| THE REGENTS OF THE UNIVERSITY OF MICHIGAN Patent applications |
| Patent application number | Title | Published |
|---|
| 20120135950 | ANTIVIRAL TREATMENT OF LYMPHOMA AND CANCER - Compositions and methods to treat lymphoma and cancer are disclosed. In particular, the method teaches treatment of lymphoma and cancer using anti-HERV-K(HML-2) therapies. Further taught are compositions and methods for characterizing patient samples to, for example, select or identify therapeutic options or assess the impact of therapies. | 05-31-2012 |
| 20120135884 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING MACULAR DEGENERATION - The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications. | 05-31-2012 |
| 20120135416 | Compositions And Methods For Treating And Diagnosing Pancreatic Cancer - The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides pancreatic cancer stem cells useful for the study, diagnosis, and treatment of solid tumors. | 05-31-2012 |
| 20120128719 | STREPTOCOCCUS VACCINE COMPOSITIONS AND METHODS OF USING THE SAME - The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides immunogenic nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against a bacterial species of the genus | 05-24-2012 |
| 20120126449 | SHAPING NANOSTRUCTURE ARRAYS - Nanostructured assemblies are manufactured by condensing an evaporated wetting agent onto a nanostructure array formed from a plurality of generally aligned carbon nanotubes or other nanostructures. The condensed wetting agent draws the individual nanostructures together to form various geometries of nanostructured assemblies based on various parameters including process variables and the starting shape and dimensional features of the nanostructure array. Various simple and complex geometries can be achieved in this manner, including geometries that are curved, bent, or twisted. Adjacent nanostructure arrays of the same or different starting geometries can be shaped into compound or interrelating structures. Additional process steps such as plasma etching, coating and others can be used to control the shaping and structural attributes of the nanostructured assemblies. A method of making a molded replica of a shaped nanostructure array is also disclosed. | 05-24-2012 |
| 20120122947 | SPIRO-OXINDOLE MDM2 ANTAGONISTS - Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases. | 05-17-2012 |
| 20120121571 | Lysosomal Phospholipase A2 (LPLA2) Activity as a Diagnostic and Therapeutic Target for Identifying and treating Systemic Lupus Erythematosis - The present invention is directed to methods for diagnosis and treatment of systemic lupus erythematosus and drug-induced systemic lupus erythematosus. More specifically, the specification describes methods using a lysosomal phospholipase A2 in methods for the diagnosis and treatment of autoimmune disorders such as systemic lupus erythematosus and drug-induced systemic lupus erythematosus. | 05-17-2012 |
| 20120114623 | ANTIGEN-SPECIFIC LONG-TERM MEMORY T-CELLS - The present invention provides compositions, methods, and systems for generating antigen-specific long-term memory T-cells using mTOR pathway inhibitors. The present invention provides compositions, systems, and methods for administering antigen-specific long-term memory T-cells to a subject (e.g., to a subject with cancer in adoptive transfer type of procedures). | 05-10-2012 |
| 20120107349 | MULTIVALENT NANOEMULSION VACCINES - The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods of inducing an immune response against one or a plurality of pathogens (e.g., vaccinia virus, H5N1 influenza virus, | 05-03-2012 |
| 20120101092 | SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF - The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s). | 04-26-2012 |
| 20120100107 | IN VIVO TRANSFER METHODS FOR WOUND HEALING - The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest. | 04-26-2012 |
| 20120094982 | 1,4-BENZODIAZEPINONE COMPOUNDS AND THEIR USE IN TREATING CANCER - The invention provides a family of 1,4-benzodiazepinone compounds and methods for their use as therapeutic agents in treating cancer. Pharmaceutical compositions and methods of making the 1,4-benzodiazepinone compounds are provided. | 04-19-2012 |
| 20120091436 | ORDERED ORGANIC-ORGANIC MULTILAYER GROWTH - An ordered multilayer crystalline organic thin film structure is formed by depositing at least two layers of thin film crystalline organic materials successively wherein the at least two thin film layers are selected to have their surface energies within ±50% of each other, and preferably within ±15% of each other, whereby every thin film layer within the multilayer crystalline organic thin film structure exhibit a quasi-epitaxial relationship with the adjacent crystalline organic thin film. | 04-19-2012 |
| 20120088757 | NOVEL 1,4-BENZODIAZEPINE-2,5-DIONES WITH THERAPEUTIC PROPERTIES - The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides novel 1,4-benzodiazepine-2,5-dione compounds, and methods of using novel 1,4-benzodiazepine-2,5-dione compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like. | 04-12-2012 |
| 20120087061 | Transition Metal Carbide or Nitride or Boride Based Supercapacitors with Metal Foam Electrode Substrate - In accordance with an embodiment of the disclosure, a method of making a supercapacitor includes impregnating a foam electrode substrate with an active material precursor, wherein the foam electrode substrate includes a plurality of pores and the active material precursor is dispersed into the pores. The method further includes reacting the active material precursor infiltrated foam substrate with a reductant under conditions sufficient to convert the active material precursor to an active material, wherein the active material is based on a nitride, an oxynitride, a carbide, or an oxycarbide of a metal selected from Groups III, IV, V, VI, or VII of the Periodic Table. | 04-12-2012 |
| 20120077806 | Deubiquitinase Inhibitors and Methods for Use of the Same - Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds. | 03-29-2012 |
| 20120077805 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS - The present invention relates to systems and methods for generating new forms of benzodiazepine and benzodiazepine related compounds as well as new compounds and formulations generated by such methods. In particular, the present invention provides high throughput systems and methods for generating and identifying new crystalline benzodiazepine and benzodiazepine related polymorphs and new unsolvated, solvated, and other forms of the compounds that find use as improved drugs and drug formations. | 03-29-2012 |
| 20120070389 | METHODS FOR IDENTIFYING TREATMENTS THAT TREAT AND/OR PREVENT UV IRRADIATION INDUCING PHOTOAGING - Methods are provided for ascertaining and measuring RPTP-κ activity in response to insults such as UV irradiation and with respect to administration of a treatment and/or composition. Attenuation of EGFR activity by RPTP-κ affects aspects of photoaging, including damage to the skin, suppression of the immune system, DNA damage, and connective tissue degradation. Intervention with respect to the effects of photoaging can include protection of RPTP-κ from oxidation. The methods can be used for discovery of anti-aging treatments, adjuncts, or other preventative treatments, such as sunscreens. | 03-22-2012 |
| 20120061658 | STRUCTURAL TEMPLATING FOR ORGANIC ELECTRONIC DEVICES HAVING AN ORGANIC FILM WITH LONG RANGE ORDER - An organic photosensitive device having an organic film with a desired crystalline order includes a first electrode layer and at least one structural templating layer disposed on the first electrode A photoactive region is disposed on the templating layer and includes a donor material and an acceptor material, wherein the donor or the acceptor is templated by the templating layer, and further wherein a majority of the molecules of the templated material are in a non-preferential orientation with respect to the first electrode An organic light emitting device incorporating such organic films includes a first electrode layer, a second electrode layer, at least one structural templating layer disposed between the first and second electrodes, and a functional layer disposed over the templating layer A majority of the molecules of the functional layer are in a non-preferential orientation with respect to the layer below the templating layer | 03-15-2012 |
| 20120059779 | Personalized Health Risk Assessment For Critical Care - A method for assessing whether a patient is at risk of developing a clinical condition includes receiving training data representing a set of patient-related variables for each of a plurality of patients; generating model data based on the received training data; receiving target data representing the set of patient-related variables for a target patient; determining a risk level for the target patient of developing the clinical condition; and indicating the risk level of the target patient, where the set of patient-related variables consists of a first set of variables when the clinical condition is a mortality condition and a second set of variables when the clinical condition is a morbidity condition. | 03-08-2012 |
| 20120047310 | Crossbar circuitry for applying a pre-selection prior to arbitration between transmission requests and method of operation of such crossbar circuitry - Crossbar circuitry has data input and output paths, and at each intersection between a data input and output path, a crossbar cell is provided. A transmission circuit is responsive to a stored routing value to couple a data input path to a selected data output path. Pre-selection circuitry cooperates with the pre-selection circuits of other crossbar cells on the same data output path to use the bit lines of the data output path to compare quality-of-service values associated with multiple asserted transmission requests and to determine a subset thereof which have a highest value of the quality-of-service values. Arbitration circuitry implements a predetermined priority scheme to choose from that subset of requests and to cause the configuration storage circuit of only one crossbar cell associated with the same data output path to have its routing value programmed to the first value, thereby resolving conflict between multiple asserted transmission requests. | 02-23-2012 |
| 20120046196 | ADRB2 Cancer Markers - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ADRB2 markers for cancer. | 02-23-2012 |
| 20120045487 | MULTIPHASIC MICROFIBERS FOR SPATIALLY GUIDED CELL GROWTH - A multiphasic microfiber for a three-dimensional tissue scaffold and/or cellular support is provided in one aspect that includes at least one biocompatible material. The multiphasic microfiber optionally has a first phase and at least one distinct additional phase and is formed by electrohydrodynamic jetting. Further, such microfibers optionally have one or more biofunctional agents, which may be surface-bound moieties provided in spatial patterns. Multiphasic microfibers formed in accordance with the disclosure may form, in some cases, three-dimensional fiber scaffolds with precisely engineered, micrometer-scaled patterns for cellular contact guidance, which may thus support and/or promote cellular growth, proliferation, differentiation, repair, and/or regeneration for tissue and bioengineering applications. | 02-23-2012 |
| 20120041450 | MINIMAL ACCESS TOOL - A minimal access tool includes a frame arranged to be attached to an arm of a user, a tool shaft having a proximal end and a distal end, where the tool shaft proximal end is connected to the frame. The tool further includes an input joint having a first end connected to the frame and a second end arranged to receive user input, the input joint including a virtual center-of-rotation (VC) mechanism which provides a center of rotation that generally coincides with a wrist joint of the user. An output joint is connected to the tool shaft distal end, where the output joint is coupled to the input joint via a mechanical transmission connected therebetween to correlate motion of the input joint to motion of the output joint. | 02-16-2012 |
| 20120040971 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS - The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasis, by administering a benzodiazepinone and methods of reducing the proliferation of keratinocyte cells by exposing such cells to a benzodiazepinone. | 02-16-2012 |
| 20120038085 | DYNAMIC NANO-INSCRIBING FOR CONTINUOUS AND SEAMLESS METAL AND POLYMER NANOGRATINGS - Nanoscale grating structure can be utilized in many practical applications in optics, flat-panel displays and bio-sensors. A Dynamic Nano-Inscribing (Dynamic Nano-Inscribing) technique is disclosed for directly creating large-area, truly continuous nano-grating patterns in a variety of metal or polymer materials with feature size down to sub-50 nm and at very high speed (10 cm/sec). Dynamic Nano-Inscribing is carried out under either ambient temperature or with a brief heating time on the order of ten microseconds, which minimizes damage on UV or thermo-sensitive functional materials. | 02-16-2012 |
| 20120035244 | PARP1 TARGETED THERAPY - The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to PARP1 proteins and nucleic acids as clinical and research targets for cancer. | 02-09-2012 |
| 20120034252 | COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE - The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications. | 02-09-2012 |
| 20120032346 | ENVIRONMENT-RESISTANT MODULE, MICROPACKAGE AND METHODS OF MANUFACTURING SAME - An environment-resistant module which provides both thermal and vibration isolation for a packaged micromachined or MEMS device is disclosed. A microplatform and a support structure for the microplatform provide the thermal and vibration isolation. The package is both hermetic and vacuum compatible and provides vertical feedthroughs for signal transfer. A micromachined or MEMS device transfer method is also disclosed that can handle a wide variety of individual micromachined or MEMS dies or wafers, in either a hybrid or integrated fashion. The module simultaneously provides both thermal and vibration isolation for the MEMS device using the microplatform and the support structure which may be fabricated from a thin glass wafer that is patterned to create crab-leg shaped suspension tethers or beams. | 02-09-2012 |
| 20120030782 | Compositions and Methods for Generating Transgenic Animals - The present invention provides methods of altering gene expression of embryos to provide compositions and methods for efficient generation of transgenic animals. In particular, the present invention provides compositions and methods for generating germline transgenic animals by direct injection of nucleic acid molecules into animals. | 02-02-2012 |
| 20120027685 | DETERMINING THE CAPABILITY OF A TEST COMPOUND TO AFFECT SOLID TUMOR STEM CELLS - A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumor cells in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis. | 02-02-2012 |
| 20120027058 | PORTABLE, WIRELESS MULTI-CHANNEL IMPEDANCE ANALYZER - An improved portable wireless impedance analyzer is provided. The impedance analyzer is comprised of: a wireless transceiver configured to receive user commands; a direct digital synthesizer operable to generate an injection signal in accordance with the input parameters; and a microcontroller interfaced with the wireless transceiver and the direct digital synthesizer. The microcontroller translates the user commands from the wireless transceiver into one or more input parameters for the direct digital synthesizer and communicates the input parameters to the direct digital synthesizer. | 02-02-2012 |
| 20120015839 | RECURRENT GENE FUSIONS IN CANCER - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for cancer (e.g., prostate cancer). | 01-19-2012 |
| 20120015351 | miRNA Target Prediction - The present invention relates to generation (e.g., synthesis) of proteins. In particular, the present invention provides methods to predict miRNA targets using sequence similarity and thermodynamic stability of miRNA-bridges across both 3′ and 5′ UTR. Such methods find use in research, diagnostic and therapeutic settings (e.g., to discover targets, drugs, diagnostic products, etc.). | 01-19-2012 |
| 20120011422 | MICROPROCESSOR AND METHOD FOR DETECTING FAULTS THEREIN - A method for detecting microprocessor hardware faults includes sending at least one input signal to a logic block within the microprocessor, collecting an output response to the input signal from the logic block, and determining whether the output response matches an expected output response of the logic block. | 01-12-2012 |
| 20120010541 | Pulsed Cavitational Ultrasound Therapy - Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial-temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and/or the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers. | 01-12-2012 |
| 20120010123 | METHODS OF TREATING METABOLIC DISORDERS AND CARDIOVASCULAR DISEASES - A method of treating an LCN13-related condition is provided comprising administering to a patient in need thereof a therapeutically effective amount of a lipocalin or a physiologically active fragment thereof. | 01-12-2012 |
| 20120009582 | DIAGNOSIS AND TREATMENT OF BREAST CANCER - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to compositions and methods for the prediction of a subject's response to cancer therapies. | 01-12-2012 |
| 20120007791 | Antenna Fabrication with Three-Dimensional Contoured Substrates - Disclosed herein is a method of fabricating an antenna in which a flexible stamp is formed from a first wafer, the first wafer transferring a pattern to the flexible stamp, in which an antenna substrate is shaped into a three-dimensional contour with a second mold, in which the flexible stamp is positioned in the second mold to deform the flexible stamp into the three-dimensional contour, and in which a metallic layer on the flexible stamp is cold welded to create a set of antenna traces on the antenna substrate in accordance with the pattern. The antenna traces may then be electroplated. | 01-12-2012 |
| 20120007046 | CARBON NANOTUBE HYBRID PHOTOVOLTAICS - Systems, methods and devices for the efficient photocurrent generation in single- or multi-walled carbon nanotubes, which includes (SWNTs)/poly [3-hexylthiophene-2,5-diyl] (P3HT) hybrid photovoltaics, and exhibit the following features: photocurrent measurement at individual SWNT/P3HT heterojunctions indicate that both semiconducting (s-) and metallic (m-) SWNTs function as excellent hole acceptors; electrical transport and gate voltage dependent photocurrent indicate that P3HT p-dopes both s-SWNT and m-SWNT, and exciton dissociation is driven by a built-in voltage at the heterojunction. Some embodiments include a mm | 01-12-2012 |
| 20120003277 | NANOEMULSION VACCINES - The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides nanoemulsion compositions harboring one or more immunogens within the oil phase of the nanoemulsion and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the invention find use in, among other things, clinical (e.g., therapeutic and preventative medicine (e.g., vaccination)) and research applications. | 01-05-2012 |
| 20120001536 | ULTRABRIGHT FLUORESCENT OLEDS USING TRIPLET SINKS - A first device is provided. The first device further comprises an organic light emitting device. The organic light emitting device further comprises an anode, a cathode, and an emissive layer disposed between the anode and the cathode. The emissive layer further comprises an organic host compound, an organic emitting compound capable of fluorescent emission at room temperature, and an organic dopant compound. The triplet energy of the dopant compound is lower than the triplet energy of the host compound. The dopant compound does not strongly absorb the fluorescent emission of the emitting compound. | 01-05-2012 |
| 20120001155 | FUSING PORPHYRINS WITH POLYCYCLIC AROMATIC HYDROCARBONS AND HETEROCYCLES FOR OPTOELECTRONIC APPLICATIONS - A compound that can be used as a donor material in organic photovoltaic devices comprising a non-activated porphyrin fused with one or more non-activated polycyclic aromatic rings or one or more non-activated, heterocyclic rings can be obtained by a thermal fusion process. By heating the reaction mixture of non-activated porphyrins with non-activated polycyclic aromatic rings or heterocyclic rings to a fusion temperature and holding for a predetermined time, fusion of one or more polycyclic rings or heterocyclic rings to the non-activated porphyrin core in meso,β fashion is achieved, resulting in hybrid structures containing a distorted porphyrin ring with annulated aromatic rings. The porphyrin core can be olygoporphyrins. | 01-05-2012 |
| 20120001146 | NANOSCALE METAL OXIDE RESISTIVE SWITCHING ELEMENT - A non-volatile memory device structure. The non-volatile memory device structure comprises a first electrode formed from a first metal material, a resistive switching element overlying the first electrode. The resistive switching element comprises a metal oxide material characterized by one or more oxygen deficient sites. The device includes a second electrode overlying the resistive switching layer, the second electrode being formed from a second metal material. The second electrode is made from a noble metal. The one or more oxygen deficient sites are caused to migrate from one of the first electrode or the second electrode towards the other electrode upon a voltage applied to the first electrode or the second electrode. The device can have a continuous change in resistance upon applying a continuous voltage ramp, suitable for an analog device. Alternatively, the device can have a sharp change in resistance upon applying the continuous voltage ramp, suitable for a digital device. | 01-05-2012 |
| 20120000853 | SUPERHYDROPHILIC AND OLEOPHOBIC POROUS MATERIALS AND METHODS FOR MAKING AND USING THE SAME - The present disclosure provides a porous material having a surface that is concurrently both superhydrophilic (having a first apparent advancing dynamic contact angle of less than or equal to about 5° for water) and oleophobic (having a second apparent advancing dynamic contact angle of greater than or equal to about 90°) or superoleophobic (a second apparent advancing dynamic contact angle of greater than or equal to about 150° for oil). Such materials can be used in a separator device to separate a liquid-liquid mixture of immiscible components (e.g., oil and water) or miscible components (e.g., alcohols). Separation apparatus incorporating such materials and methods of making and using these materials are also provided. | 01-05-2012 |
| 20110317470 | RECTIFICATION ELEMENT AND METHOD FOR RESISTIVE SWITCHING FOR NON VOLATILE MEMORY DEVICE - A method of suppressing propagation of leakage current in an array of switching devices. The method includes providing a dielectric breakdown element integrally and serially connected to a switching element within each of the switching device. A read voltage (for example) is applied to a selected cell. The propagation of leakage current is suppressed by each of the dielectric breakdown element in unselected cells in the array. The read voltage is sufficient to cause breakdown in the selected cells but insufficient to cause breakdown in the serially connected, unselected cells in a specific embodiment. Methods to fabricate of such devices and to program, to erase and to read the device are provided. | 12-29-2011 |
| 20110311746 | SCAFFOLDS AND METHODS OF FORMING THE SAME - Various embodiments of scaffolds are disclosed herein. In one embodiment, the scaffold includes a tubular polymeric structure, and a controlled gradient of solid-walled microtubules oriented radially or axially in the tubular polymeric structure. In another embodiment, the scaffold includes a nano-fibrous tubular polymeric structure, and an oriented and interconnected microtubular porous network formed in the nano-fibrous tubular polymeric structure. In still another embodiment, a composite scaffold is formed including a polymeric structure having an inner wall and an outer wall, and at least one electrospun layer positioned along at least one of the inner wall, or the outer wall, or in a middle of the porous polymeric structure. | 12-22-2011 |
| 20110308077 | FIBER-BASED ELECTRIC DEVICE - A method of manufacturing a fiber-based electric apparatus includes providing an elongate, flexible fiber core and layering an electric device on the fiber core. | 12-22-2011 |
| 20110307426 | Personalized Health Risk Assessment For Critical Care - A method for providing a personalized health risk of a patient includes receiving training data corresponding to a plurality of patients and target data corresponding to a target patient; generating model data based on the training data according to an anomaly detection method; either determining whether the target data is anomalous with respect to the training data, or determining the extent to which the target data is anomalous with respect to the training data; and either indicating whether the target patient is at risk of the adverse outcome, or indicating the extent to which the target patient is at risk of the adverse outcome. | 12-15-2011 |
| 20110307139 | COMPUTATIONALLY EFFICIENT INTERSECTION COLLISION AVOIDANCE SYSTEM - The present invention discloses a back-propagating intersection collision avoidance (ICA) system for preventing two or more vehicles from colliding at an intersection. The ICA system can calculate predicted positions of the two or more vehicles in the near future, and both the current and future positions can be broadcast to surrounding vehicles using vehicle-to-vehicle communication. For each vehicle, a set of states, for example position, speed, acceleration, and the like, where a collision is imminent can be identified using state information for a local vehicle, a remote vehicle, and a known collision zone for the intersection. If the current states of the vehicles are determined to be in danger of entering the collision zone, the ICA system can control the vehicles to perform evasive driving maneuvers and/or alert the drivers. | 12-15-2011 |
| 20110303824 | Apparatus for Sub-Wavelength Near-Field Focusing of Electromagnetic Waves - Planar sub-wavelength structures provide superlensing, i.e., electromagnetic focusing beyond the diffraction limit. The planar structures use diffraction to force the input field to converge to a spot on the focal plane. The sub-wavelength patterned structures manipulate the output wave in such a manner as to form a sub-wavelength focus in the near field. In some examples, the sub-wavelength structures may be linear grating-like structures that can focus electromagnetic radiation to lines of arbitrarily small sub-wavelength dimension, or two dimensional grating-like structures and Bessel (azimuthally symmetric) structures that can focus to spots of arbitrarily small sub-wavelength dimensions. The particular pattern for the sub-wavelength structures may be derived from the desired focus. Some examples describe sub-wavelength structures that have been implemented to focus microwave radiation to sub-wavelength dimensions in the near field. | 12-15-2011 |
| 20110301535 | MICROFLUIDIC CONTROL SYSTEMS - The present invention relates to microfluidic devices. In particular, the present invention relates to microfluidic devices for performing spatio-temporal operations and applications thereof. | 12-08-2011 |
| 20110300306 | COAXIAL LASER ASSISTED COLD SPRAY NOZZLE - A cold spray nozzle assembly for applying a coating of particles to a substrate includes a nozzle defining an inner passage with a nozzle exit. The nozzle assembly also includes a particle supply member in communication with the inner passage. The particle supply member supplies the particles to flow and accelerate through the inner passage and out of the nozzle via the nozzle exit toward the substrate to be coated thereon. Furthermore, the nozzle assembly includes a laser that emits a laser beam that is transmitted through the inner passage. The laser heats at least one of the particles and the substrate to promote coating of the substrate with the particles. | 12-08-2011 |
| 20110291079 | SURFACE PLASMON-MEDIATED ENERGY TRANSFER OF ELECTRICALLY-PUMPED EXCITONS - An electrically pumped light emitting device emits a light when powered by a power source. The light emitting device includes a first electrode, a second electrode including an outer surface, and at least one active organic semiconductor disposed between the first and second electrodes. The device also includes a dye adjacent the outer surface of the second electrode such that the second electrode is disposed between the dye and the active organic semiconductor. A voltage applied by the power source across the first and second electrodes causes energy to couple from decaying dipoles into surface plasmon polariton modes, which then evanescently couple to the dye to cause the light to be emitted. | 12-01-2011 |
| 20110289632 | METHYLKETONE SYNTHASE, PRODUCTION OF METHYLKETONES IN PLANTS AND BACTERIA - Isolated genes and amino acid sequences encode methylketone synthase 2 (MKS2) enzymes from tomato plants, including, ShMKS2 and SlMKS2. When expressed recombinantly in bacteria and other host cells, the MKS2 enzymes produce methylketones of various carbon chain lengths ranging from C | 11-24-2011 |
| 20110285518 | METHOD FOR DETECTING RUMBLE STRIPS ON ROADWAYS - A method and system for detecting the existence of rumble strips on a roadway by a vehicle. Wheel speed data is obtained from a wheel speed sensor, and frequency-based analysis is then performed on the wheel speed data. The presence of a rumble strip can then be detected based on the outcome of the frequency-based analysis. The wheel speed data can be modified before conversion to the frequency domain to reduce wheel-induced cyclic variations in wheel speed. The frequency-based analysis can use an FFT and a peak detection method that analyzes one or more peaks in the FFT data to determine if any are indicative of the presence of a rumble strip. The method can be carried out automatically in real time and used to alert the driver of the detection of the rumble strip. | 11-24-2011 |
| 20110280964 | Composition And Method of Treating Hearing Loss - A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal. | 11-17-2011 |
| 20110280911 | CANCER VACCINE COMPOSITIONS AND METHODS OF USING THE SAME - The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications. | 11-17-2011 |
| 20110268731 | METHODS OF TREATING AUTOIMMUNE DISORDERS AND/OR INFLAMMATORY DISORDERS - The present invention relates to dendrimer compositions configured for treating inflammatory disorders and autoimmune disorders, and related methods of synthesis. Specifically, the present invention relates to methods for treating rheumatoid arthritis with PAMAM dendrimers having functional ligands configured for treating rheumatoid arthritis (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents) (e.g., methotrexate). | 11-03-2011 |
| 20110264937 | COMPUTER ENERGY CONSERVATION WITH A SCALABLE PSU CONFIGURATION - A power management method for use by a blade server or other networked computer having a CPU, memory, network interface, and timer. The method includes monitoring processes in the computer, determining that the computer has become idle, and switching the CPU and memory from an active state to a low power state while maintaining the network interface and timer in an active state. Power management for multicore processors is also provided. A power supply system can be used for providing shared power to groups of the networked computers that each have a similar active power demand. Each PSU in the power supply system is capable of supplying the active power demand at an efficiency greater than a preselected desired minimum efficiency. Changes in power requirements resulting from a computer switching between low power and active states can be accommodated by switching a single PSU into or out of the system. | 10-27-2011 |
| 20110257955 | Gate-Level Logic Simulator Using Multiple Processor Architectures - Techniques for simulating operation of a connectivity level description of an integrated circuit design are provided, for example, to simulate logic elements expressed through a netlist description. The techniques utilize a host processor selectively partitioning and optimizing the descriptions of the integrated circuit design for efficient simulation on a parallel processor, more particularly a SIMD processor. The description may be segmented into cluster groups, for example macro-gates, formed of logic elements, where the cluster groups are sized for parallel simulation on the parallel processor. Simulation may occur in an oblivious as well as event-driven manner, depending on the implementation. | 10-20-2011 |
| 20110257648 | ABLATION CATHETERS - The present invention relates generally to multifunctional catheters for performing ablation procedures, and more particularly to ablation catheters utilized in the treatment of atrial fibrillation and other cardiac disorders. The present invention eliminates many of the problems associated with previous ablation catheters by providing an ablation treatment not dependent upon continuous lesions. | 10-20-2011 |
| 20110257504 | BIOLOGICALLY INTEGRATED ELECTRODE DEVICES - Bioelectrodes having enhanced biocompatible and biomimetic features are provided. Methods of making and using the bioelectrodes are further provided. A biologically integrated bioelectrode device and method for detecting electronic signals using a bioelectrode comprising a first electrically conductive substrate and a biological component. The bioelectrode also comprises a conductive polymer electrically coupling the first electrically conductive substrate and the biological component to define a bioelectrode. The bioelectrode can transmit or receive an electrical signal between the electrically conductive substrate and the biological component and conductive polymer. | 10-20-2011 |
| 20110256172 | EPITOPE-TARGETED ANTHRAX VACCINE - Anthrax vaccine compositions comprise a segment of a PA toxin protein that stimulates a B cell immune response specific for a defined epitope on the protective antigen of | 10-20-2011 |
| 20110256121 | METHODS AND KITS FOR DIAGNOSING OR MONITORING AUTOIMMUNE AND CHRONIC INFLAMMATORY DISEASES - The present invention relates to compositions and methods for diagnosing, monitoring and/or treating disease (e.g., autoimmune or chronic inflammatory disease, heart disease and/or stroke). In particular, the present invention provides methods for diagnosing, monitoring and treating disease based upon detecting or altering (e.g., altering expression or methylation status of) disease proteins (e.g., CD70, CD40L, and/or KIR). The present invention also provides kits for detecting methylation status of disease proteins (e.g., CD70, CD40L, and/or KIR) and for diagnosing, monitoring and/or treating diseases (e.g., autoimmune or chronic inflammatory disease, heart disease and/or stroke). | 10-20-2011 |
| 20110255380 | High Resolution Time Measurement in a FPGA - Various techniques are described for high resolution time measurement using a programmable device, such as an FPGA. The timing may be triggered by any event, depending on the applications of use. Once triggering has occurred, a START pulse begins propagating through the FPGA. The pulse is able to propagate through the FPGA in a staggered manner traversing multiple FPGA columns to maximize the amount of time delay that may be achieved while minimizing the overall array size, and thus minimizing the resource utilization, of the FPGA. The FPGA timing delay is calibrated by measuring for the linear and non-linear differences in delay time of each unit circuit forming the staggered delay line path for the timing circuit. The FPGA is able to achieve nanosecond and sub-nanosecond time resolutions and thus may be used in applications such as various time of flight systems. | 10-20-2011 |
| 20110253992 | ORGANIC PHOTOSENSITIVE DEVICES USING SUBPHTHALOCYANINE COMPOUNDS - An organic photosensitive optoelectronic device includes an anode, a cathode, and a donor-acceptor heterojunction between the anode and the cathode, the heterojunction including a donor-like material and an acceptor-like material, wherein at least one of the donor-like material and the acceptor-like material includes a subphthalocyanine, a subporphyrin, and/or a subporphyrazine compound, wherein the subporphyrin or subporphyrazine compound includes boron. | 10-20-2011 |
| 20110253200 | REFLECTIVE TANDEM SOLAR CELL - A novel solar cell architecture consisting of multiple fiber-based photovoltaic (PV) cells. Each PV fiber element is designed to maximize the power conversion efficiency within a narrow band of the incident solar spectrum, while reflecting other spectral components through the use of optical microcavity effects and distributed Bragg reflector (DBR) coatings. Combining PV fibers with complementary absorption and reflection characteristics into volume-filling arrays produces an array of spectrally tuned solar cells with an effective dispersion element intrinsic to the architecture, resulting in high external quantum efficiency over the visible spectrum. | 10-20-2011 |
| 20110251357 | ULTRAVIOLET TRANSMISSIVE POLYHEDRAL SILSESQUIOXANE POLYMERS - Inorganic/organic hybrid polymers containing silsesquioxane cages are robust and exhibit desirable physical properties such as strength, hardness, and optical transparency at infrared and ultraviolet wavelengths. The polymers are prepared by polymerizing functionalized polyhedral silsesquioxane monomers such as polyhedral silsesquioxanes bearing two complementarily reactive functional groups bonded to cage silicon atoms by means of spacer moieties. The spacer moieties allow for steric mobility and more complete cure than polyhedral silsesquioxanes bearing reactive functional groups bound directly to cage silicon atoms. | 10-13-2011 |
| 20110251252 | BIOMARKERS FOR MDM2 INHIBITORS FOR USE IN TREATING DISEASE - Provided herein are methods for selecting and treating a subject with leukemia, wherein the subject is selected for treatment and is treated with an MDM2 inhibitor because said subject's cells contain an FLT3-ITD mutation. | 10-13-2011 |
| 20110251216 | COMPOSITIONS AND METHODS FOR INHIBITING EZH2 - The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in cancer (e.g., prostate cancer, breast cancer, other solid tumors, multiple myeloma). | 10-13-2011 |
| 20110251200 | ARYL GUANIDINE F1F0-ATPASE INHIBITORS AND RELATED METHODS - The invention provides to a family of aryl guanidine-based F | 10-13-2011 |
| 20110250589 | BIOMARKERS FOR LUNG DISEASE MONITORING - The present invention pertains to the monitoring and treatment of lung transplant recipients. In particular, the invention pertains to the use of biomarkers to predict or detect post-lung transplantation complications (e.g., organ rejection, acute organ rejection, organ injury, bronchiolitis obliterans, bronchiolitis obliterans syndrome, organizing pneumonia), fibroproliferative repair responses, interstitial lung diseases (e.g., idiopathic pulmonary fibrosis and other fibrotic lung diseases), and other immune-mediated lung diseases (e.g., graft versus host disease, scleroderma). | 10-13-2011 |
| 20110250427 | ULTRASTRONG AND STIFF LAYERED POLYMER NANOCOMPOSITES AND HIERARCHICAL LAMINATE MATERIALS THEREOF - A stiff layered polymer nanocomposite comprising a substrate adapted to receive a plurality of alternating layers of a first material and a second material; wherein the first material and second material are a polyelectrolyte, an organic polymer or an inorganic colloid and said first material and said second material have a chemical affinity for each other, said plurality of layers crosslinked using a chemical or physical crosslinking agent. Thin films that are consolidated and optionally crosslinked can be manufactured into hierarchical laminates with rigid and stress resistant properties. | 10-13-2011 |
| 20110246843 | ERROR DETECTION IN PRECHARGED LOGIC - An integrated circuit is provided with domino logic including a speculative node and a checker node. Precharged circuitry precharges both the speculative node and the checker node. Logic circuitry provides a discharge path for the speculative node and the checker node in dependence upon input signal values. Evaluation control circuitry first couples the speculative node to the logic circuitry and then subsequently couples the checker node to the logic circuitry such that these can be discharged if the input signals to the logic circuitry have appropriate values. Error detection circuitry detects an error when the speculative node and the checker node are not one of both discharged or both undischarged. | 10-06-2011 |
| 20110245238 | Novel Soluble 1,4 Benzodiazepine Compounds and Stable Salts Thereof - The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like. | 10-06-2011 |
| 20110241046 | Light Emitting Device Having Peripheral Emissive Region - Light emitting devices are provided that include one or more OLEDs disposed only on a peripheral region of the substrate. An OLED may be disposed only on a peripheral region of a substantially transparent substrate and configured to emit light into the substrate. Another surface of the substrate may be roughened or include other features to outcouple light from the substrate. The edges of the substrate may be beveled and/or reflective. The area of the OLED(s) may be relatively small compared to the substrate surface area through which light is emitted from the device. One or more OLEDs also or alternatively may be disposed on an edge of the substrate about perpendicular to the surface of the substrate through which light is emitted, such that they emit light into the substrate. A mode expanding region may be included between each such OLED and the substrate. | 10-06-2011 |
| 20110237976 | BIOPSY DEVICE HAVING HEMOSTATIC CONTROL - A biopsy device assembly performs a biopsy of an anatomical tissue of a patient. The biopsy device assembly includes a housing and a biopsy device that extends out of the housing and that collects and cuts anatomical tissue from the patient. The biopsy device assembly further includes a hemostatic agent removably housed in the biopsy device. Moreover, the assembly includes an actuator assembly that moves the biopsy device relative to the housing from a first position to an extended position such that the biopsy device collects and cuts the anatomical tissue from the patient. The actuator assembly also retracts the biopsy device relative to the housing toward a retracted position. Furthermore, the assembly includes an ejection device that ejects the hemostatic agent from the biopsy device as the actuator assembly retracts the biopsy device toward the retracted position. | 09-29-2011 |
| 20110237461 | USING PHAGE EPITOPES TO PROFILE THE IMMUNE RESPONSE - The present disclosure provides compositions and methods for using one or more polypeptide probes to profile an immune response. The polypeptide probe can be used to detect one or more antibodies from a sample. Furthermore, the present disclosure provides methods and compositions for characterizing a cancer based on the detection of one or more antibodies, such as autoantibodies. | 09-29-2011 |
| 20110236993 | PANCREATIC CANCER MARKERS - The present invention relates to pancreatic cancer markers. In particular, the present invention provides methods and compositions for the identification of protein glycosylation patterns associated with pancreatic cancer. | 09-29-2011 |
| 20110229512 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING URINARY TRACT INFECTIONS - The present invention relates to methods and compositions for treating urinary tract infections. In particular, the present invention relates to vaccines and immune modulators for treating urinary tract infections. | 09-22-2011 |
| 20110215854 | Clock Distribution Network Architecture with Clock Skew Management - Disclosed herein is a digital system that includes a distribution network having a path to carry a reference clock and an adjustable delay element disposed along the path, and first and second clock domains coupled to the distribution network to receive the reference clock and configured to be driven by respective clock waveforms, each of which has a frequency in common with the reference clock. The digital system further includes a phase detector coupled to the first and second clock domains to generate a phase difference signal based on the clock waveforms, and a control circuit coupled to the phase detector and configured to adjust the adjustable delay element based on the phase difference signal. | 09-08-2011 |
| 20110214014 | MICROPROCESSOR AND METHOD FOR DETECTING FAULTS THEREIN - A method for detecting microprocessor hardware faults includes sending at least one input signal to a logic block within the microprocessor, collecting an output response to the input signal from the logic block, and determining whether the output response matches an expected output response of the logic block. | 09-01-2011 |
| 20110210903 | FREQUENCY-SELECTIVE SURFACE (FSS) STRUCTURES - Frequency-selective surface (FSS) structures that may be used in a variety of different filtering capacities and applications. According to exemplary embodiments, there is disclosed: 1) a one-sided FSS structure that has a conductive grid and conductive loops located on the same side of a thin substrate and exhibits a single pole frequency response; 2) a multiple layer FSS structure that has several one-sided FSS layers and exhibits a multiple pole frequency response; 3) a loop/loop tunable FSS structure where the frequency response can be adjusted or tuned with a bias network; 4) a grid/grid tunable FSS structure where the frequency response can be adjusted or tuned without the use of bias network; and 5) an antenna arrangement that has a FSS structure placed over top of antenna array so that the need for separate components, like bulky filters in a transceiver chain, can be eliminated. | 09-01-2011 |
| 20110209110 | Tensor Transmission-Line Metamaterials - Tensor transmission-line metamaterial unit cells are formed that allow the creation of any number of optic/electromagnetic devices. A desired electromagnetic distribution of the device is determined, from which effective material parameters capable of creating that desired distribution are obtained, for example, through a transformation optics/electromagnetics process. These effective material parameters are then linked to lumped or distributed circuit networks that achieve the desired distribution. | 08-25-2011 |
| 20110207675 | GENE FUSION TARGETED THERAPY - The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to recurrent gene fusions as clinical targets for prostate cancer. | 08-25-2011 |
| 20110207198 | COMPOSITIONS AND METHODS FOR INHIBITING MMSET - The present invention relates to agents that find use in the treatment, management, and/or study of cancer. In particular, the present invention relates to agents (e.g., small molecules, nucleic acids) that affect MMSET expression or activity. | 08-25-2011 |
| 20110206697 | SPINK1 TARGETED THERAPY - The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to SPINK1 as a clinical target for prostate cancer. | 08-25-2011 |
| 20110204785 | CROSSED FIELD DEVICE - A crossed field device, such as a magnetron or crossed field amplifier, that includes a cathode, an anode, one or more magnetic elements, and one or more extraction elements. In one embodiment, the crossed field device includes an annular cathode and anode that are axially spaced from one another such that the device produces an axial electric (E) field and a radial magnetic (B) field. In another embodiment, the crossed field device includes an oval-shaped cathode and anode that are radially spaced from one another such that the device produces a radial electric (E) field and an axial magnetic (B) field. The crossed field device may produce electromagnetic (EM) emissions having a frequency ranging from megahertz (MHz) to terahertz (THz), and may be used in one of a number of different applications. | 08-25-2011 |
| 20110202786 | Stalling synchronisation circuits in response to a late data signal - A data processing circuitry for processing data is disclosed. The data processing circuitry comprises: a plurality of synchronisation circuits for capturing and transmitting the data in response to a clock signal and a plurality of combinational circuits arranged between the synchronisation circuits for processing the data, the plurality of synchronisation circuits being arranged in at least two groups; an error detecting circuit for determining if the data input to one of the plurality of synchronisation circuits is stable during a predetermined time and for signalling an error if the data input is not stable, the predetermined time being less than a half cycle of the clock signal; control circuitry responsive to said error detecting circuit signalling said error to transmit a control signal to at least one of said groups of synchronisation circuits that contains a subsequent synchronisation circuit that said synchronisation circuit with said unstable input is configured to transmit said data to; each of said group of synchronisation circuits being configured to respond to receipt of said control signal to stall for a clock cycle and to transmit a stall signal to at least one further group of synchronisation circuits that said group of synchronisation circuits is configured to transmit data to or receive data from; each of said group of synchronisation circuits being configured to respond to receipt of said stall signal provided they have not stalled in a preceding clock cycle to stall for a clock cycle and to transmit a stall signal to said at least one further group of synchronisation circuits. | 08-18-2011 |
| 20110196280 | SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF - The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action. | 08-11-2011 |
| 20110196259 | In-Situ Tissue Analysis Device and Method - A sensor is mounted to a needle at a location proximate to a tip of the needle. The sensor senses tissue density of tissue in contact with the tip as the needle passes through the tissue. Further, the sensor detects a change in tissue density as the tip passes from one tissue to a target tissue. | 08-11-2011 |
| 20110195959 | Compositions And Methods Relating To Novel Compounds And Targets Thereof - The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine compounds, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, vascular abnormalities, and the like. | 08-11-2011 |
| 20110193633 | BIOAMPLIFIER FOR NEURAL INTERFACES - A bioamplifier that includes a high pass filter, open-loop amplifier, and low pass filter in an area efficient design that can be used in implantable neural interfaces. The high pass filter can be implemented by using a switch-capacitance resistor coupled with parasitic capacitance of the electrode. The amplifier can be chopper stabilized and can include a high gain, current-ratio first stage followed by one or more dimension-ratio stages. The low pass filter utilizes the output impedance of the open-loop amplifier to form an embedded g | 08-11-2011 |
| 20110189716 | METHOD FOR ANALYZING COLLAGENOUS TISSUES FOR THE DETECTION AND DIAGNOSIS OF BONE DISEASE - Methods and systems for diagnosing a bone disease related to collagen pathology in a subject are provided. These include providing a bone sample from the subject and determining a quantitative collagen morphology value of the bone sample. A reference value is provided from a non-affected control subject where the reference value is a quantitative collagen morphology value from the same type of bone sample obtained from a population of non-affected control subjects. The quantitative collagen morphology value of the subject's bone sample is compared to the reference value. If the collagen morphology value is altered versus the reference value, the subject is diagnosed as having a collagen related bone disease. The collagen morphology value can include mean fibril spacings and distributions of the fibril spacings taken from a subject's bone sample. | 08-04-2011 |
| 20110184313 | Cauterization Device and Method of Cauterizing - A medical device such as a biopsy needle or probe has an integrated piezoelectric transducer. A power source is electrically coupled to the piezoelectric transducer. The power source is configured to generate a signal that causes the piezoelectric transducer to generate heat for cauterizing tissue. A signal analyzer receives a signal from the piezoelectric transducer, or from a sensor integrated into the biopsy needle or probe, to determine the extent of the cauterization. | 07-28-2011 |
| 20110184033 | Selective Ligands for the Dopamine 3 (D3) Receptor and Methods of using the Same - Potent and selective ligands for the dopamine 3 (D | 07-28-2011 |
| 20110183868 | SOLUTION MICROARRAYS AND USES THEREOF - The present invention relates to solution microarrays. In particular, the present invention relates to an aqueous 2-phase system for solution microarrays and uses thereof. Additional embodiments are described herein. | 07-28-2011 |
| 20110183866 | COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER - The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer. | 07-28-2011 |
| 20110180305 | ELECTRODE ARRAY AND METHOD OF FABRICATION - An electrode array, having application as a cochlear implant, includes a tube formed of Parylene defining a hollow channel. A substrate formed primarily of Parylene is supported by the tube. In turn, a plurality of metallic electrodes and feed lines are supported by the substrate. Numerous voids are defined by the tube which opens into the hollow channel. The size and spacing of the voids regulate stiffness and curl of the tube to provide excellent fit within the cochlea. | 07-28-2011 |
| 20110178038 | Indole Antiviral Compositions And Methods - The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases. | 07-21-2011 |
| 20110172981 | HIGH THROUGHPUT ENSEMBLE-BASED DOCKING AND ELUCIDATION OF THREE-DIMENSIONAL STRUCTURAL CONFIRMATIONS OF FLEXIBLE BIOMOLECULAR TARGETS - Methods for generating putative ligand structures capable of altering the activity of a target effector molecule comprise: constructing an elongated monomer of the target effector molecule; constructing a three dimensional model of the target effector molecule under the influence of elongation using empirical three dimensional data, the model including a conformation revealing the binding portion of the target effector molecule to a putative ligand structure; generating a plurality of computational models of the target effector molecule; filtering the plurality of computational models against the three dimensional model created experimentally using a reiterative simulation analysis algorithm operable to identify and select a plurality of computational models having a root-mean square deviation below a predetermined threshold when compared to the three dimensional model of the target effector molecule; screening a plurality of ligands to rank the binding strength of each ligand with the plurality of computational models selected and selecting one or more ligands based on the ranking. | 07-14-2011 |
| 20110168984 | VISIBLE/NEAR-INFRARED PORPHYRIN-TAPE/C60 ORGANICPHOTODETECTORS - Porphyrin compounds are provided. The compounds may further comprise a fused polycyclic aromatic hydrocarbon or a fused heterocyclic aromatic. Fused polycyclic aromatic hydrocarbon s and fused heterocyclic aromatics may extend and broaden absorption, and modify the solubility, crystallinity, and film-forming properties of the porphyrin compounds. Additionally, devices comprising porphyrin compounds are also provided. The porphyrin compounds may be used in a donor/acceptor configuration with compounds, such as C | 07-14-2011 |
| 20110166144 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same - The present disclosure is directed to pyrimidotriazinediones and pyrimidopyrimidinediones having a formula (I), (II), or (III), or a mixture or pharmaceutically acceptable salt or hydrate thereof, and to methods of treating cancer comprising administering the same. | 07-07-2011 |
| 20110159028 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING URINARY TRACT INFECTIONS - The present invention relates to methods and compositions for treating urinary tract infections. In particular, the present invention relates to vaccines and immune modulators for treating urinary tract infections. | 06-30-2011 |
| 20110158982 | COMPOSITIONS AND METHODS FOR INHIBITING MAdCAM - The present invention relates to therapeutic targets for multiple sclerosis and neuroinflammatory diseases and injuries. In particular, the present invention relates to targeting MAdCAM in the treatment of such disorders. | 06-30-2011 |
| 20110155928 | INTEGRATIVE AND REAL-TIME RADIATION MEASUREMENT METHODS AND SYSTEMS - A method of determining the radiation type and energy distribution of a radiation source that outputs radiation. The method including providing a plurality of detector materials and exposing the plurality of detector materials to the radiation. Each of the plurality of detector materials stores a signal in response to being exposed to the radiation. The signals are representative of the radiation. The plurality of detector materials is stimulated to output the signals as measured signals. These measured signals are used to determine the radiation type and energy distribution of the radiation. | 06-30-2011 |
| 20110151497 | METABOLOMIC PROFILING OF PROSTATE CANCER - The present invention relates to cancer markers. In particular, the present invention provides metabolites and panels of metabolites that are differentially present in cancer (e.g., prostate or breast cancer). | 06-23-2011 |
| 20110144229 | BIOCOMPATIBLE COATINGS, AND METHODS OF MAKING AND USING THE SAME - Disclosed herein are biocompatible coatings for a substrate, the biocompatible coating including at least one polyanionic/polycationic bilayer including at least one nitric oxide generating moiety, wherein the polyanionic/polycationic bilayer has a layer of a polycationic polymeric material; and a layer of polyanionic material capable of non-covalently bonding to the polycationic polymeric material. Devices incorporating such coatings, and methods of making and using such coatings are also disclosed herein. | 06-16-2011 |
| 20110143430 | HEMATOPOIETIC STEM CELL IDENTIFICATION AND ISOLATION - The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150 | 06-16-2011 |
| 20110142816 | THERMOSTABILIZATION OF PROTEINS - Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal under-going a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition. | 06-16-2011 |
| 20110140577 | INCREASED FREQUENCY POWER GENERATION USING LOW-FREQUENCY AMBIENT VIBRATIONS - An increased frequency power generator that includes a pair of transducers located on opposite sides of a suspended inertial mass. Magnetic attraction is used to couple the mass to each of the two transducers in alternating fashion in response to vibration and other movement externally imparted on the generator. Each transducer includes a suspended magnetic element that couples and decouples to the inertial mass as it reciprocates in the housing due to the applied external moving force. As the inertial mass decouples from one transducer on its way to magnetically connecting to the other transducer, the decoupled suspended magnetic element oscillates at a frequency greater than the imparting force, thereby generating electrical power. | 06-16-2011 |
| 20110138098 | Crossbar circuitry for applying an adaptive priority scheme and method of operation of such crossbar circuitry - Crossbar circuitry has an array of data input and output paths where the data output paths are transverse to the data input paths. At each intersection between a data input path and a data output path, a crossbar cell is provided which includes a configuration storage circuit programmable to store a routing value, a transmission circuit, and an arbitration circuit. In a transmission mode of operation, the transmission circuit is responsive to the routing value being a first value, indicating that the data input path should be coupled to the data output path, to detect the data input along the data input path, and to output an indication of that data on the data output path at the associated intersection. In an arbitration mode of operation, the arbitration circuitry is operable to selectively modify the voltage on said plurality of bit lines in order to apply an adaptive priority scheme. | 06-09-2011 |
| 20110128010 | MICRODISCHARGE-BASED PRESSURE SENSOR AND METHOD - A microdischarge-based pressure sensor that includes an anode, two cathodes, a drive circuit connected to the electrodes, and a measurement circuit that permits sensing of transient current pulses flowing through at least one of the electrodes. One of the cathodes is interposed between the anode and other cathode, and it includes a central opening which permits a microdischarge to occur between the anode and each cathode in response to applied voltage pulses from the drive circuit. Changes in relative current between the two cathodes are indicative of changes in ambient pressure in the microdischarge chamber. In other embodiments, a sealed chamber can be used with one of the electrodes acting as a diaphragm which deflects based on external pressure and changes its inter-electrode spacing, thereby altering the relative cathode currents. | 06-02-2011 |
| 20110125029 | Targeted Dual-Axes Confocal Imaging Apparatus with Vertical Scanning Capabilities - An optical device is described that may be used as a microscope system for real-time, three-dimensional optical imaging. The device includes a miniature, fiber optic, intra-vital probe microscope that uses a dual-axes confocal architecture to allow for vertical scanning perpendicular to a surface of the sample (e.g., a tissue surface). The optical device can use off-axis illumination and collection of light to achieve sub-cellular resolution with deep tissue penetration. The optical device may be used as part of an integrated molecular imaging strategy using fluorescence-labeled peptides to detect cell surface targets that are up-regulated by the epithelium and/or endothelium of colon and breast tumors in small animal models of cancer. | 05-26-2011 |
| 20110123441 | NOVEL GREB1A MONOCLONAL ANTIBODY - The generation and validation of a novel monoclonal GREB1 antibody (GREB1ab). Methods for the prognosis, diagnosis, assessment of disease progression, severity and outcome utilize GREB1 molecules as biomarkers. The GREB1 antibody is also a useful tool for investigations focused on the expression, distribution and function of GREB1 in normal and cancer tissues. | 05-26-2011 |
| 20110121239 | CATALYTIC REFORMING METHODS - A catalytic reforming method is disclosed herein. The method includes sequentially supplying a plurality of feedstocks of variable compositions to a reformer. The method further includes adding a respective predetermined co-reactant to each of the plurality of feedstocks to obtain a substantially constant output from the reformer for the plurality of feedstocks. The respective predetermined co-reactant is based on a C/H/O atomic composition for a respective one of the plurality of feedstocks and a predetermined C/H/O atomic composition for the substantially constant output. | 05-26-2011 |
| 20110118105 | Use of microwave energy to remove contaminating deposits from a catalyst - The disclosure relates to apparatus, systems, and methods (a) for performing catalytic reactions using a fixed-bed catalyst (e.g., packed particulate bed or catalyst supported on a monolithic substrate) and (b) for regenerating the catalytic activity of the catalyst. An autothermal reformation (ATR) reaction system is described for illustrative purposes, although the apparatus, systems, and methods can be applied more generally to other catalytic cracking/reformation reaction systems and other catalytic reaction systems, in particular reaction systems in which carbon-based and/or sulfur-based catalyst contaminants are produced during system operation. | 05-19-2011 |
| 20110117092 | COMPOSITIONS AND METHODS FOR INHIBITING G-CSFR - The present invention relates to therapeutic targets for multiple sclerosis and other inflammatory and neurological diseases. In particular, the present invention relates to altering G-CSF/G-CSFR signaling in the treatment of such disorders. | 05-19-2011 |
| 20110112052 | SPIRO-OXINDOLE MDM2 ANTAGONISTS - Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases. | 05-12-2011 |
| 20110108181 | METHOD AND SYSTEM FOR ONLINE QUALITY MONITORING AND CONTROL OF A VIBRATION WELDING PROCESS - A method for monitoring and controlling a vibration welding system includes collecting sensory data during formation of a welded joint using sensors positioned with respect to welding interfaces of a work piece. A host machine extracts a feature set from a welding signature collectively defined by the sensory data, compares and correlates the feature set with validated information in a library, and executes a control action(s) when the present feature set insufficiently matches the information. A welding system includes a sonotrode, sensors, and the host machine. The host machine is configured to execute the method noted above. | 05-12-2011 |
| 20110105477 | COMPOSITIONS AND METHODS RELATING TO HIV PROTEASE INHIBITION - The present invention relates to HIV protease, and methods for inhibiting the function of HIV protease. In particular, present invention provides compounds that inhibit or block the biological activity of HIVp, thereby causing the replication of the HIV virus to be inhibited or to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS. The compounds and formulations also find use in diagnostic and research settings. | 05-05-2011 |
| 20110104680 | RECURRENT GENE FUSIONS IN LUNG CANCER - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for lung cancer. | 05-05-2011 |
| 20110098798 | Angioplasty Balloon with Therapeutic/Aspiration Channel - An angioplasty balloon catheter with an added channel for delivering medication or removing body fluids distal to the site of angioplasty is disclosed. The balloons are especially useful in the treatment of occlusions in saphenous vein grafts, the coronary and carotid arteries, arteries arising from the aorta and branches thereof and in veins flowing to the heart or their tributaries and sub tributaries thereof. | 04-28-2011 |
| 20110093654 | Memory control - A data processing apparatus | 04-21-2011 |
| 20110092452 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING PANCREATIC CANCER - The present invention provides compositions and methods for treating and diagnosing the presence of solid tumor stem cells in a patient (e.g., based on the presence of c-Met). In certain embodiments, the presence or absence of solid tumor stem cells (e.g., pancreatic solid tumor stem cells) can be determined through the use of a single cells surface marker (e.g., c-Met). The present invention also provides methods for screening candidate compounds (e.g., c-Met antagonists) for the ability to inhibit the tumorigenisis of pancreatic solid tumor stem cells. | 04-21-2011 |
| 20110091952 | METHOD FOR ENZYMATIC PRODUCTION OF DECARBOXYLATED POLYKETIDES AND FATTY ACIDS - Disclosed herein are methods of preparing alkenes from beta-hydroxy or beta-sulfate carboxylic acid or carboxylic acid derivatives using thioesterase and optionally a sulfotransferase. | 04-21-2011 |
| 20110088621 | Organic Vapor Jet Deposition Using an Exhaust - Methods and systems for organic vapor jet deposition are provided, where an exhaust is disposed between adjacent nozzles. The exhaust may reduce pressure buildup in the nozzles and between the nozzles and the substrate, leading to improved deposition profiles, resolution, and improved nozzle-to-nozzle uniformity. The exhaust may be in fluid communication with an ambient vacuum, or may be directly connected to a vacuum source. | 04-21-2011 |
| 20110087861 | System for High-Efficiency Post-Silicon Verification of a Processor - A post-silicon validation technique is able to craft randomized executable code, with known final outcomes, as a verification test that is executable on a hardware, such as a prototype microprocessor. A verification device is able to generate the test, in the form of programs, in such a way that at the end of the execution, the initial state of the test hardware is restored. Therefore, the final state of such a reversible program is known a priori. The technique may use a program generation algorithm, agnostic to any particular instruction set on the test hardware. In some examples, that algorithm is executed on the test hardware to generate the verification test, which is then executed on that test hardware. In other examples, the verification test is generated on another processor coupled to the test hardware. In either case, the verification test may contain initial and inverse operations determined from the test hardware. | 04-14-2011 |
| 20110087117 | REAL-TIME VISUAL ALERT DISPLAY - An alert system for patient treatment that incorporates patient data to display information in readily identifiable icons for vital organs, and in a useable, real-time, updated fashion that extracts data from the medical history, the current medical management, and the current physiologic monitors to produce warnings and alerts to enable practitioners to be made aware of physiologic systems at risk, (physiologic systems in normal range, borderline normal range, and abnormal range of function). These data are not only presented, but also use real-time queries and calculations to enable practitioners to have the types of data that would traditionally assist them in patient care but only be available by reviewing the medical literature and/or doing retrospective individual calculations while providing patient care. | 04-14-2011 |
| 20110078805 | COMPOSITIONS AND METHODS FOR GENERATING TRANSGENIC ANIMALS - The present invention provides methods of altering gene expression of embryos to provide compositions and methods for efficient generation of transgenic animals. In particular, the present invention provides compositions and methods for generating germ-line transgenic animals by direct injection of nucleic acid molecules into animals. | 03-31-2011 |
| 20110070652 | PHAGE MICROARRAY PROFILING OF THE HUMORAL RESPONSE TO DISEASE - The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides methods and compositions for phage microarray profiling of cancer (e.g., prostate, lung, or breast cancer). The present invention further provides novel markers useful for the diagnosis, characterization, and treatment of cancers. | 03-24-2011 |
| 20110065690 | COMPOSITIONS AND METHODS FOR TREATMENT OF LEUKEMIA - The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions. | 03-17-2011 |
| 20110065113 | RECURRENT GENE FUSIONS IN PROSTATE CANCER - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for prostate cancer. | 03-17-2011 |
| 20110064940 | DISPERSION METHOD FOR PARTICLES IN NANOCOMPOSITES AND METHOD OF FORMING NANOCOMPOSITES - A method of manufacturing a nanocomposite includes exposing a plurality of substantially dry nanoparticles to a substantially dry and solid matrix material to form a combination of the nanoparticles and the matrix material. The method also includes agitating the combination of the nanoparticles and the matrix material to thereby disperse the nanoparticles on the matrix material. The matrix material remains in a solid phase during agitating. Furthermore, the method includes processing the combination to form the nanocomposite having the nanoparticles dispersed in the matrix material. | 03-17-2011 |
| 20110062608 | MULTI-PHASIC NANOPARTICLES - A method of forming mufti-phasic nano-objects involves the jetting of two or more different liquids in side-by-side capillaries thereby generating a composite liquid stream. The composite then exposed to a force field which causes the composite liquid stream to at least partially solidify into a nano-object. The method forms a nano-object having a number of morphologies such as rods, spheres, and fibers. | 03-17-2011 |
| 20110059054 | ENHANCED DENDRITIC CELLS FOR CANCER IMMUNOTHERAPY - Described herein are methods of cancer immunotherapy, particularly methods of preparing a population of enhanced dendritic cells and methods of treating cancer using the enhanced dendritic cells. | 03-10-2011 |
| 20110054236 | COMPOSITIONS AND METHODS FOR TARGETING TUMORS - The present invention relates to functionalized magnetic nanoparticles. In particular, the present invention provides functionalized magnetic nanoparticles for research and clinical (e.g., targeted treatment) applications. | 03-03-2011 |
| 20110046189 | HETEROARYL-SUBSTITUTED BICYCLIC SMAC MIMETICS AND THE USES THEREOF - The invention relates to heteroaryl-substituted bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis. | 02-24-2011 |
| 20110044935 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CARDIOMYOPATHY AND HEART DISEASE - The present invention relates to compositions and methods for treating and preventing heart disease. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P188) and methods of using the same for treating and preventing heart disease (e.g., in subjects with muscular dystrophy) and for treating cells and tissue damage caused by ischemia and cell death (e.g., for treating dystrophin-deficient cells (e.g., myocytes)). | 02-24-2011 |
| 20110034872 | Dual Drug Delivery Device - A liquid delivery apparatus for the intrathecal delivery of one or more medications to a patient is disclosed. The liquid delivery apparatus generally includes a liquid reservoir, a liquid metering unit fluidly connected to the liquid reservoir, and a catheter delivery tube fluidly connected to the liquid metering unit. Preferably, the liquid delivery apparatus includes two or more liquid reservoirs. In various embodiments, the liquid reservoir includes a deformable balloon and a compressive sleeve spring as a pressure source, the liquid metering unit is a piezoelectrically actuated microvalve, and/or diagnostic sensors are included in the apparatus. The disclosed apparatus are compact, volume-efficient, energy-efficient, capable of delivering accurate fluid volumes, and address problems associated with multi-medication therapies. Methods of operating the liquid delivery apparatus are also disclosed. | 02-10-2011 |
| 20110034677 | RECURRENT GENE FUSIONS IN PROSTATE CANCER - Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided. | 02-10-2011 |
| 20110033928 | METHODS AND COMPOSITIONS FOR GROWTH OF CELLS AND EMBRYONIC TISSUE ON A SYNTHETIC POLYMER MATRIX - The present invention provides methods and compositions for establishing and maintaining growth of cells and embryonic tissue on a synthetic polymer matrix. For example, the present invention provides synthetic growth matrices for stem cells, gametes, mature differentiated cells, and embryonic tissue (e.g., blastomeres, embryos, and embryoid bodies). In certain embodiments, the cells are capable of going through multiple passages while remaining in an undifferentiated state as a result of the synthetic polymer matrix. | 02-10-2011 |
| 20110033412 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING SKELETAL MUSCLE DEFICIENCIES - The present invention relates to compositions and methods for treating and preventing skeletal muscle deficiencies. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P188) and methods of using the same for treating and preventing skeletal muscle deficiencies and injuries (e.g., dystrophin-deficient skeletal muscle; skeletal muscle having a contraction force deficit; skeletal muscle having a Ca | 02-10-2011 |
| 20110031489 | COMPLEMENTARY THIN FILM ELECTRONICS BASED ON ZnO/ZnTe - A complementary thin-film electronic device structure is provided where one of the transistors has a p-type channel region fabricated from zinc telluride material. The device structure further includes another field effect transistor having an n-type channel region disposed adjacent to and operably coupled to the p-type transistor. | 02-10-2011 |
| 20110028788 | Non-Contact Infrared Fiber-Optic Device for Monitoring Esophageal Temperature to Prevent Thermal Injury During Radiofrequency Catheter Ablation or Cryoablation - An infrared fiber-optic device is able to monitor esophageal temperature during an ablation/cryoablation procedure over a volume of interest to sense whether the temperature is too high or too low. The device may include a plurality of optical fibers each with a wide angle lens collectively disposed circumferentially and longitudinally to cover the volume of interest, as the particular region over which undesirable temperature may not be known beforehand. In other examples, the device may include an embedded array of infrared sensors extending sufficiently to encompass a volume of interest. The device may be used as part of a feedback control to regulate and stop operation of the ablation/cryoablation procedure to prevent vessel damage. | 02-03-2011 |
| 20110028336 | MIPOL1-ETV1 GENE REARRANGEMENTS - Compositions and methods associated with recurrent MIPOL1-ETV1 genetic rearrangements that are useful for cancer diagnosis and therapy are disclosed. | 02-03-2011 |
| 20110027806 | FARNESYLTRANSFERASE INHIBITORS FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING AND ATHEROSCLEROSIS - Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (called “progerin”) that alters normal lamin A function as a dominant negative, as well as assuming its own aberrant function through its association with the nuclear membrane. The retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) (both direct effectors and indirect inhibitors) will inhibit the formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression. Similarly, treatment with FTIs should improve disease status in progeria and other laminopathies. In addition, elements of atherosclerosis and aging in non-laminopathy individuals will improve after treatment with farnesyltransferase inhibitors. | 02-03-2011 |
| 20110025258 | SYSTEM FOR SCHEDULING BATTERY CHARGE AND DISCHARGE - Effective scheduling of battery charge and discharge activities, by making the most of battery characteristics, can extend the battery pack's operation-time and lifetime. A system and method for scheduling battery activities is disclosed. This framework dynamically adapts battery activities to load demands and to the condition of individual battery cells, thereby extending the battery pack's operation-time and making them robust to anomalous voltage imbalances. The scheduling framework includes two components. An adaptive filter estimates the upcoming load demand. Based on the estimated load demand, a scheduler can determine the number of parallel-connected battery cells to be discharged. The scheduler also effectively partitions the battery cells in a pack, allowing the battery cells to be simultaneously charged and discharged in coordination with a reconfigurable battery circuit. | 02-03-2011 |
| 20110021341 | Adsorbents for Organosulfur Compound Removal from Fluids - A method for separating organosulfur compounds from a liquid is provided. The method of this embodiment comprises contacting the liquid with the microporous coordination polymer to form a MCP-organosulfur inclusion compound. | 01-27-2011 |
| 20110020411 | FACTOR REPLACEMENT THERAPY - The present invention provides compositions and methods for providing factor replacement therapy. In particular, the present invention provides replacement therapy for subjects suffering from cystinosis. | 01-27-2011 |
| 20110017663 | SYSTEM AND METHOD FOR SIMULTANEOUS BIOLOGICALLY MEDIATED REMOVAL OF CONTAMINANTS FROM CONTAMINATED WATER - A system and method for simultaneous biologically mediated removal of contaminants (including at least arsenic or nitrate) from water are disclosed herein. The system includes i) a bioreactor having a length suitable for housing at least three different microbial populations, or ii) two bioreactors coupled together, the two bioreactors each having a length and an empty bed contact time that together are suitable for housing at least three different microbial populations. The system also includes a biofilm attachment medium positioned in i) the bioreactor, or ii) the two bioreactors; and the at least three different microbial populations formed on the biofilm attachment medium. The microbial populations are selected from oxygen reducing microbes, nitrate reducing microbes, arsenate reducing microbes, sulfate reducing microbes, and uranium reducing microbes. | 01-27-2011 |
| 20110014716 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING MACULAR DEGENERATION - The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications. | 01-20-2011 |
| 20110012091 | ENHANCEMENT OF ORGANIC PHOTOVOLTAIC CELL OPEN CIRCUIT VOLTAGE USING ELECTRON/HOLE BLOCKING EXCITON BLOCKING LAYERS - The present disclosure relates to photosensitive optoelectronic devices comprising at least one of an electron blocking or hole blocking layer. Further disclosed are methods of increasing power conversion efficiency in photosensitive optoelectronic devices using at least one of an electron blocking or hole blocking layer. The electron blocking and hole blocking layers presently disclosed may reduce electron leakage current by reducing the dark current components of photovoltaic cells. This work demonstrates the importance of reducing dark current to improve power conversion efficiency of photovoltaic cells. | 01-20-2011 |
| 20110009979 | Manufacture of Shape-Memory Alloy Cellular Materials and Structures by Transient-Liquid Reactive Joining - This invention discloses a method, using pure niobium as a transient liquid reactive braze material, for fabrication of cellular or honeycomb structures, wire space-frames or other sparse builtup structures or discrete articles using Nitinol (near-equiatomic titanium-nickel alloy) and related shape-memory and superelastic alloys. Nitinol shape memory alloys (SMAs), acquired in a form such as corrugated sheet, discrete tubes or wires, may be joined together using the newly discovered joining technique. Pure niobium when brought into contact with nitinol at elevated temperature, liquefies at temperatures below the melting point and flows readily into capillary spaces between the elements to be joined, thus forming a strong joint. | 01-13-2011 |
| 20110009393 | Novel Soluble 1,4 Benzodiazepine Compounds and Stable Salts Thereof - The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like. | 01-13-2011 |
| 20110008643 | Manufacture of Shape-Memory Alloy Cellular Materials and Structures by Transient-Liquid Reactive Joining - This invention discloses a method, using pure niobium as a transient liquid reactive braze material, for fabrication of cellular or honeycomb structures, wire space-frames or other sparse builtup structures or discrete articles using Nitinol (near-equiatomic titanium-nickel alloy) and related shape-memory and superelastic alloys. Nitinol shape memory alloys (SMAs), acquired in a form such as corrugated sheet, discrete tubes or wires, may be joined together using the newly discovered joining technique. Pure niobium when brought into contact with nitinol at elevated temperature, liquefies at temperatures below the melting point and flows readily into capillary spaces between the elements to be joined, thus forming a strong joint. | 01-13-2011 |
| 20110004204 | Surgical Instrument and Method for Use Thereof - A surgical instrument for treating a tissue includes a handpiece and a tissue engaging portion arranged to be received by the handpiece. The tissue engaging portion includes first and second opposed jaw members having an open position and a closed position for engaging the tissue therebetween, where the first and second jaw members are arranged to receive surgical energy from a surgical generator. The tissue engaging portion further includes at least one cooling member spaced from at least one of the first and second jaw members, where the cooling member has an open position and a closed position for engaging the tissue. Positioning the jaw members in their closed position and applying surgical energy to the tissue allows for treatment of the tissue, and positioning the cooling member in its closed position provides at least one of a pressure gradient or a thermal gradient between the jaw members and the cooling member. | 01-06-2011 |
| 20110003318 | NUCLEOTIDE AND PROTEIN SEQUENCE OF MAMMASTATIN AND METHODS OF USE - A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and 49 kDa. Metastatic mammary cells either do not express Mammastatin at all, or do not express the 53 kDa or 49 kDa, phosphorylated forms. Mammary cancer cells are inhibited in their growth by the administration of phosphorylated mammastatin. | 01-06-2011 |
| 20100331351 | METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTION - The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against bacterial infections. | 12-30-2010 |
| 20100330611 | Multimodal Spectroscopic Systems and Methods for Classifying Biological Tissue - Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with an empirical equation configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary. | 12-30-2010 |
| 20100327842 | REFERENCE VOLTAGE GENERATOR HAVING A TWO TRANSISTOR DESIGN - An improved voltage reference generator is provided. The voltage reference generator comprises: a first transistor having a gate electrode biased to place the first transistor in a weak inversion mode; and a second transistor connected in series with said first transistor and having a gate electrode biased to place the second transistor in a weak inversion mode, where the threshold voltage of the first transistor is smaller than the threshold voltage of the second transistor and the gate electrode of the second transistor is electrically coupled to a drain electrode of the second transistor and the source electrode of the first transistor to form an output for a reference voltage. | 12-30-2010 |
| 20100323447 | MICROFLUIDIC CELL CULTURE DEVICE AND METHOD FOR USING SAME - Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid. | 12-23-2010 |
| 20100323439 | MICROFLUIDIC CELL CULTURE DEVICE - Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid. | 12-23-2010 |
| 20100317661 | SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF - The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s). | 12-16-2010 |
| 20100316673 | NANOEMULSION VACCINES - The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides immunogenic nanoemulision compositions and methods of using the same to induce immune responses (e.g., immunity (e.g., protective immunity)) against a pathogenic virus of the paramyxoviridae family (e.g., a Paramyxovirinae virus (e.g., | 12-16-2010 |
| 20100310459 | Targeted Detection of Dysplasia In Barrett's Esophagus With A Novel Fluorescence-Labeled Polypeptide - The present invention is directed to compositions and methods for use in detecting dysplasia in Barrett's esophagus. | 12-09-2010 |
| 20100308456 | Wafer-Level, Polymer-Based Encapsulation for Microstructure Devices - A device includes a first device structure having a semiconductor platform, and a second device structure having a microstructure spaced from the semiconductor platform. The device further includes a cable having a plurality of beams to couple the microstructure to the first device structure. Each beam of the plurality of beams has a polymer coating and a serpentine-shaped region. | 12-09-2010 |
| 20100305798 | System And Method For Vehicle Drive Cycle Determination And Energy Management - System and method for vehicle drive cycle determination and energy management is provided. Based on a number of inputs, the system can determine the type of road that the vehicle is likely to drive on as well as the level of traffic congestion that the vehicle is likely to experience. Using these determinations, setpoints for various degrees of freedom, such as engine speed and battery power, can be set to reduce energy usage in the vehicle. | 12-02-2010 |
| 20100305160 | ANESTHETIC METHODS AND COMPOSITIONS - The present invention relates to compositions and methods use in pain reduction, including but not limited to, peripheral nerve blocks. In particular, the present invention relates to compositions and methods for the administration of perineural dexmedetomidine and ropivacaine in combination for increased antinociception in peripheral nerve blocks. In addition, this invention relates to any use of dexmedetomidine alone or in combination with other agents for the purpose of decreasing inflammation around peripheral nerves, thereby decreasing the potential for peripheral nerve injury. Further, the invention relates to the use of dexmedetomidine to reduce inflammation in the muscle to lessen or prevent muscle damage. | 12-02-2010 |
| 20100305075 | COMPOSITION AND METHOD OF TREATING HEARING LOSS - A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is greater than the effect of the individual components alone. The composition includes a biologically effective amount of vitamin E for inhibiting propagation of lipid peroxidation that contributes to hearing loss. The composition also includes a biologically effective amount of a salicylate for reducing hydroxyl radicals that contribute to hearing loss. A method of treating hearing loss includes the step of internally administering the composition, as described above, to a mammal within three days of trauma to a middle or inner ear of the mammal. In other words, the composition is effective even when administered as late as three days after trauma to a middle or inner ear of a mammal. | 12-02-2010 |
| 20100303078 | METHOD FOR EXTENDING THE USE OF SINGLE IPV4 ADDRESSES TO MULTIPLE NETWORK END-HOSTS - An address resolution system is provided where network devices are arranged to share a common public network address in a public network environment. The address resolution system includes: an address resolution table residing at a router and configured to store a public network address and a source port assigned to each network device registered with the router in connection with a hardware address that uniquely identifies each of the registered network devices; a port management agent residing on a given network device that is configured to receive a request to assign a source port to an application residing on the given network device and transmit the assignment request to the router; and an address resolution service residing at the router that is configured to query the address resolution table in response to the assignment request from the agent and transmit a reply to the agent based on results from the query of the address resolution table. | 12-02-2010 |
| 20100297757 | RENAL PROGENITOR CELLS FROM EMBRYONIC STEM CELLS - The present invention relates to compositions and methods for inducing the differentiation of stem cells into renal progenitor cells. In particular, the present invention provides compositions containing activin-a, retinoic acid, and bmp-7, and variants thereof, for differentiating stem cells into renal cells containing tubular epithelia. In certain embodiments, the present invention provides stem cells cultured with compositions used to treat renal disease. | 11-25-2010 |
| 20100297657 | EXPRESSION PROFILE OF PROSTATE CANCER - The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of prostate cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications. | 11-25-2010 |
| 20100294424 | TRANSFORMATION OF NANOSTRUCTURE ARRAYS - A method and apparatus for transforming vertically-aligned nanostructures into densified, horizontally-aligned arrays. A contact element such as a roller is used to topple an array of carbon nanotubes or other nanostructures by drawing or rolling the contact element across the surface of the substrate such that the vertically-aligned nanostructures are forced into at least partial horizontal-alignment while being densified to give the transformed array enhanced properties. The contact element engages the nanostructures at a location below their upper distal end to topple and densify the array without disrupting the relative alignment of the individual nanostructures in the array. Transfer printing of the nanostructures is also provided. | 11-25-2010 |
| 20100291581 | Aldehyde Dehydrogenase 1 (ALDH1) as a Cancer Stem Cell Marker - The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides a novel stem cell cancer marker, ALDH | 11-18-2010 |
| 20100288356 | Photoactive compositions containing plasmon-resonating nanoparticles - Disclosed herein are photoactive compositions that include a semiconductor and plasmon-resonating nanoparticles that are capable of concentrating light at a wavelength that is substantially the same as the wavelength of light necessary to promote an electron from a valance band to a conduction band in the semiconductor. As such, the plasmon-resonating nanoparticles direct light to the band gap of the semiconductor at an increased intensity (relative to when such nanoparticles are not present). And because of that increased intensity, the photoactive composition can be more efficiently used to catalyze a photochemical reaction or generate electrical potential in a photovoltaic cell. | 11-18-2010 |
| 20100287374 | Protecting Hardware Circuit Design by Secret Sharing - Techniques are able to lock and unlock and integrated circuit (IC) based device by encrypting/decrypting a bus on the device. The bus may be a system bus for the IC, a bus within the IC, or an external input/output bus. A shared secret protocol is used between an IC designer and a fabrication facility building the IC. The IC at the fabrication facility scrambles the bus on the IC using an encryption key generated from unique identification data received from the IC designer. With the IC bus locked by the encryption key, only the IC designer may be able to determine and communicate the appropriate activation key required to unlock (e.g., unscramble) the bus and thus make the integrated circuit usable. | 11-11-2010 |
| 20100286053 | PLASMINOGEN ACTIVATOR INHIBITOR AMELIORATION OF NEWBORN HYPOXIC ISCHEMIC BRAIN INJURY - Plasminogen activators as potential therapeutic targets in neonatal hypoxia ischemia (HI) brain injury. Use of plasminogen activator inhibitor-1 (PAI-1) to ameliorate HI encephalopathy related disease. Use of PAI-1 as preventive treatment of cerebral palsy (CP). | 11-11-2010 |
| 20100284539 | Methods for Protecting Against Piracy of Integrated Circuits - Techniques are provided for reducing the likelihood of piracy of integrated circuit design using combinational circuit locking system and activation protocol based on public-key cryptography. Every integrated circuit is to be activated with an external key, which can only be generated by an authenticator, such as the circuit designer. During circuit design, register transfer level (RTL) descriptions of the IC design are embedded with combinational logic based on a master key applied by the authenticator. That combinational logic renders at least one module of the RTL description locked, i.e., encrypted. The completed circuit design from the authenticator is sent to a fabrication lab with the combinationally locked modules. After fabrication, the circuit can only be activated when the authenticator sends an appropriate key that is used by the circuit to unlock the locked portions and thereby activate the circuit. | 11-11-2010 |
| 20100280056 | IDENTIFICATION OF SUBJECTS LIKELY TO BENEFIT FROM STATIN THERAPY - Methods are provided herein to determine if a subject is a candidate for treatment with an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). The method includes determining the presence of at least one polymorphism in the HMGCR gene in a sample from a subject. The presence of at least one polymorphism indicates that the subject is a candidate for treatment with a statin, for example to decrease risk of or treat cancer, cardiovascular disease, diabetes, obesity, inflammatory disease, or auto-immune disease. | 11-04-2010 |
| 20100279301 | METHODS AND COMPOSITIONS FOR DIAGNOSING BLADDER CANCER - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to genes and gene panels as diagnostic markers and clinical targets for bladder cancer. Methods, compositions, and kits for diagnosing, determining, and determining risk of tumor aggressiveness are disclosed. | 11-04-2010 |
| 20100277804 | Spatial-Dispersion-Free Spectral Combining of Pulsed High Peak Power Fiber Laser Beams - A beam combining system suitable of pulsed fiber laser applications is able to produce non-spatial-dispersive beams using an highly efficient filter, such as a multilayer dielectric filter, in transmission and reflection configurations. The techniques therefore can overcome constraints on laser line-width and beam width and allow for more stable systems for high peak power pulsed laser energy, such as may be used in extreme ultraviolet lithography and other applications. | 11-04-2010 |
| 20100273812 | DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF - The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis. | 10-28-2010 |
| 20100273799 | SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF - The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s). | 10-28-2010 |
| 20100268147 | SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF - The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action. | 10-21-2010 |
| 20100268146 | SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF - The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action. | 10-21-2010 |
| 20100266563 | SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF - The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action. | 10-21-2010 |
| 20100266562 | SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF - The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action. | 10-21-2010 |
| 20100261048 | DYNAMICALLY RECONFIGURABLE FRAMEWORK FOR A LARGE-SCALE BATTERY SYSTEM - A dynamically reconfigurable framework is provided for a large-scale battery system. The framework is comprised of a plurality of battery circuits arranged adjacent to each other to form a battery-cell array that is coupled to an application load. A given battery circuit includes: a battery cell with an input terminal and an output terminal; a first switch connected between the load and an input terminal of the battery cell; a second switch is connected between an input terminal of the battery cell and an output terminal of a battery cell in an immediately adjacent battery circuit; and a third switch connected between the output terminal of the battery cell and the output terminal of the battery cell in the adjacent battery circuit. The battery-cell array also includes a local controller that selectively controls the switches in the plurality of battery circuits. | 10-14-2010 |
| 20100261043 | Dynamically Reconfigurable Framework For A Large-Scale Battery System - A dynamically reconfigurable battery framework for management of a large-scale battery system systems is provided. The framework monitors, reconfigures, and controls large-scale battery systems online. The framework is built upon a topology-based bypassing mechanism that provides a set of rules for changing the battery-pack configuration, and a semantic bypassing mechanism by which the battery-cell connectivity is reconfigured to recover from a battery-cell failure. More specifically, the semantic bypassing mechanism implements a constant-voltage-keeping policy and a dynamic-voltage-allowing policy. The former policy is effective in preventing unavoidable voltage drops during the battery lifetime, while the latter policy is effective in supplying different amounts of power to meet a wide-range of application requirements. | 10-14-2010 |
| 20100258004 | MICROPOROUS COORDINATION POLYMERS AS NOVEL SORBENTS FOR GAS SEPARATION - A method of separating a target component from a chemical mixture comprising contacting a chemical mixture with a microporous coordination polymer. The microporous polymer is described by the formula: [M | 10-14-2010 |
| 20100254547 | PIEZOELECTRIC MEMS MICROPHONE - A piezoelectric MEMS microphone comprising a multi-layer sensor that includes at least one piezoelectric layer between two electrode layers, with the sensor being dimensioned such that it provides a near maximized ratio of output energy to sensor area, as determined by an optimization parameter that accounts for input pressure, bandwidth, and characteristics of the piezoelectric and electrode materials. The sensor can be formed from single or stacked cantilevered beams separated from each other by a small gap, or can be a stress-relieved diaphragm that is formed by deposition onto a silicon substrate, with the diaphragm then being stress relieved by substantial detachment of the diaphragm from the substrate, and then followed by reattachment of the now stress relieved diaphragm. | 10-07-2010 |
| 20100248361 | PLATELET PRODUCTION METHODS - The present invention provides platelet production methods. The method comprises the steps of providing a cellular material and culturing the cellular material, wherein platelets are produced. The culturing may be performed on 2D or 3D cell support structure or in suspension culture. In some embodiments, all or a part of the 2D or 3D culturing may be performed in a bioreactor. In some embodiments, the method may further comprise a step of isolating a subset of cells from the starting cellular material, wherein the isolated subset of cells is then cultured, wherein platelets are produced. In yet other embodiments, the method comprises the steps of providing a cellular material, isolating a subset of cells, seeding the subset of cells into a 3D scaffold, culturing the subset of cells in a 3D scaffold, seeding the cultured subset of cells into a bioreactor, culturing the subset of cells in a bioreactor, and harvesting the cells from the bioreactor, wherein platelets are produced. | 09-30-2010 |
| 20100247512 | Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue - Methods are provided for regulating fat storage, carbohydrate metabolism and fatty acid synthesis using modulators of membrane type matrix metalloproteinase 1 (MT1-MMP). | 09-30-2010 |
| 20100235697 | Error detection in precharged logic - An integrated circuit | 09-16-2010 |
| 20100234740 | Method and Apparatus for Evaluating Ocular Tissue Conditions - Methods and apparatus are provided for evaluating an ocular tissue condition of a patient (e.g., a disease, a risk of developing a disease, etc.). For example, an indicator associated with the ocular tissue condition may be generated. A portion of ocular tissue of the patient is irradiated using a light source. Light from the portion of the ocular tissue is received. Raman spectra information associated with the received light is determined. An indicator of an ocular tissue condition is generated based at least on the Raman spectra information. The indicator may, for example, assist a physician in diagnosing or ruling out the ocular tissue condition. | 09-16-2010 |
| 20100233799 | INTEGRATED MICROFLUIDIC CONTROL EMPLOYING PROGRAMMABLE TACTILE ACTUATORS - Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane, for example, a commercial Braille display. The display may be computer controlled, for example by simple text editor software, to activate individual Braille protrusions or a plurality of protrusions to actuate the active portions of the microfluidic device. Integral devices can incorporate the tactile actuators in a single device, but still external to the membrane. | 09-16-2010 |
| 20100228362 | TREMOR STABILIZING SYSTEM FOR HANDHELD DEVICES - A handheld device for canceling unintentional muscle movement. The device includes a base comprising a handgrip for a user to hold, a gripping element linked to the base for releasably connecting the handheld device to an object, a sensor that detects movement of the base, a controller linked to the sensor, and at least one actuator that operates under control of the controller to cause movement of the gripping element in a direction that at least partially counteracts the detected movement of the base. | 09-09-2010 |
| 20100227910 | GENE FUSION TARGETED THERAPY - The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to recurrent gene fusions as clinical targets for prostate cancer. | 09-09-2010 |
