| The Queen's Medical Center Patent applications |
| Patent application number | Title | Published |
|---|
| 20110230368 | High Throughput Assays for TRPM7 - The present invention provides high throughput assays for TRPM7 activity. The present invention encompasses methods and compositions for screening a sample for inhibitors of TRPM7, including methods and compositions for competitive high throughput assays. | 09-22-2011 |
| 20110028725 | Preparation and Use of Alkylating Agents - The present disclosure provides methods of synthesizing alkylating agents and methods of use. | 02-03-2011 |
| 20090209435 | Methods of screening for TRPM4b modulators - The invention relates, in part, to methods useful in identifying molecules, that bind TRPM4b, which modulate TRPM4b ion channel activity, and/or which alter expression of TRPM4b within cells. The TRPM4b channels as described herein contain TRPM4b polypeptides, which are in turn encoded by TRPM4b nucleic acids. The ion channels described herein are preferably formed in HEK-293 cells from one or more novel TRPM4b polypeptides, which exhibit one or more of the unique TRPM4b properties described herein. | 08-20-2009 |
| 20090098546 | Methods of Screening for LTRPC7 Modulators - The present invention relates to the identification and isolation of a novel family of ATP regulated calcium transmembrane channel polypeptides designated herein as “LTRPC7” (Long Transient Receptor Potential Channel). Channels comprising these polypeptides close in response to concentrations of cytoplasmic ATP in the millimolar range, are subject to inhibition by high intracellular levels of calcium and/or magnesium, and do not respond to depletion or reduction in intracellular calcium stores. The invention further relates to the methods of utilizing LTRPC7 for binding, and the methods for modulating LTRPC7 activity and for measuring LTRPC2 permeability. The invention further relates to the methods of modulating expression of LTRPC7. | 04-16-2009 |
| 20090053753 | FUNCTIONAL IDENTIFICATION OF PROTEINS UNDERLYING Icrac ACTIVITY IN A CELL - The invention provides methods and compositions for determining the identity of CRACM homologs underlying Icrac activity in cells. | 02-26-2009 |
| 20090023177 | ASSAYS AND METHODS FOR DETERMINING STIM2 ACTIVITY - The present invention provides assays and methods for determining levels of STIM2 activity, thus providing tools for the characterization and study of the regulation of intracellular calcium levels. | 01-22-2009 |
| 20080294289 | Preparation and Use of Alkylating Agents - The present disclosure provides methods of synthesizing alkylating agents and methods of use. | 11-27-2008 |
