantially from the nucleating material into a space occupied by the liquid, the liquid may be solidified to form a solid such that the linking material secures the solid to the adjoining material. | 11-04-2010 |
| 20100273720 | Protective Complement Proteins and Age-Related Macular Degeneration - Methods for identifying a subject at risk for developing AMD are disclosed. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material. Therapeutic compositions and methods are also provided for delaying the progression or onset of the development of AMD in a subject, including treating a subject having signs and/or symptoms of AMD or who has been diagnosed with AMD. | 10-28-2010 |
| 20100270557 | METHODS OF PRODUCING HIGH UNIFORMITY IN THIN FILM TRANSISTOR DEVICES FABRICATED ON LATERALLY CRYSTALLIZED THIN FILMS - Methods of producing high uniformity in thin film transistor devices fabricated on laterally crystallized thin films are described. A thin film transistor (TFT) includes a channel area disposed in a crystalline substrate, which has grain boundaries that are approximately parallel with each other and are spaced apart with approximately equal spacings. The shape of the channel area includes a non-equiangular polygon that has two opposing side edges that are oriented substantially perpendicular to the grain boundaries. The polygon further has an upper edge and a lower edge. At least a portion of each of the upper and lower edges is oriented at a tilt angle with respect to the grain boundaries. The tilt angles are selected such that the number of grain boundaries covered by the polygon is independent of the location of the channel area within the crystalline substrate. | 10-28-2010 |
| 20100266126 | FRIEND OR FOE DETECTION - An identification friend or foe (IFF) system and method can covertly identify an object as friend or foe (FoF). An encoded illumination signal can be calculated using a detected ambient signal and an identification (ID) signal and emitted. The encoded illumination signal can be detected by analyzing a detected ambient signal and decoded using a specified key. | 10-21-2010 |
| 20100260772 | METHODS FOR TREATING OR PREVENTING DISEASES ASSOCIATED WITH LOW BONE MASS - Methods of treating or preventing diseases associated with low bone mass in a mammal in need of such treatment or prevention comprising administering to the mammal a therapeutically effective amount of an agent that increases tryptophan hydroxylase 2 activity or of an agonist of the brain serotonin HT2C receptor. Diseases associated with low bone mass include osteoporosis, osteopenia, Paget's disease, osteomalacia, and renal osteodystrophy. | 10-14-2010 |
| 20100248099 | SOFTWARE-CONTROLLED MASKLESS OPTICAL LITHOGRAPHY USING FLUORESCENCE FEEDBACK - A software-controlled maskless optical lithography system uses fluorescence feedback to control an aspect of the lithography, such as light source dose, wavelength, or flashing instances or duration, spatial light modulator (SLM) pattern, an optics parameter, a beamsplitter control parameter, or movement or positioning of a stage carrying a target workpiece, such as a semiconductor wafer. | 09-30-2010 |
| 20100245549 | INSERTABLE SURGICAL IMAGING DEVICE - A body-insertable imaging device includes a first camera that comprises a first image sensor and a first lens to pass incident light onto the first image sensor, a control interface to receive a remotely generated control signal, and an actuator communicatively coupled to the control interface and configured to support the camera and manipulate the camera about a pan axis, a tilt axis, and along a zoom direction in response to the control signal while the camera and actuator are within a body cavity, wherein the zoom direction extends out from a distal end of the body-insertable camera. | 09-30-2010 |
| 20100240581 | SELECTIVE PROTEASOME INHIBITORS FOR TREATING DIABETES - Methods of modulating chronic low-grade inflammation are provided. More particularly, methods of treating diabetes, such as for example, type-2 diabetes mellitus, in a mammal by administering an effective amount of a selective proteasome inhibitor are provided. Also provided are unit dosage forms of such inhibitors. | 09-23-2010 |
| 20100225824 | Multi-Input Multi-Output Time Encoding And Decoding Machines - Methods and systems for encoding and decoding signals using a Multi-input Multi-output Time Encoding Machine (TEM) and Time Decoding Machine are disclosed herein. | 09-09-2010 |
| 20100223332 | SYSTEMS AND METHODS FOR IMPLEMENTING RELIABLE NEIGHBORCAST PROTOCOL - Methods and systems for vehicle-to-vehicle communications where vehicles can communicate one or more of speed, position, direction, acceleration and state in order to coordinate or control their operation are disclosed herein. In some embodiments of the disclosed subject matter, methods for vehicle-to-vehicle communications where vehicles can communicate one or more of speed, position and state in order to coordinate or control their operation. An exemplary method includes creating moving broadcasting groups which groups can move with the flow of traffic, adjust the span of the group and maintain minimum overlap size between adjacent broadcasting groups, combining two or more vehicles within one or more broadcasting groups, within some specified distance into neighborhoods, transmitting information about one or more of speed, position and state of vehicles in the neighborhood to the other vehicles in said neighborhood; receiving information about speed, position and state by vehicles in the neighborhood from the other vehicles in said neighborhood, filtering out duplicate information and information received from vehicles that are not in the same neighborhood, providing that two or more vehicles in the same neighborhood have substantially continuous communication capacity by maintaining the size of overlap between adjacent neighborhoods, avoiding delays in entering the new neighborhood by extending the overlap size, and utilizing one or more guarantees provided by an underlying reliable broadcast communication layer by transferring said guarantees to corresponding one or more neighborhoods. | 09-02-2010 |
| 20100221723 | EARLY DETECTION OF CANCER BY METHYLATED DNA IN BLOOD - This invention relates to early detection of cancer by detecting methylated DNA in blood. In one embodiment, there is provided a method of predicting the occurrence of hepatocellular carcinoma in a subject, comprising the steps of preparing DNA samples from blood samples of the subject; and determining methylation status of a group of genes comprising RASSF1A, p16 and p15, wherein hypermethylation of these genes as compared to normal control samples indicates the subject is likely to develop hepatocellular carcinoma in the future. | 09-02-2010 |
| 20100213467 | DIRECT BANDGAP SUBSTRATES AND METHODS OF MAKING AND USING - An indirect bandgap thin film semiconductor circuit can be combined with a compound semiconductor LED such as to provide an active matrix LED array that can have high luminous capabilities such as for a light projector application. In another example, a highly efficient optical detector is achievable through the combination of indirect and direct bandgap semiconductors. Applications can include display technologies, light detection, MEMS, chemical sensors, or piezoelectric systems. An LED array can provide structured illumination, such as for a light and pattern source for projection displays, such as without requiring spatial light modulation (SLM). An example can combine light from separate monolithic light projector chips, such as providing different component colors. An example can provide full color from a single monolithic light projector chip, such as including selectively deposited phosphors, such as to contribute individual component colors to an overall color of a pixel. | 08-26-2010 |
| 20100204258 | METHODS AND COMPOSITIONS FOR MODULATING INSULIN SECRETION AND GLUCOSE METABOLISM - The present invention relates to methods and compositions for treating or ameliorating the effects of diabetes. In addition, the present invention relates to methods and compositions for treating or preventing hyperglycemia, as well as modulating monoamine levels, islet β-cell insulin secretion, insulin and/or glucagon levels in a patient. In certain preferred embodiments, such methods include administering to a patient an effective amount of a vesicular monoamine transporter type 2 (VMAT2) antagonist, such as tetrabenazine (TBZ), dihydrotetrabenazine (DTBZ), tetrahydroberberine (THB), reserpine, emetine, Compound 6, or enantiomers, optical isomers, diastereomers, N-oxides, crystalline forms, hydrates, metabolites or pharmaceutically acceptable salts thereof. | 08-12-2010 |
| 20100198131 | SYSTEMS AND METHODS OF MICROFLUIDIC MEMBRANELESS EXCHANGE USING FILTRATION OF EXTRACTION OUTLET STREAMS - A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration. | 08-05-2010 |
| 20100196441 | USES OF IMMUNOLOGICALLY MODIFIED SCAFFOLD FOR TISSUE PREVASCULARIZATION CELL TRANSPLANTATION - This invention provides method of making and using of a porous 3 dimensional cyclic RGD peptide-modified alginate scaffold that can be loaded with different cell types and/or growth factors for implantation at sites of tissue damage to promote tissue regeneration. The cyclic RGD peptide promotes vascular formation of the host tissue, cell binding and survival of seeded cells. Scaffolds with growth factors but without cells can also be implanted to create a vascular bed in which cells are transplanted at a later time point. | 08-05-2010 |
| 20100174670 | DATA CLASSIFICATION AND HIERARCHICAL CLUSTERING - Apparatus, systems, and methods can operate to provide efficient data clustering, data classification, and data compression. A method comprises training set of training instances can be processed to select a subset of size-1 patterns, initialize a weight of each size-1 pattern, include the size-1 patterns in classes in a model associated with the training set, and then include a set of top-k size-2 patterns in a way that provides an effective balance between local, class, and global significance patterns. A method comprises processing a dataset to compute an overall significance value of each size-2 pattern in each instance in the dataset, sort the size-2 patterns, and select the top-k size-2 patterns to be represented in clusters, which can be refined into a clustered hierarchy. A method comprises creating an uncompressed bitmap, reordering the bitmap, and compressing the bitmap. Additional apparatus, systems, and methods are disclosed. | 07-08-2010 |
| 20100172848 | SKIN AND SURFACE DISINFECTANT COMPOSITIONS CONTAINING BOTANICALS - The present invention relates to a skin or surface disinfectant composition with broad spectrum antimicrobial activity comprising one or more essential oil (and/or one or more component thereof) and one or more fruit acid. The compositions of the invention may be used as non-toxic alternatives to conventional disinfectants or may be added to other antimicrobial agents to enhance their activity. The invention provides effective alternatives to harsher products which may be particularly useful in personal care and household products and where children and/or pet exposure may be a concern. | 07-08-2010 |
| 20100172847 | ANTIMICROBIAL COMPOSITIONS CONTAINING LOW CONCENTRATIONS OF BOTANICALS - The present invention relates to a preservative or antimicrobial compositions with broad spectrum antimicrobial activity comprising low concentrations of essential oil (and/or one or more component thereof) and a botanical extract in synergistic combination with a fruit acid and alkanediol, and optionally a solvent. The compositions of the invention may be used in personal care products such as creams or soap products. | 07-08-2010 |
| 20100168586 | Optical imaging or spectroscopy systems and methods - Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM). | 07-01-2010 |
| 20100168532 | SYSTEMS AND METHODS FOR MEASURING BRAIN ACTIVITY - A device for measuring intracortical brain activity of a subject is provided. The device includes a support member configured for intracranial insertion in the subject. The device comprises a plurality of electrodes are positioned in an electrode region of the support member, which is configured to traverse the cerebral cortex of the subject when the support member is inserted intracranially in the subject. In certain embodiments, the device further comprises drainage region positioned on the support member such that two or more electrodes in the electrode region contact the cerebral cortex of the subject when the drainage region of the support member is in fluid contact with cerebrospinal fluid in the brain ventricle of the subject. In certain embodiments, the device further comprises a detector or probe for monitoring an additional brain parameter. | 07-01-2010 |
| 20100163412 | ON-DEMAND MICROFLUIDIC DROPLET OR BUBBLE GENERATION - Microfluidic systems and methods can dispense single or multiple fluid particles (such as a gas or other fluid bubble) or an encapsulated particle (e.g., a bead or biological cell) into a microchannel. | 07-01-2010 |
| 20100157834 | SYSTEMS AND METHODS FOR COMPUTING DATA TRANSMISSION CHARACTERISTICS OF A NETWORK PATH BASED ON SINGLE-ENDED MEASUREMENTS - Systems and methods for computing data transmission characteristics of a network path are disclosed. In some embodiments, the network path has a sending host, at least one intermediate host, and a receiving host, and the data transmission characteristics are computed based on single-ended measurements performed at the sending host. | 06-24-2010 |
| 20100157076 | SYSTEMS AND METHODS FOR REDUCING RAIN EFFECTS IN IMAGES - Systems and methods for reducing the visibility of rain in acquired images are provided. One or more inputs relating the scene desired to be acquired by the user are used to retrieve camera settings that will reduce the visibility of rain in acquired images. Additionally, features relating to the scene may be automatically determined and used alone, or in combination with user inputs, to retrieve camera settings. The acquired images may be part of a video. Another feature of the invention is its use as a rain gauge. The camera settings are adjusted to enhance the visibility of rain, then one or more images are acquired and analyzed for the amount and size of raindrops. From this analysis the rain rate can be determined. | 06-24-2010 |
| 20100157030 | SYSTEMS AND METHODS FOR DISPLAYING THREE-DIMENSIONAL IMAGES - Systems and methods for displaying three-dimensional (3D) images are described. In particular, the systems can include a display block made from a transparent material with optical elements three-dimensionally disposed therein. Each optical element becomes luminous when illuminated by a light ray. The systems can also include a computing device configured to generate two-dimensional (2D) images formatted to create 3D images when projected on the display block, by a video projector coupled to the computing device. The video projector is configured to project the 2D images on the block to create the 3D images by causing a set of the passive optical elements to become luminous. Various other systems and methods are described for displaying 3D images. | 06-24-2010 |
| 20100153785 | METHODS, MEDIA, AND SYSTEMS FOR DETECTING AN ANOMALOUS SEQUENCE OF FUNCTION CALLS - Methods, media, and systems for detecting an anomalous sequence of function calls are provided. The methods can include compressing a sequence of function calls made by the execution of a program using a compression model; and determining the presence of an anomalous sequence of function calls in the sequence of function calls based on the extent to which the sequence of function calls is compressed. The methods can further include executing at least one known program; observing at least one sequence of function calls made by the execution of the at least one known program; assigning each type of function call in the at least one sequence of function calls made by the at least one known program a unique identifier; and creating at least part of the compression model by recording at least one sequence of unique identifiers. | 06-17-2010 |
| 20100146569 | SET-TOP BOX PEER-ASSISTED VIDEO-ON-DEMAND - A peer-to-peer (P2P) video-on-demand (VoD) system or method use a plurality of LP-enabled VoD set-top box (STB) peers in a pool for providing video content data to a requesting client peer in the pool. One other peer in the pool can be designated as a parent peer for downloading high priority playback content that is substantially immediately needed for playback display. Low priority pre-fetch content can be downloaded to the requesting client peer from another peer in the pool other than the parent peer. Bandwidth at the requesting client peer that is not used by the playback module for downloading the high priority playback video content data can be allocated for downloading the pre-fetch content. Using the requesting client peer, video content data can be served, for the playback display on a video monitor, wherein such served video data content can comprise the playback content and the prefetch content. | 06-10-2010 |
| 20100136114 | DE NOVO FORMATION AND REGENERATION OF VASCULARIZED TISSUE FROM TISSUE PROGENITOR CELLS AND VASCULAR PROGENTITOR CELLS - It has been discovered that vascularized tissue or organs can be engineered by combined actions of tissue progenitor cells and vascular progenitor cells. Provided herein are compositions and methods directed to engineered vascularized tissue or organs formed by introducing tissue progenitor cells and vascular progenitor into or onto a biocompatible scaffold of matrix material. Also provided are methods of treating tissue defects via grafting of such compositions into subjects in need thereof. | 06-03-2010 |
| 20100135937 | METAL OXIDE NANOCRYSTALS: PREPARATION AND USES - Nanocrystalline forms of metal oxides, including binary metal oxide, perovskite type metal oxides, and complex metal oxides, including doped metal oxides, are provided. Methods of preparation of the nanocrystals are also provided. The nanocrystals, including uncapped and uncoated metal oxide nanocrystals, can be dispersed in a liquid to provide dispersions that are stable and do not precipitate over a period of time ranging from hours to months. Methods of preparation of the dispersions, and methods of use of the dispersions in forming films, are likewise provided. The films can include an organic, inorganic, or mixed organic/inorganic matrix. The films can be substantially free of all organic materials. The films can be used as coatings, or can be used as dielectric layers in a variety of electronics applications, for example as a dielectric material for an ultracapacitor, which can include a mesoporous material. Or the films can be used as a high-K dielectric in organic field-effect transistors. In various embodiments, a layered gate dielectric can include spin-cast (e.g., 8 nm-diameter) high-K BaTiO | 06-03-2010 |
| 20100135252 | METHODS AND SYSTEMS FOR REDUCING MAC LAYER HANDOFF LATENCY IN WIRELESS NETWORKS - In accordance with the present invention, computer implemented methods and systems are provided for reducing handoff latency in a wireless network. In response to detecting that a handoff is necessary, the present invention uses a selective scanning algorithm that includes the use of a channel mask and/or a caching algorithm for detecting one or more new access points. | 06-03-2010 |
| 20100120887 | SUSTAINED RELEASE FORMULATION OF MELATONIN - The present invention relates to low-dose formulations of melatonin, and methods of use thereof, which provide a sustained release of melatonin so as to rapidly increase plasma levels of melatonin, maintain a relatively high level (which mimics the endogenous level of a young subject) for approximately 5-6 hours, and then decrease so as to achieve low levels by early morning (rapid washout), thereby avoiding a “hangover effect”. The sustained release formulations of the invention may be used to treat a variety of sleep-related disorders, including, but not limited to, delayed onset and maintenance forms of insomnia. | 05-13-2010 |
| 20100099580 | Photochemical methods and photoactive compounds for modifying surfaces - Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like. | 04-22-2010 |
| 20100091834 | SYSTEMS AND METHODS FOR TELESCOPIC DATA COMPRESSION IN SENSOR NETWORKS - Systems and methods for telescopic data compression in sensor networks are disclosed herein. An exemplary method of the disclosed subject matter for telescopically compressing data received from a plurality of sensors in a network adapted to detect a field includes broadcasting a first set of sampling positions to sensors, forming a first set of clusters of sensors based on the sampling positions, receiving data from the sensors contained within the clusters, performing local interpolation of the received data, reconstructing a representation of the field using the interpolated data, and determining areas of interest based on the reconstructed representation of the field. | 04-15-2010 |
| 20100081613 | METHODS AND COMPOSITIONS FOR ENHANCING MEMORY - The invention is directed to methods for enhancing memory by administering low doses of beta amyloid peptide. The invention also encompasses methods for increasing synaptic plasticity in a subject which comprises administering to the subject low doses of beta amyloid peptide. | 04-01-2010 |
| 20100076270 | Device for Use in a Surgical Procedure on a Human Eye - Presented is a device for use in a surgical procedure on an eye. The device includes an elongated member that includes a first elongated portion, a second elongated portion, and hook portion. The first elongated portion includes a proximal end and a distal end. The second elongated portion includes a proximal end and a distal end. The proximal end of the second elongated portion is coupled to the distal end of the first elongated portion. The second elongated portion extends from the first elongated portion at an angle to the longitudinal axis of the first elongated portion. The hook portion includes a proximal end and a distal end. The proximal end of the hook portion is coupled to the distal end of the second elongated member. | 03-25-2010 |
| 20100075362 | DEVICE AND METHOD FOR GROWING AND ANALYZING CELLS - A device and method for analyzing cells includes a housing with a chamber, a barrier supported by a frame disposed within the chamber, and a plate arranged at a bottom surface of the housing interior of the chamber. The plate is adapted to receive and sustain cells and the barrier separates the plate into at least two contiguous separate areas. In some embodiments, a thin rubber strip is arranged at the bottom edge of the barrier, which facilitates control of the area in which each cell type is grown, the size of the gap between the cells, and helps prevents over growth of the two cell types on to each other. | 03-25-2010 |
| 20100064368 | Systems, Methods, and Media for Outputting a Dataset Based Upon Anomaly Detection - Systems, methods, and media for outputting a dataset based upon anomaly detection are provided. In some embodiments, methods for outputting a dataset based upon anomaly detection: receive a training dataset having a plurality of n-grams, which plurality includes a first plurality of distinct training n-grams each being a first size; compute a first plurality of appearance frequencies, each for a corresponding one of the first plurality of distinct training n-grams; receive an input dataset including first input n-grams each being the first size; define a first window in the input dataset; identify as being first matching n-grams, the first input n-grams in the first window that correspond to the first plurality of distinct training n-grams; compute a first anomaly detection score for the input dataset using the first matching n-grams and the first plurality of appearance frequencies; and output the input dataset based on the first anomaly detection score. | 03-11-2010 |
| 20100041029 | SYNTHESIS OF FOUR COLOR 3'O-ALLYL, MODIFIED PHOTOCLEAVABLE FLUORESCENT NUCLEOTIDES AND RELATED METHODS - This invention provides a process for making 3′-O-allyl-dGTP-PC-Biodopy-FL-510, 3′-O-allyl-dATP-PC-ROX, 3′-O-allyl-dCTP-PC- and 3′-O-allyl-dUTP-PC-R6G, and related methods. | 02-18-2010 |
| 20100036492 | OSTEOCHONDRAL IMPLANTS, ARTHROPLASTY METHODS, DEVICES, AND SYSTEMS - Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided. | 02-11-2010 |
| 20100034892 | TREATMENT FOR BONE FORMATION DISORDERS BY GROWTH FACTOR DELIVERY - It has been discovered that that certain growth factors can delay the ossification of a tissue site, such as a cranial suture, via the promotion of fibroblast differentiation and/or inhibition of osteoblast differentiation. Provided herein are methods for treating bone formation conditions or disorders, such as synostotic conditions, or ectopic mineralization conditions, via administration of compositions comprising connective tissue growth factor (CTGF), and optionally other growth factors or fibroblast or progenitor cells, to a tissue site of a subject in need thereof. | 02-11-2010 |
| 20100022637 | IDENTIFICATION OF ANTI-CANCER COMPOUNDS AND COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE AND METHODS OF TREATMENT THEREOF - Small molecule screening via high-throughput screening (HTS) methods was employed to identify compounds useful for treating or preventing cancer (such as compounds that enable cells to overcome E6-oncoprotein-mediated drug resistance) or neurodegenerative disorders (such as Huntington's disease, HD). Compounds were identified that potentiate the lethality of anti-tumor agents as well as rescue a disease-state lethality. These compounds are acylated secondary amines referred to herein as indoxins and revertins. | 01-28-2010 |
| 20100019300 | MULTILAYER INTEGRATED CIRCUIT HAVING AN INDUCTOR IN STACKED ARRANGEMENT WITH A DISTRIBUTED CAPACITOR - Some embodiments provide a multilayer integrated circuit, including: a semiconductor substrate including a plurality of channels extending into the substrate from a surface of the substrate; a distributed capacitor including a plurality of gates formed on the surface of the substrate over the channels, and further including an insulator between the gates and the channels, the gates being spaced apart along the surface of the substrate; an interconnect layer formed over the distributed capacitor, the interconnect layer including a plurality of conductors, at least a first conductor being connected to at least some of the gates and at least a second conductor being connected to at least some of the channels; and an inductor formed over the interconnect layer, the inductor including at least conductor arranged on a layer. | 01-28-2010 |
| 20100010804 | METHODS AND SYSTEMS FOR EXTRACTING PHENOTYPIC INFORMATION FROM THE LITERATURE VIA NATURAL LANGUAGE PROCESSING - Systems and methods for extracting and encoding genotype-phenotype information from journal articles and other publications are provided. In some embodiments, the disclosed subject matter includes a preprocessor, boundary identifier, parser, phrase recognizer and an encoder to convert natural-language input text and parameters into structured text. The structured text can take the form of codes which account for genotype-phenotype information and are compatible with a controlled vocabulary. | 01-14-2010 |
| 20100010504 | SYSTEMS, DEVICES, AND METHODS FOR SURGERY ON A HOLLOW ANATOMICALLY SUSPENDED ORGAN - Systems, devices, and methods for surgery on a hollow anatomically suspended organ are described herein. In some embodiments a tele-robotic microsurgical system for eye surgery include: a tele-robotic master and a slave hybrid-robot; wherein the tele-robotic master has at least two master slave interfaces controlled by a medical professional; wherein the slave hybrid-robot has at least two robotic arms attached to a frame releasably attached to a patient's head; wherein the at least two robotic arms each have a parallel robot and a serial robot; and wherein the serial robot includes a tube housing a cannula. | 01-14-2010 |
| 20100004578 | APPARATUS AND SYSTEMS FOR MEMBRANELESS SEPARATION OF FLUIDS - The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of small molecules, middle molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid. | 01-07-2010 |
| 20090325971 | Pentacyclic Alkaloid Compounds and Methods of Use Thereof - The present invention relates to Pentacyclic Alkaloid Compounds, compositions comprising an effective amount of a Pentacyclic Alkaloid Compound and methods for treating or preventing cancer, a bacterial infection, a fungal infection, or a yeast infection, comprising administering to a subject in need thereof an effective amount of a Pentacyclic Alkaloid Compound. The present invention also relates to compounds and methods that are useful for making Cribrostatin IV. | 12-31-2009 |
| 20090325154 | Pyrosequencing Methods and Related Compositions - This invention provides methods for pyrosequencing and compositions comprising 3′-O— modified deoxynucleoside triphosphates. | 12-31-2009 |
| 20090311716 | METHODS TO TREAT OR PREVENT HORMONE-RESISTANT PROSTATE CANCER USING siRNA SPECIFIC FOR PROTOCADHERIN-PC, OR OTHER INHIBITORS OF PROTOCADHERIN-PC EXPRESSION OR ACTIVITY - The invention is directed to compounds and methods for treating or preventing hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity, including antisense oligonucleotides and antibodies. The invention also provides for the use of protocadherin-PC as an in vivo prostate cancer biomarker, and includes a kit for detecting prostate cancer in biological samples. Also covered by the invention is a transgenic non-human mammal engineered to overexpress protocadherin-PC specifically in the prostate. | 12-17-2009 |
| 20090303094 | LOW VOLTAGE DIGITAL TO ANALOG CONVERTER, COMPARATOR AND SIGMA-DELTA MODULATOR CIRCUITS - Circuits that operate with power supplies of less than 1 Volt are presented. More particularly, circuits that operate with supply voltages near or lower than the threshold voltage of the transistors in those circuits are presented. Various circuits embodiments such as operational transconductance amplifiers ( | 12-10-2009 |
| 20090302952 | Systems And Methods For Distributing A Clock Signal - Systems and methods for distributing a clock signal are disclosed. In some embodiments, systems for distributing a clock signal include a plurality of resonant oscillators, each comprising an inductor; and a differential clock grid that distributes the clock signal. The differential clock grid is coupled to the plurality of resonant oscillators and the clock signal, and the inductances of the inductors are configured such that a resonant frequency of the plurality of resonant oscillators is substantially equal to the frequency of the clock signal. | 12-10-2009 |
| 20090298864 | Methods for Treating Mild Cognitive Impairment - The present invention relates to compounds, compositions, and methods useful for: (i) treating or preventing mild cognitive impairment, or (ii) delaying the progression from mild cognitive impairment to Alzheimer's disease in a subject in need thereof. | 12-03-2009 |
| 20090297847 | GROWTH AND APPLICATIONS OF ULTRALONG CARBON NANOTUBES - Ultralong carbon nanotubes can be formed by placing a secondary chamber within a reactor chamber to restrict a flow to provide a laminar flow. Inner shells can be successively extracted from multi-walled carbon nanotubes (MWNTs) such as by applying a lateral force to an elongated tubular sidewall at a location between its two ends. The extracted shells can have varying electrical and mechanical properties that can be used to create useful materials, electrical devices, and mechanical devices. | 12-03-2009 |
| 20090297626 | Methods for preparing metal oxides - The disclosed subject matter provides a method for preparing a metal oxide, the method includes (a) contacting a metal salt precursor with an alcohol to provide a metal oxide; and (b) removing the metal oxide from the alcohol. | 12-03-2009 |
| 20090292119 | METHODS FOR SYNTHESIZING BENZOTHIAZEPINE COMPOUNDS - The present invention provides improved methods for synthesizing novel benzothiazepine compounds. In particular, the invention relates to a new method that generally is used to make the substituted 2,3,4,5-tetrahydro-1,4-benzothiazepine compounds of a general formula | 11-26-2009 |
| 20090280491 | PREDICTING CANCER INVASIVENESS - Provided are methods of determining the likelihood of a human cancer being invasive. Also provided are methods of determining whether a lung adenocarcinoma is a bronchioloalveolar carcinoma (BAC). Additionally provided are methods of deciding a course of treatment for a patient with a cancer. | 11-12-2009 |
| 20090280109 | ILT3 and ILT4-related compositions and methods - This invention provides compositions which comprise at least two of a CD4+CD25+ cell, IL-10, a CD8+CD28− cell and a vitamin D | 11-12-2009 |
| 20090275636 | PICORNAVIRUS AND USES THEREOF - The invention is directed to a a clade of newly isolated and identified picornaviruses associated with respiratory infection, and isolated nucleic acids sequences and peptides thereof. The invention also relates to antibodies against antigens derived from the picornavirus. The invention also relates to iRNAs which target nucleic acid sequences of the picornavirus. The invention is related to methods for detecting the presence or absence of picornavirus in a subject. The invention is also related to immunogenic compositions for inducing an immune response against picornavirus in a subject. | 11-05-2009 |
| 20090274739 | METHODS AND COMPOSITIONS FOR TREATING NEOINTIMAL HYPERPLASIA - The present invention relates to compositions containing an mTOR inhibitor, such as rapamycin or a rapamycin derivative, in combination with a PI3 kinase inhibitor and/or a leptin inhibitor, intraluminal devices configured to release such compositions, and methods for the treatment and/or prevention of intimal hyperplasia, vascular stenosis and/or restenosis comprising delivery of such compositions or intraluminal devices to subjects in need thereof. The compositions, intraluminal devices, and methods of the invention are particularly well-suited for the treatment or prevention of vascular stenosis and restenosis in obese and diabetic subjects. | 11-05-2009 |
| 20090274685 | ILT3 POLYPEPTIDES AND USES THEREOF - This invention provides a method for inhibiting the rejection of transplanted islet cells, comprising administering to the subject a polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water soluble. This invention further provides a method of treating diabetes, by inhibiting the rejection of transplanted islet cells through the administration of the polypeptide to the subject. | 11-05-2009 |
| 20090271182 | COMPUTER-IMPLEMENTED METHODS AND SYSTEMS FOR MODELING AND RECOGNITION OF SPEECH - In accordance with the present invention, computer implemented methods and systems are provided for representing and modeling the temporal structure of audio signals. In response to receiving a signal, a time-to-frequency domain transformation on at least a portion of the received signal to generate a frequency domain representation is performed. The time-to-frequency domain transformation converts the signal from a time domain representation to the frequency domain representation. A frequency domain linear prediction (FDLP) is performed on the frequency domain representation to estimate a temporal envelope of the frequency domain representation. Based on the temporal envelope, one or more speech features are generated. | 10-29-2009 |
| 20090254383 | SYSTEM AND METHOD FOR ALLOCATING RESOURCES USING SPOT MARKET AND DERIVATIVE MARKET TECHNIQUES - A method for controlling access to a system of finite resources with excess demand employs a two stage admission process. Subscribers are first admitted based on an initial bid price and resource availability. The market price is determined by the highest bid price among the rejected arrivals in the current batch. Admitted subscribers are then given the option to secure continued access to the resource by accepting a fee-based reservation. The fee for the reservation is determined in a manner which is fair to the reserving subscriber, as well as all other subscribers, in that the reservation fee is priced to provide access at a cost which prevents arbitraging opportunities. If the current market price exceeds a non-reserved subscriber's bid price, that non-reserved subscriber is displaced. If the current market price exceeds a reserved subscriber's bid price, that reserved subscriber's reservation is activated and access to the resource continues. In the case of a communications system having a finite number of access lines, the reservation fee is based on the bid price from the subscriber and the duration of the requested reservation. | 10-08-2009 |
| 20090221916 | Systems and Methods for Elastography Imaging - Methods for obtaining information about the mechanical behaviour of structures associated with mammalian joints and tendons are provided. Embodiments of such methods include creating deformation in a joint structure (such as ligaments and articular cartilage) or tendon of interest, using an ultrasound scanner and a single element or array of elements to acquire sequences of ultrasound data of the joint structure or tendon, estimating one, two or three components of the resulting displacement and strain between a reference frame of ultrasound data and successive frames of ultrasound data, and using a cross-correlation algorithm to estimate the displacement and strain components. This information may be used to inform the design of tissue grafts. Tissue grafts produced using this information are also provided. The same method can be used in situ together with noninvasive or invasive procedures. | 09-03-2009 |
| 20090214533 | METHODS FOR CONVERTING OR INDUCING PROTECTIVE IMMUNITY - The invention is based in part on the finding that suppressing regulatory T cell function is needed in order to convert passive immunity into active antigen-specific immunity. Generally, the methods of the invention comprise at least the combination of: (1) increasing the amount of immune complexes in the subject, wherein the immune complex comprises a target antigen and a immunoglobulin molecule comprising (i) a variable region specific to the target antigen and (ii) a Fc receptor binding region; and (2) inhibiting regulatory T cell function or decreasing/depleting the regulatory T cell population in the subject. | 08-27-2009 |
| 20090208484 | R-SPONDIN COMPOSITIONS AND METHODS OF USE THEREOF - The invention provides for a method for screening compounds that bind to and modulate a regulator of Wnt signaling, R-spondin 4. The invention further provides for methods for diagnosing a keratin-related abnormality, such as anonychia congenital, in a subject. The invention also provides for isolated RSPO4 mutant molecules. | 08-20-2009 |
| 20090202544 | Methods of Treating Diseases by Targeting Silt3 - This invention provides a method of treating a subject afflicted with a disease, comprising withdrawing blood from the subject, treating the withdrawn blood so as to remove sILT3 from the blood, and returning the treated blood to the subject, thereby treating the subject afflicted with the disease. This invention also provides the above method, further comprising administering an anti-ILT3 antibody to the subject. The invention also provides a method of treating a subject afflicted with a disease, comprising administering to the subject an anti-ILT3 antibody, thereby treating the subject. In one embodiment, the disease is chronic viral disease. In another embodiment, the disease is cancer. | 08-13-2009 |
| 20090202429 | METHODS FOR TESTING ANTI-THROMBOTIC AGENTS - The invention provides a transgenic non-human animal expressing von Willebrand Factor A1 protein containing at least one mutation selected from the group consisting of: 1263P>S, 1269N>D, 1274K>R, 1287M>R, 1302G>D, 1308H>R, 1313R>W, 1314I>V, 1326R>H, 1329L>I, 1330E>G, 1333A>D, 1344T>A, 1347I>V, 1350T>A, 1370G>S, 1379H>R, 1381T>A, 1385T>M 1391P>Q, 1394A>S, 1397L>F, 1421S>N, 1439L>V, 1442G>S, 1449R>Q, 1466A>P, 1469Q>L, 1472Q>H, 1473V>M, 1475H>Q, 1479S>G, and any combination thereof. | 08-13-2009 |
| 20090191657 | ALL-SILICON RAMAN AMPLIFIERS AND LASERS BASED ON MICRO RING RESONATORS - Methods of manufacturing a lasing device are provided by some embodiments, the methods including: creating a silicon micro ring with a predetermined radius and a predetermined first cross-sectional dimension; creating a silicon waveguide with a predetermined second cross-sectional dimension, the silicon waveguide spaced from the silicon micro ring by a predetermined distance; and wherein the predetermined distance, the predetermined radius, the predetermined first cross-sectional dimension, and the predetermined second cross-sectional dimension are determined so that at least one first whispering gallery mode resonant frequency of the silicon micro ring and at least one second whispering gallery mode resonant frequency of the silicon micro ring are separated by an optical phonon frequency of silicon. | 07-30-2009 |
| 20090191244 | MICROBUBBLES AND METHODS FOR OXYGEN DELIVERY - Compositions containing a carrier and microbubles encapsulating one or more gases, preferably oxygen, and methods for making and using the compositions are described herein. The microbubbles contain a lipid envelope formed of at least one base lipid and at least one emulsifying agent. The compositions may be administered to a patient to quickly deliver large amounts of oxygen to the patient's blood supply or directly to a tissue in need of oxygen. The compositions may be administered via injection or as a continuous infusion. The compositions contain a concentrated microbubble suspension, where the suspension contains at least 40 mL oxygen/dL suspension. The microbubbles are preferably less than 20 microns in diameter, more preferably less than 15 microns in diameter. The microbubbles described herein may be administered to a patient in an effective amount to increase in oxygen concentration in the patient's blood, and/or one or more tissues or organs. The microbubbles may be administered alone or in combination with other treatments as an adjuctive therapy. | 07-30-2009 |
| 20090180950 | Polychromatic, diversely-sized particles for angiography - The invention involves polychromatic particles of various sizes for assessing blood flow, blood barrier leakage and blood vessel leakage. | 07-16-2009 |
| 20090175845 | METHODS FOR IDENTIFYING COMPOUNDS THAT MODULATE PHB DOMAIN PROTEIN ACTIVITY AND COMPOSITIONS THEREOF - The invention relates to the finding that PHB domain polypeptides can bind cholesterol and related compounds and are involved in the regulation of various cellular activities. Accordingly, the invention includes methods of identifying compounds that can bind to and/or modulate activity of a PHB domain polypeptide such as Podocin or MEC2. | 07-09-2009 |
| 20090175805 | Neuraminidase Inhibitors and uses thereof - The invention is related to various methods for inhibiting or reducing biofilm formation, treating a biofilm production-related disorder, preventing biofilm formation, and screening for neuraminidase inhibitors. The invention also encompasses a mutant bacterial strain with a deleted neuraminidase gene. | 07-09-2009 |
| 20090157573 | System And Method For Grading Electricity Distribution Network Feeders Susceptible To Impending Failure - A machine learning system creates failure-susceptibility rankings for feeder cables in a utility's electrical distribution system. The machine learning system employs martingale boosting algorithms and Support Vector Machine (SVM) algorithms to generate a feeder failure prediction model, which is trained on static and dynamic feeder attribute data. Feeders are dynamically ranked by failure susceptibility and the rankings displayed to utility operators and engineers so that they can proactively service the distribution system to prevent local power outages. The feeder rankings may be used to redirect power flows and to prioritize repairs. A feedback loop is established to evaluate the responses of the electrical distribution system to field actions taken to optimize preventive maintenance programs. | 06-18-2009 |
| 20090156668 | Ginkgolide Compounds, Compositions, And Extracts, And Uses Thereof - The present invention relates to Ginkgolide derivatives, compositions and extracts comprising one or more Ginkgolides and/or derivatives thereof and methods of use of the compositions to treat neurological disorders and as imaging agents. | 06-18-2009 |
| 20090154823 | Systems and Method for De-Blurring Motion Blurred Images - Systems and methods for providing a substantially de-blurred image of a scene from a motion blurred image of the scene are disclosed. An exemplary system includes a primary detector for sensing the motion blurred image and generating primary image information representing the blurred image, a secondary detector for sensing two or more secondary images of the scene and for generating secondary image information representing the two or more secondary images, and a processor for determining motion information from the secondary image information, estimating a point spread function for the motion blurred image from the motion information, and applying the estimated point spread function to the primary image information to generate information representing the substantially de-blurred image. | 06-18-2009 |
| 20090140801 | Locally gated graphene nanostructures and methods of making and using - A locally gated graphene nanostructure is described, along with methods of making and using the same. A graphene layer can include first and second terminal regions separated by a substantially single layer gated graphene nanoconstriction. A local first gate region can be separated from the graphene nanoconstriction by a first gate dielectric. The local first gate region can be capacitively coupled to gate electrical conduction in the graphene nanoconstriction. A second gate region can be separated from the graphene nanoconstriction by a second gate dielectric. The second gate region can be capacitively coupled to provide a bias to a first location in the graphene nanoconstriction and to a second location outside of the graphene nanoconstriction. Methods of making and using locally gated graphene nanostructures are also described. | 06-04-2009 |
| 20090139931 | SYSTEMS AND METHODS OF MICROFLUIDIC MEMBRANELESS EXCHANGE USING FILTRATION OF EXTRACTION OUTLET STREAMS - A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration. | 06-04-2009 |
| 20090137565 | Method for treatment of movement disorders - The invention is directed to methods of treating movement disorders by administering an effective amount of the compound of formula (I) to patients in need thereof. More particularly, the invention is directed to a method for treating myoclonus including administering to a patient a compound of formula (I), wherein the myoclonus is not alcohol responsive essential myoclonus with dystonia. In some embodiments, the myoclonus is posthypoxic myoclonus. The invention is also directed to a method for treating dystonia, essential tremor cerebellar tremor, a tic, or chorea, including administering to a patient a compound of formula (I). | 05-28-2009 |
| 20090113375 | METHODS, MEDIA, AND MEANS FOR FORMING ASYNCHRONOUS LOGIC NETWORKS - Methods, media, and means for forming asynchronous logic networks are provided. In some embodiments, methods for forming an asynchronous logic network are provided. The methods include: receiving a logic network including vertices and signals, wherein the vertices include vertices with multiple output signals; determining a set of signals of the signals included in the logic network to be covered; selecting at least one vertex in the logic network to cover each signal in the set of signals; replacing the at least one selected vertex with a robust vertex; and replacing at least one non-selected vertex with a relaxed vertex. | 04-30-2009 |
| 20090105092 | VIRAL DATABASE METHODS - Disclosed are methods for designing oligonucleotides that can detect/identify any unknown or known virus of a particular taxon. Also provided are methods to establish, implement and validate bioinformatics tools and databases to support microarray design. The invention also provides specialized arrays for detection and speciation of select viral agents and viruses as well as a set of oligonucleotides that can detect/identify any unknown or known virus of a particular taxon. | 04-23-2009 |
| 20090104645 | Vectors And Methods For Identifying Proteins Amenable To Crystallization - The present invention provides for methods, systems and materials that may be used to identify and select proteins that are amenable to crystallization. While previous methods of screening proteins for crystallization required at least microgram quantities of purified protein, the inventive method can be practiced using nanogram quantities of unpurified protein. | 04-23-2009 |
| 20090103102 | SYSTEMS AND METHODS FOR DIGITAL DETECTION OF A TOMOGRAPHIC SIGNAL - Systems and methods for digital detection of an analog tomographic signal are described. The methods include receiving an amplitude-modulated analog signal containing tomographic information, the analog signal having a modulation frequency, f | 04-23-2009 |
| 20090075335 | SELF-ASSEMBLING PROTEIN HYDROGEL WITH BIO-ACTIVE PROTEIN - Protein hydrogel monomers incorporating bio-active proteins and methods for producing the same are provided. In some embodiments, the disclosed subject matter includes a protein hydrogel monomer including a bio-active protein and two alpha helices that are adapted to interact with alpha helices on other monomers to form coiled-coil junctions. | 03-19-2009 |
| 20090047258 | COMPOSITIONS AND METHODS FOR REVERSING AGE-RELATED CHANGES IN EXTRACELLULAR MATRIX PROTEINS - The invention is directed to compositions and methods for reversing age-related changes in extracellular matrix proteins, particularly the collagen framework of basement membranes of various organs. The invention has particular application to age-related changes that impair Retinal Pigment Epithelium (RPE) cell repopulation of human Bruch's membrane. | 02-19-2009 |
| 20090045181 | SYSTEMS AND METHODS FOR PROCESSING THIN FILMS - The present disclosure is directed to methods and systems for processing a thin film samples. In an exemplary method, semiconductor thin films are loaded onto two different loading fixtures, laser beam pulses generated by a laser source system are split into first laser beam pulses and second laser beam pulses, the thin film loaded on one loading fixture is irradiated with the first laser beam pulses to induce crystallization while the thin film loaded on the other loading fixture is irradiated with the second laser beam pulses. In a preferred embodiment, at least a portion of the thin film that is loaded on the first loading fixture is irradiated while at least a portion of the thin film that is loaded on the second loading fixture is also being irradiated. In an exemplary embodiment, the laser source system includes first and second laser sources and an integrator that combines the laser beam pulses generated by the first and second laser sources to form combined laser beam pulses. In certain exemplary embodiments, the methods and system further utilize additional loading fixtures for processing additional thin film samples. In such methods and systems, the irradiation of thin film samples loaded on some of the loading fixtures can be performed while thin film samples are being loaded onto the remaining loading fixtures. In certain exemplary methods and systems, the crystallization processing of the semiconductor thin film samples can consist of a sequential lateral solidification (SLS) process. | 02-19-2009 |
| 20090027036 | SENSING DEVICES FROM MOLECULAR ELECTRONIC DEVICES UTILIZING HEXABENZOCORONENES - The present invention generally relates to the fabrication of molecular electronics devices from molecular wires and Single Wall Nanotubes (SWNT). In one embodiment, the cutting of a SWNT is achieved by opening a window of small width by lithography patterning of a protective layer on top of the SWNT, followed by applying an oxygen plasma to the exposed SWNT portion. In another embodiment, the gap of a cut SWNT is reconnected by one or more difunctional molecules having appropriate lengths reacting to the functional groups on the cut SWNT ends to form covalent bonds. In another embodiment, the gap of a cut SWNT gap is filled with a self-assembled monolayer from derivatives of novel contorted hexabenzocoranenes. In yet another embodiment, a device based on molecular wire reconnecting a cut SWNT is used as a sensor to detect a biological binding event. | 01-29-2009 |
| 20090019537 | SYSTEMS AND METHODS FOR INHIBITING ATTACKS WITH A NETWORK - Systems and methods for inhibiting attacks with a network are provided. In some embodiments, methods for inhibiting attacks by forwarding packets through a plurality of intermediate nodes when being transmitted from a source node to a destination node are provided, the methods comprising: receiving a packet at one of the plurality of intermediate nodes; determining at the selected intermediate node whether the packet has been sent to the correct one of the plurality of intermediate nodes based on a pseudo random function; and forwarding the packet to the destination node, based on the determining. In some embodiments an intermediate node is selected based on a pseudo random function. In some embodiments, systems and methods for establishing access to a multi-path network are provided. | 01-15-2009 |
| 20090017571 | SENSING DEVICES FROM MOLECULAR ELECTRONIC DEVICES - The present invention generally relates to the fabrication of molecular electronics devices from molecular wires and Single Wall Nanotubes (SWNT). In one embodiment, the cutting of a SWNT is achieved by opening a window of small width by lithography patterning of a protective layer on top of the SWNT, followed by applying an oxygen plasma to the exposed SWNT portion. In another embodiment, the gap of a cut SWNT is reconnected by one or more difunctional molecules having appropriate lengths reacting to the functional groups on the cut SWNT ends to form covalent bonds. In another embodiment, the gap of a cut SWNT gap is filled with a self-assembled monolayer from derivatives of novel contorted hexabenzocoranenes. In yet another embodiment, a device based on molecular wire reconnecting a cut SWNT is used as a sensor to detect a biological binding event. | 01-15-2009 |
| 20090010876 | VISFATIN AND USES THEREOF - The invention is directed to methods for treating, inhibiting or prevent the incidence of vascular disease in a subject or in a non-human animal by administering visfatin. Particularly, the invention provides for methods to prevent phagocyte cell death due to ER-stress by the administration of visfatin. The invention also encompasses methods for identifying a visfatin polypeptide or a visfatin nucleic acid capable of treating a vascular disease as well as pharmaceutical compositions comprising visfatin. | 01-08-2009 |
| 20090004756 | METHODS FOR IDENTIFYING AGENTS THAT TARGET LEAKS IN RYANODINE RECEPTORS - The present invention provides screening methods for identifying agents that enhance binding of a ryanodine receptor and its corresponding FKBP protein, such agents to be used in treating diseases associated with ryanodine receptors. | 01-01-2009 |
| 20090004112 | METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES USING NMDA RECEPTOR GLYCINE SITE ANTAGONISTS - The disclosure provides methods for treating a neurodegenerative disease by administering a NMDA receptor glycine site antagonist. Compounds that can be used in the methods are also provided. Methods are also provided for determining whether a compound inhibits activity of a Parkinson's Disease-associated mutant of leucine-rich repeat kinase-2 (LRRK2). The methods include assessing accumulation of axonal spheroid inclusions, branching and length of neuronal processes, and neuronal cell death. | 01-01-2009 |
| 20080315177 | LIGHT EMISSION USING QUANTUM DOT EMITTERS IN A PHOTONIC CRYSTAL - Devices and methods of manufacturing; for emitting substantially white light using a photonic crystal are described. The photonic crystal has a lattice of air holes and is made from a substrate containing quantum dots. The substrate is etched with three defects that are optically coupled together so that each emits only certain frequencies of light. In combination, the defects can produce substantially white light. The parameters of the photonic crystal are dimensioned so as to cause the coupling between the defects to produce substantially white light. | 12-25-2008 |
| 20080306145 | Preparation Of Ginkgolide And F-Seco-Ginkgolide Lactols - The present invention relates to synthesis of C | 12-11-2008 |
| 20080301101 | SYSTEMS, METHODS, MEANS, AND MEDIA FOR RECORDING, SEARCHING, AND OUTPUTTING DISPLAY INFORMATION - Systems for recording, searching, and outputting display information are provided. In some embodiments, systems for recording display information are provided. The systems include a virtual display that: intercepts display-changes describing changes to be made to a state of a display; sends the display-changes to a client for display; records the display-changes; and a context recorder that records context information describing a state of the display derived from a source independently of the display changes and independently of screen-images. In some embodiments, the systems further include a display system that generates an output screen-image based at least in part on at least one of the display-changes and in response to a search of the context information. In some embodiments, the virtual display further records screen-images; and the display system further generates the output screen-image based at least in part on a recorded-screen-image of the recorded screen-images. | 12-04-2008 |
