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The Govt. of USA. as represented by the Secretary of the Dept. of Health and Human Services

The Govt. of USA. as represented by the Secretary of the Dept. of Health and Human Services Patent applications
Patent application numberTitlePublished
20100260793DEFENSIN-ANTIGEN FUSION PROTEINS - The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.10-14-2010