| The Governors of the University of Alberta Patent applications |
| Patent application number | Title | Published |
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| 20120136185 | METHODS FOR PRODUCING FUELS AND SOLVENTS - Described herein are methods for producing fuels and solvents from fatty acid resources. Also disclosed herein are fuels and solvents produced by the methods described herein. | 05-31-2012 |
| 20120135392 | ULTRASOUND STIMULATION DEVICES AND TECHNIQUES - Ultrasound stimulation devices and related techniques are disclosed. An ultrasound transducer for generating ultrasound energy is carried by a transducer housing that seals the transducer and may also include a positioning element for positioning the transducer proximate an application area to which generated ultrasound energy is to be applied. The transducer housing may also carry such components as a battery, a wireless receiver, and a controller. The same housing or a separate sensor housing may include an ultrasound sensor that provides feedback to the ultrasound transducer or its controller, illustratively through a wireless transmitter. | 05-31-2012 |
| 20120115208 | MODULAR METHOD FOR RAPID ASSEMBLY OF DNA - The invention is directed to methods, kits and compositions using specially designed nucleic acid components for efficient assembly of a DNA construct. The method involves a) incubating a support with a first form of nucleic acid components under conditions to form support-bound nucleic acid component complexes; b) removing unbound first form nucleic acid components; c) incubating the support-bound first form nucleic acid component complexes with a second form of nucleic acid components under conditions to anneal and link the second form to the first form; d) removing unbound second form nucleic acid components; e) repeating steps c) and d) until the DNA construct is generated; and f) eluting the DNA construct from the support. The first and second forms of the nucleic acid component comprise sticky ends such that each form cannot link to itself but can link to each other to form an alternating head to tail sequence. | 05-10-2012 |
| 20120096924 | PARTICLE CLASSIFIER - A new installment classifies particles by their aerodynamic size This installment produces a truly monodisperse aerosol, and can produce very narrow distributions over a wide range of sizes Particles suspended in a fluid are classified by supplying particles into suspension in a carrier flow of a fluid and providing an acceleration to the flow at an angle to the velocity of the flow to cause the particles to follow trajectories determined by the acceleration and drag on the particles caused by the fluid The particles are then classified according to their trajectories The installment has a flow channel and a source of particles to supply particles into suspension in a carrier fluid in the flow channel A drive is connected to the flow channel at an angle to the flow of fluid through the carrier flow channel, and a classification system classifies the suspended particles according to their trajectories | 04-26-2012 |
| 20120083459 | USE OF GANGLIOSIDE TO DECREASE PROPAGATION OF MALIGNANT PROSTATE CELLS - Uses of exogenous ganglioside to inhibit the propagation of prostate cancer cells are provided. Gangliosides regulate many cellular processes including cell death. The present disclosure assesses the role of ganglioside in prostate cell growth. Malignant prostate (PC-3) and control (RWPE-1) cells can be cultured with or without ganglioside treatment. Cells can be assayed for differences in cell growth. Supplementation with ganglioside (GD3) can decrease growth of PC-3 cells by 30% compared to controls (p<0.01). Ganglioside can have therapeutic benefit in prostate cancer as demonstrated by decreased growth of malignant PC-3 cells. | 04-05-2012 |
| 20120060236 | AUXIN RECEPTORS - The invention is directed to isolated polynucleotide and polypeptides of the PsAFB2 and PsAFB6 genes from | 03-08-2012 |
| 20120059287 | ULTRASOUND STIMULATION DEVICES AND TECHNIQUES - Ultrasound stimulation devices and related techniques are disclosed. An ultrasound transducer for generating ultrasound energy is carried by a transducer housing that seals the transducer and may also include a positioning element for positioning the transducer proximate an application area to which generated ultrasound energy is to be applied. The transducer housing may also carry such components as a battery, a wireless receiver, and a controller. The same housing or a separate sensor housing may include an ultrasound sensor that provides feedback to the ultrasound transducer or its controller, illustratively through a wireless transmitter. | 03-08-2012 |
| 20120011624 | MICRO/NANO DEVICES FABRICATED FROM CU-HF THIN FILMS - An all-metal microdevice or nanodevice such as an atomic force microscope probe is manufactured from a copper-hafnium alloy thin film having an x-ray amorphous microstructure. | 01-12-2012 |
| 20120004219 | Method of Inhibition of Respiratory Depression Using Positive Allosteric AMPA Receptor Modulators - The invention is directed to a method for alleviating respiratory depression in a subject as a result of disease of pharmacological agents such as opiates, opioids or barbiturates. The invention also discloses pharmaceutical compositions for use with the method, the composition containing in combination, an analgesic, anaesthetic, or a sedative and a positive allosteric AMPA receptor modulator in an amount sufficient to reduce or inhibit respiratory depression caused by the analgesic, anaesthetic, or sedative. | 01-05-2012 |
| 20110312485 | METHOD FOR PREPARATION OF ACTIVATED CARBON - A method of preparing activated carbon, is disclosed, comprising: exposing carbonaceous material to microwave radiation in the presence of water to produce activated carbon. | 12-22-2011 |
| 20110278058 | NANOMATERIAL COMPOSITES AND METHODS OF MAKING - There is an electromagnetic interference shield and methods of constructing an electromagnetic interference shield. An electromagnetic interference shield has a network of conductive nanowires dispersed in a matrix material. The conductive nanowires form a segregated network. The segregated network may be a honeycomb network In a method for constructing an electromagnetic interference shield, a composite of conductive nanowires and matrix material is produced. Pockets of matrix material are formed within the composite of nanowires and matrix material. The pockets of matrix material may be formed by precipitation of the matrix material from a solvent or through dry-mixing of the composite with a second matrix material. | 11-17-2011 |
| 20110259076 | APPARATUS AND METHOD FOR ASSESSING PERCUTANEOUS IMPLANT INTEGRITY - Provided is an apparatus for assessing interface integrity between a medium and an implant. A first signal is translated from a motion of an impact body during impact with an abutment connected to the implant. In some embodiments, the first signal is filtered using a zero phase shift filter and then used for assessing the interface integrity. Since no phase shift is introduced, the interface integrity is accurately assessed. In another embodiment, the apparatus maintains a system model for impacting the impact body against the abutment. The apparatus analytically determines an interface property by applying a system property that has been determined to the system model. An accurate system model allows for an accurate assessment. According to another broad aspect, there is provided a method of conducting the impact test. According to the method, a person ensures that the impact body impacts against a consistent portion of the abutment. | 10-27-2011 |
| 20110243980 | METHODS AND SYSTEMS FOR O-GLYCOSYLATING PROTEINS - Described herein are methods and systems for O-glycosylating proteins in vivo or in vitro in any prokaryotic organism. In these methods and systems, DNA comprising a gene that produces a PglL-like oligosaccharyltransferase and DNA comprising a gene that produces a protein to be O-glycosylated are used. The PglL-like oligosaccharyltransferase facilitates the covalent attachment of the glycan to the protein to produce the O-glycosylated protein. The methods and systems described herein provide an approach for the design and production of new vaccines and therapeutic agents for the treatment of various diseases. | 10-06-2011 |
| 20110219478 | RECOMBINANT ANTIBODIES TO SCLEROTINIA ANTIGENS - The invention is directed to recombinant antibodies which bind to | 09-08-2011 |
| 20110212384 | ANODE CATALYSTS FOR FUEL CELL MEMBRANE REACTORS - Anode catalysts for conversion of hydrocarbon feeds in solid oxide fuel cell membrane reactors. An anode catalyst may be a mixture of a metal with a metal oxide, for example a mixture of copper or copper-nickel alloy or copper-cobalt alloy with Cr | 09-01-2011 |
| 20110206905 | METHOD FOR FORMING A BLOCK COPOLYMER PATTERN - A method for forming a block copolymer pattern on a substrate, wherein the areal density of nanostructures in the pattern is increased by increasing the thickness of the block copolymer film that is applied to the substrate. | 08-25-2011 |
| 20110195342 | SOLID OXIDE FUEL CELL REACTOR - An integral ceramic membrane for a fuel cell is provided, with a non-porous layer and porous layers both formed of proton conducting material. The proton-conducting material may be a compound or mixture of compounds of the formula X1-X2-O | 08-11-2011 |
| 20110174498 | HYDROCARBON RECOVERY PROCESS FOR FRACTURED RESERVOIRS - Steam-Over-Solvent Injection in Fractured Reservoirs (SOS-FR) is carried out by treating a fractured hydrocarbon bearing formation penetrated by a well with a first phase of injecting a formation compatible aqueous fluid into the fractured hydrocarbon bearing formation through the well, a second phase of injecting a hydrocarbon solvent into the fractured hydrocarbon bearing formation through the well and at least a third phase of repeating the first phase after the second phase. | 07-21-2011 |
| 20110128994 | ZONAL UWB RECEIVER AND METHOD - A novel ultra-wide bandwidth receiver structure dubbed the “zonal” receiver is proposed to detect time-hopping ultra-wide bandwidth signals in multiple access interference channels. The zonal receiver outperforms the conventional matched filter ultra-wide bandwidth receiver and the recently proposed soft-limiting ultra-wide bandwidth receiver when only MAI is present, or AWGN is negligible compared to MAI. In more practical mixed MAI-plus-AWGN environments, the zonal ultra-wide bandwidth receiver achieves better performance than the conventional matched filter ultra-wide bandwidth receiver, the recently proposed soft-limiting ultra-wide bandwidth receiver, and the recently proposed adaptive threshold soft-limiting ultra-wide bandwidth receiver. In multipath fading UWB channels, a new Rake receiver based on the zonal UWB receiver design has been proposed, this new Rake receiver can achieve better BER performance than the conventional matched filter based Rake receiver. | 06-02-2011 |
| 20110112604 | MITIGATION OF PRESSURE ULCERS USING ELECTRICAL STIMULATION - A method is provided for mitigating or preventing formation of pressure ulcers by transmitting an electrical stimulus sufficient to effect contraction of a loaded muscle, wherein the method comprises the steps of providing an electrical transmission for effecting contraction of the loaded muscle, transmitting sufficient electrical stimulation to the muscle to contract it for a predetermined period of time (the ON period), and ceasing transmission of the stimulus to the muscle for a predetermined period of muscle relaxation (the OFF period), whereby the predetermined period of relaxation is sufficient to cause sustained reoxygenation of the activated muscle. | 05-12-2011 |
| 20110071634 | End plate slider/distractor for posterior intervertebral device and method - A device and method for spreading apart adjacent vertebrae bodies for the safe insertion of an IBD into an IVD space said device designed for minimally invasive procedures and posterior or anterior approaches. | 03-24-2011 |
| 20110048945 | APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS - An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors. | 03-03-2011 |
| 20110041032 | Hybrid Message Decoders for LDPC Codes - Two hybrid message decoders for low-density parity-check (LDPC) codes are proposed. One decoder uses a posteriori probability ratio (APPR) and a posteriori probability difference (APPD), and the other decoder uses a logarithm a posteriori probability ratio (LAPPR) and a logarithm a posteriori probability difference (LAPPD) as hybrid message. Since the variable node and check node processing can be readily done using APPR and APPD, respectively, the proposed decoders have lower complexity than the conventional decoder that uses LAPPR only as a message. | 02-17-2011 |
| 20110035427 | PIXEL SENSOR CONVERTERS AND ASSOCIATED APPARATUS AND METHODS - There is described a pixel sensor converter for an image sensor array. In particular, a pixel sensor converter comprising: a delta-sigma converter comprising a modulator and a decimator. In some examples, the modulator is configured to be in communication with a detector, such as a photo-detector, and is configured to sample an analogue signal received from a detector at a particular sampling rate. The modulator is further configured to provide a bit stream of a particular bit rate. The provided bit stream corresponds to a sampled analogue signal. The decimator is in communication with the modulator, and is configured to receive and modify a bit stream provided from the modulator in order to provide a digital output signal. The provided digital output signal is representative of an analogue signal received at the modulator, but having a reduced bit rate than a corresponding bit stream provided by the modulator. | 02-10-2011 |
| 20110009492 | -PHENYLETHYLIDENEHYDRAZINE DERIVATIVES - The present invention provides new β-phenylethylidenehydrazine derivatives, processes for preparing them and their use as pharmaceutical compostions. The β-phenylethylidenehydrazine derivatives according to the invention generally correspond to the general formula: | 01-13-2011 |
| 20100326826 | APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS - An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors. | 12-30-2010 |
| 20100307238 | HUMIDITY SENSOR AND METHOD OF MANUFACTURING THE SAME - A humidity sensor comprising an insulating substrate, a moisture-sensitive layer, and at least a detection electrode contacting the moisture-sensitive layer, wherein the moisture-sensitive layer is a porous, photocatalytic metal oxide. | 12-09-2010 |
| 20100303916 | ENHANCED DRUG DELIVERY WITH ORIENTABLE PARTICLES - Small airway deposition of orientable drug particles in the lung due to interception is increased through alignment of these particles with an externally applied force such as a magnetic field. Drug particles in one embodiment are made magnetically responsive by loading them with magnetic nanoparticles. Elongated particles have a natural tendency to align parallel to the direction of flow through an airway, and therefore also parallel to airway walls; accordingly, alignment with a magnetic field to any other orientation increases interception, with a maximum increase for alignment perpendicular to airway walls. By positioning a magnetic field across a specific site within the lung, for example in the area of a tumor, the increase in deposition by interception allows localized targeting of inhaled drug particles to that area. | 12-02-2010 |
| 20100293674 | TRANSGENIC PLANTS EXPRESSING RECOMBINANT BARLEY ALANINE AMINOTRANSFERASE - Transgenic plants containing recombinant barley alanine aminotransferase are described. Also provided are methods for generating transgenic plants containing recombinant barley alanine aminotransferase. | 11-18-2010 |
| 20100269694 | Silicate Materials, Method For Their Manufacture, And Method For Using Such Silicate Materials For Adsorptive Fluid Separations - Embodiments of crystalline, titanium silicate molecular sieves are described having a formula representing mole ratios of oxides of n M | 10-28-2010 |
| 20100261889 | PROTEIN BASED FOAMING AGENTS AND METHODS OF MAKING THEREOF - Described herein are protein based foams and methods for making the same. The foams are derived from proteins that have been hydrolysed and chemically modified such that a foam produced from the protein has improved physical properties (e.g., reduced surface tension, increased foamability and foam stability). The protein is recovered from the animal rendering process as a component of an animal by-product (e.g., bloodmeal, bonemeal or meat). | 10-14-2010 |
| 20100240856 | Aromatic Ether-Containing Fluorene Monomers, Processes for their Preparation and Polymerization Thereof - Novel aromatic ether-containing monomers are described along with processes for their preparation and their polymerization into corresponding aromatic ether-containing polyfluorenes. These polyfluorenes exhibited stable blue-emission and therefore have application in polymer light-emitting devices. | 09-23-2010 |
| 20100207549 | LIGHT EMITTING SEMICONDUCTOR DIODE - Visible and infrared light sources on silicon that have several attractive properties with respect to integrated optics. First, the devices are operational at room temperature and strictly require no thermal processing in their synthesis (although low temperature annealing can be used to form Ohmic contacts). These devices could therefore be included at any stage of chip fabrication. The special ease of synthesis of these silicon LEDs enables simple fabrication of surface structures such as patterned emitters and photonic crystal surfaces that enhance light emission in the forward direction. The LEDs are color-switchable—by reversing the current one can switch from infrared emission to visible emission. The lifetime of the luminescence is much shorter than the standard carrier recombination time in silicon, suggesting direct modulation of the emitted light. | 08-19-2010 |
| 20100202734 | TAPERED WAVEGUIDE COUPLER AND SPECTROMETER - A method of forming a waveguide, the method comprising the steps of: forming a multilayer stack of light guiding layers; and delaminating the multilayer stack between at least two of the light guiding layers to form a waveguide between the light guiding layers; in which the patterned region has converging sides and the waveguide is tapered, the multilayer stack having increased transmissivity at a region corresponding to a selected thickness of the waveguide. A tapered waveguide is also disclosed, comprising: a multilayer stack of light guiding layers; the multilayer stack defining a channel between at least a first waveguiding layer and a second waveguiding layer; the channel having a diminishing thickness in a first direction; and at least one of the first waveguiding layer and the second waveguiding layer having a region of increased transmissivity adjacent a selected thickness of the core. Methods for the use of the tapered waveguide as an optical coupler or spectrometer are also disclosed. Methods for enhancing the optical resolution of the taper waveguide when operated as a spectrometer are also disclosed. | 08-12-2010 |
| 20100197960 | METHOD FOR THE ORGANOCATALYTIC ACTIVATION OF CARBOXYLIC ACIDS FOR CHEMICAL, REACTIONS USING ORTHOSUBSTITUTED ARYLBORONIC ACIDS - The present disclosure describes operationally simple methods for the low temperature, catalytic activation of carboxylic acids for organic reactions, in particular for direct amidation reactions with amines. The methods involve the use of orthosubstituted arylboromc acids of the formula (I), wherein the groups R | 08-05-2010 |
| 20100193737 | METHOD FOR PREPARING NANOCRYSTALLINE GERMANIUM IN GEO2 AND FREESTANDING GERMANIUM NANOPARTICLES - Methods for preparing nc-Ge/GeO | 08-05-2010 |
| 20100190460 | PRE-PROCESSOR FOR RECEIVER ANTENNA DIVERSITY - A dual-branch decorrelator receiver is provided in which decorrelation is performed with a simple addition and subtraction. The same receiver finds application in pre-processing signals that may not be correlated. | 07-29-2010 |
| 20100166695 | Multivalent Heterobifunctional Polymers And Methods Of Their Use - Designed herein are multivalent heterobifunctional polymers for binding to a biological target exhibiting biological activity and to an effector template which can affect the biological activity of the biological target or detect the presence of the biological target. The polymers comprise a plurality of pre-arranged heterobifunctional ligands connected thereto, and each heterobifunctional ligand comprises a first functionality capable of binding to the biological target, and a second functionality capable of binding to the effector template. The heterobifunctional ligands are pre-arranged on the polymer so as to form a ternary complex between the polymer, the biological target and the effector template. The polymers, methods and compositions described herein provide an approach for the design and production of new therapeutic agents as well as agents useful in a variety of non-therapeutic applications. | 07-01-2010 |
| 20100143820 | ANODE CATALYST AND METHODS OF MAKING AND USING THE SAME - The present disclosure relates to an ion conductive material useful as an anode catalyst comprising LaCrO | 06-10-2010 |
| 20100137206 | NOVEL LIGAND GUIDED BLOCK COPOLYMERS FOR TARGETED DRUG DELIVERY - This application relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on both the poly(ethylene oxide) block and the poly(ester) block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agent, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer. A variety of targeting moieties can be coupled to the reactive group on the poly(ethylene oxide) block for targeting the bioactive agent to a particular tissue. The application also relates to a composition and method of use thereof for delivering bioactive agents. | 06-03-2010 |
| 20100129383 | BIFUNCTIONAL FUSION MOLECULES FOR THE DELIVERY OF ANTIGENS TO PROFESSIONAL ANTIGEN-PRESENTING CELLS - The invention provides a bifunctional fusion molecule comprising: a first functional domain comprising a first immunoglobulin variable region, a second immunoglobulin variable region and a linker for connecting the first and second variable regions; a second functional domain comprising a moiety for binding to an antigenic agent; wherein the first and second functional domains are linked; and wherein the first functional domain specifically binds to a surface molecule of a professional antigen-presenting cell, and uses thereof. | 05-27-2010 |
| 20100113384 | BACTERIAL ENDOTOXIN FOR THE PREVENTION OF METABOLIC DISORDERS AND BACTERIAL INFECTIONS - The invention provides compositions and methods for preventing a metabolic disorder or bacterial infection in a subject, the composition comprising a bacterial endotoxin. | 05-06-2010 |
| 20100074307 | A P-ORDER METRIC UWB RECEIVER STRUCTURE WITH IMPROVED PERFORMANCE IN MULTIPLE ACCESS INTERFERENCE-PLUS-NOISE MULTIPATH CHANNELS - A UWB receiver dubbed the “p-order metric” receiver (p-omr) is proposed to detect the time-hopping ultra-wide bandwidth signal in multiple access interference channels. The receiver acquires a signal over a wireless channel, adaptively selects a shaping parameter, p, over time and generates a first set of partial statistics by, for each of a plurality N of observations per symbol, using the shaping parameter to modify the exponential order of the approximation of the noise plus multiple access interference probability density function, f(x), used in the receiver model. | 03-25-2010 |
| 20100069295 | NOVEL POLY(ETHYLENE OXIDE)-BLOCK-POLY(ESTER) BLOCK COPOLYMERS - The present invention relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on the polyester block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agents, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer. | 03-18-2010 |
| 20100061892 | MICROFLUIDIC DEVICE HAVING AN ARRAY OF SPOTS - A microfluidic spotting device has a first substrate patterned with an array of spots, a second substrate attached directly or indirectly to the first substrate, and channels formed at least partly in at least one of the first substrate and the second substrate, each channel having an inlet channel and an outlet channel. | 03-11-2010 |
| 20100021559 | ZEOLITE SUPPORTED METALLIC NANODOTS - A metal nanodot material is formed by ion-exchange with chabazite or a chabazite-like structure, followed by activation to form metallic nanodots. The nanodot may be formed from silver, nickel, copper, gold or a platinum group metal. | 01-28-2010 |
| 20100008401 | SYSTEM AND METHOD FOR RECEIVING TIME-HOPPING ULTRA-WIDE BANDWIDTHS SIGNALS - A novel receiver structure is proposed for detecting a time-hopping νltrat-wide bandwidth signal in the presence of multiple access interference. The proposed structure achieves better bit error rate performance than the conventional matched receiver when operating in multiple access interference. When operating in a multiple access interference-plus-Gaussian-noise environment, the receiver structure outperforms the conventional matched filter receiver for moderate to large values of signal-to-noise ratio. A receiver structure with adaptive limiting threshold is further proposed to ensure the performance of the soft-limiting receiver always meets or surpasses the performance of the conventional UWB receiver for all values of signal-to-noise ratio. | 01-14-2010 |
| 20090302208 | APPARATUS AND METHODS FOR LIQUID DROPLET DEPOSITION - A method of and an apparatus for generating droplets has a capillary tube mounted in a moveable member. The capillary tube is accelerated towards a plate, and then subject to rapid deceleration, e.g. by way of an impact, to promote separation of a droplet which is then deposited on the plate. The droplet can be entirely separated from the capillary tip before being deposited, or, for smaller droplets, the droplet merely extends from the capillary tip and is then drawn onto the plate by a wicking action. The plurality of capillary tubes can be mounted on the common support member to effect multiplexing of drops. | 12-10-2009 |
| 20090262869 | Decision-Feedback Detection for Block Differential Space-Time Modulation - Time variation on fading channels hinders accurate channel estimation in differential space-time modulation and deteriorates the performance. Decision-feedback differential detection is employed for block differential space-time modulation, and compared with conventional differential space-time modulation. It is observed that the proposed scheme does not suffer effective fading bandwidth expansion, as does the conventional scheme. An improved effective signal-to-noise ratio approach is proposed for analyzing the performance of the proposed scheme in time-varying flat Rayleigh fading. Theoretical analysis and simulations show the improved performance of the proposed scheme over the conventional scheme. | 10-22-2009 |
| 20090243635 | ANALYSIS OF THIN LIQUID FILMS - A novel microfluidic device has been developed to measure stability of thin liquid films of water in oil emulsions using electrochemical perturbation of interfaces. This new device can be utilized in rapid classification of de-emulsifiers used in petroleum industries. Although water/crude oil emulsions have been the primary focus of this research, this measurement platform can be used in other industries such as food, cosmetics and bio-engineering (bilayer lipid membranes) as well as environmental remediation of oil spills. The compact design of the device and replacement of the mechanical measurements such as pressure with electrical signal measurements contributes in substantial size reduction of the experimental platform so that it can be employed for onsite measurements in remote areas. | 10-01-2009 |
| 20090211632 | PHOTOVOLTAIC DEVICE BASED ON CONFORMAL COATING OF COLUMNAR STRUCTURES - A photovoltaic device, comprises a first electrode, an electron donor layer in electrical contact with the first electrode, an electron acceptor layer in contact with the electron donor layer across an interface having a shape defined by a columnar structure grown by oblique angle deposition, and a second electrode in electrical contact with the electron acceptor layer. | 08-27-2009 |
| 20090202655 | TITANOSILICATE MOLECULAR SIEVE SUPPORTED METALLIC NANODOTS AND METHODS OF USE TO ADSORB NOBLE GASES - A metal nanodot material is formed by ion-exchange with an ETS zeolite, followed by activation to form metallic nanodots. The nanodot may be formed from silver, nickel, copper, gold or a platinum group metal. | 08-13-2009 |
| 20090186859 | DIAZENIUMDIOLATED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, COMPOSITIONS THEREOF, AND RELATED METHODS - Disclosed are compounds that release nitric oxide, e.g., a compound of Formula (I) wherein R | 07-23-2009 |
| 20090170194 | TEAL FLUORESCENT PROTEINS - An isolated nucleic acid sequence encoding a non-oligomerizing Clavularia teal fluorescent protein (TFP) variant having a tyrosine-derived chromophore, and fragments and derivatives thereof. Also provided is a method for engineering the nucleic acid sequence, a vector comprising the nucleic acid sequence, a host cell comprising the vector, and use of the vector in a method for expressing the nucleic acid sequence. The present invention further provides an isolated nucleic acid, or mimetic or complement thereof, that hybridizes under stringent conditions to the nucleic acid sequence. Additionally, the present invention provides a non-oligomerizing TFP variant encoded by the nucleic acid sequence, as well as derivatives, fragments, and homologues thereof. Also provided is an antibody that specifically binds to the TFP variant. The present invention further provides a tandem dimer comprising two TFP dimers, operatively linked by a peptide linker. | 07-02-2009 |
| 20090103592 | MYRIAD FILTER DETECTOR FOR MULTIUSER COMMUNICATION - An adaptive receiver for multiple access communication, illustratively UWB multiple access communication, is provided. One embodiment of a detector is derived based on the finding that an symmetric alpha-stable model is more suitable for modeling the MAI in multiuser UWB systems than existing models. A myriad filter detector works better than all the known receiver structures proposed for statistical MAI cancellation. An intuitive expression for the tuning parameter K is provided which worked well in the examples considered. | 04-23-2009 |
| 20090092663 | Tumor-targeted drug delivery systems and uses thereof - The present invention relates to targeted delivery systems for delivering therapeutic agents to tumor. The invention further relates to methods of delivering a therapeutic agent to a tumor for the prevention and treatment of cancer by killing tumor cells and tumor-associated endothelial cells. In particular, the present invention provides a tumor-targeted drug delivery system comprising a NGR-containing molecule linked to a delivery vehicle encapsulating a therapeutic agent, preferably a drug, such as a cytotoxic agent or a chemotherapeutic agent. Specifically, the delivery systems of the present invention are capable of delivering an increased amount of therapeutic agent to a tumor as compared to other delivery systems. In particular, the delivery systems of the present invention are capable of accumulating a higher amount of therapeutic agent in a tumor, or in the vicinity of a tumor cell or tumor-supporting cell, resulting in exposure of the tumor cell and tumor-associated endothelial cell to therapeutic levels of the agent for a longer period of time as compared to other delivery systems. The present invention also describes pharmaceutical compositions comprising the delivery systems of the present invention. The present invention further relates to a tumor treatment comprising an increased amount of therapeutic agent delivered by the system of the present invention as compared to other delivery systems. The delivery systems and pharmaceutical compositions can be administered to a subject, preferably a human, alone or in combination, sequentially or simultaneously, with other prophylactic or therapeutic agents and/or anti-cancer treatments. | 04-09-2009 |
| 20090084679 | APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS - The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors. | 04-02-2009 |
| 20090042301 | TEMPERATURE REGULATED GENE EXPRESSION - A method for regulation of gene expression by variation of temperature uses a riboswitch. The riboswitch includes a 5′-UTR construct of crhC which alters its secondary structure in response to temperature, resulting in a more stable transcript at lower temperatures, permitting translation. At higher temperatures, the transcript is destabilized and functionally inactive. The 5′-UTR construct of crhC may be operatively linked to a promoter and a gene and administered to cells with an expression vector. | 02-12-2009 |
| 20090041733 | METHODS FOR CELL MOBILIZATION USING IN VIVO TREATMENT WITH HYALURONAN (HA) - The use of forms of hyaluronic acid having a molecular weight less than about 750,000 daltons selected from the group consisting of hyaluronic acid and pharmaceutically acceptable salts thereof is provided for the same purposes known for using recombinant GM-CSF or G-CSF. | 02-12-2009 |
| 20090029941 | METHODS FOR CELL MOBILIZATION USING IN VIVO TREATMENT WITH HYALURONAN (HA) - The use of forms of hyaluronic acid having a molecular weight less than about 750,000 daltons selected from the group consisting of hyaluronic acid and pharmaceutically acceptable salts thereof is provided for the same purposes known for using recombinant GM-CSF or G-CSF. | 01-29-2009 |
| 20080261962 | METHOD OF INHIBITION OF RESPIRATORY DEPRESSION USING POSITIVE ALLOSTERIC AMPA RECEPTOR MODULATORS - The invention is directed to a method for alleviating respiratory depression in a subject as a result of disease of pharmacological agents such as opiates, opioids or barbiturates. The invention also discloses pharmaceutical compositions for use with the method, the composition containing in combination, an analgesic, anaesthetic, or a sedative and a positive allosteric AMPA receptor modulator in an amount sufficient to reduce or inhibit respiratory depression caused by the analgesic, anaesthetic, or sedative. | 10-23-2008 |
| 20080259976 | Organic Columnar Thin Films - A thin film includes a substrate and a transparent, porous film of organic material, such as 8-hydroxyquinoline aluminum. The organic material is vapor deposited on the substrate such that the film has distinct helical columns extending away from the substrate. | 10-23-2008 |
| 20080242616 | PEPTIDE SPECIFICITY OF ANTI-MYELIN BASIS PROTEIN AND THE ADMINISTRATION OF MYELIN BASIC PROTEIN PEPTIDES TO MULTIPLE SCLEROSIS PATIENTS - Human myelin basic protein (h-MBP) has a molecular weight of 18.5 KD and contains 170 amino acid residues. Synthetic peptides ranging in length from about 8 to 25 residues and covering the entire length of the protein have been produced. Antibodies to h-MBP (anti-MBP) were found to be neutralized by the synthetic peptides, in vitro, which span the h-MBP from about amino acid residue 61 to about amino acid residue 106. The peptides, which cover both the amino (about residues 1 to 63) and carboxy (about residues 117 to 162) terminals of h-MBP did not neutralize purified anti-MBP. Intrathecal administration of peptide MBP(75-95), MBP(86-95), or MBP(82-98) produced complete binding-neutralization of free (F) anti-MBP with no change in bound (B) levels. A control peptide MBP35-58 had no effect on F or B anti-MBP levels. Intravenous administration of MBP(75-95), MBP(86-95), or MBP(82-98) resulted in significant decline of F and B CSF anti-MBP levels. Administration of MBP synthetic peptides to MS patients either intrathecally or intravenously did not have any adverse neurological effects and systemic complications did not occur. The MBP epitope for MS anti-MBP has been localized to an area between amino acid 86 and amino acid 95. | 10-02-2008 |
| 20080237146 | APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS - An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising: providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors. | 10-02-2008 |
