| The Trustee of the University of Pennsylvania Patent applications |
| Patent application number | Title | Published |
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| 20100302399 | HIGH LINEAR DYNAMIC RANGE IMAGING - A method for digital processing comprises receiving a first set of image data corresponding to a first time and a second set of image data corresponding to a different time. Intensity values for each of a first pixel and second pixel are extracted from each of the first and second set of image data. Substantially linear values in a plurality of intensity values are identified for each of the first and second pixels. For each of the first and second pixels, regression is performed on each of the substantially linear values in the plurality of intensity values. The regression may calculate an intensity level as a function of exposure time. The regression may generate slopes corresponding to the linear values for each of the first and second pixels. These slopes more accurately represent the actual ratio of intensity values. The ratios are useful in applications, such as, for example, polarization. | 12-02-2010 |
| 20100285608 | CONFORMATIONAL ENTROPY IN MOLECULAR RECOGNITION - The present invention provides methods for the determination of the degree of molecular recognition of a protein with a ligand, including a first protein with a second protein. The methods may comprise determining the squared generalized order parameter (hereinafter, O) for at least one intramolecular bond of the first protein. The protein is then formed into a complex with a ligand. The value or values of O2 for the said at least one bond of the protein is then determined while the protein and the ligand are in the complex. The O value or values determined for the protein while the protein and the ligand are in a complex are compared or related to the O value or values determined for the uncomplexed protein. | 11-11-2010 |
| 20100282258 | METHOD AND APPARATUS FOR PROVIDING PULSES INHALATION OF 17O2 FOR MAGNETIC RESONANCE IMAGING OF CEREBRAL METABOLISM - Prior approaches have delivered O | 11-11-2010 |
| 20100015595 | Phage Particle Diagnostic Reagents - The present invention relates to novel methods for detecting a member of a known binding pair in a sample, including a cell, where one member of the pair (termed the “receptor”) is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the “ligand” or “target”). Rather than detecting the binding of the phage using antibody-based technology, the present invention relates to detecting marker molecule associated with the phage. In one aspect, the invention relates to identifying an antigen-bearing moiety (e.g., a red blood cell antigen) of interest present on a cell, e.g., a red blood cell, using antibody-displaying bacteriophage, as well as detecting anti-red blood cell auto- or alloantibodies and/or complement in a sample, using antiglobulin reagent-displaying bacteriophage and detecting a marker molecule associated with the phage. In one aspect, the phenotype of the phage is not linked with the genotype of the phage. | 01-21-2010 |
