| The Jackson Laboratory Patent applications |
| Patent application number | Title | Published |
|---|
| 20120116414 | ANIMAL TAG APPLICATOR - Described are an animal tag applicator, a device for advancing a strip of animal tags, a leg bending die for bending the legs of animal tags, and methods for applying an animal tag to a body part of an animal. | 05-10-2012 |
| 20110307964 | MOUSE HAVING HUMAN LEUKEMIC STEM CELL AND LEUKEMIC NON-STEM CELL AMPLIFIED THEREIN, AND METHOD FOR PRODUCTION THEREOF - The invention relates to a method of selectively expanding human leukemic cells in a non-adult NOD/SCID/IL2rg | 12-15-2011 |
| 20110025831 | 3D Biplane Microscopy - A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data. | 02-03-2011 |
| 20100266530 | FcRN ANTIBODIES AND USES THEREOF - In certain embodiments, this present invention provides polypeptide compositions (e.g., antibodies and antigen binding portions thereof that bind to FcRn), and methods for modulating FcRn activity. In other embodiments, the present invention provides methods and compositions for treating autoimmune disorders. | 10-21-2010 |
| 20100265318 | 3D Biplane Microscopy - A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data. | 10-21-2010 |
| 20100209424 | ANTIBODIES AND FC FUSION PROTEIN MODIFICATIONS WITH ENHANCED PERSISTENCE OR PHARMACOKINETIC STABILITY IN VIVO AND METHODS OF USE THEREOF - In certain embodiments, this present invention provides antibodies and Fc fusion proteins with enhanced pharmacokinetics, such as biotinylated antibodies or biotinylated Fc fusion polypeptides. | 08-19-2010 |
| 20100168016 | DIAGNOSIS AND TREATMENT OF DISEASES CAUSED BY MISFOLDED PROTEINS - In certain aspects, the disclosure relates to methods and compositions for diagnosing and treating diseases caused by misfolded proteins that comprise monitoring ANKRD 16 expression and altering the activity of ANKRD 16 protein. In certain embodiments, the diseases are neurodegenerative diseases. In certain embodiments, the diseases are proteopathies. In certain embodiments, the disease is reduced fertility. Methods for identifying agents that protect against cell death are also provided. | 07-01-2010 |
| 20100113867 | METHODS FOR MAINTAINING GENETIC STABILITY OF INBRED ANIMAL STRAINS - The present invention provides novel methods of maintaining genetic stability of non-human animal inbred strains. In the methods, pedigree-tracked cryopreserved embryos or gametes or pre-gametes derived from a foundation colony are produced and used to re-establish the foundation colony at appropriate intervals. | 05-06-2010 |
| 20100095389 | METHODS OF MAINTAINING GENETIC STABILITY OF INBRED ANIMAL STRAINS - The present invention provides novel methods of maintaining genetic stability of non-human animal inbred strains. In the methods, pedigree-tracked cryopreserved embryos derived from a foundation colony are produced and used to re-establish the foundation colony at appropriate intervals. | 04-15-2010 |
| 20100074409 | METHOD AND APPARATUS FOR PREVENTING NEURODEGENERATION - A method for treating, preventing and/or reducing neurodegeneration in subjects with neurodegenerative disease, such as those neurodegenerative diseases that affect the eye, including glaucoma, using radiation, such as gamma radiation or X-ray radiation, either alone or together with a bone marrow transfer treatment. The method includes irradiating a targeted area of an animal, such as the eye region, with radiation, either alone or followed by injection with T-cell depleted bone marrow cells. Also a method for screening and/or selecting agents and/or treatment methods for inhibiting, treating and/or reducing neurodegeneration, particularly the neurodegeneration of the eye that occurs as a consequence of glaucoma. | 03-25-2010 |
| 20100058629 | LAB ANIMAL EAR TAG - An animal ear tag that is sufficiently light and small that it may be secured to the ear of an animal without causing irritation to the animal or loss of attachment. The ear tag includes an identification code that may be in the form of human-readable or machine-readable indicia or an RFID tag mounted on or inside the ear tag. The ear tag may be part of a sequential set of ear tags arranged in a strip. | 03-11-2010 |
| 20100023272 | Expression Data Analysis Systems and Methods - Methods and applications of Global Patter Recognition (GPR), including a system for analyzing the results of real-time polymerase chain reaction (RT-PCR) experiments employing micro-titer and/or microarray plates and robotic plate readers is described. The system employs a set of self-normalizing housekeeping primers or oligonucleotides on the plates/arrays and an algorithmic approach to normalizing expression data from all primers on the plate based on the reaction products of several of the self-normalizing gene primers oligonucleotides. Normalization is accomplished using simplex reactions involving these self-normalizing primers/oligonucleotides; the normalization parameters are then useable across all control and experimental reactions of the plate/array. A ranked list of genes whose amount of change is statistically significant can be determined. The accuracy of this list is enhanced by the data normalization aspect of the system. Other applications of GPR are also disclosed herein. | 01-28-2010 |
| 20090242798 | 3D Biplane Microscopy - A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data. | 10-01-2009 |
| 20090123439 | DIAGNOSTIC AND PROGNOSIS METHODS FOR CANCER STEM CELLS - The present invention provides methods for diagnosis and prognosis of cancer stem cells (CSC) using expression analysis of one or more groups of genes, and a combination of expression analysis from a biological sample from the subject. The methods of the invention provide a method for accuracy detecting cancer stem cells in a population of cancer cells. The invention also provides methods and kits for diagnosis and prognosis of cancer in a subject using cancer stem cell biomarker expression analysis. | 05-14-2009 |
| 20080269549 | METHOD, ARTICLE, AND APPARATUS FOR CRYOPRESERVATION OF BIOLOGICAL SAMPLES - Described herein is a method of storing a biological sample, such as a sperm sample, in an elongated container for cryopreservation. Multiple volumes of biological sample may be placed in each elongated container such that each volume of sample is separated from its nearest neighbor by a separation gas. The present invention further relates to an apparatus and method for loading biological samples, such as sperm samples, into an elongated container for cryopreservation of the sample material. The apparatus and method employs drawing the sample into the elongated container such that individual sample volumes are interspaced by gaps of separation gas. This alternating pattern may be created by repeatedly contacting and removing the elongated container from the sample under suction pressure. The apparatus further incorporates the use of a computer to control the volume and number of aliquots as desired. A container according to such methods is also provided. | 10-30-2008 |
