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The Gov. of the USA, as represented by the Uniformed Services University of Health Sciences

Bethesda, MD US

The Gov. of the USA, as represented by the Uniformed Services University of Health Sciences Patent applications
Patent application numberTitlePublished
20080311144MUTANT FORMS OF CHOLERA HOLOTOXIN AS AN ADJUVANT - Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.12-18-2008