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The Regents of the University of Colorado, a body Corporate

The Regents of the University of Colorado, a body Corporate Patent applications
Patent application numberTitlePublished
20120135424MER DIAGNOSTIC AND THERAPEUTIC AGENTS - Mer diagnostic and therapeutic agents are disclosed. The agents are useful in the diagnosis and treatment of a variety of diseases including leukemia, lymphoma, and clotting disorders.05-31-2012
20120128724SYSTEMS AND METHODS FOR TREATING HUMAN INFLAMMATORY AND PROLIFERATIVE DISEASES AND WOUNDS, WITH FATTY ACID METABOLISM INHIBITORS AND/OR GLYCOLYTIC INHIBITORS - Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherapeutic agents. In preferred embodiments, the invention combines an oxirane carboxylic acid, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and/or an antibody against UCP and/or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers.05-24-2012
20120116252SYSTEMS AND METHODS FOR DETECTING BODY ORIENTATION OR POSTURE - Systems and methods for detecting body orientation and/or posture are provided. At least one wave sensor may be configured to output waves and collect measurements data based upon the reflections of the output waves. At least one processor may be configured to receive measurements data from the at least one wave sensor and evaluate the received measurements data to determine a posture of a monitored subject. Based at least in part upon the determined posture, one or more suitable control actions may be implemented.05-10-2012
20120113513SELF-CLEANING OF OPTICAL SURFACES IN LOW-PRESSURE REACTIVE GAS ENVIRONMENTS IN ADVANCED OPTICAL SYSTEMS - Apparatus and methods for self-cleaning of optical elements in sealed environments over a wide range of operating optical frequencies prevent long-term power degradation by introducing low-pressure backfill of a reactive gas such as oxygen into a vacuum chamber containing the optical elements. The backfill pressure is preferably between 1005-10-2012
20120101162METHODS AND COMPOSITIONS FOR INDUCING PHYSIOLOGICAL HYPERTROPHY - Methods and compositions are provided for inducing physiologic hypertrophy in a cell for treatment or prevention of a cardiovascular disease or condition. In certain embodiments methods and compositions involve an aquaporin 7inducer.04-26-2012
20120092632DIFFRACTION UNLIMITED PHOTOLITHOGRAPHY - Methods, devices, systems, and materials are disclosed for diffraction unlimited photofabrication. A method is provided where a photoresponsive material is illuminated with a first optical pattern at a first wavelength of light. The first wavelength of light alters a solubility of the photoresponsive organic material. The photoresponsive material is also illuminated with a second optical pattern at a second wavelength of light. The second wavelength of light hinders the ability of the first wavelength of light to alter the solubility of the photoresponsive organic material where the second optical pattern overlaps the first optical pattern. The photoresponsive organic material is then developed.04-19-2012
20120087936THERAPEUTIC AND PROPHYLACTIC VACCINE FOR THE TREATMENT AND PREVENTION OF PAPILLOMAVIRUS INFECTION - Embodiments of the present invention provide compositions including a complexes of papillomavirus capsid polypeptide L2 and polypeptide including an immunotherapeutic epitope, and GST fusions thereof. Other embodiments also provide complexes comprising chimeras of papillomavirus L2 polypeptides non-covalently associated with papillomavirus L1 polypeptides, and GST fusions thereof. These compositions may be used to elicit immune responses in a patient to papillomavirus. Therapeutic and prophylactic vaccines for the prevention and treatment of viral infection, especially papillomavirus infection and cervical cancers and warts associated therewith, made from compositions of this invention, are also disclosed. Nucleic acids and expression vectors coding for compositions are also disclosed.04-12-2012
20120070442METHODS AND COMPOSITIONS FOR TREATING CANCER - Provided herein are methods for identifying a cancer patient responsive to treatment with an EGFR tyrosine kinase inhibitor. One method comprises obtaining a biopsy from the patient and measuring the number of copies of miR-12803-22-2012
20120070406THERAPEUTIC PROTEIN COMPOSITIONS HAVING REDUCED IMMUNOGENICITY AND/OR IMPROVED EFFICACY - The present invention provides methods for reducing and/or evaluating the immunogenic potential of a therapeutic protein preparation. The present invention further provides pharmaceutical compositions of therapeutic proteins and methods of treatment with the same, the compositions having low immunogenic potential and/or improved efficacy. The invention achieves these goals by evaluating therapeutic protein preparations for subvisible protein particulates, which can contribute significantly to the overall immunogenic potential of the protein preparation. Further, by maintaining the content of such subvisible protein particulates to below an immunogenic threshold level, the resulting pharmaceutical composition is less likely to result in a loss of tolerance (e.g., upon repeated administration), thereby improving both the safety and efficacy profile of the therapeutic.03-22-2012
20120064009METHODS OF LEUKEMIA CELL DETECTION - Methods are provided for, inter alia, determining the presence of leukemia cells in a subject, determining the change or potential change in the number of leukemia cells in the subject with time, determining whether a tissue in a subject contains a plurality of leukemia cells or a plurality progenitor leukemia cells, and determining whether a leukemia therapy administered to a subject is capable of decreasing the number of leukemia cells in a tissue of the subject.03-15-2012
20120046687Vascular Occlusion Devices - Shape memory materials (SMM) are formed as coil-shaped vascular occlusion devices upon deployment. Shape memory polymer (SMP) materials are tailored through formulation for specific mechanical behavior of the coils. Concurrent coil diameter changes enhance the relative change in stiffness along the length of the coil. Interconnecting structures (02-23-2012
20120046225STABLE GLUCAGON FORMULATIONS FOR THE TREATMENT OF HYPOGLYCEMIA - The delivery of biopharmaceutical and other therapeutic agents parenterally to an animal via a minimally invasive, low pain administration is provided. The agents are delivered to the patient via, e.g., the epidermal, dermal, or subcutaneous layer of the skin in a concentrated form of injectable glucagon that is dissolved in a pharmaceutically acceptable carrier.02-23-2012
20120016102NON-TOXIC BIOFILM INHIBITOR - The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of 01-19-2012
20120016052Stress Relaxation in Crosslinked Polymers - The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention.01-19-2012
20120006194HIGH FLUX SAPO-34 MEMBRANES FOR CO2/CH4 SEPARATION AND TEMPLATE REMOVAL METHOD - The present invention provides methods for making improved zeolite and crystalline silicoaluminophosphate (SAPO) membranes, in particular SAPO-34 membranes, on a porous support through improved removal of the organic structure-directing templating agent. A calcining step is performed in an oxygen free atmosphere, such as under a vacuum or inert gas, to remove the organic templating agent. By removing the templating agent in the absence of oxygen, the calcination step can remove a greater amount of the templating agent than comparable template removal steps conducted in the presence of oxygen and the calcination step can be conducted at significantly lower temperatures. The membranes of the present invention provide increased permeance while maintaining comparable selectivity for gas separations, particularly carbon dioxide (CO01-12-2012
20110282169Long Term Active Learning from Large Continually Changing Data Sets - Methods and systems are disclosed for autonomously building a predictive model of outcomes. A most-predictive set of signals S11-17-2011
20110281679HYBRID TRANSMISSION USING PLANETARY GEARSET FOR MULTIPLE SOURCES OF TORQUE FOR MARINE, OR TWO WHEELED LAND VEHICLES - Provided are alternative hybrid transmission systems for marine, or two wheeled land vehicles, as well as propulsion systems and vehicles comprising such transmission systems, to improve various propulsion systems using a combination of at least two power sources with the option for simultaneous or alternating power input from two or more power sources, while providing desired characteristics or components. Such characteristics or components can include, but are not limited to: power, torque, acceleration, cruising speed or power, fuel efficiency, battery charging, endurance, power sizing, weight, capacity, efficiency, speed, mechanically and/or electrically added system requirements, design, fuel selection, functional design, structural design, lift to drag ratio, weight, and/or other desired characteristic or component.11-17-2011
20110275648FLURBIPROFEN ANALOGS AND METHODS OF USE IN TREATING CANCER - Flurbiprofen analog compounds having an amino acid derivatized at the flurbiprofen alkanoic acid carboxyl group and terminating at an ester or amide group are effective in inhibiting cancer cells in vitro and inhibiting the growth of cancers in viva. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of lung, pancreatic and head and neck cancers.11-10-2011
20110270153CELL STIMULATION USING QUANTUM DOTS - The present invention provides methods for stimulating cells using quantum dots. In addition, the present invention provides methods for treating a variety of clinical conditions using stimulation of quantum dots to induce cell stimulation and/or function.11-03-2011
20110229497Modulating the Alternative Complement Pathway - Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the alternative complement pathway, and methods of identifying factor H-binding proteins.09-22-2011
20110224775Stent Geometry - A non-expandable stent and a method for implanting the stent are provided. The stent includes a generally tubular body having a lumen defined therethrough. The body includes a proximal portion having a curved portion configured for placement proximal to a sphincter. The body further includes a distal portion having retaining member extending outward from a proximal end of the distal portion. The retaining member is configured for placement distal to the sphincter and for engagement of the sphincter.09-15-2011
20110214195Methods For Treating Clinical Conditions Associated With Lipoprotein Lipase Activity - The present invention provides methods for treating a clinical condition associated with lipoprotein lipase activity in the brain of a subject.09-01-2011
20110165143MODULATION OF CASPASES AND THERAPEUTICAL APPLICATIONS - The present invention provides caspase modulators in a wide variety of therapeutic applications. Some aspects of the present invention provide methods for using caspase modulators in treating tumor, promoting wound healing, and producing induced pluripotent stem cells.07-07-2011
20110130344TIGHT JUNCTION PROTEIN MODULATORS AND USES THEREOF - The invention provides tight junction protein modulators, compositions comprising the same, and uses thereof. In particular, the invention provides tight junction protein modulators that modulate the second extracellular loop of tight junction proteins, such as occludin or claudin.06-02-2011
20110112990Efficient Production of Peptides - The present invention relates to processes for the production of peptides, and the peptides produced accordingly. Peptides produced according to the invention may be produced more efficiently than peptides produced according to prior art processes. The production process of the invention may lead to advantages in yield, purity, and/or price. Methods of marketing peptides are also disclosed.05-12-2011
20110097406METHODS AND COMPOSITIONS FOR RETAINING ECM MATERIALS IN HYDROGELS - The present invention provides cell-laden and/or extracellular matrix material laden hydrogels for use in tissue engineering and methods for producing such hydrogels. In some particular embodiments, hydrogels comprise chondrocytes, which are typically encapsulated within the hydrogels. In many instances, such hydrogels are subjected to dynamic loading prior to being administered to a subject to treat a clinical condition that is helped by tissue engineering, including, but not limited to, cosmetic surgery such as craniofacial reconstruction surgery, and cartilage regeneration.04-28-2011
20110091482EXPRESSION OF KIR IN HUMAN CANCER CELLS AS A BIOMARKER FOR IMMUNO-ESCAPE AND CANCER METASTASIS - The present invention is based on the finding that the level of KIR expression in a cancer cell is significant with regard to tumor invasion and metastasis. Therefore, the present invention concerns methods and compositions for evaluating cancer in a patient based on KIR protein or mRNA expression. The invention also provides methods and compositions for treating cancer using a KIR inhibitor and methods of screening for KIR inhibitors.04-21-2011
20110087138NON-INVASIVE DEVICE FOR LOWERING INTRAOCULAR PRESSURE - The present invention provides devices and methods for non-invasively lowering intraocular pressure. In particular, some non-invasive intraocular pressure lowering devices of the invention comprise an oscillating element having a proximal end and a terminal probe. Typically, the terminal probe of said oscillating element comprises a substantially non-abrasive material that is adapted to be in contact with an ocular surface without causing any significant damage to the tissue and is shaped to conform to ocular surface at the limbal region. Devices also include an oscillating mechanism that is operatively connected to the proximal end of said oscillating tip such that when oscillating mechanism is in operation said oscillating tip moves axially without damaging ocular cells. Intraocular pressure lowering devices of the present invention are capable of non-invasively transmitting mechanical force to the tissue proximate to the limbal tissue.04-14-2011
20110063564LIQUID CRYSTAL COMPOSITE, CELL, DEVICE, AND METHOD THEREOF - The invention provides a liquid crystal (LC) composite, a LC cell, a LC device, and a method thereof. The LC composite comprises (i) a liquid crystal material, and (ii) a copolymer polymerized from LC monomers and non-LC-monomers; and the LC composite is mechanically stressed/sheared. The invention exhibits numerous merits such as high transmittance in visible and IR range, hysteresis free, and a simple fabrication process; and may be utilized in LC device applications such as adaptive optics e.g. beam steering devices and fast tip-tilt wavefront correctors; and general optical applications such as eye wears, compact cameras and compact telescopes.03-17-2011
20110054359Footwear-based body weight monitor and postural allocation, physical activity classification, and energy expenditure calculator - A footwear system for monitoring weight, posture allocation, physical activity classification, and energy expenditure calculation includes an accelerometer configured to obtain acceleration data indicative of movement of a user's foot or leg. The footwear system may also include a pressure sensing device mounted in an insole and configured to obtain pressure data indicative of pressure applied by a user's foot to the insole, as well as a transmitter communicatively coupled to both the accelerometer and the pressure sensing device and configured to transmit the acceleration and pressure data to a first processing device configured process the acceleration data and the pressure data to distinguish a first posture from a second posture different from the first posture and process the acceleration data and the pressure data to distinguish a first movement-based activity from a second movement-based activity different from the first movement-based activity. The footwear system may also include a second processing device communicatively coupled to the first processing device and configured to derive a second energy expenditure value.03-03-2011
20110015057MEMBRANES FOR HIGHLY SELECTIVE SEPARATIONS - The present invention provides modified molecular sieve membranes with improved CO01-20-2011
20110007772Phase-matched Generation of Coherent Soft and Hard X-rays Using IR Lasers - Phase-matched high-order harmonic generation of soft and hard X-rays is accomplished using infrared driving lasers in a high-pressure non-linear medium. The pressure of the non-linear medium is increased to multi-atmospheres and a mid-IR (or higher) laser device provides the driving pulse. Based on this scaling, also a general method for global optimization of the flux of phase-matched high-order harmonic generation at a desired wavelength is designed.01-13-2011
20100323348Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process - The present invention provides methods and compositions for detecting and correcting errors in nucleic acid amplification processes, and methods for using the same. In particular, barcode amplification errors are detected and corrected such that integrity in sample assignment is maintained. The methods are compatible with high throughput sequencing techniques as some of the barcodes are based upon Hamming codes, thereby allowing self-correction for single bit errors. Some methods and compositions of the invention allow characterization (e.g., sequencing) of a plurality of nucleic acid samples simultaneously within a single sequencing reaction.12-23-2010
20100284992Phospholipase C and Method of Use - The present invention provides a method for reducing angiogenesis using a phospholipase C.11-11-2010
20100240965MINIMALLY-INVASIVE MEASUREMENT OF ESOPHAGEAL INFLAMMATION - The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the invention comprises a method for measuring esophageal inflammation comprising deploying a device into the esophagus of a subject, removing the device after a predetermined period of time, analyzing the device for a diagnostic indicator of esophageal inflammation and evaluating the diagnostic indicator to diagnose esophageal inflammation.09-23-2010
20100222253METHODS FOR EXTRACTING PLATELETS AND COMPOSITIONS OBTAINED THEREFROM - This invention provides methods for extracting platelets, compositions obtained therefore, and methods for using the same.09-02-2010
20100221304Bionanocomposite Materials and Methods For Producing and Using the Same - The present invention provides bionanocomposite materials comprising at least two coaxial layers of bionanocomposites, and methods for producing and using the same. The bionanocomposite materials of the present invention comprise a core structure and a shell structure encapsulating the core structure, where one of the core structure or the shell structure comprises a porous biocompatible natural-derived material and the other comprises a biocompatible biomimetic nanostructure.09-02-2010
20100219067Electrochemical High Pressure Pump - The invention provides electrochemically-based methods and devices for producing fluid flow and/or changes in fluid pressure. In the methods and devices of the invention, current is passed through a divided electrochemical cell. Adjacent compartments of the cell are divided by a separator which comprises an ionically conducting separator. Each compartment includes an electrode and an electrolyte solution or ionic liquid. The electrolyte solution(s) or ionic liquid(s) and the ionically conducting separator are selected to obtain the desired relationship between the current through the cell and the fluid flowrate and/or change in fluid pressure.09-02-2010
20100192959SHAPE MEMORY POLYMER-BASED TRANSCERVICAL DEVICE FOR PERMANENT OR TEMPORARY STERILIZATION - Transcervical contraceptive devices (TCDs) are disclosed. The TCDs are constructed of shape memory polymer (SMP) materials capable of assuming a memory shape at physiological temperatures. These SMPTCDs (08-05-2010
20100185260METHOD FOR STIMULATING RETINAL RESPONSE USING PHOTOACTIVE DEVICES - An improved method for stimulating electrical activity in an eye is provided. The invention provides a technique for implanting small, nanometer-sized photoactive devices into an eye to improve electrical activity within an eye or mitigate degradation of electrical response in damaged eyes.07-22-2010
20100152839Shape Memory Polymer Prosthetic Medical Device - A prosthetic medical device is formed by the combination of a biological tissue a shape memory polymer structure. The biological tissue provides an in-situ physiological function of the device. The shape memory polymer provides a capability for minimizing the device profile during insertion and then deploying after placement into a memory shape that achieves suitable mechanical structure and stability within an anatomical lumen or cavity. This configuration may be applied to form various prosthetic devices including aortic, mitral, and tricuspid valves in the heart; venous valves; anti-reflux valves for the lower esophageal sphincter; and other biological valve structures. Alternatively, an entirely non-biologic implementation using only shape memory polymer-based structures may be used as a prosthetic valve device.06-17-2010
20100145648SYSTEM AND METHOD FOR CORRECTING SAMPLING ERRORS ASSOCIATED WITH RADIATION SOURCE TUNING RATE FLUCTUATIONS IN SWEPT-WAVELENGTH INTERFEROMETRY - The frequency-sampling method is widely used to accommodate nonlinear electromagnetic source tuning in swept-wavelength interferometric techniques, such as optical frequency domain reflectometry (OFDR) and swept-wavelength optical coherence tomography (OCT). Two sources of sampling errors are associated with the frequency-sampling method. One source of error is the limit of an underlying approximation for long interferometer path mismatches and fast electromagnetic source tuning rates. A second source of error is transmission delays in data acquisition hardware. Aspects of the invention relate to a method and system for correcting to sampling errors in swept-wavelength interferometry systems such that the two error sources correct sampling errors associated with the first radiation path and the second radiation path cancel to second order.06-10-2010
20100144678COMPOSITIONS AND METHODS FOR TREATING BONE CANCER - Small molecule bradykinin inhibitor bisphosphonate amide derivatives useful for inhibiting cancer growth and treating cancer residing in and around bone are disclosed. These compounds and pharmaceutical compositions containing these compounds are particularly useful for the treatment of prostate cancer bone metastases.06-10-2010
20100144007APPARATUS AND METHODS FOR LOADING SOFT MATERIALS - The present invention provides an apparatus for loading soft materials and methods for using the same. In some embodiments, the apparatus is a gearless mechanical loading apparatus which converts a rotational movement of one end of a first element into an arc of a circle movement of the other end of the first element; and converts the arc of a circle movement of the other end of the first element into a precision two-dimensional lateral movement of a second element.06-10-2010
20100105625Product and Methods for Diagnosis and Therapy for Cardiac and Skeletal Muscle Disorders - Disclosed are products and methods to promote myoblast activation and cardiac and skeletal muscle growth or regeneration, and to treat heart and skeletal muscle diseases, based on the identification of cellular processes affected by prelamin A processing.04-29-2010
20100099095METHODS FOR DETERMINING PROGNOSES AND THERAPEUTIC INTERVENTIONS FOR OVARIAN CARCINOMAS - Methods for determining the prognosis and therapeutic interventions for cancer and for utilizing the expression of the homeoprotein Six1 to determine the prognosis and therapeutic interventions for cancer, in particular for ovarian carcinomas.04-22-2010
20100055734Methods for Diagnosis and Intervention of Hepatic Disorders - The disclosure provides a method for quantification of hepatic function in a subject comprising measuring the clearance of an orally administered isotopically labeled cholic acid in a subject with, or suspected of having or developing, a hepatic disorder, for example, chronic hepatitis C. The disclosure further provides methods and kits for assessment of hepatic function.03-04-2010
20100048693Treatment of COPD - The present invention provides methods for treating chronic obstructive pulmonary disease. In some embodiments of the invention, methods for treating COPD comprise administering PGI02-25-2010
20090316141FOURIER DOMAIN SENSING - Methods, systems, and apparatuses are provided for measuring one or more sinusoidal Fourier components of an object. A structured second radiation is generated by spatially modulating a first radiation. The structured second radiation illuminates the object, The structured second radiation is scaled and oriented relative to the object. The object produces a third radiation in response to the illuminating. A single-element detector detects a portion of the third radiation from multiple locations on the object substantially simultaneously for each spatial modulation of the first radiation and for each orientation of the second radiation. A time-varying signal is produced based on said detected portion of the third radiations. One or more characteristics of the one or more sinusoidal Fourier components of the object are estimated based on the time-varying signal.12-24-2009
20090286731METHODS AND COMPOSITIONS FOR THE TREATMENT OF XEROSTOMIA - Methods for the treatment of xerostomia are described, hi particular, the present invention takes advantage of the inventors' observation that xerostomia is caused by induction of apoptosis, and can be inhibited by interfering with the cellular processes that trigger apoptosis in cells receiving chemo- and/or radiotherapy.11-19-2009
20090270528RESIN SYSTEMS FOR DENTAL RESTORATIVE MATERIALS - The disclosure provides a new photopolymerizable resin system for dental restorative materials. The resin system utilizes a thiol-ene component as the reactive diluent in dimethacrylate systems. The ternary resin system comprises a thiol monomer, an ene monomer and a dimethacrylate monomer. Use of an off-stoichiometric ratio of thiol:ene functional groups in favor of excess thiols results in enhanced overall functional group conversion, improved polymer mechanical properties, and reduced shrinkage stress of the ternary system when compared to either traditional dimethacrylate or thiol-ene resin systems.10-29-2009
20080287367Non-Toxic Biofilm Inhibitor - The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of 11-20-2008
20080216650Synthesis of Zeolites and Zeolite Membranes Using Multiple Structure Directing Agents - SAPO-34 membranes and methods for their preparation and use are described. The SAPO-34 membranes are prepared by contacting at least one surface of a porous membrane support with a synthesis gel comprising a first and a second templating agent. SAPO-34 crystals having a narrow size distribution were applied to the surface of the support prior to synthesis. A layer of SAPO-34 crystals is formed on at least one surface of the support. SAPO-34 membranes of the invention can have improved selectivity for certain gas mixtures, including mixtures of carbon dioxide and methane.09-11-2008

Patent applications by The Regents of the University of Colorado, a body Corporate