| The Board of Trustees of the Leland Stanford Junior University Patent applications |
| Patent application number | Title | Published |
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| 20120137394 | Atomic Force Microscope Manipulation of Living Cells - Techniques for atomic force microscope manipulation of living cells include functionalizing a nanoscale tip of a microscale cantilever with a first ligand for a first receptor associated with a surface of a first type of cell. The method further comprises, controlling the cantilever to cause the first ligand on the nanoscale tip to contact the first receptor on a surface of a living cell of the first type in a particular temporal pattern to induce a target response by the living cell. Other techniques for controlling an atomic force microscope comprising a nanoscale tip include controlling the cantilever to cause the nanoscale tip to contact a living cardiomyocyte at a predetermined pressure. The cantilever is also controlled to turn off vertical deflection feedback after contacting the cardiomyocyte and collecting deflection data that indicates a time series of nanoscale vertical deflections of the microscale cantilever caused by the living cardiomyocyte. | 05-31-2012 |
| 20120135282 | BATTERIES FOR EFFICIENT ENERGY EXTRACTION FROM A SALINITY DIFFERENCE - An electrochemical system includes: (1) a battery including an anode and a cathode; (2) a first source of a first electrolyte having a first concentration of ions; (3) a second source of a second electrolyte having a second concentration of the ions, wherein the second concentration is greater than the first concentration; and (4) a fluid conveyance mechanism connected between the battery and each of the first source and the second source. During charging of the battery, the anode and the cathode are at least partially immersed in the first electrolyte, and, during discharging of the battery, the anode and the cathode are at least partially immersed in the second electrolyte. The fluid conveyance mechanism exchanges the first electrolyte with the second electrolyte between charging and discharging of the battery, and exchanges the second electrolyte with the first electrolyte between discharging and charging of the battery. | 05-31-2012 |
| 20120130398 | SYSTEMS AND METHODS FOR TREATMENT OF DRY EYE - A stimulation system stimulates anatomical targets in a patient for treatment of dry eye. The system may include a controller and a microstimulator. The controller may be implemented externally to or internally within the microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a controller signal and apply the signal via one or more electrodes to an anatomical target. The microstimulator may not have any intelligence or logic to shape or modify a signal. The microstimulator may be a passive device configured to generate a pulse based on a signal received from the controller. The microstimulator may shape or modify a signal. Waveforms having different frequency, amplitude and period characteristics may stimulate different anatomical targets in a patient. | 05-24-2012 |
| 20120128017 | Electrical Devices Formed using Ternary Semiconducting Compounds - An electrical device includes a charge carrier transport layer formed using a ternary semiconducting compound having a stoichiometry of 1:1:1 and an element combination selected from the set of I-II-V, I-III-IV, II-II-IV, and I-I-VI; or having a stoichiometry of 3:1:2 and an element combination selected from the set of I-III-V; or having a stoichiometry of 2:1:1 and an element combination selected from the set of I-II-IV. In some embodiments, the charge carrier transport layer is used as the radiation absorption layer for a photovoltaic cell, or a light emitting layer of a light emitting device. Other devices, such as laser diode, a photodetection device, an optical modulator, a transparent electrode and a window layer, can also be formed using the ternary semiconducting compound as the charge carrier transport. | 05-24-2012 |
| 20120125430 | Solar Cell Comprising a Plasmonic Back Reflector and Method Therefor - A method for forming a solar cell having a plasmonic back reflector is disclosed. The method includes the formation of a nanoimprinted surface on which a metal electrode is conformally disposed. The surface structure of the nanoimprinted surface gives rise to a two-dimensional pattern of nanometer-scale features in the metal electrode enabling these features to collectively form the plasmonic back reflector. | 05-24-2012 |
| 20120108630 | Hedgehog Pathway Antagonists and Methods of Use - The present disclosure provides for compounds, pharmaceutical preparations, kits and methods for the inhibition of the Hh pathway and the alleviation of cancer and developmental disorders associated with the Hh pathway. | 05-03-2012 |
| 20120107240 | Probes and methods of melanoma imaging - Embodiments of the present disclosure provide for labeled probes such as a 3- | 05-03-2012 |
| 20120104589 | Deposition-free sealing for Micro- and Nano-fabrication - A method for sealing through-holes in a material via material diffusion, without the deposition of a sealant material, is disclosed. The method is well suited to the fabrication and packaging of microsystems technology-based devices and systems. In some embodiments, the method comprises forming sacrificial material release through-holes through a structural layer, removing the sacrificial material via an etch that etches the sacrificial material through the release through-holes, and sealing of the release through-holes via material diffusion. | 05-03-2012 |
| 20120104328 | Method of Selective Separation Of Semiconducting Carbon Nanotubes, Dispersion Of Semiconducting Carbon Nanotubes, And Electronic Device Including Carbon Nanotubes Separated By Using The Method - According to example embodiments, a method includes dispersing carbon nanotubes in a mixed solution containing a solvent, the carbon nanotubes, and a dispersant, the carbon nanotubes including semiconducting carbon nanotubes, the dispersant comprising a polythiophene derivative including a thiophene ring and a hydrocarbon sidechain linked to the thiophene ring. The hydrocarbon sidechain includes an alkyl group containing a carbon number of 7 or greater. The hydrocarbon sidechain may be regioregularly arranged, and the semiconducting carbon nanotubes are selectively separated from the mixed solution. An electronic device includes semiconducting carbon nanotubes and the foregoing described polythiophene derivative. | 05-03-2012 |
| 20120101283 | Prostratin and Structural or Functional Analogs Thereof - This invention concerns product and process to convert a hydroxyl group (bold in R | 04-26-2012 |
| 20120099803 | OPTICAL IMAGE PROCESSING USING MAXIMUM OR MINIMUM PHASE FUNCTIONS - A method utilizes an optical image processing system. The method includes calculating a product of (i) a measured magnitude of a Fourier transform of a complex transmission function of an object or optical image and (ii) an estimated phase term of the Fourier transform of the complex transmission function. The method further includes calculating an inverse Fourier transform of the product, wherein the inverse Fourier transform is a spatial function. The method further includes calculating an estimated complex transmission function by applying at least one constraint to the inverse Fourier transform. | 04-26-2012 |
| 20120099704 | METHOD AND SYSTEM FOR REAL-TIME DMLC-BASED TARGET TRACKING WITH OPTIMAL MOTION COMPENSATING LEAF ADAPTATION - A method of multileaf collimator (MLC) leaf positioning in tracking-based adaptive radiotherapy is provided. The method includes determining a radiotherapy beam pattern by transforming a treatment beam plan into radiotherapy beam coordinates, determining a dose discrepancy between the radiotherapy beam pattern and a deliverable MLC aperture, where the dose discrepancy includes a sum of an overdose cost and an underdose cost to a treatment volume, and minimizing the dose discrepancy, where the dose discrepancy minimization provides a determined deliverable MLC aperture for the radiotherapy beam. | 04-26-2012 |
| 20120095000 | COMPOUNDS FOR ACTIVATING TGF-BETA SIGNALING - Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-β signaling are described. | 04-19-2012 |
| 20120092009 | AUTOCALIBRATING PARALLEL IMAGING RECONSTRUCTION METHOD FROM ARBITRARY K-SPACE SAMPLING WITH REDUCED NOISE - A computer implemented method for magnetic resonance imaging is provided. A 3D Fourier Transform acquisition is performed with two phase encode directions, wherein phase code locations are chosen so that a total number of phase encodes is less than a Nyquist rate, and closest distances between phase encode locations takes on a multiplicity of values. Readout signals are received through a multi-channel array of a plurality of receivers. An autocalibrating parallel imaging interpolation is performed and a noise correlation is generated. The noise correlation is used to weight a data consistency term of a compressed sensing iterative reconstruction. An image is created from the autocalibration parallel imaging using the weighted data consistency term. The image is displayed. | 04-19-2012 |
| 20120086934 | SLOW-LIGHT FIBER BRAGG GRATING SENSOR - In certain embodiments, an optical device and a method of use is provided. The optical device can include a fiber Bragg grating and a narrowband optical source. The narrowband optical source can be configured to generate light. A first portion of light can be transmitted along a first optical path extending along and through the length of the fiber Bragg grating at a group velocity. The light can have a wavelength at or in the vicinity of a wavelength at which one or more of the following quantities is at a maximum value: (a) the product of the group index spectrum and a square root of the power transmission spectrum, (b) the slope of a product of the group index spectrum and one minus the power transmission spectrum, and (c) the slope of a product of the group index spectrum and the power transmission spectrum. | 04-12-2012 |
| 20120084022 | Enhanced Microfluidic Electromagnetic Measurements - Techniques for enhanced microfluidic impedance spectroscopy include causing a core fluid to flow into a channel between two sheath flows of one or more sheath fluids different from the core fluid. Flow in the channel is laminar. A dielectric constant of a fluid constituting either sheath flow is much less than a dielectric constant of the core fluid. Electrical impedance is measured in the channel between at least a first pair of electrodes. In some embodiments, enhanced optical measurements include causing a core fluid to flow into a channel between two sheath flows of one or more sheath fluids different from the core fluid. An optical index of refraction of a fluid constituting either sheath flow is much less than an optical index of refraction of the core fluid. An optical property is measured in the channel. | 04-05-2012 |
| 20120083826 | SURGICAL DEVICE AND METHODS - A system and method for abdominal surgery is disclosed. The system can have one or more end effectors that can be attached to an introducer and/or tray and inserted into the abdomen through a large puncture through the patient's umbilicus. The end effector can have a surgical tool, such as a grasper. The system can have a manipulatable control arm that can be inserted into the abdomen through a small puncture through the patient's body wall. The end effector can be attached to the control arm and simultaneously or concurrently detached from the introducer or tray. The control arm can then manipulate the end effector to perform the surgery. | 04-05-2012 |
| 20120078083 | RESPIRATORY MODE ("R-MODE") - ACQUISITION AND DISPLAY OF CARDIOVASCULAR IMAGES TO SHOW RESPIRATORY EFFECTS - A computer implemented method for providing cardiovascular images over a respiratory cycle through a computer system is provided. A plurality of cardiovascular images is obtained. A cardiac phase is measured for each cardiovascular image of the plurality of cardiovascular images to associate each cardiovascular image to a cardiac phase. A respiratory phase is measured for each cardiovascular image of the plurality of cardiovascular images to associate each cardiovascular image to a respiratory phase. A first group of cardiovascular images with an associated first cardiac phase of the plurality of cardiovascular images is sorted in order of respiratory phases. The first group of cardiovascular images with the associated first cardiac phase of the plurality of cardiovascular images is displayed in order of respiratory phases. | 03-29-2012 |
| 20120077204 | Detection of Protein Translocation by Beta-Galactosidase Reporter Fragment Complementation - Methods and compositions are provided for detecting molecular translocations, particularly protein translocations within and between sub-cellular compartments, using at least two components that exhibit a localization-dependent difference in complementation activity. In particular, alpha-complementing β-galactosidase fragments are provided. These β-galactosidase reporter fragments display significantly enhanced enzymatic activity when one fragment is localized in a membrane. Methods for carrying out no-wash ELISA assays based on the reporter component system are also provided. | 03-29-2012 |
| 20120069346 | METHOD OF USING A UNIDIRECTIONAL CROW GYROSCOPE - A method for detecting rotation includes providing a plurality of resonant waveguides generally adjacent to one another and optically coupled to one another. Each resonant waveguide of the plurality of resonant waveguides is configured to allow light to propagate along the resonant waveguide in a planar path. The method further includes propagating light along each path in a clockwise direction or along each path in a counterclockwise direction. | 03-22-2012 |
| 20120066783 | AAV CAPSID LIBRARY AND AAV CAPSID PROTEINS - Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided. | 03-15-2012 |
| 20120062902 | FIBER OPTIC SENSOR USING A HOLLOW CORE FIBER - An optical sensor includes at least a portion of an optical waveguide having a hollow core generally surrounded by a cladding. The cladding substantially confines a first optical signal and a second optical signal within the hollow core as the first optical signal and the second optical signal counterpropagate through the optical waveguide. Interference between the first optical signal and the second optical signal is responsive to perturbation of the at least a portion of the optical waveguide. | 03-15-2012 |
| 20120059394 | CLOSURE DEVICE AND METHOD - Devices and methods for treatment of prolapsed hemorrhoidal arteries is disclosed. The devices can identify the hemorrhoid and ligate the artery without causing significant pain or distension of the rectum. The artery can be identified with ultrasound. The ligation can be performed using energy and/or mechanical structures, such as clips or rubber bands. | 03-08-2012 |
| 20120046591 | TREATMENT DEVICES AND METHODS WITH EXTENDING ELEMENTS - Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress. | 02-23-2012 |
| 20120046586 | SKIN TREATMENT DEVICES AND METHODS WITH PRE-STRESSED CONFIGURATIONS - Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress. | 02-23-2012 |
| 20120045828 | Apparatus for Magnetic Separation of Cells - Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput. | 02-23-2012 |
| 20120039846 | HEPATITIS C ANTIBODIES AND USES THEREOF - The present invention provides identification and characterization of conformational epitopes of the envelope protein E2 of the Hepatitis C virus (HCV). The present invention provides a panel of human monoclonal antibodies that recognize conformational epitopes of E2. The antibodies are derived from patients infected with HCV. The present invention provides methods for utilizing HCV antibodies as therapeutic, diagnostic, and/or prophylactic agents. The present invention provides mimotopes with conformational epitopes intact and methods of using mimotopes. The present invention provides methods of stratifying patients based on their response to HCV. The present invention provides pharmaceutical compositions for prevention and treatment of HCV comprising one or more HCV antibodies. | 02-16-2012 |
| 20120029466 | DRAINAGE DEVICES AND METHODS FOR USE - Devices and methods for draining excess lymph fluid are disclosed. The device can be fixed to the blood vessel adjacent to the thoracic duct. The device can have a port for withdrawing lymph fluid exiting the thoracic duct. The device can have a cannula and/or subcutaneous port to draw the lymph fluid away from the thoracic duct and reduce hemostatic pressure in the lymphatic system. | 02-02-2012 |
| 20120021414 | DIAGNOSTIC MARKERS OF IMMUNOSENESCENCE AND METHODS OF USE THEREOF - Embodiments of the present invention provide diagnostic markers of immunosenescence and methods of identifying individuals with impaired immune function based on a combination of such markers obtained from various analyses, primarily from blood, testing immune function including the analysis of immune cell subset frequencies, gene expression, cytokine and chemokine levels, and signaling responses to stimulation with cytokines (‘cytokine response’). Particular combinations of markers can predict with high accuracy whether an individual will respond to active vaccination and become protected against recurring diseases. | 01-26-2012 |
| 20120019712 | IMAGING ARRANGEMENTS AND METHODS THEREFOR - Image data is processed to facilitate focusing and/or optical correction. According to an example embodiment of the present invention, an imaging arrangement collects light data corresponding to light passing through a particular focal plane. The light data is collected using an approach that facilitates the determination of the direction from which various portions of the light incident upon a portion of the focal plane emanate from. Using this directional information in connection with value of the light as detected by photosensors, an image represented by the light is selectively focused and/or corrected. | 01-26-2012 |
| 20120016325 | REDUCED PRESSURE THERAPY DEVICES - Described generally herein are tissue therapy devices, which may comprise a sealant layer and a suction apparatus. The sealant layer functions so as to create a sealed enclosure between it and the surface of a patient by forming, preferably, an airtight seal around an area of tissue that requires negative pressure therapy. The tissue therapy device may comprise a suction apparatus. The suction apparatus is typically in fluid communication with the sealant layer and functions so as to reduce the amount of pressure present underneath the sealant layer. The reduced pressure is self-created by the suction apparatus. Together the sealant layer and the suction apparatus preferably create a closed reduced pressure therapy system. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of the air molecules under the sealant layer. | 01-19-2012 |
| 20120004279 | COMPOSITIONS AND METHODS FOR MODULATING ACTIVITY OF CAPPED SMALL RNAS - Compositions and methods for modulating transcription by RNA polymerases are described. | 01-05-2012 |
| 20120004278 | LINC RNAS IN CANCER DIAGNOSIS AND TREATMENT - Long non-coding RNAs (lincRNAs), a relatively recently recognized class of widely transcribed genes, are thought to affect chromatin state and epigenetic regulation, but their mechanisms of action and potential roles in human disease are poorly understood. The present invention shows that long non-coding RNAs in the human HOX loci are systematically dysregulated during breast cancer progression, and that expression levels of the lincRNA termed HOTAIR can predict cancer metastasis. Elevated levels of HOTAIR can lead to altered patterns of Polycomb binding to the genome. These findings indicate that lincRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy. | 01-05-2012 |
| 20110319405 | Treatment and prevention of diffuse parenchymal lung disease by selective active-site mTOR inhibitors - Embodiments are related to new uses for selective active-site mTOR inhibitors in treating or preventing pulmonary fibrosis in diffuse parenchymal lung disease (DPLD) patients, such as a DPLD of environmental cause, a collagen vascular disease (e.g., scleroderma and rheumatoid arthritis), an idiopathic interstitial pneumonia (e.g., idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia), and sarcoidosis. | 12-29-2011 |
| 20110319272 | Noninvasive Diagnosis of Fetal Aneuploidy by Sequencing - Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated. By counting the number of sequence tags mapped to a predefined window in each chromosome, the over- or under-representation of any chromosome in maternal plasma DNA contributed by an aneuploid fetus can be detected. This method does not require the differentiation of fetal versus maternal DNA. The median count of autosomal values is used as a normalization constant to account for differences in total number of sequence tags is used for comparison between samples and between chromosomes. | 12-29-2011 |
| 20110317167 | APPARATUS FOR MEASURING A FREQUENCY-DOMAIN OPTICAL COHERENCE TOMOGRAPHY POWER SPECTRUM FROM A SAMPLE - An apparatus is provided for measuring a frequency-domain optical coherence tomography power spectrum from a sample. The apparatus includes a partially reflective element configured to be optically coupled to a light source and to the sample. A first portion of light from the light source is configured to be reflected by the partially reflective element. A second portion of light from the light source is configured to propagate through the partially reflective element, to impinge the sample, and to reflect from the sample. The apparatus is configured to receive the first and second portions of light and to measure the frequency-domain optical coherence tomography power spectrum in response to the first portion of light and the second portion of light. | 12-29-2011 |
| 20110312518 | MICROFLUIDIC DEVICES FOR MEASUREMENT OR DETECTION INVOLVING CELLS OR BIOMOLECULES - Embodiments of the invention are related to microfluidic devices for detecting or determining the concentration of biomolecules in an analyte comprising: a channel, wherein a surface of said channel is fabricated to be functionalized with at least one molecule selected to interact with a biomolecule, said channel being configured to interact with a microsphere, wherein a surface of said microsphere is fabricated to be functionalized with at least one same or different molecule selected to interact with said biomolecule; a second channel in fluid communication with said first channel; a system to move fluid containing said microsphere through said first and second channels; and a system to measure a change in electrical impedance or optical microscopy across said second channel as said microsphere moves through said second channel. Other embodiments concern related devices, and methods of making and using. | 12-22-2011 |
| 20110301431 | Methods of classifying cognitive states and traits and applications thereof - The present invention provides for improved brain imaging and decoding methods that test subjects under authentic, natural conditions that allow for regular patterns of free-flowing thought and perception, as they occur in everyday life, while taking into account brain activities that were measured over spatially diverse regions of the whole-brain (whole-brain connectivity signatures). From such whole-brain connectivity signatures, specific cognitive traits and states are decoded and classified in a whole-brain connectivity analysis which takes into account the full pattern of brain activity. Such methods find applications in clinical diagnosis and monitoring of neuropsychiatric diseases and in nonclinical areas such as neuromarketing and neuroeconomics. | 12-08-2011 |
| 20110300154 | TREATMENT OF AIRWAY HYPERREACTIVITY - The invention provides strategies for treating and preventing airway hyperreactivity and non-allergic asthma comprising antagonizing IL-17 activity and/or production by iNKT cells. Provided herein is a method of diagnosing non-allergic asthma and airway hyperreactivity comprising neutrophils quantification in sputum. | 12-08-2011 |
| 20110298397 | Special purpose modes in photonic band gap fibers - Photonic band gap fibers are described having one or more defects suitable for the acceleration of electrons or other charged particles. Methods and devices are described for exciting special purpose modes in the defects including laser coupling schemes as well as various fiber designs and components for facilitating excitation of desired modes. Results are also presented showing effects on modes due to modes in other defects within the fiber and due to the proximity of defects to the fiber edge. Techniques and devices are described for controlling electrons within the defect(s). Various applications for electrons or other energetic charged particles produced by such photonic band gap fibers are also described. | 12-08-2011 |
| 20110293709 | PEPTIDE TYROSINASE INHIBITORS AND USES THEREOF - Disclosed are peptides which inhibit the enzymatic activity of tyrosinase as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory peptides in a topical formulation. Methods of skin treatment are also provided, the methods further including use of a peptide characterized by the amino acid sequence SFLLRN (SEQ ID NO: 1). | 12-01-2011 |
| 20110281932 | Methods to enhance T-cell mediated immune response - The present invention provides methods for restoring or enhancing T cell mediated immune response in individuals of middle and advanced age. | 11-17-2011 |
| 20110281739 | Charge Perturbation Detection System for DNA and Other Molecules - Methods and apparatus for direct detection of chemical reactions are provided. In a preferred embodiment, electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The target molecule is preferably DNA. The charge perturbation caused by the polymerase reaction can uniquely identify a DNA sequence. The polymerization process generates local perturbations of charge in the solution near the electrode surface and induces a charge in a polarazible gold electrode. This event is detected as a transient current by a voltage clamp amplifier. Detection of single nucleotides in a sequence can be determined by dispensing individual dNTPs to the electrode solution and detecting the charge perturbations. Alternatively, multiple bases can be determined at the same time using a mix of all dNTPs with subsequent analysis of the resulting signal. The initial enzyme attachment to the DNA molecule can be detected prior to polymerization, with electrode capacitance measurement using the same voltage-clamp amplifier. This technique and device may be adapted to other reaction determinations, such as enzymatic reactions, other electrode configurations, and other amplifying circuits. | 11-17-2011 |
| 20110281365 | PROTEIN-BASED ASSAYS FOR SCREENING OF THE IGE-RECEPTOR INTERACTION - Embodiments of the invention are related to a polypeptide comprising the amino acid sequence of a human IgE-Fc Cε3-Cε4, wherein said Cε3-Cε4 starts at amino acid 328 and ends at amino acid 547 of said IgE-Fc, and wherein C 328 is A and K 367 is C. Other embodiments concern a second polypeptide comprising the amino acid sequence of a human FcεRIα extracellular region, wherein said extracellular region starts at amino acid 1 and ends at amino acid 176 of said FcεRIα. Still other embodiments are related to a method of identifying a compound that inhibits the binding of an IgE-Fc to a FcεRIα, said method comprising: contacting the polypeptide, wherein said IgE-Fc Cε3-Cε4 sequence is labeled with a fluorophore, and the second polypeptide, with a test compound; and determining whether binding of said polypeptide to said second polypeptide is decreased in the presence of said test compound. | 11-17-2011 |
| 20110280804 | HIGHLY SELECTIVE SIGMA RECEPTOR RADIOLIGANDS - Compounds having the general formula III′, or IV′ | 11-17-2011 |
| 20110278554 | Hybrid quantum dot/protein nanostructure, methods of making, and methods of use thereof - Embodiments of the present disclosure include hybrid quantum dot/protein nanostructure, hybrid quantum dot/protein nanostructure systems, methods of using hybrid quantum dot/protein nanostructures, and the like. | 11-17-2011 |
| 20110277050 | SYSTEM AND METHODS TO CONTROL TRANSGENE EXPRESSION - Embodiments of the present invention describe a novel and versatile inducible binary expression system (the ‘Q system’) and methods for controlling transgene expression in vitro and in vivo, for lineage tracing, for genetic mosaic analysis and for determining gene function. | 11-10-2011 |
| 20110274155 | APPARATUS, SYSTEM, AND METHOD FOR DISTRIBUTED VIDEO TRANSCODING - A method is described for streaming video data within a network, wherein the video data includes a sequence of frames. The method includes encoding the sequence of frames and generating a plurality of substreams from the encoded frames in this embodiment. Each of the plurality of substreams is assigned an identifier, and each substream includes a common encoded frame and a non-overlapping portion of the encoded sequence. The non-overlapping portion of the encoded sequence of each substream is selected from the encoded frames based on the identifier of the respective substream. The method also includes transmitting the plurality of substreams to a receiver in an embodiment. | 11-10-2011 |
| 20110273712 | APPARATUS AND METHODS USING HOLLOW-CORE FIBER TAPERS - An optical device and methods of using an optical device are provided. The optical device includes a hollow-core fiber including a first portion and a second portion. The first portion includes a hollow core having a first diameter. The second portion includes a hollow core having a second diameter smaller than the first diameter. The difference between the first diameter and the second diameter is less than 10% of the first diameter. | 11-10-2011 |
| 20110268384 | OPTICAL-FIBER-COMPATIBLE ACOUSTIC SENSOR - An acoustic sensor includes a diaphragm having a reflective element. The sensor has an optical fiber positioned relative to the reflective element such that light emitted from the optical fiber is reflected by the reflective element. A first end of the optical fiber and the reflective element form an optical cavity therebetween. The acoustic sensor further includes a structural element mechanically coupled to the diaphragm and the optical fiber. The structural element includes a material having a coefficient of thermal expansion substantially similar to the coefficient of thermal expansion of the optical fiber. For example, the material can be silica. | 11-03-2011 |
| 20110259747 | WATER STERILIZATION DEVICES INCLUDING NANOSTRUCTURES AND USES THEREOF - A water sterilization device includes: (1) a conduit including an inlet to provide entry of untreated water and an outlet to provide exit of treated water; (2) a porous electrode housed in the conduit and disposed between the inlet and the outlet, the porous electrode including a porous support and nanostructures coupled to the porous support; and (3) an electrical source coupled to the porous electrode. | 10-27-2011 |
| 20110257245 | METHODS OF IDENTIFYING REGULATORS OF CELLULAR PROTEOSTASIS - Embodiments of the present invention provide methods for identifying and utilizing regulators of cellular proteostasis as new therapeutic targets against protein misfolding diseases. | 10-20-2011 |
| 20110253969 | Narrow Graphene Nanoribbons from Carbon Nanotubes - Disclosed is a method for making graphene nanoribbons (GNRs) by controlled unzipping of structures such as carbon nanotubes (CNTs) by etching (e.g., argon plasma etching) of nanotubes partly embedded in a polymer film. The GNRs have smooth edges and a narrow width distribution (2-20 nm). Raman spectroscopy and electrical transport measurements reveal the high quality of the GNRs. Such a method of unzipping CNTs with well-defined structures in an array will allow the production of GNRs with controlled widths, edge structures, placement and alignment in a scalable fashion for device integration. GNRs may be formed from nanostructures in a controlled array to form arrays of parallel or overlapping structures. Also disclosed is a method in which the CNTs are in a predetermined pattern that is carried over and transferred to a substrate for forming into a semiconductor device. | 10-20-2011 |
| 20110246083 | Noninvasive Diagnosis of Fetal Aneuploidy by Sequencing - Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated. By counting the number of sequence tags mapped to a predefined window in each chromosome, the over- or under-representation of any chromosome in maternal plasma DNA contributed by an aneuploid fetus can be detected. This method does not require the differentiation of fetal versus maternal DNA. The median count of autosomal values is used as a normalization constant to account for differences in total number of sequence tags is used for comparison between samples and between chromosomes. | 10-06-2011 |
| 20110244692 | Method for Forming a Nano-textured Substrate - A method for forming a nano-textured surface on a substrate is disclosed. An illustrative embodiment of the present invention comprises dispensing of a nanoparticle ink of nanoparticles and solvent onto the surface of a substrate, distributing the ink to form substantially uniform, liquid nascent layer of the ink, and enabling the solvent to evaporate from the nanoparticle ink thereby inducing the nanoparticles to assemble into an texture layer. Methods in accordance with the present invention enable rapid formation of large-area substrates having a nano-textured surface. Embodiments of the present invention are well suited for texturing substrates using high-speed, large scale, roll-to-roll coating equipment, such as that used in office product, film coating, and flexible packaging applications. Further, embodiments of the present invention are well suited for use with rigid or flexible substrates. | 10-06-2011 |
| 20110244661 | Large Scale High Quality Graphene Nanoribbons From Unzipped Carbon Nanotubes - A new method is disclosed for large-scale production of pristine few-layer graphene nanoribbons (GNRs) through unzipping of mildly gas-phase oxidized, and, optionally, metal-assisted oxidized, multiwalled and few-walled carbon nanotubes. The method further comprises sonication in an organic solvent. High-resolution transmission electron microscopy revealed nearly atomically smooth edges for narrow GNRs (2-30 nm). The GNRs exhibit ultra-high quality with low ratios of disorder (D) to graphitic (G) Raman bands (I | 10-06-2011 |
| 20110243848 | STAR POLYMERS, METHODS OF PREPARATION THEREOF, AND USES THEREOF - A composition of matter comprising an amphiphilic star polymer, the star polymer comprising a crosslinked microgel core and 6 or more independent polymer arms covalently linked to the core, the 6 or more arms each comprising a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; wherein each individual metal selected from the group consisting of beryllium, magnesium, calcium, strontium, barium, radium, aluminum, gallium, indium, thallium, germanium, tin, lead, arsenic, antimony, bismuth, tellurium, polonium, and metals of Groups 3 to 12 of the Periodic Table has a concentration in the star polymer of greater than or equal to 0 parts per million and less than or equal to 100 parts per million. | 10-06-2011 |
| 20110230760 | Raman imaging devices and methods of molecular imaging - In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to Raman imaging devices (e.g., Raman endoscope probes), methods of using Raman agents and Raman imaging devices to image or detect a signal, and the like. | 09-22-2011 |
| 20110229955 | LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME - Briefly described, embodiments of this disclosure include polynucleotides that encode mutant | 09-22-2011 |
| 20110229952 | METHOD AND APPARATUS FOR AVALANCHE-MEDIATED TRANSFER OF AGENTS INTO CELLS - The present invention provides a method and apparatus for transferring an agent into a cell. The method includes the steps of providing an agent outside of a cell and generating a vapor bubble and a plasma discharge between an avalanche electrode and a conductive fluid surrounding the cell. The vapor bubble and plasma discharge generate a mechanical stress wave and an electric field, respectively. The combination of this mechanical stress wave and electric field results in permeabilization of the cell, which in turn results in transfer of the agent into the cell. | 09-22-2011 |
| 20110224491 | DEVICE AND METHOD FOR DEPLOYING CAP ON ENDOSCOPE - A system is disclosed for assisting in endoscopic procedures. The method comprises a cap and a device for deploying a cap on the endoscope while the endoscope is positioned within a body lumen. A method of deploying a cap on an endoscope during an endoscopic procedure is disclosed. The method comprises providing a cap and a device for deploying the cap on the endoscope while the endoscope is positioned with a body lumen, advancing the endoscopic within a body lumen and deploying the cap on the endoscope. | 09-15-2011 |
| 20110224144 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING MENTAL DISORDERS - The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders. | 09-15-2011 |
| 20110213567 | Method for Rapidly Approximating Similarities - Methods and algorithms are presented that implement linear algebraic techniques for rapidly estimating chemical similarities for several popular measures. The methods of the present invention reflect source similarity measures for both Tanimoto calculation and rank ordering. After a precalculation step on a database, the methods of the present invention afford several orders of magnitude of speedup in database screening. The present invention also provides an asymptotic speedup for large similarity matrix construction problems, reducing the number of conventional slow similarity evaluations required from quadratic to linear scaling. | 09-01-2011 |
| 20110212854 | METHODS AND COMPOSITIONS FOR DIAGNOSIS, STRATIFICATION, AND MONITORING OF ALZHEIMER'S DISEASE AND OTHER NEUROLOGICAL DISORDERS IN BODY FLUIDS - The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels. | 09-01-2011 |
| 20110204241 | METHODS AND SYSTEMS FOR RADIATION DETECTION - An apparatus for detecting ionizing radiation from a source. A detector is disposed relative to the source to receive the ionizing radiation. The ionizing radiation causes ionization and/or excitation in the detector, wherein an optical property of the detector is altered in response to the ionization and/or excitation. A source of coherent probing light is disposed relative to the detector to probe the detector. The detector outputs the probing light, wherein the output light is modulated in response to the altered optical property. A receiver receives the output light and detects modulation in the output light. | 08-25-2011 |
| 20110201107 | Multimodality imaging of reporter gene expression using a novel fusion vector in living cells and animals - Novel double and triple fusion reporter gene constructs harboring distinct imagable reporter genes are provided, as well as applications for the use of such double and triple fusion constructs in living cells and in living animals using distinct imaging technologies. | 08-18-2011 |
| 20110198499 | Near-infrared photodetectors, image sensors employing the same, and methods of manufacturing the same - Silicon photodetectors using near-infrared dipole antennas. The photodetectors include a silicon region formed on a semiconductor substrate, dipole antenna forming two arms that are spaced apart with the silicon region therebetween and inducing an electromagnetic wave signal of incident light, and electrodes disposed in a vertical direction of the dipole antenna and spaced apart with the silicon region therebetween, where a critical bias voltage is applied to the electrodes to induce an avalanche gain operation in the silicon region. | 08-18-2011 |
| 20110184196 | Preparation of azide-modified carbon surfaces for coupling to various species - The invention relates to carbon surfaces modified with one or more azide groups. The invention also relates to methods of modifying carbon surfaces with one or more azide groups. | 07-28-2011 |
| 20110182797 | Nitrogen-Permeable Membranes and Uses Thereof - A nitrogen-permeable structure includes a porous support and a nitrogen-permeable membrane adjacent to the porous support. The nitrogen-permeable membrane includes a first metal and a second metal, wherein the first metal is selected from niobium, tantalum, and vanadium, and the second metal is different from the first metal. | 07-28-2011 |
| 20110177090 | Glycan markers and autoantibody signatures in HIV-1 and HIV-1-associated malignancies - The present invention provides compositions and methods for the specific and sensitive detection and characterization of anti-carbohydrate antibodies against immunogenic sugar moieties on microbes and abnormal cells and anti-HIV-1 protein antibodies for the development of diagnostic, prophylactic and therapeutic strategies against diseases inflicted by cancer cells or microbial pathogens. | 07-21-2011 |
| 20110176140 | LOW-NOISE FIBER-OPTIC SENSOR UTILIZING A LASER SOURCE - A fiber-optic sensor includes an optical fiber coil and a laser source optically coupled to the coil. Light from the source is transmitted to the coil as a first optical signal and a second optical signal counter-propagating through the coil. The optical paths of the first optical signal and the second optical signal are substantially reciprocal with one another and the first optical signal and the second optical signal are combined together after counter-propagating through the coil to generate a third optical signal. The laser source is frequency-modulated or can have a coherence length longer than a length of the coil. | 07-21-2011 |
| 20110171655 | PH MEASUREMENT FOR SEQUENCING OF DNA - The present method involves sequencing by synthesis in which a template strand having an attached primer is immobilized in a small volume reaction mixture. In one embodiment, the reaction mixture is in contact with a sensitive heat sensor, which detects the heat of reaction from incorporation of a complementary base (dNTP) in the presence of appropriate reagents (DNA polymerase, and polymerase reaction buffer). Alternatively, or in addition, a change in pH resulting from the incorporation of nucleotides in the DNA polymerase reaction is measured. A device is provided having delivery channels for appropriate reagents, including dNTPs, which may be delivered sequentially or in a mixture. Preferably, the dNTPs are added in a predetermined sequence, and the dNTP is incorporated or not depending on the template sequence. | 07-14-2011 |
| 20110151442 | Direct Molecular Diagnosis of Fetal Aneuploidy - Methods and materials for detection of aneuploidy and other chromosomal abnormalities using fetal tissue are disclosed. Results can be obtained rapidly, without cell culture. The method uses digital PCR for amplification and detection of single target sequences, allowing an accurate count of a specific chromosome or chromosomal region. Specific polynucleic acid primers and probes are disclosed for chromosomes 1, 13, 18, 21, X and Y. These polynucleic acid sequences are chosen to be essentially invariant between individuals, so the test is not dependent on sequence differences between fetus and mother. | 06-23-2011 |
| 20110144034 | INHIBITION OF TUMOR METASTASES USING PROTEIN KINASE C (PKC) INHIBITORS - Described are methods for reducing tumor metastasis in an animal by administering an inhibitor of a protein kinase C (PKC) isozyme. | 06-16-2011 |
| 20110143991 | Peptides for Activation and Inhibition of Delta-PKC - Peptides able to inhibit or activate the translocation or function of δPKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for δPKC-selective agonists and antagonists. | 06-16-2011 |
| 20110142397 | MULTIPLE-CORE OPTICAL FIBER WITH COUPLINGS BETWEEN THE CORES - An optical fiber includes a cladding, a first core, and a second core. At least one of the first core and the second core is hollow and is substantially surrounded by the cladding. At least a portion of the first core is generally parallel to and spaced from at least a portion of the second core. The optical fiber includes a defect substantially surrounded by the cladding, the defect increasing a coupling coefficient between the first core and the second core. | 06-16-2011 |
| 20110136740 | CYSTINE KNOT PEPTIDES BINDING TO ALPHA IIb BETA 3 INTEGRINS AND METHODS OF USE - Disclosed are peptides having a cystine knot structural motif and comprising a sequence engineered for specificity against α | 06-09-2011 |
| 20110125009 | Assessing the Condition of a Joint and Devising Treatment - Methods are disclosed for assessing the condition of a cartilage in a joint, particularly in a human knee. The methods include converting an image such as an MRI to a three dimensional map of the cartilage. The cartilage map can be correlated to a movement pattern of the joint to assess the affect of movement on cartilage wear. Changes in the thickness of cartilage over time can be determined so that therapies can be provided. Information on thickness of cartilage and curvature of cartilage or subchondral bone can be used to plan therapy. Information on movement pattern can be used to plan therapy. | 05-26-2011 |
| 20110124707 | Methods And Compositions For Reducing Viral Genome Amounts In A Target Cell - Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition. | 05-26-2011 |
| 20110124529 | Apparatus and Method for Polymer Synthesis Using Arrays - A polymer synthesis apparatus ( | 05-26-2011 |
| 20110121431 | Substrate Comprising a Nanometer-scale Projection Array - A method for forming a substrate comprising nanometer-scale pillars or cones that project from the surface of the substrate is disclosed. The method enables control over physical characteristics of the projections including diameter, sidewall angle, and tip shape. The method further enables control over the arrangement of the projections including characteristics such as center-to-center spacing and separation distance. | 05-26-2011 |
| 20110121409 | Field effect transistors, methods of fabricating a carbon-insulating layer using molecular beam epitaxy and methods of fabricating a field effect transistor - Field effect transistors, methods of fabricating a carbon insulating layer using molecular beam epitaxy and methods of fabricating a field effect transistor using the same are provided, the methods of fabricating the carbon insulating layer include maintaining a substrate disposed in a molecular beam epitaxy chamber at a temperature in a range of about 300° C. to about 500° C. and maintaining the chamber in vacuum of 10 | 05-26-2011 |
| 20110117100 | COMPOSITIONS AND METHODS FOR DIAGNOSIS, STRATIFICATION AND TREATMENT OF AMYLOIDOGENIC DISEASES - Natural human autoantibodies against toxic assemblies of Aβ and related peptide species offer a unique immune repertoire. Based on this repertoire, the present invention provides compositions and methods for diagnosis as well as for prophylactic and therapeutic treatment of neurodegenerative diseases such as Alzheimer's disease that are characterized by accumulation of beta-amyloid deposits. The same human autoantibodies may be useful for prophylactic and therapeutic treatment of other neurodegenerative disorders and systemic pathological conditions that are due to or are associated with toxic assemblies of other amyloidogenic peptides or proteins. | 05-19-2011 |
| 20110112034 | Modulation of synaptogenesis - Soluble proteins, e.g. thrombospondins, can trigger synapse formation. Such proteins are synthesized in vitro and in vivo by astrocytes, which therefore have a role in synaptogenesis. These thrombospondins are only expressed in the normal brain exactly during the period of developmental synaptogenesis, being off in embryonic brain and adult brain but on at high levels in postnatal brain. Methods are provided for protecting or treating an individual suffering from adverse effects of deficits in synaptogenesis, or from undesirably active synaptogenesis. These findings have broad implications for a variety of clinical conditions, including traumatic brain injury, epilepsy, and other conditions where synapses fail to form or form inappropriately. Synaptogenesis is enhanced by contacting neurons with agents that are specific agonists or antagonists of thrombospondins. Conversely, synaptogenesis is inhibited by contacting neurons with inhibitors or antagonists of thrombospondins. | 05-12-2011 |
| 20110106160 | SYSTEMS AND METHODS FOR POSTERIOR DYNAMIC STABILIZATION OF THE SPINE - Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer having an undeployed configuration and a deployed configuration, wherein the spacer has axial and radial dimensions for positioning between the spinous processes of adjacent vertebrae. The systems include one or more spacers and a mechanical actuation means for delivering and deploying the spacer. The methods involve the implantation of one or more spacers within the interspinous space. | 05-05-2011 |
| 20110105834 | IMAGING AND EVALUATING EMBRYOS, OOCYTES, AND STEM CELLS - Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 05-05-2011 |
| 20110105436 | HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE IN CANCER TREATMENT - Provided herein are novel heteroaryl compounds, compositions comprising the compounds, and methods of treatment or prevention comprising administration of the compounds. The compounds are effective in the targeting of cells defective in the von Hippel-Lindau gene and in inducing autophagic cell death. The methods are directed to treating or preventing diseases such as cancer, and in particular cancers resulting from von Hippel-Lindau disease. The compounds of the invention may be administered in combination with another therapeutic agent. | 05-05-2011 |
| 20110104674 | SNP DETECTION AND OTHER METHODS FOR CHARACTERIZING AND TREATING BIPOLAR DISORDER AND OTHER AILMENTS - The present application relates to the use of SNPs and differential exon expression to characterize, diagnose or treat bipolar disorder and other mental illnesses, such as major depressive disorder and schizophrenia. | 05-05-2011 |
| 20110104181 | MODULATION OF SYNAPTOGENESIS - The present invention describes methods and compositions for modulating synaptogenesis and axon and/or dendritic growth. The methods include the use of agents that modulate a thrombospondin and/or an α2δ subunit of a calcium channel. | 05-05-2011 |
| 20110097267 | COMPOSITIONS FOR IMAGING PAIN AND STRESS IN VIVO - Briefly described, embodiments of the present disclosure relate to methods and compositions for imaging pain and/or stress in a subject and methods and compositions for treating associated conditions. In particular, the present disclosure relates to the use of labeled compounds to provide objective diagnosis of pain and/or stress, for imaging regions associated with pain and/or stress, and for treating pain in a subject. | 04-28-2011 |
| 20110095389 | Optoelectronic Semiconductor Device and Method of Fabrication - An optoelectronic device comprising an optically active layer that includes a plurality of domes is presented. The plurality of domes is arrayed in two dimensions having a periodicity in each dimension that is less than or comparable with the shortest wavelength in a spectral range of interest. By virtue of the plurality of domes, the optoelectronic device achieves high performance. A solar cell having high energy-conversion efficiency, improved absorption over the spectral range of interest, and an improved acceptance angle is presented as an exemplary device. | 04-28-2011 |
| 20110092762 | IMAGING AND EVALUATING EMBRYOS, OOCYTES, AND STEM CELLS - Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 04-21-2011 |
| 20110092433 | FGF9-RELATED METHODS FOR TREATING ANXIETY - The present application relates to the treatment of anxiety in a subject. The invention provides novel diagnostic markers and assays, as well as agents and compounds useful for treating patients who suffer from mental illnesses and anxiety disorders. | 04-21-2011 |
| 20110091530 | OLIGOPEPTIDE TYROSINASE INHIBITORS AND USES THEREOF - Disclosed are peptides that inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory peptides in a topical formulation. Peptide sequences disclosed include KFEKKFEK (SEQ ID NO: 1) and YRSRKYSSWY (SEQ ID NO: 2). | 04-21-2011 |
| 20110088470 | METHOD USING ASYMMETRIC OPTICAL RESONANCES - A method utilizes an optical resonator that includes a reflective element and a spatial mode filter positioned relative to the reflective element such that light emitted from the spatial mode filter is reflected by the reflective element. The optical resonator has an optical resonance with a resonance lineshape that is asymmetric as a function of wavelength. | 04-21-2011 |
| 20110088457 | COMPOSITIONS, SYSTEMS AND METHODS FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF DISORDERS ASSOCIATED WITH AZETIDINE-2-CARBOXYLIC ACID - Methods and systems for detecting azetidine-2-carboxylic acid (Aze) in food consumable by humans and animals are provided. Also provided are methods and systems for inactivating Aze in food and byproducts, as well as other methods for the diagnosis, prevention, and treatment of disorders associated with Aze. | 04-21-2011 |
| 20110086393 | METHOD TO PRODUCE SINGLE STRANDED DNA OF DEFINED LENGTH AND SEQUENCE AND DNA PROBES PRODUCED THEREBY - A method for producing a single stranded DNA (ssDNA) molecule of a defined length and sequence is disclosed. This method enables the preparation of, inter alia, probes of greater length than can be chemically synthesized. The method starts with a double stranded molecule, such as genomic, double stranded DNA (dsDNA) from any organism. A fragment of the starting molecule (dsDNA) is amplified by specific primers engineered to introduce cleavage sites on either side of the desired sequence. Cleavage steps on the amplified, engineered fragment are combined with a phosphate removal step, thereby creating a construct that can be digested with an exonuclease without damage to the desired ssDNA. Probes, which hybridize with large gaps between the ends of the probes, are also disclosed. | 04-14-2011 |
| 20110085980 | CELL CYCLE REGULATION AND DIFFERENTIATION - The present invention provides compositions and methods for regulating neural cell proliferation or differentiation. The present invention also provides methods for selecting for bioactive agents effective in regulating proliferation or differentiation. | 04-14-2011 |
| 20110082085 | PEPTIDES DERIVED FROM THE C2 DOMAIN OF EPSILON PKC AND METHODS OF USE, THEREOF - Peptides derived from the C2 regions of εPKC and methods of use, thereof, are described. These peptides modulate the activity of εPKC in an animal model of acute ischemic heart disease. | 04-07-2011 |
| 20110041616 | ACOUSTIC SENSOR WITH AT LEAST ONE PHOTONIC CRYSTAL SLAB - An acoustic sensor includes at least one structure including at least one photonic crystal slab and an optical fiber optically coupled to the at least one photonic crystal slab, and having at least one optical resonance with a resonance frequency and a resonance lineshape. The acoustic sensor further includes a housing mechanically coupled to the at least one structure. At least one of the resonance frequency and the resonance lineshape is responsive to acoustic waves incident upon the housing. | 02-24-2011 |
| 20110034543 | DNA Vaccination For Treatment of Multiple Sclerosis and Insulin-Dependent Diabetes Mellitus - A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further treating by co-vaccination with a DNA encoding a Th2 cytokine, particularly encoding IL4. In response to the vaccination, the proliferation of autoantigen-reactive T cells and the secretion of Th1 cytokines, including IL-2, IFN-γ and IL-15, are reduced. | 02-10-2011 |
| 20110028833 | METHODS AND APPARATUSES FOR ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY - A method is disclosed for distending a body lumen in the performance of endoscopic retrograde cholangiopancreatography (ERCP). The method comprises insufflating the body lumen with contrast agent to distend the body lumen. The contrast agent includes gas. | 02-03-2011 |
| 20110002573 | OPTICAL ISOLATION CREATED BY INDIRECT INTERBAND PHOTONIC TRANSITIONS - The refractive index of the at least one photonic structure having two separate photonic bands is modulated, so that light supplied to the at least one photonic structure and initially in one of the two photonic bands of the traveling along a forward direction in the at least one photonic structure is converted to light in a second one of the photonic bands, and light in the one photonic band traveling along a backward direction opposite to the forward direction in the at least one photonic structure is not converted and remains in the one photonic band, achieving non-reciprocity. An interferometer comprises a first and a second photonic structure coupled at two coupler regions. The first photonic structure has two separate photonic bands. The refractive index of the first photonic structure is modulated, so that light supplied to the first photonic structure and initially in a first one of the photonic bands traveling along a forward direction in the at least first photonic structure is converted to light in a second one of the photonic bands, and light in the first photonic band traveling along a backward direction opposite to the forward direction in the at least first photonic structure is not converted and remains in the first photonic band. Light supplied to a first end of the first photonic structure and initially in the first photonic band traveling along a forward direction in the photonic structures will pass to a second end of the first photonic structure, and light supplied to the second end of the first photonic structure and traveling along a backward direction in the photonic structures will pass to an end of the second photonic structure. | 01-06-2011 |
| 20110001981 | FIBER BRAGG GRATING DEVICES UTILIZING SLOW LIGHT - In certain embodiments, an optical device and a method of use is provided. The optical device includes a fiber Bragg grating having a substantially periodic refractive index modulation along a length of the fiber Bragg grating. The fiber Bragg grating has a power transmission spectrum with a plurality of local transmission minima, wherein each pair of neighboring local transmission minima has a local transmission maximum therebetween. The local transmission maximum has a maximum power at a transmission peak wavelength. The optical device further includes a narrowband optical source in optical communication with a first optical path and a second optical path. The narrowband optical source is configured to generate light having a wavelength at or in the vicinity of a local transmission maximum or at or in the vicinity of a wavelength at which the power transmission spectrum has a maximum slope between a local transmission maximum and either one of two local transmission minima neighboring the local transmission maximum. | 01-06-2011 |
| 20100330110 | THERAPEUTIC AND DIAGNOSTIC USES OF ANTIBODY SPECIFICITY PROFILES - This invention provides a method for determining the antibody specificity profile in an individual. This specificity profile reveals the individual's immune response to multiple antigens and/or epitopes of autoantigens, allergens, graft antigens, etc. The antibody specificity profile is determined through the binding of patient samples comprising antibodies to the arrays. The array can comprises antigens and epitopes. The invention also provides the means and methods for determining antigen or epitope specificity profiles that can be used in the development of either generic and individualized diagnosis and treatment for immune related diseases, including autoimmune disease, allergy and graft rejection. | 12-30-2010 |
| 20100325185 | ALGORITHM FOR ADIABATIC PULSE DESIGN USING THE SHINNAR LE-ROUX TRANSFORM - A method for providing an adiabatic RF pulse that is an inversion or refocusing pulse for a RF pulse sequence is provided. A linear phase frequency profile (F | 12-23-2010 |
| 20100311917 | METHODS FOR MAKING MULTI-BRANCHED POLYMERS - A method for making a multi-branched polymer includes reacting a first polymeric unit with a functional cyclic compound to form a functional macroinitiator compound with a cyclic moiety. The functional macroinitiator compound is reacted with an amine functional compound to open the cyclic moiety and form a first functional group and a second functional group. To form the branched polymer, at least one of a second polymeric unit is propagated from the first functional group and a third polymeric unit is propagated from the second functional group. | 12-09-2010 |
| 20100304985 | METHODS AND COMPOSITIONS FOR DETERMINING WHETHER A SUBJECT CARRIES A DISEASE ASSOCIATED GENE MUTATION COMMON IN JEWISH POPULATIONS - Methods are provided for determining whether a subject carries a disease associated gene mutation common in Jewish populations. In practicing the subject methods, an array comprising a plurality of associated gene mutation probes is contacted with a nucleic acid sample from the subject, and the presence of any resultant surface bound target nucleic acids is detected to determine whether the subject carries an disease associated gene mutation common in Jewish populations. In addition, reagents and kits thereof that find use in practicing the subject methods are provided. | 12-02-2010 |
| 20100298431 | Method of improving cognitive functions in individuals with down syndrome and/or alzheimer's disease - A method of treating an individual having Down syndrome or Alzheimer's disease, which entails the step of administering an amount of one or more compounds to the individual which improve cognitive functioning in the individual by increasing hippocampal NE levels. | 11-25-2010 |
| 20100292803 | COMPOSITIONS AND METHODS FOR FORMING AND CLINICALLY UTILIZING ARTICULATING SPACING DEVICES - The present invention provides molds and methods for producing articulating spacers that are custom-fit to the bone and can be used in two-stage revision knee arthroplasty and other orthopaedic surgery. | 11-18-2010 |
| 20100291578 | Droplet-Based Pyrosequencing - The present invention relates to droplet-based pyrosequencing including a method of identifying a base at a target position in a sample nucleic acid. The method includes: (a) providing a droplet microactuator including a first droplet including a sample nucleic acid immobilized on a bead; and (b) on the droplet microactuator: (i) contacting the first droplet with one or more reagent droplets to yield a second droplet, wherein the one or more reagent droplets include reagents for extending a double stranded portion of the sample nucleic acid by incorporating a nucleotide at the target position; (ii) splitting the second droplet to yield a third droplet including the bead and a fourth droplet lacking the bead; and (iii) assaying the third droplet to determine whether the nucleotide was incorporated at the target position. | 11-18-2010 |
| 20100283538 | FREQUENCY OFFSET CARTESIAN FEEDBACK SYSTEM - An amplifier system providing improved Cartesian feedback is provided. A complex band pass error amplifier is provided. A quadrature up converter is connected to the complex band pass error amplifier so as to receive as input, output from the complex band pass error amplifier. An amplifier is connected to the quadrature up converter so as to receive as input, output from the quadrature up converter. A quadrature down converter is connected at or beyond the amplifier output so as to receive as input a signal proportional to that delivered by the amplifier as output to a load, wherein the complex band pass error amplifier is connected to the quadrature down converter so as to receive as a first input, output from the quadrature down converter and as a second input, a quadrature reference signal. | 11-11-2010 |
| 20100283463 | METHOD AND APPARATUS FOR FIELD MAP ESTIMATION - A method for estimating values of a field map to generate a magnetic resonance display image with species separation is provided. A set of MR images is acquired based on an applied magnetic resonance excitation. A set of feasible field map values for each pixel in a field map are determined from the set of MR images. Estimated values of the field map for each pixel are chosen from the set of feasible field map values using a combinatorial optimization algorithm that includes a smoothness constraint. The combinatorial optimization algorithm includes iteratively communicating, between neighboring pixels in the field map, sum-product belief messages that include likelihoods for feasible field map values. Field map values are fixed to most likely field map values if the pixel satisfies the smoothness constraint with its neighboring pixels. A magnetic resonance display image with species separation is generated using the estimated field map. | 11-11-2010 |
| 20100279302 | METHODS OF PREDICTING PAIRABILITY AND SECONDARY STRUCTURES OF RNA MOLECULES - Provided are methods of predicting a pairability of nucleotides of a plurality of RNA polynucleotides by (a) simultaneously determining a paired state or an unpaired state of nucleotides of the plurality of RNA polynucleotides; and (b) corresponding the paired state or the unpaired state of the nucleotides to a database of nucleic acid sequences, the database comprises nucleic acid sequences representing the plurality of RNA polynucleotides, thereby determining the pairability of nucleotides of the plurality of RNA polynucleotides. Also provided are methods of determining a secondary structure of a plurality of RNA molecules; methods of determining if a molecule is capable of modulating a secondary structure of at least one RNA polynucleotide of a plurality of RNA polynucleotides; and methods of screening for a marker associated with a pathology. | 11-04-2010 |
| 20100278400 | THREE-DIMENSIONAL SINGLE-MOLECULE FLUORESCENCE IMAGING BEYOND THE DIFFRACTION LIMIT USING A DOUBLE-HELIX POINT SPREAD FUNCTION - Embodiments of the present invention can resolve molecules beyond the optical diffraction limit in three dimensions. A double-helix point spread function can be used to in conjunction with a microscope to provide dual-lobed images of a molecule. Based on the rotation of the dual-lobed image, the axial position of the molecule can be estimated or determined. In some embodiments, the angular rotation of the dual-lobed imaged can be determined using a centroid fit calculation or by finding the midpoints of the centers of the two lobes. Regardless of the technique, the correspondence between the rotation and axial position can be utilized. A double-helix point spread function can also be used to determine the lateral positions of molecules and hence their three-dimensional location. | 11-04-2010 |
| 20100272729 | MAMMALIAN TUMOR SUSCEPTIBILITY GENE PRODUCTS AND THEIR USES - The present invention provides methods and compositions for regulating ubiquitination in a cell. In particular, the present invention provides purified polypeptides comprising an ubiquitination-regulating domain. The invention also provides methods of using such polypeptides for screening for agents, for producing antibodies, and for treatment of diseases, e.g., proliferative diseases, neurodegenerative diseases, autoimmune diseases, metabolic disease and developmental abnormalities. The invention further provides antibodies that bind an ubiquitination-regulating domain and agents and antibodies that regulate ubiquitination in cells, e.g., by modulating the interaction between a TSG101 protein and an MDM2 protein. | 10-28-2010 |
| 20100272728 | MAMMALIAN TUMOR SUSCEPTIBILITY GENE PRODUCTS AND THEIR USES - The present invention provides methods and compositions for regulating ubiquitination in a cell. In particular, the present invention provides purified polypeptides comprising an ubiquitination-regulating domain. The invention also provides methods of using such polypeptides for screening for agents, for producing antibodies, and for treatment of diseases, e.g., proliferative diseases, neurodegenerative diseases, autoimmune diseases, metabolic disease and developmental abnormalities. The invention further provides antibodies that bind an ubiquitination-regulating domain and agents and antibodies that regulate ubiquitination in cells, e.g., by modulating the interaction between a TSG101 protein and an MDM2 protein. | 10-28-2010 |
| 20100267826 | Treatment of ischemic episodes and cerebroprotection through Prostaglandin E2 (PGE2) EP2 and/or EP4 receptor agonists - The present invention provides compositions and methods for treating an ischemic episode using PGE | 10-21-2010 |
| 20100267134 | Isolation, characterization and differentiation of in vitro adult human germ line stem cells - A method of in vitro maturation of adult human germ line cells in an artificial biological environment, which entails:
| 10-21-2010 |
| 20100261619 | Charge Perturbation Detection System for DNA and Other Molecules - Methods and apparatus for direct detection of chemical reactions are provided. In a preferred embodiment, electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The target molecule is preferably DNA. The charge perturbation caused by the polymerase reaction can uniquely identify a DNA sequence. The polymerization process generates local perturbations of charge in the solution near the electrode surface and induces a charge in a polarazible gold electrode. This event is detected as a transient current by a voltage clamp amplifier. Detection of single nucleotides in a sequence can be determined by dispensing individual dNTPs to the electrode solution and detecting the charge perturbations. Alternatively, multiple bases can be determined at the same time using a mix of all dNTPs with subsequent analysis of the resulting signal. The initial enzyme attachment to the DNA molecule can be detected prior to polymerization, with electrode capacitance measurement using the same voltage-clamp amplifier. This technique and device may be adapted to other reaction determinations, such as enzymatic reactions, other electrode configurations, and other amplifying circuits. | 10-14-2010 |
| 20100255493 | Non-Invasive Fetal Genetic Screening by Digital Analysis - The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents. | 10-07-2010 |
| 20100255492 | Non-Invasive Fetal Genetic Screening by Digital Analysis - The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents. | 10-07-2010 |
| 20100248421 | Method of forming organic thin film and method of manufacturing semiconductor device using the same - Provided are a method of forming an organic semiconductor thin film and a method of manufacturing a semiconductor device using the. According to example embodiments, a method of forming an organic semiconductor thin film at least may include exposing a lower substrate coated with an organic semiconductor solution using a method of generating a shearing stress to the portion of the lower substrate coated with the organic semiconductor solution. A guide structure may be formed adjacent to the organic semiconductor solution. | 09-30-2010 |
| 20100234916 | System and method for ventricular pace timing based on isochrones - The present invention provides a system and method for displaying ventricular timing events and for determining optimal ventricular pace timing based on ventricular synchrony and loading conditions in order to improve the hemodynamic performance of patients. | 09-16-2010 |
| 20100224494 | Isotachophoretic Focusing of Nucleic Acids - A method and system are presented for fast and efficient isolation, purification and quantitation of nucleic acids from complex biological samples using isotachophoresis in microchannels. In an embodiment, a sieving medium may be used to enhance selectivity. In another embodiment, PCR-friendly chemistries are used to purify nucleic acids from complex biological samples and yield nucleic acids ready for further analysis including for PCR. In another embodiment, small RNAs from biological samples are extracted, isolated, preconcentrated and quantitated using on-chip ITP with a high efficiency sieving medium. The invention enables fast concentration and separation (takes 10s to 100s of seconds) of nucleic acids with high selectivity and using lower volumes of reagents (order of 10s of μL to focus less than 1 pg/μL of nucleic acid). | 09-09-2010 |
| 20100218286 | Modulated microwave microscopy and probes used therewith - A microwave microscope including a probe tip electrode vertically positionable over a sample and projecting downwardly from the end of a cantilever. A transmission line connecting the tip electrode to the electronic control system extends along the cantilever and is separated from a ground plane at the bottom of the cantilever by a dielectric layer. The probe tip may be vertically tapped near or at the sample surface at a low frequency and the microwave signal reflected from the tip/sample interaction is demodulated at the low frequency. Alternatively, a low-frequency electrical signal is also a non-linear electrical element associated with the probe tip to non-linearly interact with the applied microwave signal and the reflected non-linear microwave signal is detected at the low frequency. The non-linear element may be semiconductor junction formed near the apex of the probe tip or be an FET formed at the base of a semiconducting tip. | 08-26-2010 |
| 20100209950 | GRANULOCYTE-BASED METHODS FOR DETECTING AND MONITORING IMMUNE SYSTEM DISORDERS - Methods are provided for determining a subject's susceptibility to an allergic reaction upon exposure to an offending allergen. Methods are also provided for determining and monitoring a subject's responsiveness to ongoing allergy treatment | 08-19-2010 |
| 20100202584 | OPTIMAL WEIGHTS FOR MEASURING SPECTRAL X-RAY DATA - A method for determining a composition of an object using a spectral x-ray system is provided. X-ray photons of at least two different energies are transmitted through the object. The energy of each detected x-ray photon using a detector in the x-ray system is estimated. A first weighted sum of the number of detected photons of each energy is found using a first weighting function, wherein the first weighting function is dependent on the attenuation coefficient function of a first material. In another embodiment, the photons are binned into two energy bins wherein there is a gap between the energy bins. | 08-12-2010 |
| 20100198671 | RECYCLING REWARD SYSTEM AND METHOD THEREOF - Systems and methods are provided for incentivizing and rewarding consistent and repeated recycling of recyclable materials. | 08-05-2010 |
| 20100197613 | METHODS FOR INHIBITION OF NKT CELLS - Molecules that interact with the NKT cell antigen receptor and its counterpart antigen presenting molecule, but which inhibit the NKT cell immune function, are administered to a patient. Conditions of particular interest include the treatment of systemic lupus erythematosus (SLE), cancer, atherosclerosis, and allergic disease. In some embodiment of the invention, the inhibitory agent is an anergizing glycolipid, for example β-galactosylceramide. Pharmaceutical formulations of such glycolipids are provided, and find use in the treatment of diseases involving undesirable NKT cell activation. | 08-05-2010 |
| 20100195921 | Universal Lossy Compression Methods - The present invention provides methods for universal lossy compression that provide performance at or near the rate-distortion limit and that are based on universal, implementable lossy source coding algorithms. | 08-05-2010 |
| 20100179763 | DETECTION OF COUPLED RF CURRENT MRI BODIES - A method for detecting coupled RF current magnetic resonance (MR) objects in a body and determining MR risk is provided. The body is scanned with reverse circularly polarized RF. MR signals generated by coupling of the reverse circularly polarized RF with the RF current MR objects are detected. The detected MR signals are used to determine a risk value. | 07-15-2010 |
| 20100178292 | CRYPTIC GLYCAN MARKERS AND APPLICATIONS THEREOF - The present invention relates to a novel glycan marker of cancer and monoclonal antibodies against it. Furthermore, novel glycan markers and their use in the detection and monitoring of cancerous cells and cancer-associated or specific antibody signatures are described. | 07-15-2010 |
| 20100174206 | Method to discriminate arrhythmias in cardiac rhythm management devices - The present invention describes a covariance-based algorithm for the specific and sensitive discriminantion of heart rhythms in cardiac rhythm management devices. | 07-08-2010 |
| 20100167286 | Pluripotent cell lines and methods of use thereof - Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation of a gene of interest are provided. | 07-01-2010 |
| 20100161561 | METHOD AND SYSTEM FOR DATA ARCHIVING - Disclosed is a method and system for archiving data. A server computer (or any computing device) receives data transmitted over a network from a client computer, wherein at least some of the data was previously collected by a scientific instrument during an experiment. After receiving the data, the server computer updates (e.g., creates) an index for the received data, archives the received data, and automatically transmits a notification to the client computer that the received data has been archived. | 06-24-2010 |
| 20100161079 | Skin stretch tactile feedback device - The tactile feedback device of the preferred embodiments includes at least one skin contact pad; at least one actuator designed to move the at least one skin contact pad and attached to the at least one skin contact pad in a manner suitable to allow the actuator to move the at least one skin contact pad; a processor coupled to the actuator that executes a control logic and functions to control the movements of the at least one actuator; the control logic functions to determine the motions of the at least one actuator and is designed to move the at least one actuator in a manner that stretches the skin of the user. The tactile feedback device of the preferred embodiments has been designed to provide feedback to a user in a way that provides the user with information regarding a task that they are performing. The tactile feedback device of the preferred embodiments, however, may be used for any suitable purpose. | 06-24-2010 |
| 20100159678 | GERMANIUM SUBSTRATE-TYPE MATERIALS AND APPROACH THEREFOR - Germanium circuit-type structures are facilitated. In one example embodiment, a multi-step growth and anneal process is implemented to grow Germanium (Ge) containing material, such as heteroepitaxial-Germanium, on a substrate including Silicon (Si) or Silicon-containing material. In certain applications, defects are generally confined near a Silicon/Germanium interface, with defect threading to an upper surface of the Germanium containing material generally being inhibited. These approaches are applicable to a variety of devices including Germanium MOS capacitors, pMOSFETs and optoelectronic devices. | 06-24-2010 |
| 20100159135 | PROCESS FOR IN SITU GENERATION OF HYDROGEN SULFIDE OR HYDROGEN SELENIDE GAS USING A SOLID PRECURSOR - The present disclosure relates to novel methods and apparatuses for generating hydrogen sulfide or hydrogen selenide gas from decomposition of a solid precursor. In some embodiments, the generated gas is cooled so as to condense a by-product of the decomposition and thereby increasing the purity of the gas. In some embodiments, the generated hydrogen sulfide or hydrogen selenide gas is used to prepare metal sulfide or metal selenide films. | 06-24-2010 |
| 20100152502 | METHODS FOR SILVER-PROMOTED FLUORINATION OF ORGANIC MOLECULES - The methods of the disclosure may be used for the fluorination of organic compounds, and in particular aryl organic compounds other than just benzyl halogens. It is within the scope of the present disclosure, for organic compounds comprising an electrophilic carbon atom and a halogen leaving group to be fluorinated by the methods of the disclosure. One aspect of the disclosure provides methods of introducing a fluorine atom onto an electrophilic carbon atom, comprising mixing an insoluble basic silver salt, an organic molecule containing a leaving group, an aqueous solution of hydrofluoric acid, and a polar solvent:water composition; incubating said mixture at a temperature of about 20° C. to about 35° C., thereby obtaining a fluorinated organic product. | 06-17-2010 |
| 20100148075 | SYSTEM AND METHOD FOR USING MULTIPLE COLLIMATION DATA FOR TOMOGRAPHY - Methods and systems for producing an image. A measurement is obtained, and a projector function is generated using the obtained measurement. The generated projector function is modified based on an a priori image. An image is reconstructed using the modified projector function. | 06-17-2010 |
| 20100144754 | Methods and Compositions for Treating or Preventing Narcotic Withdrawal Symptoms - This invention provides methods and pharmaceutical compositions for preventing or treating physical dependence and/or withdrawal associated with narcotic use, in particular by modulating a 5-HT3 receptor. Using a computational genetic approach in mice, a gene conserved between mice and humans was identified as candidate as a modulator of physical dependence to morphine. Administration of compounds that modulate 5-HT3 receptors was found to control withdrawal from morphine in mice and humans. | 06-10-2010 |
| 20100142887 | METHOD OF FABRICATING AN OPTICAL SWITCH - Aa method fabricates an optical switch comprising a microsphere coated with silicon nanocrystals. The method includes providing a silica optical fiber. The method further includes melting at least a portion of the fiber to form at least one silica microsphere. The method further includes coating the microsphere with a silica layer. The method further includes precipitating silicon nanocrystals within the silica layer by annealing the microsphere. The method further includes passivating the nanocrystals by annealing the microsphere in a hydrogen-containing atmosphere. | 06-10-2010 |
| 20100138165 | Noninvasive Diagnosis of Fetal Aneuploidy by Sequencing - Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated. By counting the number of sequence tags mapped to a predefined window in each chromosome, the over- or under-representation of any chromosome in maternal plasma DNA contributed by an aneuploid fetus can be detected. This method does not require the differentiation of fetal versus maternal DNA. The median count of autosomal values is used as a normalization constant to account for differences in total number of sequence tags is used for comparison between samples and between chromosomes. | 06-03-2010 |
| 20100133182 | MICROSPHERIC TIO2 PHOTOCATALYST - The present invention refers to titanium oxide microspheres having photocatalytic properties which can, for example, be used in a method for cleaning wastewater which uses a submerged membrane reactor. | 06-03-2010 |
| 20100124752 | Non-Invasive Fetal Genetic Screening by Digital Analysis - The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents. | 05-20-2010 |
| 20100124751 | Non-Invasive Fetal Genetic Screening by Digital Analysis - The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents. | 05-20-2010 |
| 20100124310 | DATA NORMALIZATION IN INVERSE GEOMETRY COMPUTED TOMOGRAPHY SYSTEM - A method for imaging an object in a computed tomography (CT) system with a plurality of sources comprising a first source and a second source, wherein the plurality of sources together with a detector array are mounted on a rotatable gantry, and wherein an intensity of the second source has unknown fluctuations is provided. Projection data is collected using the first source in a first gantry position. Projection data is collected using the second source in a second gantry position, wherein projection data from the first source in the first gantry position substantially overlaps projection data from the second source in the second gantry position. Data from the first source at the first gantry position is used to correct for source fluctuations of the second source at the second gantry position. | 05-20-2010 |
| 20100120631 | Methods for detecting hepatocellular carcinoma - A method for evaluating hepatocellular carcinoma in a subject is provided. In certain embodiments, the method comprises: a) obtaining a hepatocellular carcinoma protein marker profile for a sample obtained from the subject; and b) comparing the protein marker profile to a control profile. | 05-13-2010 |
| 20100112575 | Noninvasive Diagnosis of Fetal Aneuploidy by Sequencing - Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated. By counting the number of sequence tags mapped to a predefined window in each chromosome, the over- or under-representation of any chromosome in maternal plasma DNA contributed by an aneuploid fetus can be detected. This method does not require the differentiation of fetal versus maternal DNA. The median count of autosomal values is used as a normalization constant to account for differences in total number of sequence tags is used for comparison between samples and between chromosomes. | 05-06-2010 |
| 20100112214 | Synthesis of Higher Diamondoids - In some embodiments, the present invention is directed to methods for synthesizing higher diamondoids, wherein said methods involve augmenting existing diamondoid molecules through the bonding of carbon atoms to such existing diamondoid species with intramolecular cross-linking so as to form larger diamondoids containing face-fused diamond-crystal (adamantane) cages with carbon frameworks superimposable on the cubic-diamond crystal lattice. | 05-06-2010 |
| 20100102812 | OPTIMIZED SPECTRAL-SPATIAL PULSE - A computer implemented method for designing a spectral-spatial pulse for exciting at least one passband and minimally exciting at least one stopband is provided. A uniform shaped spectral envelope is generated. For a plurality of k | 04-29-2010 |
| 20100098904 | Single-walled carbon nanotubes and methods of preparation thereof - The present invention provides single-walled carbon nanotubes and systems and methods for their preparation. | 04-22-2010 |
| 20100092125 | Optical structure on an optical fiber and method of fabrication - An optical structure on an optical fiber and a method of fabrication is provided. The optical structure includes an end of an optical fiber and a layer formed on the end of the optical fiber. The layer comprises one or more first portions having a first optical pathlength in a direction perpendicular to the layer and one or more second portions having a second optical pathlength in the direction perpendicular to the layer, the second optical pathlength different from the first optical pathlength. | 04-15-2010 |
| 20100085046 | HYPERPOLARIZED DYNAMIC CHEMICAL SHIFT IMAGING WITH TAILORED MULTIBAND EXCITATION PULSES - A method for performing magnetic resonance spectroscopy is described. The method generally includes applying a tailored multiband spectral-spatial radio frequency excitation pulse to a sample including a first species and at least a second species having a different resonant frequency than the first species. The multiband excitation pulse excites the first species according to a first amplitude and excites the second species according to a second amplitude that is substantially greater than the first amplitude. Data is acquired from the sample. The acquired data is then utilized to generate a spectroscopic output. By way of example, the spectroscopic output is a spectroscopic image. In particular embodiments, the data for the first and second species is acquired dynamically over an observation window of time. | 04-08-2010 |
| 20100080855 | HEDGEHOG SIGNALING AND CANCER STEM CELLS IN HEMATOPOIETIC CELL MALIGNANCIES - The present disclosure relates generally to methods of treating hematopoietic cell malignancy in a subject by administering to the subject a Hedgehog (Hh) pathway antagonist, such as a Smoothen (Smo) antagonist alone or in combination with an ABL-kinase antagonist. Specifically, the disclosure relates to a method of treating hematopoietic cell malignancy in a subject by administering the Hh pathway antagonist, such as the Smo antagonist cyclopamine, in combination with the ABL-kinase antagonist imatinib. | 04-01-2010 |
| 20100077847 | TIRE STATE ESTIMATOR AND TIRE STATE ESTIMATION METHOD - A tire state estimator includes a lateral force upper limit estimating section, a lateral force estimating section, and a tire slip angle estimating section. The lateral force upper limit estimating section calculates an estimated tire lateral force upper limit, on a basis of an estimated tire slip angle and a measured tire self aligning torque. The lateral force estimating section calculates an estimated tire lateral force, on a basis of the estimated tire lateral force upper limit calculated by the lateral force upper limit estimating section and the estimated tire slip angle. The tire slip angle estimating section calculates the estimated tire slip angle, on a basis of the estimated tire lateral force calculated by the lateral force estimating section and a measured vehicle state. | 04-01-2010 |
| 20100069250 | Digital PCR Calibration for High Throughput Sequencing - Disclosed is a method for accurately determining the number of template molecules in a library of nucleic acids (e.g., DNA) to be sequenced. The method does not require large amounts of the DNA sample, nor does it require the preparation of a standard curve. The method is especially applicable to methodologies for “sequencing by synthesis,” where quantitation of the starting library is important. The method uses quantitative real time PCR, especially digital PCR, which measures the number of individual molecules in a sample. The present method particularly may use a microfluidic device for running large numbers of PCR reactions. Each PCR reaction is monitored in real time by a primer/probe combination. The forward primer is adapted to contain a sequence not on the adapter but which corresponds to a probe sequence. A short probe which generates fluorescence during the PCR process is used. | 03-18-2010 |
| 20100068150 | Selective Caspase Inhibitors - Described here are novel, highly selective inhibitors and activity based probes (ABPs) for caspases 3, 7, 8, and 9 and legumain. The compounds selectively inhibit only certain caspases. A positional scanning combinatorial library (PSCL) approach was used to screen pools of peptide acyloxymethyl ketones (AOMKs) containing both natural and non-natural amino acids for activity against a number of purified recombinant caspases. These screens were used to identify structural elements at multiple positions on the peptide scaffold that could be modulated to control inhibitor specificity towards target caspases. Further disclosed are individual optimized covalent inhibitors that could also be equipped with various tags for use as activity based probes, as well as labeled substrates. | 03-18-2010 |
| 20100067827 | OPTICAL IMAGE PROCESSING USING MINIMUM PHASE FUNCTIONS - A method utilizes an optical image processing system. The method includes providing a measured magnitude of the Fourier transform of a complex transmission function of an object or optical image. The method further includes providing an estimated phase term of the Fourier transform of the complex transmission function. The method further includes multiplying the measured magnitude and the estimated phase term to generate an estimated Fourier transform of the complex transmission function. The method further includes calculating an inverse Fourier transform of the estimated Fourier transform, wherein the inverse Fourier transform is a spatial function. The method further includes calculating an estimated complex transmission function by applying at least one constraint to the inverse Fourier transform. | 03-18-2010 |
| 20100063258 | FUSION PROTEIN CONSTRUCTS - Polypeptide linkers with defined tertiary structures, usually of defined alpha helical structure, are used to join two domains in a fusion protein. In one embodiment of the invention, a method is provided for the cell-free synthesis of the fusion protein. | 03-11-2010 |
| 20100039649 | OPTICAL SENSOR UTILIZING HOLLOW-CORE PHOTONIC BANDGAP FIBER WITH LOW PHASE THERMAL CONSTANT - An optical sensor includes an optical coupler. The optical sensor further includes a photonic bandgap fiber having a hollow core and an inner cladding generally surrounding the core. The photonic bandgap fiber is in optical communication with the optical coupler. Light signals counterpropagate through the photonic bandgap fiber and return to the optical coupler. The photonic bandgap fiber has a phase thermal constant S less than 8 parts-per-million per degree Celsius. | 02-18-2010 |
| 20100033179 | DISTORTION-FREE MAGNETIC RESONANCE IMAGING NEAR METALLIC IMPLANTS - A method for 3D magnetic resonance imaging (MRI) with slice-direction distortion correction is provided. One or more selective cross-sections with a thickness along a first axis is excited using a RF pulse with a bandwidth, wherein a selective cross-section is either a selective slice or selective slab. A refocusing pulse is applied to form a spin echo. One or more 2D encoded image signals are acquired with readout along a second axis and phase encoding along a third axis. Slice-direction distortion is corrected by resolving the position by resolving the frequency offset. | 02-11-2010 |
| 20100028681 | Pristine and Functionalized Graphene Materials - Disclosed are dispersed graphene sheets, ribbons, graphene molecules and the like which are pristine in the plane, i.e., free of significant defects and chemical modifications such as oxidation. The materials could be functionalized at the edges. These materials are dispersed in solutions rather than in aggregated or insoluble forms as their parent starting materials. Also disclosed is a method comprising the steps of intercalating an insoluble graphitic material. The method may comprise exfoliating graphite and re-intercalating the resultant material with an acid composition, such as oleum, and a strong organic base such as tetrabutylammonium hydroxide in a solvent solution to form a homogenous suspension, which is then agitated to form dispersed graphene materials. The materials may be solubilized with a hydrophilic polymer and can be further manipulated by transfer into different solvents, formation of films, application to optical and electronic devices, and other applications. The materials are solubilized by functional groups mostly at the edges. | 02-04-2010 |
| 20100026294 | BLIP DESIGN FOR RANDOM SAMPLING COMPRESSED SENSING OF FLYBACK 3D-MRSI - A method of providing a magnetic resonance spectral image (MRSI) is provided. A magnetic resonance imaging excitation is applied. Data is acquired, comprising applying an oscillating gradient in a first dimension and applying blips in at least a second dimension in a pseudo-random order to acquire pseudo-random temporally undersampled spectral data in at least two planes. The pseudo-random order is used to reconstruct a magnetic resonance spectral image in at least two dimensions. | 02-04-2010 |
| 20100021115 | OPTICAL DEVICE USING A HOLLOW-CORE PHOTONIC-BANDGAP FIBER - An optical device includes a hollow-core photonic-bandgap fiber, wherein at least a portion of the hollow-core photonic-bandgap fiber is adjustably axially twisted. | 01-28-2010 |
| 20100003735 | Mild Chemically Cleavable Linker System - A linker system is provided where a small molecule reactive group, e.g., an activity based probe which binds to certain enzymes at the active site, is linked through an aryl diazo linker to an affinity molecule such as biotin. The reactive group may comprise a number of functionalities known to react with a specific target to be studied. This enables the probe to be exposed to analytes, such as proteins and bind specifically to them to form a complex having an affinity molecule allowing immobilization of the bound analyte on an affinity column or other support, e.g. with streptavidin. Then, the linker is cleaved without causing removal of the affinity group or dissociation of the probe from the analyte. The linker is cleaved under mild reducing conditions, e.g., dithionite. The probe is synthesized along with the linker on a solid support. | 01-07-2010 |
| 20090315558 | SELF-REFOCUSED SPATIAL-SPECTRAL PULSE - A method for frequency selective and slice selective magnetic resonance imaging (MRI) is provided. A B | 12-24-2009 |
| 20090312362 | INHIBITORS OF THE UNFOLDED PROTEIN RESPONSE AND METHODS FOR THEIR USE - Compounds that are inhibitors of the unfolded protein response and endonuclease IRE1 are provided, together with compositions comprising such compounds, and methods for their use in the treatment of various disorders, such as cancer, autoimmune disorders, and diabetes. Also provided are packaged pharmaceuticals comprising these compositions. The compositions may be administered in combination with another therapeutic agent. | 12-17-2009 |
| 20090309484 | DIRECT BAND-GAP NANODIAMOND CRYSTALS AND ULTRAVIOLET OPTICAL DEVICES USING THE SAME - Novel direct band gap crystalline nanodiamonds and light emitting devices utilizing the direct band gap crystalline nanodiamonds are disclosed. With providing the detailed information on the electronic states and the electron band structure of several crystalline nanodiamonds, preferred device structures including an electroluminescence-based solid-state light source and a cathode-luminescence-based micro light source are shown. These devices emit light in the region of ultraviolet wavelength, which can be designed from 180 nm to 230 nm by a choice of nanodiamonds, with referring to the information provided in the present invention. The related applications of these UV light emitting devices include a light source for sterilization, a light source for decomposing harmful substances, a light source for spectroscopy, a light source for exciting a phosphor to emit a white light, a micro light source for micro optoelectronic devices, and a light source for writing a super high density recording media. | 12-17-2009 |
| 20090306496 | AUTOMATIC SEGMENTATION OF ARTICULAR CARTILAGE FROM MRI - A method for musculoskeletal tissue segmentation used in magnetic resonance imaging (MRI) is provided. MRI image data is collected using at least two different contrast mechanisms. Voxel values from data from each contrast mechanism are used as elements of a feature vector. The feature vector is compared with classification boundaries to classify musculoskeletal tissue type of the voxel. The previous two steps are repeated for a plurality of voxels. An image is generated from the classified musculoskeletal tissue types for the plurality of voxels to provide a musculoskeletal segmentation image. | 12-10-2009 |
| 20090297868 | Method for Forming Self-Assembled Monolayer Film, and Structural Body and Field-Effect Transistor Having Same - A method for forming a self-organized monomolecular film, including at least: dissolving an alkylsilane compound having at least an alkoxysilane group or a chlorosilane group at one end of a molecule in an organic solvent having a dielectric constant of 3.0 or more to 6.0 or less to obtain a solution; subsequently coating the solution on a base material or immersing the base material into the solution; and subsequently drying the solution located on the base material. | 12-03-2009 |
| 20090291857 | METHODS TO IDENTIFY INHIBITORS OF THE UNFOLDED PROTEIN RESPONSE - Methods for identifying compounds that are inhibitors of the unfolded protein response are provided. In particular, the methods identify compounds that inhibit the activity of IRE1. | 11-26-2009 |
| 20090285581 | Passive Optical Network Comprising an Optical Burst Mode Receiver - A passive optical network is disclosed that enables burst mode operation without some of the disadvantages for doing so in the prior art. An embodiment of the present invention comprises a receiver that receives optical signals from transmitters of a plurality of optical network units. For each transmission from an optical network unit, the receiver provides an output signal based on a comparison of the optical signal and a reference voltage that is specific to that optical network unit. A digital-to-analog converter generates the reference voltage in a data rate-independent manner based on information provided to it from the control plane. | 11-19-2009 |
| 20090281170 | POLYNUCLEOTIDE THERAPY - This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal. | 11-12-2009 |
| 20090268804 | Delayed decision feedback sequence estimator - Disclosed is a delayed decision feedback sequence estimator comprising a delayed decision feedback sequence estimator main unit including DDFSE computing unit group including (L+M) DDFSE computing units, equal in number to a length of each of plurality of blocks into which a received data symbol sequence is divided; wherein (L+M) DDFSE computing units are connected in a pipeline configuration to execute delayed decision feedback sequence estimation of the blocks in parallel; and an edge effect detection and correction circuit that detects an edge effect due to processing the delayed decision feedback sequence estimation of the separated block and corrects a relevant bit error. | 10-29-2009 |
| 20090264515 | POLYNUCLEOTIDE THERAPY - This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal. | 10-22-2009 |
| 20090258792 | Prostate Cancer Glycan Markers and Autoantibody Signatures - Disclosed are methods for probing the immunogenic sugar moieties of prostate cancer cells. The methods detect a number of glyco-epitopes that are highly and differentially expressed among prostate cancers of various Gleason grades. The glyco-epitopes exist on the surfaces of prostate cells. The methods also comprise the detection of autoantibodies in prostate cancer subjects. The antibodies bound to a glyco-motif of N-glycans that is normally “cryptic.” This target is highly expressed in prostate cancers. Lectins and antibodies that detect these glyco-epitopes that expressed in prostate cancer tissues include | 10-15-2009 |
| 20090257952 | Engineered Integrin Binding Peptides - Engineered peptides that bind with high affinity (low equilibrium dissociation constant (Kd)) to the cell surface receptors of fibronectin (α | 10-15-2009 |
| 20090252677 | Probes for In Vivo Targeting of Active Cysteine Proteases - Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) “warhead” that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such as | 10-08-2009 |
| 20090244544 | UNIDIRECTIONAL CROW GYROSCOPE - An optical waveguide gyroscope includes at least one optical coupler configured to receive a first optical signal at a first port, to transmit a second optical signal to a second port, and to transmit a third optical signal to a third port. The optical waveguide gyroscope further includes a plurality of resonant waveguides optically coupled to the second port and the third port. The resonant waveguides are generally adjacent to one another and optically coupled to one another. At least a portion of the second optical signal propagates from the second port to the third port by propagating through the plurality of resonant waveguides, and at least a portion of the third optical signal propagates from the third port to the second port by propagating through the plurality of resonant waveguides. The at least a portion of the second optical signal propagates through each resonant waveguide of the plurality of resonant waveguides in a clockwise direction and the at least a portion of the third optical signal propagates through each resonant waveguide of the plurality of resonant waveguides in a counterclockwise direction. | 10-01-2009 |
| 20090230958 | SLICE-SELECTIVE TUNABLE-FLIP ADIABATIC LOW PEAK POWER EXCITATION - A manifestation of the invention provides a method for slice selective excitation for magnetic resonance imaging (MRI). A B | 09-17-2009 |
| 20090220979 | Methods and Apparatus for Magnetic Separation of Cells - Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput. | 09-03-2009 |
| 20090212775 | MR COMPATIBLE ROTATING ANODE X-RAY TUBE - An apparatus for use in a magnetic resonance (MR) system, which generates an external MR magnetic field, is provided. A rotor comprises a rotor shaft with an axis along a length of the rotor shaft and a plurality of coils on the rotor shaft. A housing supports and surrounds the rotor, where a part of the housing surrounds sides of the rotor and where the part of the housing surrounding sides of the rotor is magnet free. A mount allows for the mounting of the housing to the MR system in a location where the MR system provides a magnetic field, wherein a component of the MR magnetic field that is perpendicular to the axis of the rotor shaft is at least 100 Gauss. An active timer applies a voltage to the plurality of coils with alternating polarity. Contacts provide an electrical connection between the active timer and the plurality of coils. | 08-27-2009 |
| 20090208163 | HIGH-SENSITIVITY FIBER-COMPATIBLE OPTICAL ACOUSTIC SENSOR - An acoustic sensor includes at least one photonic crystal structure having at least one optical resonance with a resonance frequency and a resonance lineshape. The acoustic sensor further includes a housing mechanically coupled to the at least one photonic crystal structure. At least one of the resonance frequency and the resonance lineshape is responsive to acoustic waves incident upon the housing. | 08-20-2009 |
| 20090207414 | APPARATUS AND METHOD FOR OPTICAL COHERENCE TOMOGRAPHY - An apparatus is provided for measuring a frequency-domain optical coherence tomography power spectrum from a sample. The apparatus includes a broadband light source, an optical spectrum analyzer, and a partially reflective element optically coupled to the light source, to the optical spectrum analyzer, and to the sample. A first portion of light from the light source is reflected by the partially reflective element and propagates to the optical spectrum analyzer. A second portion of light from the light source propagating through the partially reflective element, impinging the sample, reflecting from the sample, and propagating to the optical spectrum analyzer. | 08-20-2009 |
| 20090207401 | APPARATUS FOR CHARACTERIZING FIBER BRAGG GRATINGS - An apparatus characterizes at least one fiber Bragg grating. The apparatus includes a laser pulse source, an optical spectrum analyzer, and multiple optical paths. A first optical path includes a pulse stretcher and an attenuator. A second optical path optically coupled to the first optical path includes a mirror. A third optical path optically coupled to the first optical path includes a first fiber Bragg grating. A fourth optical path is optically coupled to the second optical path, the third optical path, and the optical spectrum analyzer. A fifth optical path optically coupled to the laser pulse source and the optical spectrum analyzer includes a delay line. | 08-20-2009 |
| 20090196478 | AUTO CALIBRATION PARALLEL IMAGING RECONSTRUCTION METHOD FROM ARBITRARY K-SPACE SAMPLING - A method for obtaining an image by parallel acquisition magnetic resonance imaging (MRI) is provided. Precessing nuclear spins are excited in a region of a subject. A plurality of response signals, representing magnetic resonance signals arising from the precessing nuclear spins, are simultaneously obtained from the region respectively with a plurality of RF reception coils, with each response signal representing a reduced data set of a totality of all of said response signals. Calibration data points are additionally obtained for each data set. A filter is synthesized using the calibration data points. The synthesizing filter is applied to the reduced data set to obtain a plurality of coupled simultaneous linear equations with a plurality of unknowns. The plurality of coupled simultaneously linear equations with the plurality of unknowns is solved to obtain a complete data set. | 08-06-2009 |
| 20090195879 | DETERMINISTIC APERIODIC PATTERNED DIELECTRIC AND PLASMONIC MATERIALS FOR LOCALIZED ELECTROMAGNETIC FIELD ENHANCEMENT - A method is shown for the extension in higher spatial dimensions of deterministic, aperiodic structures which exhibit strong aperiodic effects and have overall compatibility with the planar technology of integrated optical circuits. Disclosed devices are operative in response to incident electromagnetic energy to create a distribution of electromagnetic energy having localized electromagnetic field enhancement, wherein the device includes a dielectric or plasmonic material having a region of interaction with the incident electromagnetic energy. The region of interaction has a deterministic, aperiodic patterning with an array of individual patterning elements of distinct refractive indices such that a variation of refractive index of the device occurs over distances comparable with a wavelength of the incident electromagnetic energy, the array being a multi-dimensional extension of a corresponding one-dimensional sequence such that a spectral response of the array is a multi-dimensional equivalent of a spectral response of the one-dimensional sequence. Specific examples employing so-called Rudin-Shapiro, Thue-Morse and Fibonacci sequences are shown. | 08-06-2009 |
| 20090195785 | LOW-NOISE FIBER OPTIC SENSOR UTILIZING A LASER SOURCE - A fiber-optic sensor includes an optical fiber coil and a laser source optically coupled to the coil. Light from the source is transmitted to the coil as a first signal propagating along the coil in a first direction and a second signal propagating along the coil in a second direction opposite to the first direction. The optical paths of the first signal and the second signal are substantially reciprocal with one another and the first signal and the second signal are combined together after propagating through the coil to generate a third signal. The laser source is frequency-modulated or can have a coherence length longer than a length of the coil. | 08-06-2009 |
| 20090192769 | METHOD AND APPARATUS FOR MODELING THE MODAL PROPERTIES OF OPTICAL WAVEGUIDES - A method and apparatus models one or more electromagnetic field modes of a waveguide. The method includes calculating a first matrix having a plurality of elements and having a first bandwidth using a refractive index profile of the waveguide. The plurality of elements of the first matrix represents an action of Maxwell's equations on a transverse magnetic field within the waveguide. The method further includes rearranging the plurality of elements of the first matrix to form a second matrix having a second bandwidth smaller than the first bandwidth. The method further includes shifting the second matrix and inverting the shifted second matrix to form a third matrix. The method further includes calculating one or more eigenvalues or eigenvectors of the third matrix corresponding to one or more modes of the waveguide. | 07-30-2009 |
| 20090187046 | Process to Produce Prostratin and Structural or Functional Analogs Thereof - This invention concerns a process to convert a hydroxyl group (bold in R | 07-23-2009 |
| 20090182278 | EXPANDABLE GUIDE SHEATH AND APPARATUS AND METHODS FOR USING SUCH SHEATHS - Apparatus and methods are provided for accessing body lumens and/or for delivering instruments into body lumens, e.g., vessels within a patient's vasculature. A flexible sheath is provided that is expandable from a contracted condition to an enlarged condition wherein the sheath at least partially defines a lumen therein. The sheath is lubricious and has a relatively thin wall, thereby providing a collapsible/expandable guide for delivering fluids and/or instruments through tortuous anatomy and/or into relatively narrow passages. The sheath is advanced from an entry site to a body lumen in the contracted condition. Once the sheath reaches a target body lumen, the sheath is expanded to the enlarged condition, thereby defining a lumen within the sheath, and fluids and/or instruments are introduced into the body lumen via the sheath lumen. Upon completing the procedure, the sheath is removed from the body lumen. | 07-16-2009 |
| 20090175584 | OPTICAL FIBER WITH A CORE RING - An optical fiber includes a cladding with a material having a first refractive index and a pattern of regions formed therein. Each of the regions has a second refractive index lower than the first refractive index. The optical fiber further includes a core region and a core ring having an inner perimeter, an outer perimeter, and a thickness between the inner perimeter and the outer perimeter. The thickness is sized to reduce the number of ring surface modes supported by the core ring. | 07-09-2009 |
| 20090174403 | FIELD MAP ESTIMATION FOR SPECIES SEPARATION - A method for mapping field inhomogeneity for forming a magnetic resonance image is provided. A magnetic resonance excitation is applied. A plurality of k-space echoes signals is acquired. A periodic cost function is calculated from the acquired plurality of k-space echo signals. A period of the calculated periodic cost function is divided into multiple regions. A search algorithm is used to locate a local minimum in each region. Located local minimums are chosen to provide global smoothness. | 07-09-2009 |
| 20090170114 | Non-Invasive Fetal Genetic Screening by Digital Analysis - The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents. | 07-02-2009 |
| 20090170113 | Non-Invasive Fetal Genetic Screening by Digital Analysis - The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents. | 07-02-2009 |
| 20090143394 | COMPOUNDS FOR ACTIVATING TGF-BETA SIGNALING - Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-β signaling are described. | 06-04-2009 |
| 20090137897 | METHOD FOR MAGNETIC RESONANCE SPECTROSCOPIC IMAGING - A method for performing spectroscopy using an interleaved readout for at least two species. A B | 05-28-2009 |
| 20090130091 | COMPOUNDS FOR HEDGEHOG PATHWAY BLOCKADE IN PROLIFERATIVE DISORDERS, INCLUDING HEMATOPOIETIC MALIGNANCIES - Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in hematopoietic malignancy cells, and determined to be associated with growth and proliferation of the malignancy cells. Accordingly, methods are provided for treating a hematopoietic cell malignancy associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of determining the responsiveness of a hematopoietic cell malignancy to treatment with an Hh pathway antagonist. | 05-21-2009 |
