| THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Patent applications |
| Patent application number | Title | Published |
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| 20130133102 | TARGETING SIGNAL FOR INTEGRATING PROTEINS, PEPTIDES AND BIOLOGICAL MOLECULES INTO BACTERIAL MICROCOMPARTMENTS - A conserved region of sequence in bacterial microcompartment (BMC) enzymes and proteins was identified. Peptide sequences derived from this conserved region of native BMC proteins and enzymes appear to target the hexameric facets of BMC shell proteins. These peptides were predicted to share general properties of a predicted alpha helical conformation, flanked by poorly conserved segment(s) of primary structure); for each type of encapsulated protein, and for each functionally distinct BMC. These peptides can be used as targeting signals for integrating biomolecules and molecules into bacterial microcompartments or for attaching molecules or biomolecules to native or non-native bacterial microcompartment shell proteins. | 05-23-2013 |
| 20130131428 | OPTIMIZATION PROCESS FOR VOLUMETRIC MODULATED ARC THERAPY - Systems, techniques, and processes are disclosed for implementing aperture-based optimization techniques. In one aspect, a method performed by an aperture-based radiation treatment system includes implementing a volumetric modulated arc therapy (VMAT) treatment plan by generating apertures at beam angles. Beam intensities of the generated apertures are determined, which can be used to control generation of a radiation dose in a radiation therapy. | 05-23-2013 |
| 20130131344 | ORGANO-METALLIC FRAMEWORKS DERIVED FROM CARBENOPHILIC METALS AND METHODS OF MAKING SAME - The disclosure provides organic frameworks comprising increased stability. | 05-23-2013 |
| 20130130919 | Long-Range Barcode Labeling-Sequencing - Methods for sequencing single large DNA molecules by clonal multiple displacement amplification using barcoded primers. Sequences are binned based on barcode sequences and sequenced using a microdroplet-based method for sequencing large polynucleotide templates to enable assembly of haplotype-resolved complex genomes and metagenomes. | 05-23-2013 |
| 20130130341 | ELECTRO-AUTOTROPHIC SYNTHESIS OF HIGHER ALCOHOLS - The disclosure provides a process that converts CO | 05-23-2013 |
| 20130130248 | ENDORIBONUCLEASE COMPOSITIONS AND METHODS OF USE THEREOF - The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell. | 05-23-2013 |
| 20130130034 | COMPOSITIONS AND METHODS FOR SYNTHESIS OF ORGANIC-SILICA HYBRID MATERIALS - The present invention relates to compositions and methods for synthesis of organic-silica hybrid microparticles and nanoparticles. In particular, the present invention provides compositions and methods for particle size control during synthesis of organic-silica hybrid microparticles and nanoparticles. | 05-23-2013 |
| 20130129972 | Porous Thin Films - Compositions of porous thin films and methods of making are provided. The methods involve self-assembly of a cyclic peptide in the presence of a block copolymer | 05-23-2013 |
| 20130129687 | Generation of Lineage-Restricted Progenitor Cells from Differentiated Cells - Method for reprogramming differentiated cells into lineage restricted progenitor cells is provided. The method may include contacting differentiated cells with inhibitors of tyrosine phosphatases and apoptosis to de-differentiate differentiated cells into lineage restricted progenitor cells. | 05-23-2013 |
| 20130129668 | Diagnosis and treatment of arthritis using epigenetics - Embodiments of the present invention include methods, compositions and kits for evaluating a diagnosis, prognosis, or response to treatment of a subject with a disorder such as rheumatoid arthritis or osteoarthritis. Some embodiments include identifying a therapeutic agent for treating a disorder such as rheumatoid arthritis or osteoarthritis. | 05-23-2013 |
| 20130127708 | CELL-PHONE BASED WIRELESS AND MOBILE BRAIN-MACHINE INTERFACE - Techniques and systems are disclosed for implementing a brain-computer interface. In one aspect, a system for implementing a brain-computer interface includes a stimulator to provide at least one stimulus to a user to elicit at least one electroencephalogram (EEG) signal from the user. An EEG acquisition unit is in communication with the user to receive and record the at least one EEG signal elicited from the user. Additionally, a data processing unit is in wireless communication with the EEG acquisition unit to receive and process the recorded at least one EEG signal to perform at least one of: sending a feedback signal to the user, or executing an operation on the data processing unit. | 05-23-2013 |
| 20130126892 | P-Type Amorphous GaNAs Alloy as Low Resistant Ohmic Contact to P-Type Group III-Nitride Semiconductors - A new composition of matter is described, amorphous GaN | 05-23-2013 |
| 20130126828 | OPTOELECTRONIC DEVICE BASED ON NON-POLAR AND SEMI-POLAR ALUMINUM INDIUM NITRIDE AND ALUMINUM INDIUM GALLIUM NITRIDE ALLOYS - A high-power and high-efficiency light emitting device with emission wavelength (λ | 05-23-2013 |
| 20130126727 | Time-of-Flight Electron Energy Analyzer - A time-of-flight (TOF) photoemission electron energy analyzer includes a TOF spectrometer for measuring an energy spectrum of a beam of electrons photoemitted from a sample and a 90 degree bend bandpass filter for spatially dispersing and filtering electrons according to energy. An exchange scattering electron spin polarimeter for detecting the spin of electrons includes an entrance aperture for admitting an electron beam, a magnetizable target positionable for receiving the electron beam at an angle relative to a target surface normal vector, a pair of Helmholtz coils positioned about the target for magnetizing the target in a selected direction, and a high-speed multi-channel plate (MCP) detector facing toward the target for receiving electrons reflected from the target surface, the MCP outputting a signal corresponding to the spin dependent intensity and time of electrons' arrivals. | 05-23-2013 |
| 20130123587 | SEM SCANNER SENSING APPARATUS, SYSTEM AND METHODOLOGY FOR EARLY DETECTION OF ULCERS - A handheld, conforming capacitive sensing apparatus configured to measure Sub-Epidermal Moisture (SEM) as a mean to detect and monitor the formation of pressure ulcers. The device incorporates an array of electrodes which are excited to measure and scan SEM in a programmable and multiplexed manner by a battery-less RF-powered chip. The scanning operation is initiated by an interrogator which excites a coil embedded in the apparatus and provides the needed energy burst to support the scanning/reading operation. Each electrode measures the equivalent sub-epidermal capacitance corresponding and representing the moisture content. | 05-16-2013 |
| 20130123349 | AEGYPTIN AND USES THEREOF - The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed. | 05-16-2013 |
| 20130123248 | PHARMACOLOGICAL MODULATION OF POSITIVE AMPA RECEPTOR MODULATOR EFFECTS ON NEUROTROPHIN EXPRESSION - Antagonists of group 1 metabotropic glutamate receptors (mGluR) potentiate the effect of positive AMPA receptor modulators on neurotrophin expression, such as brain-derived neurotrophic factor (BDNF). The findings described herein suggest a combinatorial approach for drug therapies, using both positive AMPA receptor modulators and mGluR antagonists, to enhance brain neurotrophism. | 05-16-2013 |
| 20130123173 | CREATION OF OXIDATION-RESISTANT HDL MIMETIC PEPTIDES - The present invention provides non-naturally occurring polypeptides that are oxidation resistant and have cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABACI that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation; and diagnostic methods employing the peptides to evaluated cholesterol efflux activity. | 05-16-2013 |
| 20130123168 | HUMANIN AND HUMANIN-ANALOGUES FOR THE MANAGEMENT OF ATHEROSCLEROSIS - The present invention is directed to methods and compositions for preventing or reducing atherosclerotic lesions and plaques. Specifically, the instant invention provides methods for using humanin and its analogues to prevent or reduce the formation of atherosclerotic plaques. Also provided are methods of using humanin and its analogues to improve the survival of endothelial cells, particularly aortic endothelial cells. | 05-16-2013 |
| 20130123141 | Cellular Libraries of Peptide Sequences (CLiPS) and Methods of Using the Same - The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme. | 05-16-2013 |
| 20130123130 | MULTIGENE PROGNOSTIC ASSAY FOR LUNG CANCER - The present invention provides methods for providing a prognosis for lung adenocarcinoma, using a panel of eight molecular markers that are differentially expressed in lung adenocarcinoma. | 05-16-2013 |
| 20130122591 | METHODS AND COMPOSITIONS FOR MODIFICATION OF THE HPRT LOCUS - Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals. | 05-16-2013 |
| 20130122195 | METHOD AND DEVICE FOR RESTORING AND MAINTAINING SUPERHYDROPHOBICITY UNDER LIQUID - A superhydrophobic surface includes a plurality of microfeatures disposed on a substrate and a gas generator disposed within the microfeatures, the gas generator configured to generate a gas within the microfeatures. Gas is generated within the microfeatures when at least a portion of the microfeatures is in a wetted state to restore the microfeatures to a dewetted state. Gas generation is self-regulating in that gas generation automatically starts when a wetted condition exists and stops when sufficient gas has been generated to recover a dewetted state that restores superhydrophobicity. | 05-16-2013 |
| 20130122056 | Ratiometric Combinatorial Drug Delivery - The present teachings include ratiometric combinatorial drug delivery including nanoparticles, multi-drug conjugates, pharmaceutical compositions, methods of producing such compositions and methods of using such compositions, including in the treatment of diseases and conditions using drug combinations. | 05-16-2013 |
| 20130122053 | SYNTHETIC TRITERPENOIDS AND TRICYCLIC-BIS-ENONES FOR USE IN STIMULATING BONE AND CARTILAGE GROWTH - The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34. | 05-16-2013 |
| 20130121955 | METHODS AND COMPOSITIONS FOR STABILIZING THE MYOCARDIUM - The present invention provides materials and methods that can serve as a prosthetic and/or, for tissue engineer applications, as a supporting matrix in the stabilization of the myocardium. | 05-16-2013 |
| 20130121925 | OPTICAL DETERMINATION OF GLUCOSE UTILIZING BORONIC ACID ADDUCTS - The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being. | 05-16-2013 |
| 20130121924 | FLUORESCENCE DETECTION OF POISON OAK OIL - The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut. | 05-16-2013 |
| 20130121884 | DEVICE AND METHODS OF DETECTION OF AIRBORNE AGENTS - Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity. | 05-16-2013 |
| 20130121544 | METHOD, SYSTEM, AND APPARATUS FOR PRESSURE IMAGE REGISTRATION - An image registration system and methods that enables mapping of a surface's image scan, such as wound image scans, to each other for comparison and study, due to the variations in the image captures. Correspondence between two images is established and an optimal transformation between two images is determined. The two images (source and target) are either from the same scene acquired at different times or from different views. | 05-16-2013 |
| 20130120083 | Contour-Mode Piezoelectric Micromechanical Resonators - A contour mode micromechanical piezoelectric resonator. The resonator has a bottom electrode; a top electrode; and a piezoelectric layer disposed between the bottom electrode and the top electrode. The piezoelectric resonator has a planar surface with a cantilevered periphery, dimensioned to undergo in-plane lateral displacement at the periphery. The resonator also includes means for applying an alternating electric field across the thickness of the piezoelectric resonator. The electric field is configured to cause the resonator to have a contour mode in-plane lateral displacement that is substantially in the plane of the planar surface of the resonator, wherein the fundamental frequency for the displacement of the piezoelectric resonator is set in part lithographically by the planar dimension of the bottom electrode, the top electrode or the piezoelectric layer. | 05-16-2013 |
| 20130120024 | WAVE DYNAMIC DIFFERENTIAL LOGIC - Wave Dynamic Differential Logic (WDDL) is provided, wherein a differential logic stage is pre-charged or pre-discharged by a previous logic stage, such as, for example, a previous SDDL stage, a WDDL stage, etc. In one embodiment, a Divided Wave Dynamic Differential Logic (DWDDL) is provided wherein a WDDL circuit is conveniently implemented as dual logic trees. | 05-16-2013 |
| 20130118902 | METHODS FOR USING A NANOPORE - The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. | 05-16-2013 |
| 20130116210 | CONTROLLED RELEASE ANTIMICROBIAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS - Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s). | 05-09-2013 |
| 20130116146 | Peptide Microarray and Method of Use - A peptide microarray comprising a plurality of predicted unique binding peptides being selected by computational prediction of interaction with a protein of interest or a domain thereof. The selected unique binding peptides are pre-synthesized and then printed and/or immobilized onto a solid support surface via N-terminus with a linker. Methods of using the invention peptide microarray for quantitative determination of protein-peptide interaction, epitope mapping, and drug screening are also provided. | 05-09-2013 |
| 20130115668 | HOST CELLS AND METHODS FOR PRODUCING FATTY ACID DERIVED COMPOUNDS - The present invention provides for a method of producing one or more fatty acid derived compounds in a genetically modified host cell which does not naturally produce the one or more derived fatty acid derived compounds. The invention provides for the biosynthesis of fatty acid derived compounds such as C18 aldehydes, C18 alcohols, C18 alkanes, and C17 alkanes from C18-CoA which in turn is synthesized from butyryl-CoA. The host cell can be further modified to increase fatty acid production or export of the desired fatty acid derived compound, and/or decrease fatty acid storage or metabolism. | 05-09-2013 |
| 20130115594 | HIGH SPECIFICITY AND HIGH SENSITIVITY DETECTION BASED ON STERIC HINDRANCE & ENZYME-RELATED SIGNAL AMPLIFICATION - The present invention relates to a molecular probe capable of high sensitivity and high specificity detection of a target nucleic acid in a sample. Also disclosed is a detection method using this probe. | 05-09-2013 |
| 20130115267 | COMPOSITIONS AND METHODS FOR REDUCING EDEMA - The invention provides compositions and methods for the treatment and/or reversal of an edema, e.g., including a central nervous system (CNS) edema, e.g., a brain or a spinal edema, edema in a burned or an injured tissue such as skin, or any tissue edema. In alternative embodiments, the invention provides compositions and methods for a direct treatment and reversal of an edema, e.g., CNS, brain or spinal edema, including a membrane transport device, in vitro and in vivo characterization of edema, and the sensitive early optical detection of the edema, e.g., tissue, CNS or cerebral edema. | 05-09-2013 |
| 20130115169 | RED BLOOD CELL-MIMETIC PARTICLES AND METHODS FOR MAKING USE THEREOF - The present technology provides synthesized particles that mimic key structural and functional features of red blood cells. Such RBC-mimicking particles possess the ability to carry oxygen (and carbon dioxide) and flow through capillaries smaller than their own diameter. Further, such particles can also deliver drugs and imaging agents. These particles provide a new paradigm for the design of drug delivery and imaging carriers since they combine the functionality of natural RBCs with the broad applicability and versatility of synthetic drug delivery particles. Further, such particles can be used for detoxification and other biomedical applications. | 05-09-2013 |
| 20130114082 | TEMPERATURE RESPONSE SENSING AND CLASSIFICATION OF ANALYTES WITH POROUS OPTICAL FILMS - Methods and systems of the invention can determine the identity and quantity of analytes in a vapor. In preferred methods, a porous optical film is exposed to vapor which contains analyte. The porous optical film is heated and its optical response is monitored during heating. An optical response observed via heating can determine the identity and/or quantity of the analyte. In preferred embodiments, optical response during a thermal pulse is compared to a database of sensor responses that are characteristic of various analytes. Preferred methods are conducted a relatively low temperatures, for example below about 200° C. In preferred methods, a heating and cooling cycle produces a hysteresis curve in the optical response that is indicative of analytes. In preferred embodiments, a thermal reset pulse resets the porous optical film for later use and also provides an optical response that can be used for sensing. | 05-09-2013 |
| 20130112856 | VACUUM PHOTOSENSOR DEVICE WITH ELECTRON LENSING - A scalable vacuum photosensor configured to simplify mass production with a housing having an evacuated first side at an ultrahigh vacuum and a second side which does not require high vacuum. The first side of the device is sealed to a base plate, having a central electron readout element, using an oxide-free sealing technique, with the deposited sealing areas serving as high voltage throughputs from the first to second sides. A conductive photocathode layer on the transparent first side converts photons to photoelectrons and concentrates the photoelectrons upon the readout. The first and second sides together form an electrostatic lens for accelerating and focusing photoelectrons upon the readout, preferably having a scintillator which generates secondary light measured by an optical detector in the second side of the housing. | 05-09-2013 |
| 20130102880 | METHOD AND APPARATUS FOR PHOTOMAGNETIC IMAGING - A method for photomagnetic imaging of tissue includes the steps of heating the tissue using light; measuring a change in temperature of the tissue with magnetic resonance thermometry; and creating an optical property map from the measured change in temperature. An apparatus for performing photomagnetic imaging of tissue which includes a light source to heat the tissue, a magnetic resonance imaging system to measure a change in temperature of the tissue, and a data processor to generate an optical property map from the measured change in temperature. An optical property map of tissue photomagnetic imaging of tissue produced by: heating the tissue using light; measuring a change in temperature of the tissue with magnetic resonance thermometry; and creating an optical property map from the measured change in temperature. | 04-25-2013 |
| 20130102653 | GNA11 AND GNAQ EXON 4 MUTATIONS IN MELANOMA - The present invention provides methods of detecting activating mutations in exon 4 of a GNAQ or a GNA11 gene in a melanocytic neoplasm for diagnostic and prognostic purposes. The invention further provides methods of treating such melanocytic neoplasm by modulating the activity of the mutated GNAQ or GNA11. | 04-25-2013 |
| 20130102639 | INHIBITORS OF PROTEIN PRENYLTRANSFERASES - The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of protein prenyltransferases including GGTase I and/or RabGGTase. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits. | 04-25-2013 |
| 20130102465 | USE OF A NATURAL METABOLITE TO INCREASE CROP PRODUCTION - Described are compositions and methods to increase bud break in order to increase aspects of one or both of plant vegetative and reproductive growth, by use of a natural metabolite. In particular, the present disclosure provides a natural metabolite either alone or as part of a fertilizer blend to increase crop production. Additionally the present disclosure provides a natural metabolite in combination with one or both of a plant growth regulator and a bio stimulant to increase crop production. | 04-25-2013 |
| 20130101614 | NOVEL LIVE RECOMBINANT BOOSTER VACCINE AGAINST TUBERCULOSIS - Embodiments of the invention comprise an improved vaccine for generating an immune response and preventing or treating mycobacterial diseases such as tuberculosis in humans and animals. Embodiments of the invention also comprise a method for using the vaccine against such mycobacterial diseases. | 04-25-2013 |
| 20130101553 | INDUCING INACTIVATION OF FIBROGENIC MYOFIBROBLASTS - Provided are methods of treating fibrotic conditions in a subject and diagnostic methods for determining fibrosis and appropriate treatments for the fibrosis by the identification of specific subsets of fibrogenic myofibroblasts. | 04-25-2013 |
| 20130101535 | ALDEHYDE DEHYDROGENASE INHIBITORS AS NOVEL DEPIGMENTING AGENTS - The present invention provides methods and compositions for reducing pigmentation. | 04-25-2013 |
| 20130101510 | METHODS OF TREATING PARKINSON'S DISEASE USING VIRAL VECTORS - Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease. | 04-25-2013 |
| 20130100978 | HOLE BLOCKING LAYER FOR THE PREVENTION OF HOLE OVERFLOW AND NON-RADIATIVE RECOMBINATION AT DEFECTS OUTSIDE THE ACTIVE REGION - An (Al,In,B,Ga)N based device including a plurality of (Al,In,B,Ga)N layers overlying a semi-polar or non-polar GaN substrate, wherein the (Al,In,B,Ga)N layers include at least a defected layer, a blocking layer, and an active region, the blocking layer is between the active region and the defected layer of the device, and the blocking layer has a larger band gap than surrounding layers to prevent carriers from escaping the active region to the defected layer. One or more (AlInGaN) device layers are above and/or below the (Al,In,B,Ga)N layers. Also described is a nonpolar or semipolar (Al,In,B,Ga)N based optoelectronic device including at least an active region, wherein stress relaxation (Misfit Dislocation formation) is at heterointerfaces above and/or below the active region. | 04-25-2013 |
| 20130099346 | Back-Side Readout Semiconductor Photomultiplier - This disclosure provides systems, methods, and apparatus related to semiconductor photomultipliers. In one aspect, a device includes a p-type semiconductor substrate, the p-type semiconductor substrate having a first side and a second side, the first side of the p-type semiconductor substrate defining a recess, and the second side of the p-type semiconductor substrate being doped with n-type ions. A conductive material is disposed in the recess. A p-type epitaxial layer is disposed on the second side of the p-type semiconductor substrate. The p-type epitaxial layer includes a first region proximate the p-type semiconductor substrate, the first region being implanted with p-type ions at a higher doping level than the p-type epitaxial layer, and a second region disposed on the first region, the second region being doped with p-type ions at a higher doping level than the first region. | 04-25-2013 |
| 20130099277 | SELECTIVE DRY ETCHING OF N-FACE (Al,In,Ga)N HETEROSTRUCTURES - A method of selective dry etching of N-face (Al,In,Ga)N heterostructures through the incorporation of an etch-stop layer into the structure, and a controlled, highly selective, etch process. Specifically, the method includes: (1) the incorporation of an easily formed, compatible etch-stop layer in the growth of the device structure, (2) the use of a laser-lift off or similar process to decouple the active layer from the original growth substrate, and (3) the achievement of etch selectivity higher than 14:1 on N-face (Al,In,Ga)N. | 04-25-2013 |
| 20130099202 | SUPPRESSION OF RELAXATION BY LIMITED AREA EPITAXY ON NON-C-PLANE (In,Al,B,Ga)N - An (AlInGaN) based semiconductor device, including one or more (In,Al)GaN layers overlying a semi-polar or non-polar III-nitride substrate or buffer layer, wherein the substrate or buffer employs patterning to influence or control extended defect morphology in layers deposited on the substrate; and one or more (AlInGaN) device layers above and/or below the (In,Al)GaN layers. | 04-25-2013 |
| 20130099180 | USE OF ALKALINE-EARTH METALS TO REDUCE IMPURITY INCORPORATION INTO A GROUP-III NITRIDE CRYSTAL GROWN USING THE AMMONOTHERMAL METHOD - Alkaline-earth metals are used to reduce impurity incorporation into a Group-III nitride crystal grown using the ammonothermal method. | 04-25-2013 |
| 20130099115 | MICROFABRICATED HIGH-BANDPASS FOUCAULT APERTURE FOR ELECTRON MICROSCOPY - A variant of the Foucault (knife-edge) aperture is disclosed that is designed to provide single-sideband (SSB) contrast at low spatial frequencies but retain conventional double-sideband (DSB) contrast at high spatial frequencies in transmission electron microscopy. The aperture includes a plate with an inner open area, a support extending from the plate at an edge of the open area, a half-circle feature mounted on the support and located at the center of the aperture open area. The radius of the half-circle portion of reciprocal space that is blocked by the aperture can be varied to suit the needs of electron microscopy investigation. The aperture is fabricated from conductive material which is preferably non-oxidizing, such as gold, for example. | 04-25-2013 |
| 20130098153 | HIGH RANGE DIGITAL ANGULAR RATE SENSOR BASED ON FREQUENCY MODULATION - A digital angular rate sensor system based on frequency modulation (FM) of the rotation rate. The new approach relies on tracking of the resonant frequencies of two high-Q mechanical modes of vibration in a MEMS vibratory gyroscope to produce an inherently digital measurement of the input angular rate. The disclosed system is enabled by a combination of a MEMS vibratory high-Q gyroscope and a new signal processing scheme which takes advantage of a previously ignored gyroscope dynamics effect. The FM nature of the system eliminates noise versus bandwidth and resolution versus dynamic range tradeoffs of conventional vibratory rate gyroscopes. The FM approach allows achieving superior signal-to-noise-ratio through the use of ultra-high Q (1 million) mechanical structure without limiting the measurement bandwidth. Stability of 1e-9 can be achieved in the FM system, providing a 1000 times improvement over the state-of-the-art conventional AM gyroscopes with capacitive pick-off. | 04-25-2013 |
| 20130097754 | MANDARIN TREE NAMED 'KINNOWLS' - ‘KinnowLS’ is a mid- to late-season maturing (depending on climate) diploid mandarin that combines large-sized fruit of excellent quality and production with low seed content even in mixed plantings. It may be successful in the mid-to-late season marketing window that currently has few low-seeded, high quality cultivars. | 04-18-2013 |
| 20130096466 | ENERGY AWARE SENSOR MANAGEMENT FOR WEARABLE MEDICAL SYSTEMS OPTIMIZATION - A sensor system and method configured to take multiple channels of sensors, and based on context and user behavior reflected in the signals, identifies specified channels for sensing according to a sensing policy. The sensing policy is used to reduce the amount of data sampled, such that it is possible to reconstruct the values of the non sampled sensors efficiently. The sensing policy is influenced by user and system's behavior and can be assigned either offline or in real time. | 04-18-2013 |
| 20130096418 | ARTERIAL BLOOD FLOW AND TRANSIT DELAY MEASUREMENT USING ARTERIAL SPIN LABELING - Techniques and systems are disclosed for measuring arterial transit delay using pseudo- continuous arterial spin labeling (ASL) with variable TR and interleaved post-labeling delays. In one aspect, a magnetic resonance imaging method for measure arterial blood flow and transit delay using arterial spin labeling (ASL) includes applying an ASL pulse sequence. The ASL pulse sequence includes a pre- saturation pulse, and a labeling pulse. The method includes performing data acquisition to measure a transit delay, which represents a time needed for labeled blood to arrive in an imaging slice. | 04-18-2013 |
| 20130096210 | METAL-ORGANIC FRAMEWORKS WITH EXCEPTIONALLY LARGE PORE APERATURES - The disclosure relates to metal organic frameworks or isoreticular metal organic frameworks, methods of production thereof, and methods of use thereof. | 04-18-2013 |
| 20130096184 | NKX3-1 SARNA AND KLF4 SARNA AND USES THEREOF - The present disclosure provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a NKX3-1 gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a promoter region sequence of the NKX3-1 gene. The present disclosure also provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a KLF4 gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a promoter region sequence of the KLF4 gene. | 04-18-2013 |
| 20130096159 | INHIBITORS OF HUMAN 12-LIPOXYGENASE - Disclosed are inhibitors of human 12-lipoxygenase of Formula (I) or (II), wherein R | 04-18-2013 |
| 20130096096 | VISCOUS BUDESONIDE FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT - Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention. | 04-18-2013 |
| 20130096095 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR - The present invention provides tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof. The present invention provides a method of using tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof. | 04-18-2013 |
| 20130095528 | BIFIDOBACTERIAL GENE SEQUENCES AND THEIR USE - This invention provides nucleic acids and proteins involved in oligosaccharide modification in the species Bifidobacteria. The invention provides methods for utilizing the proteins of the invention to generate human milk oligosaccharides or oligosaccharide mimics. The invention also provides compositions containing the human milk oligosaccharides or oligosaccharide mimics and methods for use. | 04-18-2013 |
| 20130095475 | GENES FROM THE 20Q13 AMPLICON AND THEIR USES - The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases. | 04-18-2013 |
| 20130095139 | BONE MORPHOGENIC PROTEIN BINDING PEPTIDE - A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis. | 04-18-2013 |
| 20130095075 | BONE MORPHOGENIC PROTEIN BINDING PEPTIDE - A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis. | 04-18-2013 |
| 20130091402 | STRONG SINGLE AND MULTIPLE ERROR CORRECTING WOM CODES, CODING METHODS AND DEVICES - Preferred embodiments of the invention provide WOM coding methods and electronic devices with error correcting codes that provide single, double and triple error correction. Preferred codes of the invention also the following property: if the code corrects two/three errors it has two/three parts of redundancy bits. For double error correction, if only one part of the redundancy bit has no errors then it is possible to correct one error. For triple error correction, if only one/two parts of the redundancy bits have no errors then it is possible to correct one/two errors. Preferred methods of the invention use codes that correct/detect a single, two and three cell-erasures. A preferred method of the invention applies a code that has three roots, ah a2, a3, each of which is a primitive element and where every pair of roots generates a double error correcting code. Methods of the invention further provide and utilize codes utilitizing a triple error correcting WOM code that can correct an arbitrary number of errors. | 04-11-2013 |
| 20130090859 | METHODS AND SYSTEMS FOR GENOME-SCALE KINETIC MODELING - Embodiments of the present invention generally relate to the construction, analysis, and characterization of dynamical states of biological networks at the cellular level. Methods are provided for analyzing the dynamical states by constructing matrices using high-throughput data types, such as fluxomic, metabolomic, and proteomic data. Some embodiments relate to an individual, while others relate to a plurality of individuals. | 04-11-2013 |
| 20130090591 | LOCALIZATION OF AGENTS AT A TARGET SITE WITH A COMPOSITION AND AN ENERGY SOURCE - A method for localizing delivery of an agent to a target site in a subject is provided. The method allows accumulation and/or release of the agent at the target site in the subject through the use of an energy source. | 04-11-2013 |
| 20130090256 | BIOMARKERS FOR EARLY DETECTION OF OVARIAN CANCER - Biomarker proteins that can be used in the diagnosis of early-stage ovarian cancer (OC) are described. The biomarker panels not only permit the distinction of patients with ovarian neoplasia (benign or malignant) from normal subjects, but they also allow the identification of patients with early-stage (stage I/II) ovarian cancer from those patients with benign ovarian tumors or normal individuals. The invention additionally provides methods for detecting and treating various cancers, including cancer of the ovary using OC-related molecules. | 04-11-2013 |
| 20130087766 | SCALABLE QUANTUM COMPUTER ARCHITECTURE WITH COUPLED DONOR-QUANTUM DOT QUBITS - A quantum bit computing architecture includes a plurality of single spin memory donor atoms embedded in a semiconductor layer, a plurality of quantum dots arranged with the semiconductor layer and aligned with the donor atoms, wherein a first voltage applied across at least one pair of the aligned quantum dot and donor atom controls a donor-quantum dot coupling. A method of performing quantum computing in a scalable architecture quantum computing apparatus includes arranging a pattern of single spin memory donor atoms in a semiconductor layer, forming a plurality of quantum dots arranged with the semiconductor layer and aligned with the donor atoms, applying a first voltage across at least one aligned pair of a quantum dot and donor atom to control a donor-quantum dot coupling, and applying a second voltage between one or more quantum dots to control a Heisenberg exchange J coupling between quantum dots and to cause transport of a single spin polarized electron between quantum dots. | 04-11-2013 |
| 20130087182 | SOLAR CELLS ARRANGEMENT - A solar energy conversion system is presented. The system comprises at least one waveguide arrangement having at least one light input respectively. The waveguide arrangement comprises a core unit for passing input solar radiation therethrough and a cladding material arrangement interfacing with the core therealong. The cladding material arrangement is configured as an array of spaced-apart solar cells arranged along the core unit and having different optical absorption ranges, such that an interface between the waveguide core and the cladding arrangement spectrally splits the photons of the input solar radiation by causing the photons of different wavelengths, while passing through the core unit, to be successively absorbed and thereby converted into electricity by the successive solar cells of said array. | 04-11-2013 |
| 20130084464 | Inorganic Nanostructure-Organic Polymer Heterostructures Useful for Thermoelectric Devices - The present invention provides for an inorganic nanostructure-organic polymer heterostructure, useful as a thermoelectric composite material, comprising (a) an inorganic nanostructure, and (b) an electrically conductive organic polymer disposed on the inorganic nanostructure. Both the inorganic nanostructure and the electrically conductive organic polymer are solution-processable. | 04-04-2013 |
| 20130080681 | EFFICIENT TWO WRITE WOM CODES, CODING METHODS AND DEVICES - The invention provides a family of 2-write WOM-codes, preferred embodiments of which provide improved WOM-rates. Embodiments of the invention provide constructs for linear codes C having a 2-write WOM-code. Embodiments of the invention provide 2-write WOM-codes that improve the best known WOM-rates known to the present inventors at the time of filing with two writes. Preferred WOM-codes are proved to be capacity achieving when the parity check matrix of the linear code C is chosen uniformly at random. Preferred embodiments of the invention provide an electronic device utilizing an efficient coding scheme of WOM-codes with two write capability. The coding) method is based on linear binary codes and allows the electronic device to write information to the memory twice before erasing it This method can be applied for any kind of memory systems, and in particular for flash memories. The method is shown to outperform all well-known codes. | 03-28-2013 |
| 20130079748 | STEPPED CANNULA - Described herein are cannulas having a stepped exterior. Also described are methods of making and using these cannulas, for example to deliver one or more materials to the central nervous system of an animal. | 03-28-2013 |
| 20130078683 | Host Cells and Methods for Producing Cinnamoyl Anthranilate and Analogs Thereof - The present invention provides for a method of producing a cinnamoyl anthranilate, or analog thereof, in a genetically modified host cell. | 03-28-2013 |
| 20130078622 | ELECTRONIC DEVICE FOR MONITORING SINGLE MOLECULE DYNAMICS - A single molecule sensing device includes a first electrode, a second electrode and a single-walled carbon nanotube (SWNT) connected to the first and second electrodes. At least one linker molecule having first and second functional groups is functionalized with a sidewall of the SWNT, the at least one linker molecule having the first functional group non-covalently functionalized with a sidewall of the single-walled carbon nanotube. A single sensitizing molecule having at least one functional group is functionalized with the second functional group of the at least one linker molecule. | 03-28-2013 |
| 20130078508 | LITHIUM ION BATTERIES BASED ON NANOPOROUS SILICON - A lithium ion battery that incorporates an anode formed from a Group IV semiconductor material such as porous silicon is disclosed. The battery includes a cathode, and an anode comprising porous silicon. In some embodiments, the anode is present in the form of a nanowire, a film, or a powder, the porous silicon having a pore diameters within the range between 2 nm and 100 nm and an average wall thickness of within the range between 1 nm and 100 nm. The lithium ion battery further includes, in some embodiments, a non-aqueous lithium containing electrolyte. Lithium ion batteries incorporating a porous silicon anode demonstrate have high, stable lithium alloying capacity over many cycles. | 03-28-2013 |
| 20130078448 | METHOD OF MAKING ELECTROCHEMICAL DEVICE WITH POROUS METAL LAYER - A method is described for producing layered structures comprising a porous metal layer and a ceramic containing layer comprising wherein a porous green ceramic layer is provided, and thereafter loose metal particles are applied to the green ceramic layer before sintering. In one embodiment, the green ceramic layer, after application of the loose metal particles, is dried to drive off the solvent and cause interpenetration of the metal particles. In another embodiment loose particles can be removed from the composite such as by shaking, and the green ceramic/loose metal particles composite compressed to cause further interpenetration of the metal particles prior to sintering. | 03-28-2013 |
| 20130078223 | Method And Composition For Inducing Human Pluripotent Stem Cells - The present invention provides pluripotent stem cell like (PSCL) cells or clones, a culture medium therefore, and a supernatant thereof, and methods of making and using the same. | 03-28-2013 |
| 20130078188 | ACTIVATABLE CELL PENETRATING PEPTIDES WITH QUENCHED FLUOROPHORES - The invention provides compositions useful as molecular probes. In particular, the invention provides activatable cell penetrating peptides comprising a fluorescence donor and a fluorescence acceptor. Exemplary fluorescence donors and fluorescence acceptors include compounds derived from cyanine. Also provided are ratiometric, multispectral, and excitation lifetime imaging methods for detecting the molecular probes provided herein. | 03-28-2013 |
| 20130074304 | Temperature-Robust MEMS Gyroscope with 2-DOF Sense-Mode Addressing the Tradeoff Between Bandwidth and Gain - The current invention is a novel gyroscope design, which yields devices robust to fabrication and environmental variations, allows flexible selection of operational parameters, and provides increased bandwidth with minimized sacrifice in gain regardless of the selected frequency of operation. The gyroscope has a single degree-of-freedom (DOF) drive-mode and a 2-DOF sense-mode. The drive-mode operational frequency and the sense-mode bandwidth can be selected arbitrarily in the proposed design, relaxing the tradeoff between the gain, die size, and detection capacitance. The symmetry of the structure ensures the optimal location of the drive-mode resonance relative to the sense-mode operational region, even in presence of fabrication imperfections. | 03-28-2013 |
| 20130074232 | Avocado rootstock named 'Steddom' - A new and distinct | 03-21-2013 |
| 20130074231 | Avocado rootstock named 'Zentmyer' - A new and distinct variety of | 03-21-2013 |
| 20130074230 | Avocado variety named 'Uzi' - A new and distinct | 03-21-2013 |
| 20130072959 | Non-Fragmenting Low Friction Bioactive Absorbable Coils for Brain Aneurysm Therapy - Non-fragmenting low friction bioactive absorbable coils are disclosed that improve long-term anatomic results in the endovascular treatment of intracranial aneurysms. The coils are composed of at least one biocompatible and bioabsorbable polymer. The coils are then coated with a polymer to reduce the friction. The coating can contain drugs, such as growth factors, and can be used to accelerate histopathologic transformation in aneurysms. The coil can be a polymer such as polyglycolic acid (PGA), poly-L-lactic acid (PLLA), polycaprolactive, poly-L-lactide, polydioxanone, polycarbonates, polyanhydrides, polyglycolic acid/poly-L-lactic acid copolymers, polyhydroxybutyrate/hydroxyvalerate copolymers, or combinations thereof. | 03-21-2013 |
| 20130072511 | ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES - Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders. | 03-21-2013 |
| 20130071542 | COMPOSITIONS AND METHODS FOR REDUCING H2S LEVELS IN FERMENTED BEVERAGES - The present invention provides compositions and methods for reducing H | 03-21-2013 |
| 20130069088 | LIGHT EMITTING DIODE WITH CONFORMAL SURFACE ELECTRICAL CONTACTS WITH GLASS ENCAPSULATION - An optoelectronic device (e.g., LED) comprising one or more conformal surface electrical contacts conforming to surfaces of the device; and a high refractive index glass partially or totally encapsulating the device and the conformal surface electrical contacts, wherein traditional wire bonds and/or bond pads are not used and the glass is a primary encapsulant for the device. | 03-21-2013 |
| 20130068963 | SHIELDED CAPACITIVE ELECTRODE - A device is described, which is sensitive to electric fields, but is insensitive to stray electrons/ions and unlike a bare, exposed conductor, it measures capacitively coupled current while rejecting currents due to charged particle collected or emitted. A charged particle beam establishes an electric field inside the beam pipe. A grounded metallic box with an aperture is placed in a drift region near the beam tube radius. The produced electric field that crosses the aperture generates a fringe field that terminates in the back surface of the front of the box and induces an image charge. An electrode is placed inside the grounded box and near the aperture, where the fringe fields terminate, in order to couple with the beam. The electrode is negatively biased to suppress collection of electrons and is protected behind the front of the box, so the beam halo cannot directly hit the electrode and produce electrons. The measured signal shows the net potential (positive ion beam plus negative electrons) variation with time, as it shall be observed from the beam pipe wall. | 03-21-2013 |
| 20130066402 | ENGINEERED RED-SHIFTED CHANNELRHODOPSIN VARIANTS - The invention provides engineered red-shifted channelrhodopsin variants. In some embodiments, the channelrhodopsin variants are characterized by improved membrane trafficking, expression, and/or unique spectral and kinetic properties. | 03-14-2013 |
| 20130065936 | MODULATION OF BIOACTIVE EPOXY-FATTY ACID LEVELS BY PHOSPHODIESTERASE INHIBITORS - The present invention provides method for increasing levels of epoxygenated fatty acids by administration of a phosphodiesterase inhibitor. | 03-14-2013 |
| 20130065872 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS - The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs. | 03-14-2013 |
| 20130065769 | SALIVARY BIOMARKERS FOR GASTRIC CANCER DETECTION - Disclosed herein are biomarkers related to gastric cancer. The presently identified salivary biomarkers create the basis for a gastric cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed gastric cancer assay in clinical, diagnostic and therapeutic uses is also included. | 03-14-2013 |
| 20130064837 | INTEGRIN ALPHA-V BETA8 NEUTRALIZING ANTIBODY - The present invention relates to ανβ8 antagonists, anti-ανβ8 antibodies or immunoconjugates for reducing TGFβ activation in an individual. Further provided are compositions comprising one of the ανβ8 antagonists, anti-ανβ8 antibodies or immunoconjugates, methods for using the compositions, and related subject matter. | 03-14-2013 |
| 20130064759 | COPOLYMER-STABILIZED EMULSIONS - An emulsion includes a substantially continuous liquid medium, and a plurality of droplet structures dispersed within the substantially continuous liquid medium. Each droplet structure of the plurality of droplet structures includes an outer droplet of a first liquid having an outer surface; an inner droplet of a second liquid within the first droplet, the second liquid being immiscible in the first liquid, wherein the inner and outer droplets have a boundary surface region therebetween; an outer layer of block copolymers disposed on the outer surface of the outer droplet; and an inner layer of block copolymers disposed on the boundary surface region between the outer and the inner droplets. | 03-14-2013 |
| 20130064750 | METHOD AND DEVICE TO SYNTHESIZE BORON NITRIDE NANOTUBES AND RELATED NANOPARTICLES - Methods and apparatus for producing chemical nanostructures having multiple elements, such as boron and nitride, e.g. boron nitride nanotubes, are disclosed. The method comprises creating a plasma jet, or plume, such as by an arc discharge. The plasma plume is elongated and has a temperature gradient along its length. It extends along its length into a port connector area having ports for introduction of feed materials. The feed materials include the multiple elements, which are introduced separately as fluids or powders at multiple ports along the length of the plasma plume, said ports entering the plasma plume at different temperatures. The method further comprises modifying a temperature at a distal portion of or immediately downstream of said plasma plume; and collecting said chemical nanostructures after said modifying. | 03-14-2013 |
| 20130062285 | Oil-Tolerant Polymer Membranes for Oil-Water Separations - The invention relates to oil-tolerant water-filtration membranes comprising a microporous hydrogel coated on a porous polymeric support membrane, useful in separating hydrocarbons and hydrocarbon emulsions from a water sample. The oil-tolerant water-filtration membranes comprising a hydrophilic microporous crosslinked polymeric hydrogel coated on at least one side of a porous polymeric support membrane. The water-filtration membrane having a first face corresponding to the discrimination layer and a second face corresponding to the porous support, applying pressure to a water solution, having at least one solute, at the first face of the water-filtration membrane, and collecting purified water at the second face of water-filtration membrane. Polymeric membranes have many advantages over ceramics, including inexpensive manufacture and the ability to be manufactured into very compact (high surface area) elements. | 03-14-2013 |
| 20130062211 | NANOMATERIAL-BASED GAS SENSORS - A gas sensing device (nanosensor) includes a substrate with at least a pair of conductive electrodes spaced apart by a gap, and an electrochemically functionalized semiconductive nanomaterial bridging the gap between the electrodes to form a nanostructure network. The nanomaterial may be single-walled carbon nanotubes (SWNTs) functionalized by the deposition of nanoparticles selected from the group consisting of an elemental metal (e.g., gold or palladium), a doped polymer (e.g., camphor-sulfonic acid doped polyaniline), and a metal oxide (e.g. tin oxide). Depending on the nanoparticles employed in the functionalization, the nanosensor may be used to detect a selected gas, such as hydrogen. mercury vapor, hydrogen sulfide, nitrogen dioxide, methane, water vapor, and/or ammonia, in a gaseous environment. | 03-14-2013 |
| 20130060166 | DEVICE AND METHOD FOR PROVIDING HAND REHABILITATION AND ASSESSMENT OF HAND FUNCTION - The various embodiments provided herein are generally directed to a method, system, and/or device for providing rehabilitation and assessing function from a portion of the human body. In one embodiment, there is disclosed a method, system, and/or device for providing rehabilitation and assessing of hand function using an audio interface. The audio interface may be a music-based interface and device may include a monitor unit, such as a hand monitoring unit, for providing data of a movement to a computing device, such as a microcontroller. The computing device may output data to a music-based interface. | 03-07-2013 |
| 20130059747 | MULTIGENE PROGNOSTIC ASSAY FOR LUNG CANCER - The present invention provides methods for providing a prognosis for lung cancer using a panel of eleven molecular markers that includes BAG1, BRCA1, CDC6, CDK2AP1, ERBB3, FUT3, IL11, LCK, RND3, SH3BGR, and WNT3A, which are differentially expressed in lung cancer. The eleven markers are related to patient prognosis to 5-year overall survival outcomes, and are particularly useful in providing a prognosis for non-squamous NSCLC. | 03-07-2013 |
| 20130059295 | Host Cells and Methods for Producing Fatty Acid - The present invention provides for a genetically modified host cell capable of producing fatty acid comprising an increased expression of FadR, or a functional variant thereof. The host cell under environmental conditions wherein fatty acid is produced expresses an increased amount of FadR when compared to an unmodified host cell. The present invention also provides for a method of producing a fatty acid or FAAE in the host cell. The present invention provides for a genetically modified host cell comprising a fatty acid biosensor and one or more fatty acid-responsive promoter operably linked to one or more genes of interest that is heterologous to the fatty acid-responsive promoter. | 03-07-2013 |
| 20130058938 | GNA11 MUTATIONS IN MELANOMA - The present invention provides methods of detecting mutations in a GNA11 gene in a melanocytic neoplasm for diagnostic and prognostic purposes. The invention further provides methods of treating such melanocytic neoplasm by modulating the activity of the mutated GNA11 gene. | 03-07-2013 |
| 20130058896 | COMPOSITIONS AND METHODS RELATED TO ANTI-FGF AGENTS - The invention relates to an isolated amino acid that can act as an antagonist to FGF signaling, comprising at least a portion of the FGF protein amino acid sequence, and including a mutation in either a) the integrin αvβ3 binding region of FGF-1; or b) the FGFR binding region of FGF-1. | 03-07-2013 |
| 20130058370 | PLANAR, HIGH NA, LOW LOSS TRANSMITTING OR REFLECTING LENSES USING SUB-WAVELENGTH HIGH CONTRAST GRATING - Planar lenses and reflectors are described comprising subwavelength high-contrast gratings (HCG) having high index of refraction grating elements spaced apart from one another in straight and/or curved segments and surrounded by low index material. The high-contrast grating is configured to receive an incident wave which excites multiple modes within the high-contrast grating and is focused for reflection and/or transmission by said high contrast grating. The width of the high contrast grating bars vary along a distribution direction of the grating bars which is perpendicular to the length of the grating bars and/or varies along the length of one or more grating bars to focus said reflection and/or transmission. The HCG is configured to provide double focusing, whose use is exemplified within a vertical cavity surface emitting laser (VCSEL) structure using focusing HCG structures for both the top and bottom mirrors. | 03-07-2013 |
| 20130057857 | IMPEDANCE MATCHING GROUND PLANE FOR HIGH EFFICIENCY COUPLING WITH OPTICAL ANTENNAS - An optical nanoantenna ground plane apparatus and method which enhances electric field intensity, surface-enhanced Raman spectroscopy (scattering). A dielectric spacer layer is disposed between a nanoantenna layer and a metallic ground plane layer. Thickness of the dielectric spacer layer is determined in response to matching metal loss resistance and radiation resistance of the optical nanoantenna layer for a given optical antenna configuration and operating wavelength, such as in response to finite difference time domain (FDTD) simulations which determine dielectric spacer layer thickness when radiation quality factor and absorption quality factor are equal. The inventive ground plane can be implemented for a wide range of optical applications regardless of whether fabrication of the nanoantenna-groundplane combination is fabricated in a top-down or bottom-up sequence. | 03-07-2013 |
| 20130055413 | System and Method of Managing Protected Video Content - A method includes inspecting a packet stream sent from a set-top box device via a network. The packet stream includes video content that is divided into a plurality of subsections. The method includes generating a plurality of signatures by applying a wavelet transform to each of the plurality of subsections, and determining a match between the video content and protected video content based at least in part on a comparison of the plurality of signatures to one or more stored signatures generated based on the protected video content. | 02-28-2013 |
| 20130054662 | METHODS OF USING GENERALIZED ORDER DIFFERENTIATION AND INTEGRATION OF INPUT VARIABLES TO FORECAST TRENDS - Disclosed are methods and apparatuses to generate a forecast based on generalized differentiation or integration, including but not limited to non-integer or variable order differentiation or integration. | 02-28-2013 |
| 20130053585 | GAS SEPARATIONS WITH REDOX-ACTIVE METAL-ORGANIC FRAMEWORKS | 02-28-2013 |
| 20130052728 | COMPOSITIONS AND METHODS FOR MAKING AND USING BONE MARROW MESENCHYMAL STEM CELLS AND ERYTHROID PROGENITOR CELLS - The invention provides compositions for making erythroid progenitor cells that comprise in vitro-activated bone marrow mesenchymal stem cells and embryoid bodies (EBs) or pluripotent stem cells, and methods for making and using them, including ameliorating (e.g., preventing or treating) anemia and/or stimulating erythropoiesis. In one embodiment, the invention provides methods of increasing propensity of committed stem cell differentiation towards the erythroid lineage. | 02-28-2013 |
| 20130051419 | HCG REFLECTION ENHANCEMENT IN DIVERSE REFRACTIVE INDEX MATERIAL - Enhanced reflectivity High-Contrast Gratings are described which operate in different medium. An HCG is described with a deep/buried metallization layer separated at a distance of least three to four grating thicknesses from the grating. Reflective bandwidth of the HCG is substantially increased, such as by a factor or five, by inclusion of the deep/buried metallization layer. An HCG is described which provides high reflectivity, even when embedded into materials of a moderate to high index of refraction, such as semiconductor material. Vertical cavity surface emitting laser embodiments are described which utilize these reflectivity enhancements, and preferably utilize HCG reflectors for top and/or bottom mirrors. | 02-28-2013 |
| 20130046274 | METHOD OF CONTROLLED DELIVERY USING SUB-MICRON-SCALE MACHINES - A method for controlled delivery of a substance into a body includes administering a plurality of containment vessels into the body, in which each of the plurality of containment vessels includes a quantity of the substance loaded therein prior to the administering; and providing a time-varying magnetic field such that the plurality of containment vessels are exposed thereto to cause a release of at least a portion of the substance from the plurality of containment vessels. Each of the plurality of containment vessels has an average outer diameter less than about 1 μm. | 02-21-2013 |
| 20130045950 | Phosphonate Compounds - The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like. | 02-21-2013 |
| 20130045925 | COMPOSITIONS FOR AMELIORATING CELL PROLIFERATIVE DISORDERS AND METHODS OF MAKING AND USING THEM - In alternative embodiments, the invention provides apratoxin F and apratoxin G compounds, which include apratoxin F and apratoxin G stereoisomers, derivatives and analogs compositions and methods. In alternative embodiments, the invention provides pharmaceutical compositions and formulations comprising apratoxin F (compound 6 of FIG. | 02-21-2013 |
| 20130045172 | USE OF CIS-EPOXYEICOSATRIENOIC ACIDS AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO TREAT CONDITIONS MEDIATED BY PBR, CB2, and NK2 RECEPTORS - The invention relates to the discovery that cis-epoxyeicosatraenoic acids (EETs) bind to and act as agonists of peripheral benzodiazepine receptor and the cannabinoid CB | 02-21-2013 |
| 20130044960 | COIL COMPRESSION FOR THREE DIMENSIONAL AUTOCALIBRATING PARALLEL IMAGING WITH CARTESIAN SAMPLING - A three dimensional image, in a phased array magnetic resonance imaging (MRI) system is provided. Three dimensional k-space data within an auto calibration signal (ACS) region and outside the ACS region are acquired. The k-space data within the ACS region are converted into hybrid space ACS data. Compression matrices and alignment matrices of the compression matrices for the hybrid space ACS data are found along a readout direction. Alignment matrices are multiplied to the compression matrices to achieve the properly-aligned compression matrices along the readout direction. All k-space data are converted into hybrid space. The properly-aligned compression matrices are applied to the hybrid space data to provide compressed data with fewer channels. The compressed data are used to form a three dimensional image. | 02-21-2013 |
| 20130043121 | Method and Apparatus for Sputtering with a Plasma Lens - A plasma lens for enhancing the quality and rate of sputter deposition onto a substrate is described herein. The plasma lens serves to focus positively charged ions onto the substrate while deflecting negatively charged ions, while at the same time due to the line of sight positioning of the lens, allowing for free passage of neutrals from the target to the substrate. The lens itself is formed of a wound coil of multiple turns, inside of which are deposed spaced lens electrodes which are electrically paired to impress an E field overtop the B field generated by the coil, the potential applied to the electrodes increasing from end to end towards the center of the lens, where the applied voltage is set to a high potential at the center electrodes as to produce a potential minimum on the axis of the lens. | 02-21-2013 |
| 20130041289 | MECHANICAL PIVOT SHIFT MEASUREMENT TO EVALUATE JOINTS - An unmet need of orthopaedic practitioners is a clinically-relevant measurement device and technique to objectively quantify joint (e.g., knee) stability, including rotational stability. An apparatus and method is disclosed for performing a mechanical joint movement test, such as a knee pivot shift test, through the application of standardized dynamic loads (e.g., using a constant-tension spring or other mechanism). When used for knee evaluation, this test reliably induces the characteristic “pivot” tibial subluxation/reduction event in an ACL-deficient knee, allowing for more sensitive detection of deficiencies in rotational knee stability, quantification of the relative importance of knee stabilizers, and comparison of the performance of contemporary ACL reconstruction techniques. The test allows for better understanding joint biomechanics and for defining unique kinematic and kinetic signatures for common joint injuries, such as knee injuries, that will be valuable for diagnostic purposes. | 02-14-2013 |
| 20130040904 | METHOD OF TREATMENT USING ALPHA-1-ADRENERGIC AGONIST COMPOUNDS - Methods for treating or preventing cardiomyopathy in a subject by administering an α1 adrenergic receptor agonist, wherein the treatment does not result in increased blood pressure are provided. | 02-14-2013 |
| 20130040369 | Gammaretrovirus Associated With Cancer - The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus. | 02-14-2013 |
| 20130038868 | IDENTIFICATION OF OBJECTS USING PLASMON RESONANT PARTICLES - A method and apparatus for identifying an object having a pattern of plasmon resonant particles (PREs) distributed in or on the object are disclosed. In the method, a field containing the pattern is illuminated, and one or more spectral emission characteristics of the light-scattering particles in the field are detected. From this data, an image of positions and spectral characteristic values in the field is constructed, allowing PREs with a selected spectral signature to be discriminated from other light-scattering entities, to provide information about the field. The image may be compared to a database of reference images to identify or validate the object. | 02-14-2013 |
| 20130038470 | MULTIMODAL CLIMATE SENSOR NETWORK - Techniques and systems are disclosed for monitoring multiple indoor and outdoor climate parameters and wirelessly transmitting the monitored data to a network for on-line analysis and dissemination. In one aspect, a monitoring device includes multiple sensors to monitor air quality modalities and generate corresponding monitored air quality data. The monitoring device includes a processor in communication with the multiple sensors to receive and process the monitored air quality data generated from the multiple sensors. Additionally, the monitoring device includes a display unit in communication with the processor to display the processed air quality data. The monitoring device includes a data communication unit to transmit the processed air quality data to a server. The server stores and optimizes the data through cross-calibration and makes the data available to persons who have purchased the monitoring devices and who wish to share the data in a social network. | 02-14-2013 |
| 20130035333 | USE OF CINNABARINIC ACID AS A MODULATOR OF IMMUNE RESPONSES IN AUTOIMMUNE DISORDERS - The present invention provides compounds and methods for preventing and treating an immune disorder in a subject. | 02-07-2013 |
| 20130035325 | KINASE INHIBITORS - Methods of inhibiting kinases using kinase inhibitors having olefin moieties are disclosed. | 02-07-2013 |
| 20130034576 | NOVEL ADENOVIRUS ISOLATED FROM TITI MONKEYS - Provided is a Titi Monkey Adenovirus (TMAdV) that can infect both human and non-human primates. Further provided are nucleic acid sequences, proteins, expression vectors and host cells, anti-TMAdV antibodies, vaccines, compositions, methods of detecting TMAdV, methods for assaying for anti-TMAdV compounds, and methods for treating or preventing a TMAdV infection. | 02-07-2013 |
| 20130034555 | EPITHELIAL MEMBRANE PROTEIN 2 (EMP2) BINDING REAGENTS AND THEIR THERAPEUTIC USES IN OCULAR DISEASES - A method is disclosed for treating diseases or disorders of the eye involving undesired expression of vascular endothelial growth factor (VEGF) by administration of endothelial membrane protein 2 (EMP2) inhibitor. The present invention relates to the direct treatment of macular degeneration, particularly age-related macular degeneration (AMD), by administering an EMP2 inhibitor intraocularly or systemically. | 02-07-2013 |
| 20130034501 | DIARYLHYDANTOIN COMPOUNDS - The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone lefiactory prostate cancer. | 02-07-2013 |
| 20130030499 | METHOD FOR DEEP BRAIN STIMULATION TARGETING BASED ON BRAIN CONNECTIVITY - Due to the lack of internal anatomic detail with traditional magnetic resonance imaging, preoperative stereotactic planning for the treatment of tremor usually relies on indirect targeting based on atlas-derived coordinates. To overcome such disadvantages, a method is provided that allows for deep brain stimulation targeting based on brain connectivity. For example, probabilistic tractography-based thalamic segmentation for deep brain stimulator (DBS) targeting is suitable for the treatment of tremor. | 01-31-2013 |
| 20130030368 | SYSTEMS, DEVICES AND METHODS FOR CRAINIAL IMPLANTATION OF A NEUROMODULATION DEVICE - Described herein is an implantable device including: a housing including a connection opening defined therein, wherein the connection opening includes posts and slots and is configured to receive at least one connection associated with a neuromodulation device; a connection holding cap having posts, wherein the posts are configured to oppose the posts of the connection opening and wherein the connection holding cap is configured to receive the at least one connection associated with the neuromodulation device and configured to be operably connected to the connection opening by interconnecting the opposing posts after receiving the at least one connection associated with the neuromodulation device; a neuromodulation device holder operably connected to the device housing and configured to receive the neuromodulation device and secure the neuromodulation device within the device housing; and a cover operably connected to the device housing and configured to seal the device housing. Other embodiments are also described. | 01-31-2013 |
| 20130030027 | HEMI-PHORBOXAZOLE A DERIVATIVES AND METHODS OF THEIR USE - The present invention is directed to hemi phorboxazole A: and its stereoisomers, as well as derivatives of hemi phorboxazole A of formula I: wherein ring A is aryl or a 5- or 6-membered heteroaryl optionally substituted with one or more of halogen, —OH, or —C | 01-31-2013 |
| 20130029940 | PHOSPHONATES WITH REDUCED TOXICITY FOR TREATMENT OF VIRAL INFECTIONS - There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are also provided methods of using the disclosed compounds for inhibiting viral RNA-dependent RNA polymerase, inhibiting viral reverse transcriptase, inhibiting replication of virus, including hepatitis C virus or a human retrovirus, and treating a subject infected with a virus, including hepatitis C virus or a human retrovirus. | 01-31-2013 |
| 20130029386 | COMPOSITIONS AND METHODS FOR THE PRODUCTION OF L-HOMOALANINE - Healthcare costs are a significant worldwide, with many patients being denied medications because of their high prices. One approach to addressing this problem involves the biosynthesis of chiral drug intermediates, an environmentally friendly solution that can be used to generate pharmaceuticals at much lower costs than conventional techniques. In this context, embodiments of the invention comprise methods and materials designed to allow microorganisms to biosynthesize the nonnatural amino acid L-homoalanine. As is known in the art, L-homoalanine is a chiral precursor of a variety of pharmaceutically valuable compounds including the anticonvulsant medications levetiracetam (sold under the trade name Keppra®) and brivaracetam, as well as ethambutol, a bacteriostatic antimycobacterial drug used to treat tuberculosis. Consequently, embodiments of the invention can be used in low cost, environmentally friendly processes to generate these and other valuable compounds. | 01-31-2013 |
| 20130029332 | COMPOSITIONS AND METHODS FOR DETECTING NOONAN SYNDROME - Diagnostic and therapeutic applications for Noonan Syndrome are described. The diagnostic and therapeutic applications are based on certain mutations in a RAS-specific guanine nucleotide exchange factor gene SOS1 or its expression product. The diagnostic and therapeutic applications are also based on certain mutations in a serine/threonine protein kinase gen RAF1 or its expression product thereof. Also described are nucleotide sequences, amino acid sequences, probes, and primers related to RAF1 or SOS1, and variants thereof, as well as host cells expressing such variants. | 01-31-2013 |
| 20130028966 | Broad Spectrum Antiviral and Antiparasitic Agents - The invention provides compounds represented by the formulae: (I) and (II) where the compounds are useful in treating, for example, viral and/or parasitic infections. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds. | 01-31-2013 |
| 20130028963 | Forming an Artificial Cell with controlled membrane composition, asymmetry, and contents - The present invention provides a vesicle having a unilamellar bilayer including a lipid and a second bilayer component selected from a membrane protein or a functionalized lipid. The vesicle also includes a component encapsulated by the unilamellar bilayer, wherein the encapsulated component includes a protein, a peptide, an enzyme, an oligonucleotide, or a polynucleotide. Also included are methods of making the vesicles of the present invention. | 01-31-2013 |
| 20130028962 | Triggered Cargo Release from Nanoparticle Stabilized Liposomes - Control of the fusion activity of liposomes by adsorbing biocompatible nanoparticles to the outer surface of phospholipid liposomes is disclosed. The biocompatible nanoparticles effectively prevent liposomes from fusing with one another. Release of cargo from the liposome is accomplished via trigger mechanisms that include pH triggers, pore forming toxing triggers and photosensitive triggers. Dermal drug delivery to treat a variety of skin diseases such as acne vulgaris and staph infections is contemplated. | 01-31-2013 |
| 20130028891 | Unconjugated Anti-TfR Antibodies and Compositions Thereof for the Treatment of Cancer - Disclosed herein are methods and compositions for treating cancer. In particular, the in vivo efficacy of unconjugated anti-TfR antibodies, such as ch128.1, are disclosed herein. | 01-31-2013 |
| 20130028812 | METHODS AND SYSTEMS FOR ON DEMAND DROPLET GENERATION AND IMPEDANCE BASED DETECTION - The present invention pertains to methods and systems for on demand droplet generation and impedance based detection. The microfluidic system can utilize an electrical sensor for detecting an electrical property of a fluid and for generating an electrical signal indicating a change in the electrical property of the fluid; a droplet generator coupled to the electrical sensor configured to generate the droplet from the fluid in response to the electrical signal from the electrical sensor; and a microfluidic channel coupled to the droplet generator for receiving the droplet. The method for generating droplets involves measuring an electrical property of the fluid, transmitting an electrical signal indicative of the electrical property, and forming the droplets from the fluid based on the electrical signal. | 01-31-2013 |
| 20130024118 | System and Method for Identifying Patterns in and/or Predicting Extreme Climate Events - A method and system are provided for medium-range probabilistic prediction of extreme temperature events. Extreme temperatures are measured according to how local temperature thresholds are exceeded on daily timescales to generate a local “Magnitude Index” (MI). A regional MI reflecting the historic temperature intensity, duration and spatial extent of extreme temperature events over all locations within the region is then computed. The regional MI is used to create a synoptic catalog for each of one or more pre-defined weather variables by testing the significance of leading modes in historic atmospheric variability across specified periods of time. Current or recent weather conditions are compared against the synoptic catalog to generate probabilistic predictions of extreme temperature events based the presence of synoptic precursors identified in historic patterns. | 01-24-2013 |
| 20130023765 | APPARATUS AND METHOD FOR QUANTITATIVE NONCONTACT IN VIVO FLUORESCENCE TOMOGRAPHY USING A PRIORI INFORMATION - An apparatus for providing an integrated tri-modality system includes a fluorescence tomography subsystem (FT), a diffuse optical tomography subsystem (DOT), and an x-ray tomography subsystem (XCT), where each subsystem is combined in the integrated tri-modality system to perform quantitative fluorescence tomography with the fluorescence tomography subsystem (FT) using multimodality imaging with the x-ray tomography subsystem (XCT) providing XCT anatomical information as structural a priori data to the integrated tri-modality system, while the diffuse optical tomography subsystem (DOT) provides optical background heterogeneity information from DOT measurements to the integrated tri-modality system as functional a priori data. A method includes using FT, DOT, and XCT in an integrated fashion wherein DOT data is acquired to recover the optical property of the whole medium to accurately describe photon propagation in tissue, where structural limitations are derived from XCT, and accurate fluorescence concentration and lifetime parameters are recovered to form an accurate image. | 01-24-2013 |
| 20130023402 | Preparation of Functionalized Zeolitic Frameworks - The disclosure provides zeolitic frameworks for gas separation, gas storage, catalysis and sensors. More particularly the disclosure provides zeolitic frameworks (ZIFs). The ZIF of the disclosure comprises any number of transition metals or a homogenous transition metal composition. | 01-24-2013 |
| 20130023015 | Useful halophilic, thermostable and ionic liquids tolerant cellulases - The present invention provides for an isolated or recombinant polypeptide comprising an amino acid sequence having at least 70% identity with the amino acid sequence of a | 01-24-2013 |
| 20130022873 | HIGH-POWER NANOCOMPOSITE CATHODES FOR LITHIUM ION BATTERIES - A method of growing electrochemically active materials in situ within a dispersed conductive matrix to yield nanocomposite cathodes or anodes for electrochemical devices, such as lithium-ion batteries. The method involves an in situ formation of a precursor of the electrochemically active materials within the dispersed conductive matrix followed by a chemical reaction to subsequently produce the nanocomposite cathodes or anodes, wherein: the electrochemically active materials comprise nanocrystalline or microcrystalline electrochemically active metal oxides, metal phosphates or other electrochemically active materials; the dispersed conductive matrix forms an interconnected percolation network of electrically conductive filaments or particles, such as carbon nanotubes; and the nanocomposite cathodes or anodes comprise a homogeneous distribution of the electrochemically active materials within the dispersed conductive matrix. | 01-24-2013 |
| 20130022614 | IgE ANTIBODIES FOR THE TREATMENT OF CANCER - The present invention provides monoclonal IgE antibodies comprising Fc epsilon (ε) constant regions and variable regions comprising at least one antigen binding region specific for binding a single epitope of a circulating, tumor-associated antigen (TAA) that is not a cell surface antigen wherein the epitope of the targeted antigen is not highly repetitive or is a non-repetitive epitope. The IgE antibodies of the invention are useful in the treatment of cancer associated with the tumor antigen. In one embodiment the TAA is prostate-specific antigen (PSA). | 01-24-2013 |
| 20130022593 | METHODS OF DIAGNOSING ENDOMETRIOSIS - The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with endometriosis. Similarly, these markers can be used to diagnose reduced fertility in a patient with endometriosis or to provide a prognosis for a fertility trial in a patient suffering from endometriosis. The present invention also provides methods of identifying a compound for treating or preventing endometriosis. Finally, the present invention provides kits for the diagnosis or prognosis of endometriosis. | 01-24-2013 |
| 20130022072 | III-V PHOTONIC INTEGRATION ON SILICON - Photonic integrated circuits on silicon are disclosed. By bonding a wafer of III-V material as an active region to silicon and removing the substrate, the lasers, amplifiers, modulators, and other devices can be processed using standard photolithographic techniques on the silicon substrate. The coupling between the silicon waveguide and the III-V gain region allows for integration of low threshold lasers, tunable lasers, and other photonic integrated circuits with Complimentary Metal Oxide Semiconductor (CMOS) integrated circuits. | 01-24-2013 |
| 20130020602 | TRANSPARENT LIGHT EMITTING DIODES - A transparent light emitting diode (LED) includes a plurality of III-nitride layers, including an active region that emits light, wherein all of the layers except for the active region are transparent for an emission wavelength of the light, such that the light is extracted effectively through all of the layers and in multiple directions through the layers. Moreover, the surface of one or more of the III-nitride layers may be roughened, textured, patterned or shaped to enhance light extraction. | 01-24-2013 |
| 20130020556 | HYBRID SILICON EVANESCENT PHOTODETECTORS - Photodetectors and integrated circuits including photodetectors are disclosed. A photodetector in accordance with the present invention comprises a silicon-on-insulator (SOI) structure resident on a first substrate, the SOI structure comprising a passive waveguide, and a III-V structure bonded to the SOI structure, the III-V structure comprising a quantum well region, a hybrid waveguide, coupled to the quantum well region and the SOI structure adjacent to the passive waveguide, and a mesa, coupled to the quantum well region, wherein when light passes through the hybrid waveguide, the quantum well region detects the light and generates current based on the light detected. | 01-24-2013 |
| 20130020495 | Compact High Precision Adjustable Beam Defining Aperture - The present invention provides an adjustable aperture for limiting the dimension of a beam of energy. In an exemplary embodiment, the aperture includes (1) at least one piezoelectric bender, where a fixed end of the bender is attached to a common support structure via a first attachment and where a movable end of the bender is movable in response to an actuating voltage applied to the bender and (2) at least one blade attached to the movable end of the bender via a second attachment such that the blade is capable of impinging upon the beam. In an exemplary embodiment, the beam of energy is electromagnetic radiation. In an exemplary embodiment, the beam of energy is X-rays. | 01-24-2013 |
| 20130017232 | SYNTHETIC BONE GRAFTS - The disclosure provides Bone-mimetic mineral/polymer composite materials useful for formation of artificial bone grafts and for bone tissue engineering. The disclosure provides a hydrogels, cryogels and macroporous compositions modified with varying lengths of anionic pendant side chains (CH | 01-17-2013 |
| 20130016808 | APPARATUS AND METHODS FOR DETERMINATION OF THE HALF VALUE LAYER OF X-RAY BEAMS - Described is an apparatus for use in HVL measurement as well as methods of making measurements. One version of the apparatus is a cage structure having a central axis and a central opening defined by a filter encircling the central axis, with the filter having a thickness that varies peripherally around said central axis. The filter can be formed from multiple spaced-apart plates having varying thicknesses or can be formed from a cylinder having a continuously increasing thickness. | 01-17-2013 |
| 20130015760 | INTERDIGITATED MULTIPLE PIXEL ARRAYS OF LIGHT-EMITTING DEVICES - The present invention discloses a plurality of interdigitated pixels arranged in an array, having a very low series-resistances with improved current spreading and improved heat-sinking Each pixel is a square with sides of dimension 1. The series resistance is minimized by increasing the perimeter of an active region for the pixels. The series resistance is also minimized by shrinking the space between a mesa and n-contact for each pixel. | 01-17-2013 |
| 20130015560 | GROWTH OF BULK GROUP-III NITRIDE CRYSTALS AFTER COATING THEM WITH A GROUP-III METAL AND AN ALKALI METAL - A method of producing a Group-III nitride crystal by coating at least one surface of the seed with a thin wetting layer or film comprised of one or more Group-III and alkali metals. | 01-17-2013 |
| 20130015492 | OPTO-ELECTRONIC AND ELECTRONIC DEVICES USING AN N-FACE OR M-PLANE GALLIUM NITRIDE SUBSTRATE PREPARED VIA AMMONOTHERMAL GROWTH - A method for growing III-V nitride films having an N-face or M-plane using an ammonothermal growth technique. The method comprises using an autoclave, heating the autoclave, and introducing ammonia into the autoclave to produce smooth N-face or M-plane Gallium Nitride films and bulk GaN. | 01-17-2013 |
| 20130015429 | ALL GRAPHENE FLASH MEMORY DEVICEAANM Hong; Augustin J.AACI Los AngelesAAST CAAACO USAAGP Hong; Augustin J. Los Angeles CA USAANM Kim; Ji-YoungAACI Los AngelesAAST CAAACO USAAGP Kim; Ji-Young Los Angeles CA USAANM Wang; Kang-LungAACI Santa MonicaAAST CAAACO USAAGP Wang; Kang-Lung Santa Monica CA US - A Graphene Flash Memory (GFM) device is disclosed. In general, the GFM device includes a number of memory cells, where each memory cell includes a graphene channel, a graphene storage layer, and a graphene electrode. In one embodiment, by using a graphene channel, graphene storage layer, and graphene electrode, the memory cells of the GFM device are enabled to be scaled down much more than memory cells of a conventional flash memory device. More specifically, in one embodiment, the GFM device has a feature size less than 25 nanometers, less than or equal to 20 nanometers, less than or equal to 15 nanometers, less than or equal to 10 nanometers, or less than or equal to 5 nanometers. | 01-17-2013 |
| 20120330291 | NONLINEAR OPTICAL PHOTODYNAMIC THERAPY (NLO-PDT) OF THE CORNEA - The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. | 12-27-2012 |
| 20120330131 | MR COMPATIBLE COMPRESSION BASED NUCLEAR IMAGING SYSTEM FOR BREAST CANCER - An apparatus combines magnetic resonance (MR) and nuclear imaging of human breast for cancer diagnosis. An MRI system including an MR breast RF coil is combined with a nuclear imaging system having a detector disposed or disposable within the MR breast RF coil arranged and configured for the performance of simultaneous or sequential coregistered breast MRI and nuclear imaging. A selectively controlled compression mechanism for lightly compresses the breast being imaged. The remotely controlled compression mechanism is integrated with the MR breast RF coil. | 12-27-2012 |
| 20120329878 | PHENOTYPING TUMOR-INFILTRATING LEUKOCYTES - The present disclosure relates to an immune signature of tumor infiltrating leukocytes. In particular, the disclosure provides methods and kits for determining the immune signature of tumor infiltrating leukocytes for use in assessing risk of cancer recurrence and long term survival, and for developing a treatment regimen for a cancer patient. | 12-27-2012 |
| 20120329678 | Method for Making Mate-Pair Libraries - The present disclosure provides methods for generating mate-pair libraries using a recombinase/recombination site system. The method allows for increased insert size, improved efficiency and simplicity of the steps involved, and improved data generation. Mate-pair libraries are helpful in providing positional information for the assembly of sequence data from short read sequencing platforms. The disclosure also embodies the mate-pair libraries as generated from these methods. | 12-27-2012 |
| 20120329663 | 14-3-3 sigma as a Biomarker of Basal Cancer - Methods and compositions for using 14-3-3sigma gene and protein as a highly sensitive and specific basal breast cancer biomarker, which when present, correlates with metastasis and poor outcome in independent patient cohorts. Methods and compositions for targeting 14-3-3sigma-regulated actin cytoskeletal interactions, activity and function may benefit patients having the basal-like breast cancer subtype. | 12-27-2012 |
| 20120329174 | LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES - The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands. | 12-27-2012 |
| 20120329085 | FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES - The invention provides reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells. | 12-27-2012 |
| 20120328628 | ANTIBODIES TO CONFORMATIONALLY TRAPPED PROTEINS - The present invention provides methods for generating antibodies to specific conformations of proteins. The conformation specific antibodies of the invention can be put to a variety of uses including diagnosis and treatment of diseases and for screening for compounds that induce conformational changes in proteins upon binding. | 12-27-2012 |
| 20120328604 | METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH AVB5 INTEGRIN - The present invention provides compositions and methods for treating and preventing disease associated with αvβ5 integrin by blocking binding to αvβ5 integrin. In particular, antibodies specific for αvβ5 integrin are useful for preventing, treating, and reversing sepsis. | 12-27-2012 |
| 20120328505 | Nanostructured Transition Metal Oxides Useful for Water Oxidation Catalysis - The present invention provides for a composition comprising a nanostructured transition metal oxide capable of oxidizing two H | 12-27-2012 |
| 20120328434 | INTEGRATED WIND TURBINE - An integrated wind turbine. Each turbine blade has a flexible skin. Openings in the leading edge lead to one or more inflation chambers for ram air inflation during operation. A pivotal connection with the support post allows the plurality of turbine blades to yaw such that the rotor plane remains substantially perpendicular to the wind direction. The wind turbine may also include self-deploying drag vanes that extend away from the flexible skin when the wind speed is greater than the speed of the airfoil. | 12-27-2012 |
| 20120328240 | METAMATERIAL-BASED OPTICAL LENSES - Devices based on metamaterial structures to guide and manipulate light, other electromagnetic radiation and acoustic waves. For example, a lens can include a metamaterial structure comprising nano structures of metallic and dielectric materials; and a plasmonic waveguide coupler formed over the metamaterial structure for coupling electromagnetic radiation to or from metamaterial structure. The metamaterial structure has an anisotropic structure and the plasmonic waveguide coupler is structured to include metal and non-metal parts to support surface plasmon polaritons and to cause different phase delays at different locations of an interface with the metamaterial structure in a way that the metamaterial structure and the plasmonic waveguide coupler effect a lens for performing a Fourier transform of the electromagnetic radiation coupled between the metamaterial structure and the plasmonic waveguide coupler. | 12-27-2012 |
| 20120325678 | STRUCTURES AND FABRICATION TECHNIQUES FOR SOLID STATE ELECTROCHEMICAL DEVICES - Porous substrates and associated structures for solid-state electrochemical devices, such as solid-oxide fuel cells (SOFCs), are low-cost, mechanically strong and highly electronically conductive. Some preferred structures have a thin layer of an electrocatalytically active material (e.g., Ni-YSZ) coating a porous high-strength alloy support (e.g., SS-430) to form a porous SOFC fuel electrode. Electrode/electrolyte structures can be formed by co-firing or constrained sintering processes. | 12-27-2012 |
| 20120325665 | MICROFLUIDIC DEVICES WITH FLEXIBLE OPTICALLY TRANSPARENT ELECTRODES - Microfluidic devices in which electrokinetic mechanisms move droplets of a liquid or particles in a liquid are described. The devices include at least one electrode that is optically transparent and/or flexible. | 12-27-2012 |
| 20120323102 | NEURAL PROBE ARRAY AND METHOD OF USE - A neural probe device includes a housing configured to receive a nerve fiber of a subject and an anchor disposed within the housing and configured to fix the nerve fiber relative to the housing. The device further includes a plurality of actuatable, moveable electrodes disposed in the housing along a length of the nerve fiber, each moveable electrode comprising a plurality of projections containing one or more electrodes thereon, wherein actuation of the moveable electrode causes the moveable electrode to move generally transverse to a long axis of the nerve fiber and penetrate the nerve fiber with the plurality of projections. The device is also optionally configured to inject a growth factor into the nerve fiber to maintain the viability of the nerve fiber. | 12-20-2012 |
| 20120322814 | METHODS OF INHIBITING IRE1 - Disclosed herein are, inter alia, methods for inhibiting Ire1 activity. | 12-20-2012 |
| 20120322674 | DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER - This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal. | 12-20-2012 |
| 20120322668 | ASSESSMENT OF SOLID TUMOR BURDEN - The present disclosure is directed toward measurement of expression of one or both of an activating Natural Killer (NK) cell receptor and its ligand(s) on peripheral blood cells as a means to assess solid tumor burden. In particular, the present disclosure provides tools for assessing cancer recurrence or risk thereof following reduction of a solid tumor, and for developing a treatment regime for a cancer patient. | 12-20-2012 |
| 20120321611 | Replenishment and Enrichment of Ocular Surface Lubrication - An ophthalmic composition, and methods of use thereof, including for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface or for the treatment or care of ophthalmic devices. The ophthalmic composition comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The ophthalmic composition may also comprise one or more ophthalmically acceptable agents. | 12-20-2012 |
| 20120319997 | SCALABLE DISTRIBUTED/COOPERATIVE/COLLABORATIVE PARADIGM FOR MULTI-USER INTERACTION WITH PROJECTION-BASED DISPLAY WALLS - A method of distributed/cooperative/collaborative gesture management may comprise queuing actions of gestures as the gestures move across a display, processing the actions of each of the gestures by a projector in which the projector's display is close to a gesture, sending an anticipatory action message that one of the gestures is predicted to enter a display region of a projector, processing the actions of one of the gestures by a projector in which the projector's display is close to the one of the gestures, and in response to the one of the gestures being in an overlapping display projected by overlapping projectors, the actions of the one of the gestures are processed by the overlapping projector with the smallest identifier. | 12-20-2012 |
| 20120319127 | CURRENT APERTURE VERTICAL ELECTRON TRANSISTORS WITH AMMONIA MOLECULAR BEAM EPITAXY GROWN P-TYPE GALLIUM NITRIDE AS A CURRENT BLOCKING LAYER - A current aperture vertical electron transistor (CAVET) with ammonia (NH | 12-20-2012 |
| 20120316347 | METAL COLLOIDS WITH ACCESSIBLE METAL SURFACES - The invention provides complexes in which ligands (e.g., calixarene-related compounds) are coordinated to a metal colloid, e.g. a gold colloid. In exemplary embodiments, two or more ligands complexed to the metal colloid are larger than the metal colloid, thus providing an accessible metal center. The complexes can be immobilized on a substrate. The complexes of the invention are useful as tunable and highly robust isolated metal colloids that find use in binding of molecules and catalysis of chemical reactions. | 12-13-2012 |
| 20120316076 | BIOMARKERS FOR THE DIAGNOSIS OF LACUNAR STROKE - This invention provides gene expression profiles useful for diagnosing lacunar stroke and for distinguishing lacunar stroke from non-lacunar stroke. | 12-13-2012 |
| 20120315695 | Recovery of sugars from ionic liquid biomass liquor by solvent extraction - The present invention provides for a composition comprising a solution comprising (a) an ionic liquid (IL) or ionic liquid-aqueous (ILA) phase and (b) an organic phase, wherein the solution comprises a sugar and a boronic acid. The present invention also provides for a method of removing a sugar from a solution, comprising: (a) providing a solution comprising (i) an IL or ILA phase and (ii) an organic phase, wherein the solution comprises an IL, a sugar and a boronic acid; (b) contacting the sugar with the boronic acid to form a sugar-boronic acid complex, (c) separating the organic phase and the aqueous phase, wherein the organic phase contains the sugar-boronic acid complex, and optionally (d) separating the sugar from the organic phase. | 12-13-2012 |
| 20120315680 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS - The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. | 12-13-2012 |
| 20120313077 | HIGH EMISSION POWER AND LOW EFFICIENCY DROOP SEMIPOLAR BLUE LIGHT EMITTING DIODES - High emission power and low efficiency droop semipolar blue light emitting diodes (LEDs). | 12-13-2012 |
| 20120313076 | LOW DROOP LIGHT EMITTING DIODE STRUCTURE ON GALLIUM NITRIDE SEMIPOLAR SUBSTRATES - A light emitting diode structure of (Al,Ga,In)N thin films grown on a gallium nitride (GaN) semipolar substrate by metal organic chemical vapor deposition (MOCVD) that exhibits reduced droop. The device structure includes a quantum well (QW) active region of two or more periods, n-type superlattice layers (n-SLs) located below the QW active region, and p-type superlattice layers (p-SLs) above the QW active region. The present invention also encompasses a method of fabricating such a device. | 12-13-2012 |
| 20120309904 | Direct Hierarchical Assembly of Nanoparticles - The present invention provides hierarchical assemblies of a block copolymer, a bifunctional linking compound and a nanoparticle. The block copolymers form one micro-domain and the nanoparticles another micro-domain. | 12-06-2012 |
| 20120309730 | OXYSTEROLS THAT ACTIVATE LIVER X RECEPTOR SIGNALING AND INHIBIT HEDGEHOG SIGNALING - This invention relates, e.g., to compositions comprising oxysterol compounds represented by Formula I or Formula II, e.g., comprising one or more of Oxy 16, Oxy 22, Oxy30, Oxy 31, Oxy35, Oxy37, Oxy43, Oxy44, Oxy45 or Oxy47. The compounds are shown to be Hedgehog pathway inhibiting, and to act as agonists for liver X receptor (LXR). Also disclosed are methods of using compositions of the invention to inhibit Hedgehog signaling effects, such as cell proliferation, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention. | 12-06-2012 |
| 20120309693 | Methods to Accelerate Tissue and Wound Healing Rates and Reduce Swelling and Scar Formation - The present disclosure serves to reduce the healing time of tissue wounds, including those formed during surgery, whether necessary or elective (including cosmetic surgery), by providing a therapeutic dose of a pancreatic enzyme inhibitor. | 12-06-2012 |
| 20120305937 | SEMICONDUCTOR LIGHT-EMITTING DEVICE - A semiconductor light-emitting diode, and method of fabricating same, wherein an indium (In)-containing light-emitting layer, as well as subsequent device layers, is deposited on a textured surface. The resulting device is a phosphor-free white light source. | 12-06-2012 |
| 20120305400 | MONOLITHICALLY FORMED EWOD DEVICE AND METHOD OF MAKING THE SAME - A monolithic fabrication method of parallel-plate electrowetting-on-dielectric (EWOD) chips for digital microfluidics of picoliter droplets is disclosed. Instead of assembling a second substrate to form a top plate, the top plate is generated in situ as a thin-film membrane that forms a monolithic cavity having a gap height on the order of micrometers with excellent accuracy and uniformity. The membrane is embedded with EWOD driving electrodes and confines droplets against the device substrate to perform digital microfluidic operations. Two main attributes of the monolithic architecture that distinguish it from tradition methods are: (i) it enables excellent control of droplet dimensions down to the micrometer scale, and (ii) it does not require the typical alignment and assembly steps of the two plates. | 12-06-2012 |
| 20120302603 | AMYLOID BINDING AGENTS - There are provided compounds and methods for the detection and treatment of amyloid deposits and diseases and disorders characterized by amyloid deposits including Alzheimer's disease and related amyloid-based neurodegenerative disorders. | 11-29-2012 |
| 20120302451 | COMPOSITIONS AND METHODS FOR GENE SIGNATURE-BASED CHEMICAL SCREENING - The invention provides products of manufacture for screening for compositions that can modify a cell's gene expression profile, and methods for making and using them. In one embodiment, the invention provides products of manufacture and methods comprising a high content, high throughput screening for a composition (e.g., chemicals, small molecules) that can modify a cell's physiology based on the composition's ability to modify the cell's gene expression signature. | 11-29-2012 |
| 20120302437 | Nanocrystal Assembly for Tandem Catalysis - The present invention provides a nanocrystal tandem catalyst comprising at least two metal-metal oxide interfaces for the catalysis of sequential reactions. One embodiment utilizes a nanocrystal bilayer structure formed by assembling sub- | 11-29-2012 |
| 20120301953 | GRAPHENE NANOMESH AND METHOD OF MAKING THE SAME - A graphene nanomesh includes a sheet of graphene having a plurality of periodically arranged apertures, wherein the plurality of apertures have a substantially uniform periodicity and substantially uniform neck width. The graphene nanomesh can open up a large band gap in a sheet of graphene to create a semiconducting thin film. The periodicity and neck width of the apertures formed in the graphene nanomesh may be tuned to alter the electrical properties of the graphene nanomesh. The graphene nanomesh is prepared with block copolymer lithography. Graphene nanomesh field-effect transistors (FETs) can support currents nearly 100 times greater than individual graphene nanoribbon devices and the on-off ratio, which is comparable with values achieved in nanoribbon devices, can be tuned by varying the neck width. The graphene nanomesh may also be incorporated into FET-type sensor devices. | 11-29-2012 |
| 20120301948 | Novel method of acid hydrolysis of biomass and the recovery of sugars thereof by solvent extraction - The present invention provides for a method of hydrolyzing a cellulose, hemicellulose, or ligno-cellulose comprising: (a) contacting (i) an ionic liquid (IL) or ionic liquid-aqueous (ILA) phase comprising cellulose, hemicellulose, or ligno-cellulose, or a mixture thereof, and (ii) an acid, such that the cellulose, hemicellulose, or ligno-cellulose is hydrolyzed into sugar, and (b) optionally adding water to the IL or ILA phase wherein the proportion of water in the IL or ILA phase does not exceed about 60% by weight. The present invention also provides for a method of recovering a sugar comprising contacting an IL or ILA phase and an organic phase comprising an organic acid. | 11-29-2012 |
| 20120301839 | METHOD AND APPARATUS FOR THE ASSESSMENT OF PULPAL VITALITY USING LASER SPECKLE IMAGING - The invention includes a noninvasive method for characterizing dental pulpal vitality of a tooth including the steps of irradiating the tooth with at least partially coherent light, and speckle imaging to provide quantitative feedback to an end user of pulpal blood flow in the tooth, and the tangible records made by such a method. The invention also includes an apparatus for noninvasively characterizing dental pulpal vitality of a tooth comprising a source of at least partially coherent light for irradiating the tooth characterized by a speckle pattern, optics for directing the at least partially coherent light onto the tooth, including a corresponding pulpal cavity within the tooth, a detector for detecting transmission of the at least partially coherent light through the tooth, and a processor coupled to the detector speckle imaging to provide a quantitative feedback of pulpal blood flow in the tooth. | 11-29-2012 |
| 20120300364 | HIERARCHIALLY POROUS CARBON PARTICLES FOR ELECTROCHEMICAL APPLICATIONS - Hierarchically porous graphitic carbon particles are prepared by an aerosol process using a aqueous solution of a carbon precursor compound in which different sized particles or clusters of silicon oxide species are dispersed. The aerosol is heated to evaporate the solvent. The solid residue is carbonized and non-carbon species removed to obtain small porous particles of graphitic carbon. The interconnected, different size pores in the small carbon particles make them very useful as electrode materials in electrochemical devices, such as supercapcitors, in which efficient ion transport through the pores or the particles is required. | 11-29-2012 |
| 20120298512 | SMALL VOLUME LIQUID MANIPULATION, METHOD, APPARATUS AND PROCESS - An apparatus, a method and a process to achieve manipulation of particles and/or solutions through the use of electrokinetic properties are disclosed. The manipulation is performed using a disposable device positioned on top of a stage for purposes of powering the electrodes. The fluidic solution is brought into contact with the active part of the device and then manipulated. | 11-29-2012 |
| 20120296092 | Molecular Cobalt Pentapyridine Catalysts for Generating Hydrogen from Water - A composition of matter suitable for the generation of hydrogen from water is described, the positively charged cation of the composition including the moiety of the general formula. [(PY5Me | 11-22-2012 |
| 20120295975 | METHODS OF TREATING INFLAMMATORY CONDITIONS - The present invention provides methods of treating a β-arrestin2 mediated and/or GPR120 mediated response in a subject. The β-arrestin2 mediated and/or GPR120 mediated response can be inflammation, including diabetes, inflammation associated with obesity and obesity. The methods can comprise administering to a subject a therapeutically effective amount of a compound predicted to bind a β-arrestin2 molecule and/or GPR120, wherein the compound selectively activates a β-arrestin2-dependent signaling pathway of GPR120. | 11-22-2012 |
| 20120295944 | TREATMENT OF HYPERPROLIFERATIVE DISORDERS WITH DIARYLHYDANTOIN COMPOUNDS - The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer. | 11-22-2012 |
