| The Children's Mercy Hospital Patent applications |
| Patent application number | Title | Published |
|---|
| 20120116794 | MEDICAL ADVICE CARD HAVING AUDIO RECORDING - The present invention is related to a medical advice card and label containing an embedded audio chip or card. The embedded audio chip or card plays information related to a health care treatment plan in order to improve compliance with physician instructions. The medical advice card or label may also contain written information relating to the audible information related to a health care treatment plan. | 05-10-2012 |
| 20120085277 | PEDIATRIC WEIGHT ESTIMATE DEVICE AND METHOD - The present invention is directed towards a device, method of using a device, and a method of making a device for predicting weight and/or the appropriate dose of a medication and/or degree of some other medical intervention in a child. The device includes one or more strips for taking a girth and a length measurement from an individual. The method includes adding or otherwise combining a value given by a girth measurement and a value given by a length measurement together to estimate the weight of the individual. | 04-12-2012 |
| 20110189667 | METHOD OF SCREENING FOR NOVEL EXON 1 MUTATIONS IN MECP2 ASSOCIATED WITH CLASSICAL RETT SYNDROME - Recently, a new MECP2 isoform, which has an alternative N-terminus, transcribed from exon 1, was described. Since the incorporation of exon 1 into standard sequencing protocol for Rett syndrome, few patients with exon 1 mutations have been described and several groups have concluded that exon 1 mutations are a rare cause of Rett syndrome. The present invention provides an improved method of diagnosing Rett Syndrome by identifying two different mutations in exon 1 of the MECP2 gene, the first of which results in a switch from alanine to valine at the beginning of a polyalanine stretch, and the second of which results in a disruption of the ATG initiation codon of exon 1. Patients having either such mutation fit the clinical criteria for classic Rett syndrome, and further support previous reports that exon 1 mutations may be associated with a severe phenotype. | 08-04-2011 |
| 20110184463 | SLIDING ROD SYSTEM FOR CORRECTING SPINAL DEFORMITIES - A sliding rod system ( | 07-28-2011 |
| 20110183904 | METHODS AND COMPOSITIONS FOR ALTERING BEHAVIOR ASSOCIATED WITH AUTISM SPECTRUM DISORDER - The present invention discloses methods for the diagnosis and treatment of autism. The diagnostic tools provided use analysis of levels of G-protein expression, oxytocin, and vasopressin. Treatment for autism spectrum disorder and symptoms of autism spectrum disorder, especially repetitive behavior, is also provided. | 07-28-2011 |
| 20110165676 | METHOD FOR DECELLULARIZATION - The present invention provides for decellularized tissue and method for decellularizing tissue. The method generally comprises the steps of obtaining a harvested tissue, performing a muscle shelf debridement, treating the tissue with an enzyme, washing the tissue with a detergent, and performing an organic solvent extraction on the tissue. The tissues decellularized according to the present invention have several advantages including removing more of the residual cell debris, dsDNA, and chemicals, as well as exhibiting less calcification and better ultimate tensile strength than tissues prepared not according to the method of the present invention. | 07-07-2011 |
| 20110112020 | MEASUREMENT OF G-PROTEIN mRNA IN THE DIAGNOSIS OF GROWTH HORMONE INSUFFICIENCY - The present invention is directed towards a diagnostic test, treatment, and monitoring of treatment for growth hormone abnormalities including Growth Hormone Deficiency (“GHD”) as well as a kit comprising the necessary components of the present invention. G-protein expression and levels of mRNA are evaluated to determine if a patient has GHD or if treatment for GHD is effective. A G-protein agonist or antagonist is used to treat GHD by bringing G-protein expression and levels of mRNA into the normal range. | 05-12-2011 |
| 20110077165 | MITIGATION OF Cot-1 DNA DISTORTION IN NUCLEIC ACID HYBRIDIZATION - A novel method of suppressing non-specific cross-hybridization between repetitive elements present in nucleic acid probes and corresponding repetitive elements in the target nucleic acid by using DNA synthesized to contain a plurality of repetitive elements while avoiding low and single copy sequences. | 03-31-2011 |
| 20110014609 | NUCLEIC ACID SIGNAL ENHANCEMENT USING NANOPARTICLE-BASED HYBRIDIZATION - A method of enhancing signal detection through use of nanoparticle-conjugated nucleic acid probes is provided. Following chromosomal FISH hybridization of a target sequence with a genomic probe linked to a flag sequence, the flag sequence is hybridized to an anti-flag sequence conjugated to a nanoparticle. The enhanced fluorescent probe is then visualized using microscopy. | 01-20-2011 |
| 20100222877 | Tissue Engineered Human Pulmonary Valves with Cyclic Pressure Bioreactor Accelerated Seeding Strategies and Methods For Assessing Inflammatory Potential of Putative Scaffolds for Tissue Engineered Heart Valves - The invention provides for bioengineered or tissue engineered heart valves that are more efficiently recellularized and/or have a decreased inflammatory potential. The heart valves are generally decellularized and then recellularized using autologous cells wherein the valves are subjected to pulsatile motion during the recellularization process. Tissue engineered heart valves subjected to the pulsatile motion are characterized by having at least 20% of the cells that remain on or in said previously decellularized tissue two weeks after the recellularization process are located below or interior to the basement membrane of said tissue. A method of making bioengineered tissues having these characteristic is also disclosed. Further provided is a bio-assay and related method for determining the inflammatory potential of a tissue. | 09-02-2010 |
| 20100042120 | TISSUE RETAINING SYSTEM - A tissue retaining system having a pair of tissue retainers for retaining two end portions of tubular tissue, such as a heart valve, to a bioreactor is disclosed. Each tissue retainer includes a stepped portion that permits custom fitting of the tissue retainer to a particular size of tubular tissue. The tissue retainer further includes a tubular portion in communication with the stepped portion that provides a means for engaging the tissue retainer to the bioreactor through a tubular connector. The stepped portion of each tissue retainer defines a plurality of progressively larger concentric steps in which one of the concentric steps matches the size of a particular tubular tissue being engaged. The tubular tissue is then anchored to the tissue retainer by suture pull downs that anchor the tubular tissue to one of the concentric steps of the tissue retainer in a fluid tight engagement. A clamp may also be engaged to the tubular tissue to further secure the tubular tissue to the tissue retainer in a fluid tight engagement. This engagement process is repeated to secure the other end portion of the tubular tissue to another tissue retainer such that the tissue retaining system may then be engaged to the bioreactor. | 02-18-2010 |
| 20100035344 | SOLUTIONS FOR TISSUE ENGINEERING AND METHODS OF USE - The present invention provides for solutions and methods of preparing a decellularized tissue for recellularization. The solutions provide collagen conditioning to restore collagen triple helix structure, strengthening of the collagen structure of the tissue, and biologically preparing the decellularized tissue by placing it in an environment that promotes recellularization. Methods and solutions for recellularization of a decellularized tissue, in accordance with the present invention, are also provided. | 02-11-2010 |
| 20100003684 | SINGLE COPY GENOMIC HYBRIDIZATION PROBES AND METHODS OF GENERATING SAME - Nucleic acid (e.g., DNA) hybridization probes are described which comprise a labeled, single copy nucleic acid which hybridizes to a deduced single copy sequence interval in target nucleic acid of known sequence. The probes, which are essentially free of repetitive sequences, can be used in hybridization analyses without adding repetitive sequence-blocking nucleic acids. This allows rapid and accurate detection of chromosomal abnormalities. The probes are preferably designed by first determining the sequence of at least one single copy interval in a target nucleic acid sequence, and developing corresponding hybridization probes which hybridize to at least a part of the deduced single copy sequence. In practice, the sequences of the target and of known genomic repetitive sequence representatives are compared in order to deduce locations of the single copy sequence intervals. The single copy probes can be developed by any variety of methods, such as PCR amplification, restriction or exonuclease digestion of purified genomic fragments, or direct synthesis of DNA sequences. This is followed by labeling of the probes and hybridization to a target sequence. | 01-07-2010 |
| 20090312533 | SINGLE COPY GENOMIC HYBRIDIZATION PROBES AND METHOD OF GENERATING SAME - Nucleic acid (e.g., DNA) hybridization probes are described which comprise a labeled, single copy nucleic acid which hybridizes to a deduced single copy sequence interval in target nucleic acid of known sequence. The probes, which are essentially free of repetitive sequences, can be used in hybridization analyses without adding repetitive sequence-blocking nucleic acids. This allows rapid and accurate detection of chromosomal abnormalities. The probes are preferably designed by first determining the sequence of at least one single copy interval in a target nucleic acid sequence, and developing corresponding hybridization probes which hybridize to at least a part of the deduced single copy sequence. In practice, the sequences of the target and of known genomic repetitive sequence representatives are compared in order to deduce locations of the single copy sequence intervals. The single copy probes can be developed by any variety of methods, such as PCR amplification, restriction or exonuclease digestion of purified genomic fragments, or direct synthesis of DNA sequences. This is followed by labeling of the probes and hybridization to a target sequence. | 12-17-2009 |
| 20080300922 | Electronic medical documentation - A system for electronic medical documentation receives a patient identifier and patient healthcare information from a user, associates the patient healthcare information with the patient identifier, and stores the patient healthcare information in an intermediate database. The system receives a command from the user and, upon receipt of the command, communicates the patient healthcare information from the intermediate database to an electronic medical record database according to a protocol that enables the electronic medical record database to store the patient healthcare information as a caregiver note in an electronic medical record pertaining to the patient identifier. The intermediate database may include patient information received from the electronic medical record database and relating only to current patients, and may be stored on a wireless handheld computing device. | 12-04-2008 |
| 20080274558 | METHOD FOR IDENTIFYING AND SELECTING LOW COPY NUCLEIC SEGMENTS - The present invention relates to a method of identifying low copy nucleic acid segments from within a known nucleic acid sequence and selecting among the identified low copy segments for segments that are thermodynamically suitable for use in hybridization experiments. | 11-06-2008 |
