The Governing Council of the University of Toronto Patent applications |
Patent application number | Title | Published |
20160029619 | SYSTEM AND METHODS FOR AUTOMATED VITRIFICATION OF BIOLOGICAL MATERIALS - The present invention relaters to a system and methods for automated vitrification of mammalian oocytes or embryos. The system and methods enable automated processing of oocytes or embryos in vitrification solutions; robotically moving vitrification devices that carry processed cells for freezing in liquid nitrogen; automated sealing of the frozen devices; and transferring the sealed devices to an automated storage system for long-term cryopreservation. | 02-04-2016 |
20150333201 | PHOTOVOLTAIC DEVICES WITH PLASMONIC NANOPARTICLES - This application describes photovoltaic devices that include, in some embodiments, plasmonic nanoparticles and colloidal quantum dots and that have enhanced photovoltaic conversion efficiencies. This application also describes methods of making and using photovoltaic devices. Certain photovoltaic devices include plasmonic nanoparticles integrated with light absorbing semiconductor nanoparticles such as, but not limited to, colloidal quantum dots. Certain photovoltaic devices include solution-processed materials (e.g., colloidal plasmonic and light absorbing semiconductor nanoparticles) that are specifically tuned to enhance overall photovoltaic performance through increased absorbance of the light absorbing material. | 11-19-2015 |
20150177258 | SH2 DOMAIN VARIANTS - The present invention relates to variant SH2 domains for binding a phosphotyrosine (pTyr)-containing peptide. The variant SH2 domains of the present invention include a parent SH2 domain having at least one amino acid substitution in a pre-defined region of 15 amino acid positions of the parent SR2 domain, wherein said at least one amino acid substitution increases the affinity of the variant SH2 domain for the pTyr-containing peptide relative to the parent SH2 domain. The present application relates also to methods of using the variant SH2 domains in the treatment of protein kinase-associated disorders, or the diagnosis or prognosis of protein kinase-associated disorders, for isolating and measuring the concentration of pTyr-containing molecules, and as reagents in research. | 06-25-2015 |
20150107998 | PRINTED DIGITAL MICROFLUIDIC DEVICES METHODS OF USE AND MANUFACTURE THEREOF - Embodiments of the present disclosure digital microfluidic arrays that may be fabricated by a printing method, whereby digital microfluidic electrodes arrays are printed, via a printing method such as inkjet printing, onto a suitable substrate. In some embodiments, a substrate and/or ink is prepared or modified to support the printing of electrode arrays, such as via changes to the surface energy. In some embodiments, porous and/or fibrous substrates are prepared by the addition of a barrier layer, or, for example, by the addition or infiltration of a suitable material to render the surface capable of supporting printed electrodes. Various example embodiments involving hybrid devices formed by the printing of digital microfluidic arrays onto a substrate having a hydrophilic layer are disclosed. | 04-23-2015 |
20150086631 | Multi-Functional Micro and Nanoparticles for Use in Root Canal Therapies - Chitosan nanoparticles are provided for use in the in vivo treatment of connective tissues in root canal therapies. The nanoparticles are optionally linked with one or more photoactivatable compounds for providing antibactenal/antibiofilm properties, neutralizing bacterial byproducts and/or chemical/photodynamic crosslinking to achieve enhanced mechanical properties, chemical stability in connective tissues and/or to improve surface/interfacial integrity between filling material and connective tissue. | 03-26-2015 |
20140271673 | USE OF LXR ANTAGONISTS FOR TREATMENT OF SIDE EFFECTS OF ELEVATED GLUCOCORTICOID LEVELS - The present application is directed to uses of an agent that antagonizes the LXRβ receptor for the treatment of side effects associated with elevated glucocorticoid levels as well as uses of a glucocorticoid in combination with the agent that antagonizes the LXRβ receptor for treatment of a disease wherein glucocorticoid treatment is indicated. | 09-18-2014 |
20140243543 | IRON(II) CATALYSTS CONTAINING DIIMINO-DIPHOSPHINE TETRADENTATE LIGANDS AND THEIR SYNTHESIS - New hexa-coordinate iron (II) complexes comprising compounds of formula (I) are described. These compounds comprise a tetradentate ligand with donor atoms comprising nitrogen and phosphorus. These complexes are shown for the first time to be useful catalysts for the hydrogenation of ketones, aldehydes, or imines to produce alcohols or amines, and the asymmetric hydrogenation of prochiral ketones or imines to produce non-racemic alcohols or amines. The source of the hydrogen can be hydrogen gas or a hydrogen-donating molecule such as isopropanol or hydrogen-donating mixture such as formic acid and an amine depending on the structure of the catalyst. In certain embodiments, the axial ligands on the catalyst comprise organonitrile ligands, carbonyl ligands, isonitrile ligands, or combinations thereof. The catalysts and the preparation thereof are disclosed. A reaction using phosphine and diamine precursors that is templated by the iron ion is the preferred route to the catalysts. | 08-28-2014 |
20140213963 | IMPLANTABLE-GLUCOSE RESPONSIVE INSULIN DELIVERY DEVICE - A biocompatible insulin delivery device is provided comprising an insulin reservoir sealed with a glucose-responsive plug or membrane. The plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to hypoglycemic glucose concentration. In one embodiment, the plug is made of a biocompatible polymeric matrix comprising an inorganic component, a stimulus-responsive component and a catalytic component. | 07-31-2014 |
20140199719 | Impedance-Based Sensing of Adherent Cells on A Digital Microfluidic Device - Devices and methods are provided for measuring, on a digital microfluidic platform, electrical signals associated with the impedance of adherent cells. In one embodiment, a sub-droplet of cell culture media containing adherent cells is passively dispensed at a pre-selected electrode location where a local hydrophilic surface region is provided, and adherent cells are attached to the local hydrophilic surface region. The cell culture media sub-droplet is replaced with a sub-droplet of a low-conductivity medium in a passive dispensing step, retaining the attached adherent cells. An AC voltage with a suitable frequency is applied between electrodes of the device and a signal associated with the impedance of the adherent cells is obtained. One of the electrodes to which the AC voltage is applied may be a dedicated sensing electrode. The local thickness of a dielectric layer coating the pre-selected electrode may be reduced to increase the detection sensitivity of the device. | 07-17-2014 |
20140194468 | Compounds that Suppress Cancer Cells and Exhibit Antitumor Activity - The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitro and antitumor response in vivo. | 07-10-2014 |
20140193845 | USE OF SFRP-3 IN THE ASSESSMENT OF HEART FAILURE - Disclosed is a method for assessing heart failure in vitro including the steps of measuring in a sample the concentration of the marker SFRP-3, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for SFRP-3 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of SFRP-3 as a marker protein in the assessment of heart failure, a marker combination comprising SFRP-3 and a kit for measuring SFRP-3. | 07-10-2014 |
20140087375 | BIOPROBES AND METHODS OF USE THEREOF - Disclosed are biomolecule based bioprobes that exhibit improved water solubility and monolayer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bio-probe. Further disclosed are suitable electrochemical reporter systems for use with bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included. | 03-27-2014 |
20140085449 | SYSTEMS AND METHODS FOR THERMOPHOTONIC DYNAMIC IMAGING - Systems and methods for improved thermophotonic imaging are provided in which both amplitude and phase image information is obtained with a high signal to noise ratio and depth-resolved capabilities. Image data obtained from an imaging camera is dynamically averaged and subsequently processed to extract amplitude and/or phase image data. The system may be configured for a wide range of imaging modalities, including single frequency modulation (thermophotonic lock-in imaging), Thermal-Wave Radar imaging or Thermophotonic Radar imaging involving chirp modulation, and Binary Phase Coded Modulation. Such imaging modalities may find application in many diverse areas, including non-destructive testing and biomedical diagnostic imaging including the imaging of teeth and monitoring changes in the tooth over time which are due to pathology such as dental caries or erosion. | 03-27-2014 |
20140066496 | Composition and Methods for Anti-Macrofouling Treatment of Polymers - There is herein provided a composition comprising azadirachtin, preferably neem oil, and methods of use thereof for inhibiting macrofouling on a polymer in an aquatic environment. | 03-06-2014 |
20140057332 | GLUCO-OLIGOSACCHARIDE OXIDASES FROM ACREMONIUM STRICTUM AND USES THEREOF - This invention provides a description of novel polypeptides and nucleotide sequences having gluco-oligosaccharide oxidase (GOOX) activity. The polypeptides of the invention can be used for enzymatic processes that modify carbohydrates from wood fiber. These polypeptides can be used in the oxidation of C | 02-27-2014 |
20140005068 | PROTEIN DETECTION METHOD | 01-02-2014 |
20130302352 | Methods for the prevention and/or treatment of memory impairment - The present invention relates to methods for the prevention and/or treatment of memory impairment and for improving memory and particularly to methods for the prevention and/or treatment of memory impairment and improving memory comprising administering an agent that decreases activity of a GABA | 11-14-2013 |
20130277218 | DIGITAL MICROFLUIDIC DEVICES AND METHODS INCORPORATING A SOLID PHASE - Devices and methods are provided for performing droplet-based solid phase processing steps on a digital microfluidic device. A solid phase material, which may be a porous solid phase material such as a porous polymer monolith is formed or located on a digital microfluidic element. The solid phase may be formed by an in-situ method in which the digital microfluidic array is actuated to transport a droplet of solid phase pre-cursor solution to a selected element on the array, and subsequently processed to form a solid phase on the array element. The integration of a solid phase material with a digital microfluidic array enables a wide range of applications including solid phase extraction and sample concentration. | 10-24-2013 |
20130273561 | LIPID ENCAPSULATION OF SURFACE ENHANCED RAMAN SCATTERING (SERS) NANOPARTICLES - Phospholipid-microvesicle-encapsulated surface enhanced Raman scattering (SERS) nanoparticles and methods for making the encapsulated particles are described. The encapsulated particles can be used in nanomedicine. Four Raman-active species were used. A bilayer was observed by TEM, and the SERS spectrum of each dye species (SERS reporter) was confirmed. | 10-17-2013 |
20130244883 | Molecular Display Method - There is provided herein a method for identifying and/or recovering at least one genetically encoded affinity reagent specific for a target molecule by screening using molecular display in conjunction with the sequencing of positive and negative selection pools from the screen. | 09-19-2013 |
20130240456 | DEVICE AND METHOD FOR LABEL-FREE SEPARATION OF MATERIAL USING MAGNETIC FIELD - Devices and methods for label-free separation of material. A fluid-filled settling chamber is used for settling material by gravity. A fluid mixture comprising a target material and at least one non-target material is introduced into the settling chamber, where the target material has a paramagnetic property. A magnetic field is applied to the settling chamber sufficient to impede gravitational settling of the target material and not affect gravitational settling of the non-target material, in order to separate the target material from the non-target material. | 09-19-2013 |
20130225436 | SPECIFIC ACTIVE SITE INHIBITORS OF ENZYMES AND METHODS OF PRODUCING SAME - The present disclosure provides a method of producing enzyme-specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs. | 08-29-2013 |
20130183665 | SYNTHESIS OF FLUORESCENT NOBLE METAL NANOPARTICLES - A process for the production of fluorescent nanoparticles selected from noble metal, silica or polymer nanoparticles which comprises: 1. A process for the production of fluorescent nanoparticles selected from noble metal or silica nanoparticles which comprises: (1) providing a platform of nanoparticles; (2) covering the surfaces of the nanoparticles to saturation with thiol-terminated polymers by one of the following methods: 1. mixing the nanoparticles with methoxy-(polyethylene glycol)-thiol and biotin-(polyethylene glycol)-thiol; 2. mixing the nanoparticles with fluorescently-labeled methoxy-(polyethylene glycol)-thiol and/or biotin-(polyethylene glycol)-thiol 3. coordinating thiol and biotin thiol to the surfaces of the nanoparticles by a non-covalent bond; and 4. directly conjugating methoxy-thiol and biotin-thiol to the surfaces of the nanoparticles, so that the polymers bind to the surfaces of the nanoparticles as a brush layer via thiol particle coordination of the thiol ends so that the biotin or methoxy ends are free; and (3) homogeneously mixing the resulting biotin nanoparticles with fluorescent avidin or a derivative thereof in proportions such that the final concentration is 1 biotin molecule for every 10 to 1000 avidin molecules in the fluorescent multi-coloured nanoparticle-avidin complexes, each being capable of having a different targeting molecule, and which may be mixed with biotin related targets, and the fluorescent labeled avidin or a derivative thereof being spaced away from the particle surface, thus reducing or removing the potential quenching of the dye. | 07-18-2013 |
20130172266 | MITOCHONDRIAL PENETRATING PEPTIDES AS CARRIERS FOR ANTICANCER COMPOUNDS - There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an anti-cancer compound, and their method of use. | 07-04-2013 |
20130171186 | BROAD SPECTRUM INFLUENZA A NEUTRALIZING VACCINES AND D-PEPTIDIC COMPOUNDS, AND METHODS FOR MAKING AND USING THE SAME - GB1 peptidic compounds that specifically bind to a hemagglutinin target protein, and libraries that include the same, as well as methods of making and using the same, are provided. Also provided are methods and compositions for making and using the compounds. Also provided are hemagglutinin mimics and fragments and methods of using the same, including methods of screening for GB1 peptidic compounds and methods of using conjugates the mimics as influenza A vaccines. Aspects of the invention include methods of screening libraries of L-peptidic compounds for specific binding to a D-peptidic hemagglutinin target protein. Once a L-peptidic compound has been identified that specifically binds to the D-peptidic hemagglutinin target protein, the D-enantiomer of the selected L-peptidic compound may be produced. In some embodiments, the D-enantiomer of the selected L-peptidic compound binds to, and in some instances, neutralizes influenza virus particles. | 07-04-2013 |
20130157931 | MITOCHONDRIAL PENETRATING PEPTIDES AS CARRIERS FOR ANTIMICROBIALS - There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an antimicrobial, and their method of use. | 06-20-2013 |
20130143312 | DROPLET-BASED CELL CULTURE AND CELL ASSAYS USING DIGITAL MICROFLUIDICS - We introduce a new method for implementing cell-based assays and long-term cell culture. The method is based on digital microfluidics (DMF) which is used to actuate nanoliter droplets of reagents and cells on a planar array of electrodes. DMF method is suitable for assaying and culturing both cells in suspension and cells grown on surface (adherent cells). This method is advantageous for cell culture and assays due to the automated manipulation of multiple reagents in addition to reduced reagent use and analysis time. No adverse effects of actuation by DMF were observed in assays for cell viability, proliferation, and biochemistry. These results suggest that DMF has great potential as a simple yet versatile analytical tool for implementing cell-based assays and cell culture on the microscale. | 06-06-2013 |
20130122533 | METHOD OF PRODUCING ELECTRICALLY CONDUCTIVE POLYMER AND CELLULOSE NANOCOMPOSITES - A method is provided for preparing electrically conductive polymer and cellulose nanocomposite particles and nanocomposite materials. Cellulose microparticles coated with a conductive polymer are added to an acid solution for initiating an acid hydrolysis reaction for a prescribed time interval to form conductive polymer coated cellulose nanoparticles. After quenching the acid hydrolysis reaction, the nanoparticles are separated to obtain a colloidal solution of conductive nanoparticles. The conductive nanoparticles may be subsequently formed into a solid nanocomposite material such as a conductive film. Transparent conductive films may be prepared by forming thin layers having a thickness on a micron or submicron scale. | 05-16-2013 |
20130096006 | AQUEOUS BASED PROCESS TO FABRICATE NANOSTRUCTURED BLOCK COPOLYMER FILMS - The present invention provides a method to transfer block copolymers from water immiscible organic phase to aqueous phase using a phase transfer agent. At higher concentrations, micellar networks of the block copolymers were obtained in the aqueous solution that can be coated onto a variety of substrates. Block copolymer films showed very good antifouling properties. The phase transferred block copolymers can be used to synthesize encapsulated nanoparticle aggregates for biodiagnostic imaging applications. The phase transferred block copolymer micelles can be used to encapsulate active compounds. The invention has applications in drug delivery, crop protection, and medical device coating. | 04-18-2013 |
20130045416 | GOLD MICRO- AND NANOTUBES, THEIR SYNTHESIS AND USE - Synthesis of gold microtubes and nanotubes suspendable in solution is presented. The synthesis is accomplished using an AAO template route, wherein a polymer tube is used as a sacrificial core. The synthesis produces hollow structures that consist of only gold. These nanostructures exhibit two SPR modes, which correspond to both the transverse and longitudinal modes. The mode assignment was confirmed by measuring SPR behavior as both aligned arrays and in solution. The performance of gold nanotubes as refractive index detectors was quantified and determined to be more sensitive than analogous solid nanorods prepared under identical conditions, and are among the most sensitive nanostructured plasmon sensors to date. Due to their intense and sensitive resonances in the NIR spectrum, these solution-suspendable nanoparticles have potential to be used as in vitro or in vivo sensors. | 02-21-2013 |
20120295329 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY - This invention provides novel chemically modified mutant serine hydrolases that catalyze a transamidation and/or a transpeptidation and/or a transesterification reaction. The modified serine hydrolases have one or more amino acid residues in a subsite replaced with a cysteine, wherein the cysteine is modified by replacing the thiol hydrogen in the cysteine with a substituent group providing a thiol side chain comprising a moiety selected from the group consisting of a polar aromatic substituent, an alkyl amino group with a positive charge, and a glycoside. In particularly preferred embodiments, the substitutents include an oxazolidinone, a C | 11-22-2012 |
20120295289 | DEVICE AND METHOD FOR CULTURING CELLS - A device and method for culturing cells is described. Culture media is continuously or intermittently delivered to the cell culture for diluting concentration of at least one marker component in the cell culture. The concentration of the marker component may be measured continuously or intermittently to determined the culture media delivery rate. | 11-22-2012 |
20120259211 | SYSTEMS, DEVICES, AND METHODS EMPLOYING FIBER OPTIC SHAPE TRACKING - The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of the shape and position of objects whose shape dynamically changes with time. Applications include tracking and monitoring of endoscopes for diagnostic and surgical procedures. | 10-11-2012 |
20120180143 | TRANSGENIC ANIMAL MODEL OF NEURODEGENERATIVE DISORDERS - The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for provide a system for the development and testing of potential treatments. | 07-12-2012 |
20120164055 | METHOD OF REMOVAL OF IMPURITIES FROM SILICON - A method for the purification of metallurgical grade silicon is provided, which can be used to produce high purity silicon up to and including solar grade. The process relies on alloying and controlled solidification of Si with another metal, such as copper, zinc, iron, tin, nickel and aluminum, to produce purified platelets of Si, while the impurities are trapped in a getter alloy. The Si platelets are then separated from the solidified alloy by a physical separation technique such as gravity or magnetic separation. The separated grains of Si may then be further cleaned by acid leaching. Pre-refining of metallurgical grade silicon or post-refining of the product may be performed, depending on the initial impurity content of the feedstock, to obtain Si that meets solar grade requirements. | 06-28-2012 |
20120156721 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY - This invention provides novel chemically modified mutant serine hydrolases that catalyze a transamidation and/or a transpeptidation and/or a transesterification reaction. The modified serine hydrolases have one or more amino acid residues in a subsite replaced with a cysteine, wherein the cysteine is modified by replacing the thiol hydrogen in the cysteine with a substituent group providing a thiol side chain comprising a moiety selected from the group consisting of a polar aromatic substituent, an alkyl amino group with a positive charge, and a glycoside. In particularly preferred embodiments, the substitutents include an oxazolidinone, a C | 06-21-2012 |
20120156703 | USE OF MIMECAN IN THE ASSESSMENT OF HEART FAILURE - The disclosure relates to assessing heart failure in vitro by measuring the concentration of the marker mimecan in a sample, and optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration of mimecan and the one or more other marker(s) to reference concentrations of this (or these) marker(s) as established in a reference population. The one or more markers may be selected from the group comprising a natriuretic peptide marker, a cardiac troponin marker, and a marker of inflammation. Also disclosed are the use of mimecan as a marker protein in the assessment of heart failure, a marker combination comprising mimecan, and a kit for measuring mimecan. | 06-21-2012 |
20120085645 | DIGITAL MICROFLUIDIC LIQUID-LIQUID EXTRACTION DEVICE AND METHOD OF USE THEREOF - Methods and devices for liquid-liquid extraction using digital microfluidic arrays are provided. A polar droplet is transported to a separation region containing a substantially non-polar solvent, where non-polar impurities may be extracted from the polar droplet while maintaining a distinct phase separation. In a preferred embodiment, biological samples containing hormones are dried on a digital microfluidic array, lysed by a lysing solvent, dried, subsequently dissolved in a polar solvent, and further purified in a separation step in which droplets are transported through a volume of non-polar solvent. The method disclosed herein provides the distinct advantage of an automated sample preparation method that is capable of extracting hormones from low sample volumes with high precision and recovery. | 04-12-2012 |
20120083046 | HYBRID DIGITAL AND CHANNEL MICROFLUIDIC DEVICES AND METHODS OF USE THEREOF - The present invention provides a hybrid digital and channel microfluidic device in the form of an integrated structure in which a droplet may be transported by a digital microfluidic array and transferred to a microfluidic channel. In one aspect of the invention, a hybrid device comprises a first substrate having a digital microfluidic array capable of transporting a droplet to a transfer location, and a second substrate having a microfluidic channel. The first and second substrates are affixed to form a hybrid device in which an opening in the microfluidic channel is positioned adjacent to the transfer location, so that a droplet transported to the transfer location contacts the channel opening and may enter the channel. The invention also provides methods of performing separations using a hybrid digital and channel microfluidic device and methods of assembling a hybrid digital microfluidic device. | 04-05-2012 |
20120065366 | CYCLIC AMINO ACID MOLECULES AND METHODS OF PREPARING THE SAME - Macrocyclization of amino acids or linear peptides upon reaction with amphoteric amino aldehydes and isocyanides is provided. | 03-15-2012 |
20120000379 | METHOD FOR PRODUCING A STAMP FOR HOT EMBOSSING - The present invention provides a process for producing a stamp for hot embossing (HE). The stamp can be constructed from any photo-resist epoxy that is stable at temperatures equal to the glass transition temperature (T | 01-05-2012 |
20110297217 | PHOTOVOLTAIC DEVICES WITH MULTIPLE JUNCTIONS SEPARATED BY A GRADED RECOMBINATION LAYER - A recombination layer with a gradient work function is provided which increases the power-conversion efficiency of multijunction photovoltaic devices by reducing the energy barrier to charge carriers migrating between pairs of photovoltaic junctions thereby facilitating the optimal recombination of opposing electron and hole currents generated when the photovoltaic is illuminated. | 12-08-2011 |
20110287469 | DEVICE FOR INVESTIGATION OF A FLOW CONDUIT - A device for investigation of a flow conduit comprising: a base; and a module formed in the base, the module comprising: a main channel for the flow conduit, the main channel having a loading inlet for loading the flow conduit; a culture chamber in the main channel for at least one of perfusion and superfusion of the flow conduit; at least two fixation lines in communication with the main channel for providing fixation of the flow conduit at at least two fixation locations along the length of the flow conduit. | 11-24-2011 |
20110283653 | Fork Configuration Dampers and Method of Using Same - A damping system including a first set of plates having one end thereof attached to a first vertically extending structural element, a second set of plates having one end thereof attached to a second vertically extending structural element spaced in a horizontal direction from the first vertically extending structural element, and arranged such that the first set of plates has a second end portion extending towards and overlapping with a second end portion of the second set of plates at an overlapping region, and further including an energy dissipating material provided in the overlapping region for connecting the first set of plates and the second set of plates. | 11-24-2011 |
20110240471 | EXCHANGEABLE CARRIERS PRE-LOADED WITH REAGENT DEPOTS FOR DIGITAL MICROFLUIDICS - The present invention provides exchangeable, reagent pre-loaded carriers ( | 10-06-2011 |
20110240106 | PHOTOVOLTAIC DEVICES WITH DEPLETED HETEROJUNCTIONS AND SHELL-PASSIVATED NANOPARTICLES - Photovoltaic cells are fabricated in which the compositions of the light-absorbing layer and the electron-accepting layer are selected such that at least one side of the junction between these two layers is substantially depleted of charge carriers, i.e., both free electrons and free holes, in the absence of solar illumination. In further aspects of the invention, the light-absorbing layer is comprised of dual-shell passivated quantum dots, each having a quantum dot core with surface anions, an inner shell containing cations to passivate the core surface anions, and an outer shell to passivate the inner shell anions and anions on the core surface. | 10-06-2011 |
20110233075 | NANOSTRUCTURED MICROELECTRODES AND BIOSENSING DEVICES INCORPORATING THE SAME - Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein. | 09-29-2011 |
20100172803 | METHOD AND APPARATUS FOR FLUID DISPERSION - A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques. | 07-08-2010 |
20100150880 | Isolated mesenchymal cell population and method for isolating and using same - The present invention provides a novel isolated mesenchymal cell population of highly purified osteoprogenitors (HipOPs) that can be used in the formation of bone tissue and methods for isolating and using same. | 06-17-2010 |
20100150511 | Compressible Photonic Crystal - A compressible photonic crystal comprising a polymer with an ordered array of voids, the photonic crystal having a reflectance in a first wavelength range for light incident to its incident surface and its opposing incident surface; wherein compression against at least a portion of at least one of the surfaces shifts the reflectance to a second wavelength range in at least that portion of that surface. The crystal may be used in authentication devices of various types. | 06-17-2010 |
20100145087 | IRON(II) CATALYSTS CONTAINING DIIMINO-DIPHOSPHINE TETRADENTATE LIGANDS AND THEIR SYNTHESIS - New hexa-coordinate iron (II) complexes comprising compounds of formula (I) are described. These compounds comprise a tetradentate ligand with donor atoms comprising nitrogen and phosphorus. These complexes are shown for the first time to be useful catalysts for the hydrogenation of ketones, aldehydes, or imines to produce alcohols or amines, and the asymmetric hydrogenation of prochiral ketones or imines to produce non-racemic alcohols or amines. The source of the hydrogen can be hydrogen gas or a hydrogen-donating molecule such as isopropanol or hydrogen-donating mixture such as formic acid and an amine depending on the structure of the catalyst. In certain embodiments, the axial ligands on the catalyst comprise organonitrile ligands, carbonyl ligands, isonitrile ligands, or combinations thereof. The catalysts and the preparation thereof are disclosed. A reaction using phosphine and diamine precursors that is templated by the iron ion is the preferred route to the catalysts. | 06-10-2010 |
20100016234 | SIGNAL PEPTIDES, NUCLEIC ACID MOLECULES AND METHODS FOR TREATMENT OF CARIES - Compounds that competitively inhibit binding of CSP to | 01-21-2010 |
20090257715 | DYNAMIC WAVEFORM SHAPING IN A CONTINUOUS FIBER - A system for dynamic waveform shaping in an optical fiber comprising: the optical fiber receiving an optical waveform, the optical waveform having individual spectral lines; a plurality of fiber bragg gratings in-line on the optical fiber, each having a reflectivity wavelength corresponding to one of the spectral lines; a plurality of polarization controllers in-line on the optical fiber, each polarization controller receiving the optical waveform from a respective fiber bragg grating; a circulator for directing the optical waveform as input to the plurality of fiber bragg gratings and receiving the optical waveform as output from the plurality of fiber bragg gratings; and a polarizer in-line on the optical fiber receiving the optical waveform from the fiber bragg gratings and the polarization controllers. | 10-15-2009 |
20090191650 | ANTIBODY SPECIFIC FOR MUTANT PRESENILIN 1 AND METHOD OF USE THEREOF - The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the construction of transgenic animals expressing the mutant genes. | 07-30-2009 |
20080224103 | WIDELY WAVELENGTH TUNEABLE POLYCHROME COLLOIDAL PHOTONIC CRYSTAL DEVICE - The present invention discloses a widely wavelength tunable polychrome colloidal photonic crystal device whose optical Bragg diffraction stop bands and higher energy bands wavelength, width and intensity can be tuned in a continuous and fine, rapid and reversible, reproducible and predictable fashion and over a broad spectral range by a controlled expansion or contraction of the colloidal photonic lattice dimension, effected by a predetermined change in the electronic configuration of the composite material. In its preferred embodiment, the material is a composite in the form of a film or a patterned film or shape of any dimension or array of shapes of any dimension comprised of an organized array of microspheres in a matrix of a cross-linked metallopolymer network with a continuously variable redox state of charge and fluid content. The chemo-mechanical and electro-mechanical optical response of the colloidal photonic crystal-metallopolymer gel is exceptionally fast and reversible, attaining its fully swollen state from the dry shrunken state and vice versa on a sub-second time-scale. These composite materials can be inverted by removal of the constituent microspheres from the aforementioned colloidal photonic crystal metallopolymer-gel network to create a macroporous metallopolymer-gel network inverse colloidal photonic crystal film or patterned film or shape of any dimension optical Bragg diffraction stop bands and higher energy bands wavelength, width and intensity can be redox tuned in a continuous and fine, rapid and reversible, reproducible and predictable fashion and over a broad spectral range by a controlled expansion or contraction of the colloidal photonic lattice dimensions. | 09-18-2008 |