| The Governing Council of the University of Toronto Patent applications |
| Patent application number | Title | Published |
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| 20120085645 | DIGITAL MICROFLUIDIC LIQUID-LIQUID EXTRACTION DEVICE AND METHOD OF USE THEREOF - Methods and devices for liquid-liquid extraction using digital microfluidic arrays are provided. A polar droplet is transported to a separation region containing a substantially non-polar solvent, where non-polar impurities may be extracted from the polar droplet while maintaining a distinct phase separation. In a preferred embodiment, biological samples containing hormones are dried on a digital microfluidic array, lysed by a lysing solvent, dried, subsequently dissolved in a polar solvent, and further purified in a separation step in which droplets are transported through a volume of non-polar solvent. The method disclosed herein provides the distinct advantage of an automated sample preparation method that is capable of extracting hormones from low sample volumes with high precision and recovery. | 04-12-2012 |
| 20120083046 | HYBRID DIGITAL AND CHANNEL MICROFLUIDIC DEVICES AND METHODS OF USE THEREOF - The present invention provides a hybrid digital and channel microfluidic device in the form of an integrated structure in which a droplet may be transported by a digital microfluidic array and transferred to a microfluidic channel. In one aspect of the invention, a hybrid device comprises a first substrate having a digital microfluidic array capable of transporting a droplet to a transfer location, and a second substrate having a microfluidic channel. The first and second substrates are affixed to form a hybrid device in which an opening in the microfluidic channel is positioned adjacent to the transfer location, so that a droplet transported to the transfer location contacts the channel opening and may enter the channel. The invention also provides methods of performing separations using a hybrid digital and channel microfluidic device and methods of assembling a hybrid digital microfluidic device. | 04-05-2012 |
| 20120065366 | CYCLIC AMINO ACID MOLECULES AND METHODS OF PREPARING THE SAME - Macrocyclization of amino acids or linear peptides upon reaction with amphoteric amino aldehydes and isocyanides is provided. | 03-15-2012 |
| 20120000379 | METHOD FOR PRODUCING A STAMP FOR HOT EMBOSSING - The present invention provides a process for producing a stamp for hot embossing (HE). The stamp can be constructed from any photo-resist epoxy that is stable at temperatures equal to the glass transition temperature (T | 01-05-2012 |
| 20110297217 | PHOTOVOLTAIC DEVICES WITH MULTIPLE JUNCTIONS SEPARATED BY A GRADED RECOMBINATION LAYER - A recombination layer with a gradient work function is provided which increases the power-conversion efficiency of multijunction photovoltaic devices by reducing the energy barrier to charge carriers migrating between pairs of photovoltaic junctions thereby facilitating the optimal recombination of opposing electron and hole currents generated when the photovoltaic is illuminated. | 12-08-2011 |
| 20110287469 | DEVICE FOR INVESTIGATION OF A FLOW CONDUIT - A device for investigation of a flow conduit comprising: a base; and a module formed in the base, the module comprising: a main channel for the flow conduit, the main channel having a loading inlet for loading the flow conduit; a culture chamber in the main channel for at least one of perfusion and superfusion of the flow conduit; at least two fixation lines in communication with the main channel for providing fixation of the flow conduit at at least two fixation locations along the length of the flow conduit. | 11-24-2011 |
| 20110283653 | Fork Configuration Dampers and Method of Using Same - A damping system including a first set of plates having one end thereof attached to a first vertically extending structural element, a second set of plates having one end thereof attached to a second vertically extending structural element spaced in a horizontal direction from the first vertically extending structural element, and arranged such that the first set of plates has a second end portion extending towards and overlapping with a second end portion of the second set of plates at an overlapping region, and further including an energy dissipating material provided in the overlapping region for connecting the first set of plates and the second set of plates. | 11-24-2011 |
| 20110240471 | EXCHANGEABLE CARRIERS PRE-LOADED WITH REAGENT DEPOTS FOR DIGITAL MICROFLUIDICS - The present invention provides exchangeable, reagent pre-loaded carriers ( | 10-06-2011 |
| 20110240106 | PHOTOVOLTAIC DEVICES WITH DEPLETED HETEROJUNCTIONS AND SHELL-PASSIVATED NANOPARTICLES - Photovoltaic cells are fabricated in which the compositions of the light-absorbing layer and the electron-accepting layer are selected such that at least one side of the junction between these two layers is substantially depleted of charge carriers, i.e., both free electrons and free holes, in the absence of solar illumination. In further aspects of the invention, the light-absorbing layer is comprised of dual-shell passivated quantum dots, each having a quantum dot core with surface anions, an inner shell containing cations to passivate the core surface anions, and an outer shell to passivate the inner shell anions and anions on the core surface. | 10-06-2011 |
| 20110233075 | NANOSTRUCTURED MICROELECTRODES AND BIOSENSING DEVICES INCORPORATING THE SAME - Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein. | 09-29-2011 |
| 20100172803 | METHOD AND APPARATUS FOR FLUID DISPERSION - A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques. | 07-08-2010 |
| 20100150880 | Isolated mesenchymal cell population and method for isolating and using same - The present invention provides a novel isolated mesenchymal cell population of highly purified osteoprogenitors (HipOPs) that can be used in the formation of bone tissue and methods for isolating and using same. | 06-17-2010 |
| 20100150511 | Compressible Photonic Crystal - A compressible photonic crystal comprising a polymer with an ordered array of voids, the photonic crystal having a reflectance in a first wavelength range for light incident to its incident surface and its opposing incident surface; wherein compression against at least a portion of at least one of the surfaces shifts the reflectance to a second wavelength range in at least that portion of that surface. The crystal may be used in authentication devices of various types. | 06-17-2010 |
| 20100145087 | IRON(II) CATALYSTS CONTAINING DIIMINO-DIPHOSPHINE TETRADENTATE LIGANDS AND THEIR SYNTHESIS - New hexa-coordinate iron (II) complexes comprising compounds of formula (I) are described. These compounds comprise a tetradentate ligand with donor atoms comprising nitrogen and phosphorus. These complexes are shown for the first time to be useful catalysts for the hydrogenation of ketones, aldehydes, or imines to produce alcohols or amines, and the asymmetric hydrogenation of prochiral ketones or imines to produce non-racemic alcohols or amines. The source of the hydrogen can be hydrogen gas or a hydrogen-donating molecule such as isopropanol or hydrogen-donating mixture such as formic acid and an amine depending on the structure of the catalyst. In certain embodiments, the axial ligands on the catalyst comprise organonitrile ligands, carbonyl ligands, isonitrile ligands, or combinations thereof. The catalysts and the preparation thereof are disclosed. A reaction using phosphine and diamine precursors that is templated by the iron ion is the preferred route to the catalysts. | 06-10-2010 |
| 20100016234 | SIGNAL PEPTIDES, NUCLEIC ACID MOLECULES AND METHODS FOR TREATMENT OF CARIES - Compounds that competitively inhibit binding of CSP to | 01-21-2010 |
| 20090257715 | DYNAMIC WAVEFORM SHAPING IN A CONTINUOUS FIBER - A system for dynamic waveform shaping in an optical fiber comprising: the optical fiber receiving an optical waveform, the optical waveform having individual spectral lines; a plurality of fiber bragg gratings in-line on the optical fiber, each having a reflectivity wavelength corresponding to one of the spectral lines; a plurality of polarization controllers in-line on the optical fiber, each polarization controller receiving the optical waveform from a respective fiber bragg grating; a circulator for directing the optical waveform as input to the plurality of fiber bragg gratings and receiving the optical waveform as output from the plurality of fiber bragg gratings; and a polarizer in-line on the optical fiber receiving the optical waveform from the fiber bragg gratings and the polarization controllers. | 10-15-2009 |
| 20090191650 | ANTIBODY SPECIFIC FOR MUTANT PRESENILIN 1 AND METHOD OF USE THEREOF - The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the construction of transgenic animals expressing the mutant genes. | 07-30-2009 |
| 20080224103 | WIDELY WAVELENGTH TUNEABLE POLYCHROME COLLOIDAL PHOTONIC CRYSTAL DEVICE - The present invention discloses a widely wavelength tunable polychrome colloidal photonic crystal device whose optical Bragg diffraction stop bands and higher energy bands wavelength, width and intensity can be tuned in a continuous and fine, rapid and reversible, reproducible and predictable fashion and over a broad spectral range by a controlled expansion or contraction of the colloidal photonic lattice dimension, effected by a predetermined change in the electronic configuration of the composite material. In its preferred embodiment, the material is a composite in the form of a film or a patterned film or shape of any dimension or array of shapes of any dimension comprised of an organized array of microspheres in a matrix of a cross-linked metallopolymer network with a continuously variable redox state of charge and fluid content. The chemo-mechanical and electro-mechanical optical response of the colloidal photonic crystal-metallopolymer gel is exceptionally fast and reversible, attaining its fully swollen state from the dry shrunken state and vice versa on a sub-second time-scale. These composite materials can be inverted by removal of the constituent microspheres from the aforementioned colloidal photonic crystal metallopolymer-gel network to create a macroporous metallopolymer-gel network inverse colloidal photonic crystal film or patterned film or shape of any dimension optical Bragg diffraction stop bands and higher energy bands wavelength, width and intensity can be redox tuned in a continuous and fine, rapid and reversible, reproducible and predictable fashion and over a broad spectral range by a controlled expansion or contraction of the colloidal photonic lattice dimensions. | 09-18-2008 |
