| THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS Patent applications |
| Patent application number | Title | Published |
|---|
| 20120137287 | OPTIMIZED GAME SERVER RELOCATION ENVIRONMENT - A system is provided for migrating a VM over a WAN. A first server has a VM. The first and second servers are operatively connected over the WAN by a virtual private local area network service. The first server migrates the VM to the second server by coping files and state of the VM to the second server without interrupting the interactive software on the VM. During a last round of migrating the VM, for packets intended for the VM on the first server, the first server buffers the packets in a buffer as buffered packets. Instead of delivering the buffered packets to the VM, the first server transmits the buffered packets to the second server. The second server plays the buffered packets to the VM migrated to and operating on the second server, such that buffered packets are played before current packets currently received from the clients are played. | 05-31-2012 |
| 20120135474 | HEMICELLULOSE-DEGRADING ENZYMES - The present disclosure provides methods for the conversion of hemicellulose into fermentable sugars using enzymes isolated from | 05-31-2012 |
| 20120129179 | SCN5A SPLICING FACTORS AND SPLICE VARIANTS FOR USE IN DIAGNOSTIC AND PROGNOSTIC METHODS - Provided herein are methods of identifying a subject at risk for arrhythmias, heart failure or sudden cardiac death. In exemplary aspects, the method comprises the step of determining a level of splicing factor hLuc7a, splicing factor RBM25 and/or PERK in a biological sample obtained from the subject, wherein an increased level, compared to a control level, indicates a risk for arrhythmia or heart failure. The invention also provides methods of diagnosing hypertrophic cardiomyopathy (HCM), or a risk therefor, in a subject. The method comprises the step of determining a level of E28D, RBM25, PRPF40A, or LUC7L3, or a combination thereof, in a biological sample obtained from the subject, wherein an increased level is indicative of the subject having HCM or a risk therefor. Diagnostic kits comprising binding agents for the markers are furthermore provided. | 05-24-2012 |
| 20120116739 | Infrared Microspectroscopy for Intact Fibers - Methods and a non-transient computer medium embodying computer readable code for extracting bulk spectroscopic properties of a particle. A forward model is built of an optical field focused on, and interacting with, the particle, where the forward model parameterized in terms of at least one geometrical characteristic of the particle. The particle, which may be a filamentary material, is illuminated with an incident optical field having a spectral range. Either a transmitted or scattered optical field is detected in a far-field zone as a function of wavenumber to obtain a measured spectrum. The measured spectrum is inverted to recover the imaginary part of the complex refractive index of the particle. | 05-10-2012 |
| 20120115128 | SELECTIVE PROTEIN LABELING - The present invention is related to methods of detecting protein-protein interactions in living cells, as well as detecting the formation and/or inhibition of protein-protein interactions in cells. | 05-10-2012 |
| 20120108570 | Pharmacological Treatment for Sleep Apnea - The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity. | 05-03-2012 |
| 20120105858 | Spatial Light Interference Microscopy and Fourier Transform Light Scattering for Cell and Tissue Characterization - Methods and apparatus for rendering quantitative phase maps across and through transparent samples. A broadband source is employed in conjunction with an objective, Fourier optics, and a programmable two-dimensional phase modulator to obtain amplitude and phase information in an image plane. Methods, referred to as Fourier transform light scattering (FTLS), measure the angular scattering spectrum of the sample. FTLS combines optical microscopy and light scattering for studying inhomogeneous and dynamic media. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. Full angular information, limited only by the microscope objective, is obtained from extremely weak scatterers, such as a single micron-sized particle. A flow cytometer may employ FTLS sorting. | 05-03-2012 |
| 20120104554 | FLEXIBLE AND ON WAFER HYBRID PLASMA-SEMICONDUCTOR TRANSISTORS - Preferred embodiment flexible and on wafer hybrid plasma semiconductor devices have at least one active solid state semiconductor region; and a plasma generated in proximity to the active solid state semiconductor region(s). Doped solid state semiconductor regions are in a thin flexible solid state substrate, and a flexible non conducting material defining a microcavity adjacent the semiconductor regions. The flexible non conducting material is bonded to the thin flexible solid state substrate, and at least one electrode is arranged with respect to said flexible substrate to generate a plasma in said microcavity, where the plasma will influence or perform a semiconducting function in cooperation with said solid state semiconductor regions. A preferred on-wafer device is formed on a single side of a silicon on insulator wafer and defines the collector (plasma cavity), emitter and base regions on a common side, which provides a simplified and easy to manufacture structure. A preferred embodiment array of flexible hybrid plasma transistors of the invention is an n+pn PBJT fabricated between two flexible sheets. One or both of the flexible sheets is transparent. The overall array structure is planar, and the planarized structure is sealed between the two flexible sheets. Visible or ultraviolet light is emitted during operation by plasma collectors in the array. In preferred embodiments, individual PBJTs in the array serve as sub-pixels of a full-color display. | 05-03-2012 |
| 20120101770 | FALL DETECTION - A fall detection device may be uniquely associated with a wearer. The fall detection device may predict whether a fall event is imminent based on kinematic information of the wearer's body. The device may also confirm whether the wearer actually experienced a fall event based on additional kinematic information. | 04-26-2012 |
| 20120100446 | Hydrogen Storage Using Hydrocarbon Nanostructures and Sonication - Hydrogen storage materials and methods of reversibly storing and generating hydrogen using sonication and hydrocarbon nanostructures are described. | 04-26-2012 |
| 20120098029 | PHOTONICALLY-ACTIVATED SINGLE-BIASFAST-SWITCHING INTEGRATED THYRISTOR - Preferred embodiments of the invention include a thyristor core that is single biased by a source, such as a power source (or a portion thereof) that is being switched through the thyristors. An optically activated transistor that is preferably a minority carrier device is in series with the thyristor core. The thyristor core has an optically activated gate. The turn-off of the thyristor can be accelerated by the turn-on (conduction state) of a gate switch, which ensures a unity gain turn-off of the core thyristor. | 04-26-2012 |
| 20120091800 | System and Method for Optimizing Solar Power Conversion - A solar power system is provided for maximizing solar power conversion. The solar power system includes n power units connected in series and n-1 DC-DC converting units, and each of the n-1 DC-DC converting units is coupled to at least one of n solar power units. Each of the n-1 DC-DC converting units is configured to control the correspondingly connected solar power units to operate at a target current generation. The solar power system further includes a controlling unit coupled to the n-1 DC-DC converting units. The controlling unit monitors and compares the n currents generated by the n solar power units. Based on the current comparison, the controlling unit determines a series current and controls the n solar power units so that each of the generated photovoltaic currents is substantially equal to the determined series current. | 04-19-2012 |
| 20120090825 | NANOFIBER COVERED MICRO COMPONENTS AND METHODS FOR MICRO COMPONENT COOLING - A device including a micro component having an external surface and a permeable nanofiber covering on at least a portion of the external surface of the micro component. A cooled micro component system further includes a droplet spray system for spraying liquid droplets onto the nanofiber covering to cool the micro component. In an example method for cooling a micro component, droplet spray is directed onto a nanofiber covering that covers at least a portion of the micro component. The directing is controlled to permit efficient spreading and evaporation of liquid permeating the nanofiber covering. In example embodiments nanofibers of the permeable nanofiber covering are metalized to provide a rougher surface (e.g., a nano-textured metal layer). | 04-19-2012 |
| 20120083099 | Printable Semiconductor Structures and Related Methods of Making and Assembling - The present invention provides a high yield pathway for the fabrication, transfer and assembly of high quality printable semiconductor elements having selected physical dimensions, shapes, compositions and spatial orientations. The compositions and methods of the present invention provide high precision registered transfer and integration of arrays of microsized and/or nanosized semiconductor structures onto substrates, including large area substrates and/or flexible substrates. In addition, the present invention provides methods of making printable semiconductor elements from low cost bulk materials, such as bulk silicon wafers, and smart-materials processing strategies that enable a versatile and commercially attractive printing-based fabrication platform for making a broad range of functional semiconductor devices. | 04-05-2012 |
| 20120074830 | ENCAPSULATED METAL MICROTIP MICROPLASMA DEVICES, ARRAYS AND FABRICATION METHODS - An embodiment of the invention is a microtip microplasma device having a first metal microtip opposing a second metal microtip with a gap therebetween. The first and second metal microtips are encapsulated in metal oxide that electrically isolates and physically connects the first and second metal microtips. In preferred devices, the first and second metal microtips and metal oxide comprise a monolithic, unitary structure. Arrays can be flexible, can be arranged in stacks, and can be formed into cylinders, for example, for gas and liquid processing devices, air filters and other applications. A preferred method of to forming an array of microtip microplasma devices provides a metal mesh with an array of micro openings therein. Electrode areas of the metal mesh are masked leaving planned connecting metal oxide areas of the metal mesh unmasked. Planned connecting metal oxide areas are electrochemically etched to convert the planned connecting metal oxide areas to metal oxide that encapsulates opposing metal microtips therein. The mask is removed. The electrode areas are electrochemically etched to encapsulate the electrode areas in metal oxide. | 03-29-2012 |
| 20120071580 | Suturable Hybrid Superporous Hydrogel Keratoprosthesis for Cornea - The present invention features a hybrid superporous hydrogel scaffold for cornea regeneration and a method for producing the same. The hybrid hydrogel is composed of a superporous poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) copolymer mixed with collagen. The hybrid scaffold can be used as a suturable hybrid corneal implant or keratoprosthesis. | 03-22-2012 |
| 20120069324 | HIGH RESOLUTION LARGE DISPLACEMENT/CRACK SENSOR - A structural displacement sensor that includes an arched member having two ends, where each end is attached to a fastening member. In an embodiment of the invention, the fastening members are configured to be attached to a structure. Further, a strain gauge is attached to the arched member, and the strain gauge is operatively connected to a signal processing device. In an embodiment, the arched member and strain gauge are configured to measure a displacement of the structure based on the amount of strain detected on the strain gauge. | 03-22-2012 |
| 20120067615 | Materials and Methods for Autonomous Restoration of Electrical Conductivity - An autonomic conductivity restoration system includes a solid conductor and a plurality of particles. The particles include a conductive fluid, a plurality of conductive microparticles, and/or a conductive material forming agent. The solid conductor has a first end, a second end, and a first conductivity between the first and second ends. When a crack forms between the first and second ends of the conductor, the contents of at least a portion of the particles are released into the crack. The cracked conductor and the released contents of the particles form a restored conductor having a second conductivity, which may be at least 90% of the first conductivity. | 03-22-2012 |
| 20120063184 | Zero-Voltage-Switching Scheme for High-Frequency Converter - Method for operating an ac/ac converter circuit for a high-frequency-link converter. The ac/ac converter circuit converts an ac input voltage to an ac output voltage. When the ac input voltage is zero, each of a pair of switches for both first and second arms are caused to be on. Current flows through the first arm along a first direction and through the second arm along a second, opposite direction. Next, when the ac input voltage is zero, a selected switch in the second arm is caused to be turned off. The position of the switches can be maintained as the ac input voltage transitions to a dc level, reaches the dc level, approaches zero, and again reaches zero. When the ac input voltage again reaches zero, the selected switch for the second arm is caused to be turned on. | 03-15-2012 |
| 20120059184 | System for Controlling the Reactivity of Boronic Acids - A protected organoboronic acid includes a boron having an sp | 03-08-2012 |
| 20120058292 | Vacuum Insulation Panel - A vacuum insulation panel (VIP) in an example comprises first and second walls and a plurality of tensile elements. The first and second walls are structurally coupled to allow formation of a vacuum cavity between the first and second walls. The plurality of tensile elements structurally supports the first and second walls against external pressure contemporaneous with tension on the plurality of tensile elements. The plurality of tensile elements is located in the vacuum cavity between the first and second walls. | 03-08-2012 |
| 20120045763 | Antibodies Against Cells of Fetal Origin - This invention relates to antibodies that specific bind to fetal CD36+ cells in preference to binding to maternal CD36+ cells and methods for using these antibodies to detect and separate fetal cells from adult biological fluids including maternal peripheral blood. | 02-23-2012 |
| 20120040995 | DESIGN, SYNTHESIS AND EVALUATION OF PROCASPASE ACTIVATING COMPOUNDS AS PERSONALIZED ANTI-CANCER DRUGS - Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed that have lower neurotoxicity effects than other compounds. | 02-16-2012 |
| 20120039353 | Particle Dynamics Microscopy using Temperature Jump and Probe Anticorrelation/Correlation Techniques - An apparatus and methods for characterizing the response of a particle to a parameter that characterizes an environment of the particle. A change is induced in the parameter characterizing the environment of the particle, where the change is rapid on a timescale characterizing kinetic response of the particle. The response of the particle is then imaged at a plurality of instants over the course of a period of time shorter than the timescale characterizing the kinetic response of the particle. The response may be detected by measuring a temperature jump or by measuring correlation and anticorrelation between probe parameters across pixels. More particularly, the particle may be a molecule, such as a biomolecule, and the environment, more particularly, may be a biological cell. The parameter characterizing the environment of the particle may be a temperature, and change may be induced in the temperature by heating a volume that includes the particle, either conductively or radiatively. The volume may be heated by means of a laser, such as an infrared laser, for example, or by microwave heating. | 02-16-2012 |
| 20120027167 | METHOD AND APPARATUS FOR VETERINARY CT SCANS - A substantially X-ray transparent animal restraint enclosure having an open base structure and a lid which is configured to substantially close the base structure. The lid is movable from a closed position to an open position to permit the introduction of an animal into the base structure. The base structure has an open-ended slot which is partially obstructed when the lid is closed. The base structure also has an aperture which is not obstructed by the lid. A veterinary CT scan apparatus includes a CT scan gantry or sensor ring, a CT scan table, and a substantially X-ray transparent animal restraint enclosure. A method of performing a CT scan on an animal in a CT scan apparatus having a patient target position is achieved by placing the animal in substantially X-ray transparent enclosure; placing the enclosure in the patient target position for the CT scan; and conducting the CT scan. | 02-02-2012 |
| 20120025826 | Method For Reducing Artifacts In Magnetic Resonance Imaging - Disclosed are methods for magnetic resonance imaging (MRI) that reduce the appearance of fast spin echo cups artifacts using a slice-titting gradient. In particular, the excited image slice is titted relative to the image slice selected by the refocusing RF pulse. | 02-02-2012 |
| 20120022024 | ANTI-BACTERIAL COMPOSITIONS AND METHODS INCLUDING TARGETING VIRULENCE FACTORS OF STAPHYLOCOCCUS AUREUS - This disclosure relates to compositions and methods including for the inhibition, prevention, and/or treatment of microbial infections, including infections from such pathogens as | 01-26-2012 |
| 20120018021 | VORTEX GENERATORS TO CONTROL BOUNDARY LAYER INTERACTIONS - Devices for generating streamwise vorticity in a boundary includes various forms of vortex generators. One form of a split-ramp vortex generator includes a first ramp element and a second ramp element with front ends and back ends, ramp surfaces extending between the front ends and the back ends, and vertical surfaces extending between the front ends and the back ends adjacent the ramp surfaces. A flow channel is between the first ramp element and the second ramp element. The back ends of the ramp elements have a height greater than a height of the front ends, and the front ends of the ramp elements have a width greater than a width of the back ends. | 01-26-2012 |
| 20120010198 | Methods for Treating Sleep Disorders by Cholecystokinin (CCK) Receptor B Antagonists - The present invention relates to a method for preventing or ameliorating a sleep-related breathing disorder. The method involves the use of one or a combination of cholecystokinin (CCK) receptor antagonists. | 01-12-2012 |
| 20120000770 | ELECTROCHEMICAL DEPOSITION PLATFORM FOR NANOSTRUCTURE FABRICATION - Probe-based methods are provided for formation of one or more nano-sized or micro-sized elongated structures such as wires or tubes. The structures extend at least partially upwards from the surface of a substrate, and may extend fully upward from the substrate surface. The structures are formed via a localized electrodeposition technique. The electrodeposition technique of the invention can also be used to make modified scanning probe microscopy probes having an elongated nanostructure at the tip or conductive nanoprobes. Apparatus suitable for use with the electrodeposition technique are also provided. | 01-05-2012 |
| 20110320878 | Parametric Trace Slicing - A program trace is obtained and events of the program trace are traversed. For each event identified in traversing the program trace, a trace slice of which the identified event is a part is identified based on the parameter instance of the identified event. For each trace slice of which the identified event is a part, the identified event is added to an end of a record of the trace slice. These parametric trace slices can be used in a variety of different manners, such as for monitoring, mining, and predicting. | 12-29-2011 |
| 20110317157 | APPARATUS AND METHOD FOR IN SITU TESTING OF MICROSCALE AND NANOSCALE SAMPLES - According to example embodiments of the invention, a microscale testing stage comprises a frame having first and second opposing ends and first and second side beams, at least one deformable force sensor beam, a first longitudinal beam having a free end, a second longitudinal beam having a facing free end, a support structure, and a pair of slots disposed at each of the free ends. In certain embodiments, a separately fabricated microscale or nanoscale specimen comprises a central gauge length portion of a material to be tested, and first and second hinges providing a self-aligning mechanism for uniaxial loading. In other embodiments, a layer of a conductive material defines first and second conductive paths and an open circuit that can be closed by the specimen across the gap. In other embodiments, the stage is formed of a high melting temperature material. | 12-29-2011 |
| 20110316120 | Release Strategies for Making Transferable Semiconductor Structures, Devices and Device Components - Provided are methods for making a device or device component by providing a multilayer structure having a plurality of functional layers and a plurality of release layers and releasing the functional layers from the multilayer structure by separating one or more of the release layers to generate a plurality of transferable structures. The transferable structures are printed onto a device substrate or device component supported by a device substrate. The methods and systems provide means for making high-quality and low-cost photovoltaic devices, transferable semiconductor structures, (opto-)electronic devices and device components. | 12-29-2011 |
| 20110315575 | Methods, Compositions and Articles of Manufacture for Contributing to the Treatment of Cancers - Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ET | 12-29-2011 |
| 20110311481 | Methods and Compositions for Contributing to the Treatment of Cancers - Methods and compositions for contributing to the treatment of cancers, especially ovarian tumors, are disclosed. The methods and compositions utilize an endothelin B agonist (ET | 12-22-2011 |
| 20110294835 | Muscarinic Agonists as Cognitive Enhancers - A method of treating a mental condition in a subject in need thereof, comprising: administering to a subject in need thereof an effective amount of compound CDD-102A. | 12-01-2011 |
| 20110294166 | THERMOSTABLE ENZYMES FOR THE HYDROLYSIS OF MANNAN-CONTAINING POLYSACCHARIDES - The present disclosure relates to hydrolysis of mannan-containing poly- or oligo-saccharides by use of a polypeptide having endo-β-mannanase activity. In particular the present disclosure relates to compositions comprising a bacterial endo-β-mannanase, polynucleotides encoding the endo-β-mannanase, and methods of use thereof. | 12-01-2011 |
| 20110287092 | COMPOSITIONS COMPRISING DECITABINE AND TETRAHYDROURIDINE AND USES THEREOF - Compositions comprising decitabine and tetrahydrouridine for the treatment of blood disorders and hematological and solid malignancies are described. | 11-24-2011 |
| 20110281353 | Composition and Method for Facilitating the Internalization of a Therapeutic Agent into a Cell - The present invention is a composition and method for facilitating the internalization of a therapeutic agent into a cell. Specifically, the invention relates to the use of the extracellular domain of basigin-2, cyclophilin, or anti-basigin-2 antibody or antibody fragment as a delivery moiety for internalization of a therape. | 11-17-2011 |
| 20110277177 | Soybean Genes for Resistance to Aphis Glycines - resistance (RAG) genes are provided by this invention, along with methods for identifying their presence using marker-assisted selection. Varieties of | 11-10-2011 |
| 20110275788 | FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS - The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation. | 11-10-2011 |
| 20110275272 | METHOD FOR MAKING BURIED CIRCUMFERENTIAL ELECTRODE MICROCAVITY PLASMA DEVICE ARRAYS, AND ELECTRICAL INTERCONNECTS - In a preferred method of formation embodiment, a metal foil or film is obtained or formed with micro-holes. The foil is anodized to form metal oxide. One or more self-patterned metal electrodes are automatically formed and buried in the metal oxide created by the anodization process. The electrodes form in a closed circumference around each microcavity in a plane(s) transverse to the microcavity axis, and can be electrically isolated or connected. Preferred embodiments provide inexpensive microplasma device electrode structures and a fabrication method for realizing microplasma arrays that are lightweight and scalable to large areas. Electrodes buried in metal oxide and complex patterns of electrodes can also be formed without reference to microplasma devices—that is, for general electrical circuitry. | 11-10-2011 |
| 20110274566 | MAGNETICALLY DRIVEN MICROPUMP - A magnetically driven micropump for handling small fluid volumes. The micropump includes a first chamber and a second chamber. A flexible membrane being disposed between the first and second chambers. The flexible membrane being magnetically coupled to an actuator for displacing the membrane. | 11-10-2011 |
| 20110269834 | COMPOUNDS AND METHODS FOR TREATING RESPIRATORY DISEASES - Described herein are compounds and compositions, and methods for using the compounds and compositions, for treating respiratory diseases and illness, such as severe acute respiratory syndrome (SARS). | 11-03-2011 |
| 20110267617 | Second-Order Nonlinear Susceptibility of a Nanoparticle Using Coherent Confocal Microscopy - A coherent confocal microscope and methods for measuring elements of the non-linear susceptibility of a nanoparticle, including, more particularly, all of the elements of the second-order susceptibility tensor of a single nanoparticle under permutation and Kleinman symmetry. Using a high numerical aperture lens, two-dimensional scanning and a vector beam shaper, the second-order nonlinear susceptibility is derived from a single confocal image. A forward model for the problem is presented and a computationally efficient data processing method robustly solves the inverse problem. | 11-03-2011 |
| 20110263880 | EFFICIENT METHOD FOR PREPARING 2,5-DIMETHYLFURAN - The present disclosure provides methods to make liquid fuels from renewable, carbon neutral precursors. Specifically, methods to prepare 2,5-dimethylfuran from a source of fructose or other carbohydrates using a one-pot synthesis are provided. In some embodiments, the disclosed methods avoid the isolation of intermediates, and employ “green” reagents like formic acid and acetic acid. | 10-27-2011 |
| 20110260609 | INTERWOVEN WIRE MESH MICROCAVITY PLASMA ARRAYS - Embodiments of the invention provide for large arrays of microcavity plasma devices that can be made inexpensively, and can produce large area but thin displays or lighting sources Interwoven metal wire mesh, such as interwoven Al mesh, consists of two sets of wires which are interwoven in such a way that the two wire sets cross each other, typically at πght angles (90 degrees) although other patterns are also available Fabrication is accomplished with a simple and inexpensive wet chemical etching process The wires in each set are spaced from one another such that the finished mesh forms an array of openings that can be, for example, square, rectangular or diamond-shaped The size of the openings or microcavities is a function of the diameter of the wires in the mesh and the spacing between the wires in the mesh used to form the array of microcavity plasma devices. | 10-27-2011 |
| 20110257398 | Compositions and Methods Including Cell Death Inducers and Procaspase Activation - Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3. | 10-20-2011 |
| 20110257145 | METHOD OF TREATING NEUROLOGICAL DISEASES - A method of treating neurological diseases, like Alzheimer's Disease by administering a compound that activates protein kinase C and inhibits histone deacetylases to an individual suffering from the neurological disease. The method utilizes benzolactam compounds that reduce Aβ production and blocks oxidative stress in the treatment of Alzheimer's disease. The benzolactam compounds and compositions containing the benzolactam compounds also are disclosed. | 10-20-2011 |
| 20110256213 | PHOSPHOLIPID MICELLAR AND LIPOSOMAL COMPOSITIONS AND USES THEREOF - The invention generally relates to compositions and methods for the reduction or neutralization of toxins associated with a bacterial, mycobacterial, fungal, viral, or protozoal agent. More particularly, the invention is directed to sterically stabilized phospholipid micellar and liposomal compositions, which interact with the toxins to decrease or neutralize their toxicity. Additionally, the invention includes the use of sterically stabilized phospholipid micellar compositions comprising one or more water-insoluble antibiotic, antifungal, antiviral, antiprotozoal, or anti-inflammatory agent(s), wherein the micellar or liposomal composition inhibits the formation of aggregates. The invention further includes the use of sterically stabilized micelle and liposomal compositions to deliver compounds to the site of action, and in some cases targets the compound to the site of action, for the treatment of inflammation and infection. The invention includes the use of combinations of such micellar and liposomal compositions to improve the effectiveness of treatment. | 10-20-2011 |
| 20110252930 | HARD TURNING MICRO-MACHINE TOOL - A micro-scale apparatus for supporting a tool for hard turning comprises a base, a pivot coupled to the base, an actuator coupled to the base, and at least one member coupled to the actuator at one end and rotatably coupled to the pivot at another end. A tool mount is disposed on the at least one member. The at least one member defines a first lever arm between the pivot and the tool mount, and a second lever arm between the pivot and the actuator. The first lever arm has a length that is less than a length of the second lever arm. The actuator moves the tool mount along an arc. | 10-20-2011 |
| 20110237448 | CARBOHYDRATE BINDING MODULE WITH AFFINITY FOR INSOLUBLE XYLAN - The present disclosure relates to isolated polynucleotides with two polynucleotide sequences linked within one open reading frame, in which the first polynucleotide sequence encodes a peptide that binds to a carbohydrate. The present disclosure also relates to vectors and genetically modified host cells containing such isolated polynucleotides and polypeptides encoded by such isolated polynucleotides. The present disclosure further relates to methods of increasing the ability of a recombinant protein to bind to a carbohydrate and methods of identifying a protein having an ability to bind to a carbohydrate. | 09-29-2011 |
| 20110236956 | MULTICISTRONIC siRNA CONSTRUCTS TO INHIBIT TUMORS - Multicistronic short interfering RNA constructs targeting in various combinations a human urokinase-type plasminogen activator receptor (uPAR), human urokinase-type plasminogen activator (uPA), human matrix metalloprotease 9 (MMP-9) and cathepsin B (CB) inhibit tumors. | 09-29-2011 |
| 20110229909 | RHO1-Gamma Amino Butyric Acid C Receptor-Specific Antibodies - This invention provides antibodies immunologically specific for ρ1-GABA | 09-22-2011 |
| 20110220890 | Methods and Devices for Fabricating and Assembling Printable Semiconductor Elements - The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations. | 09-15-2011 |
| 20110207741 | Activation of the Renin-Angiotensin System (RAS) and Sudden Cardiac Death - Provided herein are methods of treating a medical condition in which RAS activation is increased. The method comprises the step of administering to a subject a c-Src inhibitor in an amount effective to treat the medical condition. The invention also provides a method of treating or preventing a cardiac arrhythmia. The method comprises the step of administering to the subject a c-Src inhibitor in an amount effective to treat or prevent the cardiac arrhythmia. The invention additionally provides a method of delaying the onset of sudden cardiac death. The method comprises the step of administering to the subject a c-Src inhibitor in an amount effective to delay the onset of SCD. Methods of augmenting gap junction function and methods of increasing Connexin 43 levels in a subject in need thereof are further provided. | 08-25-2011 |
| 20110201542 | Myeloid Protein Activation of Anti-Inflammatory and Anti-Hypoxic Pathway - Provided are methods to enhance healing of wounds and tissue, especially during or pursuant to psychological and/or physical stress and to protect tissue from deleterious effects associated with oxidative, psychological and/or physical stress, including but not limited to extreme exertion, ischemia, infarct, and damage associated with reperfusion of ischemic or transplanted tissues. | 08-18-2011 |
| 20110178799 | METHODS AND SYSTEMS FOR IDENTIFYING SPEECH SOUNDS USING MULTI-DIMENSIONAL ANALYSIS - Methods and systems of identifying speech sound features within a speech sound are provided. The sound features may be identified using a multi-dimensional analysis that analyzes the time, frequency, and intensity at which a feature occurs within a speech sound, and the contribution of the feature to the sound. Information about sound features may be used to enhance spoken speech sounds to improve recognizability of the speech sounds by a listener. | 07-21-2011 |
| 20110178016 | PULSE PARATHYROID HORMONE FOR TREATMENT OF THE HEMATOPOIETIC SYNDROME, STROMAL CELL LOSS, AND VASCULAR INJURY RESULTING FROM ACUTE EXPOSURE TO LETHAL RADIATION - Currently there is no treatment for hematopoietic syndrome following radiation exposure. Exposed persons are presently treated with blood transfusions, growth factors such as G-CSF to promote neutrophil recovery. Present methods are targeted towards the bone marrow microenvironment, aiding in repair and regeneration with a decrease in the severity or possibly, complete avoidance of morbidity and mortality associated with the hematopoietic syndrome. Methods are useful for treatment of mass casualties following a radiation disaster. | 07-21-2011 |
| 20110177118 | Non-Simian Cells for Growth of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus - Disclosed are compositions and methods relating to growth of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) using non-simian cells. In a particular example, porcine alveolar macrophage cells are described as having a capability of supporting infectivity and reproduction by PRRSV. Cells and cell lines of the invention are disclosed in connection with applications relating to PRRS disease, including vaccine technologies. | 07-21-2011 |
| 20110171813 | Release Strategies for Making Transferable Semiconductor Structures, Devices and Device Components - Provided are methods for making a device or device component by providing a multilayer structure having a plurality of functional layers and a plurality of release layers and releasing the functional layers from the multilayer structure by separating one or more of the release layers to generate a plurality of transferable structures. The transferable structures are printed onto a device substrate or device component supported by a device substrate. The methods and systems provide means for making high-quality and low-cost photovoltaic devices, transferable semiconductor structures, (opto-)electronic devices and device components. | 07-14-2011 |
| 20110171225 | Novel Plasmodium Falciparum Gene Encoding Signal Peptide Peptidase and Method of Using Inhibitors Thereof for Inhibiting Malarial Infection - This invention provides reagents, methods and pharmaceutical compositions for treating and preventing malaria. Specifically, the invention provides methods for inhibiting a | 07-14-2011 |
| 20110171193 | COMPOSITIONS AND METHODS FOR TREATING PULMONARY HYPERTENSION - Provided herein are methods and materials for treating pulmonary hypertension (PH) in a subject. Also provided herein is a method of diagnosing whether a has PH by detecting a PH marker. A PKG pulmonary hypertension marker has been identified and may be useful in predicting PH disease progression and assessing a subject's response to PH therapy. | 07-14-2011 |
| 20110167115 | TIE STRENGTH PREDICTION AND SOCIAL MEDIA FILTRATION - A computer-implemented method of predicting tie strength between persons within a social media network includes: modeling tie strengths between a user of the social media network and connected persons in the network as a combination of: a plurality of predictive variables, interactions between dimensions of the predictive variables, and network structure of the social media network; altering or filtering a stream of social media content from the connected persons using the tie strength as associated with the respective connected persons according to the modeling; and delivering the altered or filtered stream of social media content to a communications device of the user. | 07-07-2011 |
| 20110165631 | ARABINITOL DEHYDROGENASE FROM NEUROSPORA CRASSA - Stable and active arabinitol dehydrogenases (LAD) from | 07-07-2011 |
| 20110154527 | Soybean Gene for Resistance to Aphis Glycines | 06-23-2011 |
| 20110152221 | PAK1 Agonists and Methods of Use - The present invention is directed to Pak1 agonists and methods of use. | 06-23-2011 |
| 20110148282 | VARIABLE ELECTRIC FIELD STRENGTH METAL AND METAL OXIDE MICROPLASMA LAMPS AND FABRICATION - Preferred embodiments of the invention provide microcavity plasma lamps having a plurality of metal and metal oxide layers defining a plurality of arrays of microcavities and encapsulated thin metal electrodes. Packaging encloses the plurality of metal and metal oxide layers in plasma medium. The metal and metal oxide layers are configured and arranged to vary the electric field strength and total gas pressure (E/p) in the lamp. The invention also provides methods of manufacturing a microcavity plasma lamp that simultaneously evacuate the volume within the packaging and a volume surrounding the packaging to maintain an insignificant or zero pressure differential across the packaging. The packaging is backfilled with a plasma medium while also maintaining an insignificant or zero pressure differential across the packaging. | 06-23-2011 |
| 20110144192 | Method for modulating or controlling sodium channel current by reactive oxygen species (ROS) originating from mitochondria - Method for modulating or controlling sodium channel current of a cell includes inducing mitochondrial reactive oxygen species (ROS) production in the cell. | 06-16-2011 |
| 20110143998 | IDENTIFICATION AND USE OF PEPTIDE INHIBITORS OF PROTEIN SYNTHESIS - The present invention discloses compositions of peptide inhibitors of protein synthesis, and methods of identifying peptide inhibitors that are capable of inhibiting protein synthesis through an interaction at a stem-loop H18 in 16S rRNA of a 30S ribosomal subunit. Screening methods for peptides are disclosed, in addition to methods of determining the affinity of a test compound for a ribosomal subunit. | 06-16-2011 |
| 20110142884 | Materials and Methods for Making Improved Micelle Compositions - Provided are methods of treatment of many different diseases and disorders using micelle and sterically stabilized crystalline compounds of the invention. | 06-16-2011 |
| 20110142808 | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells - Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/or a buffer. Processes of preparing the solutions and suspensions are also disclosed. The solutions and suspensions may be employed in methods of isolating mammalian cells, such as pancreatic islets, methods of preserving mammalian tissue and organs, methods of aiding the recovery of mammalian cells following their isolation, methods of maintaining mammalian cells, methods of propagating mammalian cells, and methods of treating a mammal with diabetes. | 06-16-2011 |
| 20110140073 | SEMICONDUCTING MICROCAVITY AND MICROCHANNEL PLASMA DEVICES - Preferred embodiments of the invention provide semiconducting microcavity plasma devices. Preferred embodiments of the invention are microcavity plasma devices having at least two pn junctions, separated by a microcavity or microchannel and powered by alternate half-cycles of a time-varying voltage waveform. Alternate embodiments have a single pn junction. Microplasma is produced throughout the cavity between single or multiple pn junctions and a dielectric layer isolates the microplasma from the single or multiple pn junctions. Additional preferred embodiments are devices in which the spatial extent of the plasma itself or the n or p regions associated with a pn junction are altered by a third (control) electrode. | 06-16-2011 |
| 20110132031 | GAS PURIFICATION SYSTEM AND METHOD FOR LIQUEFACTION OF DILUTE GAS COMPONENTS - The invention provides gas purification methods and systems for the recovery and liquefaction of low boiling point organic and inorganic gases, such as methane, propane, CO | 06-09-2011 |
| 20110130652 | APPARATUS FOR BIOMEDICAL IMAGING - A system that incorporates teachings of the present disclosure may include, for example, a method involving capturing spectral interference from an optical coherence tomography imaging probe comprising a micro-electro-mechanical system (MEMS) scanning mirror, and a partial reflector for supplying images to an image sensor. Additional embodiments are disclosed. | 06-02-2011 |
| 20110129742 | Nonequilibrium Chemovoltaic Fuel Cell - A chemovoltaic cell converts chemical energy generated by an in-situ molecular hydrogen oxidation reaction into electrical energy by creating a chemically induced nonequilibrium electron population on a catalytic surface of a Schottky structure, followed by charge separation and electric power generation using the Schottky contact. | 06-02-2011 |
| 20110117627 | REGULATION OF APOPTOSIS BY NEURAL SPECIFIC SPLICE VARIANTS OF IG20 - Pro-apoptotic signaling caused by down-modulation of KIAA0358 or expression of IG20-SV4 effectively induces spontaneous apoptosis and sensitization to TNFα-induced apoptosis in neuroblastoma cells. Methods and composition to enhance cell death in neuroblastoma are provided. Methods and compositions to reduce cell death in neurodegenerative disorders are provided. | 05-19-2011 |
| 20110115886 | SYSTEM FOR EXECUTING 3D PROPAGATION FOR DEPTH IMAGE-BASED RENDERING - A system is disclosed for executing depth image-based rendering of a 3D image by a computer having a processor and that is coupled with one or more color cameras and at least one depth camera. The color cameras and the depth camera are positionable at different arbitrary locations relative to a scene to be rendered. In some examples, the depth camera is a low resolution camera and the color cameras are high resolution. The processor is programmed to propagate depth information from the depth camera to an image plane of each color camera to produce a propagated depth image at each respective color camera, to enhance the propagated depth image at each color camera with the color and propagated depth information thereof to produce corresponding enhanced depth images, and to render a complete, viewable image from one or more enhanced depth images from the color cameras. The processor may be a graphics processing unit. | 05-19-2011 |
| 20110112447 | PORTABLE ACTIVE FLUID POWERED ANKLE-FOOT ORTHOSIS - A portable active pneumatically-powered ankle foot orthosis. A lower leg mount and a foot bed are pivotally coupled at or proximate to an ankle position. A pneumatically powered rotary actuator is configured to receive power from a wearable fluid power source and provide controlled force and resistance to aid or inhibit relative rotation of the foot bed and the lower leg mount. Embedded sensors provide feedback from the device. | 05-12-2011 |
| 20110109224 | MICROCAVITY PLASMA DEVICES WITH NON-UNIFORM CROSS-SECTION MICROCAVITIES - An embodiment of the invention IS an array of microcavity plasma devices The array includes a first metal film electrode with a plurality of non-uniform cross-section microcavities therein that are encapsulated in oxide A second electrode is a thin metal foil encapsulated in oxide that is bonded to the first electrode A packaging layer contains gas or vapor in the non-uniform cross-section microcavities To make such device, photoresist is patterned to encapsulate the anodized foil or film except on a top surface at desired positions of microcavities A second anodization or electrochemical etching is conducted to form the non-uniform cross-section sidewall microcavities cavities After removing photoresist and metal oxide, a final anodization lines the walls of the microcavities with metal oxide and fully encapsulates the metal electrodes with metal oxide | 05-12-2011 |
| 20110098780 | APPARATUS FOR MANAGING A NEUROLOGICAL DISORDER - A system that incorporates teachings of the present disclosure may include, for example, a Neuro Sensing and Stimulation Device having a conductive lead for implanting in a brain of a living entity, a sensor coupled to the conductive lead for collecting data associated with one or more electrical signals detected in the conductive lead, a stimulator coupled to the conductive lead to apply one or more electrical signals thereto, and a controller. The controller can be operable to collect data associated with one or more electrical signals detected in the conductive lead, determine a stimulation sequence from the collected data, and direct the stimulator to apply on the conductive lead one or more electrical signals determined from the stimulation sequence. Additional embodiments are disclosed. | 04-28-2011 |
| 20110092568 | MODULATION OF MLCK-L EXPRESSION AND USES THEREOF - In various aspects and embodiments the invention provides methods and reagents for controlling gene expression, and for treating disorders and diseases. Embodiments provide methods and reagents specifically for the regulation of MLCK expression and for the use thereof in treating disorders and diseases. Various embodiments provide methods and reagents for specifically down regulating the expression of MLCK-L more efficiently than that of MLCK-S, and for the use thereof in treating disorders and diseases. Embodiments provide siNA for the same, particularly siRNAs. Various of the embodiments are useful for the treatment of inflammatory disorders and diseases, including, for one example in the regard, Asthma. | 04-21-2011 |
| 20110092440 | METHOD OF REGULATING CELL GROWTH USING A PROTEASOME INHIBITOR - This invention provides methods and pharmaceutical compositions for regulating cell growth or inducing apoptosis in a cell, particularly a mammalian tumor cell. Specifically, the invention provides methods for inducing apoptosis in a tumor cell comprising contacting the tumor cell with a proteasome inhibitor and a thiazole antibiotic, particularly each in a suboptimal amount. | 04-21-2011 |
| 20110086845 | Compositions and Methods for Treating Neurodegenerating Diseases - This invention provides agents, compositions, pharmaceutical compositions and methods for treating or slowing the progression of a neurodegenerating disease, such as Alzheimer's disease and a demyelinating disease. | 04-14-2011 |
| 20110078834 | Temperature-Dependent Nanoscale Contact Potential Measurement Technique and Device - The present invention provides a microcantilever capable of independently measuring and/or controlling the electrical potential and/or temperature of a surface with nanometer scale position resolution. The present invention also provides methods of manipulating, imaging, and/or mapping a surface or the properties of a surface with a microcantilever. The microcantilevers of the present invention are also capable of independently measuring and/or controlling the electrical potential and/or temperature of a gas or liquid. The devices and methods of the present invention are useful for applications including gas, liquid, and surface sensing, micro- and nano-fabrication, imaging and mapping of surface contours or surface properties. | 03-31-2011 |
| 20110065650 | Methods of Inhibiting Tumor Cell Proliferation - The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal. | 03-17-2011 |
| 20110063718 | Optical frequency up-conversion of femtosecond pulses into targeted single bands in the visible and ultraviolet - An apparatus and methods for generating a substantially supercontinuum-free widely-tunable multimilliwatt source of radiation characterized by a narrowband line profile. The apparatus and methods employ nonlinear optical mechanisms in a nonlinear photonic crystal fiber (PCF) by detuning the wavelength of a pump laser to a significant extent relative to the zero-dispersion wavelength (ZDW) of the PCF. Optical phenomena employed for the selective up-conversion in the PCF include, but are not limited to, four-wave mixing and Cherenkov radiation. Tunability is achieved by varying pump wavelength and power and by substituting different types of PCFs characterized by specified dispersion properties. | 03-17-2011 |
| 20110046074 | HIGHLY PERMEABLE POLYMERIC MEMBRANES - Provided are substantially flat membranes that include a block or graft co-polymer and a water transport protein, such as Aquaporin-Z, or a synthetic mimic of such proteins. Also provided are methods of removing contaminants from a liquid, by contacting the liquid with a substantially flat membrane that includes a block or graft co-polymer and a water transport protein or synthetic mimic thereof. Also provided are methods of making such membranes. Further provided are compositions that include at least one active ingredient and vesicles surrounding the active ingredient, where the vesicles include a block or graft copolymer and a water transport protein or synthetic mimic surrounding the active ingredient. Also provided are methods that include administering such compositions to patients. | 02-24-2011 |
| 20110041058 | SYSTEM FOR CYBER INVESTIGATION AND DATA MANAGEMENT - A system for executing a cyber investigation by a non-expert user, including a computer having a processor, a memory, and a display; a computer-readable medium having stored thereon instructions for execution of a wizard application, the processor adapted to execute the instructions when the computer-readable medium is inserted into the computer, the processor programmed to: receive case information; receive a type of activity being investigated in response to user inputs to select the activity type from a list of possible activity types; guide the user through capturing data related to the selected activity type through steps presented to the user through one or more screens shown in the display, the steps presented such that a non-expert user can follow them; receive user inputs through a screens to obtain information needed to continue capturing the data related to the selected activity; and store the captured data in a removable data storage device or medium for analysis and use in the cyber investigation. | 02-17-2011 |
| 20110037102 | HYBRID PLASMA-SEMICONDUCTOR OPTOELECTRONIC DEVICES AND TRANSISTORS - The invention provides combination semiconductor and plasma devices, including transistors and phototransistors. A preferred embodiment hybrid plasma semiconductor device has active solid state semiconductor regions; and a plasma generated in proximity to the active solid state semiconductor regions. Devices of the invention are referred to as hybrid plasma-semiconductor devices, in which a plasma, preferably a microplasma, cooperates with conventional solid state semiconductor device regions to influence or perform a semiconducting function, such as that provided by a transistor. The invention provides a family of hybrid plasma electronic/photonic devices having properties previously unavailable. In transistor devices of the invention, a low temperature, glow discharge is integral to the hybrid transistor. Example preferred devices include hybrid BJT and MOSFET devices. | 02-17-2011 |
| 20110020910 | METHODS AND COMPOSITIONS FOR IMPROVING SUGAR TRANSPORT, MIXED SUGAR FERMENTATION, AND PRODUCTION OF BIOFUELS - The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell, methods of increasing transport of a pentose into a cell, methods of increasing growth of a cell on a medium containing pentose sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell. | 01-27-2011 |
| 20110015397 | Selective Aliphatic C-H Oxidation - A composition including a complex of a metal, a tetradentate ligand, at least one ancillary ligand, and a counterion may be used for selective sp | 01-20-2011 |
| 20110008311 | Animal Model and Use of 17Beta-Hydroxysteroid Dehydrogenase Type 7 in the Diagnosis of Anencephaly - The present invention features a non-human animal in which is deficient in the expression of endogenous 17β Hydroxysteroid Dehydrogenases Type 7 and use of the same in screening methods for agents that prevent or treat anencephaly. The present invention also provides a method for diagnosing and treating. | 01-13-2011 |
| 20100331445 | Systems For Self-Healing Composite Materials - A composite material precursor composition includes a matrix precursor, a first plurality of capsules including a liquid polymerizer, an activator, and an accelerant. The liquid polymerizer polymerizes when in contact with the activator, and the accelerant is an accelerant for the polymerization of the liquid polymerizer. The composite material precursor may be used to form a composite material that includes a solid polymer matrix, the first plurality of capsules in the solid polymer matrix, the activator in the solid polymer matrix, and the accelerant in the solid polymer matrix. | 12-30-2010 |
| 20100315083 | Nuclear Magnetic Resonance Method for Quantitative and Qualitative Measurement of Natural Products - Provided herein are various methods and systems for analyzing natural products by quantitative proton nuclear magnetic resonance (qHNMR). A method is provided for quantitative and qualitative determination of a natural product by | 12-16-2010 |
| 20100311665 | Method and Composition for Potentiating an Opiate Analgesic - Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans. | 12-09-2010 |
| 20100305219 | EMULSIONS AND FOAMS USING PATCHY PARTICLES - Provided are emulsions and foam compositions that include patchy particles having at least two different surface chemistries, such as Janus particles. Also provided are methods of stabilizing emulsions and foam compositions by adding patchy particles to such emulsions or foam compositions during the process of forming such emulsions or foam compositions or after formation thereof. Further provided are methods of controlling droplet size in an emulsion or foam composition by adding patch particles having at least two different surface chemistries to the emulsion or foam composition. Additional embodiments are disclosed. | 12-02-2010 |
| 20100301730 | HIGH INTENSITY DISCHARGE ARC LAMP USING UV-ABSORBANT COATING - A high intensity discharge arc lamp comprises an arc tube, a metal halide in the arc tube, and a coating on the arc tube. The coating comprises a UV absorbent material. | 12-02-2010 |
| 20100289413 | ELECTRON INJECTION-CONTROLLED MICROCAVITY PLASMA DEVICE AND ARRAYS - An embodiment of the invention is a microcavity plasma device that can be controlled by a low voltage electron emitter. The microcavity plasma device includes driving electrodes disposed proximate to a microcavity and arranged to contribute to generation of plasma in the microcavity upon application of a driving voltage. An electron emitter is arranged to emit electrons into the microcavity upon application of a control voltage. The electron emitter is an electron source having an insulator layer defining a tunneling region. The microplasma itself can serve as a second electrode necessary to energize the electron emitter. While a voltage comparable to previous microcavity plasma devices is still imposed across the microcavity plasma devices, control of the devices can be accomplished at high speeds and with a small voltage, e.g., about 5V to 30V in preferred embodiments. | 11-18-2010 |
| 20100289124 | Printable Semiconductor Structures and Related Methods of Making and Assembling - The present invention provides a high yield pathway for the fabrication, transfer and assembly of high quality printable semiconductor elements having selected physical dimensions, shapes, compositions and spatial orientations. The compositions and methods of the present invention provide high precision registered transfer and integration of arrays of microsized and/or nanosized semiconductor structures onto substrates, including large area substrates and/or flexible substrates. In addition, the present invention provides methods of making printable semiconductor elements from low cost bulk materials, such as bulk silicon wafers, and smart-materials processing strategies that enable a versatile and commercially attractive printing-based fabrication platform for making a broad range of functional semiconductor devices. | 11-18-2010 |
| 20100272140 | High speed light emitting semiconductor methods and devices - A method for producing a high frequency optical signal component representative of a high frequency electrical input signal component, includes the following steps: providing a semiconductor transistor structure that includes a base region of a first semiconductor type between semiconductor emitter and collector regions of a second semiconductor type; providing, in the base region, at least one region exhibiting quantum size effects; providing emitter, base, and collector electrodes respectively coupled with the emitter, base, and collector regions; applying electrical signals, including the high frequency electrical signal component, with respect to the emitter, base, and collector electrodes to produce output spontaneous light emission from the base region, aided by the quantum size region, the output spontaneous light emission including the high frequency optical signal component representative of the high frequency electrical signal component; providing an optical cavity for the light emission in the region between the base and emitter electrodes; and scaling the lateral dimensions of the optical cavity to control the speed of light emission response to the high frequency electrical signal component. | 10-28-2010 |
| 20100263094 | Methods for Producing Fertile Crosses between Wild and Domestic Soybean Species - Methods for producing hybrids between domestic and wild soybean that are fertile and can be further bred with other soybean plants are provided, thus allowing transfer of desirable traits and genes from the wild soybean into the domestic soybean. This invention also provides novel media for producing callus and multiple somatic embryos, as well as novel media for producing multiple shoots from the embryos. The hybrid plants are made fertile by colchicine treatment to double their chromosome number so that they can be backcrossed into domestic soybean. These methods and media allow the production of elite soybean lines containing traits or genes from wild soybean as well as a minimum amount of additional wild soybean DNA. Backcrosses containing only one wild soybean chromosome can be produced, as well as sets of such backcrossed lines that each contain one chromosome from the wild ancestor, but collectively all the wild chromosomes from the hybrid ancestor. Plants and plant progeny and plant tissue (tissue including seeds) of plants produced by the foregoing methods are also provided. The methods do not require genetic modification, and thus this invention allows production of domestic soybean plants that are not genetically-modified organisms (non-GMO) but that express desirable traits derived from wild soybean. | 10-14-2010 |
| 20100261666 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MYOCARDIAL DYSFUNCTION ASSOCIATED WITH SIRS OR SEPSIS - Provided are compositions and methods for the treatment of myocardial dysfunction associated with SIRS or sepsis, which methods comprise the administration to a patient in need thereof of a composition comprising one or more adenosine deaminase (ADA) inhibitor and/or one or more xanthine oxidase (XO) inhibitor. Exemplified herein are methods for the treatment of myocardial dysfunction, which methods comprise the administration of a composition comprising the ADA inhibitor pentostatin and/or a composition comprising the XO inhibitor allopurinol. Advantageously, the methods disclosed herein that employ the administration of one or more ADA inhibitor(s) do not significantly affect cardiac TNF-α mRNA expression and/or protein levels. | 10-14-2010 |
| 20100260828 | Modulation of Platelet Aggregation - Methods and compositions for inhibition of platelet cell aggregation are described. In particular, compositions comprising cell permeant RGT peptides, such as RGT bound to a lipid moiety are provided. Compositions may be used in the treatment and prevention of clot related diseases such as stroke and myocardial infarction. | 10-14-2010 |
| 20100208252 | Matched Pulse Stimulated Raman Scattering - Methods and apparatus for selectively driving the vibrations of normal modes of a target molecule into coherence using stimulated Raman scattering. In concert, many vibrations produce a larger anti-Stokes signal than a single vibration. The same illumination does not drive other molecules to have coherent vibrations, so these molecules produce a weaker signal. Target and confounder molecules can be distinguished by pulses that drive many vibrations coherently, with applications in coherent Raman microspectroscopy. | 08-19-2010 |
| 20100206088 | Self-Assessing Mechanochromic Materials - A mechanochromic material includes a polymer having a backbone containing a mechanophore. | 08-19-2010 |
| 20100203141 | STIMULI-RESPONSIVE LOW SOLUBILITY HYDROGEL COPOLYMERS OF N-ISOPROPYL ACRYLAMIDE AND SYNTHESIS METHOD - Preferred embodiment stimuli-responsive low solubility copolymer hydrogel compositions of the invention include polymerized N-isopropylacrylamide and water insoluble monomer or oligomer repeating units. The repeating units are arranged within the polymer backbone of the copolymer hydrogel. In a preferred fabrication method, precursors of N-isopropylacrylamide and precursors of the water insoluble monomer of oligomer are solved in a liquid solvent to form a solution in a container. An initiator is added to the solution. Gas is bubbled through the solution, and the container is sealed. The solution is stirred while heating to a polymerization temperature and polymerization is permitted to complete to form the copolymer hydrogel composition. | 08-12-2010 |
| 20100196932 | Yeast Reporter System - Cell-based screens for compounds that inhibit the accumulation of amyloids are described. For example, the herein described screens may be used to assay the formation, or inhibition, of pre-amyloid or amyloid aggregates and/or oligomers. Agents have been identified that interfere with, or inhibit, the oligomerization of the major component of amyloid plaques; a | 08-05-2010 |
| 20100195683 | CURVED COUPLED WAVEGUIDE ARRAY AND LASER - A semiconductor laser that includes an active region, claddings and electrical contacts to stimulate emissions from the active region, where a coupled waveguide guides emission. The waveguide includes a broad area straight coupling region that fans out into an array of narrower Individual curved coupled waveguides at an output facet of the laser. The individual curved coupled waveguides are curved according to Lorentzian functions that define the waveguide curvature as a function of position along the device. The integral length of each individual curved coupled waveguide differs from adjacent individual curved coupled waveguides by an odd number of half- wavelengths. The coupled waveguide array shapes the optical field output of the semiconductor laser such that a large fraction of the power is emitted into a small angular distribution using interference phenomena. A laser of the invention produces high power output with a very high quality, narrow beam shape. | 08-05-2010 |
| 20100184725 | Method and Composition for Treating Alzheimer's Disease and Dementias of Vascular Origin - A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans. | 07-22-2010 |
| 20100173975 | Expressed Pseudogene Regulates Gene Expression - Selective expression of a pseudogene of myosin light chain kinase is found in cancer cells and tissues but not in normal cells and tissues. The pseudogene is expressed, and when expressed it inhibits expression of the ancestral myosin light chain kinase. This widespread expression among cancer cell types and the selective expression in cancer cells versus normal cells opens the door to many diagnostic and therapeutic applications. | 07-08-2010 |
| 20100173872 | Method and Composition for Treating Alzheimer's Disease and Dementias of Vascular Origin - A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans. | 07-08-2010 |
| 20100159706 | METHOD OF PLASMA ETCHING GA-BASED COMPOUND SEMICONDUCTORS - A method of plasma etching Ga-based compound semiconductors includes providing a process chamber and a source electrode adjacent to the process chamber. The process chamber contains a sample comprising a Ga-based compound semiconductor. The sample is in contact with a platen which is electrically connected to a first power supply, and the source electrode is electrically connected to a second power supply. The method includes flowing SiCl | 06-24-2010 |
| 20100159705 | METHOD OF PLASMA ETCHING GA-BASED COMPOUND SEMICONDUCTORS - A method of plasma etching Ga-based compound semiconductors includes providing a process chamber and a source electrode adjacent thereto. The chamber contains a Ga-based compound semiconductor sample in contact with a platen which is electrically connected to a first power supply, and the source electrode is electrically connected to a second power supply. SiCl | 06-24-2010 |
| 20100158979 | TEMPORAL RELEASE OF GROWTH FACTORS FROM 3D MICRO ROD SCAFFOLDS FOR TISSUE REGENERATION - The present invention relates to the use of three-dimensional microrod scaffolds for the temporal release of growth factors useful in tissue regeneration, engineering and treatment of disorders. | 06-24-2010 |
| 20100152450 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF - The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand. | 06-17-2010 |
| 20100144885 | HISTONE ACETYL TRANSFERASE ACTIVATORS AND HISTONE DEACETYLASE INHIBITORS IN THE TREATMENT OF ALCOHOLISM - The present invention relates to the reduction of a symptom of an alcohol withdrawal state comprising administering a modulator of histone acetylation. | 06-10-2010 |
| 20100137251 | Functional Role for Cannabinoids in Autonomic Stability During Sleep - The present invention relates generally to pharmacological methods for the prevention or amelioration of sleep-related breathing disorders via administration of cannabimimetic agents and combinations thereof. | 06-03-2010 |
| 20100121522 | METHOD AND APPARATUS FOR SHARING TRAFFIC INFORMATION - A system that incorporates teachings of the present disclosure may include, for example, a communication device having a controller to receive from a system a broadcasted vehicle velocity, detect that a difference between a velocity of a vehicle carrying the communication device and the broadcasted vehicle velocity exceeds a threshold, and determine from a random policy whether to transmit the velocity of the vehicle to the system. Additional embodiments are disclosed. | 05-13-2010 |
| 20100121062 | Slow Release of Organoboronic Acids in Cross-Coupling Reactions - A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: | 05-13-2010 |
| 20100113396 | Method and Composition for Potentiating an Opiate Analgesic - Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans. | 05-06-2010 |
| 20100105601 | METHOD FOR TREATING A SYNUCLEINOPATHY - The present invention relates to methods for restoring fast axonal transport in a cell which expresses a pathological synuclein protein and for treating a synucleinopathy using a Protein Kinase C mu or Src-Family Tyrosine Kinase inhibitor. | 04-29-2010 |
| 20100098663 | Methods of Inhibiting Tumor Cell Proliferation with FoxM1 siRNA - The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B (also called FoxM1) activity in a tumor cell. The invention also provides FoxM1B siRNA molecules and pharmaceutical compositions comprising FoxM1B siRNA molecules, wherein the siRNA molecules can inhibit FoxM1B activity and can inhibit proliferation of tumor cells. The invention further provides methods for preventing tumor growth, progression or both in an animal comprising inhibiting FoxM1B activity using siRNA molecules or pharmaceutical compositions comprising FoxM1B siRNA molecules. | 04-22-2010 |
| 20100089410 | APPARATUS AND METHOD FOR AIRWAY PATENCY AND HEAD IMMOBILIZATION - A jaw-thrust device includes a base with an extension arm disposed on each side of a patient's head mounted on the base. A mandible rest is mounted on each extension arm such that the mandible rest may be deployed proximate to a patient's mandible. A chin pad and at least one connector connects the chin strap to at least one of the base or extension arm; whereby jaw thrusting pressure on the mandible rests causes rotational force on the chin straps such that the patient's mouth opens without substantially tilting the patient's head. The device maintains an open airway unattended. | 04-15-2010 |
| 20100088788 | STRESS MICRO MECHANICAL TEST CELL, DEVICE, SYSTEM AND METHODS - The invention provides a stress micro mechanical system for measuring stress and strain in micro- and nano-fibers tubes, and wires as well as for measuring the interface adhesion force and stress in nanofibers and nanotubes embedded in a polymer matrix. A preferred system of the invention has a substrate for supporting a MEMS fabrication. The MEMS fabrication includes freestanding sample attachment points that are movable in a translation direction relative to one another when the substrate is moved and a sample is attached between the sample attachment points. An optical microscope images surfaces of the MEMS fabrication. Software conducts digital image correlation on obtained images to determine the movement of the surfaces at a resolution much greater than the hardware resolution of the optical microscope. A preferred method for measuring stress and strain in micro- and nano-fibers, tubes, and wires, and/or measuring the force required to pull-out individual micro- and nano-fibers, tubes, and wires from a polymer matrix and to therefore measure interfacial adhesion is also provided. In the method a sample is attached between freestanding platforms in a MEMS device. Relative translational movement between the platforms is created and motion of the platforms is imaged with an optical microscope. Mechanical and adhesion properties of the sample are determined by applying a digital image correlation algorithm to the image data. | 04-08-2010 |
| 20100083396 | Soybean Gene for Resistance to Aphis glycines | 04-01-2010 |
| 20100075134 | Interfacial Functionalization For Self-Healing Composites - A reinforced composite material includes a solid polymer matrix, a reinforcing material in the solid polymer matrix, and a first plurality of capsules. The reinforcing material includes a surface. The capsules are on the surface of the reinforcing material, and include a liquid healing agent. The amount of the healing agent of the capsules is at least 0.01 milligrams per square centimeter of the surface area of the reinforcing material. | 03-25-2010 |
| 20100072893 | ELLIPSOIDAL MICROCAVITY PLASMA DEVICES AND POWDER BLASTING FORMATION - The invention provides microcavity plasma devices and arrays that are formed in layers that also seal the plasma medium, i.e., gas(es) and/or vapors. No separate packaging layers are required and additional packaging can be omitted if it is desirable to do so. A preferred microcavity plasma device includes first and second thin layers that are joined together. A half ellipsoid microcavity or plurality of half ellipsoid microcavities is defined in one or both of the first and second thin layers, and electrodes are arranged with respect to the microcavity to excite a plasma within said microcavities upon application of a predetermined voltage to the electrodes. A method for forming a microcavity plasma device having a plurality of half or full ellipsoid microcavities in one or both of first and second thin layers is also provided by a preferred embodiment. The method includes defining a pattern of protective polymer on the first thin layer. Powder blasting forms half ellipsoid microcavities in the first thin layer. The second thin layer is joined to the first layer. The patterning can be conducted lithographically or can be conduced with a simple screen. | 03-25-2010 |
| 20100072577 | Methods and Devices for Fabricating and Assembling Printable Semiconductor Elements - The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations. | 03-25-2010 |
| 20100061970 | CBLB for Treating Endotoxin-Mediated Disorders - Methods of treating endotoxin-mediated disorders are provided. | 03-11-2010 |
| 20100059863 | Stretchable Form of Single Crystal Silicon for High Performance Electronics on Rubber Substrates - The present invention provides stretchable, and optionally printable, semiconductors and electronic circuits capable of providing good performance when stretched, compressed, flexed or otherwise deformed. Stretchable semiconductors and electronic circuits of the present invention preferred for some applications are flexible, in addition to being stretchable, and thus are capable of significant elongation, flexing, bending or other deformation along one or more axes. Further, stretchable semiconductors and electronic circuits of the present invention may be adapted to a wide range of device configurations to provide fully flexible electronic and optoelectronic devices. | 03-11-2010 |
| 20100055199 | SYNTHESIS OF NANOPARTICLES BY FUNGI - Systems and methods for synthesizing silver nanoparticles (SNPs) using | 03-04-2010 |
| 20100027027 | Jones phase microscopy of transparent samples - Methods for displaying anisotropic properties of an object. The object is illuminated with a first test beam characterized by a first polarization that, after traversing the object, is combined with a reference beam. The combined light of the first transmitted test beam and the reference beam is analyzed by a first pair of polarization analyzers, and interference created between the first transmitted test beam and the reference beam as analyzed by the first pair of analyzers is detected to derive intensity, phase and polarization of the first transmitted test beam. The same is then done with a second test beam that has a polarization with a component orthogonal to the first polarization. Based on the two analyzed beams, complex elements of a Jones matrix associated with the object in a local coordinate system are determined and a plurality of tangible images are displayed that characterize the object based on the complex elements of the Jones matrix. | 02-04-2010 |
| 20100013483 | Tunable Radio-Frequency Coil - A radio frequency (RF) coil comprising a plurality of electrically uninterrupted conductive legs, each leg having a first end and a second end, and at least one continuous conductor electrically connected to the first ends of the legs. Frequency tuning of the coil is achieved by translating, along the legs, an electrically continuous tuning band that includes a capacitor closed about the axis of the coil in proximity to the conductive legs. Maintaining electrical symmetry of the coil results in tuning ranges of at least 30 percent of the nominal value of the resonant frequency. | 01-21-2010 |
| 20100010610 | ANASTOMOSIS STENT AND GRAFT APPARATUS AND METHOD - An anastomosis graft/stent apparatus comprising a first stent portion, a second stent portion and a graft. The graft is between the first and second stent portions. A port is in the graft portion and provides access to a vessel lumen at the anastomosis site, with the access being sufficient to remove thrombotic material. | 01-14-2010 |
| 20090325887 | PEPTIDES AND REGULATION OF CALCIUM CHANNELS - Calcium channels can be regulated by natural gamma proteins. Herein we disclose embodiments of compositions and methods, particularly involving short peptides which are capable of regulating calcium channel function. Certain short peptides which can inhibit calcium current have structural features from the first transmembrane domain of gamma6 such as a GxxxA motif and adjoining aliphatic residues. In embodiments the peptide compositions and methods are capable of selective efficacy for low voltage-activated calcium channels, such as LVA channel Cav3.1, versus high voltage-activated channels. | 12-31-2009 |
| 20090325254 | HIGHLY ACTIVE XYLOSE REDUCTASE FROM NEUROSPORA CRASSA - A new xylose reductase encoding gene from | 12-31-2009 |
| 20090323014 | PASSIVE AND ACTIVE PHOTONIC CRYSTAL STRUCTURES AND DEVICES - The present invention provides photonic crystal devices, device components and methods for preventing transmission of electromagnetic radiation from one or more laser sources or laser modes so as to provide an optical shield for protecting a users eyes or an optical sensor. The present invention also provides dynamic photonic crystals and devices incorporating dynamic photonic crystals for optically modulating the intensity of one or more beams of electromagnetic radiation and other optical switching applications. | 12-31-2009 |
| 20090306489 | APPARATUS AND METHOD FOR MEASURING A CHARACTERISTIC OF A COMPOSITION REACTIVE TO A MAGNETIC FIELD - A system that incorporates teachings of the present disclosure may include, for example, a sensor having a pulse oximeter sensor to measure an oxygen saturation level in a liquid, a magnetic source coupled to the pulse oximeter sensor, and a controller to control the pulse oximeter sensor and the magnetic source, and to measure a mechanical effect on the liquid responsive to the magnetic source applying a magnetic field to the liquid. Additional embodiments are disclosed. | 12-10-2009 |
| 20090304788 | ENCAPSULATED MATERIALS AND METHODS FOR ENCAPSULATING MATERIALS - A system that incorporates teachings of the present disclosure may include, for example, an apparatus having an outer nozzle operable to discharge an outer stream of a shell solution, and an inner nozzle operable to discharge an inner stream of a core solution intermixed with a plurality of materials. The outer stream can substantially surrounds the inner stream, thereby forming a combined stream. A plurality of capsules can be formed responsive to a force applied to the combined stream. At least a portion of the plurality of capsules are desirable capsules, each having a core encapsulated by a portion of the shell solution. The core can have at least one of the plurality of materials encapsulated by a portion of the core solution without protruding an outer surface of the portion of the shell solution. Additional embodiments are disclosed. | 12-10-2009 |
| 20090304647 | Production of Neural Stem Cells from Bone Marrow Tissue and Use Thereof - The invention provides reagents and methods for preparing mammalian mesenchymal-derived neural stem cells, especially autologous mesenchymal-derived neural stem cells, compositions thereof, and methods for using and administering the cells in a patient in need thereof. | 12-10-2009 |
| 20090299483 | SYSTEM AND METHOD FOR PROSTHETIC FITTING AND BALANCING IN JOINTS - A system and method for prosthesis fitting in joints comprising an artificial condyle and a spacer which cooperates with the condyle to form an artificial joint. The spacer embedded with at least one sensor which is responsive to a force generated between the condyle and the spacer. The artificial joint is adapted to move between a flexed position and an extended position defining a range of motion. The sensor is responsive to the force and generates an output representative of that force. The output is transmitted, either wirelessly or other, to a processor which utilizes an analysis program to display a representation of the forces applied. A practitioner utilizing the displayed analysis may intraoperatively determine the adjustments and balancing required within the artificial joint. The system may also utilize a ligament tension sensor which generates generates data representative of tension on a ligament of the artificial joint, and a joint angle sensor responsive to the range of motion of the artificial joint. The processor may be adapted to store the outputted sensor data to provide the practitioner with statistically relevant historical data. | 12-03-2009 |
| 20090296188 | Energy-Efficient Optoelectronic Smart Window - In an aspect, described herein is a dynamically controllable optoelectronic smart window which utilizes a diffraction grating for selective transmission or rejection of a specific region of the electromagnetic spectrum, for example the infrared, near-infrared and/or visible regions. Window embodiments described herein may further utilize a selectively controlled and/or patterned total internal reflection layer to assist with the selective rejection of a specific spectral region while allowing for transmission of another specific spectral region. In another aspect, the present invention provides methods for dynamically controlling the transmission or rejection of solar near-infrared and/or visible radiation. | 12-03-2009 |
| 20090294803 | METHODS AND DEVICES FOR FABRICATING AND ASSEMBLING PRINTABLE SEMICONDUCTOR ELEMENTS - The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations. | 12-03-2009 |
| 20090281451 | APPARATUS AND METHODS FOR MAPPING RETINAL FUNCTION - The present invention provides an electrode array device for simultaneously detecting electrical potentials at five or more locations on the anterior surface of an eye. The device comprises a dielectric lens substrate having a concave inner surface conforming to the anterior surface of the eye, and at least five recording electrodes positioned in relation to the inner surface of the lens substrate so as to make electrical connection with the anterior surface of the eye when the lens substrate is placed on the anterior surface of eye. Each recording electrode is in electrically conductive communication with a corresponding conductive contact, there being one conductive contact for each recording electrode. Each conductive contact is adapted for operable connection to signal processor, and each conductive contact is electrically insulated from the anterior surface of the eye. A computational method for analyzing electrophysiological potentials recorded at five or more locations on the anterior surface of the eye, which reflect the spatial distribution of activity of the retina, is also provided. | 11-12-2009 |
| 20090276019 | ELECTROMAGNETIC FIELD THERAPY DELAYS CELLULAR SENESCENCE AND DEATH BY ENHANCEMENT OF THE HEAT SHOCK RESPONSE - Disclosed herein is a method comprising repetitive electromagnetic field shock to at least one living cell, wherein the repetitive electromagnetic field shock improves HSF1 and/or HSR function, and producing delaying and reversal of aging and age related diseases. Also disclosed herein is an apparatus adapted to deliver repetitive electromagnetic field shock to at least one living cell, wherein the repetitive electromagnetic field shock improves HSF1 and HSR function. | 11-05-2009 |
| 20090275137 | HIGH AFFINITY TCR PROTEINS AND METHODS - T cell receptors (TCRS) that have higher affinity for a ligand than wild type TCRs are provided. These high affinity TCRs are formed by mutagenizing a T cell receptor protein coding sequence to generate a variegated population of mutants of the T cell receptor protein coding sequence; transforming the T cell receptor mutant coding sequence into yeast cells; inducing expression of the T cell receptor mutant coding sequence on the surface of yeast cells; and selecting those cells expressing T cell receptor mutants that have higher affinity for the peptide/MHC ligand than the wild type T cell receptor protein. The high affinity TCRs can be used in place of an antibody or single chain antibody. | 11-05-2009 |
| 20090269786 | RHO1-Gamma Amino Butyric Acid C Receptor-Specific Antibodies - This invention provides antibodies immunologically specific for ρ1-GABA | 10-29-2009 |
| 20090258153 | APPARATUS AND METHOD FOR APPLYING A FILM ON A SUBSTRATE - A system that incorporates teachings of the present disclosure may include, for example, an apparatus having a plurality of applicators, each applicator with an ingress opening to receive a liquid, and an egress opening to release the liquid, and a conductor positioned in a conduit of each of the plurality of applicators, the conductor and the conduit having dimensions to cause a surface tension of the liquid to prevent a constant flow of the liquid from the egress opening. Each conductor of the plurality of applicators can be coupled to one of one or more power sources operable to apply a charge to the liquid to overcome the surface tension and form at the egress opening of each applicator a plurality of jet sprays of the liquid applicable on a substrate to form a thin film. Additional embodiments are disclosed. | 10-15-2009 |
| 20090257950 | Membrane Scaffold Proteins - The membrane scaffold proteins (MSP) of the present invention assemble with hydrophobic or partially hydrophobic proteins to form soluble nanoscale particles which preserve native structure and function; they are improved over liposomes and detergent micelles, both in terms of stability and preservation of biological activity and native conformation. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles, which are robust in terms of integrity and maintenance of biological activity of incorporated proteins, facilitate pharmaceutical and biological research, structure/function correlations, structure determinations, bioseparations, and drug discovery. | 10-15-2009 |
| 20090247533 | Ecteinascidins - The present invention is directed to several newly discovered ecteinascidin (Et) species, designated herein as Et 731, Et 815, Et 808, and Et 594. The physical properties of these compounds, their preparation and therapeutic properties are also reported. | 10-01-2009 |
| 20090232854 | USES OF BISPECIFIC ANTIBODY COATED DENDRITIC CELLS PULSED WITH ANTIGENS AND GM-CSF IN IMMUNE REGULATION - GM-CSF administered before immunization exerted a sustained suppressive effect against the induction of myasthenia gravis (MG). This suppression was associated with lowered serum autoantibody levels, reduced T cell proliferative responses to AChR, and an expansion in the population of FoxP3+ regulatory T cells. Manipulating DCs to expand regulatory T cells is useful for the control of autoimmune diseases such as myasthenia gravis MG. | 09-17-2009 |
| 20090230324 | Methods and Devices for Characterizing Particles in Clear and Turbid Media - The invention provides methods and devices for detecting, identifying, classifying and characterizing particles in a fluid sample. Optical analyzers are provided having a rotating and/or translating sample container for measuring the concentrations of fluorescent particles present in very low concentrations and for characterizing fluorescent particles on the basis of size, shape, diffusion constant and/or composition. Scanning optical analyzers are provided using pattern recognitions data analysis techniques and multichannel detection. | 09-17-2009 |
| 20090230222 | APPARATUSES AND METHODS FOR APPLYING ONE OR MORE MATERIALS ON ONE OR MORE SUBSTRATES - A system that incorporates teachings of the present disclosure may include, for example, an apparatus having a tube with an ingress opening to receive a liquid, and an egress opening to release the liquid, a conductor positioned in a conduit of the tube, the conductor and the conduit having dimensions to cause a surface tension of the liquid to prevent a constant flow of the liquid from the egress opening, and a power supply coupled to the conductor to apply a charge to the liquid to overcome the surface tension and form at the egress opening a single jet stream of the liquid applicable on a substrate to create a pattern. The single jet stream can be controllable in part by a viscosity of the liquid. Additional embodiments are disclosed. | 09-17-2009 |
| 20090221658 | Pharmacological Treatment for Sleep Apnea - The present invention relates generally to pharmacological methods for the prevention or amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity. | 09-03-2009 |
| 20090213662 | MEMORY DEVICE AND APPLICATIONS THEREOF - A system that incorporates teachings of the present disclosure may include, for example, a memory device having a memory cell to selectively store holes by photon and bias voltage induction as a representation of binary values. Additional embodiments are disclosed. | 08-27-2009 |
| 20090209858 | SYSTEM AND METHOD FOR ULTRASONIC IMAGE PROCESSING - A system that incorporates teachings of the present disclosure may include, for example, an ultrasonic (US) imaging system having a transducer, and a controller managing operations of the transducer. The controller can be operative to cause the transducer to transmit a coded ultrasound signal to an object, cause the transducer to receive an altered coded ultrasound signal from the object, decode the altered coded ultrasound signal to attain a desired bandwidth that exceeds an impulse response of the US imaging system, subdivide the attained bandwidth of the decoded ultrasound signal into a plurality of sub-bands, and generate an image for each sub-band from signals included in each sub-band of the decoded ultrasound signal. Additional embodiments are disclosed. | 08-20-2009 |
| 20090155206 | Methods, Compositions and Articles of Manufacture for Contributing to the Treatment of Cancers - Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ET | 06-18-2009 |
| 20090140157 | IONIZING RADIATION SENSOR - A system that incorporates teachings of the present disclosure may include, for example, an ionizing radiation sensor having a first scintillator for generating photons from incoming ionizing radiation, an imaging intensifier for amplifying the photons, and an electron-multiplying charge-coupled device (EMCCD) coupled to the imaging intensifier for sensing the amplified photons generated by the imaging intensifier. Additional embodiments are disclosed. | 06-04-2009 |
| 20090128553 | IMAGING OF ANATOMICAL STRUCTURES - A system that incorporates teachings of the present disclosure may include, for example, an imaging device having a Magnetic Resonance Image (MRI) scanner to generate MRI data associated with soft tissue of a patient, and supply said MRI data to diagnostic equipment that selects one or more normative soft tissue profiles of a select anatomical section, and generates a three dimensional soft tissue image from the MRI data and the one or more normative soft tissue profiles. Additional embodiments are disclosed. | 05-21-2009 |
| 20090123581 | COLLAGEN CROSS-LINKING AGENTS ON DENTAL RESTORATIVE TREATMENT AND PREVENTIVE DENTISTRY - The invention relates to the development of compositions and methods for increasing the amount of collagen cross-linking in a mammalian tissue. A typical composition as described herein includes at least one cross-linking agent such as a bioflavonoid compound (e.g., proanthocyanidin), a grape seed extract, a Casein Phosphopeptide-amorphous Calcium Phosphate, or an iridoid compound (e.g., genipin) in an amount effective for increasing collagen cross-linking in the mammalian tissue in a pharmaceutically acceptable carrier. A typical method for increasing the amount of collagen cross-linking in dentin in a mammalian tooth includes the steps of preparing the surface of the tooth to be treated; and applying a composition including at least one of: a bioflavonoid compound, a grape seed extract, a Casein Phosphopeptide-amorphous Calcium Phosphate, and an iridoid compound in a pharmaceutically acceptable carrier to the tooth surface for a time period of 0.0001 hours to about 4 hours. In some embodiments, two or more cross-linking agents are included in the compositions described herein. The compositions and methods as described herein are particularly useful for applying to dentin in a mammalian tooth requiring a restorative procedure for improving the mechanical properties of restoration interfaces to withstand degradation over time. Compositions containing one of the collagen cross-linking agents as described herein were applied to dentin collagen and resulted in a significant improvement in ultimate tensile strength indicating the value of these compositions in restorative dentistry. The compositions and methods described herein will also find use in preventive dentistry applications, and can be applied to sound dentin, caries-affected dentin, and dentin that is impaired, weak, or degraded in any way. | 05-14-2009 |
| 20090118191 | Anti-Antiogenic Fragments of Pigment Epithelium-Derived Factor (PEDF) - The present invention provides anti-angiogenic derived from pigment epithelium-derived factor (PEDF) pharmaceutical compositions comprising the peptides, and methods of preventing angiogenesis. Such methods are useful in treating angiogenesis-associated disorders and diseases. | 05-07-2009 |
| 20090112489 | METHODS AND SYSTEMS FOR MODELING MATERIAL BEHAVIOR - A method for modeling material behavior includes using empirical three dimensional non-uniform stress and strain data to train a self-organizing computational model such as a neural network. A laboratory device for measuring non-uniform stress and strain data from material includes an enclosure with an inclusion in it. As the enclosure is compressed, the inclusion induces a non-uniform state of stress and strain. A field testing device includes a body having a moveable section. When the body is inserted in a material and the moveable section moved, a non-uniform state of stress and strain can be characterized. | 04-30-2009 |
| 20090086216 | Partially Coherent Illumination For Inverse Scattering Full-Field Interferometric Synthetic Aperture Microscopy - Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of light characterized by partial spatial coherence. The beam is focused onto a sample and scattered light from the sample is superposed with a reference beam derived from the source onto a focal plane detector array to provide an interference signal. A forward scattering model is derived relating measurement data to structure of an object to allow solutions of an inverse scattering problem, based upon the interference signal so that a three-dimensional structure of the same may be inferred. The partial spatial coherence of the source, which may be fixed or variable, may advantageously provide for rejection of multiple scattering artifacts and thus improve image quality. | 04-02-2009 |
| 20090084688 | SOLID STATE DEVICE - A system that incorporates teachings of the present disclosure may include, for example, a solid-state selector having a vessel for carrying a liquid medium with one or more molecules surrounded by ions, a solid state conductive structure doped with impurities having one or more through-holes extending between two surfaces of the solid state conductive structure positioned within the liquid medium of the vessel, a voltage source coupled to the solid state conductive structure to selectively stimulate the ions surrounding the one or more molecules to pass through the one or more through-holes. Additional embodiments are disclosed. | 04-02-2009 |
| 20090081734 | Arabinitol Dehydrogenases from Neurospora crassa - Stable and active arabinitol dehydrogenases (LAD) from | 03-26-2009 |
| 20090075929 | IG20 SPLICE VARIANTS THERAPEUTICS FOR CANCER - Methods and compositions inhibit the growth of cancer cells by selectively down-regulating the expression of an IG20 splice variant including MADD. Specific knock-down of MADD splice variant resulted in the apoptosis of cancer cells. Interfering RNAs including small hairpin RNAs (shRNA) to down-regulate MADD expression in vivo are disclosed. Inhibition of MADD phosphorylation by Akt results in activation of cancer cell death. Down-regulation of MADD expression results in switching to apoptotic mode due to lack of MAPK activation upon TNF-α-based induction. | 03-19-2009 |
| 20090055691 | METHOD AND SYSTEM FOR MANAGING A NETWORK OF SENSORS - A system and method are disclosed for managing a network of sensors ( | 02-26-2009 |
| 20090054328 | Reagents and Methods for Modulating Gene Expression Related to Hypertension - This invention relates to gene expression and proliferation in eukaryotic, preferably mammalian and most preferably human cells. The invention specifically relates to hypertension associated with proliferation and contractility of vascular smooth muscle cells. | 02-26-2009 |
| 20090048823 | SYSTEM AND METHODS FOR OPINION MINING - A system that incorporates teachings of the present disclosure may include, for example, a system having a controller to identify from commentaries of an object or service one or more context-dependent opinions associated with one or more features of the object or the service, and synthesize a semantic orientation for each of one or more context-dependent opinions of the one or more features. Additional embodiments are disclosed. | 02-19-2009 |
| 20090047356 | TISSUE FACTOR COMPOSITIONS AND METHODS - Tissue Factor (natural or recombinant truncated) can be incorporated into stable, soluble nanoscale particles so that activity is maintained. These particles can be used as a reagent in prothrombin clotting time assays or they can be used in therapeutic compositions for use in humans or animals. Therapeutic settings can include supplementation in the case of a genetic deficiency, uncontrolled bleeding, surgical incisions or seepage, thrombocytopenia, soft tissue trauma or other trauma, to effect tumor regression or to inhibit tumor growth. | 02-19-2009 |
| 20090030300 | ACCURATE DETERMINATION OF INTRAOCULAR PRESSURE AND CHARACTERIZATION OF MECHANICAL PROPERTIES OF THE CORNEA - A computer-implemented method for accurate determination of intraocular pressure (IOP) and characterization of mechanical properties of a cornea is provided that includes measuring a cornea with a probe tonometer to produce at least force versus displacement data over a range of applied forces; and forming a model of corneal constitutive parameters, with a computer having a processor, based on the data obtained by the probe tonometer to more accurately determine IOP and characterize mechanical properties of the cornea, wherein the computer is coupled with the probe tonometer. | 01-29-2009 |
| 20090028178 | Encoding and Decoding Messages on Noisy Timing Channels - In accordance with one or more aspects of the encoding and decoding messages on noisy timing channels, a message is encoded, based at least in part on a cumulative distribution function, in inter-arrival timings of data packets. The data packets are output to a device with the message in the inter-arrival timings of the data packets. A the device, the inter-arrival timings of the data packets are identified. The message encoded in the inter-arrival timings is decoded based at least in part on a model representing noise between a source of the data packets and the device. | 01-29-2009 |
| 20090022761 | Enhancement of Immune Response to Vaccine by Interferon Alpha - Exogenous cDNA capable of expressing interferon″ activity, exogenous interferon″ protein, inducers of endogenous interferon″ protein activity, inducers of endogenous interferon $ protein activity, inducers of endogenous interferon′ activity, or inducers of other immune-enhancing activity can be combined with a vaccine to enhance an immune response. Specifically disclosed are adjuvant and vaccine combinations where the adjuvant comprises a cDNA capable of expressing interferon″ activity, a complex comprising polyriboinosinic-polyribocytidilic acid, or a complex comprising polyriboinosinic-polyribocytidilic acid, poly-L-lysine, and carboxymethylcellulose and where the vaccine is a live vaccine virus derived from a virus causing porcine reproductive and respiratory syndrome disease. | 01-22-2009 |
| 20090005357 | Pharmacological Treatment for Sleep Apnea - The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity. | 01-01-2009 |
| 20090004677 | QUANTITATIVE DETERMINATION OF BCL10 - Methods of and kits for quantitatively determining the concentrations of Bcl10 in a biological sample were developed that provide an accurate means of identifying therapeutic molecules with a plurality of therapeutic effects. A solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) for human Bcl10 that provides reproducible, precise measurements was developed and characterized. The sensitivity of the assay is 0.25 ng/ml, enabling accurate detection of small quantities of Bcl10. The sensitive and specific, solid-phase, sandwich ELISA for Bcl10 is well-suited for the accurate determination of Bcl10 values in different experimental conditions, in immune and non-immune cells, and may find use in a clinical context. An ELISA as described herein may have particular clinical utility, since increased Bcl10 is associated with inflammation, infection and malignancy. | 01-01-2009 |
| 20080318906 | BISPHOSPHONATE COMPOUNDS AND METHODS FOR BONE RESORPTION DISEASES, CANCER, BONE PAIN, IMMUNE DISORDERS, AND INFECTIOUS DISEASES - Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as | 12-25-2008 |
| 20080305131 | Cancer Immunotherapy with Semi-Allogeneic Cells - The present invention relates to improved semi-allogeneic immunogenic cells which act to stimulate and induce an immunological response when administered to an individual. In particular, it relates to cells which express both allogeneic and syngeneic MHC determinants and which also express at least one antigen recognized by T lymphocytes. The invention is also directed to methods of inducing an immune response and methods of treating tumors by administering the semi-allogeneic immunogenic cells to an individual. | 12-11-2008 |
| 20080301765 | ANALYSIS OF DISTRIBUTED POLICY RULE-SETS FOR COMPLIANCE WITH GLOBAL POLICY - A method for analysis of distributed device rule-sets for compliance with global policies includes enabling an administrator to specify a network topology with intercommunicating elements and parameters required to secure the intercommunication with access control elements of the network topology; establishing connections to the access controls elements to capture a snapshot configuration of device rule-sets of the access control elements; enabling the administrator to specify a set of global access constraints with reference to the access control elements; enabling the administrator to select between exhaustive analysis and statistical analysis; conducting the selected analysis to determine violations by the device rule-sets that fail to comply with the set of global access constraints, wherein statistical analysis quantitatively characterizes a level of compliance without conducting analysis of all potential network paths; and providing results of the selected analysis to the administrator through a graphical user interface (GUI) as the results are obtained. | 12-04-2008 |
| 20080293915 | Nanoscale Neuromodulating Platform For Retina Neuron Activation Apparatus and Method - Postsynaptic membrance receptor proteins of retinal neurons proximal to the rods and cones mediate the transmission of visual signals at multiple types of chemical synapses in the normally functioning retina, and there is reason to believe that these proximal retinal neurons in certain cases remain functional despite the disease-induced loss of rod and cone visual signaling. The invention is a nanoscale molecular structure that can selectively attach to the extracellular face of specific membrane receptors of post-photoreceptor retinal neurons and, by modulating the postsynaptic receptor's activity in response to light, restore visual signaling in retina damaged by photoreceptor degenerative disease. | 11-27-2008 |
| 20080292627 | Compositions and Methods for Treating Mood and Anxiety Disorders - The invention relates method of disrupting the interface between Gsα and tubulin. The disruption of this interaction is a mechanism for treatment of mood and anxiety disorders and this interaction may be used to screen for and design therapeutics for mood and anxiety disorders. | 11-27-2008 |
| 20080290799 | AC-EXCITED MICROCAVITY DISCHARGE DEVICE AND METHOD - A method for fabricating microcavity discharge devices and arrays of devices. The devices are fabricated by layering a dielectric on a first conducting layer. A second conducting layer or structure is overlaid on the dielectric layer. In some devices, a microcavity is created that penetrates the second conducting layer or structure and the dielectric layer. In other devices, the microcavity penetrates to the first conducting layer. The second conducting layer or structure together with the inside face of the microcavity is overlaid with a second dielectric layer. The microcavities are then filled with a discharge gas. When a time-varying potential of the appropriate magnitude is applied between the conductors, a microplasma discharge is generated in the microcavity. These devices can exhibit extended lifetimes since the conductors are encapsulated, shielding the conductors from degradation due to exposure to the plasma. Some of the devices are flexible and the dielectric can be chosen to act as a mirror. | 11-27-2008 |
| 20080288085 | VIVO SYNTHESIS OF CONNECTIVE TISSUES - The in vivo synthesis of connective tissue by fibroblast or fibroblast precursor cells ensconced within a biocompatible scaffold is disclosed. The cells are preferably present in a biocompatible scaffold such as gelatin and placed between two other biocompatible scaffolds such as collagen sponges soaked with a collagenic amount of a member of the TGF-β family of proteins. This composition is then implanted in a host to produce cranial sutures, periodontal ligament or other fibrous tissue structures in vivo. | 11-20-2008 |
| 20080255163 | Use of Modified Pyrimidine Compounds to Promote Stem Cell Migration and Proliferation - This invention provides cells and methods for stimulating proliferation and migration of endogenous and exogenous mammalian stem cells in vivo and in vitro. The invention provides reagents and methods for efficiently proliferating mammalian stem cells in an animal in need thereof and producing stem cells that can be re-introduced into an animal in need thereof to alleviate neurological and corporal disorders. | 10-16-2008 |
| 20080255070 | Bisphosphonate Compounds and Methods with Enhanced Potency for Multiple Targets including FPPS, GGPPS, AND DPPS - The disclosure provides, inter alia, novel bisphosphonate compounds and methods of making and using such compounds. In certain embodiments, compounds of the invention include bisphosphonates that are capable of selectively inhibiting one or more of farnesyl diphosphate synthase (FPPS), geranylgeranyl diphosphate synthase (GGPPS), and decaprenyl pyrophosphate synthase (DPPS). In preferred embodiments, compounds of the invention are capable of selectively inhibiting two or more of FPPS, GGPPS, and DPPS. In embodiments, compounds and methods of the invention demonstrate superior activity levels, such as in the anti-cancer context, immunostimulation context, and other contexts, which in several cases exceed the activity levels of previous generation bisphosphonate drugs by orders of magnitude. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor or cancer cell growth inhibition, activation of gammadelta T cells, inhibition of certain enzymes related to the mevalonate metabolic pathway, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases. | 10-16-2008 |
| 20080241900 | HIGHLY ACTIVE XYLOSE REDUCTASE FROM NEUROSPORA CRASSA - A new xylose reductase encoding gene from Neurspora crassa was heterologously expressed in | 10-02-2008 |
| 20080241257 | Biodegradable Nanoparticles Incorporating Highly Hydrophilic Positively Charged Drugs - Nanoparticles of a biodegradable polymer containing a hydrophilic, cationic drug, like streptomycin, and preparations containing the same, are disclosed. Pharmaceutical preparations containing the nanoparticles are administered, preferably orally, to individuals suffering from a disease or condition, and the nanoparticles release the drug, in vivo, to treat the disease or condition. | 10-02-2008 |
| 20080227722 | Targeted Drug Delivery of Pain and Addiction Therapies Using Opioid Receptor-Mediated Internalization - Drug delivery is targeted to new opioid receptors using receptor-mediated internalization. Dermorphin was successfully conjugated to DSPE-PEG3400 without affecting the affinity to its receptor. The synthesized conjugate was inserted into preformed sterically stabilized liposomes to obtain dermorphin-grafted SSL. DSPE-PEG34Qo-dermorphin and dermorphin-SSL retained their affinity and selectivity for MOR. Moreover, dermorphin-SSL and encapsulated probes were taken up by CHO-hMOR cells, but not by naive CHO cells or very closely related CHO-hDOR cells. Dermorphin-SSL can be used to deliver drugs to the intracellular component of intended cells with high fidelity. Therefore, dermorphin-SSL is useful to carry pharmaceutical agents to achieve region-specific delivery of analgesics and/or to attenuate side effects associated with opioids. | 09-18-2008 |
