| THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION Patent applications |
| Patent application number | Title | Published |
|---|
| 20120136063 | FTY720-DERIVED ANTICANCER AGENTS - A number of FTY720-derived compounds with antitumor activity are described. These compounds include the compounds of formula I: | 05-31-2012 |
| 20120135425 | ELISA for Haptoglobin-Matrix Metalloproteinase 9 Complex as a Diagnostic Test for Conditions Including Acute Inflammation - A method for detecting a haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) complex in a biological sample. The sample includes incubating the biological sample with a capture reagent immobilized on a solid support to bind Hp-MMP 9 to the capture reagent. The capture reagent includes a monoclonal antibody that binds MMP9. The method detects Hp-MMP 9 bound to the immobilized capture reagent by contacting the bound Hp-MMP 9 with a detectable antibody that binds to Hp. | 05-31-2012 |
| 20120121626 | Chimeric VEGF Peptides - Compositions for and methods of treating patients with malignancies associated with overexpression of VEGF, particularly ovarian cancer are provided herein. The compositions include but are not limited to certain VEGF epitopes, multivalent peptides comprising the epitopes, and chimeric peptides comprising one or more of the epitopes and a T cell epitope. | 05-17-2012 |
| 20120108823 | ANTI-FRANCISELLA AGENTS - A series of celecoxib derivatives defined by Formula I: | 05-03-2012 |
| 20120095443 | NANOCHANNELED DEVICE AND RELATED METHODS - A capsule configured for in vivo refilling of a thereapeutic agent. In certain embodiments, the capsule may contain methotrexate. | 04-19-2012 |
| 20120077700 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-29a - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 03-29-2012 |
| 20120077699 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-103-2 - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 03-29-2012 |
| 20120065098 | METHOD OF PREDICTING CHEMOTHERAPY EFFECTIVENESS IN COLON ADENOCARCINOMA PATIENTS, USING MIR-21 - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 03-15-2012 |
| 20120065097 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-106a - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 03-15-2012 |
| 20120058915 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-10a - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 03-08-2012 |
| 20120058914 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-203 - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 03-08-2012 |
| 20120058913 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-16b - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 03-08-2012 |
| 20120058912 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING let-7g - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 03-08-2012 |
| 20120058911 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-181b - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 03-08-2012 |
| 20120058910 | METHOD FOR DIAGNOSING ACUTE LYMPHOMIC LEUKEMIA (ALL) USING MIR-125b - Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins. | 03-08-2012 |
| 20120046194 | METHOD FOR DIAGNOSING ACUTE LYMPHOMIC LEUKEMIA (ALL) USING MIR-146a - Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins. | 02-23-2012 |
| 20120046193 | METHOD FOR DIAGNOSING ACUTE LYMPHOMIC LEUKEMIA (ALL) USING MIR-222 - Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins. | 02-23-2012 |
| 20120046192 | METHOD FOR DIAGNOSING ACUTE LYMPHOMIC LEUKEMIA (ALL) USING MIR-221 - Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins. | 02-23-2012 |
| 20120045778 | ELISA FOR HAPTOGLOBIN-MATRIX METALLOPROTEINASE 9 COMPLEX AS A DIAGNOSTIC TEST FOR CONDITIONS INCLUDING ACUTE INFLAMMATION - A method for detecting a haptoglobin-matrix metalloproteinase 9 (Hp-MMP9) complex in a biological sample. The sample includes incubating the biological sample with a capture reagent immobilized on a solid support to bind Hp-MMP9 to the capture reagent. The capture reagent includes a monoclonal antibody that binds MMP9. The method detects Hp-MMP9 bound to the immobilized capture reagent by contacting the bound Hp-MMP9 with a detectable antibody that binds to Hp. | 02-23-2012 |
| 20120040347 | Polymorphism in CYP3A4 Gene Affecting Drug Metabolizing and Uses Thereof - A method for predicting a subject's risk factors for CYP3A4-related disorders includes detecting the allelic status of a SNP in a nucleic acid sample of the subject. | 02-16-2012 |
| 20120031833 | SYSTEMS, COMPOSITIONS, AND METHODS FOR FLUID PURIFICATION - Disclosed herein are membranes comprising a substrate, a support layer, and a selective layer. In some embodiments the membrane may further comprise a permeable layer. Methods of forming membranes are also disclosed comprising forming a support layer on a substrate, removing adsorbed species from the support layer, preparing a solution containing inorganic materials of a selective layer, contacting the support layer with the solution, drying the membrane, and exposing the membrane to rapid thermal processing. Also disclosed are methods of fluid purification comprising providing a membrane having a feed side and a permeable side, passing a fluid mixture across the feed side of the membrane, providing a driving force for transmembrane permeation, removing from the permeate side a permeate stream enriched in a purified fluid, and withdrawing from the feed side a fluid that is depleted in a purified fluid. | 02-09-2012 |
| 20120028833 | MiR-25-BASED METHODS FOR THE DIAGNOSIS AND PROGNOSIS OF ACUTE MYELOID LEUKEMIA (AML) - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). The invention also provides methods of identifying anti-AML agents. | 02-02-2012 |
| 20120028832 | MiR-182-, miR-191, miR-199a-BASED METHODS FOR THE DIAGNOSIS AND PROGNOSIS OF ACUTE MYELOID LEUKEMIA (AML) - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). | 02-02-2012 |
| 20120028831 | MiR-29-BASED METHODS FOR THE DIAGNOSIS AND PROGNOSIS OF ACUTE MYELOID LEUKEMIA (AML) - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). The invention also provides methods of identifying anti-AML agents. | 02-02-2012 |
| 20120010092 | Methods for Identifying Fragile Histidine Triad (FHIT) Interaction and Uses Thereof - Provided herein are methods and compositions for the diagnosis, prognosis and treatment of a cancer associated disorder using the Fhit gene. | 01-12-2012 |
| 20110293570 | ISOLATION OF NOVEL BACTERIA CONTRIBUTING TO SOILBORNE DISEASE SUPPRESSION - Embodiments relate to plant disease suppressive microorganisms and compositions including the same, methods for isolating disease suppressive microorganisms, and methods for controlling plant diseases using disclosed compositions and microorganisms. | 12-01-2011 |
| 20110288160 | Treatment of Metabolic-Related Disorders Using Hypothalamic Gene Transfer of BDNF and Compositions Therefor - Described herein is a system which uses a gene therapy particle that includes at least one gene, cDNA, fragment or analogue of at least one neurotropin that binds to the trkB receptor or the trkB receptor itself. The gene therapy particle is capable of being delivered to a subject in need thereof for therapy of a metabolic disorder. In a particular aspect, this invention is directed to an inventive method that demonstrates a remarkable efficacy on lowering body weight. | 11-24-2011 |
| 20110286902 | CARBONATION CALCINATION REACTION PROCESS FOR CO2 CAPTURE USING A HIGHLY REGENERABLE SORBENT - A process for the efficient capture of CO | 11-24-2011 |
| 20110269906 | MEMBRANES, METHODS OF MAKING MEMBRANES, AND METHODS OF SEPARATING GASES USING MEMBRANES - Membranes, methods of making membranes, and methods of separating gases using membranes are provided. The membranes can include at least one hydrophilic polymer, at least one cross-linking agent, at least one base, and at least one amino compound. The methods of separating gases using membranes can include contacting a gas stream containing at least one of CO | 11-03-2011 |
| 20110250568 | DENTIN ANCHOR - A fiber-reinforced composite (FRC) dentin anchor is disclosed comprising a frusto-conical shaped coronal portion, to which a tooth restorative material may be secured, and a frusto-conical shaped dentinal portion, adapted to be received in a pre-drilled hole in tooth dentin. The dentinal portion may be adapted to chemically bond to the tooth without the use of threads and the coronal portion may be adapted to chemically bond to a tooth restoration without the use of additional adhesives. The modulus of elasticity of the dentin anchor may approximate the modulus of elasticity of tooth dentin. | 10-13-2011 |
| 20110247492 | MODIFIED ZEOLITE Y MEMBRANES FOR HIGH-PERFORMANCE CO2 SEPARATION - Supported zeolite Y membranes exhibiting exceptionally high CO2 selectivities when used in CO | 10-13-2011 |
| 20110240904 | SURFACTANT-FREE SYNTHESIS AND FOAMING OF LIQUID BLOWING AGENT-CONTAINING ACTIVATED CARBON-NANO/MICROPARTICULATE POLYMER COMPOSITES - Exemplary embodiments of the present invention relate to polystyrene and/or thermoplastic polymer or polymer blend composite foam or a foamable polymeric material precursor, which contains activated carbon and/or at least one of 1-dimensional, 2-dimensional, and 3-dimensional nano/micro-materials in polystyrene and/or thermoplastic polymer and/or polymer blend matrix to carry a co-blowing agent such as water without using any surfactant-like molecules and/or polymers, having or adapted to have the properties of low density, high-R value, good mechanical properties, and fire retardance thereof. Exemplary embodiments of the present invention include various manufacturing methods that may be employed including, but not limited to, extrusion, batch molding, and injection molding. One example includes synthesis and CO | 10-06-2011 |
| 20110214487 | ELECTRO-SPUN FIBERS AND APPLICATIONS THEREFORE - A supported nanofiber medium useful for segregating chemical species is provided by selecting a polymer, selecting a substrate; and electrospinning the polymer to form a nanofiber medium on the supporting substrate. When the substrate is a planar surface, the nanofiber medium will be a mat suitable for conducting chromatographic separation. When the substrate is a filament, the nanofiber medium is an annular mat suitable for solid phase microextraction. The nanofiber media formed may be selectively cross-linked and at least partially carbonized to carbon nanofibers. The nanofiber medium is supported on the substrate without the use of binder material. | 09-08-2011 |
| 20110200520 | CALCIUM LOOPING PROCESS FOR HIGH PURITY HYDROGEN PRODUCTION INTEGRATED WITH CAPTURE OF CARBON DIOXIDE, SULFUR AND HALIDES - A process for producing hydrogen comprising the steps of: (i) gasifying a fuel into a raw synthesis gas comprising CO, hydrogen, steam, sulfur and halide contaminants in the form of H | 08-18-2011 |
| 20110195433 | Methods for Screening of Opioid Receptor Neutral Antagonists and Inverse Agonists and Uses Thereof - Methods for screening of opioid receptor neutral antagonists and inverse agonists and uses thereof are disclosed. | 08-11-2011 |
| 20110179501 | Methods for Reverting Methylation by Targeting DNMT3A and DNMT3B - Methods for restoring a desired pattern of DNA methylation, inducing re-expression of methylation-silenced tumor suppressor genes (TSGs), and/or inhibiting tumorigenicity both in vitro and in vivo in a subject in need thereof by administering an effective amount of one or more miR-29s sufficient to target one or more of DNMT3A and DNMT3B are disclosed. | 07-21-2011 |
| 20110171646 | MICRORNA EXPRESSION PROFILE ASSOCIATED WITH PANCREATIC CANCER - Methods are provided for diagnosing whether a subject has, or is at risk of developing, pancreatic cancer. The methods include measuring the level of at least one miR gene product in a biological sample derived from the subject's pancreas. An alteration in the level of the miR gene product in the biological sample as compared to the level of a corresponding miR gene product in a control sample, is indicative of the subject either having, or being at risk for developing, pancreatic cancer | 07-14-2011 |
| 20110169682 | LATERAL WAVE RADAR SYSTEM FOR FORWARD DETECTION - A forward-looking radar system adapted to detect and identify buried or near surface objects from a moving ground vehicle has been developed. The system incorporates a radar detection system and in one embodiment is mounted on a ground vehicle. The system is adapted to differentiate common roadway clutter from objects of interest. | 07-14-2011 |
| 20110144747 | ADJUSTABLE INTRAOCULAR LENS - Methods and devices for altering the power of a lens, such as an intraocular lens, are disclosed. In one method, the lens comprises a single polymer matrix containing crosslinkable pendant groups, wherein the polymer matrix increases in volume when crosslinked. The lens does not contain free monomer. Upon exposure to ultraviolet radiation, crosslinking causes the exposed portion of the lens to increase in volume, causing an increase in the refractive index. In another method, the lens comprises a polymer matrix containing photobleachable chromophores. Upon exposure to ultraviolet radiation, photobleaching causes a decrease in refractive index in the exposed portion without any change in lens thickness. These methods avoid the need to wait for diffusion to occur to change the lens shape and avoid the need for a second exposure to radiation to lock in the changes to the lens. | 06-16-2011 |
| 20110086895 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS - A method of inhibiting glycolysis in a subject by administering a pharmaceutical composition including a thiazolidinedione derivative to the subject is described. The thiazolidinedione derivatives are effective energy restriction mimetic agents, and can therefore be used to treat or prevent cancer in a subject, treat metabolic disorder, or increase the longevity of a subject. Various thiazolidinedione derivatives are also suitable for activating adenosine phosphate-activated protein kinase or inhibiting IL-6 expression. | 04-14-2011 |
| 20110086055 | HER2 PEPTIDES - Compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include epitopes of the HER-2 proteins. | 04-14-2011 |
| 20110085140 | APPARATUS AND METHODS FOR TESTING CONTRAST SENSITIVITY - A test for measuring the contrast sensitivity of a patient uses a set of card that each include a stimulus, such as a square wave grating, presented at a single low-spatial frequency. The gratings vary in contrast from card to card. The test allows for the determination of the maximum contrast sensitivity of the patient in a single measurement, without knowing the spatial frequency at which that maximum occurs, which is possible because the spatial frequency is low enough that it is most likely below the maximum of the contrast sensitivity function in patients of any age. | 04-14-2011 |
| 20110081396 | GLASS CERAMIC SCAFFOLDS WITH COMPLEX TOPOGRAPHY - A bioactive and bioresorbable scaffold including a glass-ceramic material including fluoroapatite and hydroxyapatite doped with about 1-5 wt.% niobium oxide that is shaped into a scaffold is described. The glass-ceramic material has high crystallinity and a complex topography which provide it with greater structural strength and bioresorbability. Methods of preparing the bioactive and bioresorbable scaffold and methods of using the scaffold for musculoskeletal engineering are also provided. | 04-07-2011 |
| 20110054059 | METHODS FOR PRODUCING POLYOLS AND POLYURETHANES - Methods for producing a polyols and polyurethanes are described. The polyols described herein can be produced directly from crude glycerin or through liquefaction of lignocellulosic biomass using a solvent comprising crude glycerin. The polyols produced in accordance with certain aspects may be derived from a significant proportion of renewable resources. | 03-03-2011 |
| 20110054009 | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Prostate Related Disorders - Methods and compositions for the diagnosis, prognosis and/or treatment of prostate associated disorders are disclosed. | 03-03-2011 |
| 20110054002 | ALKYL INDOLE-3-CARBINOL-DERIVED ANTITUMOR AGENTS - Compounds and methods for treating cancer or inducing apoptosis in proliferating cells. The compounds are shown in formula I: | 03-03-2011 |
| 20110052502 | MicroRNA Signatures Associated with Human Chronic Lymphocytic Leukemia (CCL) and Uses Thereof - Methods and compositions for the diagnosis, prognosis and/or treatment of leukemia associated diseases are disclosed. | 03-03-2011 |
| 20110050524 | RECONFIGURABLE ANTENNA USING ADDRESSABLE CONDUCTIVE PARTICLES - An antenna made up of small addressable conductive segments, or pixel elements, located in a dielectric space positioned over a two-dimensional pixel element actuator is presented. The small pixel elements can be actuated in less than a millisecond by the actuator to form patterns that create an array of patch antennas and associated transmission lines on the upper surface of the dielectric space. The pixel elements can be formed using small movable conductive particles such as metal flakes or metal chips | 03-03-2011 |
| 20110038941 | Lipid Nanoparticle Compositions and Methods of Making and Using the Same - Oligonucleotide-lipid nanoparticles made of at least one oligonucleotide, at least one lipid and at least one complexation agent for the oligonucleotide, methods of making and using, and devices for making the same are disclosed. | 02-17-2011 |
| 20110034538 | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Gastric Cancer - Methods and compositions for the diagnosis, prognosis and/or treatment of gastric cancer associated diseases are disclosed. | 02-10-2011 |
| 20110027798 | Hybridization Quantitation Method for Modified Micro-RNA and -DNA Based Oligonucleotides - Described herein is a method for the qualitative and/or quantitative determination of an analyte in a test sample which includes base pairing at least one oligonucleotide to a capture template having an overhang; and, hybridizing with a detection probe. | 02-03-2011 |
| 20110021609 | MicroRNA Signatures Associated with Cytogenetics and Prognosis in Acute Myeloid Leukemia (AML) and Uses Thereof - Methods and compositions utilizing an miRNA signature for the diagnosis, prognosis and/or treatment of leukemia associated diseases, particularly acute myeloid leukemia, are disclosed. | 01-27-2011 |
| 20110015242 | PDK-1/AKT SIGNALING INHIBITORS - Use of a new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I for inducing apoptosis in unwanted rapidly proliferating cells, for treating, inhibiting, or delaying the onset of cancer, and for preventing restenosis in a subject that has undergone an angioplasty or stent: | 01-20-2011 |
| 20110001655 | DETERMINING PHYSICAL PROPERTIES OF STRUCTURAL MEMBERS IN DYNAMIC MULTI-PATH CLUTTER ENVIRONMENTS - A method for determining a physical property of a structural member in a dynamic multi-path clutter environment is given. The method comprises transmitting an RF interrogation signal to a wireless sensor operable to receive the RF interrogation signal, produce a reference signal and a measurement signal, and transmit the reference signal and the measurement signal in the dynamic multi-path clutter environment. The reference signal is delayed by a first time delay and the measurement signal is delayed by a second time delay that is a function of the physical property to be determined. The first and second time delays are associated by a known relationship defined by the wireless sensor. The method further comprises receiving the transmitted reference signal and the transmitted measurement signal and comparing the transmitted reference signal and the transmitted measurement signal in the time domain. Finally, the method comprises using this comparison to determine the physical property of the structural member. | 01-06-2011 |
| 20100324572 | Endolumenal Restriction Method and Apparatus - An apparatus and method for non-surgically creating a restriction in a tissue is provided where a binding mechanism ( | 12-23-2010 |
| 20100323357 | MicroRNA Expression Profiling and Targeting in Peripheral Blood in Lung Cancer - A method for the diagnosis, prognosis and treatment of lung cancer by detecting at least one microRNA in peripheral blood is disclosed. | 12-23-2010 |
| 20100322977 | BIOMATERIALS, COMPOSITIONS, AND METHODS - Embodiments exploit the ability of the organism | 12-23-2010 |
| 20100317610 | Methods and Compositions for Inducing Deregulation of EPHA7 and ERK Phosphorylation in Human Acute Leukemias - Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed. | 12-16-2010 |
| 20100317073 | MOLECULAR APPROACHES FOR THE OPTIMIZATION OF BIOFUEL PRODUCTION - Embodiments of the present invention utilize rationale genetic and chemical engineering strategies to achieve even greater efficiencies in biofuel production from microalgae. These increased efficiencies may be achieved through the application of targeted and well-designed chemical and genetic engineering methods disclosed herein. The exemplary embodiments focus on increasing single cell oil yields, increased algal culture densities, and increased efficiencies in oil production. Individually or in combination, exemplary embodiments may reduce the cost to produce a barrel of biofuel to enable commercial viability. | 12-16-2010 |
| 20100285471 | Methods and Compositions for the Diagnosis and Treatment of Esphageal Adenocarcinomas - Methods and compositions for the diagnosis, prognosis and/or treatment of esophageal adenocarcinoma and Barrett's esophagus associated adenocarcinoma are disclosed, along with more markers where a difference is indicative of esophageal adenocarcinoma and squamous cell carcinoma, and/or Barrett's esophagus associated adenocarcinomas or a predisposition thereto. The invention also provides methods and compositions of identifying anti-cancer agents therefor. | 11-11-2010 |
| 20100284928 | METHODS FOR IN VIVO ATHEROSCLEROTIC PLAQUE CHARACTERIZATION USING MAGNETIC SUSCEPTIBILITY TO IDENTIFY SYMPTOM-PRODUCING PLAQUES - Methods and uses of in vivo atherosclerotic plaque characterization in a subject in need thereof, that include detecting a level of one or more iron complexes in plaque in the subject, and comparing detected level to a known value determined from subjects without an atherosclerotic condition are disclosed. | 11-11-2010 |
| 20100279292 | MicroRNA Expression in Human Peripheral Blood Microvesicles and Uses Thereof - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of disorders by examining samples containing microvesicles and miRs therein. | 11-04-2010 |
| 20100273871 | ANTICANCER TOCOPHERYL SUCCINATE DERIVATIVES - Compounds of formula I: | 10-28-2010 |
| 20100269217 | Compositions and Methods for Altering the Morphology of Plants - Compounds, methods for producing them and methods for varying the morphology of plants are disclosed. More particularly, a SUN gene can be used to alter the shape of fruit in a plant such as a tomato plant. | 10-21-2010 |
| 20100267820 | ANTIADHESION AGENTS - Vitamin E succinate derivatives according to formula I: | 10-21-2010 |
| 20100261272 | Compositions for Reducing Cell Adhesion to Bubbles - Compositions and methods for reducing gas-cell surface interface damage include a protective composition having at least sugar moiety where the sugar moiety provides a hydrophilic component to the protective composition. | 10-14-2010 |
| 20100249231 | HSP90 Inhibitors of Protein-Protein Interaction HSP90 Chaperone Complexes and Therapeutic Uses Thereof - A novel Hsp90 inhibitor that disrupts protein-protein interaction in a Hsp90 superchaperone complex without blocking ATP binding and methods for treating diseases such as pancreatic cancer are disclosed. | 09-30-2010 |
| 20100249213 | MicroRNA Signatures in Human Ovarian Cancer - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of ovarian cancer. The invention also provides methods of identifying anti-cancer agents. | 09-30-2010 |
| 20100248361 | PLATELET PRODUCTION METHODS - The present invention provides platelet production methods. The method comprises the steps of providing a cellular material and culturing the cellular material, wherein platelets are produced. The culturing may be performed on 2D or 3D cell support structure or in suspension culture. In some embodiments, all or a part of the 2D or 3D culturing may be performed in a bioreactor. In some embodiments, the method may further comprise a step of isolating a subset of cells from the starting cellular material, wherein the isolated subset of cells is then cultured, wherein platelets are produced. In yet other embodiments, the method comprises the steps of providing a cellular material, isolating a subset of cells, seeding the subset of cells into a 3D scaffold, culturing the subset of cells in a 3D scaffold, seeding the cultured subset of cells into a bioreactor, culturing the subset of cells in a bioreactor, and harvesting the cells from the bioreactor, wherein platelets are produced. | 09-30-2010 |
| 20100239489 | Methods for Controlling the Quality of Metal Nanocatalyst for Growing High Yield Carbon Nanotubes - Methods are provided for the preparation of single-walled carbon nanotubes using chemical vapor deposition processes. In some aspects, single-walled carbon nanotubes having narrow distribution of diameters are formed by contacting a carbon precursor gas with a catalyst on a support, wherein the catalyst has an average diameter of less than about 2 nm. | 09-23-2010 |
| 20100234283 | IMMUNOGENIC EPITOPES, PEPTIDOMIMETICS, AND ANTI-PEPTIDE ANTIBODIES, AND METHODS OF THEIR USE - Provided herein are compositions and methods for the treatment of cancers. The compositions comprise at least one VEGF peptide mimic, HER-2 epitope, immunogenic VEGF peptides, and HER-2 immunogenic epitopes. The peptides and epitopes may be linear, cyclized, retro-inverso, or a combination of such forms. Also provided herein are antibodies raised to VEGF peptide mimics, HER-2 epitopes, immunogenic VEGF peptides, and HER-2 immunogenic epitopes. | 09-16-2010 |
| 20100229251 | Methods and Compositions for Detecting and Treating End-Stage Cardiomyopathy Using Claudin-5 - The present invention provides a method for diagnosis end-stage cardiomyopathy includes measuring expression of claudin-5 levels in a patient suspected of suffering from end-stage cardiomyopathy as well as a method for treating end-stage cardiomyopathy includes administering an effective amount of a composition effectively upregulates the claudin-5 or inhibits degradation of claudin-5 | 09-09-2010 |
| 20100221200 | COMPOSITIONS AND METHODS FOR SKIN CARE - The present disclosure contemplates compositions and methods for skin care. In some embodiments, the compositions may comprise delta opioid receptor agonists. The skin care composition may comprise peptide delta opioid receptor agonists, non-peptide delta opioid receptor agonists, or combinations thereof. In further embodiments, the peptide delta opioid receptor agonists may be chosen from enkephalins and/or deltorphins. In yet other embodiments, the delta opioid receptor agonists may be conjugated to another molecule. For example, the delta opioid receptor agonist may be conjugated to a lipid in order to facilitate entry across the stratum corneum. Further disclosed herein is the cosmetic use of at least one combination as described above, in a composition suitable for topical application to the skin, as an agent for smoothing out wrinkles and fine lines, such as expression wrinkles. | 09-02-2010 |
| 20100216139 | METHODS, COMPOSITIONS, AND DEVICES UTILIZING MicroRNA TO DETERMINE PHYSIOLOGICAL CONDITIONS - Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes. | 08-26-2010 |
| 20100197774 | MicroRNA EXPRESSION ABNORMALITIES IN PANCREATIC ENDOCRINE AND ACINAR TUMORS - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic cancer agent. | 08-05-2010 |
| 20100197770 | Methods for Determining Heptocellular Carcinoma Subtype and Detecting Hepatic Cancer Stem Cells - The invention provides a method of determining an HCC subtype in a subject comprising a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. The invention further provides methods of detecting HCC stem cells in a sample. Additionally, the invention provides methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells. | 08-05-2010 |
| 20100186119 | Highly Active Soybean Promoters and Uses Thereof - Soybean ubiquitin promoters and processes for expressing nucleic acids in transgenic plants under the control of a soybean ubiquitin promoter are described. | 07-22-2010 |
| 20100184842 | Ultraconserved Regions Encoding ncRNAs - Described herein are methods for differentiate human cancers comprising using one or more transcribed ultraconserved regions (T-UCR) expression profiles where the association between the genomic location of UCRs and the analyzed cancer-related genomic elements is highly statistically significant and comparable to that reported for miRNAs. | 07-22-2010 |
| 20100184037 | DEATH ASSOCIATED PROTEIN KINASE 1 (DAPK1) AND USES THEREOF FOR THE TREATMENT OF CHRONIC LYMPOCYTIC LEUKEMIA - A method for determining susceptibility to chronic lymphocytic leukemia in a subject includes determining a loss or reduced expression of death associated protein kinase 1 (DAPK1) or fragments or functional equivalents thereof. | 07-22-2010 |
| 20100172843 | NANOPARTICULATE PROBE FOR IN VIVO MONITORING OF TISSUE OXYGENATION - A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro. | 07-08-2010 |
| 20100167947 | Polymorphisms in Genes Affecting Ace-Related Disorders and Uses Thereof - A method for predicting a subject's risk factors for ACE-related disorders includes detecting the allelic status of one or more polymorphisms in a nucleic acid sample of the subject. | 07-01-2010 |
| 20100152699 | Nanochanneled Device and Related Methods - A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel. | 06-17-2010 |
| 20100151487 | Hepcidins as Biomarkers for Impending Lupus Nephritis Flare - Biomarkers for determining a kidney flare episode in systemic lupus erythematosus are described. | 06-17-2010 |
| 20100144850 | Methods for Differentiating Pancreatic Cancer from Normal Pancreatic Function and/or Chronic Pancreatitis - There is provided herein methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer, along with methods of identifying anti-pancreatic cancer agents. | 06-10-2010 |
| 20100143921 | Polymorphisms in Genes Affecting Dopamine Transporter Disorders and Uses Thereof - A method for predicting a subject's risk factors for dopamine transporter or SLC6A3-related disorders. The method includes detecting the allelic status of one or more polymorphisms in a nucleic acid sample of the subject. The present invention also provides a related kit, comprising an assay for detecting the allelic status of one or more polymorphisms in a nucleic acid sample of a subject. | 06-10-2010 |
| 20100143500 | Methods and Compositions for Inhibiting GSK-3 In Glial Cell Related Disorders - A method of treating a glial cell related disorder in a mammalian subject includes administering a drug which enhances or prolongs GSK-3 α or β inactivation. | 06-10-2010 |
| 20100137410 | Oncogenic ALL-1 Fusion Proteins for Targeting Drosha-Mediated MicroRNA Processing - Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins. | 06-03-2010 |
| 20100129818 | Polymorphisms in Genes Affecting CYP2C9-Related Disorders and Uses Thereof - A method for predicting a subject's risk factors for CYP2C9-related disorders includes detecting the allelic status of one or more polymorphisms in a nucleic acid sample of the subject. | 05-27-2010 |
| 20100129289 | COMPOSITIONS AND METHODS FOR THE DETECTION OF VULNERABLE PLAQUE - Targeting polypeptide imaging agents, methods employing the agents, and kits employing the agents are provided. The targeting polypeptide imaging agents may have at least one targeting polypeptide and at least one contrast enhancing imaging agent. | 05-27-2010 |
| 20100120898 | MicroRNA Expression Signature for Predicting Survival and Metastases in Hepatocellular Carcinoma - Provided herein are methods and compositions for the diagnosis, prognosis and treatment of Hepatocellular carcinoma (HCC). Also provided are methods of identifying anti-HCC agents. | 05-13-2010 |
| 20100119569 | SYSTEMS FOR IMPROVING MATERIAL EXCHANGE WITH AN IMPLANT - A system for implanting a device within a biological target region for exchange of material with the biological target region is provided. The system includes an implantable device and a plurality of precursor cells. The implantable device has at least one recess on a first surface of the device, and a filter configured to allow communication between the at least one recess and an internal portion of the device. The at least one recess is configured to receive the precursor cells and to allow the cells to mature and convert into microvessels disposed along the recesses. | 05-13-2010 |
| 20100113940 | WOUND GOGGLES - Appropriate assessment of wound oxygenation is critical to establish a diagnosis, to monitor the effect of the treatment, to guide the therapeutic process, to identify the presence of infection, and to predict the treatment outcome. Embodied systems and methods represent an enabling technology for noninvasive and objective assessment of wound tissue oxygenation. In addition to wound healing, disclosed embodiments offer low cost and portable avenues for noninvasive assessment of multiple clinical parameters for the detection and intervention of various malignancies in multiple soft tissue systems. | 05-06-2010 |
| 20100099782 | SUSPENSION POLYMERIZATION AND FOAMING OF WATER CONTAINING ACTIVATED CARBON-NANO/MICROPARTICULATE POLYMER COMPOSITES - Synthesis of polystyrene and/or other thermoplastic polymers or polymer blends which, for example, contain activated carbon and/or bamboo carbon carrying a co-blowing agent such as water and/or at least one of 1-dimensional, 2-dimensional, and 3-dimensional nano/micro-materials in suspension polymerization without using the inverse emulsion process. CO | 04-22-2010 |
| 20100095740 | DETERMINING PHYSICAL PROPERTIES OF STRUCTURAL MEMBERS IN MULTI-PATH CLUTTER ENVIRONMENTS - A method for determining a physical property of an object in a multi-path clutter environment comprises transmitting an RF interrogation signal to a wireless sensor physically coupled to the object or the fluid in the multi-path clutter environment, wherein the wireless sensor is operable to receive the RF interrogation signal, produce a reference signal and a measurement signal, and transmit the reference signal and the measurement signal in the multi-path clutter environment. The reference signal and measurement signal are delayed by the wireless sensor by an amount of time that may be a function of the unknown physical property. The method also comprises receiving the transmitted reference signal and the transmitted measurement signal and comparing them in the time domain in order to determine the unknown physical property of the object or the fluid. | 04-22-2010 |
| 20100075308 | POLYMORPHISMS IN GENES AFFECTING CNS DISORDERS AND USES THEREOF - Diagnostic and prognostic methods, compositions, assays, and kits useful for predicting the phenotype of subjects who have, or are at risk of developing, a mental disorder. The methods also include predicting the prognostic outcome of a subject's mental disorder as well as the subject's responsiveness to drug treatments for the mental disorder. The methods and kits include determining the allelic status of polymorphisms in the MAOA, TPH2 and DRD2 genes. | 03-25-2010 |
| 20100074958 | METHODS AND COMPOSITIONS FOR TARGETING FENESTRATED VASCULATURE - Targeting of a fenestrated vasculature at a body site by micro or nanoparticles can be increased by using particles that have a radius substantially equal to a critical radius of a normal vasculature at the body site. The particles can be used for treating or monitoring a physiological condition responsible for the fenestrated vasculature. A method of improving an ability of micro or nanoparticles to target fenestrated blood vessels in a body site by selecting particles from a population of the micro or nanoparticles, where the selected particles have a radius that permits enhanced delivery into the fenestrated blood vessels. | 03-25-2010 |
| 20100071085 | System for Expression of Genes in Plants from a Virus-Based Expression Vector - Modified expression vectors, including Tobacco Mosaic Virus (TMV) expression vectors, methods for modifying such vectors, and uses of the same are disclosed. | 03-18-2010 |
| 20100049236 | METHOD FOR TESTING AN AGENT FOR STROKES IN HUMANS WITH A NON-HUMAN STROKE MODEL - An agent for treating strokes in humans is tested in a non-human subject by selecting an agent for testing and by preparing a selected non-human subject. The preparation includes: inducing a stroke event by advancing a microwire through the arterial system of the subject to a selected intracranial target position, inserting a microcatheter along the microwire and delivering an embolic device to the target position, occluding the artery at the target position by deploying the embolic device, verifying the occlusion and repositioning the embolic device if needed. After a predetermined occlusion interval, reperfusion of the subject is simulated by removing the embolic device and commencing therapy with the selected agent. At appropriate intervals, the effect of the conducted course of therapy is assessed non-invasively until terminal evaluation. In particular aspects, the method involves occluding the middle cerebral artery through an access achieved via the basilar artery. | 02-25-2010 |
| 20100048681 | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Acute Myeloid Leukemia (AML) - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). The invention also provides methods of identifying anti-AML agents. | 02-25-2010 |
| 20100035798 | METHODS AND COMPOSITIONS FOR THE TOPICAL OXYGENATION OF HYPOXIC TISSUE - The invention provides methods, delivery devices, and compositions for topically oxygenating hypoxic tissue with a hemoglobin-based oxygen earner (HBOC), such as Oxyglobin (Oxyb) in order to promote wound healing and/or reducing hypoxia in post-harvest transplant tissue. The invention can be used, among other things, to stimulate angiogenesis and blood flow at a wound site, reduce wound dilation, and promote wound contraction, thereby increasing the overall rate of wound healing. The invention can also be used, among other things, to reduce oxidative stress in pre-implantation donor organ tissue, as well as stimulate the proliferation of granulation tissue, vessel growth, and promote epithelial healing in transplant tissue once it has been implanted. | 02-11-2010 |
| 20100022655 | Therapeutic Agents For The Treatment Of Lymphoid Malignancies - Methods—for treatment and prevention of lymphoid malignancies, including, but not limited to acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), B-cell lymphoma, Acute Myeloid leukemia (AML), and mantle cell lymphoma (MCL). The methods include administration of a therapeutically effective amount of FTY720 (2-Amino-2-[2-(4-octylphenyl)ethyl]propane 1,3-diol hydrochloride) or a derivative, pharmaceutically acceptable salt thereof, or a prodrug thereof to a subject. | 01-28-2010 |
| 20100004322 | TCL1 Expression in Chronic Lymphocytic Leukemia (CLL) Regulated by MIR-29 and MIR-181 - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of chronic lymphocytic leukemia (CLL). The invention also provides methods of identifying anti-CLL agents. | 01-07-2010 |
| 20090315634 | EMULATION OF ANISOTROPIC MEDIA IN TRANSMISSION LINE - In one exemplary embodiment, a transmission line geometry or structure may readily be realized as periodic printed coupled/uncoupled microstrip lines on dielectric and/or suitable biased ferromagnetic substrates. An example of a transmission line geometry or structure may be adapted to emulate extraordinary propagation modes within bulk periodic assemblies of anisotropic dielectric and magnetic materials. For instance, wave propagation in anisotropic media may be emulated by using a pair of coupled transmission lines ( | 12-24-2009 |
| 20090291992 | ANDROGEN RECEPTOR-ABLATIVE AGENTS - Compounds of the thiazolidinedione family are provided and shown to be effective androgen receptor ablative agents that can be used in methods of treating or preventing cancer or precancer, including prostate cancer. Also provided are methods of treating or preventing cancer by administering a therapeutically effective amount of one of the androgen receptor ablative agents to a subject in need of such treatment. | 11-26-2009 |
| 20090286666 | LANTHANUM OXIDE-DOPED GLASS-CERAMICS - Glass-ceramic compositions exhibiting high reliability and tensile strength are described. The compositions can include crystal phases including roedderite and/or potassium fluorrichterite. The glass-ceramic compositions are bioactive, and can be used as components of a wide variety of biomedical devices such as dental restorations. | 11-19-2009 |
| 20090281328 | PDK-1/AKT SIGNALING INHIBITORS - A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I: | 11-12-2009 |
| 20090270484 | WWOX Vectors and Uses in Treatment of Cancer - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer in a subject, by administering to the subject a polynucleotide encoding a functional WWOX gene product. | 10-29-2009 |
| 20090263001 | SYSTEM AND METHOD FOR IMPROVED REAL-TIME CINE IMAGING - A cine imaging filter and method of use that includes a denoising image-filter based on the Karhunen-Loeve transform along the temporal direction to take advantage of the high temporal correlation among images. The cine imaging filter may further include the application of a simple formula describing the quantitative noise reduction capabilities of the KLT filter as a function of eigenimage cutoff. Additionally, the filter may validate its accuracy in numerical simulation and in in-vivo real time cine images. Furthermore, exemplary embodiments of the cine imaging filter may employ a technique to automatically select the optimal eigenimage cutoff to maximize noise reduction with minimal effect on image information. | 10-22-2009 |
| 20090253715 | HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS - Compounds and methods useful for treating and prevention of cancer, particularly hormone-dependent breast cancer. Provided are compounds of formula I: | 10-08-2009 |
| 20090235969 | TERNARY THERMOELECTRIC MATERIALS AND METHODS OF FABRICATION - A thermoelectric material and a method of fabricating a thermoelectric material are provided. The thermoelectric material includes a compound having an elemental formula of A | 09-24-2009 |
| 20090234225 | FLUORESCENCE DETECTION SYSTEM - Exemplary embodiments include systems, methods, and compositions for the intra-operative detection of target tissue. At least one embodiment includes a fluorescence detection instrument that may be used for intra-operative detection of a fluorescent targeting agent, its binding site, and its interaction within cancer tissues. An exemplary embodiment is highly sensitive to the local deposition of fluorescence agents even at a low concentration. In at least one embodiment, the system includes a handheld navigation instrument that is usable to excite, detect, and report the fluorescent deposition of the targeting agent in real-time. In alternative embodiments, the system includes a wearable unit to excite, detect, and visually report the fluorescent deposition of the targeting agent to the user. The wearable unit includes eyewear that allow the user to perform image-guided surgery based on the near real-time fluorescence detection of the fluorescent targeting agent. | 09-17-2009 |
| 20090207769 | METHOD AND APPARATUS FOR SCHEDULING TIMING FOR COMMUNICATION BETWEEN SENSOR NODES IN WIRELESS SENSOR NETWORK - Provided is a method of scheduling timing for communication between sensor nodes in a wireless sensor network, the method including categorizing a plurality of sensor nodes in a cluster into several groups, respectively assigning time slots to the groups, and establishing data communication according to the assigned time slots. | 08-20-2009 |
| 20090203631 | PEPTIDE DEFORMYLASE INHIBITORS AS NOVEL ANTIBIOTICS - A macrocyclic peptide deformylase (PDF) inhibitor comprising a peptide or peptide mimetic having three residues, P | 08-13-2009 |
| 20090191234 | VACCINE - This invention relates to three newly-identified, distinct groups of antigenic peptides [LB1(f) peptides] from the same region of the P5-like fimbrin protein discovered using sequence data from the fimbrin protein of many | 07-30-2009 |
| 20090181110 | Compositions from Garcinia as Aromatase Inhibitors for Breast Cancer Chemoprevention and Chemotherapy - Aromatase inhibitors (AIs) are disclosed which are useful in the treatment and prevention of post-menopausal breast cancer. New AIs derived from natural products are disclosed that are evaluated for clinical utility for treating post-menopausal breast cancer and may also act as chemopreventive agents for preventing breast cancer. Several pure compounds demonstrated AI activity using a noncellular, enzyme-based microsomal and a cell-based aromatase assay. Correlations are made between structural classes with levels of aromatase inhibition. The disclosure may be utilized to direct synthetic modification of natural product scaffolds to enhance aromatase inhibition or to standardize botanical dietary supplements for increased aromatase inhibition activity. | 07-16-2009 |
| 20090178700 | THERMOELECTRIC FIGURE OF MERIT ENHANCEMENT BY MODIFICATION OF THE ELECTRONIC DENSITY OF STATES - A thermoelectric material and a method of fabricating a thermoelectric material are provided. The thermoelectric material includes a doped compound of at least one Group IV element and at least one Group VI element. The compound is doped with at least one dopant selected from the group consisting of: at least one Group Ia element, at least one Group IIb element, at least one Group IIIa element, at least one Group IIIb element, at least one lanthanide element, and chromium. The at least one Group IV element is on a first sublattice of sites and the at least one Group VI element is on a second sublattice of sites, and the at least one Group IV element includes at least 95% of the first sublattice sites. The compound has a peak thermoelectric figure of merit ZT value greater than 0.7 at temperatures greater than 500 K. | 07-16-2009 |
| 20090168301 | Functionalized Nanotube Material for Supercapacitor Electrodes - The present teachings are directed towards supercapacitors including an electrode composed of a functionalized carbon nanotube-containing material, and also an organic electrolyte solution. The organic electrolyte solution can contain a non-aqueous solvent and an ionic salt, examples of non-aqueous solvent include propylene carbonate, ethylene carbonate, sulfolane and acetonitrile. The functional groups present on the carbon nanotubes can include hydroxyl groups, carboxyl groups, alkoxyl groups and mixtures thereof. | 07-02-2009 |
| 20090162852 | BAALC EXPRESSION AS A DIAGNOSTIC MARKER FOR ACUTE LEUKEMIA - Overexpression of the gene, BAALC, in biological samples from a patient is prognostic for tumor aggressiveness and unfavorable patient outcome. The present invention provides polynucleotide primers and probes for assaying for overexpression of BAALC transcripts. Kits containing the primers and probes are also provided. Also provided are antibodies for assaying for overexpression of BAALC proteins as well as peptide immunogens for producing the anti-BAALC antibodies. The present invention also provides methods for characterizing acute myelogenous leukemia, chronic myelogenous leukemia and prostate cancer in a patient, base on detection of BAALC overexpression. | 06-25-2009 |
| 20090155779 | APTAMERS THAT BIND TO PRION PROTEIN - Compositions are provided in the form of nucleotide aptamerss that are capapble of binding PrP, and in some embodiments, differentially binding PrP isoforms. Also provided are methods for identifying PrP in a sample, and in some embodiments, either selectively removing PrP or PrP isoforms from a sample, or inactivating them within a sample. | 06-18-2009 |
| 20090151014 | SOYBEAN CULTIVAR HFPR-5 - A soybean cultivar designated HFPR-5 is disclosed. The invention relates to the seeds of soybean cultivar HFPR-5, to the plants of soybean HFPR-5, to plant parts of soybean cultivar HFPR-5 and to methods for producing a soybean plant produced by crossing soybean cultivar HFPR-5 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars or breeding cultivars and plant parts derived from soybean variety HFPR-5, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar HFPR-5 and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants and plant parts produced by crossing the cultivar HFPR-5 with another soybean cultivar. | 06-11-2009 |
| 20090137679 | ZN2+Chelating Motif-Tethered Short-Chain Fatty Acids as a Novel Class of Histone Deacetylase Inhibitors | 05-28-2009 |
| 20090123917 | METHODS FOR QUANTIFYING MICRORNA PRECURSORS - Provided herein is a sensitive, high throughput, real-time PCR assay to monitor the expression of miRNA precursors. Gene specific primers and reverse transcriptase were used to convert the primary precursors and pre-miRNAs to cDNA. The expression of 23 miRNA precursors in six human cancer cell lines was assayed using the PCR assay. The miRNA precursors accumulated to different levels when compared to each other or when a single precursor is compared in the various cell lines. The precursor expression profile of three miRNAs determined by the PCR assay was identical to the mature miRNA expression profile determined by Northern blotting. We propose that the PCR assay may be scaled up to include all of the 150+ known human miRNA genes and can easily be adaptable to other organisms such as plants, | 05-14-2009 |
| 20090123336 | MICROFLUIDIC CHIPS FOR RAPID MULTIPLEX ELISA - A microfluidic chip comprises a substrate and a channel or multiple channels in the substrate. Each channel includes a tortuous path section or multiple tortuous path sections. A receptor for the detection of an analyte can be immobilized in a tortuous path section, for example by adsorption. Different receptors can be immobilized in different tortuous path sections of each channel or in different channels for simultaneous detection of multiple analytes. The chip is especially useful for running immunoassays, particularly ELISA. | 05-14-2009 |
| 20090117557 | Rapid Detection of Microorganisms - Tools and methods for detecting the presence bacteria, yeast and mold in a sample obtained from a food sample are provided. The methods employ a polymerase chain reaction and primer and probe sets that are based on the 16S rRNA and squalene-hopene cyclase genes of | 05-07-2009 |
| 20090117542 | UNIQUE SHORT TANDEM REPEATS AND METHODS OF THEIR USE - Methods for DNA fingerprinting identification of human DNA samples, comprising: a) exposing a DNA sample of an individual to at least one primer specific for a Y chromosome polymorphism at a predetermined loci, said loci being chosen from OSU9, OSU14, OSU22, OSU35, OSU51, OSU57, OSU67, OSU70, OSU73, OSU77, with the proviso that if OSU70 is selected then at least one other OSU locus is also selected; b) amplifying DNA of the DNA sample using the at least one primer specific for a Y chromosome polymorphism; and c) identifying the size of an amplified product. Primers for the methods are also provided. | 05-07-2009 |
| 20090111799 | ANTI-INFECTIVE AGENTS AGAINST INTRACELLULAR PATHOGENS - A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: | 04-30-2009 |
| 20090110292 | Hand Sign Recognition Using Label Assignment - A method and system for recognizing hand signs that include overlapping or adjoining hands from a depth image. A linked structure comprising multiple segments is generated from the depth image including overlapping or adjoining hands. The hand pose of the overlapping or adjoining hands is determined using either (i) a constrained optimization process in which a cost function and constraint conditions are used to classify segments of the linked graph to two hands or (ii) a tree search process in which a tree structure including a plurality of nodes is used to obtain the most-likely hand pose represented by the depth image. After determining the hand pose, the segments of the linked structure are matched with stored shapes to determine the sign represented by the depth image. | 04-30-2009 |
| 20090090162 | Driver plate for electromagnetic forming of sheet metal - A multi-layer driver plate is disclosed for use in electromagnetic sheet metal forming operations. In one embodiment, the driver plate comprises a first layer characterized by low electrical resistivity and thickness for inducement and application of a suitable electromagnetic forming force, a second layer comprising an elastomeric material for compressing a sheet metal workpiece against a die surface and then regaining its original pre-forming structure, and a third layer interposed between the first layer and the second layer to protect the EMF force providing layer and to provide overall strength and durability to the EMF driver plate. | 04-09-2009 |
| 20090075368 | Outer membrane protein of Ehrlichia canis and Ehrlichia chaffeensis - Diagnostic tools for serodiagnosing ehrlichiosis in mammals, particularly in members of the Canidae family and in humans are provided. The diagnostic tools are a group of outer membrane proteins of | 03-19-2009 |
| 20090048265 | NOVEL ANTITUMOR AGENTS AND METHODS OF THEIR USE - Antitumor compounds based on the α1-adrenoceptor antagonist, doxazosin, as well as compositions and methods of use. The disclosed compounds induce apoptosis in cancer cells. | 02-19-2009 |
| 20090020748 | SI/SIGE INTERBAND TUNNELING DIODES WITH TENSILE STRAIN - Some disclosed interband tunneling diodes comprise a plurality of substantially coherently strained layers including layers selected from a group consisting of silicon, germanium, and alloys of silicon and germanium, wherein at least one of said substantially coherently strained layers is tensile strained. Some disclosed resonant interband tunneling diodes comprise a plurality of substantially coherently strained layers including layers selected from a group consisting of silicon, germanium, and alloys of silicon and germanium, wherein at least one of said substantially coherently strained layers defines a barrier to non-resonant tunnel current. Some disclosed interband tunneling diodes comprise a plurality of substantially coherently strained layers, wherein at least one of said substantially coherently strained layers is tensile strained. Some disclosed resonant interband tunneling diodes comprise a plurality of substantially coherently strained layers, wherein at least one of said substantially coherently strained layers defines a barrier to non-resonant tunnel current. | 01-22-2009 |
| 20090011407 | Polymorphic Cd24 Genotypes that are Predictive of Multiple Sclerosis Risk and Progression - An image data correction apparatus has a motion information acquisition section, a correction section, and a composition section. The motion information acquisition section acquires motion information indicating spatial distribution of the magnitude of motion, in actual space, of a to-be-imaged portion of a subject. Based on the motion information, the correction section performs correction, which is different from correction in a second region, in a first region of image data collected by a scan by magnetic resonance imaging. The composition section composes individual image data of the first region and the second region that are corrected by the correction section. | 01-08-2009 |
| 20090010956 | EHRLICHIA EWINGII PROTEINS, NUCLEIC ACIDS, AND METHODS OF THEIR USE - The novel omp-1 gene cluster encoding twenty one | 01-08-2009 |
| 20090004182 | Methods to Treat or Prevent Viral-Associated Lymphoproliferative Disorders - The disclosure relates to methods to prevent, treat, or slow the progression viral-associated lymphoproliferative disorders, EBV-associated lymphoproliferative disorders, and post-transplant lymphoproliferative disorders. In the methods, a TGF-β antagonist, e.g., an anti-TGF-β antibody is administered to a subject. Methods for treating viral-associated lymphoproliferative disorders and for enhancing T-cell responsiveness to a viral-associated lymphoproliferative disorder by administering a TGF-β antagonist are also described. | 01-01-2009 |
| 20080300291 | POTENT INDOLE-3-CARBINOL-DERIVED ANTITUMOR AGENTS - Compounds and methods for treating cancer and inducing apoptosis in unwanted rapidly proliferating cells. The compounds are shown in formula I: | 12-04-2008 |
| 20080277578 | Nanoporous substrates for the analytical methods - Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range. | 11-13-2008 |
| 20080274457 | METHODS FOR DIFFERENTIATING MALIGNANT FROM BENIGN THYROID TISSUE - Methods of identifying malignant thyroid tissue comprising testing a thyroid tissue sample for the expression of at least two genes chosen from CCND2, PCSK2, and PLAB. Kits for use in the disclosed methods are also provided. | 11-06-2008 |
| 20080269309 | PDK-1/AKT SIGNALING INHIBITORS - Use of a new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I for inducing apoptosis in unwanted rapidly proliferating cells, for treating, inhibiting, or delaying the onset of cancer, and for preventing restenosis in a subject that has undergone an angioplasty or stent: | 10-30-2008 |
| 20080249085 | Maytansinoid Analogs as Antitumor Agents - Ansamycin analogs, including maytansinoid analogs, and their use in treating cell proliferative diseases and conditions, and in particular, for use as antitumor agents. | 10-09-2008 |
| 20080248575 | Drug and Gene Delivery by Polymer Nanonozzle and Nanotip Cell Patch - Delivery of drugs or genes to individual cells is achieved on a nanoscale using electroporation techniques. In one method, a flow-through bioreactor having an inlet and an outlet connected by a flow chamber and a nanoporous membrane positioned in the flow chamber is used. Cells to be electroporated are flowed from the inlet to the outlet, a quantum of molecules of the at least one drug or gene in a fluid medium in the flow chamber. An electrical field applied in the flow chamber provides momentum to the molecules in the nanopores, resulting in delivery of the molecules into the plurality of cells. | 10-09-2008 |
| 20080235829 | TRANSGENIC PLANTS WITH ALTERED LEVELS OF PHENOLIC COMPOUNDS - Methods for altering levels in plants of one or more phenolic compounds that are intermediates or final products of the plant phenylpropanoid pathway are provided. One method comprises transforming a plant cell with an expression construct comprising a nucleic acid which encodes a transactivator protein comprising the myb domain of the maize “ZmMyb-IF35” protein and an activation domain. Another method comprises transforming a plant cell with an expression construct comprising a transgene which encodes an antisense ZmMyb-IF35 RNA. The present invention also relates to expression constructs and vectors used in the present methods, transformed plant cells and transgenic plants prepared according to the present methods, and the seeds of such transgenic plants. | 09-25-2008 |
| 20080206205 | Cd34(+) Cells And Their Methods Of Use | 08-28-2008 |
