| The Charles Stark Draper Laboratory, Inc. Patent applications |
| Patent application number | Title | Published |
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| 20120127029 | CODED FILTER - A method and apparatus for estimating and compensating for a broad class of non-Gaussian sensor and process noise. In one example, a coded filter combines a dynamic state estimator (for example, a Kalman filter) and a non-linear estimator to provide approximations of the non-Gaussian process and sensor noise associated with a dynamic system. These approximations are used by the dynamic state estimator to correct sensor measurements or to alter the dynamic model governing evolution of the system state. Examples of coded filters leverage compressive sensing techniques in combination with error models based on concepts of compressibility and the application of efficient convex optimization processes. | 05-24-2012 |
| 20120118811 | SYSTEMS, METHODS AND DEVICES RELATING TO A CELLULARIZED NEPHRON UNIT - The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them. | 05-17-2012 |
| 20120082393 | ATTITUDE ESTIMATION WITH COMPRESSIVE SAMPLING OF STARFIELD DATA - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
| 20120082345 | ATTITUDE ESTIMATION IN COMPRESSED DOMAIN - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
| 20120082338 | ATTITUDE ESTIMATION BY REDUCING NOISE WITH DRAGBACK - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
| 20120071792 | PHYSIOLOGICAL AND BEHAVIORAL SENSORS AND METHODS - In various embodiments, a physiological or behavioral signal is derived from a vertical force resulting from the entire weight of a subject. | 03-22-2012 |
| 20120068801 | FLUIDIC CONSTRUCTS FOR ELECTRONIC DEVICES - In various embodiments, an inductance of an inductor is tuned by adjusting a position of a conductor and/or a magnetic material with respect to a conducting wire of the inductor, thereby changing the electro-magnetic characteristics of the conducting wire. The conductor and/or magnetic material can be disposed in a microfluidic channel and can be moved within the microfluidic channel using a suitable actuator mechanism. | 03-22-2012 |
| 20120065518 | SYSTEMS AND METHODS FOR MULTILAYER IMAGING AND RETINAL INJURY ANALYSIS - Systems and methods are provided for imaging an eye and identifying retinal or subretinal features that may be indicative of pathologies such as macular degeneration and traumatic brain injury. An infrared or near-infrared image of an eye is interdependently smoothed and segmented and attributes of the image are determined. The attributes are indicative of retinal or subretinal features. | 03-15-2012 |
| 20110206262 | IMAGE-BASED METHODS FOR MEASURING GLOBAL NUCLEAR PATTERNS AS EPIGENETIC MARKERS OF CELL DIFFERENTIATION - The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell colonies, individual cells, and/or cellular structures. | 08-25-2011 |
| 20110189770 | Endosome-Disrupting Compositions and Conjugates - The present invention is directed to an endosome-disrupting conjugate, and methods of delivery of said conjugate to cells. The conjugates of the invention comprise a payload and an endosome-disrupting component of which the latter comprises a plurality of moieties that react under acidic conditions, e.g., within an endosome, to release gaseous endosome-disrupting molecules, e.g., CO | 08-04-2011 |
| 20110188728 | METHODS OF GENERATING TROPHECTODERM AND NEURECTODERM FROM HUMAN EMBRYONIC STEM CELLS - Methods for inducing differentiation of stem cells into trophectoderm, neurectoderm, or progeny cells thereof are described, and mathematical and statistical image analysis methods and systems, for example, to identify differentiated cells and screen for agents which modulate differentiation are provided for separate or combined use. | 08-04-2011 |
| 20110132088 | FLEXURE ASSEMBLIES AND METHODS FOR MANUFACTURING AND USING THE SAME - In one embodiment, an accelerometer includes a suspension frame, a proof mass, and a plurality of flexures suspending the proof mass from the suspension frame. The flexures allow the proof mass to deflect in response to an acceleration along a sensitive axis of the accelerometer. Each flexure exhibits an initial spring rate along the sensitive axis of substantially zero. | 06-09-2011 |
| 20110110577 | MATHEMATICAL IMAGE ANALYSIS BASED CELL REPROGRAMMING WITH APPLICATIONS FOR EPIGENETIC AND NON-EPIGENETIC BASE INDUCED PLURIPOTENT STEM CELL DERIVATION - Mathematical and statistical image analysis methods and systems are applied to enhance and refine the process of reprogramming cells, for example, to modify cells from patients into custom-matched stem cells. | 05-12-2011 |
| 20110102801 | DETERMINING AND COMPENSATING FOR MODULATOR DYNAMICS IN INTERFEROMETRIC FIBER-OPTIC GYROSCOPES - Determining linear modulator dynamics in an interferometric fiber-optic gyroscope may be accomplished by applying a stimulus at a point within the gyroscope, observing a response in an output of the gyroscope, and determining, from the observed response, the linear modulator dynamics. | 05-05-2011 |
| 20110082563 | MICROSCALE MULTIPLE-FLUID-STREAM BIOREACTOR FOR CELL CULTURE - Microfluidic bioreactor devices may feature intercommunicating microchannels defined in two polymer layers separated by a membrane. A geometric parameter associated with the microchannels in one layer may vary along a length of those channels. | 04-07-2011 |
| 20110047776 | METHODS AND APPARATUS FOR MOUNTING A CRYSTAL - In various embodiments, a crystal is inserted within a flexible membrane through an opening formed by manipulation of the membrane. | 03-03-2011 |
| 20110024346 | SYSTEMS, METHODS AND DEVICES RELATING TO A CELLULARIZED NEPHRON UNIT - The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them. | 02-03-2011 |
| 20100250031 | PROPULSIVE GUIDANCE FOR ATMOSPHERIC SKIP ENTRY TRAJECTORIES - The invention set forth herein describes propulsive guidance methods and apparatus for controlling and shaping an atmospheric skip reentry trajectory for a space vehicle. Embodiments of the invention may utilize a powered explicit guidance algorithm to provide a closed-loop control method for controlling a space vehicle during a skip reentry maneuver. | 09-30-2010 |
| 20100221188 | Coated sensors and methods related thereto - The invention provides coated sensors for detecting the presence of analytes. The sensor comprises one or more fluorescent sources, such as one or more quantum dots or one or more fluorescent dyes, a polymeric matrix, a surface coating, and one or more analyte sensing components. The surface coating may be a conformal polymeric film, permeable to the analyte, which may be deposited via a solventless process such as initiated chemical vapor deposition or photoinitiated chemical vapor deposition. The surface coating may increase the biocompatibility of the sensor, reduce nonspecific protein adsorption, and/or sequester functional sensor components within the sensor. The invention also provides methods for detecting the presence of an analyte with coated sensors of the invention. | 09-02-2010 |
| 20100116657 | METHOD AND APPARATUS FOR CONCENTRATING MOLECULES - A method and apparatus for continuously separating or concentrating molecules that includes flowing two fluids in laminar flow through an electrical field and capturing at one of three outputs a fluid stream having a different concentration of molecules. | 05-13-2010 |
| 20100105075 | SYSTEMS AND METHODS OF VOLTAGE-GATED ION CHANNEL ASSAYS - Systems and methods are provided for optically measuring ion concentrations in biological samples. The systems and methods employ polymer-based optical ion sensors that include ion-selective ionophores and a pH sensitive chromionophore. Electrodes are providing for electrically stimulating the biological samples. | 04-29-2010 |
| 20100067085 | SYSTEMS, METHODS AND DEVICES FOR ACTUATING A MOVEABLE MINIATURE PLATFORM - Presented herein are systems, methods and devices relating to miniature actuatable platform systems. According to one embodiment, the systems, methods, and devices relate to controllably actuated miniature platform assemblies including a miniature mirror. | 03-18-2010 |
| 20100002929 | Image-based methods for measuring global nuclear patterns as epigenetic markers of cell differentiation - The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell colonies, individual cells, and/or cellular structures. | 01-07-2010 |
| 20090317233 | ROTARY NANOTUBE BEARING STRUCTURE AND METHODS FOR MANUFACTURING AND USING THE SAME - In one embodiment, a rotary device includes a multiwall nanotube that extends substantially perpendicularly from a substrate. A rotor may be coupled to an outer wall of the multiwall nanotube, be spaced apart from the substrate, and be free to rotate around an elongate axis of the multiwall nanotube. | 12-24-2009 |
| 20090259885 | Systems and methods for redundancy management in fault tolerant computing - Systems and methods for redundancy management in fault tolerant computing are provided. The systems and methods generally relate to enabling the use of non-custom, off-the-shelf components and tools to provide redundant fault tolerant computing. The various embodiments described herein, generally speaking, use a decrementer register in a general purpose processor for synchronizing identical operations across redundant general purpose processors, execute redundancy management services in the kernels of commercial off-the-shelf real-time operating systems (RTOS) running on the general purpose processors, and use soft coded tables to schedule operations and assign redundancy management parameters across the general purpose processors. | 10-15-2009 |
| 20090201510 | DETERMINING AND COMPENSATING FOR MODULATOR DYNAMICS IN INTERFEROMETRIC FIBER-OPTIC GYROSCOPES - Determining linear modulator dynamics in an interferometric fiber-optic gyroscope may be accomplished by applying a stimulus at a point within the gyroscope, observing a response in an output of the gyroscope, and determining, from the observed response, the linear modulator dynamics. | 08-13-2009 |
| 20090155183 | Sensors for the detection of diols and carbohydrates - The systems and methods disclosed herein include a sensor particle for detecting the presence of a chelatable analyte, such as glucose, wherein the sensor comprises a chromophore and a fluorescent component, such as a quantum dot. The sensor particle further comprises moieties that bind both a clelatable analyte and chromophore reversibly and competitively. In the presence of the chelatable analyte, the moieties bind the analyte, and release the chromophore. The chromophore absorbs photons of one wavelength in a free state but of a different wavelength in a bound state, and is selected to operate with the fluorescent component such that the chromophore absorbs emissions of the fluorescent substance in only one of the bound and unbound states. In certain aspects, the invention comprises methods for detecting the presence of a chelatable analyte in a medium such as water, blood plasma and urine, using the sensor particles of the invention. | 06-18-2009 |
| 20090142274 | Intracellular nanosensors and methods for their introduction into cells - The invention provides ion-selective sensors capable of selectively measuring ions, e.g., Na | 06-04-2009 |
| 20080237044 | Method and apparatus for concentrating molecules - A method and apparatus for continuously separating or concentrating molecules that includes flowing two fluids in laminar flow through an electrical field and capturing at one of three outputs a fluid stream having a different concentration of molecules. | 10-02-2008 |
