| The Research Foundation of State University of New York Patent applications |
| Patent application number | Title | Published |
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| 20120127426 | METHOD AND SYSTEM FOR TREATING BINOCULAR ANOMALIES - A system for treating binocular anomalies. The system includes one or more imaging devices, one or more visual displays, and a computing device. The imaging devices may include right and left imaging devices that capture images of a patient's right and left eyes, respectively. The displays may include right and left displays that provide right and left visual stimulation, respectively. The computing device identifies right and left locations on the right and left retinas, respectively, based at least in part on images of right and left eyes, respectively. The brain fuses images positioned at the right and left locations on the retinas into a single image. The computing device transmits right and left positioning signals to the right and left displays, respectively, that indicate that the right and left visual stimulation, respectively, are to be displayed so they are positioned at the right and left locations, respectively, on the retinas. | 05-24-2012 |
| 20120110707 | Metrology Probe and Method of Configuring a Metrology Probe - A metrology probe capable of measurements of a broad range of physical properties of individual samples of nano- or sub-nanometer dimensions is provided. The probe comprises a probe body, a substrate connected to the probe body, and a tip proximate the substrate. The probe further comprises a coarse piezoelectric actuator having an electrical input. The coarse piezo is configured to cause the tip and/or the substrate to move relative to each other when a first electrical signal is provided to the electrical input. The probe further comprises a low-pass filter in electrical communication with the electrical input of the coarse piezo. The probe further comprises a fine piezoelectric actuator having an electrical input configured to cause the tip and/or the substrate to move relative to each other when a second electrical signal is provided to the electrical input. | 05-03-2012 |
| 20120101255 | PEPTIDE-BASED REGULATION OF GAP JUNCTIONS - The present invention relates to proteins and polypeptides as well as methods of using these proteins and polypeptides to: identify the location of an RXP-binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT. | 04-26-2012 |
| 20120097848 | SCANNING INCREMENTAL FOCUS MICROSCOPY - Method and apparatus are provided for generating an enhanced image of an object. The method includes obtaining images of an area of an object generated using a probe of having a probe size greater than or equal to a minimum probe area size. An enhanced image of the area of the object is generated by accurately computing the emission intensities emitted from pixel areas smaller than the minimum probe size and within the area of the object. This is repeated for other areas of the object to form other enhanced images. The enhanced images are combined to form an accurate enhanced image of the object. | 04-26-2012 |
| 20120097209 | FABRICATION OF SURFACE TEXTURES BY ION IMPLANTATION FOR ANTIREFLECTION OF SILICON CRYSTALS - The invention relates to a new method of texturing silicon surfaces suited for antireflection based on ion implantation of hydrogen and heavy ions or heavy elements combined with thermal annealing or thermal annealing and oxidation. The addition of the heavy ions or heavy elements allows for a more effective anti-reflective surface than is found when only hydrogen implantation is utilized. The methods used are also time- and cost-effective, as they can utilize already existing semiconductor ion implantation fabrication equipment and reduce the number of necessary steps. The antireflective surfaces are useful for silicon-based solar cells. | 04-26-2012 |
| 20120088818 | CONFORMATION-SELECTIVE NUCLEIC ACID INHIBITORS OF AMPA GLUTAMATE RECEPTORS - The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. | 04-12-2012 |
| 20120088656 | NANOSTRUCTURES HAVING ENHANCED CATALYTIC PERFORMANCE AND METHOD FOR PREPARING SAME - Provided herein is a nanostructure refined by suspending an unrefined nanostructure with a solvent, dispersing the suspended nanostructure in an acidic solution and agitating the acidic solution to produce a refined nanostructure. | 04-12-2012 |
| 20120082676 | METHODS FOR PREVENTING AND TREATING ANGIOEDEMA - One aspect of the present invention provides a method of treating or preventing angioedema in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R. One aspect of the present invention provides a method of treating or preventing vascular permeability in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R. | 04-05-2012 |
| 20120064113 | Novel Attenuated Poliovirus - A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2a | 03-15-2012 |
| 20120061329 | APPARATUS AND METHOD FOR ULTRASOUND TREATMENT FOR BALLAST WATER MANAGEMENT - The invention provides a method of treating a target area with an ultrasound wave pattern, including: providing an ultrasound apparatus having an ultrasound wave generator operatively attached to a plurality of transducers, coupled to an immersible support and configured to emit an ultrasound wave; immersing the apparatus into a water environment; positioning the apparatus proximate to a target area to treat at least one in situ organism; and emitting a pattern of ultrasound waves from the transducers, the pattern of ultrasound waves additive in effect and emitted onto the target area to threat an in situ underwater organism. | 03-15-2012 |
| 20120059228 | METHODS FOR DETECTING ENDOMETRIOSIS - The method of the present invention is directed towards detecting endometriosis in a mammalian subject. This method comprises the following steps; taking a sample from the mammal, measuring the level of sphingomyelin (SM) or phosphatidylcholine (PC), or combinations thereof, in the sample, comparing the measured levels of SM or PC, or combinations thereof, to predetermined levels, and diagnosing the mammal based on the comparison. This method may also comprise the following steps: taking a sample from the mammal, measuring the level of F11 Receptor (F11R) in the sample, comparing the measured level of F11R to a predetermined level, and diagnosing the mammal based on the comparison. | 03-08-2012 |
| 20120046249 | METHODS OF REDUCING THE RISK OF CARDIOVASCULAR DISEASE IN POSTMENOPAUSAL WOMEN - The present invention features materials and methods for reducing the risk of cardiovascular disease in postmenopausal or perimenopausal women. More specifically, these methods can be used in women who generally have no apparent cardiovascular disease. We describe herein methods of administering non-antibacterial tetracycline or a sub-antimicrobial amount of antibacterial tetracyclines or tetracycline formulations and their use in reducing the risk that cardiovascular disease will develop in a subject (e.g., in a post- or perimenopausal woman) | 02-23-2012 |
| 20120034661 | STRAINS FOR THE PRODUCTION OF FLAVONOIDS FROM GLUCOSE - The invention relates to the production of flavonoids and flavonoid precursors in cells through recombinant expression of tyrosine ammonia lyase (TAL), 4-coumarate:CoA ligase (4CL), chalcone synthase (CHS), and chalcone isomerase (CHI). | 02-09-2012 |
| 20120029028 | Compositions and methods for treating hyperlipidemias - The present invention is directed to a composition and method for the treatment of hyperlipidemias by targeting Microsomal triglyceride transfer protein (MTP). In particular, the present invention is directed to a combination of at least one MTP inhibitor and at least one lipid-lowering agent, both in an amount effective to treat hyperlipidemias. | 02-02-2012 |
| 20120028241 | Assay System for Monitoring the Effects of Genetically Engineered Cells to Alter Function of a Synctium - This invention provides methods for determining the ability of a gene construct to alter the rhythm and contractility of a syncytial cell. Furthermore, this invention provides methods for constructing a gene construct capable of altering the rhythm or contractility of a syncytial cell. Finally, this invention provides a method for constructing a gene construct capable of coupling to a syncytial cell. | 02-02-2012 |
| 20120027828 | Dental anti-hypersensitivity composition and method - The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion. | 02-02-2012 |
| 20120004175 | INHIBITORS OF NF-KB ACTIVITY - The present invention provides a method for inhibiting NF-κB activity in a subject, the method comprising providing an agent capable of inducing expression of annexin 1, whereby said agent induces expression of annexin 1 and whereby said induced expression of annexin 1 inhibits NF-κB activity. Also provided are annexin 1 mimetics capable of binding to NF-κB and pharmaceutical compositions of such inducing and mimetic agents. | 01-05-2012 |
| 20120003119 | ANTIMICROBIAL PEPTIDES - The present invention is directed to a method for disinfecting or sterilizing food, particularly, fresh produce, fruits and vegetables, by applying antimicrobial polypeptides (AMP). The AMP used in the present invention consists of from 13 to 20 amino acids and has an amphipathic alpha helix structure, wherein 3 or more of the amino acids form a positively charged domain extending axially along the alpha helix. | 01-05-2012 |
| 20110312016 | Method for Evaluating Immunosuppression - Provided is a method for determining immunosuppression in an individual. The method entails obtaining a sample of blood from an individual, contacting cells in the blood sample with an activating agent to obtain activated cells, measuring the amount of nuclear NFkB in the activated cells, and comparing the amount of nuclear NFkB in the activated cells to a control. An amount of nuclear NFkB that is higher than the control is considered to be indicative of insufficient immunosuppression in the individual. An amount of nuclear NFkB that is lower than the control is considered to he indicative of excessive immunosuppression in the individual. An amount of nuclear NFkB that is the same as the control is considered to be indicative of an appropriate amount of immunosuppression in the individual. | 12-22-2011 |
| 20110308428 | CEMENT-SETTING-TIME ACCELERATOR COMPOSITIONS - Setting time accelerator compositions for Portland type cements include two of the following compounds: a) CaCl2, b) Phosphate, c) Silica, that may be used in a dental coating. | 12-22-2011 |
| 20110294740 | TREATMENT OF AMYLOIDOSES USING MYELIN BASIC PROTEIN AND FRAGMENTS THEREOF - In its various embodiments, the invention provides myelin basic proteins and fragments of that interfere with the fibril lization of peptides implicated in the amyloidoses, especially the amyloid-beta peptide associated with Alzheimer's disease (“AD”) and cerebral amyloid angiopathy (“CAA”). Some embodiments provide methods of identifying additional interfering fragments. Others provide methods of identifying substances that modulate the interference. Further embodiments provide methods of preventing amyloidoses, especially AD and CAA by administering myelin basic proteins or fragments thereof. | 12-01-2011 |
| 20110286610 | SURFACE MICROMACHINED DIFFERENTIAL MICROPHONE - A differential microphone having a perimeter slit formed around the microphone diaphragm that replaces the backside hole previously required in conventional silicon, micromachined microphones. The differential microphone is formed using silicon fabrication techniques applied only to a single, front face of a silicon wafer. The backside holes of prior art microphones typically require that a secondary machining operation be performed on the rear surface of the silicon wafer during fabrication. This secondary operation adds complexity and cost to the micromachined microphones so fabricated. Comb fingers forming a portion of a capacitive arrangement may be fabricated as part of the differential microphone diaphragm. | 11-24-2011 |
| 20110275156 | Delivery of DNA or RNA Via Gap Junctions from Host Cells to Target Cells and a Cell-Based Delivery System for Antisense or siRNA - A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell. | 11-10-2011 |
| 20110256112 | Compensating for Atrioventricular Block Using a Nucleic Acid Encoding a Sodium Channel or Gap Junction Protein - A method of increasing the velocity of AV conduction in a mammal that may be in heart block or at risk of heart block by causing, in an AV node and/or His bundle having less than normal conduction speed, the expression of a sodium channel or gap junction protein, such as the SkM-1 channel, Cx43 or Cx32, so as to increase the velocity of conduction by the AV node. | 10-20-2011 |
| 20110224143 | NUCLEOBINDIN I VARIANT PROTEIN COMPOSITIONS AND METHODS OF USE - The invention relates to Nucleobindin-1 (NUCB1) protein variants that are capable of disaggregating amyloid fibrils as well as inhibiting the formation of fibrils in the presence of physiological concentrations of calcium. Isolated NUCB1 protein variants, nucleic acids encoding the protein variants, cells comprising the isolated nucleic acids, pharmaceutical compositions and kits comprising the variants, methods of making the variants, and therapeutic uses of the variants are provided. | 09-15-2011 |
| 20110223144 | Creation of a Biological Atrioventricular Bypass to Compensate for Atrioventricular Block - A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle. | 09-15-2011 |
| 20110223102 | MULTIMODALITY AGENTS FOR TUMOR IMAGING AND THERAPY - A compound that is a conjugate of an antagonist to an integrin expressed by a tumor cell and at least one of a tumor avid tetrapyrollic photosensitizer, a fluorescent dye, and a radioisotope labeled moiety wherein the radioisotope is | 09-15-2011 |
| 20110212136 | Nanosphere/Microsphere Delivery System for the Treatment of Spinal Cord Injury - A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic spinal chord injury in a mammal having the same is provided. The biodegradable nanosphere/microsphere formulation releases cABC or a functional derivative of cABC in a time-released manner at the site of the spinal cord injury. cABC infusion can promote axon regrowth and some behavioral recovery. The nanospheres and/or microspheres provided herein include cABC or a functional derivative of cABC loaded within and/or on a biodegradable polymer matrix. In some embodiments of the present invention, the surface of the biodegradable polymer matrix can be modified to target a specific scar site. In addition to providing a nanosphere formulation that include polymeric incorporated cABC, a method of treating a mammal having a spinal cord injury is also provided. | 09-01-2011 |
| 20110212046 | ALTERNATING RING-OPENING METATHESIS POLYMERIZATION - The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers. | 09-01-2011 |
| 20110201669 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CANCER - The present invention relates to the diagnosis and treatment of cancer, and in particular breast cancer. Specifically, in some embodiments the invention relates to methods of diagnosing cancer, and in particular breast cancer, using an antibody specific for a gene product that localizes selectively to the endoplasmic reticulum of the cancer cell(s). In some embodiments, the invention relates to methods of treating cancer, and in particular breast cancer, by administering a composition comprising an RNA interference sequence (e.g., shRNA, RNAi and/or siRNA molecule) characterized by an ability to inhibit an mRNA molecule, which mRNA molecule is encoded by the C43 gene (SEQ ID NO: 1). The invention additionally relates to methods for detecting cancer cells by detecting reduced methylation of the C43 promoter, and methods for reducing cancer metastasis by using demethylation inhibitors that result in increased methylation of the C43 promoter. The invention additionally relates to an in vitro 3-dimensional assay for detecting migrating cells, identifying test agents and/or nucleotide sequences that alter cell migration. | 08-18-2011 |
| 20110198282 | HIGH FLUX HIGH EFFICIENCY NANOFIBER MEMBRANES AND METHODS OF PRODUCTION THEREOF - A membrane is provided including a coating layer having cellulose nanofibers produced from oxidized cellulose microfibers and an electrospun substrate upon which the coating layer is applied. The nanofibers of the electrospun substrate have a diameter greater than that of the cellulose nanofibers. The membrane also has non-woven support upon which the electrospun substrate is disposed. Microfibers of the non-woven support have a diameter greater than that of the nanofibers of the electrospun substrate. Application of electrospun membrane is in microfiltration area, while the cellulose nanofiber membrane serves in ultra-filtration, nanofiltration, and reverse osmosis after chemical modification. | 08-18-2011 |
| 20110197056 | SECURE DISTRIBUTED STORAGE SYSTEM AND METHOD - Moving from server-attached storage to distributed storage brings new vulnerabilities in creating a secure data storage and access facility. The Data Division and Out-of-order keystream Generation technique provides a cryptographic method to protect data in the distributed storage environments. In the technique, the Treating the data as a binary bit stream, our self-encryption (SE) scheme generates a keystream by randomly extracting bits from the stream. The length of the keystream depends on the user's security requirements. The bit stream is encrypted and the ciphertext is stored on the mobile device, whereas the keystream is stored separately. This makes it computationally not feasible to recover the original data stream from the ciphertext alone. | 08-11-2011 |
| 20110196174 | GREEN SYNTHESIS OF ARYL ALDIMINES USING ETHYL LACTATE - The present invention relates to a method for preparing aryl aldimines. In particular, the present invention relates to methods of preparing aryl aldimines that uses environmentally friendly solvent systems. | 08-11-2011 |
| 20110187707 | SYSTEM AND METHOD FOR VIRTUALLY AUGMENTED ENDOSCOPY - Virtually augmented endoscopy includes overlaying optical endoscopy image data with a virtual endoscopy model. Image distortion in the optical endoscopy image data can be substantially reduced. Features in the virtual endoscopy model can be correlated with features in the optical endoscopy image data to improve examination performance. A correlation path through the virtual endoscopy model can be determined that reasonably follows the physical path of an endoscope. A 2D or 3D correlation model can be generated from the image data and correlated to the virtual endoscopy model. Correlation between the scan data domain and the image data domain can use either the correlation path, correlation model or a combination thereof. CAD tools and other features of virtual endoscopy can then be applied to enhance the performance of optical endoscopy. | 08-04-2011 |
| 20110171292 | PEPTIDE COMPOSITIONS AND METHODS OF USE - The present invention provides isolated peptides with at least two cysteine residues capable of forming one or more disulfide bonds. Pharmaceutical compositions comprising the isolated peptides of the present invention are also provided. The invention also provides methods for inhibiting, preventing or improving the pathological or clinical manifestations of cancer or an inflammatory disease or disorder in a subject, comprising administering a peptide of the invention. | 07-14-2011 |
| 20110160160 | METHODS FOR HEAT SHOCK PROTEIN DEPENDENT CANCER TREATMENT - The present invention provides a method of treating an Hsp70 dependent cancer, including: providing at least one Hsp70 dependent cancer cell; contacting the at least one cell with a sub-effective concentration of a dihydropyrimidinone compound; and contacting the at least one cell with a sub-effective concentration of a proteasome inhibitor, wherein the sub-effective concentration of the dihydropyrimidinone compound and the sub-effective concentration of the proteasome inhibitor have a synergistic effect upon the at least one cell. | 06-30-2011 |
| 20110152570 | METHODS FOR MAKING STERICALLY HINDERED ETHERS - The present invention relates to processes for the production of sterically hindered diol ethers and diacyl ethers of formula | 06-23-2011 |
| 20110152496 | ACID-LABILE POLYMERS AND MONOMERS FOR THEIR CONSTRUCTION - Polymers for photoresists and monomers for incorporation into those polymers are disclosed. The polymers comprise at least two components: an acid labile component and a photolytically stable and acid-stable component. The polymers may also contain a third, photoacid generator (PAG) component. | 06-23-2011 |
| 20110150260 | MINIATURE NON-DIRECTIONAL MICROPHONE - A miniature microphone comprising a diaphragm compliantly suspended over an enclosed air volume having a vent port is provided, wherein an effective stiffness of the diaphragm with respect to displacement by acoustic vibrations is controlled principally by the enclosed air volume and the port. The microphone may be formed using silicon microfabrication techniques and has sensitivity to sound pressure substantially unrelated to the size of the diaphragm over a broad range of realistic sizes. The diaphragm is rotatively suspend for movement through an arc in response to acoustic vibrations, for example by beams or tabs, and has a surrounding perimeter slit separating the diaphragm from its support structure. The air volume behind the diaphragm provides a restoring spring force for the diaphragm. The microphone's sensitivity is related to the air volume, perimeter slit, and stiffness of the diaphragm and its mechanical supports, and not the area of the diaphragm. | 06-23-2011 |
| 20110142949 | CHONDROITINASE TREATMENT METHOD FOR DEMYELINATION-RELATED CONDITIONS AND DISEASES - A method of treating a mammal suffering from a demyelinating disease or condition, the method comprising administering chondroitinase to said mammal at a site where demyelination has occurred. | 06-16-2011 |
| 20110124500 | CATALYTIC PLATINUM-COPPER ALLOY NANOPARTICLES - High-quality bimetallic Pt | 05-26-2011 |
| 20110124499 | CATALYTIC PLATINUM AND ITS 3d-TRANSITION-METAL ALLOY NANOPARTICLES - Platinum (Pt)-based alloys are effective catalysts for oxygen reduction reaction (ORR) or fuel oxidation in proton exchange membrane fuel cells (PEMFCs). A wet-chemical approach for preparing monodisperse Pt | 05-26-2011 |
| 20110116046 | LED VARIABLE LIGHT SOURCE - An LED variable light source of this invention includes a super luminescent LED for generating a continuous light signal having a logarithmically controllable light intensity maintainable over a broad spectral range. The LED variable light source also includes a light lens for receiving and focusing the generated continuous light signal and a controller for controlling the light signal's intensity and frequency range via a driver interface, constructed and arranged to allow a user to input LED variable light source control inputs. | 05-19-2011 |
| 20110111361 | Device For The Detection Of Non-Cavitated Early Dental Caries Lesions - The invention provides a device for detecting non-cavitated caries lesions, including a measuring electrode having an electrically conductive tip. The tip is dimensionally configured to fit within a fissure and provide electrical contact with a patient's tooth. A reference electrode is also included, the reference electrode being configured for electrical contact with the patient's body. A measuring means is also provided for determining electrical conductance between the measuring electrode and the reference electrode, wherein the device is further configured to receive a current source for providing electrical current between the measuring electrode and the reference electrode. | 05-12-2011 |
| 20110100423 | Light Scattering and Transport for Photosensitive Devices - Apparatus and methods are described for efficiently transporting and using incident radiation falling on photosensitive devices and structures supporting photosensitive devices. For example, an apparatus includes a low-absorption medium capable of passing and absorbing incident radiation; a scattering material disposed over at least a portion of or within the low-absorption material, the scattering material permitting a portion of incident light to pass therethrough; and a reflective surface disposed adjacent to the low-absorption medium to reflect radiation towards or within the medium. | 05-05-2011 |
| 20110094692 | METHODS OF PRETREATING COMMINUTED CELLULOSIC MATERIAL WITH CARBONATE-CONTAINING SOLUTIONS - Methods of pretreating comminuted cellulosic material with an acidic solution and then a carbonate-containing solution to produce a pretreated cellulosic material are provided. The pretreated material may then be further treated in a pulping process, for example, a soda-anthraquinone pulping process, to produce a cellulose pulp. The pretreatment solutions may be extracted from the pretreated cellulose material and selectively re-used, for example, with acid or alkali addition, for the pretreatment solutions. The resulting cellulose pulp is characterized by having reduced lignin content and increased yield compared to prior art treatment processes. | 04-28-2011 |
| 20110091373 | PAA NANOPARTICLES FOR ENHANCEMENT OF TUMOR IMAGING - A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same. | 04-21-2011 |
| 20110073264 | Kraft-Pulping of Hot Water Extracted Woodchips - The method of the present invention is directed towards a method to increase the pulp yield of a lignocellulosic material, or increasing pulp bulk and/or pulp viscosity. This method comprises the following steps; preparing a lignocellulosic material, contacting the lignocellulosic material in a vessel with hot water or steam for a predetermined time, producing acetic acid from the reaction of the hot water or steam and the lignocellulosic material, lowering the pH to less than about 4, removing lignocellulosic material extracts including a large percentage of hemicellulose, acetic acid and metal ions, exposing contacted lignocellulosic material to pulping chemicals in a pulping reactor, forming a contacted lignocellulosic material pulp with a kappa number below about 19 after about 90 minutes of contact with the pulping chemicals, exposing the contacted lignocellulosic material pulp to whitening agents, and producing a whitened hot water contacted lignocellulosic material pulp. | 03-31-2011 |
| 20110070206 | METHODS OF APPLYING PHYSICAL STIMULI TO CELLS - We describe herein methods for applying physical stimuli to cells, including mesenchymal stem cells, in culture or in vivo. These methods can be applied in, and are expected to benefit subjects in, a great variety of circumstances that arise in the context of, for example, traumatic injury (including that induced by surgical procedures), wound healing (of the skin and other tissues), cancer therapies (e.g., chemotherapy or radiation therapy), tissue transplantation (e.g., bone marrow transplantation), and aging. More generally, the present methods apply where patients would benefit from an increase in the number of cells (e.g., stem cells) within a given tissue and, ex vivo, where it is desirable to increase the proliferation of cells (e.g., stem cells) for scientific study, inclusion in devices bearing cells (e.g., polymer or hydrogel-based implants), and administration to patients. | 03-24-2011 |
| 20110061446 | SELECTIVE NANOPROBE FOR OLFACTORY MEDICINE - An apparatus is for detecting the presence of selected gaseous compounds indicative of a medical condition includes a probe having one or more sensor elements having a conductivity which is responsive to the presence of selected gaseous compounds, at least one sensor element containing a transition metal oxide selected from the group consisting of WO | 03-17-2011 |
| 20110059556 | Rapid and Continuous Analyte Processing in Droplet Microfluidic Devices - The compositions and methods described herein are designed to introduce functionalized microparticles into droplets that can be manipulated in microfluidic devices by fields, including electric (dielectrophoretic) or magnetic fields, and extracted by splitting a droplet to separate the portion of the droplet that contains the majority of the microparticles from the part that is largely devoid of the microparticles. Within the device, channels are variously configured at Y- or T junctions that facilitate continuous, serial isolation and dilution of analytes in solution. The devices can be limited in the sense that they can be designed to output purified analytes that are then further analyzed in separate machines or they can include additional channels through which purified analytes can be further processed and analyzed. | 03-10-2011 |
| 20110041857 | FIBROBLAST DERIVED STEM CELLS - The present invention provides methods and compositions relating to the production of stem cells, derived from dedifferentiated fibroblasts, and the use of such stem cells for treatment of a variety of different disorders and conditions. The invention is based on the surprising discovery that a population of stem cells, capable of differentiating into a variety of different cell types, can be generated by culturing fibroblasts under selective culture conditions. | 02-24-2011 |
| 20110033647 | NOVEL IONIC LIQUIDS, FUNCTIONALIZED PARTICULATES, AND FLUOROPOLYMER COMPOSITES - The present invention relates to (i) novel fluoroionic compounds capable of dispersing particulate filler compositions into a fluoropolymer; (ii) novel particulate compositions in which particulates are surface-functionalized with a fluoroionic compound; (iii) fluoropolymer composite materials containing the surface-functionalized particulates of (ii) incorporated into a fluoropolymer; (iv) crosslinked versions of (iii); v) methods for producing the crosslinked material of (iv); and (vi) articles of manufacture containing the compositions (iii) and (iv). | 02-10-2011 |
| 20110028689 | NUCLEIC ACIDS THAT ENCODE SODIUM CHANNEL - A method or screen for assessing the potential of a compound to treat a pathological condition, such as arrhythmia, which is manifested by an increased late sodium current in a heart is disclosed. The method employs a mutant sodium channel protein having an amino acid sequence in which one or more amino acids among the ten amino acids occurring at the carboxy end of the S6 segments of D1, D2, D3 or D4 domains of mammalian Nav1 differs from the amino acid in wild-type Nav1 by substitution with tryptophan, phenylalanine, tyrosine or cysteine. Cells transfected with a nucleic acid that encodes a mutant mammalian Nav1 protein, as well as isolated nucleic acid comprising a nucleotide sequence that codes for a mutant mammalian Nav1 protein are disclosed. | 02-03-2011 |
| 20110028474 | PROTEIN KINASE AND PHOSPHATASE INHIBITORS - The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protein phosphatase inhibitors are provided. The protein kinase or protein phosphatase inhibitors of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, arthrosclerosis, immune system activity, Type II diabetes, and obesity. | 02-03-2011 |
| 20110019791 | SELECTION OF OPTIMAL VIEWS FOR COMPUTED TOMOGRAPHY RECONSTRUCTION - Methods of making iterative low-dose computed tomography (CT) efficient and applicable to clinical practice employ selection of optimal views for CT reconstruction. By optimizing the views for CT reconstruction, the method of the present invention can generate reconstructions at a pre-specified low radiation dose and/or in near real-time. A feature-oriented framework for a task-driven, object-driven, and dose-minimizing selection of X-ray views is provided, which can utilize models of features to be mapped. The models can be derived from a patient population to minimize the dose per exam and/or from a specific patient to minimize the dose per procedure. The method of the present disclosure can be incorporated into a CT system, or can be embodied in a data storage medium as a program. | 01-27-2011 |
| 20110000443 | APPARATUS AND METHOD FOR ULTRASOUND TREATMENT OF AQUATIC ORGANISMS - The invention provides a method of treating a target area with an ultrasound wave pattern, including: providing an ultrasound apparatus having an ultrasound wave generator operatively attached to a plurality of transducers, coupled to an immersible support and configured to emit an ultrasound wave; immersing the apparatus into a water environment; positioning the apparatus proximate to a target area to treat at least one in situ organism; and emitting a pattern of ultrasound waves from the transducers, the pattern of ultrasound waves additive in effect and emitted onto the target area to threat an in situ underwater organism. | 01-06-2011 |
| 20100304983 | METHOD FOR PROTEIN STRUCTURE DETERMINATION, GENE IDENTIFICATION, MUTATIONAL ANALYSIS, AND PROTEIN DESIGN - An efficient computational method and system for predicting the folding regions and associated secondary and tertiary structures of a protein is disclosed. Methods and systems for sorting amino acid sequences based on predicted structures, as well as methods and systems for determining the presence or absence of genes in nucleic acid sequences or structural mutations in amino acid sequences are also disclosed. A method and system for the design of a protein is also disclosed. | 12-02-2010 |
| 20100286314 | POLYOLEFIN NANOCOMPOSITES WITH FUNCTIONAL IONIC LIQUIDS AND CARBON NANOFILLERS - The present disclosure provides polyolefin blends and nanocomposites and methods for their production. In embodiments, a blend or nanocomposite of the present disclosure may include at least one polyolefin and at least one ionic liquid and/or one modified carbon nanofiller. In embodiments, the at least one modified carbon nanotube may be treated with at least one ionic compound. | 11-11-2010 |
| 20100280315 | OPTICAL COHERENCE TOMOGRAPHY SYSTEMS AND METHODS - In general, in one aspect, the invention features a method that includes using an optical coherence tomography system to acquire a plurality of frames of a sample where each frame includes optical information about the composition of the sample through a section of the sample. The method further includes averaging over two or more of the frames to provide an image of the section of the sample where successive frames of the two or more frames are acquired with a time lapse of 0.05-0.7 seconds. Embodiments of the method may have unique advantages for endoscopic subcellular imaging. For example, they can enable subcellular imaging with low-NA optics (e.g., NA=0.25 or less) while providing morphological imaging of the underlying tissue up to 0.6 mm without focal tracking. | 11-04-2010 |
| 20100280223 | METHOD FOR DETERMINING AND PREDICTING PROTEIN AUTONOMOUS FOLDING - Techniques for determining an equilibrium structure of a protein in a predetermined environment, the protein having Ramachandran angles and a known denatured structure, are disclosed. In a preferred embodiment, a method is presented which involves determining a maximum RMS volume of the known denatured structure of the protein and calculating at least one force on the protein in its current structure in the predetermined environment. The net torque resulting from the at least one force for each of the Ramachandran angles of the protein is then determined. Then at least one section of the protein structure on a side of a Ramachandran angle with greatest torque is rotated to form a new structure. A new RMS volume for the new structure is then calculated, and the method is repeated using the new structure. The method ceases when the new RMS volume of the new protein structure is not less than the RMS volume of the starting structure. | 11-04-2010 |
| 20100275276 | ZEBRAFISH MODEL FOR ASSESSING GASTROINTESTINAL MOTILITY - The present invention has demonstrated the presence of the zebrafish KIT protein resulting from the expression of the kit gene in the zebrafish GI tract. As expression of the KIT protein is correlated with ICC in other species, the expression of the KIT protein in zebrafish indicates the presence of ICC in the zebrafish GI tract. ICC are required for spontaneous, coordinated contractions of GI smooth muscle. The present invention provides a zebrafish-based model system useful for elucidating the cellular and molecular mechanisms of gastrointestinal (GI) function and for identifying molecular targets for treating GI motility disorders in human. | 10-28-2010 |
| 20100267645 | Methods and compositions for treating ocular disease - The use of collectins and/or surfactant proteins for the treatment and prevention of ocular disease. | 10-21-2010 |
| 20100266178 | SYSTEM AND METHOD FOR ACCELERATION OF IMAGE RECONSTRUCTION - A method for reconstructing an image from emission data includes generating a compressed point-spread function matrix, generating an accumulated attenuation factor; and performing at least one image projection operation on an image matrix of the emission data using the compressed point-spread function matrix and the accumulated attenuation factor. The image projection operation can include rotating an image matrix and an exponential attenuation map to align with a selected viewing angle. An accumulated attenuation image is then generated from the rotated image matrix and rotated exponential attenuation map and a projection image is generated for each voxel by multiplying the accumulated attenuation image and point spread function matrix for each voxel. The rotating and multiplying operations can be performed on a graphics processing unit, which may be found in a commercially available video processing card, which are specifically designed to efficiently perform such operations. | 10-21-2010 |
| 20100260390 | SYSTEM AND METHOD FOR REDUCTION OF FALSE POSITIVES DURING COMPUTER AIDED POLYP DETECTION - A computer aided detection (CAD) method for detecting polyps within an identified mucosa layer of a virtual representation of a colon includes the steps of identifying candidate polyp patches in the surface of the mucosa layer and extracting the volume of each of the candidate polyp patches. The extracted volume of the candidate polyp patches can be partitioned to extract a plurality of features, of the candidate polyp patch, which includes at least one internal feature of the candidate polyp patch. The features can include density texture features, geometrical features, and morphological features of the polyp candidate volume. The extracted features of the polyp candidates are analyzed to eliminate false positives from the candidate polyp patches. Those candidates which are not eliminated are identified as polyps. | 10-14-2010 |
| 20100233267 | COMPOSITE HYDROGEL - The present invention features a composite hydrogel for use as soft tissue substitutes and transitional three-dimensional support structures. | 09-16-2010 |
| 20100215226 | SYSTEM AND METHOD FOR COMPUTER AIDED POLYP DETECTION - In the present methods, the automatic detection of polyps is converted into a 2D pattern recognition problem using conformal mapping and direct volume rendering. The colon surface is first segmented and extracted from the CT data set of the abdomen, which is then mapped to a 2D plane using conformal mapping. Ray casting is used to determine sub-surface density values and the flattened image is rendered using a volume rendering technique with a translucent electronic biopsy transfer function. Polyp candidates are detected by a clustering method which identifies regions of elevated sub-surface density. The potential for false positives is reduced by analyzing the volumetric shape and texture features of the polyp candidate regions. | 08-26-2010 |
| 20100208956 | ELECTRONIC COLON CLEANSING METHOD FOR VIRTUAL COLONOSCOPY - A method for electronically cleansing a virtual object formed from acquired image data converted to a plurality of volume elements is provided. The present method allows individual volume elements, or voxels, to represent more than one material type. The method includes defining a partial volume image model for volume elements representing a plurality of material types based, at least in part, on the measured intensity value of the volume element. The material mixture for each of the volume elements representing a plurality of material types can be estimated using the observed intensity values and the defined partial volume image model. The volume elements representing a plurality of material types can then be classified in accordance with the estimated material mixture. For electronic colon cleansing, the method includes removing at least one classification of volume elements when displaying the virtual object. | 08-19-2010 |
| 20100190155 | METHODS AND KITS FOR MEASUREMENT OF LYMPHOCYTE FUNCTION - The present invention provides simple and rapid methods for measuring the function of a desired subset of lymphocytes, for example, T cells, B cells or NK cells. In addition, the present invention provides an all-in-one kit that contains reagents which permit a rapid and reliable analysis of the functions of T cells, B cells and NK cells obtained directly from whole blood or cord blood. | 07-29-2010 |
| 20100184970 | Porphyrin-based compounds for tumor imaging and photodynamic therapy - This invention describes a first report on the synthesis of certain | 07-22-2010 |
| 20100173402 | Methods and Compositions for Isolating Metastatic Cancer Cells, and Use in Measuring Metastatic Potential of a Cancer Thereof - The present invention relates to novel methods and compositions for detection and isolation of cancer cells with metastatic potential. The invention further relates to assays for measuring the metastatic potential of such cancer cells and drug screening assays for the identification of agents having anti-metastatic potential. The present invention further provides methods and compositions for inhibiting the metastatic potential of cancer cells by modulating the activity of serine integral membrane proteases [(SIMP) consisting of seprase and dipetidyl peptidase IV (DPPIV)] expressed on the surface of metastasizing cancer cells. | 07-08-2010 |
| 20100172840 | PREPARATION OF CARBON NANOTUBES WITH LANTHANOID CATALYSTS - A lanthanoid metal catalyst for the formation carbon nanotubes from a carbon-containing gas mixture, a method for the formation of carbon nanotubes with the lanthanoid metal catalyst, endohedral carbon nanotube complexes containing lanthanoid metal atoms and/or ions, carbon nanotube imaging contrast agents, and a method for imaging living tissue with carbon nanotube imaging contrast agents are provided. | 07-08-2010 |
| 20100169995 | TARGETED GENE DISRUPTIONS IN THE IQGAP2 GENE - The invention provides a non-human mammal or a cell line that has a targeted gene disruption in an endogenous Iqgap2 gene. The invention also provides methods of identifying a compound as a therapeutic agent for the treatment of hepatocellular carcinoma and methods of treating or preventing hepatocellular carcinoma. | 07-01-2010 |
| 20100167335 | METHODS FOR DIAGNOSING AND TREATING ALLERGIES - The present invention relates to methods of screening actives for the treatment of allergic reactions and providing treatment therefor. In particular, the invention relates to the screening of various antibacterial actives for treatment of asthma and other related symptoms. | 07-01-2010 |
| 20100163715 | Light Focusing in Linear Channel Arrays - The invention relates to devices that contain linear channels having optically transparent substances for focusing light. In some embodiments, the invention relates to improved nucleic acid sequencing methods using devices disclosed herein. In other embodiments, the invention relates to the arrangement of materials in and around capillary tubes with refractive indexes that maximize the number of channels useful for fluorescent detection of compositions after capillary electrophoresis. | 07-01-2010 |
| 20100158809 | TRUNCATED PAP2 AND METHODS OF MAKING AND USING SAME - A method of treating pancreatitis is provided, including the steps of: providing a mammal having pancreatitis; and administering a therapeutically effective amount of a truncated N-terminal PAP2; and making of an antibody specifically directed to detect PAP2. | 06-24-2010 |
| 20100158805 | QUANTUM DOT LABELED STEM CELLS FOR USE IN CARDIAC REPAIR - The present invention provides methods and compositions relating to the labeling of target cells with quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QDs for delivery of a tracking fluorescent signal into the cytosol of target cells via a passive endocytosis-mediated delivery process. In a specific embodiment of the invention the target cell is a stem cell, preferably a mesenchymal stem cell (MSC). Such labeled MSCs provide a means for tracking the distribution and fate of MSCs that have been administered to a subject to promote cardiac repair. The invention is based on the discovery that MSCs can be tracked in vitro for up to at least 6 weeks. Additionally, QDs delivered in vivo can be tracked for up to at least 8 weeks, thereby permitting for the first time, the complete 3-D reconstruction of the locations of all MSCs following administration into a host. | 06-24-2010 |
| 20100152579 | PORTABLE ULTRASONIC DEVICE AND ALGORITHMS FOR DIAGNOSIS OF DENTAL CARIES - Provided is an apparatus and method for the detection of dental caries. The apparatus generates longitudinal ultrasound waves that may be applied to any accessible surface of a tooth. The reflected ultrasound pulse echoes are collected and correlated with the incident pulse. The ultrasound pulse echoes from the front and rear surface of a dental cavity may be distinguished from other echoes, and provided in visual display to inform as to the size and location of the cavity. | 06-17-2010 |
| 20100144636 | PEPTIDES DERIVED FROM RAS-P21 AND USES THEREFOR - A method of treating ras-transformed and ras-related cancer, including: administering to a plurality cells, including ras-transformed cancer cells and normal cells, a peptide material having a membrane resident peptide and a ras-p21 component, the membrane resident peptide attached to the carboxyl or amino terminal end of the ras-p21 component. | 06-10-2010 |
| 20100140154 | GROUP IV METAL OXIDE MONOLITHIC COLUMNS - The present invention discloses methods of preparing a continuous, porous metal oxide monolith in a container. The method involves providing a reaction mixture containing a metal salt or metal alkoxide compound, a solvent, and a porogenic reagent. Next, an epoxide is added to the reaction mixture under conditions effective to initiate condensation and polymerization of the reaction mixture. Then, a container is filled with the reaction mixture after epoxide addition to obtain a continuous, porous metal oxide monolith in the container. The present invention also discloses columns including a tubular container and a continuous, porous Group IV metal oxide monolith in contact with the inner walls of the tubular container, where the Group IV metal oxide monolith is free of any support or matrix material, and other articles including a continuous, porous Group IV metal oxide monolith, where the metal oxide monolith is free of any support or matrix material. | 06-10-2010 |
| 20100133587 | THREE-DIMENSIONAL ARCHITECTURE FOR INTEGRATION OF CMOS CIRCUITS AND NANO-MATERIAL IN HYBRID DIGITAL CIRCUITS - A hybrid CMOL stack enables more efficient design of CMOS logical circuits. The hybrid CMOL structure includes a first substrate having a CMOS device layer on the substrate, a first interconnect layer with interface pins over the CMOS device layer of the first substrate, a first array of nanowires connected to the interface pins of the first interconnect layer, a layer of nanowire junction material over the first array of nanowires, a second array of nanowires over the nanowire junction material, a second interconnect layer having interface pins disposed over the second array of nanowires, the interface pins being connected to the second array of nanowires, and a second substrate, the second substrate including a second CMOS device layer disposed over the second interconnect layer. | 06-03-2010 |
| 20100129861 | Isolation and Use of Novel Mammalian DExH Box Helicases - The present invention relates to the isolation, purification, and use of novel mammalian DExH box helicases. In particular, the present invention relates to the isolation, purification and use of DHX29, a novel mammalian RNA helicase. | 05-27-2010 |
| 20100099749 | Nucleic Acid Inhibitors Of Glutamate Receptors - The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors. | 04-22-2010 |
| 20100099615 | PANCREATIC REGENERATING PROTEIN I IN CHRONIC PANCREATITIS AND AGING IMPLICATIONS FOR NEW THERAPEUTIC APPROACHES TO DIABETES - The present invention provides a method of treating diabetes, including administering to a mammal diagnosed with diabetes a purified recombinant reg I protein. | 04-22-2010 |
| 20100075362 | DEVICE AND METHOD FOR GROWING AND ANALYZING CELLS - A device and method for analyzing cells includes a housing with a chamber, a barrier supported by a frame disposed within the chamber, and a plate arranged at a bottom surface of the housing interior of the chamber. The plate is adapted to receive and sustain cells and the barrier separates the plate into at least two contiguous separate areas. In some embodiments, a thin rubber strip is arranged at the bottom edge of the barrier, which facilitates control of the area in which each cell type is grown, the size of the gap between the cells, and helps prevents over growth of the two cell types on to each other. | 03-25-2010 |
| 20100046370 | SYSTEM AND METHOD FOR FAST, RELIABLE BYTE STREAM TRANSPORT - Reliable byte stream transfer protocols play an important role in modern networks. The present invention implements such a protocol using credits for flow control and negative acknowledgements for reliable delivery. The credit mechanism uses credit transfer in installments and is immune to the losses or corruptions of intermediate credit installments. Negative acknowledgements are used to solicit the retransmission of data stream component. The present invention provides full compatibility at the programming interface with reliable byte transfer protocols, such as TCP, and also allows full interoperability among hosts running the aforesaid standard protocol or the protocol of the present invention. | 02-25-2010 |
| 20100041078 | ANTIBODY-BASED GAMMA-HYDROXYBUTYRATE (GHB) DETECTION METHOD AND DEVICE - Gamma-hydroxybutyrate (GHB) can be used as a recreational party drug, aphrodisiac, and attenuator of other drugs and make a person a vulnerable target of robbery or rape. The present invention provides methods and kits for detection of GHB in a sample using an antibody-based assay. Antibodies that specifically bind to GHB or the conjugates of GHB and its derivatives to larger molecules and methods for detecting GHB or its derivatives in bodily fluids and non-alcoholic and alcoholic drinks by employing such antibodies in ELISA or RIA assays are provided by the present invention. | 02-18-2010 |
| 20100025662 | HIGH DENSITY COUPLING OF QUANTUM DOTS TO CARBON NANOTUBE SURFACE FOR EFFICIENT PHOTODETECTION - The present invention relates to a method of preparing a carbon nanotube-quantum dot conjugate having a high density of quantum dots (QDs) on its surface. This method involves providing a plurality of semiconductor quantum dots and providing a thiol-functionalized carbon nanotube having a plurality of terminal thiol groups on its surface. The plurality of semiconductor quantum dots are attached to the surface of the carbon nanotube under conditions effective to yield a carbon nanotube-quantum dot conjugate having a high density of quantum dots on its surface. The present invention also relates to a carbon nanotube-quantum dot conjugate having a high density of quantum dots on its surface. The present invention further relates to a photodetector device. This device includes a substrate and a nanocomposite layer. The nanocomposite layer includes a plurality of the carbon nanotube-quantum dot conjugates previously described. | 02-04-2010 |
| 20100017638 | System and Method for Reducing Power Requirements of Microprocessors Through Dynamic Allocation of Datapath Resources - There is provided a system and methods for segmenting datapath resources such as reorder buffers, physical registers, instruction queues and load-store queues, etc. in a microprocessor so that their size may be dynamically expanded and contracted. This is accomplished by allocating and deallocating individual resource units to each resource based on sampled estimates of the instantaneous resource needs of the program running on the microprocessor. By keeping unused datapath resources to a minimum, power and energy savings are achieved by shutting off resource units that are not needed for sustaining the performance requirements of the running program. Leakage energy and switching energy and power are reduced using the described methods. | 01-21-2010 |
| 20100010186 | High Strength Polyethylene Fiber - The present invention provides a high strength polyethylene fiber having an intrinsic viscosity of from about 5 dL/g to 40 dL/g, and containing carbon nanofiber modified with alkyl chains. The fiber obtained by the production method of a high strength polyethylene fiber of the present invention is industrially applicable to a wide range and greatly contributes to the industry. | 01-14-2010 |
| 20090306748 | BODY THERMAL REGULATION/MEASUREMENT SYSTEM - The present invention relates to a body thermal regulation system. The system includes a fluid-circulating garment having a plurality of fluid-impervious compartments where each compartment is in contact with a different part of a body. The system also includes an expandable bladder to accommodate changes in pressure in the fluid circulation system. At least one heating/cooling unit is positioned to heat and/or cool fluid circulating to the fluid-impervious compartments in the garment. The system also includes a fluid circulation system positioned to circulate fluid between the heating/cooling unit and the plurality of fluid-impervious compartments in the garment. The present invention also relates to a method for measuring heat fluxes in different parts of a body. The method involves providing to a subject the body thermal regulation system according to the present invention. Then, the temperatures and flow rates of fluid entering and exiting each of the plurality of fluid-impervious compartments in the garment are measured, allowing heat fluxes in different parts of the body to be determined. | 12-10-2009 |
| 20090298101 | Blood C5a Levels as an Indicator of Rhinoconjunctivitis Severity - The present invention provides methods of determining the severity of rhinoconjunctivitis in a patient by determining the levels of C5a or C5a-desArg in the patient's blood, plasma or serum. | 12-03-2009 |
| 20090296057 | AUTOMATED DETERMINATION OF HEIGHT AND TILT OF A SUBSTRATE SURFACE WITHIN A LITHOGRAPHY SYSTEM - Method and apparatus are provided for automated determination and adjustment of height and tilt of a substrate surface within a lithography system. The method includes: directing a beam of light onto the substrate surface, which reflects off the substrate surface as a reflected beam; optically splitting the reflected beam into a first reflected beam portion and a second reflected beam portion; impinging the first reflected beam portion onto a first detector plane of a first optical detector to generate intensity data, and impinging the second reflected beam portion onto a second detector plane of a second optical detector to generate intensity data, and utilizing the generated data in determining height and tilt of the substrate surface relative to a nominal writing plane of the lithography system. Responsive to the determination, focus or tilt of the system's writing beam, or position of the substrate surface within the system, is adjusted. | 12-03-2009 |
| 20090286861 | PHENOTYPIC REVERSION OF PANCREATIC CARCINOMA CELLS - The present invention provides peptides (including analogs and derivatives thereof) corresponding to residues 96-110 and 35-47 of ras-p21, which peptides have attached thereto a membrane-penetrating leader sequence. The subject peptides, analogs and derivatives thereof are useful in treatment of cancers and have been shown to induce phenotypic reversion of pancreatic cancer cells to non-cancerous cells. Pharmaceutical compositions comprising one or more subject peptides are also provided by the present invention. The present invention further provides replication incompetent Adenovirus (AdV) vectors comprising a promoter sequence and a nucleotide sequence encoding a subject peptide. Methods of treating cancer by administering one or more subject peptides, pharmaceutical compositions, and/or AdV vectors are also provided. | 11-19-2009 |
| 20090286244 | Fluorescent Color Markers - The invention provides a yeast-enhanced red fluorescent protein. In an embodiment of the invention, the yeast-enhanced red fluorescent protein is monomeric and is expressible in | 11-19-2009 |
| 20090269795 | Mutant alpha4betadelta GABAA receptor and methods of treating anxiety or irritability - The present invention provides methods for treating anxiety or irritability in a subject. The methods comprise administering to the subject an effective amount of an antagonist of allopregnanolone (THP), or a regulator which decreases expression of the alpha 4 subunit of GABA such as gabadoxbol (THIP), or a vector comprising an isolated nucleic acid molecule encoding a mutant alpha 4 subunit GABA | 10-29-2009 |
| 20090269604 | COMPOSITE THERMAL INTERFACE MATERIAL SYSTEM AND METHOD USING NANO-SCALE COMPONENTS - A method of manufacturing a thermal interface material, comprising providing a sheet comprising nano-scale fibers, the sheet having at least one exposed surface; and stabilizing the fibers with a stabilizing material disposed in at least a portion of a void space between the fibers in the sheet. The fibers may be CNT's or metallic nano-wires. Stabilizing may include infiltrating the fibers with a polymerizable material. The polymerizable material may be mixed with nano- or micro-particles. The composite system may include two films, with the fibers in between, to create a sandwich. Each capping film may include two sub films: a palladium film closer to the stabilizing material to improve adhesion; and a nano-particle film for contact with a device to be cooled or a heat sink. | 10-29-2009 |
| 20090264528 | SERINE PALMITOYLCOA TRANSFERASE (SPT) INHIBITION BY MYRIOCIN OR GENETIC DEFICIENCY DECREASES CHOLESTEROL ABSORPTION - A first aspect of the invention provides a method of screening cholesterol absorption inhibitors, including: administering to a mammal a biologically effective amount of a candidate SPT inhibitor; and determining whether an amount at least one cholesterol absorption indicator protein in the intestine has changed after the administering step. | 10-22-2009 |
| 20090264514 | SPHINGOMYELIN SYNTHASE 2 (SMS2) DEFICIENCY ATTENUATES NFkB ACTIVATION, A POTENTIAL ANTI-ATHEROGENIC PROPERTY - The present invention is directed to a method of screening for NFκB inhibiting agents, the method including the steps of administering a biologically effective amount of a candidate SMS2 inhibitor to at least one cell; and determining whether the candidate SMS2 inhibitor inhibits NFκB. | 10-22-2009 |
| 20090262958 | COMB SENSE MICROPHONE - A miniature microphone, comprising a diaphragm, supported for displacement in response to acoustic waves, from which a plurality of projections extend; a plurality of projections extending from a surface; a body, supporting the surface to maintain the plurality of projections from the diaphragm and the plurality of projections from the surface in close proximity; and an electromagnetic sensor adapted to sense an electromagnetic interaction between the plurality of projections from the diaphragm and the plurality of projections from the surface and produce an electrical signal in response thereto. The interaction may be detected substantially without inducing a force which tends to substantially displace the diaphragm, since the electrostatic force is substantially parallel to the diaphragm surface. | 10-22-2009 |
| 20090246216 | NOVEL ATTENUATED POLIOVIRUS - A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2a | 10-01-2009 |
| 20090237614 | APPARATUS AND METHOD FOR ASSESSING RETINAL DAMAGE - The invention administers an objective clinical test to an eye that measures the visual sensitivity of the superior retina and the inferior retina, by alternately presenting a stimulus pair comprising a shaped superior light stimulus and a shaped inferior light stimulus that are horizontal mirror images of one another and have shapes encompassing visual field defects. The shaped superior and inferior light stimuli stimulate pupillary responses whose amplitudes are measured. A cycle-averaged pupillary response balance and a luminance ratio are computed for each presentation of a stimulus pair. A stimulus pair response curve is computed by fitting cycle-averaged pupillary response balances to a sigmoid function of the luminance ratios. A balanced luminance ratio at which the cycle-averaged pupillary response balance is equal to about zero is computed from the sigmoid function. The balanced luminance ratio is indicative of the presence and location of retinal nerve damage. | 09-24-2009 |
| 20090233330 | Method and apparatus for measuring changes in cell volume - A method and apparatus for measuring changes in cell volume generally includes introducing cells into a chamber having a volume between 2 and 100 times the volume of the introduced cell. A first electrically conductive extracellular fluid is introduced into the chamber and a current is applied. The voltage induced by said current flow is measured. The first fluid is exchanged with a second electrically conductive extracellular fluid and a current is applied. The voltage induced by said current flow is measured. The first induced voltage result and the second induced voltage result are used in conjunction with known voltages induced by such current flows to monitor changes in the volume corresponding to fluid flow between the cell and an extracellular fluid. | 09-17-2009 |
| 20090232991 | COMPOSITE THERMAL INTERFACE MATERIAL SYSTEM AND METHOD USING NANO-SCALE COMPONENTS - A method of manufacturing a thermal interface material, comprising providing a sheet comprising nano-scale fibers, the sheet having at least one exposed surface; and stabilizing the fibers with a stabilizing material disposed in at least a portion of a void space between the fibers in the sheet. The fibers may be CNT's or metallic nano-wires. Stabilizing may include infiltrating the fibers with a polymerizable material. The polymerizable material may be mixed with nano- or micro-particles. The composite system may include two films, with the fibers in between, to create a sandwich. Each capping film may include two sub films: a palladium film closer to the stabilizing material to improve adhesion; and a nano-particle film for contact with a device to be cooled or a heat sink. | 09-17-2009 |
| 20090207413 | OPTICAL METHODS AND SYSTEMS FOR DETECTING A CONSTITUENT IN A GAS CONTAINING OXYGEN IN HARSH ENVIRONMENTS - A method for detecting a gas phase constituent such as carbon monoxide, nitrogen dioxide, hydrogen, or hydrocarbons in a gas comprising oxygen such as air, includes providing a sensing material or film having a metal embedded in a catalytically active matrix such as gold embedded in a yttria stabilized zirconia (YSZ) matrix. The method may include annealing the sensing material at about 900° C., exposing the sensing material and gas to a temperature above 400° C., projecting light onto the sensing material, and detecting a change in the absorption spectrum of the sensing material due to the exposure of the sensing material to the gas in air at the temperature which causes a chemical reaction in the sensing material compared to the absorption spectrum of the sensing material in the absence of the gas. Systems employing such a method are also disclosed. | 08-20-2009 |
| 20090203122 | Peripheral nervous system specific sodium channels, DNA encoding therefor, crystallization, x-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof - Cloning, expression, viral and delivery vectors and hosts which contain nucleic acid coding for at least one peripheral nervous system specific (PNS) sodium channel peptide (SCP), isolated PNS SCP, and compounds and compositions and methods, are provided, for isolating, crystallizing, x-ray analysing molecular modeling, rational drug designing, selecting, making and using therapeutic or diagnostic agents or ligands having at least one peripheral nervous system specific (PNS) sodium channel (SC) modulating activity. | 08-13-2009 |
| 20090202538 | F11 RECEPTOR (F11R) ANTAGONISTS AS THERAPEUTIC AGENTS - The present invention provides a cell adhesion molecule (CAM), designated F11 receptor (F11R) and its use to inhibit platelet aggregation and platelet adhesion for the treatment and prevention of cardiovascular disorders. Cloned F11R cDNA and full length F11R cDNA and amino acid sequences are provided. F11R-antagonists and methods for the prevention and treatment of thrombosis, atherosclerosis, heart attacks, stroke and other clinical disorders involving thrombus formation are also provided. There are at least two kinds of antagonists that may be employed together. Peptides derived from the extracellular domain of F11R and small molecules and peptidomimetics based on the structure of these peptides, as well as inhibitory antibodies and functional fragments thereof, are shown to inhibit human platelet aggregation and platelet adhesion to endothelial cells, and therefore, inhibit the formation of atherosclerotic plaques. | 08-13-2009 |
| 20090197947 | MEDICAMENTS AND METHODS FOR LOWERING PLASMA LIPID LEVELS AND SCREENING DRUGS - The invention relates to compositions, medicaments, methods for treating individuals with high plasma lipid levels, and methods for screening drug candidates useful in, for example, the treatment of hypercholesterolemia. Specifically, the invention relates to the discovery that MTP inhibition leads to increased accumulation in cellular free-cholesterol and is useful in the development of compositions, medicaments, methods of treatment and drug screening methods to treat high plasma lipid levels. | 08-06-2009 |
| 20090170779 | F11 Receptor (F11R) Antagonists as Therapeutic Agents - The present invention provides a cell adhesion molecule (CAM), designated F11 receptor (F11R), which is a member of the immunoglobulin super family localized on the surface of human platelets, and determined to effect platelet aggregation, secretion, platelet spreading and cellular adhesion. Cloned F11R cDNA and full length F11R cDNA and amino acid sequences are provided. F11R-antagonists and methods for the prevention and treatment of thrombosis, atherosclerosis, heart attacks, stroke and other clinical disorders involving thrombus formation are also provided. | 07-02-2009 |
| 20090148877 | ENZYMATIC METHODS FOR MEASURING PLASMA AND TISSUE SPHINGOMYLELIN AND PHOSPHATIDYLCHOLINE - A method for measuring sphingomyelin and phosphatidylcholine comprising incubating sphingomyelin and phosphatidylcholine with bacterial sphingomyelinase and bacterial phospholipase D, alkaline phosphatase, choline oxidase, peroxidase, N-Ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline, and 4-aminoantipyrine, preferably for about 45 minutes. A blue dye is generated. | 06-11-2009 |
| 20090112094 | Phased Apply Ultrasound With Electronically Controlled Focal Point For Assessing Bone Quality Via Acoustic Topology And Wave Transmit Functions - A surface topology map technique and apparatus are disclosed for determining calcaneus thickness for imaging quantitative ultrasound measurements; improving measurement accuracy, particularly in in vivo applications. | 04-30-2009 |
| 20090103102 | SYSTEMS AND METHODS FOR DIGITAL DETECTION OF A TOMOGRAPHIC SIGNAL - Systems and methods for digital detection of an analog tomographic signal are described. The methods include receiving an amplitude-modulated analog signal containing tomographic information, the analog signal having a modulation frequency, f | 04-23-2009 |
| 20090083390 | AUTOMATIC CLUSTERING FOR SELF-ORGANIZING GRIDS - Computational grids have traditionally not scaled effectively due to administrative hurdles to resource and user participation. Most production grids are essentially multi-site supercomputer centers, rather than truly open and heterogeneous sets of resources that can join and leave dynamically, and that can provide support for an equally dynamic set of users. Large-scale grids containing individual resources with more autonomy about when and how they join and leave will require self-organizing grid middleware services that do not require centralized administrative control. Dynamic discovery of high-performance variable-size clusters of grid nodes provides an effective solution for implementation of grids. A brute force approach to the problem of identifying these “ad-hoc clusters” would require excessive overhead in terms of both message exchange and computation. Therefore, a scalable solution is provided that uses a delay-based overlay structure to organize nodes based on their proximity to one another, using a small number of delay experiments. This overlay can then be used to provide a variable-size set of promising candidate nodes than can then be used as a cluster, or tested further to improve the selection. Simulation results show that this approach results in effective clustering with acceptable overhead. | 03-26-2009 |
| 20090075291 | PEPTIDE-BASED REGULATION OF GAP JUNCTIONS - The present invention relates to proteins and polypeptides that (i) have the formula A-[W | 03-19-2009 |
| 20090069230 | GDNF-DERIVED PEPTIDES - Compositions that include peptides derived from glial-derived neurotrophic factor (GDNF) (e.g., substantially pure polypeptides comprising a fragment of a GDNF precursor protein) and biologically active variants thereof are provided. The compositions can include one or more types of peptides and can include other substances (e.g., pharmaceutically acceptable carriers or diluents or liposomes). Also provided are methods for using the compositions for treatment of neurological disorders (e.g., motor system disorders and sensory system disorders). | 03-12-2009 |
| 20090062205 | Reconstitution Medium For Protein and Peptide Formulations - Compositions useful for reconstitution of concentrated formulations containing protein/peptide pharmaceuticals are provided. The composition generally includes one or more lipids, as well as one or more alcohols that promote and stabilize the formation of (a) lipid molecular assemblies with greater protein encapsulation; (b) protein-lipid complexes and (c) protein and lipid solutions. The reconstitution medium improves the protein-lipid association that in turn alters the pharmaceutical properties. | 03-05-2009 |
| 20090053297 | COMPOSITIONS AND METHODS FOR LESS IMMUNOGENIC PROTEIN-LIPID COMPLEXES - The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phosphatidyl ethanolamine. | 02-26-2009 |
| 20090050201 | SOLAR CELL - Disclosed is a photovoltaic solar cell and method for producing same for conversion of light into electric power using a composite film having micron sized down to nanometer sized particles sufficiently sized for precise light scattering. A matrix material is further provided having a substantially different refractive index to provide a refractive index contrast for light scattering. | 02-26-2009 |
| 20090046883 | SURFACE MICROMACHINED DIFFERENTIAL MICROPHONE - A differential microphone having a perimeter slit formed around the microphone diaphragm that replaces the backside hole previously required in conventional silicon, micromachined microphones. The differential microphone is formed using silicon fabrication techniques applied only wafer. The backside holes of prior art microphones typically require that a secondary machining operation be performed on the rear surface of the silicon wafer during fabrication. This secondary operation adds complexity and cost to the micromachined microphones so fabricated. Comb fingers forming a portion of a capacitive arrangement may be fabricated as part of the differential microphone diaphragm. | 02-19-2009 |
| 20090041781 | METHODS FOR DETECTING PARVOVIRUS INFECTIONS - The present invention provides a method for diagnosing a subject suffering a pathological condition characterized by parvovirus infection by detecting the presence of IgE anti-Parvovirus B 19 antibodies. | 02-12-2009 |
| 20090034561 | BACKWARD STIMULATED RAYLEIGH-BRAGG SCATTERING DEVICES BASED ON MULTI-PHOTON ABSORBING MATERIALS AND THEIR APPLICATIONS - The present invention relates to a method and system of generating backward stimulated Rayleigh-Bragg scattering by focusing activating radiation through a multi-photon absorbing dye solution, thereby producing coherent output radiation with no measured frequency shift and measured pump threshold values independent of the spectral line width of the input activating radiation. | 02-05-2009 |
| 20090033326 | SIMULTANEOUSLY CYCLED NMR SPECTROSCOPY - The present invention relates to a method for simultaneously conducting multiple steps of a cycle of a nuclear magnetic resonance (NMR) experiment without the use of pulsed magnetic field gradients during signal detection in which one or more spatially selective radiofrequency pulses are applied to a sample under conditions effective to simultaneously spatially distribute the radiofrequency power associated with each of the cycle steps to a plurality of spatially discrete sections within the sample such that each section executes an individual step of the cycle and the resultant NMR signals from each of the cycle steps are produced simultaneously. | 02-05-2009 |
| 20090029415 | Peripheral nervous system specific sodium channels, DNA encoding therefor, crystallization, X-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof - Cloning, expression, viral and delivery vectors and hosts which contain nucleic acid coding for at least one peripheral nervous system specific (PNS) sodium channel peptide (SCP), isolated PNS SCP, and compounds and compositions and methods, are provided, for isolating, crystallizing, x-ray analysing molecular modeling, rational drug designing, selecting, making and using therapeutic or diagnostic agents or ligands having at least one peripheral nervous system specific (PNS) sodium channel (SC) modulating activity. | 01-29-2009 |
| 20090023953 | PENTAFLUOROSULFANYL CONTAINING AMINO ACIDS - There are provided SF | 01-22-2009 |
| 20090010918 | METHODS FOR TREATMENT USING COLLAGENASE - Methods for treatment by collagenase injections are provided, which are effective in dissolving and lysing a collagenase septa network to treat carpal tunnel, plantar fasciitis and lateral epicondylitis conditions. The methods treat such conditions by injecting or otherwise delivering purified collagenase to the afflicted region of the patient, as well as use of collagenase for manufacture of a medicament for such conditions. | 01-08-2009 |
| 20090009166 | METHOD OF USING G-MATRIX FOURIER TRANSFORMATION NUCLEAR MAGNETIC RESONANCE (GFT NMR) SPECTROSCOPY FOR RAPID CHEMICAL SHIFT ASSIGNMENT AND SECONDARY STRUCTURE DETERMINATION OF PROTEINS - The present invention presents a new approach to rapidly obtaining precise high-dimensional NMR spectral information, named “GFT NMR spectroscopy”, which is based on the phase sensitive joint sampling of the indirect dimensions spanning a subspace of a conventional NMR experiment. The phase-sensitive joint sampling of several indirect dimensions of a high-dimensional NMR experiment leads to largely reduced minimum measurement times when compared to FT NMR. This allows one to avoid the “sampling limited” data collection regime. Concomitantly, the analysis of the resulting chemical shift multiplets, which are edited by the G-matrix transformation, yields increased precision for the measurement of the chemical shifts. Additionally, methods of conducting specific GFT NMR experiments as well as methods of conducting a combination of GFT NMR experiments for rapidly obtaining precise chemical shift assignment and determining the structure of proteins or other molecules are disclosed. | 01-08-2009 |
| 20090002627 | OPTICAL ELEMENTS HAVING VARIABLE POWER PRISMS - Optical elements having a plurality of integral prism facets having varying prismatic power are provided. These optical elements address the disadvantages of conventional therapeutic optical prisms by addressing the undesirable variation in prismatic effect that results when conventional prisms are combined with optical lenses in binocular vision. Specifically, the present invention can equalize differential prismatic effects of right and left eye lenses over their entire aperture. The optical elements may include a plurality of prism facets having base-down and base-up prismatic power. The elements may include individual elements having variable prismatic elements, individual elements combining both conventional prisms and variable prism, or separate elements having conventional prisms and variable prism. The plurality of integral facets or a substantially continuous smooth surface may be provided, for, example, a cylindrical surface having a circular or non-circular profile. Methods of correcting binocular vision are also disclosed. | 01-01-2009 |
| 20080312470 | Mono, Di & Tri Cyclic Compounds Useful for Lowering IgE Concentrations - The present invention is directed to novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic. | 12-18-2008 |
| 20080294686 | SPECTRAL CLUSTERING FOR MULTI-TYPE RELATIONAL DATA - A general model is provided which provides collective factorization on related matrices, for multi-type relational data clustering. The model is applicable to relational data with various structures. Under this model, a spectral relational clustering algorithm is provided to cluster multiple types of interrelated data objects simultaneously. The algorithm iteratively embeds each type of data objects into low dimensional spaces and benefits from the interactions among the hidden structures of different types of data objects. | 11-27-2008 |
| 20080287815 | Photoplethysmography apparatus and method employing high resolution estimation of time-frequency spectra - A photoplethysmography apparatus and method is provided for high resolution estimating of Time-Frequency Spectra (TFS) and associated amplitudes using Variable Frequency Complex Demodulation (VFCDM), in a two-step procedure using a Time-Varying Optimal Parameter Search (TVOPS) technique to obtain TFS, followed by VFCDM to obtain even greater TFS resolution and instantaneous amplitudes associated with only specific frequencies of interest, via the combined TVOPS and VFCDM. | 11-20-2008 |
| 20080281819 | NON-RANDOM CONTROL DATA SET GENERATION FOR FACILITATING GENOMIC DATA PROCESSING - Processing of genomic data is facilitated by providing a control data set generation system wherein a control generator tool or process creates matched data sets for facilitating informatics analysis. These matched data sets may include genomic loci or genomic sequences, or both. The data is taken from a database of actual genomic data, including sequence and annotation data, as opposed to ad-hoc generation, sequence scrambling or the like. This produces biologically relevant and accurate results which allow for stronger controls. The controls are matched against a user-provided data set via a number of parameters. | 11-13-2008 |
| 20080281818 | SEGMENTED STORAGE AND RETRIEVAL OF NUCLEOTIDE SEQUENCE INFORMATION - Processing of genomic data is facilitated by providing a storage device with a database having a segmented sequence table. The table has a plurality of data subsets of common nucleotide sequence size n, wherein≧2, and each data subset of common nucleotide sequence n is separately indexed within the table. A database manager associated with the database retrieves a selected nucleotide sequence locus from the table. The selected nucleotide sequence locus is sized differently from the common nucleotide sequence size n, and the retrieving includes identifying each data subset of the segmented sequence table containing at least a portion of the selected nucleotide sequence locus, and retrieving the identified data subsets. The database manager processes the retrieved, identified data subsets to remove genomic data mapped to the nucleotide positions outside the selected nucleotide sequence locus, and outputs the selected nucleotide sequence locus. | 11-13-2008 |
| 20080281530 | GENOMIC DATA PROCESSING UTILIZING CORRELATION ANALYSIS OF NUCLEOTIDE LOCI - Processing of genomic data is provided utilizing correlation analysis of first and second nucleotide loci employing a selected comparison type and value. The comparison type is either intersection or proximity type, and the comparison value is either a number (n) of nucleotide positions, wherein n≧1, or a percent number (pn) of nucleotide positions, wherein pn≧0, to be employed in comparing the loci. When intersection type is selected, correlation is defined by the loci overlapping with at least the number (n) of nucleotide positions in common, or by the loci overlapping with at least the percent number (pn) of nucleotide positions in common relative to a smaller one of the first and second loci, or when proximity type is selected, correlation is defined by the first and second loci being within at least the number (n) of nucleotide positions. | 11-13-2008 |
| 20080281529 | GENOMIC DATA PROCESSING UTILIZING CORRELATION ANALYSIS OF NUCLEOTIDE LOCI OF MULTIPLE DATA SETS - Processing of genomic data is facilitated utilizing correlation analysis of mapped data sets, each data set including genomic data mapped and ordered relative to a genomic coordinate system. Correlation analysis identifies at a nucleotide level nucleotide positions wherein at least one nucleotide locus of each data set correlate. The analysis includes for each data set, selecting a nucleotide locus thereof closest to one end of the coordinate system, comparing the selected nucleotide loci for correlation, and if so, outputting results of the comparing, and updating the selected nucleotide loci by identifying the data set having a next nucleotide locus closest to the one end of the coordinate system, and inserting that next locus into the group of selected loci, and repeating the comparing for the newly selected loci. The process is repeated until nucleotide loci of the mapped data sets are compared and results of the comparison are output. | 11-13-2008 |
| 20080281181 | Combination of Multi-Modality Imaging Technologies - Different applications for multiple imaging technologies are provided to advance patient care. In one aspect, a 3-D imaging device is used to identify the location of target region in a patient, such as a tumor or aneurysm, for instance. The location information is then used to control a device used in performing a surgical or other intervention, further imaging or a diagnostic or therapeutic procedure ( | 11-13-2008 |
| 20080267231 | DETUNED DUO-CAVITY LASER-MODULATOR DEVICE AND METHOD WITH DETUNING SELECTED TO MINIMIZE CHANGE IN REFLECTIVITY - A detuned duo-cavity laser-modulator device and method are provided which include lower, middle and upper reflectors, a gain region and an absorber region integrated into a semiconductor die. The middle reflector is disposed between the lower and upper reflectors. Together, the lower and middle reflectors define a first resonant cavity, while the upper and middle reflectors define a second resonant cavity. A gain region is disposed within a laser cavity of the resonant cavities to generate an optical carrier wave, while an absorber region is disposed within a modulator cavity of the resonant cavities to modulate a signal on the optical carrier wave. The laser and modulator cavities are detuned resonant cavities, with the detuning of the laser and modulator cavities being selected to minimized change in reflection from the modulator cavity to the laser cavity when the absorber region modulates the signal on the optical carrier wave. | 10-30-2008 |
| 20080257830 | APPARATUS AND METHOD FOR ULTRASOUND TREATMENT OF AQUATIC ORGANISMS - The invention provides a method of treating a target area with an ultrasound wave pattern, including: providing an ultrasound apparatus having an ultrasound wave generator operatively attached to a plurality of transducers, coupled to an immersible support and configured to emit an ultrasound wave; immersing the apparatus into a water environment; positioning the apparatus proximate to a target area to treat at least one in situ organism; and emitting a pattern of ultrasound waves from the transducers, the pattern of ultrasound waves additive in effect and emitted onto the target area to threat an in situ underwater organism. | 10-23-2008 |
| 20080249174 | Animal Model for Studying Atherosclerotic Lesions - The present invention provides an animal model for atherosclerosis and a transgenic knockout animal. Methods for preventing and/or treating atherosclerosis are also provided. More specifically, the present invention provides methods of preventing and/or treating atherosclerosis by administering to a subject in need thereof an inhibitor of Serine palmitoyl-CoA transferase (SPT) or its subunit. | 10-09-2008 |
| 20080247998 | Creation of a Biological Atrioventricular Bypass to Compensate for Atrioventricular Block - A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle. | 10-09-2008 |
