| THE CURATORS OF THE UNIVERSITY OF MISSOURI Patent applications |
| Patent application number | Title | Published |
|---|
| 20120134918 | GUM ARABIC COATED 198GOLD RADIOACTIVE NANOPARTICLES FOR CANCER THERAPY - The invention provides a cancer therapeutic and imaging agent comprising a solution containing Gum Arabic coated | 05-31-2012 |
| 20120130421 | RATCHETING STAPLE FOR SURGICAL APPLICATIONS - A surgical staple device which accommodates various tissue thicknesses by employing unique modified surfaces with increased friction is disclosed. The staple device includes a U-shaped staple body with modified surfaces on its legs, whereas the modified surfaces may be designed as ratchet teeth, barbs, hooks, grooves, and channels. The staple device further includes a footplate to receive and engage the legs. | 05-24-2012 |
| 20120129970 | POLYMER COMPOSITES AND FABRICATIONS THEREOF - The present invention provides polymer composites reinforced with high aspect ratio reinforcing fillers selected from calcium phosphate nanofibers, nanoplates, submicron fibers, submicron plates, and combinations thereof. The mechanical and biological properties of the inventive composites are enhanced significantly over current polymer composites and may be employed in various biomedical applications, such as dental restorations. | 05-24-2012 |
| 20120094828 | HIGH SURFACE AREA CARBON AND PROCESS FOR ITS PRODUCTION - The present invention provides a high surface area porous carbon material and a process for making this material. In particular, the carbon material is derived from biomass and has large mesopore and micropore surfaces that promote improved adsorption of materials and gas storage capabilities. | 04-19-2012 |
| 20120093994 | Meat Analog Compositions and Process - Analog meat compositions produced from vegetable protein and processes for producing the analog meat compositions are described. The compositions are produced with high moisture content, low vegetable protein content, carbohydrate, and, optionally, an edible lipid material and provides a product that simulates the fibrous structure of animal meat and has a desirable meat-like moisture, texture, mouthfeel, flavor and color. | 04-19-2012 |
| 20120083907 | VARIABLE PRODUCT AGROCHEMICALS APPLICATION MANAGEMENT - Methods and products are provided for facilitating application of variable-product agrochemicals, such as fertilizer, to an application area, such as a field. The fertilizer or agrochemical may include a single fertilizer or agrochemical type or a mixture. In one embodiment, a fertilizer-application area is divided into application cells, and a fertilizer product is determined for each cell, based on zones of the application area with a similar characteristic, such as topographic wetness index levels. Based on a determined product for each cell, instructions for controlling an agrochemical applicator are automatically generated. | 04-05-2012 |
| 20120071682 | ORGANOSILICA NANOPARTICLES AND METHOD FOR MAKING - Preparation of Free-Flowing Organosilica Nanoparticles by Forming a solution of an organosilica nanoparticle precursor in a mixed solvent system comprising a first solvent and a second solvent, wherein the first solvent is different from the second solvent, wherein the second solvent has a boiling point which is greater than a boiling point of the first solvent, and wherein the nanoparticle precursor has a greater solubility in the first solvent than in the second solvent; removing at least 50% of the first solvent to form nanoparticles having a mean particle size less than about 25 nanometers dispersed in the solution; adding a coupling agent to the solution to facilitate reacting of the coupling agent with the nanoparticles; and recovering the nanoparticles from the solution, wherein the recovered nanoparticles have the mean particle size of less than about 25 nanometers | 03-22-2012 |
| 20120064566 | MULTIPLE PHASE FLOW SYSTEM FOR DETECTING AND ISOLATING SUBSTANCES - A multiple flow system and method for detecting substances in a fluid is provided. More specifically, a first fluid tube containing a first fluid and a second fluid tube containing a second fluid are coupled to a common fluid tube via a connector, such that alternating discrete compartments of the first fluid and the second fluid flow through the common fluid tube. The first and second fluids are immiscible. A substance detector, having a flow chamber with an internal wall, is coupled to the common fluid tube. The alternating discrete compartments of the first and second fluids flow through the flow chamber and are analyzed by the substance detector. | 03-15-2012 |
| 20120047588 | Methods for Conditional and Inducible Transgene Expression to Direct the Development of Embryonic, Embryonic Stem, Precursor and Induced Pluripotent Stem Cells - Methods are disclosed in which the expression of a specific gene, or combinations of genes, is controlled spatially and temporally to develop intra- and interspecies chimeras. A transgenic EC/ES/P/iPS cell line is created which conditionally expresses a suicide or compromiser gene configured to compromise all cell lineages except that corresponding to a target tissue/organ. The EC/ES/P/iPS cell line is injected into donor embryos having a specific target gene deficiency or embryos genetically engineered to be complementary compromised in lineages corresponding to the target tissue/organ cell lineages of the EC/ES/P/iPS line. One or more stimuli is provided to the embryo to activate compromiser genes for ablation of non-target tissues/organs of the EC/ES/P/iPS line and target tissues/organs of the host embryo, resulting in a chimeric animal having target tissues/organs derived from the genotype of the transgenic cell line and all remaining tissues/organs derived from the donor embryo. | 02-23-2012 |
| 20120015874 | NOVEL INHIBITORS OF RETROVIRAL REVERSE TRANSCRIPTACE - Disclosed are nucleic acid molecules, and methods of their use, which have a specific structure including a double helical domain and a G-quadruplex domain physically connected by a linker domain which may be nucleosidic or non-nucleosidic. These aptamers demonstrate potent inhibition of phylogenetically diverse primate lentiviral reverse transcriptases, which effect is largely independent of aptamer sequence provided that the aptamer has the specified structure. | 01-19-2012 |
| 20110313542 | ENGINEERED BIOLOGICAL NERVE GRAFT, FABRICATION AND APPLICATION THEREOF - An engineered three-dimensional structure includes living cells cohered with each other. The living cells suitably include Schwann cells and at least one other type of cell. The cells accompanying the Schwann cells can suitably be bone marrow stem cells or another type of cell having one or more anti-inflammatory properties. The structure is suitably a graft that facilitates restorative axon growth when the graft is implanted between the proximal and distal stubs of a severed nerve in a living organism. The graft can optionally include a plurality of acellular conduits extending between opposite axial ends of the graft. Bio-printing techniques can be used to assemble a three-dimensional construct that becomes through maturation an axon-guiding graft, by stacking a plurality of multicellular bodies, each of which includes a plurality of living cells cohered to one another to sufficiently to avoid collapsing when the multicellular bodies are stacked to form the structure. | 12-22-2011 |
| 20110313392 | STEERABLE EPIDURAL CATHETER - A steerable catheter device which can be steered to locations within the epidural space, as well as methods of use and manufacture are disclosed. The steerable catheter provides a site-specific drug delivery system for accessing the epidural space. The catheter devices includes a steerable wire or a liner extending from a proximal end of the catheter to the catheter's distal end. Forces applied to the wire or the liner cause the distal end to deflect and/or rotate to reach a targeted epidural site. | 12-22-2011 |
| 20110293840 | SYSTEMS AND METHODS FOR FABRICATING A DIRECT METAL DEPOSITION STRUCTURE HAVING FULLY FORGED STRUCTURAL QUALITIES - A method for fabricating a direct metal deposition (DMD) structure having substantially fully forged structural qualities is provided. In various embodiments, the method includes depositing a layer of metallic material onto an existing metallic structure having a microstructure that provides the existing metallic structure with substantially fully forged structural qualities. The DMD layer has a microstructure that provides the DMD layer with non-forged structural qualities. The method additionally includes applying a friction stir process to the deposited DMD layer utilizing a friction stir device such that the deposited DMD layer and at least a DMD affected zone of the existing metallic structure are friction stirred to refine and homogenize the microstructure of the deposited DMD layer and at least the DMD affected zone of the existing metallic structure, thereby producing a non-forged aggregate structure having a microstructure that provides the aggregate structure substantially fully forged structural qualities. | 12-01-2011 |
| 20110290252 | CLOSED LOOP RESPIRATORY SUPPORT DEVICE WITH DYNAMIC ADAPTABILITY - The invention provides an automatic system based on the dynamic adaptability strategy for controlling oxygen concentration in blood of patients with fluctuating oxygen needs. The inventive system monitors patient's clinical measurement data and updates the system continuously, which provides changes in FiO | 12-01-2011 |
| 20110281316 | BACILLUS BASED DELIVERY SYSTEM AND METHODS OF USE | 11-17-2011 |
| 20110277592 | SEPARATION METHOD FOR CARRIER-FREE RADIOLANTHANIDES - A method for separating a lanthanide from a mixture containing at least one other lanthanide is provided. In particular, an HPLC and liquid separation method using a chromatographic column for separating a lanthanide from a mixture containing at least one other lanthanide is provided. | 11-17-2011 |
| 20110259039 | Thermally Driven Heat Pump for Heating and Cooling - A thermally driven heat pump includes a low temperature evaporator for evaporating cooling fluid to remove heat A first heat exchanger located at an outlet of a converging/diverging chamber of a first ejector receives a flow of primary fluid vapor and cooling fluid vapor ejected from the first ejector for condensing a portion of the cooling fluid vapor An absorber located in the first heat exchanger absorbs cooling fluid vapor into an absorbing fluid to reduce the pressure in the first heat exchanger A second heat exchanger located at an outlet of a converging/diverging chamber of a second ejector receives primary fluid vapor and cooling fluid vapor ejected from the second ejector for condensing the cooling fluid vapor and the primary fluid vapor A separator in communication with the second ejector, the low temperature evaporator and the primary fluid evaporator separates the primary fluid from the cooling fluid. | 10-27-2011 |
| 20110250667 | FOSSIL FUEL-FREE PROCESS OF LIGNOCELLULOSIC PRETREATMENT WITH BIOLOGICAL HYDROGEN PRODUCTION - The invention provides an isolated haloalkaliphilic microorganism designated as strain sapolanicus belonging to the genus | 10-13-2011 |
| 20110237057 | SYSTEMS AND METHODS FOR CO-DOPING WIDE BAND GAP MATERIALS - Various embodiments of the present disclosure provide a method of simultaneously co-doping a wide band gap material with p-type and n-type impurities to create a p-n junction within the resulting wide band gap composite material. The method includes disposing a sample comprising a dopant including both p-type and n-type impurities between a pair of wide band gap material films and disposing the sample between a pair of opposing electrodes; and subjecting the sample to a preselected vacuum; and heating the sample to a preselected temperature; and applying a preselected voltage across the sample; and subjecting the sample to at least one laser beam having a preselected intensity and a preselected wavelength, such that the p-type and n-type impurities of the dopant substantially simultaneously diffuse into the wide band gap material films resulting in a wide band gap compound material comprising a p-n junction. | 09-29-2011 |
| 20110224673 | JOINT IMPLANT AND PROSTHESIS AND METHOD - Disclosed herein is a minimally invasive ball joint implant and prosthesis for the treatment of arthritis, trauma, and other medical conditions leading to joint destruction and pain, as well as methods of use. In various cases, the prosthesis does not require reaming into the intramedullary canal and does not require diaphyseal fit for any bones associated with the joint, thereby resulting in more rapid and complete recovery. In various cases, the prosthesis incorporates an anchoring stem specifically designed to be impacted into the bone and to facilitate bony ingrowth after implantation, thereby strengthening the implanted prosthesis and preventing rotation thereof. | 09-15-2011 |
| 20110223616 | HuR-Associated Biomarkers - The present invention relates to methods of identifying gene targets, including methods of using ribonucleoprotein (RNP) immunoprecipitation-microarrays to identify cancer gene targets, such as subsets of RNP-associated mRNAs in breast cancer cell lines. Also presented, are ribonucleotide binding protein-associated biomarkers, panels or sets of ribonucleotide binding protein-associated biomarkers, methods and compositions comprising ribonucleotide-binding protein, associated nucleotides, nucleotide arrays, and kits to facilitate the diagnosis of and monitoring the disease status or progression of treatment of breast cancers, including drug-resistant breast cancers. | 09-15-2011 |
| 20110218116 | BIOMARKERS OF OSTEOARTHRITIS - Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, IL6, MMP1, RANTES, MMP9, IL1B, Apolipoprotein A1, Apolipoprotein E, DCN, CILP and COMP. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described. | 09-08-2011 |
| 20110217762 | PHOTO-ACOUSTIC DETECTION DEVICE AND METHOD - An example method for detecting an analyte in a sample of a bodily fluid comprises the steps of exposing the bodily fluid sample to electromagnetic energy to cause a thermoelastic expansion in the analyte, and detecting a photoacoustic signal in the sample that results from the thermoelastic expansion. | 09-08-2011 |
| 20110213198 | HIGH-THROUGHPUT AND NON-INVASIVE METHOD TO VITRIFY PORCINE EMBRYOS - The present invention provides a practical, non-invasive, and efficient method for cryopreservation of an in-vitro-produced porcine embryo. The inventive method treats the NP (such as IVF- or NT-derived) embryo at the one-cell or cleavage stage prior to compaction with high osmolality followed by high speed centrifugation. The high osmolality treatment enlarges the periviteline space, and with centrifugation, enables the separation of the lipids from the cytoplasm. The lipid-separated embryos after high osmolality treatment have been successfully cryopreserved and later recovered and transferred to produce live offspring. | 09-01-2011 |
| 20110206077 | Thin Disk Laser Operations with Unique Thermal Management - A thermal management apparatus and method for a thin disk laser system enabling the laser system to have near isothermal temperatures across and throughout a thin disk comprising a mechanically controlled oscillating heat pipe having effective thermal conductivity of 10-20,000 W/m*K that promotes near isothermal conditions in lasing of the thin disk, a thin disk lasing crystal or ceramic bonded to the mechanically controlled oscillating heat pipe, and a supporting structure including a surface bonded to the thin disk that matches the CTE (coefficient of thermal expansion) of both materials. | 08-25-2011 |
| 20110204122 | HOLLOW STRUCTURES FORMED WITH FRICTION STIR WELDING - A hollow structure, and a method of forming the hollow structure, where the hollow structure includes first and second metal parts, the second metal part having an interior surface and a tapered support member extending from the interior surface. The hollow structure also includes a friction stir welded joint that extends through the first metal part and into the tapered support member. | 08-25-2011 |
| 20110199015 | DIAMOND COMPOSITE AS ILLUMINATION SOURCE - The present disclosure provides a new diamond composite comprising a diamond material doped with a preselected transition metal or metal compounds as an illumination source with broadband white light luminosity, high efficiency, and enhanced life span. The present disclosure also provides a new method of diffusing dopants (such as transition metal or metal compounds) into an intended material (such as a diamond material). | 08-18-2011 |
| 20110196382 | DEVICE TO ASSIST DELIVERY OF FETAL HEAD AT CESAREAN SECTION - In various cases, an obstetrical device is provided for assisting a cesarean section delivery of a neonate having a fetal presenting part well seated within the mother's pelvis. Generally, the device comprises a tubular tail having an internal lumen and a hollow head extending from a distal end of the tail and having an internal chamber fluidly connected to the lumen. The head includes at least one aperture extending through an exterior wall. The device is operable to position the head near or in contact with the fetal presenting part to provide air into an area near and/or between contact surfaces of the fetal presenting part and a vagina and/or a cervix of the mother. Providing the air will reduce or release a suction formed between the contact surfaces such that the well seated fetal presenting part can be easily separated from the vagina and/or the cervix. | 08-11-2011 |
| 20110165221 | WOUND CARE - A method for treating a wound, and a dressing for wound care management comprising a three-dimensional body of glass-based fibers comprising one or more glass-formers selected from the group consisting of P | 07-07-2011 |
| 20110165217 | SCAFFOLDS WITH TRACE ELEMENT FOR TISSUE REGENERATION IN MAMMALS - A scaffold for implantation into a mammal to facilitate vessel growth in repair, regeneration, and/or proliferation of bodily tissue, where the scaffold is based on a borate, silicate, or phosphate, glass-former and is biodegradable upon implantation in mammals. The scaffold includes one or more trace elements from the group consisting of Cu, F, Fe, Mn, Mo, Ni, Sr, and Zn which are released into the host to support vessel growth. A method involves implantation of such scaffolds. | 07-07-2011 |
| 20110147217 | METHOD AND APPARATUS FOR CANCER SCREENING - A method and apparatus for detection of pteridine levels in a biological sample using CE-LIF which is useful for early cancer screening involving fully oxidizing pteridine compounds in a sample such as a urine sample, subjecting to CE-LIF to assess compound concentration, and compare to expected levels in for healthy or cancer-bearing patients. | 06-23-2011 |
| 20110110896 | Modulating levels of RNA-binding proteins for the treatment of breast cancer - The present invention relates to methods of using RNA-binding protein modulating agents to treat of cancer, particularly patients that are susceptible to or diagnosed with estrogen receptor-negative breast cancer, such as methods of inhibiting the growth or metastasis of cancer cells comprising contacting cells with a therapeutically-effective amount of an HuR-modulating agent. The invention also relates to compositions comprising therapeutically-effective amounts of an HuR-modulating agent. | 05-12-2011 |
| 20110083493 | Liquid Chromatography Detector and Flow Controller Therefor - A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector. | 04-14-2011 |
| 20110081676 | RAPID DETECTION OF VIABLE BACTERIA SYSTEM AND METHOD - An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk capacitance value is determined for a model circuit based on the impedance dataset. After a predetermined time period, a new bulk capacitance value is determined for on another portion of the sample. The difference between the new bulk capacitance and the initial bulk capacitance value is compared to a threshold value to determine if viable bacterial is present in the sample. | 04-07-2011 |
| 20110079719 | EXTERNAL/INTERNAL OPTICAL ADAPTER WITH BIASED PHOTODIODES FOR FTIR SPECTROPHOTOMETER - A Fourier Transfer Infrared (FTIR) spectrophotometer having reduced baseline noise. The system and method include internal or external optical adapters having a moveable beamsplitter for splitting the source light beam into a reference beam and a sample beam, and may include a variable bandpass filter, variable preamplifier and reversed biased photodiodes. | 04-07-2011 |
| 20110079718 | EXTERNAL/INTERNAL OPTICAL ADAPTER FOR FTIR SPECTROPHOTOMETER - A Fourier Transfer Infrared (FTIR) spectrophotometer having reduced baseline noise. The system and method include internal or external optical adapters having a moveable beamsplitter for splitting the source light beam into a reference beam and a sample beam, and may include a variable bandpass filter, variable preamplifier and reversed biased photodiodes. | 04-07-2011 |
| 20110076705 | COMPOSITIONS AND METHODS FOR EARLY PREGNANCY DIAGNOSIS - Disclosed are antibodies and methods for detecting pregnancy in an animal. In certain aspects antibodies used binds immunologically to at least two PAGs selected from PAG4, PAG6, PAG9, PAG16, PAG17, PAG19, PAG20 and PAG21. Antibody encoding nucleic acids are also provided, as are kits, methods of use and additional antibody related compositions. | 03-31-2011 |
| 20110070451 | TRANSPARENT COMPOSITES AND LAMINATES AND METHODS FOR MAKING - An exemplary method for making a transparent composite includes steps of combining a refractive index modifier with a precursor solution to provide a modified polymer precursor solution, combining glass with the modified precursor solution, and curing the modified precursor solution to create a transparent glass reinforced polymer composite. An example refractive index modifier comprises a monofunctional compound or monofunctional monomer, a polyfunctional compound or polyfunctional monomer or polymer, which is combined with the polymer precursor solution to increase the crosslinking density of the chain in the cured modified polymer precursor solution, and thus increase the refractive index. An exemplary transparent composite comprises a glass reinforced thermosetting polymer composite layer sandwiched between glass layers. | 03-24-2011 |
| 20110014262 | CONTROLLING VESSEL GROWTH AND DIRECTIONALITY IN MAMMALS AND IMPLANTABLE MATERIAL - A method for directing vessel growth toward a blood-deficient site in a mammal comprising implanting into the mammal an assembly of at glass fibers to form a vascular bridge with a first end of the vascular bridge in contact with the blood-deficient site and a second end of the vascular bridge remote from the blood-deficient site. Over time the bridge biodegrades and promotes vascularity in the direction of the bridge. | 01-20-2011 |
| 20110014261 | SCAFFOLD FOR TISSUE REGENERATION IN MAMMALS - A three-dimensional scaffold with interconnected pores for repair of tissue comprising a scaffold body for structural support of the tissue scaffold, where the scaffold body comprises scaffold body components bonded to each other and made from component materials comprising about 40 to about 90 wt % B | 01-20-2011 |
| 20110005305 | LIQUID CHROMATOGRAPHY DETECTOR AND FLOW CONTROLLER THEREFOR - A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector. | 01-13-2011 |
| 20100331879 | Articulating Surgical Hand Tool - A surgical instrument comprising a frame, a control-effector coupled to the frame, a shaft, and an end effector in fluid communication with the control-effector is disclosed. | 12-30-2010 |
| 20100328436 | ANONYMIZED VIDEO ANALYSIS METHODS AND SYSTEMS - Methods and systems for anonymized video analysis are described. In one embodiment, a first silhouette image of a person in a living unit may be accessed. The first silhouette image may be based on a first video signal recorded by a first video camera. A second silhouette image of the person in the living unit may be accessed. The second silhouette image may be of a different view of the person than the first silhouette image. The second silhouette image may be based on a second video signal recorded by a second video camera. A three-dimensional model of the person in voxel space may be generated based on the first silhouette image, the second silhouette image, and viewing conditions of the first video camera and the second video camera. In some embodiments, information on falls, gait parameters, and other movements of the person living unit are determined. Additional methods and systems are disclosed. | 12-30-2010 |
| 20100328142 | MICROWAVE AND MILLIMETER WAVE RESONANT SENSOR HAVING PERPENDICULAR FEED, AND IMAGING SYSTEM - A switched-slot sensor for use in a sensor array for microwave and/or millimeter wave imaging. The locations of a plurality of sensors in the array define a spatial domain away from an object for detecting an electric field from the object. Each of the sensors has an out-of-plane transmission line and outputs a signal representative of the measured field and the location of the sensor. A processor decodes the signals and generates an image of the object. | 12-30-2010 |
| 20100302043 | INTEGRATED SENSOR NETWORK METHODS AND SYSTEMS - Methods and systems for an integrated sensor network are described. In one embodiment, sensor data may be accessed from a plurality of motion sensors and a bed sensor deployed in a living unit for a first time period. An activity pattern for the first time period may be identified based on at least a portion of sensor data associated with the first time period. The activity pattern may represent a physical and cognitive health condition of a person residing in the living unit. Additional sensor data may be accessed from the motion sensors and the bed sensor deployed for a second time period. A determination of whether a deviation of the activity pattern of the first time period has occurred for the second time period may be performed. An alert may be generated based on a determination that the derivation has occurred. In some embodiments, user feedback is captured on the significance of the alerts, and the alert method is customized based on this feedback. Additional methods and systems are disclosed. | 12-02-2010 |
| 20100288026 | LIQUID CHROMATOGRAPHY DETECTOR AND FLOW CONTROLLER THEREFOR - A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector | 11-18-2010 |
| 20100285518 | PHOTOACOUSTIC DETECTION OF ANALYTES IN SOLID TISSUE AND DETECTION SYSTEM - A preferred system for detecting an analyte in solid tissue, such as an intact lymph node, in vitro includes a laser arranged to generate a pulsed laser beam into solid tissue, which can be a fully intact lymph node. An acoustic sensor, and preferably at least three acoustic sensors are arranged in different positions to span a three dimensional space, such as in an X, Y and Z coordinate system, to detect photoacoustic signals generated within the lymph node. At least one computer receives signals from the acoustic sensor(s). The computer determines the presence or absence of, and preferably the position of analyte, from the signals and the timing of the signals. A preferred method for detecting an analyte in a lymph node in vitro includes exposing an extracted lymph node to a pulsed laser beam. A photoacoustic signal is sensed. The photoacoustic signal is analyzed to confirm the presence or absence of an analyte in the lymph node. Preferably, multiple photoacoustic signals are sensed from sensors that span a three dimensional space and the position of analyte is also determined. | 11-11-2010 |
| 20100278823 | TREATMENT OF TYPE 1 DIABETES BEFORE AND AFTER EXPRESSION OF PREDISPOSITION MARKERS - The present invention relates generally to the use of compounds, compositions, combinations, kits, and methods for the effective endocytic presentation of immunosuppressive factors for the down regulation of diabetogenic T cells for the treatment of type 1 diabetes. | 11-04-2010 |
| 20100266508 | STABILIZED GOLD NANOPARTICLE AND CONTRAST AGENT - A kit for providing a contrast enhancer in a mammal for contrasting during imaging of the mammal comprises functionalized gold nanoparticles configured to be directed to one or more of a target organ, tissue and lesion of the mammal. | 10-21-2010 |
| 20100252721 | OPTICAL SPECTROSCOPY DEVICE FOR NON-INVASIVE BLOOD GLUCOSE DETECTION AND ASSOCIATED METHOD OF USE - An apparatus for concentrating light and associated method of use is disclosed. This apparatus includes a first outer wall having an anterior end, a posterior end, an inner surface and an outer surface, the inner surface defining an interior portion, the interior portion having an anterior end and a posterior end, and a light source disposed within the interior portion. The first outer wall has an opening in the posterior end, the opening having an opening diameter. The interior portion has a substantially frusto-conical shape and has a cross-sectional diameter at the opening equal to the opening diameter and a second cross-sectional diameter near the anterior end that is less than the opening diameter and the inner surface is photo-reflective. The light passes through a sample through an aperture and a collector lens or a second outer wall. A transmission diffraction grating may be utilized. | 10-07-2010 |
| 20100248228 | Method for detecting DNA methylation in cancer cells - The present invention provides a detecting method of detecting malignant cells in a patient's specimen or a biological sample. Specifically, the inventive method includes the steps of extracting a genomic DNA, digesting said genomic DNA with one or multiple methylation sensitive restriction enzymes, and amplifying by PCR with one or multiple selected primers. The PCR can be performed in a conventional or a real-time platform. The inventive method can detect leukemia cells in 90% ALL patients at a sensitivity of up to 10 | 09-30-2010 |
| 20100233124 | BACILLUS BASED DELIVERY SYSTEM AND METHODS OF USE | 09-16-2010 |
| 20100225834 | ADAPTIVE LENS FOR VISION CORRECTION - An adaptive liquid crystal lens system comprising a first substrate assembly, a second substrate assembly having a continuous phase profile, and a liquid crystal layer disposed between the first and second substrate assemblies. The first substrate assembly includes a first transparent substrate, an alignment layer, and a first conductive layer. The first conductive layer is disposed on the bottom surface of the first transparent substrate and adjacent to the top surface of the alignment layer. The second substrate assembly includes a second transparent substrate, a lens having a grooved surface, and a second conductive layer. The second conductive layer is a continuous layer adjacent to the lens. The liquid crystal layer is received in the grooves of the lens, and is adjacent to the bottom surface of the alignment layer. The alignment layer causes the liquid crystal material in the liquid crystal layer to be in a homeotropic state. | 09-09-2010 |
| 20100217390 | ROTATOR CUFF BONE-TENDON ALLOGRAFT - The invention provides a biomaterial and a method of selecting a biomaterial for a rotator cuff repair procedure. The biomaterial includes a bone-tendon allograft and the use of the biomaterial in rotator cuff repairs may provide immediate bone-tendon integrity and function, which may result in lower failure rates and enhanced clinical success. | 08-26-2010 |
| 20100212331 | CRYOPRESERVATION METHOD AND DEVICE - A device and method suitable for the cryopreservation of all types of biological cells is described. In this method, an ultra-fast cooling/warming device system is used to achieve vitrification of individual cells or cell suspensions without cryoprotectant agents (CPA) or with a low concentration of CPAs (<1M), to attenuate the formation of intracellular ice crystal formation during cooling, and to minimize devitrification during subsequent warming. The device system applies oscillating heat pipe (OHP) and nanofluid techniques, and is built through microfabrication. Several devices may be networked to increase the total volume of cell samples that the cryopreservation system can process simultaneously. | 08-26-2010 |
| 20100197820 | SOY-BASED POLYOLS - The invention provides B-sides of urethane formulations, wherein the B-sides comprise both alcohol and epoxy moieties. Also provided are urethane formulations comprising the B-side of the invention, as well as A-sides comprising isocyanate molecules. | 08-05-2010 |
| 20100196938 | IMMUNOASSAY FOR VENOM DETECTION INCLUDING NONINVASIVE SAMPLE COLLECTION - Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer. | 08-05-2010 |
| 20100194239 | SYSTEM AND METHOD FOR HARVESTING ENERGY FROM ENVIRONMENTAL VIBRATIONS - Embodiments of the present invention provide a system and a method for increasing the harvested energy from a piezoelectric element exposed to environmental vibrations via a two-prong system. In a first prong, a cantilever beam is tapered and shaped so as to increase and provide an approximately uniform strain on and along the beam, thus resulting in increased voltage. In a second prong of the system and method, a voltage compensating circuit, when used with a voltage inversion circuit of the prior art, increases the harvested power by injecting current to the piezoelectric element after each voltage inversion so as to increase the voltage level. | 08-05-2010 |
| 20100190951 | SOY-BASED POLYOLS - The invention provides processes for preparing soy-based oligomeric polyols or substituted oligomeric polyols, as well as urethane bioelasteromers comprising the oligomeric polyols or substituted oligomeric polyols. | 07-29-2010 |
| 20100179667 | SCAFFOLD FOR BONE AND TISSUE REPAIR IN MAMMALS - A mammalian tissue scaffold and method for making a tissue scaffold including a rigid scaffold body of biocompatible glass fibers bonded together and in special alignment to define open channels within the scaffold to allow fluid flow into and within the scaffold. | 07-15-2010 |
| 20100176789 | HIGH FREQUENCY ANALYSIS OF A DEVICE UNDER TEST - Analyzing a device under test (“DUT”) at higher frequencies. A phase shifter varies the phase of a standing wave on a transmission line coupled to the DUT. The standing wave magnitude is sampled at each of the phase shifts and one or more DUT characteristics are determined as a function of the sampled magnitudes and phase shifts. Further aspects include a related phase shifter comprising a waveguide having a plurality of sub-resonant slots formed therein and having active elements for loading the slots to control the phase shift applied to the signal. | 07-15-2010 |
| 20100130542 | Composition Comprising a Combination of Omeprazole and Lansoprazole, and a Buffering Agent, and Methods of Using Same - The present disclosure relates to pharmaceutical compositions comprising omeprazole, lansoprazole and sodium bicarbonate. Methods of using such compositions are also provided | 05-27-2010 |
| 20100128111 | NON-DESTRUCTIVE ROTARY IMAGING - Non-destructive imaging of an object. An imaging head supported on a rotatable arm samples an electric field scattered by the object at a plurality of locations as the arm rotates about a central axis, with the locations corresponding to a defined spatial domain located remotely from the object. One or more processors execute computer-readable instructions for controlling rotation of the arm and generating a multi-dimensional profile representative of the object in the defined spatial domain based on the sampling. | 05-27-2010 |
| 20100125221 | DEVICE AND METHOD FOR DETERMINING A CAP ARRANGEMENT INDICATING COLOR DISCRIMINATION - A detector located on a positioning tray has a plurality of colored caps placed by a subject being tested. Each cap has a unique resonant circuit which is selectively energized to indicate cap position to the detector so that color discrimination of the subject may be determined. | 05-20-2010 |
| 20100115640 | Methods for Conditional and Inducible Transgene Espression to Direct the Development of Embryonic, Embryonic Stem, Precursor and Induced Pluripotent Stem Cells - Methods are disclosed in which the expression of a specific gene, or combinations of genes, is controlled spatially and temporally to develop intra- and interspecies chimeras. A transgenic EC/ES/P/iPS cell line is created which conditionally expresses a suicide or compromiser gene configured to compromise all cell lineages except that corresponding to a target tissue/organ. The EC/ES/P/iPS cell line is injected into donor embryos having a specific target gene deficiency or embryos genetically engineered to be complementary compromised in lineages corresponding to the target tissue/organ cell lineages of the EC/ES/P/iPS line. One or more stimuli is provided to the embryo to activate compromiser genes for ablation of non-target tissues/organs of the EC/ES/P/iPS line and target tissues/organs of the host embryo, resulting in a chimeric animal having target tissues/organs derived from the genotype of the transgenic cell line and all remaining tissues/organs derived from the donor embryo. | 05-06-2010 |
| 20100106233 | BIONANOCOMPOSITE FOR TISSUE REGENERATION AND SOFT TISSUE REPAIR - The present invention provides a bionanocomposite including a pre-selected decellularized tissue crosslinked with a pre-selected nanomaterial. Also provided is a process for fabricating the bionanocomposite. Additionally, applications for using the bionanocomposite as soft tissue repair materials or scaffolds for tissue engineering are described. | 04-29-2010 |
| 20100094655 | SYSTEM AND METHOD FOR LINKING A WEB-BASED RESOURCE WITH AN ELECTRONIC MEDICAL RECORD - A data processing system and method that, in some cases, include an EMR system and a web server. In some cases, the EMR system includes a plurality of electronic medical records for a plurality of patients. One or more of the electronic medical records may include a URL or HTTP Post message that defines a path to a web-based resource, such as a treatment algorithm or medical calculator. In some embodiments, the URL and/or HTTP Post message is constructed based on information in a patient's medical record. | 04-15-2010 |
| 20100094066 | GAS PHASE REACTION PROCESS FOR POLYHYDRIC COMPOUNDS - The present invention provides processes for the gas phase conversion of a polyhydric feedstock into an oxygen-containing product. The polyhydric feedstock comprises water and at least one polyhydric compound having from about four to about twelve carbon atoms and more than three hydroxyl groups. Also provided are processes for the separation of the oxygen-containing product from the reaction product mixture. | 04-15-2010 |
| 20100072414 | MICROFLUIDIC VALVE SYSTEMS AND METHODS - The present disclosure provides a microfluidic valve with a liquid-film-core to open and close one or more dispensing orifices of an ejection nozzle of a microfluidic system, such as an inkjet printhead, to prevent nozzle-clogging. The microfluidic valve employs a non-volatile liquid to control ambient air exposure at a liquid-air interface. Particularly, the microfluidic valve utilizes a microfluidic driving mechanism, such as electrowetting principles or magnetic fields, to control movement of the non-volatile liquid in order to control the ambient air exposure at a liquid-air interface. The valve comprises a non-volatile liquid-film-core, a valve housing including a valve channel and a pair of aligned openings, and a valve control subsystem, whereas the liquid-film-core is movably confined within the valve channel, and the valve control subsystem controls movements of the liquid-film-core within the valve channel to Open and Close the aligned openings. | 03-25-2010 |
| 20100068550 | HOLLOW STRUCTURES FORMED WITH FRICTION STIR WELDING - A hollow structure, and a method of forming the hollow structure, where the hollow structure includes first and second metal parts, the second metal part having an interior surface and a tapered support member extending from the interior surface. The hollow structure also includes a friction stir welded joint that extends through the first metal part and into the tapered support member. | 03-18-2010 |
| 20100055019 | CALCIUM PHOSPHATE BODIES AND A PROCESS FOR MAKING CALCIUM PHOSPHATE BODIES - Among the various aspects of the present invention is a process for making calcium phosphate bodies comprising amorphous calcium phosphate, hydroxyapatite or calcium triphosphate, the bodies themselves and the use of such bodies in any of a variety of applications. | 03-04-2010 |
| 20100041134 | SELF-ASSEMBLING MULTICELLULAR BODIES AND METHODS OF PRODUCING A THREE-DIMENSIONAL BIOLOGICAL STRUCTURE USING THE SAME - Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion. Methods of producing multicellular bodies having characteristics that facilitate assembly of the three-dimensional constructs are also provided. | 02-18-2010 |
| 20100037351 | Alteration of Phospholipase De (PLDe) or Phospholipase Da3 (PLD a3) Expression in Plants - Transgenic plants and seeds with altered expression of phospholipase Dε (PLDε) are described, i.e., plants and seeds either overexpressing or underexpressing PLDε. Methods for producing such transgenic plants and for increasing a plant's ability to capture and utilize nitrogen, increasing a plant's biomass production, increasing the yield of a plant or increasing a plant's ability to grow under hyperosmotic stress by overexpressing PLDε are also disclosed. Further disclosed are transgenic plants and seeds which overexpress phospholipase D alpha3 (PLDα3), methods for producing such transgenic plants and seeds, and methods for increasing a plant's ability to grow under hyperosmotic stress by overexpressing phospholipase D alpha3. | 02-11-2010 |
| 20100036492 | OSTEOCHONDRAL IMPLANTS, ARTHROPLASTY METHODS, DEVICES, AND SYSTEMS - Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided. | 02-11-2010 |
| 20100016583 | COMPOUNDS FOR TREATMENT OF COPPER OVERLOAD - The present invention provides compounds, pharmaceutical compositions, and methods that can be used to treat pathologies that are due to copper overload or to the presence of reactive oxygen species. | 01-21-2010 |
| 20100002229 | Light Scattering Detector - The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal. | 01-07-2010 |
| 20090305281 | NOVEL INHIBITORS OF RETROVIRAL REVERSE TRANSCRIPTACE - Disclosed are nucleic acid molecules, and methods of their use, which have a specific structure including a double helical domain and a G-quadruplex domain physically connected by a linker domain which may be nucleosidic or non-nucleosidic. These aptamers demonstrate potent inhibition of phylogenetically diverse primate lentiviral reverse transcriptases, which effect is largely independent of aptamer sequence provided that the aptamer has the specified structure. | 12-10-2009 |
| 20090292186 | Method and System for Non-Invasive Optical Blood Glucose Detection Utilizing Spectral Data Analysis - Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. A variety of techniques are disclosed for improving signal-to-noise ratio in the acquisition of spectral data and calculating attenuance of light attributable to blood in a sample. Disclosed techniques include (1) using a standard deviation operation in conjunction with the logarithm function, (2) using a normalization factor, (3) using a ratio factor, (4) accounting for the effect of temperature on various system components such as resistors, and (5) accounting for dark current in a light detector by performing a calibration. | 11-26-2009 |
| 20090277283 | ASSEMBLIES FOR USE IN EVALUATING SUBSURFACE CONTAMINATION, AND RELATED METHODS - A method is provided for determining the presence and/or concentration of at least one contaminant in a subsurface at a test site. The method generally includes inserting a sampling assembly into at least one tree at the test site, processing at least part of the sampling assembly to determine if a contaminant is present in the at least one tree, and then correlating the presence and/or concentration of the contaminant in the at least one tree to presence and/or concentration of the contaminant in the subsurface. The sampling assembly is operable to sorb at least one contaminant located within the at least one tree to at least part of the sampling assembly. The sampling assembly may include a solid phase microextraction (SPME) sampling assembly having a SPME sampling device and a support configured to help position the SPME sampling device within a tree for sampling operation. | 11-12-2009 |
| 20090269016 | ULTRA-LOW REFRACTIVE INDEX HIGH SURFACE AREA NANOPARTICULATE FILMS AND NANOPARTICLES - Nanoparticles having a mean particle size of less than about 25 nanometers and a mean pore size of less than 10 nanometers, and a mean surface area of at least 500 m | 10-29-2009 |
| 20090263647 | NANOCOMPOSITE DIELECTRIC COATINGS - The present invention describes processes for coating substrates with a nanocomposite SiCON material. In addition, the present invention describes the dielectric nanocomposite coatings. | 10-22-2009 |
| 20090247843 | Method and System for Non-Invasive Blood Glucose Detection Utilizing Spectral Data of One or More Components Other Than Glucose - A method and system for detecting glucose in a biological sample is disclosed. This includes illuminating a biological sample with a light source, collecting transmitted, transflected or reflected light from the sample with a detector, generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device, and analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device. | 10-01-2009 |
| 20090237092 | MICROWAVE AND MILLIMETER WAVE IMAGING SYSTEM - A sensor array having a plurality of modulated slots for microwave and/or millimeter wave imaging. The locations of the slots in the array define a spatial domain away from an object for detecting an electric field from the object. Each of the slots outputs a signal representative of the measured field and the location of the slot. A processor decodes the signals and generates an image of the object. | 09-24-2009 |
| 20090216498 | ELECTROMAGNETIC EMISSIONS STIMULATION AND DETECTION SYSTEM - A system and method for detecting and identifying electronic devices based on their unintended electromagnetic emissions (“UEE”) signals is presented. During device classification, UEE signals are measured from a plurality of test devices and characteristic data is obtained from the UEE signal emitted from each test device. Using the characteristic data, a threshold value and ideal pulse template can be determined for each test device and stored in a memory. An ideal stimulation signal is also determined for each test device and stored in the memory. During device detection, the ideal stimulation signal is applied to the environment in which a target device is suspected of being located. Stimulated UEE signals are measured from the target device and processed. The processed measurement data is compared to stored power threshold values and ideal pulse templates to determine if the target device is present. | 08-27-2009 |
| 20090210207 | SYSTEM AND METHOD FOR SEQUENCE VARIATION/PREDICTION AND GENETIC ENGINEERING DETECTION USING DOCUMENTED CODON/AMINO ACID MUTATION AND/OR SUBSTITUTION PATTERNS - The present invention primarily relates to protein identification and can be particularly useful for bioinformaticists employing a mass spectrometry analysis. The present invention provides systems and methods to produce virtual databases, virtual database entries, or virtual amino acid sequences that can be used to improve the identification of unknown proteins and facilitate recognizing engineered proteins and distinguishing between natural and engineered genes and proteins. The present invention uses variations, such as mutation or substitution patterns, evident in and derived from known DNA, RNA, and protein sequences to predict and generate virtual DNA, RNA, and amino acid sequences that may not be represented in the current databases but that are likely to occur in nature. Substitution patterns may be derived from either the chemical, physical, and biological patterns of mutation or the derived, observable patterns of evolutionary fixation of such mutations between or within species. These virtual sequences (or databases/datafiles of such virtual sequences) contain novel, but statistically likely sequences for use in comparing to unknown proteins (peptides) for protein identification. The use of such synthetic sequences and/or databases facilitate the recognition and distinction between naturally occurring and genetically engineered DNA, RNA, and protein sequences. | 08-20-2009 |
| 20090203625 | Phage Display Selection of Anti Fungal Peptides - A method for the identification of peptides having an affinity for the surface of fungi is provided as is a method for the identification of peptides capable of affecting the development of a fungus. Also provided are compositions containing peptides identified using the method of the present invention. In addition, isolated polynucleotides, vectors, expression cassettes and transformed cells capable of expressing peptides identified by the method of the present invention are provided. | 08-13-2009 |
| 20090196390 | RADIOISOTOPE PRODUCTION AND TREATMENT OF SOLUTION OF TARGET MATERIAL - The invention provides methods for the production of radioisotopes or for the treatment of nuclear waste. In methods of the invention, a solution of heavy water and target material including fissile material present in subcritical amounts is provided in a shielded irradiation vessel. Bremsstrahlung photons are introduced into the solution, and have an energy sufficient to generate photoneutrons by interacting with the nucleus of the deuterons present in the heavy water and the resulting photoneutrons in turn cause fission of the fissile material. The bremmssrrahlung photons can be generated with an electron beam and an x-ray converter. Devices of the invention can be small and generate radioisotopes on site, such as at medical facilities and industrial facilities. Solution can be recycled for continued use after recovery of products. | 08-06-2009 |
| 20090170149 | PHOTO-ACOUSTIC DETECTION DEVICE AND METHOD - An example system for detecting an analyte in a sample of a bodily fluid comprises a test chamber having at least one sidewall and configured to contain at least a portion of a bodily fluid sample, an excitation electromagnetic energy source configured to direct an energy source into the test chamber through the at least one sidewall and to induce a thermoelastic expansion in the one or more analytes, and a sensor configured to detect said thermoelastic expansion in the bodily fluid sample in the test chamber, the sensor configured to measure changes in optical reflectance that result from the thermoelastic expansion. | 07-02-2009 |
| 20090153800 | Light Sensitivity Meter and Uses Thereof - A text apparatus for measuring the degree of light-sensitivity of a subject, such as a subject with cataracts or migraines. The apparatus comprises a viewing shroud for positioning at least one eye of the subject in a testing position and an illumination source adapted for emitting visible light toward the at least one eye of the subject. The apparatus includes a visual monitor adapted for monitoring the fixation of the at least one eye during testing. A method of the invention exposes at least one eye of a subject to light and either subjects the eye to a continuous, level light intensity or increases the intensity of the light continuously over time. The intensity of the light when the subject experiences discomfort can be recorded. Pulse width modulation can modulate the intensity of the illumination source (e.g., an LED) over time. | 06-18-2009 |
| 20090148910 | REUSABLE PCR AMPLIFICATION SYSTEM AND METHOD - A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field. | 06-11-2009 |
| 20090148465 | MUTANTS OF THE P4 PROTEIN OF NONTYPABLE HAEMOPHILUS INFLUENZAE WITH REDUCED ENZYMATIC ACTIVITY - A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable | 06-11-2009 |
| 20090117045 | Soy or lentil stabilized gold nanoparticles and method for making same - The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from soy or lentil plant material or a reactive extract thereof of the plant material. The gold nanoparticles of the invention can be fabricated with an environmentally friendly method for making biocompatible stabilized gold nanoparticles. In methods of the invention, an aqueous solution containing gold salts is mixed with soy or lentil plant material or a reactive extract thereof. In preferred embodiment methods of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with soy or lentil plant material or a reactive extract thereof. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a robust coating derived of the soy or lentil plant material or a reactive extract thereof. | 05-07-2009 |
| 20090105738 | DEVICE FOR TRANSFECTING CELLS USING SHOCK WAVES GENERATED BY THE IGNITION OF NANOENERGETIC MATERIALS - A miniature device for generating shock waves using the energy of combustion of a nanoenergetic material and directing the shock waves into biological tissues is described. | 04-23-2009 |
| 20090069241 | Compositions and Methods for Use of Pigment Epithelial Derived Factor (PEDF) Peptide Fragments - The invention provides PEDF peptides which retain the biological activity of full-length PEDF. Fusion proteins comprising a PEDF peptide are also provided. The invention further provides a codon-optimized PEDF coding sequence and method of expressing it in bacteria. Compositions, methods of use and kits are also provided. | 03-12-2009 |
| 20090023771 | PHARMACEUTICAL COMPOSITION COMPRISING A PROTON PUMP INHIBITOR AND PROTEIN COMPONENT - The present disclosure relates to, inter alia, pharmaceutical compositions comprising a H | 01-22-2009 |
| 20090022796 | Novel Substituted Benzimidazole Dosage Forms and Method of Using Same - The present invention relates to pharmaceutical preparations comprising substituted benzimidazole proton pump inhibitors. There is provided a liquid or solid pharmaceutical composition consisting of a proton pump inhibitor, including preparations of s-omeprazole, and at least one buffering agent. Also provided is a pharmaceutical composition comprising a parietal cell activator, an anti-foaming agent, a flavoring agent and combinations thereof; a method for treating acid-related gastrointestinal disorders by administering a solid pharmaceutical composition; and a kit for the preparation of a liquid oral pharmaceutical composition. Dosage forms include: liquid, powder, tablet, capsule, effervescent powder, effervescent tablet, pellets, and granules | 01-22-2009 |
| 20090014333 | AGAROSE NANO-PLATINUM COMPOSITE - The invention relates to compositions and methods of using electrophoresis separation matrices. The invention provides nano-particle comprising separation matrices having increased conductivity at low voltage. | 01-15-2009 |
| 20090006024 | ELECTROMAGNETIC EMISSIONS STIMULATION AND DETECTION SYSTEM - A system and method for detecting and identifying electronic devices based on their unintended electromagnetic emissions (“UEE”) signals is presented. During device classification, UEE signals are measured from a plurality of test devices and characteristic data is obtained from the UEE signal emitted from each test device. Using the characteristic data, a threshold value and ideal pulse template can be determined for each test device and stored in a memory. An ideal stimulation signal is also determined for each test device and stored in the memory. During device detection, the ideal stimulation signal is applied to the environment in which a target device is suspected of being located. Stimulated UEE signals are measured from the target device and processed. The processed measurement data is compared to stored power threshold values and ideal pulse templates to determine if the target device is present. | 01-01-2009 |
| 20090004269 | Pharmaceutical Composition Comprising a Proton Pump Inhibitor and a Protein Component - The present disclosure relates to, inter alia, pharmaceutical compositions comprising a H | 01-01-2009 |
| 20080311421 | Friction stir welded structures derived from AL-RE-TM alloys - A welded structure that includes first and second metal parts derived from Al-RE-TM alloys, which are secured together at a welded joint by friction stir welding. | 12-18-2008 |
| 20080308610 | Hollow structures formed with friction stir welding - A hollow structure, and a method of forming the hollow structure, where the hollow structure includes first and second metal parts, the second metal part having an interior surface and a tapered support member extending from the interior surface. The hollow structure also includes a friction stir welded joint that extends through the first metal part and into the tapered support member. | 12-18-2008 |
| 20080308197 | Secondary processing of structures derived from AL-RE-TM alloys - A method for processing a metal part includes extruding an Al-RE-TM alloy to form an extruded part, heating the extruded part, and applying a compressive strain greater than about 50% on the heated part. | 12-18-2008 |
| 20080293161 | Detection of Carbohydrate Biomarkers - The present invention generally relates to detection of carbohydrate biomarkers in nipple aspirate fluid samples. One aspect of the invention is a method for assaying a nipple aspirate fluid for the presence of TF or Tn carbohydrate biomarker. The assay generally employs an immobilized capture agent specific for TF or Tn and can be further coupled to either direct or indirect detection of bound TF or Tn carbohydrate biomarker through the use of a labeled binding agent. | 11-27-2008 |
| 20080275158 | FOAM DESTABILIZED WATER BORNE FILM FORMING COMPOSITIONS - A film-forming composition comprising a continuous aqueous phase and a dispersed phase, including a foam destabilizing additive comprising an ester, which additive helps lower the amount of foam formed and its subsequent stability and allows for more rapid air release. | 11-06-2008 |
| 20080275091 | COMPOSITIONS AND METHODS FOR TREATING NOCTURNAL ACID BREAKTHROUGH AND OTHER RELATED DISORDERS - The present invention relates to, inter alia, pharmaceutical compositions comprising an acid labile proton pump inhibitor and a buffering agent; to methods for manufacture of such compositions, and to use of such compositions in treating and preventing diseases and/or disorders. | 11-06-2008 |
| 20080268492 | Methods for Determining Optimal Techniques for Vitrification of Isolated Cells - A method to optimize a vitrification procedure for suspended cells uses factors such as the physical properties of solutions, the cell permeability to water and permeable cryoprotectants, and the osmotic tolerance of the cells to identify a method to minimize several stresses associated with vitrification procedures. | 10-30-2008 |
| 20080255674 | FEMORAL HEAD AND METHOD OF MANUFACTURE THEREOF - A femoral head made from a ceramic-metal composite having a multi-layered construction and related method of manufacture is disclosed. The femoral head includes an inner metal core bonded to a relatively thin ceramic outer layer that is used as the articulating surface with an acetabular cup during total hip arthoplasty. In another embodiment, an interface layer having a ceramic and metal mixture may be laminated between the inner metal core and the exterior ceramic layer. | 10-16-2008 |
| 20080207442 | HIGH SURFACE AREA CARBON AND PROCESS FOR ITS PRODUCTION - The present invention provides a high surface area porous carbon material and a process for making this material. In particular, the carbon material is derived from biomass and has large mesopore and micropore surfaces that promote improved adsorption of materials and gas storage capabilities. | 08-28-2008 |
