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The Government of United States of America, as represented by the Secretary of the Department
| The Government of United States of America, as represented by the Secretary of the Department Patent applications | ||
| Patent application number | Title | Published |
|---|---|---|
| 20110263974 | METHOD FOR PRESSURE MEDIATED SELECTIVE DELIVERY OF THERAPEUTIC SUBSTANCES AND CANNULA - Methods and devices are disclosed for selective delivery of therapeutic substances to specific histologic or microanatomic areas of organs. Introduction of the therapeutic substance into a hollow organ space (such as an hepatobiliary duct or the gallbladder lumen) at a controlled pressure, volume or rate allows the substance to reach a predetermined cellular layer (such as the ephithelium or sub-epithelial space). The volume or flow rate of the substance can be controlled so that the intralumenal pressure reaches a predetermined threshold level beyond which subsequent subepithelial delivery of the substance occurs. Alternatively, a lower pressure is selected that does not exceed the threshold level, so that delivery occurs substantially only to the epithelial layer. Such site specific delivery of therapeutic agents permits localized delivery of substances (for example to the interstitial tissue of an organ) in concentrations that may otherwise produce systemic toxicity. Occlusion of venous or lymphatic drainage from the organ can also help prevent systemic administration of therapeutic substances, and increase selective delivery to superficial epithelial cellular layers. Delivery of genetic vectors can also be better targeted to cells where gene expression is desired. The access device comprises a cannula with a wall piercing tracar within the lumen. Two axially spaced inflatable balloons engage the wall securing the cannula and sealing the puncture site. A catheter equipped with an occlusion balloon is guided through the cannula to the location where the therapeutic substance is to be delivered. | 10-27-2011 |
| 20100206096 | UNIVERSAL PHYSIOLOGIC SAMPLING PUMP (PSP) CAPABLE OF RAPID RESPONSE TO BREATHING - The present invention discloses a physiologic sampling pump (PSP) which uses at least one valve placed near the sampling medium to modulate air sampling to follow a person's inhalation rate and to obviate the sluggishness inherent in prior art PSPs caused by varying pump speed and by the propagation time through an air tube that connects the collection medium to prior art pumps thereby also obviating limitations inherent in system response, functionality, and accuracy. Moreover, by maintaining an essentially constant air flow through a cyclone at all times and through the collection medium while sampling, the present invention operates at known collection efficiencies, and is therefore capable of size-selective sampling of particulates as opposed to prior art PSPs that by varying the magnitude of air flow, make the separation efficiencies of pre-collection devices indeterminate and the samples worthless. When used instead with an impact sampling head, the present invention may collect total particulate as well, and may collect gases and vapors with a charcoal tube sampling head. Structural features associated with the physiological sampling pump for providing rapid response to breathing include an outer housing including a thereto-resistant case, multiple and interchangeable PSP sampling heads further including collection media and a valve(s) mounted on a valve manifold with associated tubing. | 08-19-2010 |