The Florida International University Board of Trustees Patent applications |
Patent application number | Title | Published |
20160139102 | PAPER MICROFLUIDIC DEVICES FOR DETECTION OF IMPROVISED EXPLOSIVES - Paper microfluidic devices for testing for explosives are provided, along with methods of fabricating and using the same. One or more channels are formed on a paper substrate, and a test spot is formed in at least one of the channels. The channels can be hydrophobic. A test reagent is provided in the test spot and tests for explosives. | 05-19-2016 |
20160138069 | Method for Detection of Pseudomonas Aeruginosa (PA) Using Volatile Biomarkers - A method of determining the presence of | 05-19-2016 |
20160131668 | MATERIALS AND METHODS FOR RAPID AND SPECIFIC DETECTION OF COCAINE - The invention pertains to a rapid and specific aptamer-based method for one-step cocaine detection with minimal reagent requirements based on an aptamer sensor that reports the presence of cocaine via the displacement and unquenching of a bound fluorophore molecule. In certain embodiments, the invention provides novel aptamers, which have reduced background fluorescence, bind a fluorophore molecule tightly, and show an increased signal gain in the presence of cocaine. | 05-12-2016 |
20160116426 | Nanotip Sensor - Embodiments of a nanotip sensor for detecting and identifying chemical or biological particulates in a sample are disclosed. The nanotip sensor may include a plurality of nanotips, each with a cathode, an anode, and a gap between the cathode and the anode. An adsorbed particulate from the sample may bridge the gap between the cathode and the anode, forming an electrical circuit. A conductive spectrum of the particulates in the sample that are adsorbed onto the nanotips of the sensor may be determined, and by comparing the conductive spectrum of the sample with conductive spectrums of known particulates, one or more specific particulates contained in the sample may be detected and identified. Techniques to augment the specificity of the sensor and to clean the sensor for re-use are disclosed. Embodiments of systems and methods that use the nanotip sensor to detect chemical and biological particulates are disclosed. | 04-28-2016 |
20160084830 | SURFACE PLASMON RESONANCE BASED SENSING DEVICES AND METHODS FOR REAL-TIME ANALYSIS OF ANALYTE SECRETION FROM LIVING CELLS - The present invention provides surface plasmon resonance (SPR) based sensing systems and methods for rapid, sensitive, and real-time analysis of analyte secretion from living cells. In one embodiment, the SPR based sensing device of the present invention comprises at least one cell culture module for culturing living cells, wherein the cell culture module is configured so that analytes secreted from the living cells can be released onto a SPR sensing surface. | 03-24-2016 |
20160055084 | NON-BLOCKING WRITES TO FILE DATA - Techniques and systems are disclosed for implementing non-blocking writes to eliminate the fetch-before-write requirement by creating an in-memory patch for the updated page and unblocking the calling process. Non-blocking writes eliminate such blocking by buffering the written data elsewhere in memory and unblocking the writing process immediately. Subsequent reads to the updated page locations are also made non-blocking and, in some cases, can be eliminated when the read request can be serviced from in-memory patches. | 02-25-2016 |
20160039962 | One-Pot Synthesis of Flexible Poly-P-(Phenyleneethynylene)s with Controlled Conjugated Length - A novel monomer design for the synthesis of PPE-type polymers containing conjugated segments of well-defined length connected by flexible linkers under Sonogashira reaction conditions is presented. The resulting polymers retain the photophysical properties of a fully conjugated PPE. The extent of incorporation of the flexible units along the backbone is governed by the comonomer feed ratio and can be varied in a statistically predictable fashion. | 02-11-2016 |
20160038754 | ELECTROCARDIOGRAPHY TRIGGERED TRANSCRANIAL MAGNETIC STIMULATION SYSTEMS AND METHODS OF USING THE SAME - Systems that integrate electrocardiography (ECG) functions and Transcranial Magnetic Stimulation (TMS) functions, as well as methods of manufacturing such systems and methods of performing ECG and TMS using such systems, are provided. A system can include a hardware component and a software component in operable communication with the hardware component. The hardware component can include or be in operable communication with a TMS machine, and the software component can be configured to receive waveforms from ECG hardware. | 02-11-2016 |
20160033653 | Chromotropic Detection of Ionizing Radiation - A high contrast dosimeter is constructed where a plastic support is at least partially coated with a layer having a colored radical trapping compound. The plastic is a polymer that can contain a radiation sensitive plasticizer. The plastic forms radicals upon irradiation with high-energy (low wavelength) radiation. Upon diffusion of the radicals to the layer of radical trapping compound, reaction forms a compound with a different color than the radical trapping compound. In an embodiment of the invention, the plastic support is celluloid and the radical trapping compound is an azulenyl nitrone (AZN). | 02-04-2016 |
20160018414 | SAB as a Biomarker for Degenerative Diseases and Therapeutic Sensitivity in Cancers - The current invention pertains to a method of diagnosing a disease or identifying an increased likelihood of developing the disease in a subject. The method comprises determining the level of Src homology 3 domain binding protein 5 (SH3BP5 or SAB) or the RNA encoding SAB protein in a biological sample obtained from the subject and identifying the subject as having the disease or having an increased likelihood of developing the disease if the biological sample obtained from the subject has an altered level of SAB protein or the RNA encoding SAB protein relative to a control sample. The methods of the current invention can be practiced to diagnose and treat a systemic degenerative disease, a neurodegenerative disease, obesity, diabetes, a cancer, or an aging related disease. The invention also provides a kit for diagnosing a disease or diagnosing an increased likelihood of developing the disease in a subject. | 01-21-2016 |
20160015994 | Hardware/Software Integrated Design for a 3D Tremor Detector Using TMS in Parkinson's Disease and Related Disorders - Systems that integrate Transcranial Stimulation Biofeedback (TSB) Detector functions and Transcranial Magnetic Stimulation (TMS) functions, as well as methods of manufacturing such systems and methods of performing TSB detection and TMS using such systems, are provided. A system can include a hardware component and a software component in operable communication with the hardware component. The hardware component can include or be in operable communication with a TMS machine, and the software component can be configured to receive waveforms from the TSB Detector hardware. | 01-21-2016 |
20150345472 | ACTIVE AERODYNAMICS MITIGATION AND POWER PRODUCTION SYSTEM FOR BUILDINGS AND OTHER STRUCTURES - The current invention provides apparatuses and methods for protecting buildings/structures from wind damage and simultaneously harvesting energy from wind. The apparatuses of the current invention comprise horizontal axial wind turbines integrated to the roof-edge of the buildings/structures in an aerodynamically conducive and structurally viable configuration to reduce roof suction. The apparatuses of the current invention can further comprise aerodynamic roof gutter and structural supports/connections to alleviate wind-induced suction (negative pressures) on building roofs generated by separated flows and vortices. The apparatuses of the current invention can also comprise vertical axial wind turbines integrated to the wall-edge of the structures/buildings in an aerodynamically conducive and structurally viable configuration to reduce wind induced wall suction generated by separated flows and vortices. | 12-03-2015 |
20150315647 | MICROBIOME GENE EXPRESSION AS A BIOMARKER OF ARSENIC EXPOSURE - The present invention provides methods and kits to screen for arsenic exposure. The methods and kits utilize quantitative (qPCR) and/or other bioassays to analyze levels of arsenic-inducible genes and reporter genes as biomarkers for exposure. | 11-05-2015 |
20150310671 | SYSTEMS AND METHODS FOR AUGMENTED REALITY INTERACTION - An augmented reality system is described that comprises a movable object comprising an object hardware component; a control hardware component for wirelessly transmitting and receiving signals via a communication link to the object hardware component; and a software component stored on a non-transitory computer-readable medium and in operable communication with the control hardware component. An application user interface is provided for enabling a user to provide command input for controlling the movement of the movable object via the object hardware component. | 10-29-2015 |
20150279646 | Method and Apparatus for Extraction, Detection, and Characterization of Vapors from Explosives, Taggants in Explosives, Controlled Substances, and Biohazards - An improved method of extraction, detection, and characterization of a vapor from an explosive, a taggant in an explosive, a controlled substance, a biohazard, and mixtures thereof uses a new and improved SPME device for extraction and ion mobility spectrometry for detection and characterization. The new and improved SPME device has an increased capacity to sorb a target vapor. The increased sorption of vapor provides for more accurate detection by an ion mobility spectrometer. A SPME device having increased surface area may be exposed to an atmosphere in an enclosure containing a test object or a volume of gas that was in contact with the test object to allow for sorption of the target vapor and then introduced into an IMS for more accurate detection and characterization of the vapor due to the increased sorption of the vapor by the SPME device described herein. | 10-01-2015 |
20150253323 | METHODS AND KITS FOR HIGH THROUGHPUT SCREENING FOR COMPOUNDS TARGETING DNA-BINDING AND RNA-BINDING PROTEINS - The present invention provides methods of screening compounds that inhibit or enable or activate or enhance the sequence-specific or nonspecific binding of a polynucleotide binding protein to a polynucleotide fragment. Also provided are enzyme linked immunosorbent assay (ELISA) kits for screening for compounds that inhibit or enable, activate, or enhance the sequence-specific or nonspecific binding of a polynucleotide binding protein. | 09-10-2015 |
20150247816 | LABEL-FREE ELECTROCHEMICAL BIOSENSOR - The current invention pertains to electrochemical biosensors. The electrochemical biosensor of the current invention comprises:
| 09-03-2015 |
20150190061 | NEAR-INFRARED OPTICAL IMAGING SYSTEM FOR HEMODYNAMIC IMAGING, PULSE MONITORING, AND MAPPING SPATIO-TEMPORAL FEATURES - The present application describes techniques to image biological tissue to determine biological information of an imaged tissue sample such as changes in hemoglobin concentrations, blood flow rate (pulse), and/or spatio-temporal features. Embodiments include illuminating the tissue sample with light in the near-infrared (NIR) spectrum, which is minimally absorbed but scattered through the tissue sample. By detecting the NIR light that is attenuated through, transmitted through, and/or reflected off the tissue to be imaged, the resulting NIR intensity signals may be further analyzed to provide this data. Embodiments include using multiple NIR light sources having varying wavelengths to obtain changes in the oxy- and deoxy-hemoglobin concentrations of the imaged tissue region. The tissue sample may be imaged over a time period, and the NIR images may be viewed statically or in real time after post-processing analyses have been performed. | 07-09-2015 |
20140364743 | NEAR-INFRARED (NIR) OPTICAL SCANNER - A method, apparatus, and system acquire data to create a 3D mesh representing a 3D object. The method, apparatus, and system acquire image data of the 3D object using an imaging probe that includes illumination and detection capability. A light source operates to illuminate the 3D object for reflection and/or trans-illumination imaging, and a detection assembly receives image reflection and/or trans-illumination image data. The reflectance and trans-illumination image data collected by the detection assembly are co-registered with a previously acquired 3D mesh using data from a tracking system monitoring the position of the probe, displayed in real-time, and optionally saved. | 12-11-2014 |
20140330404 | SYSTEMS AND METHODS FOR DECODING INTENDED MOTOR COMMANDS FROM RECORDED NEURAL SIGNALS FOR THE CONTROL OF EXTERNAL DEVICES OR TO INTERACT IN VIRTUAL ENVIRONMENTS - Systems and methods for decoding neural and/or electromyographic signals are provided. A system can include at least one single channel decoder. Optionally, the system can include a demixer in operable communication with the single channel decoders. Each single channel decoder can include a filter to attenuate noise and sharpen spikes in the neural and/or electromyographic signals, a detection function to identify spikes, and a demodulator to get a real-time estimate of motor intent. | 11-06-2014 |
20140330102 | LOW NOISE ANALOG ELECTRONIC CIRCUIT DESIGN FOR RECORDING PERIPHERAL NERVE ACTIVITY - Circuits and circuit systems to record activity (e.g., peripheral nerve activity) are provided. The circuits advantageously have good noise characteristics (e.g., low noise), as well as low power consumption and low area. A circuit can be implantable (e.g., in a human subject). Methods of designing, manufacturing, and using such circuits and circuit systems are also provided. | 11-06-2014 |
20140314890 | COMBINATION ANTI-CANCER THERAPY - Discloses herein is a combination therapy for treating cancer by administration of a phycocyanin and a chemotherapeutic. | 10-23-2014 |
20140280319 | STREAMING REPRESENTATION OF MOVING OBJECTS AND SHAPES IN A GEOGRAPHIC INFORMATION SERVICE - A geographical information system (GIS) is described that enables querying, analysis and visualization of real-time streaming data pertaining to at least one moving object or entity (e.g., vehicles, people, sensors, weather phenomena, etc.) in conjunction with relatively static multi-temporal geospatial data. An application programming interface is provided to present the GIS functionality for handling dynamically moving objects or entities to clients. | 09-18-2014 |
20140277583 | FITTING SYSTEM FOR A NEURAL ENABLED LIMB PROSTHESIS SYSTEM - Fitting systems and fitting methods for prostheses are provided. An instrumented prosthesis (IP), such as an instrumented prosthetic hand (IPH), can include sensors and can be connected to a neural stimulation system (NSS) or neural recording system (NRS), which includes an implanted system having electrodes. The NSS/NRS can also be connected to a software module, which can assist in calibrating the electrodes and mapping sensor values to stimulation parameters and/or mapping motor intent from recorded neural activity to control of prostheses. | 09-18-2014 |
20140274660 | FABRIC PHASE SORPTIVE EXTRACTORS (FPSE) - A fabric phase sorptive extractor (FPSE) is a sampling device where a flexible fabric is coated with at least one sol-gel derived film that includes at least two of a metal oxide portion, a siloxy portion, and an organic portion, where the gel has at least some amorphous portions. The FPSE is flexible such that it can be used in an extended form or draped over a solid surface to contact a gaseous, liquid, or solid environment and can be manipulated for placement in a container where the absorbed analyte can be removed from the FPSE for instrumental analysis. The FPSE can have specific functionalities that bind to specific analytes or can provide a general sorbent medium for extraction of a wide range of analytes, such that the sampling device can be employed for sampling analytes with biological, environmental, food, pharmaceutical, bio-analytical, clinical, forensic, toxicological, national security, public health, and/or safety implications. | 09-18-2014 |
20140268159 | SURFACE PLASMON RESONANCE BASED SENSING DEVICES AND METHODS FOR REAL-TIME ANALYSIS OF ANALYTE SECRETION FROM LIVING CELLS - The present invention provides surface plasmon resonance (SPR) based sensing systems and methods for rapid, sensitive, and real-time analysis of analyte secretion from living cells. In one embodiment, the SPR based sensing device of the present invention comprises at least one cell culture module for culturing living cells, wherein the cell culture module is configured so that analytes secreted from the living cells can be released onto a SPR sensing surface. | 09-18-2014 |
20140260974 | CAPILLARY MICROEXTRACTOR OF VOLATILES (CMV) - A capillary microextractor of volatiles (CMV) allows the sampling of diagnostic volatiles that can be an explosive, explosive taggant, drug, poison, decomposition products thereof, a mixture of chemicals comprising an odor signature determined from detector dog trials, or volatile organic compounds indicative of a disease or other medical condition. The CMV has a thermally stable housing with orifices to allow the contact of a gas that contains one or more diagnostic volatiles with an absorbent that extracts and concentrates the diagnostic volatiles. After sampling, the CMV with the absorbed diagnostic volatiles can be placed in an ionized gas beam and introduced into a mass spectrometer or placed in a thermal desorption unit (TDU), where, upon heating, the diagnostic volatiles are released to an inlet port of an analytical instrument. Analytical instruments that can be used include gas chromatographs and ion mobility spectrometers for separation and mass spectrometers for unambiguous identification of the diagnostic volatiles. | 09-18-2014 |
20140236882 | GEOLOCATING SOCIAL MEDIA - Techniques for geolocating social media are described. According to an embodiment, information from textual content of a non-geolocated social media data item stored in a database is extracted. A knowledge database is then searched for a cluster of geo-located social media data items to which the information most closely relates, and an estimated location is assigned to the non-geolocated social media data item according to the cluster to which the information most closely relates. Each cluster comprises one or more representative tags for a spatio-temporal region. The knowledge database is created from geolocated social media data by grouping data according to location and extracting representative tags from the location's grouping of data according to textual content as well as information related to reliability and truthfulness of the textual content. | 08-21-2014 |
20140220839 | Out-of-Autoclave Curing System - A method for bonding two parts together in accordance with an embodiment of the disclosure can include providing first and second parts, placing a light curable adhesive between the first and second parts, and irradiating the light curable adhesive using a modified fiber optic filament disposed between the first and second parts. | 08-07-2014 |
20140165487 | WIND RESISTANT CONCRETE ROOF COMPONENT AND SYSTEM AND METHOD FOR FORMING SAME - A roof system includes a roof panel formed of concrete and an architectural surface such as a corrugated surface. A first layer of reinforcing material is disposed along and spaced inwardly from a first surface of the roof panel, and an optional second layer of reinforcing material is disposed along and spaced inwardly from a second surface of the roof panel. The first layer of reinforcing material is spaced from the second layer of reinforcing material. The reinforcing material may be formed of fiber-reinforced polymer mesh, made with carbon fibers or glass fibers. FRP rebar may be used in conjunction with FRP mesh to provide added structural strength. The roof panel may include one or more elongated ribs having a thickness greater than adjacent portions of the roof panel. In other aspects, concrete structures with reinforcing material may be used for either roof panels or wall applications. | 06-19-2014 |
20140128951 | Modular Multi-Channel Inline Connector System - A modular multi-channel inline connector system that connects an implanted electrode within a body of an organism, such as the human body, with a device located external to or implanted within the body. The modular multi-channel inline system comprises of a first lead operatively connected to the implanted electrode and to a first connector portion. A second lead is operatively connected to a second connector portion and operatively connected to the device. One of the first and second connector portions comprises a male connector and the other of the first and second connector portions comprises a female connector. The first and second connector portions are arranged to connect with each other and to be operatively located embedded within the body. | 05-08-2014 |
20140128950 | MULTI-LEAD MULTI-ELECTRODE MANAGEMENT SYSTEM - A multi-lead multi-electrode system and method of manufacturing the multi-lead multi-electrode system includes a multi-electrode lead that may be used to deploy multiple separable electrodes to different spaced apart contact sites, such as nerve or muscle tissues, for example, that are spatially distributed over a large area. | 05-08-2014 |
20140128446 | 2-Methylthiopyrrolidines and Their Use for Modulating Bacterial Quorum Sensing - Compounds of Formula (I) are disclosed herein and their use in inhibiting quorum sensing in bacteria. | 05-08-2014 |
20140059515 | COMMUNICATION VIRTUAL MACHINE - A system for automating at least a portion of a communication application development cycle using a communication virtual machine that automatically interfaces with an existing network system and provides an engine for executing designed application models over the existing network system. | 02-27-2014 |
20140031253 | Protein Detection Using Three-Dimensional Carbon Microarrays - The potential of aptamers as ligand binding molecule have opened new avenues in the development of biosensors for proteins, such as cancer oncoproteins. Disclosed herein is a label-free detection strategy using signaling aptamer/protein binding complex for proteins, such as platelet-derived growth factor (PDGF-BB) oncoprotein. The detection mechanism is based on the release of a fluorophore (e.g., TOTO intercalating dye) from the target binding aptamer's stem structure when it captures the protein, e.g., PDGF. Amino-terminated three-dimensional carbon microarrays fabricated by pyrolyzing patterned photoresist are used as a detection platform. The sensor showed near linear relationship between the relative fluorescence difference and protein concentration even in the sub-nanomolar range with an excellent detection limit of 5 pmol. This detection strategy is promising in a wide range of applications in the detection of cancer biomarkers and other proteins. | 01-30-2014 |
20140029161 | ELECTROCHEMICALLY ACTIVATED C-MEMS ELECTRODES FOR ON-CHIP MICRO-SUPERCAPACITORS - Disclosed herein are methods of manufacturing micro-super capacitors from C-MEMS structures. | 01-30-2014 |
20130317094 | USE OF ELLAGITANNINS AS INHIBITORS OF BACTERIAL QUORUM SENSING - Described herein are materials and methods for the inhibition of bacterial QS. Methods of treating bacterial infections by administration of one or more ellagitannins in amount effective to inhibit bacterial QS is also provided. | 11-28-2013 |
20130252273 | ORGANOMETALLIC FLUORESCENT SENSORS FOR NITRIC OXIDE DETECTION AND IMAGING - Disclosed herein are methods of detecting the presence and/or concentration of nitric oxide using organometallic complexes and changes in fluorescence. | 09-26-2013 |
20130245759 | MEDICAL DEVICES INCORPORATING SILICONE NANOPARTICLES, AND USES THEREOF - Provided herein are uses of silicone nanoparticles as breast implant materials that reduce immunogenic responses, compared to other breast implant materials. | 09-19-2013 |
20130169759 | Second Generation Hand Held Optical Imager - A method, apparatus, and system acquire data to create a 3D mesh representing a 3D object. The method, apparatus, and system acquire image data of the 3D object using two probes of an imaging system. The flexible probes conform to the shape of the 3D object, illuminate the object at a face of each probe head via optical fibers coupled to an illumination system, and receive at the surface of the 3D object, via optical fibers coupled to a detection system, light reflected from and/or transmitted through the 3D object. The reflectance and transillumination image data collected by the detection system are co-registered with the previously acquired 3D mesh using data from a tracking system monitoring the position of each probe, displayed in real-time, and optionally saved. | 07-04-2013 |
20130136808 | PLANT-DERIVED FORMULATIONS FOR TREATMENT OF HIV - Disclosed herein are methods for treating mammals with HIV/AIDS comprising administering a therapeutically effective amount of a composition comprising an extract of | 05-30-2013 |
20120210948 | UNIVERSAL DETECTOR CALIBRANT - A method of calibrating a biological detector can include training a biological detector to detect a calibration compound, wherein the calibration compound comprises an odor that is detectable by the biological detector and is not used in an environment for which the biological detector is trained to detect odors, presenting the biological detector with a device comprising the calibration compound, and determining whether the biological detector will alert to the calibration compound. | 08-23-2012 |
20110295361 | Catheter Deliverable Artificial Multi-Leaflet Heart Valve Prosthesis and Intravascular Delivery System for a Catheter Deliverable Heart Valve Prosthesis - A heart valve prosthesis includes a collapsible stent and a one-piece multi-leaflet valve. The stent includes at least one length of wire having a series of turns forming a spring-like stent. The one-piece multi-leaflet valve is attached to the stent and includes a cylinder of polyester material secured thereto at three points. The stent is collapsible in a radial direction between a contracted state and an expanded state. The contracted state has a radial dimension smaller than a radial dimension of the expanded state. The stent is spring biased toward the expanded state such that it occupies an active state when implanted into a heart. The active state has a radial dimension that is between the radial dimension of the contracted state and the radial dimension of the expanded state such that a radial load generated by the bias of the collapsible stent is sufficient to retain the heart valve prosthesis in the heart. | 12-01-2011 |
20110213193 | Magnetic Nanodelivery of Therapeutic Agents Across the Blood Brain Barrier - Liposomes comprising magnetic nanoparticles bound to one or more therapeutic agents are disclosed herein. Also disclosed are methods of delivering a therapeutic agent to a patient across the blood brain barrier using these liposomes, and optionally applying an external magnetic field. | 09-01-2011 |
20110105421 | ELLAGITANNINS AS INHIBITORS OF BACTERIAL QUORUM SENSING - Described herein are materials and methods for the inhibition of bacterial QS. Methods of treating bacterial infections by administration of one or more ellagitannins in amount effective to inhibit bacterial QS is also provided. | 05-05-2011 |
20100155599 | Hand-Held Optical Probe Based Imaging System with 3D Tracking Facilities - A method, apparatus, and system display image data for a three-dimensional object in real-time, co-registering the image data acquired from a probe with the location on the three-dimensional object from which the image data was acquired, by tracking the position and orientation of the probe as the probe acquires the image data. | 06-24-2010 |
20100101956 | NANOSCALE DNA DETECTION SYSTEM USING SPECIES-SPECIFIC AND/OR DISEASE- SPECIFIC PROBES FOR RAPID IDENTIFICATION - A method and system for detecting a DNA strand using carbon nanotubes or nanowires. A specific single strand of template DNA serves as a probe for its complementary strand in a solution containing DNA segments to be tested. The single-stranded sequence-specific DNA probe segment, whose ends are modified with amine, is attached between two carbon nanotubes/nanowires. When complementary strands representing DNA segments under test are brought near the probe strands, a dielectrophoresis (DEP) field may enhance the probability of selective hybridization between the complimentary target DNA and probe DNA. A change in electrical conductance in the probe strand occurs upon hybridization of the complementary target DNA with the single probe strand. This conductance change may be measured using the two carbon nanotubes or nano-dimensional electrodes. By exploiting nano-dimensional electrodes and single strand probe DNA, the proposed system is capable of accurately detecting a single molecule of DNA. | 04-29-2010 |
20100016349 | PSEUDOAZULENYL NITRONES - Disclosed herein are pseudoazulenyl nitrone compounds and methods of using these compounds to trap free radicals and to treat, prevent, or ameliorate various diseases associated with free radicals. | 01-21-2010 |
20090309016 | Method and apparatus for Detecting Explosives - An interface that couples SPME to IMS has been constructed and evaluated for the detection of the following detection taggants: 2-nitrotoluene (2-NT), 4-nitrotoluene (4-NT), and 2,3-dimethyl-2,3-dinitrobutane (DMNB). The interface was also evaluated for the following common explosives: smokeless powder (nitrocellulose, NC), 2,4-dinitrotoluene (2,4-DNT), 2,6-dinitrotoluene (2,6-DNT), 2,4,6-trinitrotoluene (2,4,6-TNT), hexahydro-1,3,5-trinitro-s-triazine (RDX), and pentaerythritol tetranitrate (PETN). The resultant SPME-IMS interface was found to extract volatile constituent chemicals and detection taggants in explosives from a headspace for subsequent detection in a simple, rapid, sensitive, and inexpensive manner. | 12-17-2009 |
20090155850 | Horse:Human Chimeric Antibodies - The present invention provides a plurality of chimeric single chain variable region (scFv) antibodies. The chimeric scFv antibodies individually comprise variable regions from both horse and non-horse antibodies. Methods of making and using the plurality are also provided. | 06-18-2009 |
20090112309 | Collapsible Heart Valve with Polymer Leaflets - A Catheter Based Heart Valve (CBHV) is described herein which replaces a non functional, natural heart valve. The CBHV significantly reduces the invasiveness of the implantation procedure by being inserted with a catheter as opposed to open heart surgery. Additionally, the CBHV is coated with a biocompatible material to reduce the thrombogenic effects and to increase durability of the CBHV. The CBHV includes a stent and two or more polymer leaflets sewn to the stent. The stent is a wire assembly coated with Polystyrene-Polyisobutylene-Polystyrene (SIBS). The leaflets are made from a polyester weave as a core material and are coated with SIBS before being sewn to the stent. Other biocompatible materials may be used, such as stainless steel, Titanium, Nickel-Titanium alloys, etc. | 04-30-2009 |
20090084201 | METHOD AND APPARATUS FOR EXTRACTION, DETECTION, AND CHARACTERIZATION OF VAPORS FROM EXPLOSIVES, TAGGANTS IN EXPLOSIVES, CONTROLLED SUBSTANCES, AND BIOHAZARDS - An improved method of extraction, detection, and characterization of a vapor from an explosive, a taggant in an explosive, a controlled substance, a biohazard, and mixtures thereof uses a new and improved SPME device for extraction and ion mobility spectrometry for detection and characterization. The new and improved SPME device has an increased capacity to sorb a target vapor. The increased sorption of vapor provides for more accurate detection by an ion mobility spectrometer. A SPME device having increased surface area may be exposed to an atmosphere in an enclosure containing a test object or a volume of gas that was in contact with the test object to allow for sorption of the target vapor and then introduced into an IMS for more accurate detection and characterization of the vapor due to the increased sorption of the vapor by the SPME device described herein. | 04-02-2009 |
20080295783 | Controlled Odor Mimic Permeation System - The primary aspect of the Controlled Odor Mimic Permeation System (COMPS) is that it provides a field deployable instant and reproducible source of known amounts of target odors. This technology consists of a permeable polymer container (chosen to suit target odor and release rate required), stored inside a non-permeable package. The design allows for the pre-equilibration of the target odors such that the outer surface of the inner package can saturate with odor during storage. Removal of the inner item then provides an instant and reproducible source of known target vapor flux. We have successfully demonstrated this technology by placing the target odor chemicals within permeable membranes such as low density polyethylene which are then sealed within a non-permeable membranes such as metallized polyester. This design has multiple advantages including preventing cross contamination when storing multiple odor targets (5-10 targets are commonly employed) as well as being light-weight disposable, low unit cost potential, no external power/operating unit/machinery/hardware, simple to use and providing a known reproducible concentration of the target odors to the detector in the field. The applications of these COMPS include the whole range of biological (e.g. detector dog) and electronic (e.g. field sensors) detectors with examples such as explosives (e.g. 2-ethyl-1-hexanol simulating plasticized explosives), drugs (e.g. 3,4-methylenedioxybenzaldehyde simulating ecstasy), human remains (including dimethyl disulfide and pentanoic acid) and live human scent (including 5-heptene-2-one and nonanol). | 12-04-2008 |