| THE OHIO STATE UNIVERSITY Patent applications |
| Patent application number | Title | Published |
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| 20120126920 | LAMINATE COMPOSITE AND METHOD FOR MAKING SAME - An organic-based magnet is formed by molecular layer deposition (MLD) of a first compound and MLD of a second compound. The first or second compound containing a metal-containing compound. The first and second compounds being reactive with each other to form a first layer organic-based magnet. A laminate composite includes a first monolayer including a metal bonded to a magnet forming organic compound. A second monolayer may be in direct contact with the first monolayer. One of the first monolayer and the second monolayer having an induced magnetization when exposed to a magnetic field. A device includes the laminate composite and a nonmagnetic film thereon. A method of making an organic magnet on a substrate in a vacuum chamber includes depositing a first layer of metal-containing compound on the substrate by MLD. | 05-24-2012 |
| 20120116307 | DIFFUSION DELIVERY SYSTEMS AND METHODS OF FABRICATION - The invention generally relates to diffusion delivery systems and more particularly to high precision nanoengineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems. | 05-10-2012 |
| 20120103949 | LASER-INDUCED METALLURGICAL BONDING DRIVEN WITHOUT CONTACT - A laser, aimed at a flyer plate tab, causes optical energy to be directed at the tab, specifically, at a top surface thereof. Energy impacting the tab accelerates the tab into an impact with a target sheet in a time on the order of about 10 | 05-03-2012 |
| 20120100068 | Anti-CD74 Immunoconjugates and Methods of Use - Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions. | 04-26-2012 |
| 20120085353 | JOINT STABILITY ARRANGEMENT AND METHOD - The stability of an animal joint, especially a knee, is assessed with an arrangement having track arranged about perpendicular to the axis of the distal portion; a cart slidably engaged to the track; a fork positioned on the cart; a support adapted to receive the distal linear portion, the support connected to the fork; a lever arm connected to the support, the lever arm positioned to rotate the support about the axis of the distal portion; and at least one instrumented handle, the instrumented handle detachably engages at least one of the cart and the lever arm. In some embodiments, the fork can rotate freely on the cart. Additionally, in various embodiments, the cart may be selectively locked at a position along the length of the track. In various embodiments, the arrangement further comprises: a bracket rigidly attached to the distal portion and positioned between the support and the joint; and the at least one instrumented handle detachably engages the bracket. | 04-12-2012 |
| 20120083684 | DIGITAL DISTANCE MEASURER FOR NERVE CONDUCTION STUDIES - Nerve conduction studies (NCS) are used to diagnose many types of disorders and are being employed more and more frequently. Current methods for distance measurement during a NCS are manual and often time consuming and vulnerable to considerable error. A device and system for electronically measuring distance during a NCS and automatically transferring the data is disclosed. In one embodiment, the device incorporates a contact wheel to travel across the surface of the subject's skin to measure the applicable distance. | 04-05-2012 |
| 20120071045 | MARINE PROPULSION SYSTEM - A marine propulsion system comprising, in one embodiment: a fuel-filled tank; an air compressor that generates compressed air; an engine that receives fuel from the tank, wherein the air compressor is powered by the engine; and at least one hot gas generator that receives compressed air from the air compressor, the hot gas generator comprising: (a) a combustion chamber having an inlet and an outlet, the compressed air injected into the combustion chamber at the inlet, the combustion chamber adapted to produce hot gas; (b) an injection nozzle that receives fuel from the tank, the injection nozzle positioned proximate to the inlet of the combustion chamber, the injection nozzle adapted to spray the fuel into the combustion chamber; and (c) an exhaust Coanda nozzle positioned at the outlet of the combustion chamber through which the hot gas produced in the combustion chamber is discharged from the hot gas generator. | 03-22-2012 |
| 20120035457 | ELECTROMAGNETIC SYSTEM AND METHOD - Differences of electromagnetic (EM) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying EM field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. In some aspects, a change in phase shift between the voltage in a receiver coil and the voltage in a driver coil provide a direct and immediate indication of differences in EM properties of specimens. | 02-09-2012 |
| 20120027753 | MicroRNAs in Never-Smokers and Related Materials and Methods - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer in never-smokers. The invention also provides methods of identifying anti-lung cancer agents. | 02-02-2012 |
| 20120014857 | METHODS FOR SYNTHESIZING AMMONIA BORANE - Methods of synthesizing ammonia borane are provided. The methods comprise reacting at least one amine borane with ammonia such that ammonia borane is produced. Ammonia borane has a chemical formula of NH | 01-19-2012 |
| 20110313675 | RAPID DIAGNOSIS OF A DISEASE CONDITION USING INFRARED SPECTROSCOPY - Reliable and rapid diagnostic methods for many functional syndromes (FS) such as Bladder Pain Syndrome/Interstitial Cystitis (IC) are not available. Exemplary embodiments include rapid and accurate methods for diagnosing FS in humans and other mammals using infrared microspectroscopy (IRMS). Exemplary methods utilize Soft Independent Modeling by Class Analogy (SIMCA) to create classification models. Exemplary methods utilize classification models to categorize a subject's condition (e.g., healthy/sick and or flare/remission). Using these classification models, various embodiments enable diagnosis based on spectra data from a blood sample or other biomedical specimen. Exemplary embodiments may be useful for rapid diagnosis of IC and various other conditions in humans, cats, and/or other mammals. | 12-22-2011 |
| 20110311555 | Tc11 as a Transcriptional Regulator - Methods and compositions for the diagnosis, prognosis and/or treatment of B cell chronic lymphocytic leukemia associated diseases are disclosed. | 12-22-2011 |
| 20110280913 | Methods and Compositions for Delivering Therapeutic Agents in the Treatment of B-Cell Related Disorders - Methods and compositions for treating and/or diagnosing a B-cell malignancy are described. | 11-17-2011 |
| 20110280865 | Ets-2 Biomarkers for Fibrotic Diseases and Uses Thereof - Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described. | 11-17-2011 |
| 20110275534 | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Ovarian Cancer Using a Real-Time PCR Platform - Methods and compositions for the diagnosis, prognosis and/or treatment of ovarian cancer are disclosed. | 11-10-2011 |
| 20110274718 | System for Modulating Expression of Hypothalmic Brain-Derived Neurotrophic Factor (BDNF) - Methods for treating tumor associated diseases by administering a nucleic acid sequence encoding brain derived neurotrophic factor (BDNF) where the expression reduces the symptoms of the disease and compositions for mediation of enrichment-induced tumor resistance having brain derived neurotrophic factor (BDNF) are disclosed. | 11-10-2011 |
| 20110250608 | USE OF ULTRACONSERVED RNA IN DETECTION AND TREATMENT OF CANCER - A method of analyzing a biological specimen to detect cancer in a subject, involving determining an ultraconserved RNA in the specimen and comparing the expression level to a control. The ultraconseved RNA may be uc.338 and may be used to detect hepatocellular cancer. Transcript RNA encoding ultraconserved RNA may also be used to detect cancer. Anti-cancer compositions and tumor-suppressing agents for treating cancer are also provided. | 10-13-2011 |
| 20110248209 | THERMOELECTRIC FIGURE OF MERIT ENHANCEMENT BY MODIFICATION OF THE ELECTRONIC DENSITY OF STATES - A thermoelectric material and a method of using a thermoelectric material is provided. The thermoelectric material can include at least one compound. For example, the at least one compound may be a Group IV-VI compound such as lead telluride. The at least one compound may further include one or more dopants such as sodium, potassium, and thallium. The method of using a thermoelectric material can include exposing at least one portion of the at least one compound to a temperature greater than about 700 K. | 10-13-2011 |
| 20110190383 | Diagnostic, Prognostic and Therapeutic Uses of MIRs in Adaptive Pathways and/or Disease Pathways - Described herein are methods and compositions for the diagnosis, prognosis and treatment of various adaptive and/or of disease pathways by examining samples containing one or more miRs therein, and by formulating therapeutic agents therefrom. | 08-04-2011 |
| 20110190160 | MicroRNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF LUNG CANCER USING MIR-21 - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provides methods of identifying anti-lung cancer agents. | 08-04-2011 |
| 20110177968 | MicroRNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF LUNG CANCER USING MIR-17-3P - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provides methods of identifying anti-lung cancer agents. | 07-21-2011 |
| 20110168897 | RAPID DIAGNOSIS OF A DISEASE CONDITION USING INFRARED SPECTROSCOPY - Reliable and rapid diagnostic methods for many functional syndromes (FS) such as Bladder Pain Syndrome/Interstitial Cystitis (IC) are not available. Exemplary embodiments include rapid and accurate methods for diagnosing FS in humans and domestic cats using infrared microspectroscopy (IRMS). Exemplary methods utilize Soft Independent Modeling by Class Analogy (SIMCA) to create classification models. Exemplary methods utilize classification models to classify a test subject's condition (e.g., healthy/sick). Using these classification models, various embodiments enable diagnosis based on spectra data from a fluid biomedical specimen. Exemplary embodiments may be useful to rapidly diagnose IC and various other conditions in humans, cats, and/or other mammals. | 07-14-2011 |
| 20110152357 | Micro-RNA-Based Compositions and Methods for the Diagnosis, Prognosis and Treatment of Multiple Myeloma - Methods for assessing a pathological condition in a subject includes measuring an expression profile of one or more markers where a difference is indicative of multiple myeloma (MM) or a predisposition to MM. The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of MM. The invention also provides methods of identifying anti-MM cancer agents. | 06-23-2011 |
| 20110151529 | METHODS AND PROCESSES FOR PRODUCING ORGANIC ACIDS - A fermentation process for the production of organic acids is provided and includes, providing metabolically engineered mutant bacteria which have had one or both of ack and pta genes disrupted, adapting the mutant bacteria to increase their resistance to acids and to increase their growth rate by immobilizing the mutant bacteria while exposing the mutant bacteria to a fermentable substrate, and further exposing the adapted mutant bacteria to a fermentable substrate for a time sufficient to provide a final organic acid fermentation product concentration of greater than about 50 g/L. | 06-23-2011 |
| 20110151061 | FOOD DECORATION - Various embodiments relate to a method and an arrangement for printing an indicium onto an edible media. In some embodiments, the film is affixed onto a support material. In various embodiments, the film comprises a chitosan polymer. In other embodiments, the film comprises a blend of protein, polysaccharides, and lipids instead of chitosan. | 06-23-2011 |
| 20110124521 | Use of MiR-26 Family as a Predictive Marker for Hepatocellular Carcinoma and Responsiveness to Therapy - It is disclosed herein that expression of microRNA-26 is decreased in hepatocellular (HCC) tumor tissue relative to non-cancerous tissue, and that a low level of microRNA-26 is associated with a poor clinical outcome. It is also disclosed herein that a low expression level of microRNA-26 is correlated with a favorable response to interferon (IFN)-α therapy in HCC patients. Thus, provided herein is a method of predicting the clinical outcome of a patient diagnosed with HCC comprising detecting the level of microRNA-26 expression in a sample obtained from the patient. Also provided is a method of selecting a patient diagnosed with HCC as a candidate for IFN-α therapy, comprising detecting the level of microRNA-26 expression in a sample obtained from the patient. A method of identifying therapeutic agents for the treatment of HCC, comprising screening candidate agents in vitro to select an agent that increases expression of microRNA-26 in HCC cells are also provided. Further provided are methods of treating a patient diagnosed with HCC and expressing a low level of miR-26, wherein treatment comprises IFN-α therapy. | 05-26-2011 |
| 20110124077 | MOBILE MAGNETIC TRAPS AND PLATFORMS FOR MICRO/NANO PARTICLE MANIPULATION - Magnetic array platforms such as nano or micro-wire networks that produce trapping, manipulation, and transport of micro- or nano-scale particles such as non-biological entities such as magnetic particles and cells, viruses, DNA, proteins, and other biological entities having magnetic particles labeled or tethered thereto are provided. Methods of manipulating, transporting, and sorting micro- or nano-scale particles are described. | 05-26-2011 |
| 20110104069 | MULTI-FUNCTIONAL BIODEGRADABLE PARTICLES FOR SELECTABLE TARGETING, IMAGING, AND THERAPEUTIC DELIVERY AND USE THEREOF FOR TREATING OCULAR DISORDERS - In various embodiments, provided are multi-functional biodegradable particles for selectable targeting, imaging, and delivery of therapeutic agents. Also provided are methods of using the provided particles for treatment of ocular disorders, such as for the treatment of age-related macular degeneration. The provided particles and methods provide a clinician with options for control over, and monitoring of, the delivery of therapeutic agents. | 05-05-2011 |
| 20110070782 | MARINE PROPULSION SYSTEM - A marine propulsion system comprising: a fuel-filled tank; an air compressor that generates compressed air; an engine that receives fuel from the tank, wherein the air compressor is powered by the engine; and at least one hot gas generator that receives compressed air from the air compressor, the hot gas generator comprising: (a) a combustion chamber having an inlet and an outlet, the compressed gas injected into the combustion chamber at the inlet, the combustion chamber adapted to produce hot gas; (b) an injection nozzle that receives fuel from the tank, the injection nozzle positioned proximate to the inlet of the combustion chamber, the injection nozzle adapted to spray the fuel into the combustion chamber; and (c) an exhaust nozzle positioned at the outlet of the combustion chamber through which the hot gas produced in the combustion chamber is discharged from the hot gas generator. | 03-24-2011 |
| 20110064797 | CAPSULE OF THERMOGENIC CELLS FOR TREATING A METABOLIC DISEASE - Described herein are methods and devices for treating a metabolic disease that involve implanting a micro-device into a tissue of a subject having a metabolic disease. The micro-device includes a plurality of thermogenic cells encapsulated in a biocompatible capsule. The capsule includes a core to accommodate the plurality of thermogenic cells and a porous immunoprotective membrane that allows for metabolic interaction between the plurality of thermogenic cells and the tissue. | 03-17-2011 |
| 20110000953 | LOW-TEMPERATURE SPOT IMPACT WELDING DRIVEN WITHOUT CONTACT - A laser, aimed at a flyer plate tab, causes optical energy to be directed at the tab, specifically, at a top surface thereof. Energy impacting the tab accelerates the tab out of an initial bent position, straightening it into an impact with a target sheet. The impact occurs in excess of 100 m/s, resulting in a metallurgical bond between the tab and the target sheet. The laser preferably strikes the top surface in a normal direction, based upon an initial angularity of the tab relative to the target. The laser emission, preferably in the range of 1 to 100 Joules delivered in a microsecond, may be augmented by an ablative layer on the top surface or a transparent covering on the top surface that reacts against the expanding gas from ablative activity on the top surface. The weld is formed without physical contact between the welding device and the tab. | 01-06-2011 |
| 20110000022 | Portable Extremity Assessment And Management Device - A device and method for elevating and supporting a patient's extremity to facilitate convenient examination and treatment of the extremity. The device includes a base, longitudinally-spaced upstanding support members extending upwardly from the base, and extremity securing mechanisms mounted to the upstanding support members upon which a patient's extremity can be positioned. The method generally includes extending a patient's extremity longitudinally across the extremity securing mechanisms and bringing the extremity to rest thereon. Caregivers and surgical teams are thus provided with access to the full circumference of the portion of the patient's extremity that extends between the extremity securing mechanisms. Several embodiments of the device incorporate means for assisting in the lifting of a patient's extremity to a desired height, including hydraulic rams, levers, and inflatable bladders. | 01-06-2011 |
| 20100301217 | MINIATURE PHASE-CORRECTED ANTENNAS FOR HIGH RESOLUTION FOCAL PLANE THz IMAGING ARRAYS - An array of backward diodes of a cathode layer adjacent to a first side of a non-uniform doping profile and an Antimonide-based tunnel barrier layer adjacent to a second side of the spacer layer have a monolithically integrated antenna bonded to each backward diode. The Antimonide-based tunnel barrier may be doped with, for example, a non-uniform delta doping profile. An imaging/detection device includes a 2D focal plane array of an array of backward diodes, wherein each backward diode is monolithically bonded to an antenna, which array is located at the back of an extended hemispherical lens, and wherein certain of the arrays are tilted for correcting optics aberrations. The antennas may be a bow-tie antenna, a planar log-periodic antenna, a double-slot with microstrip feed antenna, a spiral antenna, a helical antenna, a ring antenna, a dielectric rod antenna, or a double slot antenna with co-planar waveguide feed antenna. | 12-02-2010 |
| 20100286232 | MICRORNA EXPRESSION PROFILE ASSOCIATED WITH PANCREATIC CANCER - Methods are provided for diagnosing whether a subject has, or is at risk of developing, pancreatic cancer. The methods include measuring the level of at least one miR gene product in a biological sample derived from the subject's pancreas. An alteration in the level of the miR gene product in the biological sample as compared to the level of a corresponding miR gene product in a control sample, is indicative of the subject either having, or being at risk for developing, pancreatic cancer. | 11-11-2010 |
| 20100273258 | Interactive Microenvironment System - A culture cell for growing animal cells in vitro has sides and a bottom forming a volume. The volume contains a layer of nanofiber upon which animal cells can be cultured. The layer of nanofiber can be oriented or non-oriented. Multiple layers can be placed in the volume, where the layers have different composition and/or different porosity. The nanofiber can be, for example, surface treated or of a core-shell construction. | 10-28-2010 |
| 20100272636 | Anti-CD74 Immunoconjugates and Methods of Use - Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions. | 10-28-2010 |
| 20100258154 | THERMOELECTRIC ALLOYS WITH IMPROVED THERMOELECTRIC POWER FACTOR - A thermoelectric material and a method of using a thermoelectric device are provided. The thermoelectric material includes at least one compound having a general composition of (Bi | 10-14-2010 |
| 20100234588 | SYNTHETIC METHOD FOR CERATAMINE A AND B AND ANALOGS THEREOF - Methods are provided for preparing compounds of the general formula (I) | 09-16-2010 |
| 20100227776 | Rapid Genotyping of SNPs - Embodiments include a universal and generic method for rapidly genotyping essentially any single nucleotide polymorphism (SNP) and or other polymorphism. Various embodiments include procedures for SNP and/or allele analysis that are easy, cheap, highly multiplexable, easily automatable, and lend themselves to high-throughput. Embodiments are broadly applicable for all applications where SNP determinations are useful. | 09-09-2010 |
| 20100190703 | PEPTIDES SPECIFIC FOR HUMAN BLOOD OUTGROWTH ENDOTHELIAL CELLS - Provided herein are compositions and methods for binding outgrowth endothelial cells (OEC). The compositions consist of peptide ligands capable of binding OEC with high affinity and specificity. The compositions of the invention include peptides set forth in SEQ ID NO: 1-38 and variants and derivatives thereof. Compositions also include the nucleotide sequences encoding the peptides of the invention. The compositions find use in methods for the isolation of OEC and for the recruitment and retention of OEC to sites of therapeutic interest. Methods for the identification and isolation of other peptides capable of binding OEC are also provided. | 07-29-2010 |
| 20100124773 | METHODS AND PROCESSES FOR PRODUCING ESTERS - Methods are provided for producing esters. The methods comprise converting a fermentable carbon source to organic acids by fermentation with organic acid producing microorganisms, followed by catalytic esterification. The methods comprise integrated fermentation, extraction, and esterification reactions wherein the organic acids produced during fermentation are extracted into an extraction solvent and then directly reacted with an alcohol in the presence of a catalyst to form organic esters. Methods of producing esters are also provided wherein the organic acids produced during fermentation and extracted into the extraction solvent are stripped from the extraction solvent prior to being reacted with an alcohol in the presence of a catalyst to form organic esters. | 05-20-2010 |
| 20100112071 | POLYPEPTIDES AND POLYNUCLEOTIDES FOR ENHANCING IMMUNE REACTIVITY TO HER-2 PROTEIN - Compositions for stimulating the immune system and for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include immunogenic epitopes of the HER-2 proteins and chimeric and multivalent peptides which comprise such epitopes. The present invention also relates to polynucleotides which encode the chimeric peptides. Also provided are pharmaceutical compositions comprising such immunogenic compositions. Methods for stimulating an immune response to HER-2 protein are provided. Methods for treating breast cancer, ovarian cancer, prostate cancer, colon cancer and lung cancer are provided. | 05-06-2010 |
| 20100097374 | 3D AND REAL TIME ELECTRICAL CAPACITANCE VOLUME-TOMOGRAPHY SENSOR DESIGN AND IMAGE RECONSTRUCTION - Dynamic three-dimensional image electrical capacitance tomography sensor system is disclosed. The technique generates, from the measured capacitance, a whole volume image of the region enclosed by the a geometrically three-dimensional capacitance sensor. A real time, three-dimensional imaging of a moving object or a real time volume imaging (i.e., four-dimensional (4D)) allows for a total interrogation scheme of the whole volume within the domain of an arbitrary shape of geometry to be implemented. The system comprises a 3D capacitance sensor, data acquisition electronics and the image reconstruction algorithm which enables the volume-image reconstruction. The electrode shape of the capacitance sensor can be rectangular, triangular, trapezium, or any shape to enclose a 3D section of the measuring domain and to distribute the electrical field intensity in three directions with equal sensitivity strength. The image reconstruction algorithm reconstructs simultaneously the image voxels in a three-dimensional array. The tomography sensor system may be multimodal. | 04-22-2010 |
| 20100093052 | MAGNETIC CELL SEPARATION - Systems and methods are provided separating a first group of cells from a mixture of at least first and second groups of cells in a suspending fluid. The system includes an annular flow channel and at least one magnetic element positioned around the exterior of the annular flow channel as to provide a radially symmetric magnetic field around at least a portion of the annular flow channel. The at least one magnetic element is configured to provide a gradually increasing magnetic field along the axis of flow as to limit the maximum magnetic gradient within the annular flow channel. A pump is operatively connected to a terminal end of the annular flow channel to force the suspending fluid through the annular channel. | 04-15-2010 |
| 20100071556 | STABLE SUPPORTED Pd-ALLOY MEMBRANES - A Pd alloy membrane and method of making are described. | 03-25-2010 |
| 20100056800 | METHOD OF SYNTHESIZING 1H-INDAZOLE COMPOUNDS - A method is provided for synthesizing 1H-indazole compounds in which aromatic carbonyl compounds are reacted with a nitrogen source to form oximes which are then converted to 1H-indazoles. | 03-04-2010 |
| 20100028604 | HIERARCHICAL STRUCTURES FOR SUPERHYDROPHOBIC SURFACES AND METHODS OF MAKING - Embodiments of a superhydrophobic structure comprise a substrate and a hierarchical surface structure disposed on at least one surface of the substrate, wherein the hierarchical surface structure comprises a microstructure comprising a plurality of microasperities disposed in a spaced geometric pattern on at least one surface of the substrate. The fraction of the surface area of the substrate covered by the microasperities is from between about 0.1 to about 1. The hierarchical structure comprises a nanostructure comprising a plurality of nanoasperities disposed on at least one surface of the microstructure. | 02-04-2010 |
| 20090263316 | HIGH PURITY, HIGH PRESSURE HYDROGEN PRODUCTION WITH IN-SITU CO2 AND SULFUR CAPTURE IN A SINGLE STAGE REACTOR - A process for producing hydrogen, comprising the steps of: (a) gasifying a fuel into a raw synthesis gas comprising CO, hydrogen, steam and sulfur and halide contaminants in the form of H | 10-22-2009 |
| 20090261026 | BI-PHASIC BIORETENTION SYSTEM - An anaerobic to aerobic sequence enhances biological degradation of many organic pollutants. Exemplary embodiments provide systems and methods for effective treatment of storm-water runoff pollutants such as hydrocarbons, nitrates, phosphorus, and heavy metals using sediment filtration and adsorption, and biochemical processes under bi-phasic bioretention conditions. By integrating these pollution cleanup pro-usages into a single unit, this apparatus optimizes retention time of the runoff through the system and maximizes removal rates of runoff pollutants, resulting in more reliable and efficient treatment mechanism than previous systems. | 10-22-2009 |
| 20090259121 | SYSTEM AND METHOD FOR CARDIOVASCULAR EXERCISE STRESS MRI - A system and method for cardiovascular exercise stress magnetic resonance using a MRI-compatible treadmill and real-time imaging. The treadmill comprises non-ferromagnetic components so that it may be used in proximity to a MRI scanner. The treadmill is positioned adjacent to the MRI scan table. A treadmill control system is used to control the speed and grade of the treadmill to allow it to perform a wide range of exercise protocols. Patients complete an exercise protocol on the treadmill and are then moved to the MRI scan table. Images are acquired as quickly as possible post-exercise to more accurately diagnose cardiovascular disease in patients. | 10-15-2009 |
| 20090222934 | Pre-B Cell Proliferation and Lymphoblastic Leukemia/High-Grade Lymphoma in MIR155 Transgenic Mice - A transgenic non-human animal, such as a mouse, has a genome that include a nucleic acid construct having at least one transcriptional regulatory sequence capable of directing expression in B cells of the animal, wherein the transcriptional regulatory sequence is operably linked to a nucleic acid encoding a miR155 gene product. A method of testing the therapeutic efficacy of an agent in treating or preventing a lymphoproliferative condition includes assessing the effect(s) of the agent on a transgenic non-human animal. | 09-03-2009 |
| 20090209450 | MicroRNA Fingerprints During Human Megakaryocytopoiesis - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer and myeloproliferative disorders. The invention also provides methods of identifying anti-cancer agents. | 08-20-2009 |
| 20090208417 | Detection and Localized Imaging of Cancer Using X-Ray Fluorescent Nanoparticle/Preferential Locator Conjugates - A method for detecting gold or other nanoparticles conjugated to preferential locators commences by contacting tissue suspected of being neoplastic with gold nanoparticle/preferential locator conjugates for a time adequate for the conjugates to bind with the tissue. A beam of gamma photons (such as from, | 08-20-2009 |
| 20090130166 | SYSTEM FOR PROVIDING IMPLANT COMPATIBILITY WITH RECIPIENT - A system for providing or enhancing compatibility between an implant and a recipient. The system includes a recipient, typically a living biological organism, that further includes a target region; an implant having a first attraction means; and a plurality of cells. The cells are compatible with the target region and further include a second attraction means responsive to the first attraction means. The interaction between the first and second attraction means attaches the cells to the implant. | 05-21-2009 |
| 20080312162 | Methods and Compositions for Enzyme-Specific Activation of Carbohydrate-Conjugated Prodrugs - Methods for the targeted activation of prodrugs by enzymes, which cleave a linkage between a carbohydrate conjugate and a drug. Means to target the activation of prodrugs to specific cells by linking the enzyme to an antibody molecule. Carbohydrate conjugates of geldanamycin. | 12-18-2008 |
| 20080306018 | Micro-Rna Expression Abnormalities of Pancreatic, Endocrine and Acinar Tumors - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic cancer agent. | 12-11-2008 |
| 20080306017 | Microrna-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Lung Cancer - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provide methods of identifying anti-lung cancer agents. | 12-11-2008 |
| 20080306006 | MicroRna-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Solid Cancers - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provide methods of identifying inhibitors of tumorigenesis. | 12-11-2008 |
| 20080300485 | ULTRASONIC SYSTEM AND METHOD FOR MEASUREMENT OF OCULAR BIOMECHANICS - A system and a method for non-invasively ultrasonically measuring biomechanical properties of ocular tissue in vivo is presented. The method comprises positioning an ultrasonic transducer proximally to the ocular tissue. Reflections of the ocular tissue can be ultrasonically obtained using the ultrasonic transducer. The ultrasonic reflections can be converted into reflection spectra. Biomechanical properties of the ocular tissue, such as, for example, thickness, corneal stiffness, density, and longitudinal modulus, can be determined based on the reflection spectra. A wave propagation model can be developed to simulate ultrasound propagation of ocular tissue in vivo. The ultrasonic non-destructive evaluation method and system for the non-invasive measuring of reflection spectra and determining biomechanical properties of ocular tissue in vivo can provide information for ocular disease management and therapeutic and refractive procedures. | 12-04-2008 |
| 20080261908 | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of breast cancer. The invention also provides methods of identifying anti-breast cancer agents. | 10-23-2008 |
| 20080260230 | Method and Apparatus for Detecting Intraventricular Dyssynchrony - A method and apparatus for detecting intraventricular dyssynchrony is provided. In one embodiment, the method includes: a) receiving information from an observer viewing a source image to define a plurality of points associated with muscle boundaries of a ventricle, b) extracting muscle boundaries for a series of source images to define a corresponding series of contour shape images using a Fourier descriptor model, and c) deforming each contour shape based at least in part on image forces, external forces, and internal forces to track movement of the muscle boundaries over time. In another embodiment, the method includes: a) characterizing the series of source images as a corresponding series of contour shape images representative of movement of muscle boundaries of the ventricle over time, b) classifying the series of contour shape images in a dyssynchronous class or a non-dyssynchronous class, and c) pre-diagnosing the ventricle as dyssynchronous or non-dyssynchronous. | 10-23-2008 |
| 20080253638 | Method and Apparatus for Detecting Interventricular Dyssynchrony - Several embodiments of a method and apparatus for detecting interventricular dyssynchrony are provided. In one embodiment, the apparatus includes an image segment processor and an image classifier. The image segment processor may segment left and right ventricles in source images of a subject's heart to form left and right ventricle segments in segmented images. Each source image may include cross sections of the right and left ventricles in common spatial relation along the short axis plane and in common temporal relation in reference to a cardiac cycle. The source images and corresponding segmented images may be temporally-spaced in relation to the cardiac cycle. The image classifier may determine first and second cross-sectional areas associated with the left and right ventricle segments for each segmented image, compare the first and second cross-sectional areas, and classify the subject's heart in an interventricular dyssynchronous class or a non-dyssynchronous class. | 10-16-2008 |
| 20080248540 | METHODS OF PRODUCING BUTANOL - A method of producing butanol from carbohydrates is provided. A feedstock comprising a carbohydrate source is fermented in the presence of bacteria to produce butyric acid and hydrogen. The butyric acid is then hydrogenated in the presence of a catalyst to produce butanol. | 10-09-2008 |
| 20080233564 | Methods of Using Databases to Greate Gene-Expression Microarrays, Microarrays Greated Thereby, and Uses of the Microarrays - Methods of preparing biological databases, and databases prepared according to those methods. In some embodiments, the methods can be performed entirely using computer resources, relying solely on publicly available biological sequence information. The methods of the invention can be used to generate species-specific nucleic acid microarrays | 09-25-2008 |
| 20080233045 | Catalyst for Hydrogen Production From Water Gas Shift Reaction - Fe—Al—Cu catalysts have numerous industrial applications, for example, as catalysts in a water gas shift reactor. A method of producing a Fe—Al—Cu catalyst comprises the steps of providing an organic iron precursor, dissolving the organic iron precursor in a solvent solution, adding an aqueous solution comprising aluminum nitrate and copper nitrate to the organic iron pre-cursor-solvent solution, precipitating a gel comprising Fe—Al—Cu by adding a base, and drying the gel to form the Fe—Al—Cu catalyst. | 09-25-2008 |
| 20080233029 | Separation of Carbon Dioxide (Co2) From Gas Mixtures By Calcium Based Reaction Separation (Cars-Co2) Process - A reaction-based process has been developed for the selective removal of carbon dioxide (CO | 09-25-2008 |
| 20080206736 | FLAVIN N-OXIDES: NEW ANTI-CANCER AGENTS AND PATHOGEN ERADICATION AGENTS - Compounds comprising flavin N-oxides for treatments of solid tumors, non-solid tumor masses, leukemias, and non-small cell lung cancers and for eradicating contaminants in blood products. Methods of treating patients having solid type cancers comprising administering a therapeutically effective amount of a flavin N-oxide to a subject in need of treatment and exposing the flavin N-oxide to an activator such that activation of the flavin N-oxide results in damage to the DNA in the cancer cells without substantial damage to the DNA of normal cells are also provided. Methods of using a flavin N-oxide as part of a combination therapy with chemotherapy, radiation therapy, or both are also provided. Methods of reducing pathogenic bacterial or viral contamination in a composition comprising a) mixing the composition with an efficacious amount of a flavin N-oxide and b) exposing the mixture of the composition and the flavin N-oxide to an activator for a period of time sufficient to activate the flavin N-oxide such that the flavin N-oxide reduces the contamination in the composition are also provided. Preferably, the composition is a blood product selected from plasma, platelets, and red blood cells and the activator is an enzyme. | 08-28-2008 |
| 20080198074 | RECONFIGURABLE ANTENNA USING ADDRESSABLE PIXEL PISTONS - An antenna made up of addressable conductive segments, or pixel elements, affixed to the top of each piston in a piston array is presented. The pixel elements can be activated in less than a millisecond to form an antenna array and transmission line pattern using movable pistons and a two-dimensional actuator. Each piston comprises a handle, a bottom conductive segment affixed to the top of the handle, a dielectric segment affixed to the uppermost surface of the bottom conductive segment, and a top conductive segment affixed to the uppermost surface of the dielectric segment. When the piston is not actuated, the top conductive segment forms part of a ground plane. The top conductive segment form part of the transmission line and antenna array patterns, the dielectric segment becomes a dielectric space and the bottom conductive segment forms part of the ground plane when the piston is actuated. | 08-21-2008 |
