| THE JOHNS HOPKINS UNIVERSITY Patent applications |
| Patent application number | Title | Published |
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| 20120136284 | ACTIVE HAND-EXTENSION/FLEXION DEVICE - A hand movement device comprises a glove for positioning about a hand of a user, a first anchor element adapted to be positioned about a base surface of glove, a second anchor element adapted to be positioned at a tip of a finger portion of the glove, an active spring member positioned between the first and second anchor elements, said active spring member being fixedly secured to said first anchor element and moveable through said second anchor element to thereby allow said spring member to bend about a joint of the finger when said finger is flexed, an activating element positioned adjacent the active spring member to heat or cool said active spring member thereby causing the spring member to bend or straighten, and an intermediary support device for housing said spring element and for connecting the first anchor element to said second anchor element. | 05-31-2012 |
| 20120135874 | SINGLE MOLECULE SPECTROSCOPY FOR ANALYSIS OF CELL-FREE NUCLEIC ACID BIOMARKERS - The present invention relates, e.g., to a method for detecting a nucleic acid molecule of interest in a sample comprising cell-free nucleic acids, comprising fluorescently labeling the nucleic acid molecule of interest, by specifically binding a fluorescently labeled nanosensor or probe to the nucleic acid of interest, or by enzymatically incorporating a fluorescent probe or dye into the nucleic acid of interest, illuminating the fluorescently labeled nucleic acid molecule, causing it to emit fluorescent light, and measuring the level of fluorescence by single molecule spectroscopy, wherein the detection of a fluorescent signal is indicative of the presence of the nucleic acid of interest in the sample. | 05-31-2012 |
| 20120135237 | SELF-ASSEMBLY OF LITHOGRAPHICALLY PATTERNED POLYHEDRAL NANOSTRUCTURES AND FORMATION OF CURVING NANOSTRUCTURES - The self-assembly of polyhedral nanostructures having at least one dimension of about 100 nm to about 900 nm with electron-beam lithographically patterned surfaces is provided. The presently disclosed three-dimensional nanostructures spontaneous assemble from two-dimensional, tethered panels during plasma or wet chemical etching of the underlying silicon substrate. Any desired surface pattern with a width as small as fifteen nanometers can be precisely defined in all three dimensions. The formation of curving, continuous nanostructures using extrinsic stress also is disclosed. | 05-31-2012 |
| 20120130258 | PROGRAMMABLE MULTIPSPECTRAL ILLIUMINATION SYSTEM FOR SURGERY AND VISUALIZATION OF LIGHT-SENSITIVE TISSUES - An observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a portion of the light-sensitive tissue upon being illuminated by the illumination system, and an image display system in communication with the imaging system to display an image of the portion of the light-sensitive tissue. The illumination system is configured to illuminate the light-sensitive tissue with a reduced amount of light within a preselected wavelength range compared to multispectral illumination light, and the image of the portion of the light-sensitive tissue is compensated for the reduced amount of light within the preselected frequency range to approximate an image of the light-sensitive tissue under the multispectral illumination | 05-24-2012 |
| 20120129206 | METHOD OF IDENTIFYING PATIENTS SUITABLE FOR HIGH-DOSE CYCLOPHOSPHAMIDE TREATMENT - The present invention provides methods of identifying subjects that are suitable for high-dose cyclophosphamide treatment. | 05-24-2012 |
| 20120128782 | Multicomponent Degradable Cationic Polymers - Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE | 05-24-2012 |
| 20120128685 | USE OF HIGH-DOSE OXAZAPHOSPHORINE DRUGS IN COMBINATION WITH MONOCLONAL ANTIBODIES FOR TREATING IMMUNE DISORDERS - The present invention relates to methods of treating an autoimmune disorder, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an oxazaphosphorine drug in combination with immune therapeutics such as, for example, monoclonal antibodies that selectively bind B-cell specific antigens. | 05-24-2012 |
| 20120128223 | METHOD AND SYSTEM FOR PROCESSING ULTRASOUND DATA - A method of processing ultrasound data includes receiving ultrasound data for a first ultrasound image, the first ultrasound image being represented as a first set of discrete pixels corresponding to positions of a region of interest; receiving ultrasound data for a second ultrasound image, the second ultrasound image being represented as a second set of discrete pixels corresponding to positions of the region of interest; generating a displacement map by minimizing a cost function using a dynamic programming procedure that identifies each of the first set of discrete pixels with a corresponding one of the second set of discrete pixels; refining the displacement map to obtain intermediate displacement values corresponding to positions between the discrete pixels based on minimizing a local approximation to the cost function; and calculating a physical property of the region of interest based on the displacement map. | 05-24-2012 |
| 20120124470 | AUDIO DISPLAY SYSTEM - An audio display system includes a pointing device configured to address locations within an interaction field, a sound system adapted to communicate with the pointing device, and—an object mapping unit adapted to communicate with the sound system. The object mapping unit is configured to generate a map identifying locations within the interaction field that correspond to a representation of an object to be displayed such that the interaction field is segmented into an exterior region and an interior region of the representation of the object. The sound system is configured to provide an object-locating sound when the pointing device addresses a location in the exterior region so as to guide a user to further address the interaction field at least one of closer to or further away from the interior region of the object. | 05-17-2012 |
| 20120122761 | METHODS FOR DETECTING A POLYMORPHISM IN THE NFKB1 GENE PROMOTER - The present invention discloses a functional relationship between a recognized disease condition and a polymorphism in the nucleotide factor kappa B promoter (NFKB1). This relationship provides a platform for methods of altering promoter activity and for determining similar relationships between specific pathologies and identified polymorphisms. A statistically significant risk of developing ulcerative colitis was shown to be correlated with the presence of an ATTG insertion/deletion in the NFKB1 promoter and is likely to apply also to a variety of other inflammatory diseases. | 05-17-2012 |
| 20120118297 | NASALLY INSERTED AIRWAY OPENING DEVICE FOR OBSTRUCTIVE SLEEP APNEA TREATMENT - A nasally inserted airway opening device with inflatable cuff is provided to treat obstructive sleep apnea. The airway opening device includes a hollow flexible tube extending between a proximal end and a distal end, and an inflatable cuff attached to the tube at or near the distal end. The inflatable cuff may be inflated and deflated via the tube. The inflatable cuff defines an interior through hole extending along the length thereof. When deflated, the inflatable cuff may be packed closely to the tube and may be inserted or removed through a nostril of a user. When inserted through the user's nostril and positioned in the user's oropharynx or naso-oropharynx and inflated, the inflatable cuff prevents soft tissue in the user's naso-oropharynx from collapsing toward the posterior pharyngeal wall while simultaneously allowing airflow through the through hole. A method for utilizing the airway opening device to prevent/treat sleep apnea is also provided. | 05-17-2012 |
| 20120118286 | NASAL AIRWAY MANAGEMENT DEVICE - An airway management device including a hollow flexible tube. The tube defines a lumen extending between a proximal end and a distal end. The proximal end is configured to be coupled to a ventilator and/or anesthesia circuit. An opening is provided at or near the distal end to allow passage of air and/or anesthesia therethrough. The tube is configured to be expanded radially after insertion through a patient's nasopharyngeal passageway when the distal end of the tube is positioned proximate the patient's hypopharynx. The device may include an inflatable outer sleeve surrounding and extending along the length of the tube. When the outer sleeve is in a deflated state, the distal end of the tube may be inserted through a patient's nasopharyngeal passageway. When the distal end of the tube is positioned proximate the patient's hypopharynx, the outer sleeve may be inflated and expanded. The device may include an inflatable cuff attached at or near the distal end of the tube and including an opening fluidly coupled with the opening and lumen of the tube to allow passage of air and/or anesthesia therethrough. When in a deflated state, the inflatable cuff may be inserted through the patient's nasopharyngeal passageway. When in an inflated state, the inflatable cuff may expand to form a seal around the patient's supraglottic laryngeal inlet. An intermediate inflatable cuff having a larger diameter than other portions of the outer sleeve when inflated may be positioned along the length of the tube between the proximal and distal ends. The respective inflatable elements of the device may be concurrently or separately inflatable. | 05-17-2012 |
| 20120116685 | Methods, System, And Medium For Associating Rheumatoid Arthritis Subjects With Cardiovascular Disease - The present invention relates to a system and a medium for analyzing one or more analytes in rheumatoid arthritis subjects to determine whether the subject is at increased risk of diseases such as a cardiovascular disease, the subject's current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in the subject. In addition, the present invention further provides methods for analyzing data to determine risk of cardiovascular disease, current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in a rheumatoid arthritis subject. | 05-10-2012 |
| 20120115835 | METHODS FOR TREATMENT OF BACTERIAL INFECTIONS - The peptidoglycan layer is a vital component of the bacterial cell wall, which comprises 4→3 and 3→3 transpeptide cross-linkages, the formation of which are catalyzed by D,D- and L,D-transpeptidases, respectively. Methods for the treatment of bacterial infections with agents that inhibit L,D-transpeptidases, either alone or in combination with D,D-transpeptidase inhibitors, are provided herein. Also provided are methods for the treatment of chronic stage tuberculosis with agents that inhibit enzyme with L,D-transpeptidase activity. | 05-10-2012 |
| 20120115735 | Pathways Underlying Pancreatic Tumorigenesis and an Hereditary Pancreatic Cancer Gene - There are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a comprehensive analysis of the genes altered in 24 pancreatic tumors. First, we determined the sequences of 23,781 transcripts, representing 20,583 protein-encoding genes, in DNA from these tumors. Second, we searched for homozygous deletions and amplifications using microarrays querying ˜one million single nucleotide polymorphisms in each sample. Third, we analyzed the transcriptomes of the same samples using SAGE and next-generation sequencing-by-synthesis technologies. We found that pancreatic cancers contain an average of 63 genetic alterations, of which 49 are point mutations, 8 are homozygous deletions, and 6 are amplifications. Further analyses revealed a core set of 12 regulatory processes or pathways that were each genetically altered in 70% to 100% of the samples. The data suggest that dysregulation of this core set of pathways is responsible for the major features of pancreatic tumorigenesis. | 05-10-2012 |
| 20120114759 | PEPTIDE/PARTICLE DELIVERY SYSTEMS - Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed. | 05-10-2012 |
| 20120109202 | INTERSEGMENTAL MOTION PRESERVATION SYSTEM FOR USE IN THE SPINE AND METHODS FOR USE THEREOF - Medical devices and kits for dynamically stabilizing or preserving motion in a spine and limiting adjacent, non-adjacent, or isolated segment degeneration of the spine while providing a controlled, determinable range of motion at the treated site, as well as methods for surgical use of the system. | 05-03-2012 |
| 20120109201 | INTERSEGMENTAL MOTION PRESERVATION SYSTEM FOR USE IN THE SPINE AND METHODS FOR USE THEREOF - Medical devices and kits for dynamically stabilizing or preserving motion in a spine and limiting adjacent, non-adjacent, or isolated segment degeneration of the spine while providing a controlled, determinable range of motion at the treated site, as well as methods for surgical use of the system. | 05-03-2012 |
| 20120108654 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR OXIDATIVE STRESS AND RETINITIS PIGMENTOSA - Oxidative damage contributes to cone cell death in retinitis pigmentosa and death of rods, cones, and retinal pigmented epithelial (RPE) cells in ocular oxidative stress related diseases including age-related macular degeneration and retinitis pigmentosa. Oral antioxidants may provide modest benefits, but more efficient ways of preventing oxidative damage are needed. Compositions and methods are provided herein for the prevention, amelioration, and/or treatment of early or late stage ocular disease by increasing the expression or activity of one or more peroxidases in cells of the eye, particularly retinal cells, and further optionally increasing the expression or activity of one or more superoxide dismuatases in the same cells. | 05-03-2012 |
| 20120108545 | Trioxane Monomers and Dimers - Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, toxoplasmic infection; subjects afflicted with psychiatric conditions associated with toxoplasmic infection; and subjects afflicted with cancer. | 05-03-2012 |
| 20120107184 | DECONTAMINATION APPARATUS - A decontamination apparatus is provided including an enclosure. A first and second decontamination system may be provided within the enclosure. The first and second decontamination systems may be arranged within the enclosure and configured to decontaminate the articles received in the enclosure. The first and second decontamination systems may rely on different methods of decontamination. The enclosure of the decontamination apparatus may be defined by a plurality of connected prefabricated modular walls. A mobile control and supply module may also be provided. | 05-03-2012 |
| 20120101022 | SELF-ASSEMBLING PEPTIDES BEARING ORGANIC ELECTRONIC FUNCTIONALITY AND APPLICATIONS EMPLOYING THE SAME - The aqueous self-assembly of oligopeptide-flanked π-conjugated molecules into discrete one-dimensional nanostructures is described. Unique to these molecules is the fact that the π-conjugated unit has been directly embedded within the peptide backbone by way of a synthetic amino acid with π-functionality that is compatible with standard Fmoc-based peptide synthesis or by way of a diacid or other bis(electrophile) that can covalently cross-link peptide chains presented on a synthesis support. The peptide-based molecular designs enforce intimate π-π communication within the aggregates after charge-screening and self-assembly, making these nanostructures attractive for optical or electronic applications in biological environments. In other embodiments, a convenient method to incorporate π-electron units into peptides that assemble into amyloid-like supramolecular polymers is disclosed. Self-assembly manipulates these “electronic peptides” into delocalized sub-10 nm one dimensional (1-D) nanostructures under completely aqueous conditions. | 04-26-2012 |
| 20120100560 | DEVICE FOR CAPTURE, ENUMERATION, AND PROFILING OF CIRCULATING TUMOR CELLS - Applications in nanomedicine, such as diagnostics and targeted therapeutics, rely on the detection and targeting of membrane biomarkers. The present invention, in one embodiment, utilizes quantitative profiling, spatial mapping, and multiplexing of cancer biomarkers using functionalized quantum dots. This approach provides highly selective targeting molecular markers for pancreatic cancer with extremely low levels of non-specific binding and provides quantitative spatial information of biomarker distribution on a single cell, which is important since tumors cell populations are inherently heterogeneous. The quantitative measurements (number of molecules per square micron) is validated using flow cytometry and demonstrated using multiplexed quantitative profiling using color-coded quantum dots. | 04-26-2012 |
| 20120100162 | Cyclophosphamide in Combination with Immune Therapeutics - The present invention relates to methods of treating a cancer and in particular, a B-cell derived cancer, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an oxazaphosphorine drug, either alone, or in combination with immune therapeutics such as, for example, monoclonal antibodies that selectively bind B-cell specific antigens. | 04-26-2012 |
| 20120095086 | PROTEIN TYROSINE PHOSPHATASE MUTATIONS IN CANCERS - Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (PTPs) and kinases (PTKs), is important in signaling pathways underlying tumorigenesis. A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mutations in six PTPs (PTPRF, PTPRG, PTPRT, PTPN3, PTPN13, PTPN14), affecting 26% of colorectal cancers and a smaller fraction of lung, breast and gastric cancers. Fifteen mutations were nonsense, frameshift or splice site alterations predicted to result in truncated proteins lacking phosphatase activity. Five missense mutations in the most commonly altered PTP (PTPRT) were biochemically examined and found to reduce phosphatase activity. Expression of wild-type but not a mutant PTPRT in human cancer cells inhibited cell growth. These observations suggest that the tyrosine phosphatase genes are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention. | 04-19-2012 |
| 20120094295 | NEURODEGENERATIVE DISEASE DIAGNOSTIC COMPOSITIONS AND METHODS OF USE - The invention generally provides diagnostics that employ biomarkers altered in neurodegenerative disease, as well as methods for the use of such markers in monitoring disease progression and identifying agents useful for the treatment of a neurodegenerative disease. | 04-19-2012 |
| 20120093724 | METHODS AND COMPOSITIONS FOR THE DETECTION OF CANCER - Various embodiments of this invention relate generally to targeted activation and delivery of therapeutic drugs to cells that produce prostate specific antigen (PSA), prostate specific membrane antigen (PSMA) or human glandular kallikrein (hK2). Various further embodiments relate more specifically to PSMA-specific peptide prodrugs that become activated to yield therapeutic drugs. Further aspects of various embodiments of the present invention also relate to methods and compositions for treating or preventing cancers and methods and compositions for detecting and/or imaging cancers. | 04-19-2012 |
| 20120088812 | COMPOSITIONS FOR PROMOTING EPIGENETIC DNA DEMETHYLATION AND METHODS OF USE THEREFORE - The invention features compositions and methods for modulating the expression of Gadd45 and the use of such compositions and methods as neuroprotectants, to enhance neurogenesis, and for the treatment of mood disorders. | 04-12-2012 |
| 20120083767 | IMPLANTABLE BIOREACTOR FOR DELIVERY OF PARACRINE FACTORS - An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. Bioreactors of both classes can be implanted via surgery, through percutaneous techniques, or other techniques which effect implantation. | 04-05-2012 |
| 20120077763 | METHODS FOR TREATING HEART FAILURE BY INHIBITING THE MITOCHONDRIAL SODIUM-CALCIUM EXCHANGER (mNCE) - Methods and compounds for preventing or reducing the toxic side effects of cardiac glycosides by inhibiting the mitochondrial sodium-calcium exchanger (mNCE) are provided. Methods and compositions for preventing or reducing the occurrence of conditions associated with heart failure, including, but not limited to, sudden cardiac death and contractile decompensation, by inhibiting the mNCE also are provided. | 03-29-2012 |
| 20120076811 | IMMUNODOMINANT COMPOSITIONS AND METHODS OF USE THEREFOR - The present invention relates to immunodominant compositions, including immunodominant peptides of HA1 of influenza H5 hemagglutinin, polynucleotides encoding such peptides, and their methods of use. Such peptides are useful, for example, for the prevention, treatment and diagnosis of influenza. | 03-29-2012 |
| 20120076752 | Mesothelin Vaccines and Model Systems - Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line. | 03-29-2012 |
| 20120076681 | PNEUMATIC STEPPER MOTOR - A stepper motor suitable for use in a medical imaging environment has (a) a cylindrical central gear having an external surface with circumferentially distributed and radially directed teeth, (b) a shaft for mounting the central gear such that it is constrained to move in rotational motion about its centerline, (c) a cylindrical hoop gear having a bore with an internal surface having circumferentially distributed and radially directed teeth, (d) level arm crank mechanisms for mounting the hoop gear such that it is constrained to move in translational-circular motion about the central gear's centerline, wherein this central gear is further configured to fit within the hoop gear's bore in such a manner that a plurality of the central gear and hoop gear teeth intermesh and cooperate so that the planetary movement of the hoop gear causes the central gear to rotate, and (e) piston mechanisms for applying a fluid pressure driven force to specified points on the hoop gear so as to cause its movement. | 03-29-2012 |
| 20120073001 | METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS - The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents. | 03-22-2012 |
| 20120071890 | METHOD AND APPARTUS FOR COCHLEAR IMPLANT SURGERY - A system for cochlear implant surgery includes a reference device having at least a portion adapted to be arranged at a fixed position relative to a cochlea of a patient to provide a reference position, an image acquisition and processing system adapted to acquire an image of at least a portion of the cochlea relative to the reference position and to provide an implant plan based at least partially on the acquired image, and an implant system adapted for implanting a cochlear lead array using the reference position and the implant plan. | 03-22-2012 |
| 20120065549 | APPARATUS AND METHOD FOR ASSESSING VESTIBULO-OCULAR FUNCTION - A system for assessing vestibulo-ocular function includes a motion sensor system adapted to be coupled to a user's head; a data processing system configured to communicate with the motion sensor system to receive the head-motion signals; a visual display system configured to communicate with the data processing system to receive image signals from the data processing system; and a gain control device arranged to be operated by the user and to communicate gain adjustment signals to the data processing system. | 03-15-2012 |
| 20120065470 | ROBOTIC SYSTEM TO AUGMENT ENDOSCOPES - A robotic system for steerable tip endoscopes includes a support arm, an endoscope gripping assembly rotatably connected to the support arm by a rotation assembly, and a translation assembly operatively connected to the support arm. The endoscope gripping assembly is configured to grip any one of a plurality of differently structured endoscopes, the translation assembly is configured to move the support arm along a linear direction to thereby move an endoscope when held by the endoscope gripping assembly along an axial direction, and the rotation assembly is configured to rotate the endoscope along a longitudinal axis of rotation. | 03-15-2012 |
| 20120065026 | LOW PROFILE HAND-EXTENSION/FLEXION DEVICE - A movement device for flexing and/or straightening a joint of a user includes a first anchor element adapted to be positioned adjacent a jointed appendage of a user at a first position. A second anchor element is adapted to be positioned about the jointed appendage at a second position, wherein the jointed appendage is located between the first anchor element and the second anchor element. A spring member is positioned between the first and second anchor elements wherein the spring member is fixedly secured to the second anchor element and moveable through the first anchor element to thereby allow the spring member to bend about a joint of the appendage when said appendage is flexed. The spring member is configured to exert bending forces in opposition to working muscles of the user to straighten or flex the joint of the appendage. To minimize discomfort, an intermediary support device is disposed between the first anchor element and the second anchor element which prevents the spring member from contacting the joint of the user. | 03-15-2012 |
| 20120063689 | OBJECT RECOGNITION IN AN IMAGE - A method of identifying an object in an image includes selecting a portion of a target image of a target object, selecting a corresponding window portion of a reference image of a reference object from at least one reference image of at least one reference object, the position of the window portion within the reference image corresponding to the position of the portion of the target image within the target image, generating a reference set including a plurality of different portions of the reference image from within the window portion, determining a weighted combination of the plurality of different portions from the reference set approximating the portion of the target image, and determining whether the target object matches the reference object based on the weighted combination. | 03-15-2012 |
| 20120062227 | METHOD FOR MAGNETIC RESONANCE IMAGING USING INVERSION RECOVERY WITH ON-RESONANT WATER SUPPRESSION INCLUDING MRI SYSTEMS AND SOFTWARE EMBODYING SAME - Featured are methods for magnetic resonance imaging of a volume, such a volume having susceptibility-generating objects or interfaces having susceptibility mismatches therein. Such a method includes selectively visualizing one of susceptibility-generating objects or interfaces having susceptibility mismatches as hyperintense signals, where such visualizing includes controlling variable imaging parameters so as to control a geometric extent of a signal enhancing effect, m more particular aspects of the present invention, such selectively visualizing includes attenuating or essentially suppressing signals from fat and/or water, namely on-resonant water protons, so as to thereby enhance a signal(s) associated with magnetic susceptibility gradient(s). Also featured are MRI systems, apparatuses and/or applications programs for execution on a computer system controlling the MRI data acquisition process embodying such methods. | 03-15-2012 |
| 20120046336 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION - This invention relates to treating age-related cognitive impairment. This invention in particular relates to the use of inhibitors of synaptic vesicle protein 2A (SV2A), such as levetiracetam, seletracetam, and brivaracetam, in improving cognitive function in subjects that exhibit age-related cognitive impairment or are at risk thereof, including, without limitation, subjects having or at risk for Mild Cognitive Impairment (MCI), Age-related Cognitive Decline (ARCD) or Age-Associated Memory Impairment (AAMI). | 02-23-2012 |
| 20120046185 | PANEL OF BIOMARKERS FOR OVARIAN CANCER - The present invention provides a panel of protein-based biomarkers that are useful in diagnosing ovarian cancer in a subject. In particular, the panel of biomarkers of the invention are useful to classify a subject sample as having ovarian cancer or non-ovarian cancer. | 02-23-2012 |
| 20120040377 | RECOGNITION OF CYP2E1 EPITOPES - A critical epitope of human cytochrome P4502E1 (CYP2E1) associated with the development of hepatic autoimmune disease, including methods and kits for diagnosis and prognosis using the critical epitope as a biomarker for hepatic autoimmune disease. | 02-16-2012 |
| 20120039939 | COMPOSITIONS AND METHODS FOR VACCINE AND VIRUS PRODUCTION - The present invention features methods of producing immunogenic compositions and viruses, methods of treating and preventing viral infection, and methods of producing an immune response using cells that express a polypeptide selected from the group consisting of: cdk13, siat7e, Iama4, cox15, egr1, gas6, map3k9, and gap43, and a virus. | 02-16-2012 |
| 20120039839 | Hypoxia Induced Mitogenic Factor - We found that FIZZ1/RELMα is inducible by hypoxia in lung. The hypoxia-upregulated expression of FIZZ1/RELMα was located in the pulmonary vasculature, bronchial epithelial cells, and type II pneumocytes. Recombinant FIZZ1/RELMα protein stimulates rat pulmonary microvascular smooth muscle cell (RPSM) proliferation dose-dependently. Therefore, we renamed this gene as hypoxia-induced mitogenic factor (HIMF). HIMF strongly activated Akt phosphorylation. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 inhibits HIMF-activated Akt phosphorylation. It also inhibits HIMF-stimulated RPSM proliferation. Thus, the PI3K/Akt pathway, at least in part, mediates the proliferative effect of HIMF. HIMF also has angiogenic and vasoconstrictive activity. Notably, HIMF increases pulmonary arterial pressure and vascular resistance more potently than either endothelin-1 or angiotensin II. | 02-16-2012 |
| 20120035414 | CONTOURED ELASTOMERIC BARRIER FOR BOWEL RETENTION AND METHOD OF USE - The invention provides a device for bowel packing having an essentially elliptical shape that is essentially symmetrical along a minor axis of the ellipse, and the device includes a notch located on the minor axis below the major axis. The device is composed of material comprising an elastomeric polymer and the device is appropriately sized for retaining the intestines of a mammal. The invention further provides methods of use of the devices of the invention for bowel packing. The invention further provides methods for increasing bowel packing speed, increasing effectiveness of bowel retention, decreasing the formation of post-operative intraperitoneal adhesions, and increasing temperature of the abdominal cavity during surgery by use of the device. | 02-09-2012 |
| 20120034318 | DIAGNOSTIC METHOD USING PALB2 - The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient. | 02-09-2012 |
| 20120029071 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING RADIATION INJURY - The invention provides compositions and methods featuring Nrf2 activators for treating or preventing radiation-associated tissue damage. | 02-02-2012 |
| 20120029005 | SPIPERONE DERIVATIVES AND METHODS OF TREATING DISORDERS - Described herein are spiperone derivative compounds which have been found to be useful in methods of stimulating CaCC and treating disorders (or symptoms thereof) associated with CaCC including cystic fibrosis, wherein a compound of the invention is administered to a subject. | 02-02-2012 |
| 20120028921 | METHODS AND COMPOSITIONS USING OXIDIZED PHOSPHOLIPIDS - The instant invention provides compositions, e.g., compositions comprising oxidized phospholipids, for the treatment of diseases, disorders and conditions, e.g., cute lung injury syndromes, sepsis, vascular leakage, edema, acute respiratory distress syndrome (ARDS) or acute inflammation. | 02-02-2012 |
| 20120027799 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING INFLAMMATORY BOWEL DISEASE AND COLON CANCER - The invention provides compositions and methods for useful for the diagnosis of inflammatory bowel disease, ETBF-induced colitis, colonic hyperplasia and/or colon carcinogenesis in a subject in biological samples (e.g., stool, urine, blood, serum, tissue). The invention further provides compositions and methods for the treatment or prevention of colitis, colon cancer, or inflammatory bowel disease (e.g., Crohn's disease). | 02-02-2012 |
| 20120022232 | CELLS FOR INCREASED PROTEIN EXPRESSION COMPRISING ONE OR MORE RELEASE FACTORS AND METHODS OF USE - The invention provides recombinant cells or recombinant restrictive cells for overexpressing one or more proteins comprising one or more release factors. The invention also provides methods for producing a recombinant protein comprising culturing the cells of the present invention under conditions such that one or more proteins are overexpressed, and then isolating the expressed recombinant protein, In certain embodiments of the present invention, the gene encoding the protein is codon optimized. | 01-26-2012 |
| 20120010102 | MODULATION OF ABCG2-MEDIATED URATE TRANSPORT TO TREAT HYPERURICEMIA AND GOUT - Genome-wide association studies (GWAS) was recently used to identify SNPs in a genomic region on chromosome 4 that associate with serum urate levels and gout. The present disclosure shows that human ATP-binding cassette, subfamily G, 2 (ABCG2), encoded by the ABCG2 gene contained in this region, is a hitherto unknown urate efflux transporter. The present disclosure further shows that native ABCG2 is located in the brush border membrane of kidney proximal tubule cells, where it mediates renal urate secretion. Introduction of the mutation Q141K encoded by the common SNP rs2231142 by site-directed mutagenesis resulted in reduced urate transport rates compared to wild-type ABCG2. Data from a population-based study of 14,783 individuals support rs2231142 as the causal variant in the region and show highly significant associations with urate levels and gout. | 01-12-2012 |
| 20120009573 | Antisense Transcriptomes of Cells - Transcription in mammalian cells can be assessed at a genome-wide level, but it has been difficult to reliably determine whether individual transcripts are derived from the Plus- or Minus-strands of chromosomes. This distinction can be critical for understanding the relationship between known transcripts (sense) and the complementary antisense transcripts that may regulate them. Here we describe a technique that can be used to (i) identify the DNA strand of origin for any particular RNA transcript and (ii) quantify the number of sense and antisense transcripts from expressed genes at a global level. We examined five different human cell types and in each case found evidence for antisense transcripts in 2900 to 6400 human genes. The distribution of antisense transcripts was distinct from that of sense transcripts, was non-random across the genome, and differed among cell types. Anti-sense transcripts thus appear to be a pervasive feature of human cells, suggesting that they are a fundamental component of gene regulation. | 01-12-2012 |
| 20120009174 | BIOMARKERS FOR MYOCARDIAL ISCHEMIA - This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention. | 01-12-2012 |
| 20120009121 | PSMA-TARGETING COMPOUNDS AND USES THEREOF - Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described. | 01-12-2012 |
| 20120004289 | ANNEXIN A11 AND ASSOCIATED GENES AS BIOMARKERS FOR CANCER - The instant invention provides methods and compositions for the diagnosis and treatment of cancer. The invention also provides method and compositions for determining if a subject is, or is at risk of becoming, chemoresistant. | 01-05-2012 |
| 20120004133 | METHOD FOR THE DIAGNOSIS OF AGE-ASSOCIATED VASCULAR DISORDERS - Methods for determining if a subject has or is susceptible to having an age-associated vascular disorder are disclosed. The method includes determining if the subject exhibits altered expression of a product of one or more of the genes listed in Table 1 relative to a control level of expression of the gene product. Altered expression of one or more of the genes listed in Table 1 indicates that the subject has or is susceptible to having an age-associated vascular disorder. In specific examples the gene product is a product of the MFG-E8 and an increase in expression indicates the subject has or is susceptible to having an age-associated vascular disorder. | 01-05-2012 |
| 20120003156 | METHODS FOR TREATING NEOPLASIA BY INHIBITING LACTATE DEHYDROGENASE AND/OR NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE - The invention provides compositions for the diagnosis or treatment of neoplasias, including lymphomas, leukemias, brain cancers (e. glioblastomas, medulloblastomas), breast cancer, colon cancer, and pancreatic cancer, and methods of use therefor. | 01-05-2012 |
| 20110319939 | COMPRESSION-DISTRACTION SPINAL FIXATION SYSTEM AND KIT - Compression-distraction spinal fixation systems, and methods of performing compression-distraction spinal fixation, are provided that include screw-rod constructs having a ratcheting mechanism. Bone screws of the screw-rod constructs can have a pawl that engages ratchet teeth on the rod of the screw-rod construct. The bone screw can be unidirectionally ratcheted along the length of the rod to apply compressive or distractive forces. Tools for manipulation of the screw-rod constructs are also provided, which tools include distal tips configured to engage the bone screws. | 12-29-2011 |
| 20110319499 | Methods for the Detection of Advanced Glycation Endproducts and Markers for Disease - The present invention provides compositions and methods for detecting carboxymethyl-lysine (CML) and circulating receptor for advanced glycation end (RAGE) products, and methods for correlating CML and RAGE levels with age-related disease, hi particular, serum CML and/or circulating receptor for advanced glycation end (RAGE) products can be used as a clinical biomarker in diagnostics to identify people who are at a higher risk of developing adverse ageing-related outcomes. | 12-29-2011 |
| 20110319477 | MUTATIONS OF THE PIK3CA GENE IN HUMAN CANCERS - Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the PI3K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the PI3K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target. | 12-29-2011 |
| 20110317810 | METHODS AND SYSTEMS FOR LOCATING OBJECTS EMBEDDED IN A BODY - A method of processing image data from an imaging system for locating a plurality N of objects embedded in a body includes receiving data for a first two-dimensional image of a region of interest of the body containing the plurality N of objects, the first two-dimensional image being obtained from a first imaging setting of the imaging system relative to the region of interest; receiving data for a second two-dimensional image of a region of interest of the body containing the plurality N of objects, the second two-dimensional image being obtained from a second imaging setting of the imaging system relative to the region of interest; and receiving data for a third two-dimensional image of a region of interest of the body containing the plurality N of objects, the third two-dimensional image being obtained from a third imaging setting of said imaging system relative to said region of interest. | 12-29-2011 |
| 20110315656 | FERROMAGNETIC NANORINGS, MEDIUMS EMBODYING SAME INCLUDING DEVICES AND METHODS RELATED THERETO - Featured is a magnetic ring structure including at least a vortex magnetic state such as symmetrically and asymmetrically shaped nanorings, having small diameters (e.g., on the order of 100 nm). In particular embodiments, the width and thickness of the asymmetrical nanorings varies as a function of the locations on the circumference so that maxima and minima thereof are located on opposite sides of the nanoring. Also featured are methods for fabricating such symmetrically and asymmetrically shaped nanorings. Also featured are methods for controlling the reversal process so as to thereby create vortex states in such asymmetric nanorings by controlling the field angle. | 12-29-2011 |
| 20110313233 | DOWN-REGULATION OF COLD SHOCK PROTEINS FOR CANCER TREATMENT - The present invention is in the field of treatment of diseased tissues, including cancerous tissues. In one embodiment, the present invention provides methods of identifying tissues that down-regulate cold shock proteins in response to environmental stresses, such as heat. The present invention also provides methods of treatment of diseased tissues comprising down-regulation of cold shock proteins, as well as environmentally stressing (e.g., heating) the tissues, in combination with one or more additional therapies. | 12-22-2011 |
| 20110311791 | SYSTEM AND METHOD FOR PRECISION TRANSPORT, POSITIONING, AND ASSEMBLING OF LONGITUDINAL NANO-STRUCTURES - A method for assembling multi-component nano-structures that includes dispersing a plurality of nano-structures in a fluid medium, and applying an electric field having an alternating current (AC) component and a direct current (DC) component to the fluid medium containing the plurality of nano-structures. The electric field causes a first nano-structure from the plurality of nano-structures to move to a predetermined position and orientation relative to a second nano-structure of the plurality of nano-structures such that the first and second nano-structures assemble into a multi-component nano-structure. | 12-22-2011 |
| 20110311506 | PIGGYBAC TRANSPOSON VARIANTS AND METHODS OF USE - The present invention provides hyperactive piggyBac transposons, in particular hyperactive piggyBac transposons from | 12-22-2011 |
| 20110311500 | COMBINATION BACTERIOLYTIC THERAPY FOR THE TREATMENT OF TUMORS - Current approaches for treating cancer are limited, in part, by the inability of drugs to affect the poorly vascularized regions of tumors. We have found that spores of anaerobic bacteria in combination with agents which interact with microtubules can cause the destruction of both the vascular and avascular compartments of tumors. Two classes of microtubule inhibitors were found to exert markedly different effects. Some agents that inhibited microtubule synthesis, such as vinorelbine, caused rapid, massive hemorrhagic necrosis when used in combination with spores. In contrast, agents that stabilized microtubules, such as the taxane, docetaxel, resulted in slow tumor regressions that killed most neoplastic cells. Remaining cells in the poorly perfused regions of tumors could be eradicated by sporulated bacteria. Mechanistic studies showed that the microtubule destabilizers, but not the microtubule stabilizers, radically reduced blood flow to tumors, thereby enlarging the hypoxic niche in which spores could germinate. A single intravenous injection of spores plus selected microtubule-interacting agents was able to cause regressions of several tumors in the absence of excessive toxicity. | 12-22-2011 |
| 20110306614 | N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors - The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives. | 12-15-2011 |
| 20110305772 | COMPOSITIONS AND METHODS FOR EX VIVO HEPATIC NUCLEIC ACID DELIVERY - The invention provides compositions and methods for delivery of nucleic acids to the liver ex vivo. The method includes slow, low pressure infusion of the nucleic acid into the liver to efficiently transduce cells with minimal cell damage. | 12-15-2011 |
| 20110305768 | QUICK-DISSOLVING ORAL THIN FILM FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS - This invention describes a quick-dissolving thin film strips comprising bioactive components encapsulated within pH-sensitive polymeric microparticles. The microparticles are embedded within the thin film and provide protection to components encapsulated within. The invention further describes methods to incorporate bioactive components encapsulated within pH-sensitive polymeric microparticles into a quick-dissolving thin film strip while maintaining the bioactivity of the contained therapeutic agents during thin film formation and microencapsulation. | 12-15-2011 |
| 20110305689 | TREATMENT OF CHRONIC INFLAMMATORY RESPIRATORY DISORDERS - This invention relates, e.g., to a method for treating a subject having a chronic inflammatory respiratory disorder, comprising administering to the subject an effective amount of an inhibitor of the expression of and/or the activity of VEGF-A and/or VEGFR1 and/or VEGFR2 and/or NP1, or a combination thereof. Also described are screeing assays for agents for treating a subject having a chronic inflammatory respiratory disorder, and kits for performing one of the methods of the invention. | 12-15-2011 |
| 20110301646 | COMPRESSION-DISTRACTION SPINAL FIXATION SYSTEM - Compression-distraction spinal fixation systems, and methods of performing compression-distraction spinal fixation, are provided that include screw-rod constructs having a ratcheting mechanism. Bone screws of the screw-rod constructs can have a pawl that engages ratchet teeth on the rod of the screw-rod construct. The bone screw can be ratcheted along the length of the rod to apply distractive or compressive forces. | 12-08-2011 |
| 20110301226 | COMPOSITIONS AND METHODS FOR TREATING HEPATIC NEOPLASIA - The present invention provides compositions and methods featuring miR-26 microRNA polynucleotides for the diagnosis, treatment or prevention of hepatic neoplasia. | 12-08-2011 |
| 20110301163 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS - Described herein are methods of inhibiting methionine aminopeptidase or SirT1, inhibiting angiogenesis, and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, SirT1 and/or angiogenesis, wherein a compound of the invention is administered to a subject. | 12-08-2011 |
| 20110300168 | COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE AGAINST INFLUENZA ANTIGENS - This disclosure provides compositions and methods for inducing an immune response against influenza antigens, for example in elderly populations, as well as a sensitive artificial antigen presenting cell (aAPC) stimulation assay that can be used for expansion and analysis of multiple antigen specific T cell populations simultaneously. | 12-08-2011 |
| 20110287975 | Methods and Compositions for Correlating Genetic Markers with Conversion of Medium Chain Polyunsaturated Fatty Acids to Long Chain Polyunsaturated Fatty Acids - The present invention provides methods of identifying a subject having an increased or decreased ability to convert medium chain-polyunsaturated fatty acids (MC-PUFAs) to long chain polyunsaturated fatty acids (LC-PUFAs), comprising: (a) correlating the presence of one or more than one genetic marker in chromosome 11ql2-13, between build 37.1 position 61548559 and build 37.1 position 61560261, with an increased ability to convert MC-PUFAs to LC-PUFAs; and b) detecting the one or more than one genetic marker of step (a) in the subject, thereby identifying the subject as having an increased ability to convert MC-PUFAs to LC-PUFAs. Also provided are methods of correlating one or more genetic markers with an ability to convert MC-PUFAs to LC-PUFAs. | 11-24-2011 |
| 20110286931 | CARDIAC ARRHYTHMIA TREATMENT METHODS AND BIOLOGICAL PACEMAKER - Disclosed are methods of preventing or treating cardiac arrhythmia. In one embodiment, the methods include administering to an amount of at least one polynucleotide that modulates an electrical property of the heart. The methods have a wide variety of important uses including treating cardiac arrhythmia. Also disclosed are methods and systems for modulating electrical behavior of cardiac cells. Preferred methods include administering a polynucleotide or cell-based composition that can modulate cardiac contraction to desired levels, e.g., the administered composition functions as a biological pacemaker. | 11-24-2011 |
| 20110275565 | BIOCOMPATIBLE POLYSACCHARIDE-BASED HYDROGELS - Modified polysaccharides and crosslinked modified polysaccharide compositions are described. Methods of using the crosslinked modified polysaccharide compositions to deliver proteins, oligonucleotides, or pharmaceutical agents are also disclosed. | 11-10-2011 |
| 20110275103 | EMISSION RATIOMETRIC REPORTERS OF MEMBRANE PDK1 ACTIVATION - Phosphoinositide-dependent kinase 1 (PDK1) activity reporters can be used in high throughput assays for drug screening. | 11-10-2011 |
| 20110274330 | AUTOMATED CHARACTERIZATION OF TIME-DEPENDENT TISSUE CHANGE - A non-invasive medical imaging system includes: an imaging scanner capable of generating an imaging signal from a subject under observation inside the imaging scanner; a signal processing system in communication with the imaging scanner, and a data storage unit in communication with the signal processing system, wherein the data storage unit is suitable for storing a first image corresponding to a tissue region of the subject, wherein the signal processing system is capable of generating a second image encoding the tissue region of the subject by performing a reconstruction based on the imaging signal, the imaging signal acquired at a later time than the first image; wherein the signal processing system is constructed to receive the imaging signal from the imaging scanner and the first image from the data storage unit respectively, wherein the signal processing system is adapted to provide a registered first image by registering the first image to the second image via a transformation in a space of diffeomorphism, wherein the signal processing system is further adapted to compute a difference image between the second image and the registered first image; and wherein the signal processing system is further adapted to output the difference image. | 11-10-2011 |
| 20110270079 | COMPRESSION DEVICE FOR ENHANCING NORMAL/ABNORMAL TISSUE CONTRAST IN MRI INCLUDING DEVICES AND METHODS RELATED THERETO - Featured are devices for compression of target tissue while magnetic resonance imaging the target tissue and methods and systems related thereto. The method includes disposing target tissue between the fixed surface and the moveable member of a compression device and compressing the target tissue between the fixed surface and the moveable member. The method also includes acquiring one or more, more specifically a plurality, of sequences of image data of the compressed target tissue using an MRI imaging technique (MRI). In particular embodiments, the MRI technique is a SENC MRI technique, where tissue encoding is done prior to compressing the tissue and acquiring includes adding a gradient moment in the slice-selection direction to cause demodulation with a specific frequency. In further embodiments, the sequences of image data are acquired one of during successive periodic compressions of the tissue or successive periodic relaxation of the tissues. | 11-03-2011 |
| 20110269815 | METHODS OF REDUCING CELLULAR PROLIFERATION BY INHIBITING ACSVL3 - The present invention is directed to methods of reducing cancer cell proliferation and/or treating cancer by administering a therapeutically effective amount of a compound that inhibits the activity of ACSVL3. | 11-03-2011 |
| 20110269229 | METHODS OF INHIBITING VIRAL REPLICATION - The instant invention provides methods for the treatment and prevention of viral infection, e.g., HIV infection, based on the discovery that viral replication utilizes the ubiquitination pathway of the host cell to replicate. Specifically, the invention provides methods for the treatment and prevention of viral infection, e.g., HIV infection, by modulation of ISG15 conjugation and deconjugation, e.g., by modulation of the activity or expression of UBP43 or UBEL-1. | 11-03-2011 |
| 20110268741 | Immunotherapy for Contact Dermatitis Using Co-Signal Regulation - Compounds, compositions and methods for immunotherapy in contact dermatitis. Compounds and compositions (e.g. monoclonal antibodies) that stimulate the LAIR-1 expression pathway in LAIR-1 expressing immune cells and are useful for preventing or treating contact dermatitis are provided. | 11-03-2011 |
| 20110263668 | Beta 3-Adrenoreceptor Agonists for the Treatment of Cardiac Hypertrophy and Heart Failure - The present invention relates to the field of cardiology. More specifically, the present invention relates to the use of β3 adrenoreceptor agonists to treat cardiac hypertrophy and heart failure. In a specific embodiment, a method for treating cardiac hypertrophy comprises the step of administering a therapeutically effective amount of a β3 adrenoreceptor agonist to a patient diagnosed with cardiac hypertrophy. In a more specific embodiment, the method for treating cardiac hypertrophy comprises the step of administering a therapeutically effective amount of the β3 adrenoreceptor agonist BRL 26830A to a patient diagnosed with cardiac hypertrophy. In a further embodiment, the present invention provides a method for treating a cardiovascular disease or condition associated with cardiac hypertrophy comprising the step of administering a therapeutically effective amount of a β3 adrenoreceptor agonist to a patient diagnosed with cardiac hypertrophy. | 10-27-2011 |
| 20110262517 | CHIRALLY PURE ISOMERS OF ITRACONAZOLE AND INHIBITORS OF LANOSTEROL 14A-DEMETHYLASE FOR USE AS ANGIOGENESIS INHIBITORS - Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject. | 10-27-2011 |
| 20110262350 | BREAST ENDOTHELIAL CELL EXPRESSION PATTERNS - To gain a better understanding of breast tumor angiogenesis, breast endothelial cells (ECs) were isolated and evaluated for gene expression patterns. When transcripts from breast ECs derived from normal and malignant breast tissues were compared, genes that were specifically elevated in tumor-associated breast endothelium were revealed. These results confirm that neoplastic and normal endothelium in human breast are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future. | 10-27-2011 |
| 20110257146 | Method of Treating Kcnq Related Disorders Using Organozinc Compounds - The instant invention describes methods of treating KCNQ related diseases and disorders using organozinc compounds. In certain embodiments, pain is treated using Zinc Pyrithione. | 10-20-2011 |
| 20110256514 | METHODS AND SYSTEMS FOR PSYCHOPHYSICAL ASSESSMENT OF NUMBER-SENSE ACUITY - Featured are methods and systems for psychophysical assessment of number-sense acuity. Such methods include determining at least a display time based on participant related information (e.g., age) and selecting images for viewing by the participant based on the participant related information, the selected images having a complexity appropriate for the participant. Such methods further include displaying each selected image to the participant for the determined display time, the participant providing a reply to an assessment question after viewing each selected image, and determining a parameter representative of the psychophysical assessment of number-sense acuity based on each reply by the participant. | 10-20-2011 |
| 20110256212 | Use of 8-Quinolinol and its Analogs to Target Cancer Stem Cells - 8-quinolinol (8Q) and derivatives thereof for use in the treatment of proliferative diseases such as cancer, in particular slow metabolizing quiescent cancer stem cells. | 10-20-2011 |
| 20110256147 | DIAGNOSTIC AND TREATMENT METHODS FOR CANCER BASED ON IMMUNE INHIBITORS - Methods of diagnosis and treatment of malignant tumors, in particular ovarian tumors, using GD3 and GD3 inhibitors. Also provided are methods of modulating the immune system of a mammal by the administration of a GD3 and GD3 inhibitors. | 10-20-2011 |
| 20110256105 | CARDIAC STEM CELL AND MYOCYTE SECRETED PARACRINE FACTORS - The invention relates to secreted proteins from cardiac stem cells (cardiospheres and cardiosphere-derived cells) or myocytes for diagnostic and/or therapeutic use. | 10-20-2011 |
| 20110251504 | METHODS FOR DETERMINING RISK OF VENTRICULAR ARRHYTHMIA - Methods and systems are disclosed for analyzing three dimensional orthogonal ECG measurements to assess patient risk of a subsequent cardiac event based on evaluation of cardiac vector values in view of risk factors defined by the invention. | 10-13-2011 |
| 20110251100 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE AND RELATED DISORDERS - The present invention features biomarkers capable of diagnosing inflammatory bowel disease and methods of using such biomarkers to diagnose and selecting treatments for inflammatory bowel diseases. | 10-13-2011 |
| 20110250613 | Arrayed Multiple Ubiquitin Binding Domains as Linkage-specific Polyubiquitin Affinity Reagents - Linkage-specific polyubiquitin recognition is thought to make possible the diverse set of functional outcomes associated with ubiquitination. Thus far, mechanistic insight into this selectivity has been largely limited to single domains that preferentially bind to lysine 48-linked polyubiquitin (K48-polyUb) in isolation. A mechanism is proposed herein, linkage-specific avidity, in which multiple ubiquitin-binding domains are arranged in space so that simultaneous, high-affinity interactions are optimum with one polyUb linkage but unfavorable or impossible with other polyUb topologies and monoUb. The model used herein is human Rap80, which contains tandem ubiquitin interacting motifs (UIMs) that bind to K63-polyUb at DNA doublestrand breaks. The sequence between the Rap80 UIMs positions the domains for efficient avid binding across a single K63 linkage, thus defining selectivity. K48-specific avidity is also demonstrated in a different protein, ataxin-3. Using tandem UIMs, the general principles governing polyUb linkage selectivity and affinity in multivalent ubiquitin receptors are established. | 10-13-2011 |
| 20110250300 | COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATING TO OXIDATIVE STRESS - The present invention features methods for treating or preventing conditions, diseases, or disorders related to oxidative stress. In one embodiment, the method increases Nrf2 biological activity or expression. In particular, the invention provides for the treatment or prevention of diseases relating to oxidative stress including emphysema, sepsis, septic shock, ischemic injury, cerebral ischemia and neurodegenerative disorders, meningitis, encephalitis, hemorrhage, cerebral ischemia, heart ischemia, cognitive deficits and neurodegenerative disorders. | 10-13-2011 |
| 20110250129 | BIOLUMINESCENCE IMAGING-BASED SCREENING ASSAY AND INHIBITORS OF ABCG2 - A bioluminescence imaging-based high-throughput assay for inhibitors of ABCG2 is described. Compositions of inhibitors of ABCG2 and methods of using ABCG2 inhibitors are also described. | 10-13-2011 |
| 20110245691 | NON-INVASIVE METHODS AND SYSTEMS FOR ASSESSING CARDIAC FILING PRESSURE - Featured are methods and systems for assessing cardiac filing pressure non-invasively. Such methods include, inter alia, arranging a photoplethysmography (PPG) transducer on a finger of a patient and fluidly coupling a pressure transducer to the patient's mouth so that the pressure transducer measures expiratory pressure. The PPG transducer provides an output of a pulse volume signal of cardiac circulatory flow. Such methods also including determining a pulse amplitude ratio, using the pulse volume near the end of the expiratory effort and a baseline pulse volume, and assessing the pulse amplitude ratio so as to determine a filing pressure condition for the heart of the patient. | 10-06-2011 |
| 20110243967 | MOLECULAR COMPLEXES WHICH MODIFY IMMUNE RESPONSES - Extracellular domains of transmembrane heterodimeric proteins, particularly T cell receptor and major histocompatibility complex proteins, can be covalently linked to the heavy and light chains of immunoglobulin molecules to provide soluble multivalent molecular complexes with high affinity for their cognate ligands. The molecular complexes can be used, inter alia, to detect and regulate antigen-specific T cells and as therapeutic agents for treating disorders involving immune system regulation, such as allergies, autoimmune diseases, tumors, infections, and transplant rejection. | 10-06-2011 |
| 20110242306 | SYSTEM AND METHOD FOR AUTOMATED DETECTION OF AGE RELATED MACULAR DEGENERATION AND OTHER RETINAL ABNORMALITIES - A system and method for automated detection of age related macular degeneration and other retinal abnormalities which may have a retinal scanner capable of obtaining retinal data from a subject. The retinal scanner may be coupled to a central processing unit (CPU) which may have memory storing CPU-executable instructions which may detect retinal abnormalities. When the CPU receives retinal data from the retinal scanner, the system may perform CPU-executable instructions for detecting retinal abnormalities. The system may analyze the retinal data to determine one or more healthy areas and, based on the analyzed healthy area, the system may detect abnormalities in the retinal data. | 10-06-2011 |
| 20110237947 | ROBOTIC 5-DIMENSIONAL ULTRASOUND - A robotic 5D ultrasound system and method, for use in a computer integrated surgical system, wherein 3D ultrasonic image data is integrated over time with strain (i.e., elasticity) image data. By integrating the ultrasound image data and the strain image data, the present invention is capable of accurately identifying a target tissue in surrounding tissue; segmenting, monitoring and tracking the target tissue during the surgical procedure; and facilitating proper planning and execution of the surgical procedure, even where the surgical environment is noisy and the target tissue is isoechoic. | 09-29-2011 |
| 20110237945 | METHODS AND APPARATUS FOR ULTRASOUND STRAIN IMAGING - A system and method for improved ultrasound strain imaging includes using data from a tracking system to enhance the quality of ultrasound strain image and to reduce the dependency of image quality of the user's expertise. The tracking information is synchronized with the RF frames and interpolated to find the transformation corresponding to each frame. The RF frames with their transformations are incorporated into calculation of ultrasound strain images. The tracking system may be an optical tracker, electromagnetic tracker, accelerometer, or a structured light system. The structured light system may also be used for probe calibration, by calibrating the surface of the probe pre-operatively. In addition, a relative Young's Modulus may be calculated using tracking information that is independent from the distribution of input force. | 09-29-2011 |
| 20110231208 | SYSTEM AND METHOD FOR PATIENT SELF-ASSESSMENT OR TREATMENT COMPLIANCE - A system and method for transmission of alphanumeric messaging between mobile subscribers and an external system to send messages directly to the mobile subscriber's existing mobile phone to query them, for example, on the psychometric scale of interest. The resulting daily assessments may then be stored in a database that may be accessed via the interne to aid both the patient and a care provider in tracking the state and progress of the illness or symptoms which are being treated. It may allow the database to be queried to display trends over varying time intervals at any time in the past. The system and method may also provide for automatically notifying care providers if the patient is acutely having severe symptoms for a redefined duration and severity, and may facilitate a way to increase patient compliance with monitoring. | 09-22-2011 |
| 20110230942 | HIGH-RESOLUTION INFRARED IMAGING FOR ENHANCED DETECTION, DIAGNOSIS, AND TREATMENT OF CUTANEOUS LESIONS - A medical diagnosis system, comprising: a thermal stimulator; an infrared detection system constructed and arranged to detect infrared radiation from at least a portion of a subject under observation to provide an output signal from the portion of the subject after undergoing thermal stimulation from said thermal stimulator; and a signal processor in communication with the infrared detection system to receive the output signal from the infrared detection system, wherein the signal processor determines a measured thermal response of the portion of the subject to the thermal stimulation and compares the measured thermal response to an expected thermal response to determine a presence of an abnormality. | 09-22-2011 |
| 20110230451 | IDENTIFICATION AND USE OF COMPOUNDS THAT AFFECT THE FIDELITY OF EUKARYOTIC TRANSLATION INITIATION CODON SELECTION - A screening method for identifying compounds that alter the fidelity with which the initiation codon in mRNAs is recognized by the translational apparatus in eukaryotes is disclosed. This screening method was used to identify compounds having such activity. Methods of altering the fidelity of initiation codon selection are also disclosed. Methods of treating disorders characterized by single nucleotide mutations in initiation codons using compounds identified by the screening method, as well as methods of treating fungal and parasitic infections and hyperproliferative disorders using compounds identified by the screening method are also disclosed. | 09-22-2011 |
| 20110229498 | COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE - The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity. | 09-22-2011 |
| 20110229479 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 09-22-2011 |
| 20110225002 | SYSTEM AND METHOD FOR SHARING MEDICAL INFORMATION - A system and method for sharing information, comprising: creating at least one problem-oriented record utilizing at least one modifier to describe at least one attribute of at least one problem; and utilizing the at least one problem-oriented record to share information. | 09-15-2011 |
| 20110223146 | METHODS FOR PREPARATION AND USE OF MARROW INFILTRATNG LYMPHOCTYES (MILS) - The invention provides compositions comprising activated marrow infiltrating lymphocytes, methods of generating populations of marrow infiltrating lymphocytes, uses of the marrow infiltrating lymphocytes of the invention, and a culture device for use in cell culture, for example for use in generating populations of activated marrow infiltrating lymphocytes. In certain embodiments, the marrow infiltrating lymphocytes can be used as a cancer therapeutic. | 09-15-2011 |
| 20110217319 | METHODS OF USE OF SIALOADHESIN FACTOR-2 ANTIBODIES - Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents | 09-08-2011 |
| 20110212928 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION - The invention relates to methods and compositions for improving cognitive function by using a combination of a synaptic vesicle protein 2A (SV2A) inhibitor and an acetylcholinesterase inhibitor (AChEI) or their pharmaceutically acceptable salts, hydrates, solvates, polymorphs thereof. In particular, it relates to the use of a combination of an SV2A inhibitor and an AChEI in treating a central nervous system disorder with cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), dementia, Alzheimer's Disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, amyotrophic lateral sclerosis (ALS), and cancer-therapy-related cognitive impairment. | 09-01-2011 |
| 20110212052 | METHODS AND COMPOSITIONS OF TREATING AND PREVENTING AUTOIMMUNE DISEASES - Provided are methods and compositions for treating and/or preventing an autoimmune diseases, including inflammatory bowel disease, rheumatoid arthritis, diabetes mellitus, celiac disease, autoimmune thyroid disease, autoimmune liver disease, Addison's Disease, Sjögren's Syndrome, transplant rejection, graft vs. host disease, or host vs. graft disease. | 09-01-2011 |
| 20110212025 | TSPO-TARGETING COMPOUNDS AND USES THEREOF - Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described. | 09-01-2011 |
| 20110206734 | HYBRID SCFA-HYDROXYL-DERIVATIZED MONOSACCHARIDES, METHODS OF SYNTHESIS, AND METHODS OF TREATING DISORDERS - Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof. | 08-25-2011 |
| 20110201885 | ENVIRONMENT PROPERTY ESTIMATON AND GRAPHICAL DISPLAY - A surgical robot including an imaging system comprising at least one camera, a processor in communication with the imaging system, a manipulation system in communication with the processor, and a visual display in communication with the processor. The processor is operable to calculate a stiffness estimate for an area of an environment based on an environment model of tool-environment interaction data, create a composite image comprising a stiffness map of the stiffness estimate overlaid on an environment image from the at least one camera, and output the composite image on the visual display. | 08-18-2011 |
| 20110201675 | ON01910.Na ENHANCES CHEMOTHERAPEUTIC AGENT ACTIVITY IN DRUG-RESISTANT TUMORS - The invention includes compositions and methods of treatment of cancers susceptible to treatment with nucleotide analog chemotherapeutic agent, including cancers in which nucleotide analog resistant tumors have developed, including identifying a subject having cancer susceptible to treatment with a nucleotide analog chemotherapeutic agent and a mitotic disruptor/polo-like kinase (Plk) pathway inhibitor to a subject; and monitoring the subject for a reduction or stabilization of at least one sign or symptom of cancer. | 08-18-2011 |
| 20110201561 | TREATMENT OF METASTATIC COLON CANCER WITH B-SUBUNIT OF SHIGA TOXIN - The present invention relates to compositions and methods for treating invasive or metastatic cancer, particularly metastatic colon cancer using the B-submit of shiga toxin. The invention further provides methods of identifying compounds usefully for the treatment of invasive or metastatic cancer, particularly metastatic colon cancer. | 08-18-2011 |
| 20110201043 | TRANSGENIC MAMMALS AND CELL LINES FOR THE IDENTIFICATION OF GLUTAMATE TRANSPORTER MODULATORS - The invention includes a transgenic, non-human mammal useful for identifying candidate compounds for treating neurological and/or psychiatric disorders. Incorporated into the genome of the transgenic mammal is a transgene comprising a glutamate transporter promoter operatively linked to a reporter gene. The transgenic, non-human mammal and cells isolated therefrom can be used as an in vivo model for the identification of candidate compounds useful for the treatment of neurological and/or psychiatric disorders. | 08-18-2011 |
| 20110201004 | Digital Amplification - The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. Single molecules can be isolated by dilution and individually amplified; each product is then separately analyzed for the presence of pre-defined mutations. The process provides a reliable and quantitative measure of the proportion of variant sequences within a DNA sample. | 08-18-2011 |
| 20110200677 | PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) TARGETED NANOPARTICLES FOR THERAPY OF PROSTATE CANCER - The invention provides a nanoparticle composition that is decorated with a urea-based small-molecule peptidomimetic inhibitor of prostate specific membrane antigen (PSMA), which is expressed by almost all solid tumors. This strategy takes advantage of both the avidity of the functionalized nanoparticle for binding to PSMA and the ability of the nanoparticle to be retained for longer periods of time in the tumor due to enhanced leakage via EPR into the tumor interstitium and poor clearance due to underdeveloped or non-existent lymphatics within the tumor. | 08-18-2011 |
| 20110200578 | INTRAVENTRICULAR HEMORRHAGE THROMBOSIS - The invention provides methods of treating intraventricular hemorrhage using thrombolytic agents. | 08-18-2011 |
| 20110195416 | DISEASE DETECTION BY DIGITAL PROTEIN TRUNCATION ASSAYS - Genetic diseases can be diagnosed by detection of mutations in causative genes. Protein truncation assays can be used to detect gene products of truncation-type mutations. However, the sensitivity of the assays is often insufficient to detect mutations present in a sample of DNA at a low frequency. Sensitivity can be increased by dividing samples so that the signal generated by a mutant allele comprises a larger fraction of the total alleles than prior to dividing. Thus a previously undetectable signal generated by the mutant allele can become detectable in the assay. Such increased sensitivity permits detection at early stages and in samples having high levels of other alleles. | 08-11-2011 |
| 20110190845 | PORTABLE NEGATIVE PRESSURE VENTILATION DEVICE AND METHODS AND SOFTWARE RELATED THERETO - Featured is an apparatus an apparatus including a monitoring and sensing means, an electrode patch and a control device operably coupled to each of the sensing means and the electrodes and outputs signals to the electrodes for purposes of stimulating the phrenic nerve to thereby cause breathing by natural contraction of the diaphragm. The control device is configured and arranged to initially localize the phrenic nerve with respect to a given set of electrodes that is effective, when appropriately energized, for stimulating the phrenic nerve to establish negative pressure induced respiration in the body, based on the output signal(s) from the monitoring and sensing means. After such initially localizing; the control device thereafter repetitively outputs stimulation signals via the given set of electrodes so as to thereby continuously stimulate negative pressure induced respiration. Also featured are methods related thereto. | 08-04-2011 |
| 20110190199 | Combination Therapy for Tuberculosis - The present invention relates to methods of treating tuberculosis, including multi-drug resistant varieties and latent tuberculosis. More particularly, the present invention relates to a method of treating tuberculosis in a mammal comprising administering to said mammal in need thereof an effective amount of a compound of formula (I), (S)—N-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, or a pharmaceutically acceptable salt thereof in combination with at least two agents useful in the treatment of tuberculosis. The present invention also relates to a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, (ii) a therapeutically effective amount of at least one agent useful in the treatment of tuberculosis and (iii) one or more pharmaceutically acceptable carriers or vehicles. | 08-04-2011 |
| 20110189589 | COMPOSITE POROUS CATALYSTS - A composite catalyst for a chemical reaction includes a porous metal catalyst that catalyzes a plurality of reactants to provide a reaction product, and a reaction-enhancing material disposed within pores defined by the porous metal catalyst. The reaction-enhancing material enhances attraction of at least one reactant of the plurality of reactants into the pores defined by the porous metal catalyst and enhances expulsion of the reaction product from the pores defined by the porous metal catalyst. A fuel cell according to an embodiment of the current invention has a first electrode, a second electrode spaced apart from the first electrode, and an electrolyte arranged between the first and the second electrodes. The at least one of the first and second electrodes is at least one of coated with or comprises a composite catalyst. A method of producing a composite catalyst includes providing a metal alloy, de-alloying the metal alloy to provide a porous metal catalyst that catalyzes a plurality of reactants to provide a reaction product, and adding a reaction-enhancing material to the porous metal catalyst such that the reaction-enhancing material is disposed within pores defined by the porous metal catalyst. | 08-04-2011 |
| 20110184052 | ARGINASE II: A TARGET FOR THE PREVENTION AND TREATMENT OF ATHEROSCLEROSIS - The instant invention provides methods and compositions for the treatment of. atherosclerotic disease. Specifically, the invention provides methods and compositions for modulating the activity of Arginase II, the production of Arginase II or the amount of free Arginase II for the treatment of atherosclerotic disease. | 07-28-2011 |
| 20110183001 | COMPOSITIONS AND METHODS FOR IMPLANTATION OF ADIPOSE TISSUE AND ADIPOSE TISSUE PRODUCTS - The invention provides compositions and methods for the preparation of biocompatible biomaterials from adipose tissue. Biocompatible biomaterials are cellular or acellular biomaterials. The invention further provides methods of use of the biocompatible biomaterials. | 07-28-2011 |
| 20110178160 | Inhibition of Interaction of PSD93 and PSDS95 with nNOS and NMDA Receptors - PSD-95/SAP90 antisense-treated animals not only experience a significant decrease in MAC for isoflurane, but also experience an attenuation in the NMDA-induced increase in isoflurane MAC. PSD-95/SAP90 appears to mediate the role of the NMDA receptor in determining the MAC of inhalational anesthetics. Suppression of the expression of PSD-95/SAP90 in the spinal cord significantly attenuates responses to painful stimuli mediated through the N-methyl-D-aspartate receptor activation. In spinal cord neurons PSD-95/SAP90 interacts with the N-methyl-D-aspartate receptor subunits 2A/2B. Activation of the N-methyl-D-aspartate receptor in spinal hyperalgesia results in association of the N-methyl-D-aspartate receptor with PSD-95/SAP90. PSD-95/SAP90 is required for hyperalgesia triggered via the N-methyl-D-aspartate receptor at the spinal cord level. | 07-21-2011 |
| 20110177432 | POROUS METAL CATALYSTS FOR OXYGEN REDUCTION - A porous metal that comprises platinum and has a specific surface area that is greater than 5 m | 07-21-2011 |
| 20110177112 | MULTI- COMPONENT L2 VACCINE FOR PREVENTION OF HUMAN PAPILLOMA VIRUS INFECTION - Embodiments of the invention are directed to methods and compositions for generating an antibody response against HPV epitopes using multi-component vaccines. One such multi-component vaccine requires a T cell helper component and a toll-like receptor (TLR) agonist. In one embodiment, the inventors described a lipopeptide composition comprising an HPV L2 epitope. | 07-21-2011 |
| 20110177038 | Inhibition of Tumor Growth via Peroxiredoxin 3 - Deregulated expression of the c-Myc transcription factor is found in a wide variety of human tumors. Because of this significant role in oncogenesis, considerable effort has been devoted to elucidating the molecular program initiated by deregulated c-myc expression. The primary transforming activity of Myc is thought to arise through transcriptional regulation of numerous target genes. Thus far, Myc target genes involved in mitochondrial function have not been characterized in depth. Here, we describe a nuclear c-Myc target gene, PRDX3, which encodes a mitochondrial protein of the peroxiredoxin gene family. Expression of PRDX3 is induced by the mycER system and is reduced in c-myc−/− cells. Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence reveals that Myc binds preferentially to a 930-bp region surrounding exon 1. We show that PRDX3 is required for Myc-mediated proliferation, transformation, and apoptosis after glucose withdrawal. Results using mitochondria-specific fluorescent probes demonstrate that PRDX3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells. These data provide evidence that PRDX3 is a c-Myc target gene that is required to maintain normal mitochondrial function. | 07-21-2011 |
| 20110176998 | IMAGING AND THERAPY OF VIRUS-ASSOCIATED TUMORS - The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection. | 07-21-2011 |
| 20110172206 | COMPOSITIONS AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASE - Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed. | 07-14-2011 |
| 20110171741 | DNA INTEGRITY ASSAY (DIA) FOR CANCER DIAGNOSTICS, USING CONFOCAL FLUORESCENCE SPECTROSCOPY - The present invention relates, e.g., to a method for determining the size distribution of DNA molecules in a sample comprising cell-free nucleic acid, comprising labeling the DNA with a fluorescent dye in a stoichiometric manner, subjecting the DNA to molecular spectroscopy (e.g., cylindrical illumination confocal spectroscopy), analyzing suitable fluorescent burst parameters of the labeled DNA, and conducting single molecule DNA integrity analysis of the labeled DNA molecules in the sample. In one embodiment of the invention, the method is used as a diagnostic method for detecting cancer. | 07-14-2011 |
| 20110171266 | MALARIA VACCINE - The present invention features immunogenic compositions based on pre-fertilization or post-fertilization antigens expressed in the circulating gametocytes in the peripheral blood of infected persons or on the malaria parastes' stages of develop-ment in the mosquito midgut including extracellular male and female gametes, fertilized zygote and ookinete. The invention also features methods to prevent the transmission of malaria using the immunogenic compositions of the invention. | 07-14-2011 |
| 20110171230 | Method of Identifying Agents that Promote Axonal Development - The present invention is based on the discovery of a novel function of an FKBP proline isomerases in chemotropic nerve guidance and axon regeneration through gating of TRPC1 channel activity. Accordingly, there are provided methods for identifying an agent that inhibits FKBP52 binding to TRPC1. Also provided are methods for identifying an inhibitor of an FKBP52-TRPC1 signaling pathway by contacting a cell expressing TRPC1 and FKBP52 with a test agent and detecting a change in agonist-induced calcium flux of TRPC1. Further provided are methods of enhancing axonal outgrowth by inhibiting the activity of FKBP52 in a neuronal growth cone, and methods of enhancing axonal regeneration in a subject in need thereof by administering an agent that inhibits the activity of FKBP52. | 07-14-2011 |
| 20110171111 | BENT CARBON NANOTUBES AND METHODS OF PRODUCTION - A method of producing carbon nanotubes includes directing a flow of a gas over a substrate to provide growth of at least one carbon nanotube in a carbon-nanotube-growth region of the substrate; applying an electric field to the carbon-nanotube-growth region of the substrate after the at least one carbon nanotube has begun to grow in the carbon-nanotube-growth region, the electric field being substantially in a first direction in the carbon-nanotube-growth region; and changing the electric field at a preselected time to be substantially in a second direction in the carbon-nanotube-growth region during growth of the at least one carbon nanotube. The second direction is different from the first direction resulting in a bend substantially at a selected position of the at least one carbon nanotube, the method of producing carbon nanotubes providing the production of the at least one carbon nanotube having at least one bend substantially at a selected position along the at least one carbon nanotube. | 07-14-2011 |
| 20110167229 | BALANCED DATA-INTENSIVE COMPUTING - A computing device including a processor operable to process data at a processing speed and a storage device in communication with the processor operable to retrieve stored data at a data transfer rate, where the data transfer rate matches the processing speed. | 07-07-2011 |
| 20110165565 | COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE EXTRACTION AND METHYLATION DETECTION - The present invention features methods and compositions for methylation detection, as well as a novel method for polynucleotide extraction and sodium bisulfite treatment. | 07-07-2011 |
| 20110165223 | Antitumor Immunization by Liposomal Delivery of Vaccine to the Spleen - The present invention relates to methods for preventing, reducing or treating a variety of conditions, including cancer, and vaccines, compositions and liposomes used to elicit or amplify an immune response specific to the condition by delivering to the spleen of an individual a pegylated liposome construct having a diameter of greater than about 300 nm and including a therapeutic agent and an adjuvant for eliciting or amplifying the immune response. | 07-07-2011 |
| 20110163301 | PYROMELLITIC DIIMIDE ORGANIC SEMICONDUCTORS AND DEVICES - n-type organic semiconductors have a pyromellitic diimide structure and electronic or electro-optic devices include pyromellitic diimide compounds as organic semiconductors. Specific semiconductors include pyromellitic diimide compounds have sidechains comprising fluorine substituted aliphatic or aromatic moieties linked to the pyromellitic diimide structure by an alkylene or heteroalkylene linking group. An electronic or electro-optic device includes a first electrode, a second electrode space apart from the first electrode, and an organic semiconductor layer arranged between the first and second electrodes. The organic semiconductor layer comprises a pyromellitic diimide compound. | 07-07-2011 |
| 20110159504 | METHYLATION MARKERS FOR SENSITIVITY TO MICROTUBE BASED THERAPIES AND METHODS OF USE - The present invention relates to the use of nucleic acid methylation and methylation profiles to detect predict sensitivity of cells to cytotoxic chemotherapies, and in particular to microtubule based therapies, for example taxanes. The invention relates to methods for identifying a methylation profile of the checkpoint with forkhead and ring finger domains gene (CHFR) that is associated with a sensitivity to agents directed at the microtubule. | 06-30-2011 |
| 20110153547 | SYSTEM AND METHOD FOR SHAPE BASED RETRIEVAL OF PRIOR PATIENTS FOR AUTOMATION AND QUALITY CONTROL OF RADIATION THERAPY TREATMENT PLANS - A system and method for determining at least one new treatment plan for at least one new patient, comprising: providing at least one representation of the at least one new patient's at least one organ at risk relative to at least one target; searching for at least one prior treatment plan for at least one prior patient with at least one similar representation; and reviewing the at least one prior treatment plan for the at least one prior patient in order to determine whether the at least one new treatment plan can be improved based on information in the at least one prior treatment plan. | 06-23-2011 |
| 20110152711 | SYSTEMS AND METHODS FOR TESTING VESTIBULAR AND OCULOMOTOR FUNCTION - The invention relates to systems and methods for testing vestibular and oculomotor function. One aspect of the invention provides a vestibular and oculomotor function testing device including a track supported by a plurality of bearings, an engine configured to selectively displace the track, and a head coupling component coupled to the track. The head coupling component is configured to convey a movement generated by the engine to a subject's head in one or more axes. | 06-23-2011 |
| 20110150879 | SPECIFIC DEPLETION OF CD4+ T CELLS - Specific depletion or modulation of activity of CD4 | 06-23-2011 |
| 20110144474 | ADIABATIC MULTI-BAND RF PULSES FOR SELECTIVE SIGNAL SUPPRESSION IN MAGNETIC RESONANCE IMAGING - A magnetic resonance imaging (MRI) system, comprising: a magnetic resonance imaging scanner comprising: a main magnet providing a substantially uniform main magnetic field B0 for a subject under observation; and a radio frequency (RF) coil configured to irradiate a radio frequency (RF) pulse into a region of interest of the subject under observation, wherein the RF pulse comprises a base pulse comprising an adiabatic pulse having a first bandwidth time product (BWTP), wherein the RF pulse selectively suppresses magnetic resonance signals from more than one chemical component or more than one spatial region within the region of interest of the subject under observation, and wherein the adiabatic pulse is characterized by an amplitude modulation function and a frequency modulation function. | 06-16-2011 |
| 20110143379 | DETECTION AND QUANTITATION OF FULL-LENGTH THIOREDOXIN (TRX) AND TRUNCATED THIOREDOXIN (TRX 80) IN COMPLEX SAMPLES - The present invention relates, e.g., to a method for detecting a full-length protein and a truncated form (e.g., a naturally occurring cleavage product) thereof, in a sample, comprising
| 06-16-2011 |
| 20110142760 | PSMA-BINDING AGENTS AND USES THEREOF - Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis. | 06-16-2011 |
| 20110136692 | PROTEIN MICROARRAYS FOR MASS SPECTROMETRY AND METHODS OF USE THEREFOR - The present invention relates to the use of mass spectrometry to analyze arrays. The present invention provides methods for characterizing solutions comprising one or more proteins using arrays and mass spectrometry. The arrays of the present invention are coated with porous gold and utilize hydrophobic and hydrophilic self-assembled monolayers. | 06-09-2011 |
| 20110136145 | METHODS FOR PROMOTING FUSION AND REPROGRAMMING OF SOMATIC CELLS - The invention features methods for reprogramming somatic cells by treating the cells with one or more agents to induce de-differentiation, in particular by targeting demethylase and methyltransferase genes. The invention also features methods of monitoring somatic cell fusion and reprogramming and methods of identifying agents that alter somatic cell fusion and reprogramming. The invention also features reprogrammed cells and kits. | 06-09-2011 |
| 20110135620 | PRODRUG ACTIVATION IN CANCER CELLS USING MOLECULAR SWITCHES - The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a prodrug activating enzyme and a protein that binds a cancer specific marker, polynucleotides encoding the polypeptides, and molecular switches for converting a prodrug into a toxin, comprising the polypeptides. The invention also features methods for converting a prodrug into a toxin, methods for treating cancer, and methods for making the molecular switches, as well as kits. | 06-09-2011 |
| 20110129849 | DETECTION OF PROSTATE CANCER USING PSA GLYCOSYLATION PATTERNS - The present invention features novel methods for determining if a subject has prostate cancer. The present invention is based on the development of lectin immunosorbant assays which analyze α2,6-linked sialylation of total serum PSA by | 06-02-2011 |
| 20110125170 | HYDROGEL-GRAFTED DEGRADABLE NERVE GUIDES - The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve guides and methods for preparation of hydrogel-grafted nerve guides with encapsulated neurotrophic factors and a nanofiber mesh lining the inner surface of the guide. The present invention also provides methods for peripheral nerve repair using these hydrogel-grafted nerve guides. | 05-26-2011 |
| 20110125165 | SYSTEM AND METHOD FOR MACRO-MICRO DISTAL DEXTERITY ENHANCEMENT IN MICRO-SURGERY OF THE EYE - A system for operating within an interior region of the eye, or other organ, includes a delivery channel having a proximal portion located exterior to the eye and a distal portion positionable within the interior region of the eye, wherein the distal portion of the delivery channel defines an outer diameter that is smaller than or equal to about 18 gauge, and a micro-robot extendable from the distal portion of the delivery channel, wherein the micro-robot is remotely operable to change shape within the interior region of the eye. | 05-26-2011 |
| 20110124649 | INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS - Described herein are novel pyrimidine-pyridine compounds, methods of inhibiting methionine aminopeptidase and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, wherein a compound of the invention is administered to a subject. | 05-26-2011 |
| 20110123482 | Methods of Treating Neurological Autoimmune Disorders with Cyclophosphamide - Described herein are methods for treating neurological autoimmune disorders in which the treatment method includes administering an immunoablative agent to eliminate most or essentially all maturing and mature elements of the immune system in an affected individual. Following this step, the individual is administered agents to reestablish the ablated immune system. | 05-26-2011 |
| 20110117551 | DETECTION AND PROGNOSIS OF LUNG CANCER - Methods and tools are provided for detecting and predicting lung cancer. The methods and tools are based on epigenetic modification due to methylation of genes in lung cancer or pre-lung cancer. The tools can be assembled into kits or can be used seperately. Genes found to be epigentically silenced in association with lung cancer include ACSL6, ALS2CL, APC2, ART-S1, BEX1, BMP7, BNIP3, CBR3, CD248, CD44, CHD5, DLK1, DPYSL4, DSC2, EDNRB, EPB41L3, EPHB6, ERBB3, FBLN2, FBN2, FOXL2, GNAS, GSTP1, HS3ST2, HPN, IGFBP7, IRF7, JAM3, LOX, LY6D, LY6K, MACF1, MCAM, NCBP1, NEFH, NID2, PCDHB15, PCDHGA12, PFKP, PGRMC1, PHACTR3, PHKA2, POMC, PRKCA, PSEN1, RASSF1A, RASSF2, RBP1, RRAD, SFRP1, SGK, SOD3, SOX17, SULF2, TIMP3, TJP2, TRPV2, UCHL1, WDR69, ZFP42, ZNF442, and ZNF655. | 05-19-2011 |
| 20110110970 | CHIMERIC VACCINES - The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen sequence and a domain for trafficking the protein to an endosomal compartment, irrespective of whether the antigen is derived from a membrane or non-membrane protein. In one preferred aspect, the trafficking domain comprises a lumenal domain of a LAMP polypeptide. Alternatively, or additionally, the chimeric protein comprises a trafficking domain of an endocytic receptor (e.g., such as DEC-205 or gp200-MR6). The vaccines (DNA, RNA or protein) can be used to modulate or enhance an immune response against any kind of antigen. In one preferred aspect, the invention provides a method for treating a patient with cancer by providing a chimeric protein comprising a cancer-specific antigen or a nucleic acid encoding the protein to the patient. | 05-12-2011 |
| 20110110488 | COMBINED MULTI-DETECTOR CT ANGIOGRAPHY AND CT MYOCARDIAL PERFUSION IMAGING FOR THE DIAGNOSIS OF CORONARY ARTERY DISEASE - A computed tomography system has a support stage constructed and arranged to support a subject while under observation, an x-ray illumination system arranged proximate the support stage to illuminate the subject with x-rays, an x-ray detection system arranged proximate the support stage to detect x-rays after they pass through the subject and to provide signals based on the detected x-rays, and a data processing system in communication with the x-ray detection system to receive the signals from the x-ray detection system. The computed tomography system has a dynamic mode of operation and a scanning mode of operation. The data processing system extracts information concerning a dynamic process of the subject based on signals from both the dynamic mode and the scanning mode of operation. | 05-12-2011 |
| 20110106102 | Surgical Instrument and Systems with Integrated Optical Sensor - A surgical instrument has a surgical tool that has a proximal end and a distal end, and an optical sensor that has at least a portion attached to the surgical tool. The surgical tool has a portion that is suitable to provide a reference portion of the surgical tool, and the optical sensor has an end fixed relative to the reference portion of the surgical tool such that the reference portion of the surgical tool can be detected along with tissue that is proximate or in contact with the distal end of the surgical tool while in use. | 05-05-2011 |
| 20110104177 | HISTONE DEACETYLASE INHIBITORS, COMBINATION THERAPIES AND METHODS OF USE - The invention relates to histone deacetylase (HDAC) inhibitors to treat proliferative diseases. The present invention provides novel class III histone deacetylase inhibitors, in particular SIRT1 inhibitors, to reverse the silencing of hypermethylated genes, in combination with one or more other agents, in proliferative diseases such as cancer. The present invention provides methods of activating genes that are silenced by methylation in a subject by administering a HDAC inhibitor in combination with one or more agents. | 05-05-2011 |
| 20110104059 | Membrane Associated Tumor Endothelium Markers - To gain a better understanding of tumor angiogenesis endothelial cells (ECs) were isolated and gene expression patterns were evaluated. When transcripts from ECs derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, over 170 genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed differentially expressed genes, including many that were specifically elevated in tumor-associated endothelium. Experiments with representative genes from this group demonstrated that most were similarly expressed in the endothelium of primary lung, breast, brain, and pancreatic cancers as well as in metastatic lesions of the liver. These results demonstrate that neoplastic and normal endothelium in humans are distinct at the molecular level. | 05-05-2011 |
| 20110104052 | METHODS OF SYNTHESIS AND USE OF CHEMOSPHERES - The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent. | 05-05-2011 |
| 20110098333 | METHODS FOR TREATING OR PREVENTING BRAIN INFECTIONS - The invention is directed to methods of treating organ specific infections in a host organism by administering compounds that target host receptors and/or host cellular signaling molecules to prevent a pathogen from infecting the organ. For example, the administration of a compound to prevent a pathogen from crossing the blood-brain barrier to prevent a brain infection. | 04-28-2011 |
| 20110092794 | AUTOMATED SURFACE-BASED ANATOMICAL ANALYSIS BASED ON ATLAS-BASED SEGMENTATION OF MEDICAL IMAGING - A non-invasive imaging system, including: a non-invasive imaging scanner; a signal processing unit in communication with the imaging scanner to receive an imaging signal from a subject under observation; and a data storage unit in communication with the signal processing unit, wherein the data storage unit stores template data corresponding to a tissue region of the subject, and wherein the signal processing unit is adapted to generate a surface map to encode a property of a subvolume of the tissue region using the template data. | 04-21-2011 |
| 20110092601 | LYSINE-SPECIFIC DEMETHYLASE INHIBITORS - Polyamine, polyamine/guanidino, and polyamine/biguanide compounds bearing allene, propargyl, cyclopropyl, and other reactive moieties are disclosed. The compounds are useful as irreversible inhibitors of the enzyme lysine-specific demethylase-1 and for the treatment of cancer. | 04-21-2011 |
| 20110092462 | USE OF HIGH-DOSE OXAZAPHOSPHORINE DRUGS FOR TREATING IMMUNE DISORDERS - This disclosure relates, at least in part, to methods of eliminating adverse immune reactions in a subject in need thereof including those associated with autoimmune diseases, allergic reactions and transplant rejection, including administration of a lymphocytotoxic non-myeloablative amount of a oxazaphosphorine drug to the subject. | 04-21-2011 |
| 20110091497 | Method For Identifying and Validating Dominant T Helper Cell Epitopes Using An HLA-DM-Assisted Class II Binding Assay - Rational design of immunotherapeutics relies on clear knowledge of the immunodominant epitopes of antigens. Current methods for identifying kinetically stable peptide-MHC complexes are in many cases inadequate for a number of reasons. Disclosed herein is a reductionistic system incorporating known participants of MHC class II antigen processing in solution to generate peptide pools from antigens, including those for which no immunodominant epitope has yet been identified, that are highly enriched for proteolytic fragments containing their immunodominant epitopes. HLA-DM-mediated editing contributes significantly to immunodominance and is exploited in discovering immunodominant epitopes from novel or previously uncharacterized antigens, particularly antigens associated with pathogens, tumors or autoimmune diseases. | 04-21-2011 |
| 20110091384 | Biomarker for identification of melanoma tumor cells - This invention relates to use of neuropilin-2 as a novel biomarker and therapeutic target for melanoma. The presence of neuropilin-2 can be used as a biomarker for diagnosing and detecting individuals suffering from or at risk for developing melanoma. Also described are methods of using neuropilin-2 to capture circulating melanoma cells. The present invention further relates to methods of treating an individual suffering from or at risk for developing melanoma with an agent that inhibits the activity of neuropilin-2. | 04-21-2011 |
| 20110091377 | BIOMARKERS FOR MELANOMA - The present invention relates to methods of determining melanoma status in a subject. The invention also relates to kits for determining melanoma status in a subject. The invention further relates to methods of identifying biomarkers and correlating biomarker expression to melanoma status or stage in a subject. | 04-21-2011 |
| 20110077662 | DEVICES AND METHODS FOR TREATMENT OF GASTROINTESTINAL DISORDERS - An implantation device for releasably holding implantable microstimulators can be used to guide one or more microstimulators to any site within the gastrointestinal tract for implantation. The device can further releasably hold one or more ligation clips for securing the one or more microstimulators in place within the implantation site(s) and/or for closing an incision in which a microstimulator is implanted. The device can be employed using open, laparoscopic, and endoscopic techniques. | 03-31-2011 |
| 20110064657 | LABELED INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA), BIOLOGICAL EVALUATION, AND USE AS IMAGING AGENTS - The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable target for imaging and therapy of cancer. Various 99mTc/Re-labeled compounds were prepared by attaching known Tc/Re chelating agents to an amino-functionalized PSMA inhibitor with or without a variable length linker moiety. Ex vivo biodistribution and in vivo imaging demonstrated the degree of specific binding to engineered PSMA+ PC3 PIP tumors. | 03-17-2011 |
| 20110055964 | Method for Generating Hypermutable Plants - Blockade of mismatch repair in a plant can lead to hypermutation and a new genotype and/or phenotype. One approach used to generate hypermutable plants is through the expression of dominant negative alleles of mismatch repair genes in transgenic plants or derived cells. By introducing these genes into cells and transgenic plants, new cell lines and plant varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. Moreover, methods to inhibit the expression and activity of endogenous plant MMR genes and their encoded products are also useful to generate hypermutable plants. | 03-03-2011 |
| 20110038792 | INDUCTION OF THYROID IODIDE-HANDLING GENE EXPRESSION IN HUMAN CANCERS - Dual suppression of the MAP kinase and PI3K/Akt pathways showed synergistic or greatly enhanced anti-melanoma cell effects, compared to suppression of a single pathway, including the inhibition of cell proliferation, transformation and invasion, induction of G | 02-17-2011 |
| 20110037468 | OPTIMIZED MRI STRIP ARRAY DETECTORS AND APPARATUS, SYSTEMS AND METHODS RELATED THERETO - Featured is a device for NMR or MRI signals from excited nuclei as well as related apparatus, systems and methods. The device includes a strip array antenna including one or more conductor and N reactive tuning components, where N is an integer≧1 at least one of the N reactive components is electrically coupled to each of the one or more conductors as well as to ground/virtual ground. The apparent electrical length of the conductors is tuned with the reactive tuning components so it is equal to be about nλ/4, where n is an integer≧1 and λ is the wavelength of the signal to be detected. The length of the strip also is such as to be substantially in the approximate range of 1.3 times the depth of interest. The strip conductors are also combined with loop coils to form quadrature detectors. | 02-17-2011 |
| 20110033867 | Use of biomarkers for detecting ovarian cancer - The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject. | 02-10-2011 |
| 20110033466 | HUMAN TRANSCRIPTOMES - Global gene expression patterns have been characterized in normal and cancerous human cells using serial analysis of gene expression (SAGE). Cancer cell-specific, cell-type specific, and ubiquitously expressed genes have been identified. This information can be used to provide combinations of cell type- and cancer-specific gene probes, as well as methods of using these probes to identify particular cell types, screen for useful drugs, reduce cancer-specific gene expression, standardize gene expression, and restore function to a diseased cell or tissue. | 02-10-2011 |
| 20110028395 | PEPTIDE MODULATORS OF ANGIOGENESIS AND USE THEREOF - The invention generally features compositions and methods that are useful for modulating blood vessel formation, as well as methods that provide for the systematic and efficient identification of angiogenesis modulators. As described in more detail below, a systematic computational methodology based on bioinformatics was used to identify novel peptide modulators of angiogenesis that have been characterized in vitro and/or in vivo. | 02-03-2011 |
| 20110027295 | Adenosine Receptor Agonists and Antagonists to Modulate T Cell Responses - Described are uses of A2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses. A2a receptor antagonists in particular are provided to enhance immune responses by reducing T-cell mediated tolerance to antigenic stimuli and agonists are provided to enhance effectiveness of immunosuppressive agents. The application provides methods of treatment and prevention based on the long term effects of the compounds on T cell responses. | 02-03-2011 |
| 20110020239 | METHODS FOR IN VIVO IMAGING OF CELLS - The instant invention provides methods for the in vivo imaging of cells using one or more imaging modalities. | 01-27-2011 |
| 20110020232 | CANCER TREATMENT WITH GAMA-SECRETASE INHIBITORS - Provided are methods for treating cancer in a patient, comprising administering to a patient in need thereof a therapeutically effective regimen, the regimen comprising administering a gamma-secretase inhibitor, wherein the regimen results in a reduction in the cancer cell population in the patient. In some embodiments of the methods, the therapeutically effective regimen stabilizes, reduces or eliminates the cancer stem cell population. | 01-27-2011 |
| 20110020221 | CANCER STEM CELL EXPRESSION PATTERNS AND COMPOUNDS TO TARGET CANCER STEM CELLS - Described herein are therapeutic targets expressed in cancer stem cells and methods for treating and diagnosing cancer by targeting such cells with antibodies, compounds, nucleic acid, or other therapeutic agent. In one embodiment described herein, therapeutic agents for the treatment of cancer are provided based on the identification of cancer stem cell targets. The present invention also includes therapeutic targets for cancer therapy and cancer stem cell-targeted therapy. The invention includes the treatment of cancer by the administration of compounds or agents that target cancer stem cells. | 01-27-2011 |
| 20110016316 | AUTHENTICATED ADVERSARIAL ROUTING - A routing protocol is used to transmit messages from a sender to a receiver over a network of nodes, where adversaries can control links between the nodes and can also control the behavior of a large number of nodes. Various techniques can be used, along or in combination, to combat these effects. In one approach, certain trigger conditions are identified, the occurrence of which signals malicious behavior within the network. When signaled, the sender requests status reports from the intermediate nodes in an effort to determine which nodes are malicious. The information for the status reports is generated by nodes as packets are passed from one node to the next. | 01-20-2011 |
| 20110014192 | SUPPRESSION OF CANCER GROWTH AND METASTASIS USING NORDIHYDROGUAIARETIC ACID DERIVATIVES WITH METABOLIC MODULATORS - Disclosed is a composition comprising a derivative of NDGA and at least one metabolic modulator. The composition can be in a unit dose form or kit. The composition can comprise at least two metabolic modulators. Also disclosed are methods for achieving cytotoxicity, particularly of rapidly dividing cells such as cancer, by administering a composition of the invention. In various embodiments of the invention subjects with cancer achieve prolonged survival and/or diminution in the size of their malignancies and cancer metastasis. | 01-20-2011 |
| 20110014137 | METHODS FOR PROTECTING THE SKIN FROM RADIATION INSULTS - The present invention relates to methods and compositions for the protection of skin and mucous membranes from undesirable side effects of ionizing radiation in a patient undergoing ionizing radiation therapy. In particular, the application describes compositions and methods comprising the topical use of Nrf2 inducers. | 01-20-2011 |
| 20110009689 | ASSAY OF NITRIC OXIDE METABOLITES IN THE CULTURE MEDIA OF HUMAN PREIMPLANTATION EMBRYOS - The present invention relates, e.g., to a method for predicting the embryonic progression of a preimplantation embryo, comprising measuring in the insemination medium (IM) in which an oocyte was fertilized and subsequently incubated in vitro, thereby generating a pre-implantation embryo, at 18-24 hrs post fertilization, the levels of nitric oxide metabolites (NOx) in the insemination medium (IM), wherein a level of NOx of at least about 1.3 μM indicates that the preimplantation embryo is likely to progress to the blastocyst stage by culture day (CD) 5. | 01-13-2011 |
| 20110009469 | COMPOSITIONS AND METHODS OF TREATING NEOPLASIA - The present invention provides compositions and methods featuring microRNA polynucleotides for the diagnosis, treatment or prevention of neoplasia. | 01-13-2011 |
| 20110008349 | Hypoxia Induced Mitogenic Factor - We found that FIZZ1/RELMα is inducible by hypoxia in lung. The hypoxia-upregulated expression of FIZZ1/RELMα was located in the pulmonary vasculature, bronchial epithelial cells, and type II pneumocytes. Recombinant FIZZ1/RELMα protein stimulates rat pulmonary microvascular smooth muscle cell (RPSM) proliferation dose-dependently. Therefore, we renamed this gene as hypoxia-induced mitogenic factor (HIMF). HIMF strongly activated Akt phosphorylation. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 inhibits HIMF-activated Akt phosphorylation. It also inhibits HIMF-stimulated RPSM proliferation. Thus, the PI3K/Akt pathway, at least in part, mediates the proliferative effect of HIMF. HIMF also has angiogenic and vasoconstrictive activity. Notably, HIMF increases pulmonary arterial pressure and vascular resistance more potently than either endothelin-1 or angiotensin II. | 01-13-2011 |
| 20110003400 | METHODS AND SYSTEMS FOR GROUND AND SURFACE WATER SAMPLING AND ANALYSIS - The invention provides devices, methods, and kits for collection of dry samples from fluid samples such as ground or surface water. Devices of the invention include a casing including a water intake zone wherein the casing encloses, a fluid reservoir, a pump, a non-aqueous collection matrix cartridge, and a waste water conduit, wherein the water intake zone, the fluid reservoir, the pump, the non-aqueous collection matrix cartridge, and the waste water conduit are all operably linked in sequence. Methods for using the device of the invention are provided. Kits including the device of the invention or for use with the invention are also provided. | 01-06-2011 |
| 20110002997 | PHOTOINITIATED TISSUE FILLER - Visible light-activated polymer cosmetic filler preparations useful in a variety of applications are provided. In some embodiments, the photo-activated polymer composition comprises a conventional polymeric material, such as HA, together with a modified, cross-linkable polymer, such as PEG or PEODA, to permit the formation of crosslinks within the polymer matrix in situ on exposure to a visible light source, such as an IPL device. The preparations provide for a more stabilized composition that is contourable during gelation. | 01-06-2011 |
| 20110002944 | Compositions and Methods to Promote Neural Cell Growth - The instant invention provides methods and compositions for promoting neural cell growth by inhibiting myelin associated glycoprotein (MAG)-induced inhibition of axonal regeneration. The invention relates to methods for identifying agents that inhibit MAG-induced inhibition of neural cell growth. Methods for inhibiting myelin associated glycoprotein (MAG)-induced inhibition of neural cell growth in a patient, methods for treating or preventing a MAG-induced disease or disorder of the CNS or PNS, comprising the step of administering at least one of the compositions according to this invention are provided. The invention includes kits comprising one or more agents identified according to the invention. | 01-06-2011 |
| 20100331677 | MARKER DELIVERY SYSTEM - A marker delivery system including a surgical needle defining a lumen. The surgical needle is adapted to receive a marker. The surgical needle includes a side opening substantially adjacent to a first end of the surgical needle. The marker delivery system also includes a plunger insertable into the surgical needle at a second end of the surgical needle. Depression of the plunger inside the lumen of the surgical needle pushes the marker through the side opening of the surgical needle. | 12-30-2010 |
| 20100330156 | PHENAZINE DERIVATIVES AND USES THEREOF - The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. | 12-30-2010 |
| 20100330148 | MEHODS AND COMPOSITIONS FOR INHIBITING IMPDH-1 ISOFORM 1 - Described herein are methods of inhibiting IMPDH type 1, and treating or preventing a disease or disorder (or symptoms thereof) associated with IMPDH type 1, wherein an IMPDH type 1 inhibitor compound is administered to a subject. | 12-30-2010 |
| 20100320377 | LOW VOLTAGE, HIGH MASS RANGE ION TRAP SPECTROMETER AND ANALYZING METHODS USING SUCH A DEVICE - Featured is a quadrupole ion trap mass spectrometer having a compact configuration with a low voltage fundamental RF and using supplemental RF to a very low q | 12-23-2010 |
| 20100319073 | GDE Compositions and Methods - The present invention relates to compositions to treat glycerophosphodiester phosphodiesterase (GDE) related disorders. The invention also relates to methods treating GDE related disorders. The invention further relates to kits for treating GDE related disorders in a subject. The invention further relates to methods of identifying novel treatments for treating GDE related disorders in a subject. | 12-16-2010 |
| 20100313821 | BIOSAFETY LEVEL (BSL)-3 LIFE SUPPORT CELL FOR STUDYING LIVE ANIMALS - A biological safety system includes a life-support cell, a supply system fluidly connected to the life-support cell, and an exhaust system fluidly connected to the life-support cell. The life-support cell is structured to contain a laboratory animal infected with microorganism of a type that requires bio-safety level 3 (BSL-3) isolation, is transparent to at least one form of radiation to permit observation of the laboratory animal while in use, and the biological safety system contains the microorganism that infect the laboratory animal within the life-support cell while permitting the observations of the laboratory animal from a bio-safety level 2 (BSL-2) environment without the microorganism escaping from the life-support cell. | 12-16-2010 |
| 20100311073 | SR-BI AS A PREDICTOR OF ELEVATED HIGH DENSITY LIPOPROTEIN AND CARDIOVASCULAR DISEASE - The present invention relates to the field of single nucleotide polymorphisms (SNPs) and uses therefore as a predictor of diseases and conditions. Specifically, the present invention provides methods and kits useful in determining whether a subject is at increased risk for developing a cardiovascular disease by screening for the presence of a SNP in the scavenger receptor class B type I (SR-BI) gene of a subject. | 12-09-2010 |
| 20100305001 | FUNCTIONAL ASSAY FOR INDENTIFICATION OF LOSS-OF-FUNCTION MUTATIONS IN GENES - Provided herein are compositions and methods for assaying the deleteriousness of putative loss-of-function mutations, especially in genes known to be or suspected of being tumor-suppressor genes. The invention includes syngeneic variance libraries and methods of construction and use of syngeneic variance libraries. | 12-02-2010 |
