| THE SALK INSTITUTE FOR BIOLOGICAL STUDIES Patent applications |
| Patent application number | Title | Published |
|---|
| 20120134985 | METHODS FOR MODULATING METABOLIC AND CIRCADIAN RHYTHMS - The role of AMPK in arcadian rhythms and methods of screening for agents that modulate such rhythms are disclosed. Compositions that are useful for modulating such rhythms and uses thereof are also disclosed. | 05-31-2012 |
| 20120134928 | MODULATION OF TERMINASE ACTIVITY AT TELOMERES AND DNA DOUBLE-STRAND BREAKS - The present invention is directed to compositions and methods concerning terminase proteins. In particular, the present invention is directed to terminase proteins and their function in processing telomeres and double-strand breaks. | 05-31-2012 |
| 20120122957 | REGULATION OF AGING BY MODULATION OF MITOCHONDRIAL FUNCTION - The invention relates to the field of longevity enhancement. More particularly, the invention provides compositions and methods relating to modulation of mitochondrial function. In certain embodiments, the invention provides methods and related compositions for the enhancement of longevity in an animal, comprising inhibition of one or more electron transport chain components, such as cco-1 and homologs thereof, in a tissue-specific manner in the animal. | 05-17-2012 |
| 20120107286 | PLURIPOTENT STEM CELLS - Methods and compositions for the generation and use of footprint-free human induced pluripotent stem cells are provided. | 05-03-2012 |
| 20120077224 | UNNATURAL AMINO ACID INCORPORATION IN EUKARYOTIC CELLS - This disclosure concerns compositions and methods for improving the incorporation of unnatural amino acids (UAAs) into proteins in eukaryotic cells. It is shown herein that mutation of a prokaryotic tRNA synthetase to increase the interaction with the corresponding tRNA anticodon region results in increased UAA incorporation efficiency in mammalian cells. | 03-29-2012 |
| 20120076762 | INDUCED PLURIPOTENT STEM CELL GENERATION USING TWO FACTORS AND P53 INACTIVATION - Methods and compositions are provided for, inter alia, the generation of induced pluripotent stem cells. Induced pluripotent stem cells may be generated by reprogramming and inhibition of p53. Further, useful intermediates for the generation of induced pluripotent stem cells are also provided. | 03-29-2012 |
| 20120017335 | ZINC KNUCKLE PROTEINS - TZP proteins and method of their use for improving plant characteristics are disclosed. | 01-19-2012 |
| 20120016016 | METHODS AND COMPOSITIONS FOR TREATING COMPLICATIONS OF DIABETES AND VASCULAR DISEASES USING FLAVONES - Disclosed herein, inter alia, are methods and compositions for treating a complication of diabetes or a vascular disease using a 5-desoxy-flavone and/or 5-desoxy-flavonol. | 01-19-2012 |
| 20120003655 | IDENTIFICATION OF NEUROPROTECTIVE AGENTS USING PRO-INFLAMMATORY HUMAN GLIAL CELLS - Provided herein are methods for, inter alia, identifying new therapeutic agents using human cell-based models. | 01-05-2012 |
| 20110306073 | METHOD AND COMPOSITIONS FOR DETERMINING ENZYMATIC ACTIVITY AND SPECIFICITY OF METHYLTRANSFERASES - The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyltransferases, methods of identifying potential substrates of O-methyltransferases, and methods of identifying potential inhibitors of methyltransferases. | 12-15-2011 |
| 20110262347 | METHODS AND COMPOSITIONS FOR ENHANCED DELIVERY OF COMPOUNDS - Disclosed are compositions and methods related to multivalent compositions targeted to cells and tissues. The disclosed targeting is useful for treatment of cancer and other diseases and disorders. | 10-27-2011 |
| 20110223667 | METABOLIC ENGINEERING OF LIPID METABOLISM BY IMPROVING FATTY ACID BINDING AND TRANSPORT - CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided. | 09-15-2011 |
| 20100303775 | Generation of Genetically Corrected Disease-free Induced Pluripotent Stem Cells - Methods and compositions for the generation and use of genetically corrected induced pluripotent stem cells are provided. | 12-02-2010 |
| 20100266604 | USE OF TAM RECEPTOR INHIBITORS AS IMMUNOENHANCERS AND TAM ACTIVATORS AS IMMUNOSUPPRESSORS - This disclosure concerns compositions and methods for immunoenhancement and/or immunosuppression. In certain embodiments, the disclosure concerns methods of using a TAM receptor inhibitor for immunoenhancement, for example as a vaccine adjuvant, for the treatment of sepsis, or for treating an immunocompromised subject. Also disclosed are methods of screening for immunoenhancing agents. In other embodiments, the disclosure concerns methods of using a TAM receptor agonist for immunosuppression, for example as a treatment for an autoimmune disorder, for the treatment of an allergy, or for treating graft-versus-host disease in a subject. Also disclosed are methods of screening for immunosuppressive agents. | 10-21-2010 |
| 20100263062 | METHODS FOR SCREENING AND COMPOUNDS THAT PROTECT AGAINST AMYLOID DISEASES - The disclosure provides methods and compositions useful for screening inhibitors of aggregation mediated proteotoxicity. The disclosure provides transgenic animals and cell useful for such screening. Also provided are compounds useful for inhibiting aggregation mediated proteotoxicity in a subject. | 10-14-2010 |
| 20100248265 | COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF CANCER - Provided herein are methods and compositions useful in the diagnosis and treatment of cancer. The methods and compositions typically involve detecting a level of phosphorylation of mTOR at serine 2481 in a subject and comparing the level of phosphorylation of mTOR at serine 2481 in said subject with a standard control. | 09-30-2010 |
| 20100242135 | ETP1 AND ETP2 REGULATE PLANT ETHYLENE RESPONSE - ETP1 and ETP2 bind to EIN2 and modulate plant ethylene sensitivity. | 09-23-2010 |
| 20100221777 | DESIGNER LIGANDS OF TGF-BETA SUPERFAMILY - The present disclosure relates to chimeric polypeptide having TGF-beta activity, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides. | 09-02-2010 |
| 20100166710 | Compositions and Methods for Inducing Neuronal Differentiation - The present invention provides compositions and methods for inducing neuronal cell differentiation. | 07-01-2010 |
| 20100144543 | Epigenetic silencing of tumor suppressor genes - Provided are methods of identifying a compound that binds to or modulates an activity of a CTCF polypeptide or CTCF polypeptide complex. Also provided are methods of monitoring a cancer state of a cell by detecting a chromatin boundary proximal to a tumor suppressor gene of the cell and by monitoring the formation of a gene-specific CTCF polypeptide complex in the cell. In addition, methods of selecting a treatment or determining a prognosis for a cancer related disease are provided. Provided are recombinant cells comprising recombinant CTCF genes, recombinant cells comprising CTCF knock downs or knock outs, and recombinant laboratory animals comprising CTCF knock downs or knock outs. | 06-10-2010 |
| 20100061981 | p75NTR MEDIATES EPHRIN-A REVERSE SIGNALING - The disclosure comprises methods and compositions for stimulating axon outgrowth and inhibiting metastatic diseases and disorders. | 03-11-2010 |
| 20090209500 | USE OF VITAMIN D RECEPTOR AGONISTS AND PRECURSORS TO TREAT FIBROSIS - This application relates to methods of treating, preventing, and ameliorating fibrosis, such as fibrosis of the liver, kidney, or pancreas. In particular, the application relates to methods of using a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin D receptor agonists precursors) for the treatment of fibrosis. Also disclosed are methods for screening for agents that treat, prevent, and ameliorate fibrosis. | 08-20-2009 |
| 20090192720 | METHODS AND COMPOSITIONS FOR DETERMINING ENZYMATIC ACTIVITY AND SPECIFICITY OF METHYLTRANSFERASES - The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyl-transferases, methods of identifying potential substrates of O-methyltransferases, and methods of identifying potential inhibitors of methyltransferases. | 07-30-2009 |
| 20090158468 | Metabolic engineering of lipid metabolism by improving fatty acid binding and transport - CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided. | 06-18-2009 |
| 20090149629 | CRFR1 SELECTIVE LIGANDS - CRF peptide analogs that bind to CRFR1 with an affinity far greater than they bind to CRFR2. Some of these analogs exhibit CRF agonist activity. One exemplary analog that may be made by solid-phase synthesis is: | 06-11-2009 |
| 20090013433 | Compositions, cells, and plants that include BKI1, a negative regulator of BRI1-mediated BR signaling - This invention provides recombinant cells and transgenic plants that display selectively increased or decreased response to brassinosteroids, resulting in increased yield. Methods of modulating brassinosteroid responses, and of modulating plant phenotypes, are provided. | 01-08-2009 |
| 20080299148 | Novel antitoxin and vaccine platform based on nodavirus VLPS - Antitoxin and vaccine compositions based on nodavirus VLPs are provided. Anthrax antitoxin and vaccine compositions are provided. Methods of treating toxins with VLP-based antitoxins are provided. Methods of raising an immune response with immunogen decorated VLPs are provided. | 12-04-2008 |
| 20080292591 | Tumor mouse models using lentiviral vectors - This invention provides model systems for study of tumors. Model cells and model animals are prepared to mimic characteristics of natural clinical tumors. The tumor models can be contacted with putative modulators to screen for therapeutics and to help understand tumorigenic processes. Model animals can include model cells, closely correlated to the characteristics of clinical tumors, in an environment closely mimicking that of the tumors in patients. Thus, the animal models are highly representative for use in clinical and pharmacological studies. | 11-27-2008 |
| 20080260638 | RECEPTOR(SSTR2)-SELECTIVE SOMATOSTATIN ANTAGONISTS - SRIF peptide antagonists, which are selective for SSTR2 in contrast to the other cloned SRIF receptors and which bind with high affinity to the cloned human receptor SSTR2 but do not activate the receptor, have many useful functions. Because they do not bind with significant affinity to SSTR1, SSTR3, SSTR4 or SSTR5, their administration avoids potential undesirable side effects. Because they block the receptor function, they can be used therapeutically to block certain physiological effects which SSTR2 mediates. By incorporating radioiodine or the like in these SSTR2-selective SRIF antagonists, a labeled compound useful in drug-screening methods is provided. Alternatively, for use in therapy, highly radioactive moieties can be N-terminally coupled, complexed or chelated thereto. | 10-23-2008 |
| 20080214470 | Pin1-Modulating Compounds and Methods of Use Thereof - The invention is directed to peptide modulators of Pin1 and Pin1-related proteins and the use of such modulators for treatment of Pin1 associated states, e.g., for the treatment of cancer or neurodegenerative disease. | 09-04-2008 |
