The Board of Trustees of the Leland Stanford Junior University Patent applications |
Patent application number | Title | Published |
20160138105 | SYSTEM AND METHODS FOR DETERMINING A WOMAN'S RISK OF ANEUPLOID CONCEPTION - The present invention provides methods and systems for determining a woman's risk of carrying an aneuploid embryo based on the maternal genotype, maternal age and optionally paternal age. | 05-19-2016 |
20160135702 | Techniques for Predicting Cardiac Arrhythmias Based on Signals from Leads of Electrocardiography - Techniques for predicting cardiac arrhythmia includes obtaining first data that indicates an electrocardiography recording from a patient; and, automatically deriving, on a processor, P-wave characteristics on a plurality of leads of the electrocardiography recording. A value for a first parameter, Pindex3, is determined based on a standard deviation of P-wave duraations automatically derived from only three leads of the plurality of leads. A risk of incidence of cardiac arrhythmia for the patient is determined based, at least in part, on the first parameter, Pindex3. | 05-19-2016 |
20160115558 | CONTROL OF METABOLIC FLUX IN CELL-FREE BIOSYNTHETIC SYSTEMS - Methods are provided for controlling metabolic flux rate in a cell-free system comprising a complex set of enzymes, to produce a desired product of a pathway of interest. In the methods of the invention, measurements of metabolic performance parameters are taken by continuous monitoring or intermittent monitoring. Based on the metabolic performance parameters, the system is modified by one or more steps comprising: (i) altering enzyme levels in the cell-free system; (ii) altering feed rate of a substrate that controls redox flux or carbon flux to the cell-free system; (iii) altering O | 04-28-2016 |
20160109428 | MECHANICAL BIOMARKERS FOR OOCYTE AND EMBRYO VIABILITY - Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo or oocyte, detecting a temporal response of the embryo or oocyte to the mechanical stimulus, and deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability. Also provided are methods for selecting an embryo for transfer and methods for enhancing the viability of an embryo or oocyte. | 04-21-2016 |
20160060655 | COMPOSITIONS AND METHODS TO TREAT LATENT VIRAL INFECTIONS - Viral infection is a persistent cause of human disease. Guided nuclease systems target the genomes of viral infections, rendering the viruses incapacitated. | 03-03-2016 |
20160058377 | Methods of Testing for Allergen Sensitivity - A method of testing for specificity and strength of an allergic reaction is performed by penetrating the skin of an individual with the microneedle array comprising a plurality of epitopes and determining the response of the skin to the allergens. The response can be measured with a thermal imaging device. Analysis, and optionally treatment, can be provided to the individual. | 03-03-2016 |
20160049291 | METHOD OF FORMING THIN FILM OF SEMICONDUCTOR DEVICE - Provided is a method of forming a thin film of a semiconductor device. The method includes forming a precursor layer on a surface of a substrate by supplying a precursor gas into a chamber, discharging the precursor gas remaining in the chamber to an outside of the chamber by supplying a purge gas into the chamber, supplying a reactant gas into the chamber, generating plasma based on the reactant gas, forming a thin film by a chemical reaction between plasma and the precursor layer and radiating extreme ultraviolet (EUV) light into the chamber, and discharging the reactant gas and the plasma remaining in the chamber by supplying a purge gas into the chamber. | 02-18-2016 |
20160033415 | DEVICE AND METHODS OF DETECTION OF AIRBORNE AGENTS - Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity. | 02-04-2016 |
20160024579 | NON-INVASIVE DETERMINATION OF FETAL INHERITANCE OF PARENTAL HAPLOTYPES AT THE GENOME-WIDE SCALE - The present invention provides a method, device and a computer program for haplotyping single cells, such that a sample taken from a pregnant female, without directly sampling the fetus, provides the ability to non-invasively determine the fetal genome. The method can be performed by determining the parental and inherited haplotypes, or can be performed merely on the basis of the mother's genetic information, obtained preferably in a blood or serum sample. The novel device allows for sequence analysis of single chromosomes from a single cell, preferably by partitioning single chromosomes from a metaphase cell into long, thin channels where a sequence analysis can be performed. | 01-28-2016 |
20160022654 | Methods of Improving Microvascular Integrity - The disclosure relates to methods of preserving or improving microvascular integrity in a patient in need thereof comprising administering pirfenidone therapy to the patient. | 01-28-2016 |
20160015265 | Implantable Micro-Fluidic Device for Monitoring of Intra-Ocular Pressure - Glaucoma is the second most common cause of blindness in the global world. It is a multifactorial disease with several risk factors, of which intraocular pressure (IOP) is the most important. IOP measurements are used for glaucoma diagnosis and patient monitoring. IOP has wide diurnal fluctuation, and is dependent on body posture, so the occasional measurements done by the eye care expert in clinic can be misleading. We provide an implantable sensor, based on microfluidic principles, which in one example has 1 mmHg limit of detection, high sensitivity and excellent reproducibility. This sensor has an optical interface, which enables IOP to be read with, for example, a cell phone camera. The design, fabrication, along with the option of self-monitoring are promising steps toward better patient care and treatment for this devastating disease. | 01-21-2016 |
20160000991 | DEVICE AND METHOD FOR RAPID ASPIRATION AND COLLECTION OF BODY TISSUE FROM WITHIN AN ENCLOSED BODY SPACE - Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through cannula into body tissue and is manipulated to advance directionally through body cavity. Optional stylet within aspiration cannula aids in advancing aspiration cannula through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula. Inlet openings near distal tip of aspiration cannula allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula providing controlled negative pressure. Aspiration cannula may be withdrawn and its path adjusted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue. | 01-07-2016 |
20150376583 | COMPOSITIONS AND METHODS TO TREAT LATENT VIRAL INFECTIONS - Viral infection is a persistent cause of human disease. Guided nuclease systems target the genomes of viral infections, rendering the viruses incapacitated. | 12-31-2015 |
20150370963 | Phased Whole Genome Genetic Risk In A Family Quartet - In an embodiment of the present invention, three novel human reference genome sequences were developed based on the most common population-specific DNA sequence (“major allele”). Methods were developed for their integration into interpretation pipelines for highthroughput whole genome sequencing. | 12-24-2015 |
20150370959 | Phased Whole Genome Genetic Risk In A Family Quartet - An embodiment of the present invention is a methodology for prioritizing variants relevant to inherited Mendelian (“single gene”) disease syndromes according to disease phenotype, gene, and variant level information. | 12-24-2015 |
20150368670 | COMPOSITIONS AND METHODS OF DELIVERING TREATMENTS FOR LATENT VIRAL INFECTIONS - The invention provides delivery methods and compositions for antiviral therapeutics. Methods and compositions are provided for targeted delivery of antiviral therapeutics into cells of interest using, for example, viral vectors such as adenovirus, AAV, and replication incompetent HSV. These and other delivery systems can be used as vehicles to deliver DNA vectors encoding a nuclease or a cell-killing gene. These delivery methods can also be used to deliver naked DNA or RNA, protein products, plasmids containing a promoter that is active only in a latent viral state which drives a cell-killing gene, or other therapeutic agents. | 12-24-2015 |
20150368326 | MODULATION OF SYNAPTIC MAINTENANCE - C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease. | 12-24-2015 |
20150368325 | MODULATION OF SYNAPTIC MAINTENANCE - C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease. | 12-24-2015 |
20150368324 | MODULATION OF SYNAPTIC MAINTENANCE - C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease. | 12-24-2015 |
20150366551 | PATIENT-SUPPORTED OPHTHALMIC PLATFORMS - Patient-supported ophthalmic platforms for use in ophthalmic procedures are described. The platform is supported at least in part upon a patient's face where the platform is configured to cover at least one or both eyes and further includes a conformable portion which rests upon a remainder of the patient's face. The platform may also integrate rests for the hands of the surgeon and may optionally integrate an instrument rest for allowing ready access of one or more surgical instruments to the surgeon. One or more corresponding eyelid speculums may also be integrated with the surgical platform eliminating the need for a separate speculum. An irrigation fluid trough may also be integrated with the surgical platform for collecting and diverting an irrigating fluid and the platform may optionally be used in combination with an oxygen delivery mask or nasal cannula. | 12-24-2015 |
20150363940 | Robust Anytime Tracking Combining 3D Shape, Color, and Motion with Annealed Dynamic Histograms - Velocity controllers in accordance with embodiments of the invention enable velocity estimation for tracked objects. One embodiment includes a tracker controller, including: a processor, and a memory containing: a velocity tracker application; a state space describing relationships between measured locations, calculated locations, and changes in locations, where the calculated locations in the state space correspond to unoccluded points on the surface of the tracked object; wherein the processor is configured by the velocity tracker application to: pre-process the state space to identify a tracked object; estimate a velocity of the tracked object using a location history calculated from the measured locations of the tracked object within the state space and a motion model calculated from the state space; and return the velocity of the tracked object. | 12-17-2015 |
20150356500 | Systems, Methods, and Devices for Monitoring Blood Products During Portable Storage and Transport - Systems and methods for monitoring blood products using portable storage units (“PSUs”) are disclosed. A PSU can be configured to communicate with a blood product management server for monitoring blood products. In many embodiments, a PSU can include a cooling mechanism to control the internal temperature of the PSU, a RFID reader configured to scan at least one RFID tag associated with at least one blood product, a processor, and a memory containing a PSU application, wherein the PSU application configures the processor to: determine a temperature profile for the at least one blood product, generate health status information for the at least one blood product based upon the blood product's temperature profile, generate a user interface that includes information regarding the at least one blood product's health status information, and transmit the at least one blood product's health status information to the blood product management server. | 12-10-2015 |
20150356238 | Scoring the Deviation of an Individual with High Dimensionality from a First Population - Techniques for scoring deviations of individuals from a population include obtaining profile data for each individual in a first population and from a subject drawn from a second population. The profile data indicates values for each of multiple parameters. Within the first population, a first neighbor and a second neighbor are determined, different from the subject and each other. A first distance of a vector distance metric between the subject and the first neighbor is less than a distance between the subject and any other individual of the first population. A second distance between the first neighbor and the second neighbor is less than a distance between the first neighbor and any other individual of the first population. A deviation of the subject from the first population is determined based on a ratio of the first distance divided by the second distance and presented on a display device. | 12-10-2015 |
20150343201 | DEVICE AND METHOD FOR POSITIONING AN ELECTRODE IN TISSUE - A device for positioning an electrode in tissue includes: a lead body having a distal portion; an electrode array coupled to the lead distal portion; an anchoring element having an anchor tip and being operable in a first configuration in which the anchor tip is retracted within the lead and in a second configuration in which the anchor tip is extended outside the lead and configured to fixate within the tissue; and a displacement mechanism that is actuated to bias the electrode array or the anchoring element toward the tissue. A method for positioning an electrode in tissue includes: navigating, to the tissue, a lead with an electrode array, an anchoring element with a distal anchor tip, and a displacement mechanism; biasing the electrode array and anchoring element towards the tissue with the displacement mechanism; and deploying the anchoring element, and verifying fixation of the anchor tip within the tissue. | 12-03-2015 |
20150315552 | Inhibition of AXL Signaling in Primary Tumor Therapy - Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6. | 11-05-2015 |
20150306350 | Anchoring Nerve Block Catheter - The invention relates to medical devices and, particularly, catheter medical devices. In an aspect is a nerve block catheter system comprising a dual-sheath catheter comprising an inner sheath and an outer sheath, wherein distal ends of the sheaths are connected, the inner sheath defines a fluid delivery lumen, and the outer sheath comprises a tissue lock movable between a collapsed position and an extended position, wherein the tissue lock forms a reversible tissue anchor when in the extended position, and an actuator connected to the proximate end of the catheter and configured to activate the tissue lock by sliding the outer sheath length-wise relative to the inner sheath. | 10-29-2015 |
20150280129 | STRETCHABLE DEVICE, METHOD OF MANUFACTURING THE SAME, AND ELECTRONIC APPARATUS INCLUDING STRETCHABLE DEVICE - Provided are stretchable devices, methods of manufacturing the same, and electronic apparatuses including the stretchable devices. A stretchable device may include first and second material layers, each including an elastomeric polymer, and an organic layer that is disposed between the first and second material layers. The organic layer may include an organic semiconductor. As least one electrode element may be embedded in at least one of the first and second material layers. The at least one electrode element may be electrically connected to the organic layer. The stretchable device may be stretchable in a direction parallel to the organic layer. The stretchable device may be a transistor, and may further include a gate electrode. | 10-01-2015 |
20150273053 | Methods to enhance T-cell mediated immune response - The present invention provides methods for restoring or enhancing T cell mediated immune response in individuals of middle and advanced age. | 10-01-2015 |
20150272993 | Combined Organ and Hematopoietic Cells For Transplantation Tolerance of Grafts - Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance. | 10-01-2015 |
20150257908 | INDWELLING BODY LUMEN EXPANDER - Indwelling body lumen expanders which allow for the maintenance and patency of a body lumen, such as the prostatic urethra to relieve urethral obstruction, are described. Because the one or more expanders are configured to be relatively larger in diameter than the diameter of the body lumen, the expanders may become invaginated into the lumen wall thus enabling the prostheses to avoid fluid exposure which in turn prevent the prostheses from becoming encrusted or calcified. | 09-17-2015 |
20150243867 | DEVICE AND METHOD FOR THERMOELECTRONIC ENERGY CONVERSION - A thermoelectronic energy converter device ( | 08-27-2015 |
20150219653 | 2,7-DISUBSTITUTED CEPHALOSPORIN DERIVATIVES AS BETA-LACTAMASE SUBSTRATES AND METHODS FOR THEIR USE FOR THE DIAGNOSIS OF TUBERCULOSIS - β-Lactamase substrates and methods for using the substrates to detect β-lactamase and to diagnose tuberculosis. | 08-06-2015 |
20150201832 | METAMORPHOPSIA TESTING AND RELATED METHODS - A visual distortion test is disclosed using a sequence of binary interactions with a mobile device, in which segments of the grid having no distortions are eliminated, and the segments with distortions are divided into smaller segments for further analysis. The test can quantify the visual distortion using a decreased number of steps, compared to sequential analysis of all the segments of the grid. The binary interaction or input to the mobile device is also easier for patients than graphic interactions with a conventional Amsler Grid. Early detection of changes in the visual distortion can enable the healthcare provider to individualize treatment, helping to prevent vision loss while minimizing visits to the office, discomfort, and expense. | 07-23-2015 |
20150196917 | METHODS AND APPARATUS FOR NUCLEIC ACID SYNTHESIS USING OLIGO-TEMPLATED POLYMERIZATION - A method and apparatus for synthesizing nucleic acid (NA) by sequential addition of nucleotide triphosphates to a single stranded NA molecule (growing-chain) is described. The growing-chain is annealed to an oligonucleotide, wherein the 3′ end of the oligonucleotide is complementary to the 3′ end of the growing-chain and wherein the protruding 5′ end of the oligonucleotide has the correct sequence to serve as a template for the growing-chain to produce a NA product. The growing-chain is then brought into contact with a polymerase in the presence of one or more nucleotide triphosphates under conditions permitting the polymerase to catalyze addition of one or more nucleotide triphosphates to the 3′ end of the growing-chain using the annealed oligonucleotide as a template. After polymerization has occurred, the annealed growing-chain and oligonucleotide are denatured so that the steps can be repeated until the NA product of desired length is synthesized. | 07-16-2015 |
20150191753 | METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS THROUGH ENZYME RELOCATION - Genetically manipulated cells, lysates of such cells, systems, and methods of use thereof are provided, where one or more enzymes in a pathway of interest are genetically modified to incorporate a peptide sequence that provides for relocation of the protein, e.g., to the periplasm, so as to sequester the enzyme, and where the enzyme controls flux in the pathway of interest. | 07-09-2015 |
20150191717 | SIMULTANEOUS EXTRACTION AND SEPARATION OF RNA AND DNA FROM SINGLE CELLS USING ELECTROPHORETIC TECHNIQUES - Devices and methods for preparing RNA and DNA from single cells are disclosed. In particular, the invention relates to a method of simultaneously extracting RNA and DNA from single cells and separating the nucleic acids electrophoretically. An electric field is used to lyse a single target cell, such that the plasma membrane is selectively disrupted without lysing the nuclear membrane. Cytoplasmic RNA is separated from the nucleus by performing isotachophoresis (ITP) in the presence of a sieving matrix that preferentially reduces the mobility of the nucleus. During ITP, the cytoplasmic RNA accumulates at an ITP interface between leading and trailing electrolytes and can later be extracted free of nuclear DNA. The method can be performed in a microfluidic device that fully automates all steps of the process. | 07-09-2015 |
20150191489 | IMIDAZO BICYCLIC IMMINIUM COMPOUNDS AS ANTITUMOR AGENTS - Compounds of formula I: | 07-09-2015 |
20150174202 | Methods and Compositions for Modulating Beta Cell Proliferation - Methods and compositions are provided for modulating pancreatic islet β cell proliferation. Aspects of the methods include promoting β cell proliferation by providing agents that promote PDGFR signaling, or inhibiting β cell proliferation by providing agents that inhibit PDGFR signaling. These methods find a number of uses, including, for example, in the treatment of diabetes and human islet diseases. Also provided are reagents and kits thereof that find use in practicing the subject methods. | 06-25-2015 |
20150157690 | Amyloid Beta Peptides as a Therapy for Inflammation - The invention provides methods for treating inflammatory diseases by administering to the subject an effective amount of an amyloid beta peptide, where the dose is effective to suppress or prevent initiation, progression, or relapses of disease, including the progression of established disease. | 06-11-2015 |
20150156402 | IMAGING ARRANGEMENTS AND METHODS THEREFOR - Image data is processed to facilitate focusing and/or optical correction. According to an example embodiment of the present invention, an imaging arrangement collects light data corresponding to light passing through a particular focal plane. The light data is collected using an approach that facilitates the determination of the direction from which various portions of the light incident upon a portion of the focal plane emanate from. Using this directional information in connection with value of the light as detected by photosensors, an image represented by the light is selectively focused and/or corrected. | 06-04-2015 |
20150155508 | SOLAR CELL HAVING ORGANIC NANOWIRES - Example embodiments relate to a solar cell including organic nanowires. The solar cell may include a photoelectric conversion layer formed of a p-type material including an organic material and an n-type material including organic nanowires. | 06-04-2015 |
20150133317 | IDENTIFICATION OF POLYNUCLEOTIDES ASSOCIATED WITH A SAMPLE - Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest. | 05-14-2015 |
20150132774 | FLUORESCENT PROTEIN VOLTAGE SENSORS FOR MEASURING MEMBRANE POTENTIAL AND IMAGING HIGH-FREQUENCY NEURONAL ELECTRICAL ACTIVITY - Fluorescent protein voltage sensors for measuring membrane potential and imaging high-frequency neuronal electrical activity are disclosed. In particular, the invention relates to engineered protein voltage sensors that comprise a voltage-sensing domain comprising four transmembrane domains linked to a circularly permuted fluorescent protein, which is inserted into the extracellular loop between the third (S3) and fourth (S4) transmembrane segments of the voltage-sensing domain. Such fluorescent protein voltage sensors can be used for measuring the electrical activity of neurons, including single action potentials, trains of action potentials, and subthreshold potential changes and, in particular, for imaging high-frequency neuronal electrical activity. Additionally, fluorescent protein voltage sensors can be used for a variety of other purposes, including measuring the membrane potential of any cell, including other excitable cells such as cardiac cells and endocrine cells, and for screening agents that target ion channels for their effects on membrane potential. | 05-14-2015 |
20150125890 | IMAGING AND EVALUATING EMBRYOS, OOCYTES, AND STEM CELLS - Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 05-07-2015 |
20150104793 | NON-INVASIVE FETAL GENETIC SCREENING BY DIGTAL ANALYSIS - The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital analysis is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents. | 04-16-2015 |
20150099150 | ELECTROCHEMICAL SYSTEMS AND METHODS FOR HARVESTING HEAT ENERGY - Electrochemical systems for harvesting heat energy, and associated electrochemical cells and methods, are generally described. | 04-09-2015 |
20150073258 | Methods for detecting abnormalities and degenerative processes in soft tissue using magnetic resonance imaging - The present invention provides methods to detect degenerative processes and abnormalities in soft tissues at high spatial resolution, high signal-to-noise ratio and short scanning times, based on quantitative tissue properties. These methods might provide a useful tool to detect and assess abnormalities in soft tissues and to monitor disease progression. | 03-12-2015 |
20150072876 | SELF-DIRECTED METHOD FOR CELL-TYPE IDENTIFICATION AND SEPARATION OF GENE EXPRESSION MICROARRAYS - Gene expression analysis is generally performed on heterogeneous tissue samples consisting of multiple cell types. Current methods developed to separate heterogeneous gene expression rely on prior knowledge of the cell-type composition and/or signatures—these are not available in most public datasets. We present a novel method to identify the cell-type composition, signatures and proportions per sample without need for a priori information. The method was successfully tested on controlled and semi-controlled datasets and performed as accurately as current methods that do require additional information. As such, this method enables the analysis of cell-type specific gene expression using existing large pools of publically available microarray datasets. | 03-12-2015 |
20150070177 | System and Method for Detecting and Preventing Drowsiness - A system for preventing drowsiness in a driver by employing a thermal grill. The system includes a detection module and an intervention module. The detection module monitors a driver's parameters to determine whether the driver is drowsy. If the driver is determined to be drowsy, the intervention module activates a thermal grill with interlaced hot and cold regions. This activation causes the hot regions to approach one temperature and the cold regions to approach another. Additionally, this activation leads to an uncomfortable sensation for the driver, alerts the driver, and prevents the driver from getting drowsy. | 03-12-2015 |
20150064751 | METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS THROUGH PROTEASE MANIPULATION - The embodiments described herein pertain to cells, and methods for preparing cells, that can be used as biocatalysts by altering enzymes that compete for a substrate or product of a pathway of interest such that the targeted enzyme is sensitive to a site-specific protease, which protease is expressed but relocated in the cell to a site where it is not in contact with the targeted enzyme in the intact cell. Upon cell lysis, the protease contacts the target enzyme, which is then inactivated by protease cleavage. | 03-05-2015 |
20150057267 | Methods and Compositions for Treating Viral Diseases - The invention provides a method for treating viral infections and coinfections through the use of inhibitory agents that prevent a unique viral structural protein motifs from binding to host proteins from the clathrin adaptor proteins family and subsequently preventing viral replication. | 02-26-2015 |
20150056162 | Therapeutic IL-13 Polypeptides - Variant IL-13 polypeptides are provided, which are engineered to have one or more of the following properties: (a) altered affinity for IL-13Rα2, relative to the native human IL-13 protein; (b) altered affinity for IL-13Rα1 relative to the native human IL-13 protein; (c) a disruption in the binding site for IL-4Rα relative to the native human IL-13 protein. | 02-26-2015 |
20150042329 | DYNAMIC CONTRAST ENHANCED MAGNETIC RESONANCE IMAGING WITH HIGH SPATIAL-TEMPORAL RESOLUTION - A method of providing dynamic magnetic resonance imaging (MRI) of an object in an MRI system is provided. A magnetic resonance excitation from the MRI system is applied to the object. A magnetic resonance signal is read out through k-space for a plurality of regions with two or three spatial dimensions and a temporal dimension, wherein the read out is pseudo-randomly undersampled in the spatial frequency dimensions and the temporal dimension providing k-space data that is pseudo-randomly undersampled in the spatial frequency dimensions and the temporal dimension. The readout data is used to create a sequential series of spatial frequency data sets by generating interpolated data in the spatial frequency dimensions and the temporal dimension. The sequential series of spatial frequency data sets is used to create temporally resolved spatial images. | 02-12-2015 |
20150040249 | Non-Human Animal Models of Depression and Methods of Use Thereof - The disclosure provides non-human optogenetic animal models of depression. Specifically, non-human animals each expresses a light-responsive opsin in a neuron of the animal are provided. The animal models are useful for identifying agents and targets of therapeutic strategies for treatment of depression. Examples of using the non-human animals expressing light-responsive opsin including Halorhodopsin family of light-responsive chloride pumps and Channelrhodopsin family of light-responsive cation channel proteins are described. | 02-05-2015 |
20150032750 | METHOD FOR DISCOVERING RELATIONSHIPS IN DATA BY DYNAMIC QUANTUM CLUSTERING - Data clustering is provided according to a dynamical framework based on quantum mechanical time evolution of states corresponding to data points. To expedite computations, we can approximate the time-dependent Hamiltonian formalism by a truncated calculation within a set of Gaussian wave-functions (coherent states) centered around the original points. This allows for analytic evaluation of the time evolution of all such states, opening up the possibility of exploration of relationships among data-points through observation of varying dynamical-distances among points and convergence of points into clusters. This formalism may be further supplemented by preprocessing, such as dimensional reduction through singular value decomposition and/or feature filtering. | 01-29-2015 |
20150030805 | COMPOSITE BI-ANGLE AND THIN-PLY LAMINATE TAPES AND METHODS FOR MANUFACTURING AND USING THE SAME - Various embodiments provide a bi-angle pliable tape for use in forming a composite laminate structure. The bi-angle pliable tape comprises: a longitudinal axis extending in a unidirectional machine direction; a first ply comprising fibers extending in a first orientation, the first orientation being offset relative to the longitudinal axis at a first angle of less than 30°; and a second ply comprising fibers extending in a second orientation, the second orientation being opposite the first orientation relative to the unidirectional machine direction. The first ply and the second ply are further secured substantially adjacently relative to one another by one or more yarns so as to provide a non-crimped configuration such that the bi-angle tape defines a pliable structure. Corresponding composite laminate structures and methods for making the same are provided. Composite laminate integrated bulkheads, containment rings, and penetration resistant articles and corresponding methods of making the same are provided. | 01-29-2015 |
20150029388 | IMAGING ARRANGEMENTS AND METHODS THEREFOR - Image data is processed to facilitate focusing and/or optical correction. According to an example embodiment of the present invention, an imaging arrangement collects light data corresponding to light passing through a particular focal plane. The light data is collected using an approach that facilitates the determination of the direction from which various portions of the light incident upon a portion of the focal, plane emanate from. Using this directional information in connection with value of the light as detected by photosensors, an image represented by the light is selectively focused and/or corrected. | 01-29-2015 |
20150018725 | SYSTEMS AND METHODS FOR TREATING PANCREATIC CANCER - A method of treating pancreatic cancer includes: inserting a device into a stomach or a duodenum; securing at least a portion of the device in position relative to the stomach or the duodenum; and delivering ultrasonic energy from the device to treat a target site in a pancreas. | 01-15-2015 |
20140374581 | METHOD AND STRUCTURE FOR PLASMONIC OPTICAL TRAPPING OF NANO-SCALE PARTICLES - Methods and article for optically trapping nano-sized objects by illuminating a coaxial plasmonic aperture are disclosed. | 12-25-2014 |
20140370522 | DETECTION OF PROTEIN TRANSLOCATION BY BETA-GALACTOSIDASE REPORTER FRAGMENT COMPLEMENTATION - Methods and compositions are provided for detecting molecular translocations, particularly protein translocations within and between sub-cellular compartments, using at least two components that exhibit a localization-dependent difference in complementation activity. In particular, alpha-complementing β-galactosidase fragments are provided. These β-galactosidase reporter fragments display significantly enhanced enzymatic activity when one fragment is localized in a membrane. Methods for carrying out no-wash ELISA assays based on the reporter component system are also provided. | 12-18-2014 |
20140370001 | IgE ANTIBODIES FOR THE INHIBITION OF TUMOR METASTASIS - The present invention provides novel IgE antibodies useful for inhibiting or preventing metastatic cancer. Also provided are methods to inhibit tumor metastasis by modulating the activity of at least one non-tumor cell, treating a patient to inhibit or prevent tumor metastases of a primary solid tumor, treating metastatic carcinoma, reducing metastasis of carcinoma cells, and reducing the growth kinetics of a primary solid tumor or a metastasized cell or tumor. | 12-18-2014 |
20140363917 | DEPLETION-MODE FIELD-EFFECT TRANSISTOR-BASED PHOTOTRANSISTOR - A depletion-mode phototransitor is disclosed. The phototransistor having a substrate, a gate, a source, a drain and a channel. The source, drain and channel are doped to be the same type of semiconductor. The substrate can be made of silicon and/or germanium. The gate can be made of either aluminum or polysilicon. | 12-11-2014 |
20140360861 | CATALYSIS CONTROLLED BY INTERFACIAL ELECTRIC FIELDS - A method for controlling selectivity or turnover frequency of a catalyst is provided. The catalyst is provided between a first electrode and a second electrode spaced apart from the first electrode, wherein the first electrode has an insulating layer on a first side of the first electrode and the second electrode has an insulating layer on a first side of the second electrode wherein where the first side of the first electrode and the first side of the second electrode are between the first electrode and second electrode. A fluid solution that contains a salt electrolyte and a substrate for a catalytic reaction is provided between the electrodes. A voltage is provided between the first electrode and second electrode. | 12-11-2014 |
20140356455 | PLURIPOTENT CELL LINES AND METHODS OF USE THEREOF - Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation of a gene of interest are provided. | 12-04-2014 |
20140356286 | Polypeptides Targeting Vascular Endothelial Growth Factor Receptor-2 and Alpha V Beta 3 Integrin - Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization. | 12-04-2014 |
20140350327 | Device and method for interfering with sympathetic chain signaling for attenuating hot flashes, post-traumatic stress disorder, pain and dysautonomia - Provided herein are a device and method for attenuating posttraumatic stress syndrome, menopause symptoms, dysautonomia and pain by interfering with sympathetic chain signaling, particularly by blocking stellate ganglion conduction. | 11-27-2014 |
20140350235 | IN SITU OLIGONUCLEOTIDE SYNTHESIS ON A PARAMAGNETIC SUPPORT - A novel method for attaching oligonucleotides to a paramagnetic solid support is disclosed. Conventional methods of attachment require that oligonucleotides be pre-synthesized with specific end modifications, which is laborious and expensive. Instead, we attached oligonucleotides to paramagnetic beads by direct synthesis of the oligonucleotides on the surface of the beads. An external magnet was used to hold the paramagnetic beads in place during solid-phase synthesis. A magnetic force was applied directly to the beads to prevent their loss, in particular, during reagent purge-to-waste steps that involved high-pressure drain or vacuum. This method can be adapted for use in any laboratory working with conventional synthesis automation, and can be employed, for example, with single columns and multi-well titer plates. | 11-27-2014 |
20140343045 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof - The present disclosure provides compounds that function as modulators of aldehyde dehydrogenase (ALDH) enzymatic activity, as well as compositions and formulations comprising the compounds. The present disclosure provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. | 11-20-2014 |
20140340688 | SLOW-LIGHT SENSOR UTILIZING AN OPTICAL FILTER AND A NARROWBAND OPTICAL SOURCE - An optical device and a method of using an optical filter are provided. The optical device includes an optical filter and a narrowband optical source. The optical filter has a refractive index that varies along a length of the optical filter. The narrowband optical source is in optical communication with the optical filter and is configured to generate light having a wavelength at or in the vicinity of at least one of a wavelength corresponding to a local transmission maximum and a wavelength corresponding to a maximum slop of the group index spectrum of the optical filter. | 11-20-2014 |
20140329708 | Methods and Compositions for Determining a Graft Tolerant Phenotype in a Subject - Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression of at least 5 genes in a sample from the subject, e.g., a blood sample, is assayed to obtain a gene expression result for the at least 5 genes. The obtained gene expression result for the at least 5 genes is then employed to determine whether the subject has a graft tolerant phenotype. Also provided are compositions, systems and kits that find use in practicing the subject methods. The methods and compositions find use in a variety of applications, including the determination of an immunosuppressive therapy regimen. | 11-06-2014 |
20140329691 | Noninvasive Diagnosis of Fetal Aneuploidy by Sequencing - Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated. By counting the number of sequence tags mapped to a predefined window in each chromosome, the over- or under-representation of any chromosome in maternal plasma DNA contributed by an aneuploid fetus can be detected. This method does not require the differentiation of fetal versus maternal DNA. The median count of autosomal values is used as a normalization constant to account for differences in total number of sequence tags is used for comparison between samples and between chromosomes. | 11-06-2014 |
20140329378 | GATE ELECTRODE WITH DEPLETION SUPPRESSION AND TUNABLE WORKFUNCTION - Semiconductor device performance is improved via a gate structure having a tunable effective workfunction and reduced gate depletion effects. According to an example embodiment, the design threshold voltage of a semiconductor device is adjusted in a manner that includes providing a gate having a workfunction that enables operation of the semiconductor device at a selected voltage. The gate is formed having two different conductive materials with different electric workfunctions that both significantly contribute to the overall workfunction of the gate. The relative composition, thickness, and arrangement of each of the two conductive materials is selected to attain a gate electrode workfunction that is different than the workfunctions of each of the two layers and that sets the threshold voltage of the semiconductor device. The adjustability of the effective workfunction of the gate electrode can be applied to a variety of semiconductor devices. The ability to reduce gate depletion effects also provides enhanced device current drive. | 11-06-2014 |
20140324133 | Materials and Approaches for Optical Stimulation of the Peripheral Nervous System - A variety of methods, devices, systems and arrangements are implemented for stimulation of the peripheral nervous system. Consistent with one embodiment of the present invention, method is implemented in which light-responsive channels or pumps are engineered in a set of motor units that includes motor units of differing physical volumes. Optical stimuli are also provided to the light-responsive channels or pumps at an optical intensity that is a function of the size of motor units to be recruited. In certain implementations, the intensity of the optical stimuli is increased so as to recruit increasingly larger motor units. | 10-30-2014 |
20140323849 | Optogenetic Magnetic Resonance Imaging - Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell population in a first region of a brain to express light-responsive molecules. Using a light pulse, the light-responsive molecules in the target neural cell population are stimulated. Multiple regions of the brain are scanned via magnetic resonance imaging. The scans allow for observation of a neural reaction in response to the stimulation in at least one of the multiple regions of the brain. | 10-30-2014 |
20140323555 | tRNA DERIVED SMALL RNAs (tsRNAs) INVOLVED IN CELL VIABILITY - The present invention features compositions and methods relating to tRNA-derived small RNAs (tsRNAs). Provided herein are oligonucleotide compositions that are complementary to tsRNAs, in particular leuCAGtsRNA, and methods of using the oligonucleotides for the regulation of respective tsRNA. Further provided are methods of inducing apoptosis through the inhibition of leuCAGtsRNA. | 10-30-2014 |
20140323524 | Anti-Proliferative Compounds and Methods for Using the Same - Disclosed herein are anti-proliferative compounds which find use in inhibiting the growth of cancer cells. Also provided herein are methods for using these compounds for inhibiting growth of cancer cells. Also provided herein are methods for using these compounds for treating a subject for hyperproliferative conditions, including without limitation the treatment of hematopoietic cancers. | 10-30-2014 |
20140323520 | Compositions and Methods for Increasing Proliferation of Adult Salivary Stem Cells - The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (ALDH) agonist. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells in an indi vidual undergoing radiotherapy for head and neck cancer. | 10-30-2014 |
20140322278 | Modulation of Tissue Transglutaminase Activation in Disease - Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the activation of TG2 associated with enteric inflammatory disorders, which disorders may include celiac disease, irritable bowel syndrome, Crohn's Disease, dermatitis herpetiformis, and the like. In other embodiments of the invention, methods are provided for reducing undesirable paracellular transport in enteric tissues, in particular the paracellular transport of molecules greater than about 500 mw, e.g. peptides, including without limitation immunogenic gluten peptides. | 10-30-2014 |
20140319461 | SINGLE-WALLED CARBON NANOTUBE-BASED PLANAR PHOTODECTOR - A single-walled carbon nanotube-based planar photodetector includes a substrate; a first electrode and a second electrode disposed on the substrate and spaced apart from each other; a plurality of single-walled carbon nanotubes, each of the plurality of single-walled carbon nanotubes contacting the first electrode and the second electrode; and an adsorbent attached to a surface of at least one of the plurality of single-walled carbon nanotubes, wherein the adsorbent is capable of doping the at least one of the plurality of single-walled carbon nanotubes by photo-excitation. | 10-30-2014 |
20140314734 | COMPOSITIONS AND METHODS FOR SPECIFIC REGULATION OF PYRUVATE DEHYDROGENASE KINASE - A peptide composition is provi'deo!which specifically inhibits the ability of δ protein kinase C (δPKC) to phosphor/late pyruvate dehydrogenase kinase (PDK) under ischemic conditions. The peptide composition is useful for treating or reducing tissue damage resulting from ischemia and/or reperfusion. | 10-23-2014 |
20140309705 | System for Optical Stimulation of Target Cells - Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing a NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell. | 10-16-2014 |
20140308801 | Anything on Glass - Bonding of one or more semiconductor layers to a glass substrate is facilitated by depositing spin-on-glass (SOG) on the top of the semiconductor layers. The SOG is then bonded to the glass substrate, and after that, the original substrate of the semiconductor layers is removed. The resulting structure has the semiconductor layers disposed on the glass substrate with a layer of SOG sandwiched between. Bonding is always between glass and glass, and is independent of the composition of the target layers. Thus, it can provide “anything on glass”. For example, X-on-insulator (XOI), where X can be silicon, germanium, GaAs, GaN, SiC, graphene, etc. The spin-on-glass also helps with the surface roughness requirement. | 10-16-2014 |
20140308244 | Combination Therapy for Treatment of Inflammatory Demyelinating Disease - Provided herein include combination therapies for the treatment of neurological inflammatory diseases, such as, for example, demyelinating autoimmune diseases, such as multiple sclerosis and neuromyelitis optica, etc. In various aspects and embodiments, the methods may include administering to a patient an effective dose of an inhibitor of an angiotensin-converting enzyme (ACE) in combination with one or more second compounds, In one aspect, provided is a method of treating a demyelinating autoimmune disease (such as multiple sclerosis) that includes administering to a patient an effective dose of an inhibitor of an angiotensin-converting enzyme (ACE) in combination with one or more compounds selected from the group consisting of a cytokine, a vitamin B, dimethyl fumarate (DMF, also referred to as BG-12) and fingolimod (Gilenya). | 10-16-2014 |
20140296210 | PHARMACOLOGICAL TREATMENT OF COGNITIVE IMPAIRMENT - Methods for treating an individual to improve cognitive function are provided. In the subject methods, an effective amount of a noncompetitive GABA | 10-02-2014 |
20140291163 | CATALYSTS FOR LOW TEMPERATURE ELECTROLYTIC CO2 REDUCTION - A method for electrochemically reducing CO | 10-02-2014 |
20140276022 | MICROPOSITIONER AND HEAD HOLDER FOR COCHLEAR ENDOSCOPY - An apparatus for cochlear endoscopy is provided, comprising a noninvasive head holder with a frame to attach to a head, an otologic tool for examining or operating on an ear, and a manipulator for moving the otologic tool with a translation precision of better than or equal to 0.5 mm. The otologic tool comprises an endoscope. | 09-18-2014 |
20140275228 | METHODS FOR TREATING DENERVATION-INDUCED MUSCLE ATROPHY - The present invention provides methods for the treatment of denervation-induced skeletal muscle atrophy, and generally, denervation-induced skeletal muscle degeneration diseases using agents that decrease the activity of mammalian target of rapamycin and/or the activity of at least one of the Forkhead Box Transcription Factors 1, 3 and 4. | 09-18-2014 |
20140274904 | INHIBITORS OF MITOCHONDRIAL FISSION AND METHODS OF USE THEREOF - The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of reducing abnormal mitochondrial fission in a cell. Also provided are methods for designing and validating mitochondrial fission inhibitor constructs and peptides, including but not limited to, evaluating the effects of the constructs and peptides on Drp1 GTPase activity, binding of Drp1 to Fis1, reduction of mitochondrial damage, reduction in cell death, inhibition of mitochondrial fragmentation in a cell under pathological conditions, and reduced loss of neurites in primary dopaminergic neurons in a Parkinsonism cell culture. | 09-18-2014 |
20140274782 | AFFINITY REAGENTS AND METHODS FOR DETECTION, PURIFICATION, AND PROTEOMIC ANALYSIS OF METHYLATED PROTEINS - Methyl-lysine affinity reagents created by engineering the 3×MBT methyl-lysine binding domain repeat of lethal (3) malignant brain tumor-like protein 1 (L3MBTL1) are disclosed. In particular, the invention relates to affinity reagents and affinity chromatography media comprising the 3×MBT domain repeat and methods of using such affinity reagents in detection, purification, and proteomic profiling of methylated proteins and peptides. | 09-18-2014 |
20140271683 | Therapeutic and Diagnostic Methods for Manipulating Phagocytosis Through Calreticulin and Low Density Lipoprotein-Related Receptor - Therapeutic and diagnostic methods are provided, which methods relate to the expression of calreticulin on cancer cells and hematopoietic cells. | 09-18-2014 |
20140271479 | OPTOGENETIC CONTROL OF INPUTS TO THE VENTRAL TEGMENTAL AREA - The present disclosure provides a method of inducing or modulating reward- or aversive-related behaviors in animals using light-responsive opsins. The present disclosure provides methods of identifying or screening compounds that may be used to treating mental disorders, or are relevant to disrupt or improve reward- or aversive related behaviors. | 09-18-2014 |
20140271469 | CYSTINE KNOT PEPTIDES THAT BIND ALPHA-V-BETA-6 INTEGRIN - Disclosed are peptides comprising a molecular scaffold portion and a loop portion that binds to integrin α | 09-18-2014 |
20140266191 | DISTORTION-FREE MAGNETIC RESONANCE IMAGING NEAR METALLIC IMPLANTS - A method for 3D magnetic resonance imaging (MRI) with slice-direction distortion correction is provided. One or more selective cross-sections with a thickness along a first axis are excited using a RF pulse with a bandwidth, wherein a selective cross-section is either a selective slice or selective slab. A refocusing pulse is applied to form a spin echo. One or more 2D encoded image signals are acquired with readout along a second axis and phase encoding along a third axis, wherein the data long the phase encoded first and third axes is acquired with an under sampling scheme. Slice-direction distortion is corrected by resolving the position by using phase encoding. | 09-18-2014 |
20140263963 | VOLUME IMAGING WITH ALIASED VIEWS - Images are detected in a manner that addresses various challenges as discussed herein. As may be consistent with one or more embodiments, aspects are directed to an apparatus having sets of photosensors that detect light rays received at different angles from a specimen via a microlens array, with the light rays detected by each set of photosensors representing an aliased view of the specimen. An output indicative of aliased views of the specimen is provided. Certain embodiments further include a logic circuit that processes the output and generates a deconvolved volume image by combining aliased views of the specimen as detected by the photosensors. | 09-18-2014 |
20140263843 | Universal Spacecraft Architecture - A system and method for assembling a spacecraft in orbit using orbiting modules. Each module has a function such as fuel, transport, communication and payload. A command and control system and logic assembles the modules for missions. After use the modules may be disassembled and parked in orbit. The assembly of modules for a mission is controlled by a logic that assesses the mission requirement, module status and capability and matches resources. The referenced command and control system and logic is used to maneuver vehicles and modules and controls missions. Communications between and among modules and signal sources are facilitated by a language protocol that has a library of commands and responses accessible by signals using divergent communications languages. The protocol also converts common programming language to a language compatible for use by a recipient module, logic or communication satellite or ground station. | 09-18-2014 |
20140257538 | METHODS FOR ANALYZING AND PROVIDING FEEDBACK FOR IMPROVED POWER GENERATION IN A GOLF SWING - This invention relates to methods for optimizing a golf swing by measuring and providing feedback on a combination of various key parameters of a subject's movement to both generate more power and reduce injury. | 09-11-2014 |
20140255424 | BIOMARKERS OF AGING FOR DETECTION AND TREATMENT OF DISORDERS - Provided are methods of diagnosis, prognosis, and monitoring of aging using biomarkers that have been discovered to be linked to biological aging process. Methods for increasing neural cell regeneration and cognitive function are also provided. The methods are, at least in part, based on a discovery that altered expression patterns of certain biological markers are associated with biological aging processes. These markers comprise at least Eotaxin/CCL11, β2-microglobulin, MCP-1 and Haptoglobulin, increased expression of which has been shown to be associated with increase in biological aging process. | 09-11-2014 |
20140255361 | ESTROGEN-RECEPTOR BASED LIGAND SYSTEM FOR REGULATING PROTEIN STABILITY - Disclosed herein are systems, methods and compositions for rapidly and reversibly destabilizing a target protein in vitro or in vivo, in the presence or absence of a cell-permeable, synthetic molecule or ligand. | 09-11-2014 |
20140254704 | DYNAMIC DIGITAL COMMUNICATION SYSTEM CONTROL - Control of a digital communication system having a plurality of communication lines on which signals are transmitted and received is implemented using a variety of methods and systems. According to one embodiment of the present invention, a method is implemented where the signals are affected by interference during transmission and each of the communication lines has at least one transmitter and at least one receiver. A model is created of the interference characteristics due to the signals carried on the communication lines. Interference characteristics for a line are determined based on the model and actual signals carried on other communication lines different from the line for which the characteristics are being determined. Actual interference is compensated for on the communication line using the determined interference characteristics. | 09-11-2014 |
20140249295 | LIGHT-INDUCIBLE SYSTEM FOR REGULATING PROTEIN STABILITY - Disclosed herein are a light-inducible system and method for rapidly and reversibly modulating protein stability and function. This system and method employs conditionally stable protein domains that regulate the degradation of a fusion protein depending upon the presence or absence of a particular light source. | 09-04-2014 |
20140242600 | IMAGING THE HETEROGENEOUS UPTAKE OF RADIOLABELED MOLECULES IN SINGLE LIVING CELLS - A radioluminescence microscopy system and method for imaging the distribution of radiolabeled molecules in live cell cultures and tissue sections. Cells are grown and incubated with radiolabeled molecules on a scintillator plate or a scintillator plate is placed adjacent to the cells after incubation. Scintillation light produced by decay of radiolabeled molecules inside, bound to, or surrounding the cells, is recorded on an imaging device. Fluorescence microscopy of the same cells with other types of molecules of interest that are labeled with different fluorophores can be conducted concurrently and the biological activity of the labeled molecules can be correlated. | 08-28-2014 |
20140242155 | Compounds, Compositions, Methods, and Kits Relating to Telomere Extension - Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use. | 08-28-2014 |
20140242154 | Compounds, Compositions, Methods, and Kits Relating to Telomere Extension - Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use. | 08-28-2014 |
20140236166 | BIOMARKERS FOR DISTINGUISHING BENIGN, PRE-MALIGNANT, AND MALIGNANT PANCREATIC CYSTS - Methods for prognosis and diagnosis of pancreatic cysts are disclosed. In particular, the invention relates to the use of biomarkers from pancreatic cyst fluid to aid in the diagnosis, prognosis, and treatment of pancreatic cysts. More specifically, differential expression of certain metabolites, including glucose and kynurenine, and the protein, amphiregulin, is used to distinguish benign, pre-malignant, and malignant pancreatic cysts. | 08-21-2014 |
20140235948 | METHOD FOR SINGLE-FIBER MICROSCOPY USING INTENSITY-PATTERN SAMPLING AND OPTIMIZATION-BASED RECONSTRUCTION - A method for imaging an object with resolution that exceeds the number of spatial modes per polarization in a multimode fiber is disclosed. In some embodiments, the object is interrogated with a plurality of non-spot-sized intensity patterns and the optical power reflected by the object is detected for each intensity pattern. The plurality of optical power values is then used in a non-local reconstruction based on an optimization approach to reconstruct an image of the object, where the image has resolution up to four times greater than provided by prior-art multimode fiber-based imaging methods. | 08-21-2014 |
20140235826 | OPTICALLY-BASED STIMULATION OF TARGET CELLS AND MODIFICATIONS THERETO - Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments). | 08-21-2014 |
20140235726 | METHOD OF IMPROVING COGNITION AND INCREASING DENDRITIC COMPLEXITY IN HUMANS WITH DOWN SYNDROME AND COMPOSITIONS THEREFOR - A method of improving cognition in a patient with Down syndrome, which entails administering one or more β2 adrenergic receptor agonists to the patient in an amount and with a frequency effective to improve cognition of the patient as measured by contextual learning tests | 08-21-2014 |
20140233395 | ENERGY-EFFICIENT WIRELESS COMMUNICATIONS VIA FEEDBACK - Methods and apparatus, including computer program products, are provided for energy efficient communication based on feedback. A method may include sending a first message carried by a first wireless radio channel at a first predetermined energy level; receiving, in response to the first message, a second message carried by a second wireless radio channel; comparing the first message to the second message; sending a termination message, when the comparing indicates the first message and the second message match; and sending a portion of the first message at a second predetermined energy level, when the comparing indicates the second message contains at least one error when compared to the first message. | 08-21-2014 |
20140221975 | APPARATUS AND METHODS FOR TREATING PULMONARY HYPERTENSION - A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension. In one embodiment, the method may involve advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient and using the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension. | 08-07-2014 |
20140221966 | Kalman Filter Based On-Off Switch for Insulin Pump - Techniques for controlling an insulin pump include determining values for parameters selected from a group including a first prediction time horizon, a predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a time window, and duration of the time window. A safety rule is determined based on the maximum shut off time within the duration. Glucose readings are collected up to a current time. An expected current glucose value G and glucose temporal rate of change are determined based only on the glucose readings and a Kalman filter configured for noisy glucose readings. A glucose level (Gh1) is predicted for a future time that is the prediction time horizon after the current time. A command is issued to shut off the insulin pump if it is determined both that Gh1 is less than Goff and that the safety rule is satisfied. | 08-07-2014 |
20140221468 | Compounds that Modulate Store Operated Calcium Channels - Store operated calcium channel modulating compounds, and methods for using the same, are provided. These compounds and methods find use in a variety of applications in which modulation of store operated calcium channels is desired. | 08-07-2014 |
20140219972 | TISSUE ENGINEERING USING PROGENITOR CELLS TO CATALYZE TISSUE FORMATION BY PRIMARY CELLS - Methods of regenerating tissue using progenitor cells in combination with primary cells from a target tissue are disclosed. In particular, progenitor cells catalyze proliferation and tissue production by primary cells allowing the use of fewer primary cells from a target tissue for effective tissue regeneration. Cell-based therapies combining progenitor cells and primary cells can be used for repair and regeneration of damaged tissue and organs for treating bodily injuries and degenerative diseases. For example, adipose-derived stem cells and neonatal articular chondrocytes, co-encapsulated in mixed or bilayered cultures in a hydrogel comprising chondroitin sulfate methacrylate and poly(ethylene)glycol diacrylate, generated cartilage that could be used for treatment of traumatic injuries or diseases involving cartilage degeneration. Moreover, the inventors showed that progenitor cells could be used to stimulate cartilage formation with a minimal number of primary cells, as few as 1% or less, in mixed cultures containing primary cells and progenitor cells. | 08-07-2014 |
20140217269 | COUPLED WAVEGUIDES FOR SLOW LIGHT SENSOR APPLICATIONS - An optical device includes at least one optical waveguide including a plurality of elongate portions. Light propagates sequentially and generally along the elongate portions. At least two elongate portions of the plurality of elongate portions are generally planar with one another and are adjacent and generally parallel to one another. The at least two elongate portions are optically coupled to one another such that the light is coupled between the at least two elongate portions in a direction generally perpendicular to the at least two elongate portions as the light propagates generally along the at least two elongate portions. | 08-07-2014 |
20140210469 | NONRIGID MOTION CORRECTION IN 3D USING AUTOFOCUSING WITH LOCALIZED LINEAR TRANSLATIONS - A method for providing an magnetic resonance imaging (MRI) with nonrigid motion correction of an object is provided. An MRI excitation is applied to the object. A magnetic field read out from the object using a plurality of sensor coils. Spatially localized motion estimates are obtained for each sensor coil of the plurality of sensor coils. The motion estimates are used for each sensor coil to provide motion correction. | 07-31-2014 |
20140207426 | SIMULATION OF PHENOMENA CHARACTERIZED BY PARTIAL DIFFERENTIAL EQUATIONS - Various aspects of the present disclosure are directed toward apparatus, methods, and articles of manufacture for simulating a physical phenomenon characterized by a set of partial differential equations that are reduced based on harmonic time dependence. The system of linear equations represent an operation in the differential equations, and are characterized by a coefficient matrix multiplied by an unknown column vector, with the product thereof being equal to a column vector. The system of linear equations is solved using at least one of three sets of operations. | 07-24-2014 |
20140204184 | VARIABLE IMAGING ARRANGEMENTS AND METHODS THEREFOR - Various approaches to imaging involve selecting directional and spatial resolution. According to an example embodiment, images are computed using an imaging arrangement to facilitate selective directional and spatial aspects of the detection and processing of light data. Light passed through a main lens is directed to photosensors via a plurality of microlenses. The separation between the microlenses and photosensors is set to facilitate directional and/or spatial resolution in recorded light data, and facilitating refocusing power and/or image resolution in images computed from the recorded light data. In one implementation, the separation is varied between zero and one focal length of the microlenses to respectively facilitate spatial and directional resolution (with increasing directional resolution, hence refocusing power, as the separation approaches one focal length). | 07-24-2014 |
20140200689 | QUANTUM COMPUTER AND QUANTUM COMPUTING USING ISING MODEL - For each pair of a plurality of slave lasers B for which injection synchronization is performed by a master laser M, by controlling the intensity of light exchanged between two slave lasers B and an optical path length between the two slave lasers B using a slave-to-laser intensity control unit IA and an inter-slave laser optical path length control unit IP, the magnitude and the sign of pseudo ising interaction J | 07-17-2014 |
20140192952 | MODULATING GANTRY ROTATION SPEED AND IMAGE ACQUISITION IN RESPIRATORY CORRELATED (4D) CONE BEAM CT IMAGES - A method of optimizing 4D cone beam computed tomography (4DCBCT) imaging is provided that includes using a scanner to generate projections of a target, where the projections are used to form a cone beam computed tomography (CBCT) scan of the target, where the CBCT includes a 3D image of the target, and using an appropriately programmed computer to control rotation speed of a gantry and projection acquisition of the CBCT in real-time according to a measured patient respiratory signal, where the real-time acquisition of the CBCT forms an optimized 4DCBCT image set. | 07-10-2014 |
20140187619 | TREATMENTS FOR DIABETES MELLITUS AND OBESITY - Methods of treatment in subjects suffering from diabetes mellitus or obesity are provided. The methods comprise the step of administering an active agent directly to the small intestine in the subject. In particular, the active agent may be administered directly to the duodenum in the subject. The active agents useful in the treatments described herein include analgesic agents and, in particular, antinociceptive agents such as capsaicin, resiniferatoxin, and their analogues. | 07-03-2014 |
20140187519 | BIOMARKERS FOR PREDICTING MAJOR ADVERSE EVENTS - Provided herein are diagnostic markers and uses thereof for predicting if a subject is at risk of a major adverse event. In particular, one aspect provided herein relates to methods to determine if a subject is at risk of having a major adverse effect by measuring at least 2, or at least 3 of the biomarkers beta 2 microglobulin, c-reactive protein and cystatin C. | 07-03-2014 |
20140178465 | METHOD AND USE OF NANO-SCALE DEVICES FOR REDUCTION OF TISSUE INJURY IN ISCHEMIC AND REPERFUSION INJURY - A method for protection of tissues subject to ischemic and/or reperfusion damage is provided. The method includes administering to the tissue a composition comprising nanodevices. The nanodevices can take the form of, for example, polymeric nanoparticles or lipidic nanoparticles. The nanodevices also find use in methods for reducing ischemic injury in tissue at risk of such injury, such as heart and brain tissue. | 06-26-2014 |
20140178352 | PEPTIDE INHIBITORS OF PROTEIN KINASE C - PKC V5 isozyme-specific peptides are described. The sequences and compositions comprising the sequences are useful for treating disease states associated with the PKC isozyme from which they are respectively derived. Methods of treatment, pharmaceutical formulations and methods of identifying compounds that mimic the activity of the peptides are also described. | 06-26-2014 |
20140178022 | WAVEGUIDE APPARATUSES AND METHODS - Optical fiber waveguides and related approaches are implemented to facilitate communication. As may be implemented in accordance with one or more embodiments, a waveguide has a substrate including a lattice structure having a plurality of lattice regions with a dielectric constant that is different than that of the substrate, a defect in the lattice, and one or more deviations from the lattice. The defect acts with trapped transverse modes (e.g., magnetic and/or electric modes) and facilitates wave propagation along a longitudinal direction while confining the wave transversely. The deviation(s) from the lattice produces additional modes and/or coupling effects. | 06-26-2014 |
20140177794 | SYSTEM AND METHOD FOR FOCAL SPOT DEFLECTION - An X-ray tube and methods for imaging are disclosed. The X-ray tube includes an emitter configured to generate an electron beam. Further, the X-ray tube includes a target configured to generate X-rays in response to the electron beam, where a target surface includes at least a first region having a first elevation and a second region having a second elevation different from the first elevation. The X-ray tube also includes a detector configured to generate projection data based on the X-rays and a computing device coupled to the emitter, the detector and/or the target. The computing device is configured to deflect a focal spot on the target surface by controlling target rotation such that the electron beam impinges alternatively on the first and second regions. The computing device processes the projection data corresponding to the deflected focal spot positions and reconstructs images of a subject using the processed projection data. | 06-26-2014 |
20140171410 | Batrachotoxin Analogues, Compositions, Uses, and Preparation Thereof - Compounds relating to batrachotoxin are provided, in particular analogues that modulate the activity of sodium channels. Also provided are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier, including vehicles that modulate transdermal permeation of the compound. The subject compounds are useful in treatments, including treatments to reduce neuronal activity or to bring about muscular relaxation. The compounds also find use in the treatment of subjects suffering from a voltage-gated sodium channel-enhanced ailment or from pain. Further methods are provided for the preparation of the batrachotoxin-related compounds. | 06-19-2014 |
20140162960 | Scaffold-Kinase Interaction Blockades and Uses Thereof in Treating Cancer - Aspects of the invention include compositions and methods for inhibiting the interaction between scaffold proteins and kinases. These compositions and methods find a number of uses including, for example, suppressing tumor growth and metastasis and reducing tumor size and number in a mammal with cancer. | 06-12-2014 |
20140161805 | Methods for Manipulating Phagocytosis Mediated by CD47 - Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable. | 06-12-2014 |
20140155329 | Long-Acting Peptide Analogs - Long-acting agonistic analogs for CLR/RAMP receptors are provided that have an extended half-live in vivo. | 06-05-2014 |
20140148880 | Upconversion of Light for Use in Optogenetic Methods - Provided herein are compositions comprising lanthanide-doped nanoparticles which upconvert electromagnetic radiation from infrared or near infrared wavelengths into the visible light spectrum. Also provided herein are methods activating light-responsive opsin proteins expressed on plasma membranes of neurons and selectively altering the membrane polarization state of the neurons using the light delivered by the lanthanide-doped nanoparticles. | 05-29-2014 |
20140148351 | Prediction of Clinical Outcome in Hematological Malignancies Using a Self-Renewal Expression Signature - Methods, compositions, and kits are provided for providing a diagnosis, a prognosis, or a prediction of responsiveness to a therapy for a patient with a hematological malignancy. In practicing the subject methods, the expression level of at least one leukemia stem cell (LSC) genes in a tissue sample is assayed to obtain an LSC expression representation. The LSC expression representation is then employed to determine if an individual has a hematological malignancy, to provide a prognosis to a patient with a hematological malignancy, and/or to provide a prediction of the responsiveness of a patient with a hematological malignancy to a therapy. Also provided are screening methods for identifying novel therapies for patients with a hematological malignancy, and compositions and kits for use in these screening methods. | 05-29-2014 |
20140142437 | SYSTEMS AND METHODS FOR MONITORING HEART FUNCTION - Characteristics of a user's heart are detected. In accordance with an example embodiment, a ballistocardiogram (BCG) sensor is used to detect heart characteristics of a user, and provide a BCG output indicative of the detected heart characteristics. The BCG output is further processed using data from one or more additional sensors, such as to reduce noise and/or otherwise process the BCG signal to characterize the user's heart function. | 05-22-2014 |
20140141449 | Autoantibody Biomarkers for IGA Nephropathy - Aspects of the present invention include methods for diagnosing and monitoring IgAN in a subject. In practicing one aspect of the subject methods, a sample from a subject is analyzed for the presence of one or more specific autoantibodies to determine the IgAN phenotype of the subject. Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods. The methods and compositions find use in a variety of applications. | 05-22-2014 |
20140141061 | Use of WNT Agents to Prevent Hypoxic Injury - Methods and compositions are provided for the therapeutic use of Wnt proteins or Wnt agonists in protecting tissue from the adverse effects of hypoxia. | 05-22-2014 |
20140140930 | NON-PEPTIDIC QUENCHED FLUORESCENT IMAGING PROBES - Methods and materials for the imaging of cells and tissues containing active proteases such as cathepsin are disclosed. The present materials include activity based probes that bind to an enzyme and are subsequently cleaved. Cleavage results in covalent attachment of a fluorescent signal to a target protease due to removal of a quenching group which, when present on the probe causes altered or no fluorescence. The probes are non-peptidic, small molecule scaffolds linked to a reactive acyloxymethyl ketone group, a fluorophore and a quencher. The probes are cell permeable and may use, for example, a QSY21 (CAS 304014-13-9) quencher and a cyanine dye. The probes form covalent bonds with the active site of cysteine cathepsins, proteases that are upregulated at the tumor boundaries with normal tissue and at sites of inflammation. | 05-22-2014 |
20140138612 | FULLERENE-DOPED NANOSTRUCTURES AND METHODS THEREFOR - Nanostructures are doped to set conductivity characteristics. In accordance with various example embodiments, nanostructures such as carbon nanotubes are doped with a halogenated fullerene type of dopant material. In some implementations, the dopant material is deposited from solution or by vapor deposition, and used to dope the nanotubes to increase the thermal and/or electrical conductivity of the nanotubes. | 05-22-2014 |
20140135563 | PLURIDIRECTIONAL VERY HIGH ELECTRON ENERGY RADIATION THERAPY SYSTEMS AND PROCESSES - A compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided, that can deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a better degree of dose conformity or sculpting than conventional photon therapy. In addition to the unique physical advantages of extremely rapid radiation delivery, there may also be radiobiological advantages in terms of greater tumor or other target control efficacy for the same physical radiation dose. | 05-15-2014 |
20140134733 | CHEMICALLY DEFINED PRODUCTION OF CARDIOMYOCYTES FROM PLURIPOTENT STEM CELLS - Methods are provided for producing a cardiomyocyte population from a mammalian pluripotent stem cell population. Aspects of the methods include using a Wnt signaling agonist and antagonist, each in minimal media, to modulate Wnt signaling. Also provided are kits for practicing the methods described herein. | 05-15-2014 |
20140134613 | Direct Molecular Diagnosis of Fetal Aneuploidy - Methods and materials for detection of aneuploidy and other chromosomal abnormalities using fetal tissue are disclosed. Results can be obtained rapidly, without cell culture. The method uses digital PCR for amplification and detection of single target sequences, allowing an accurate count of a specific chromosome or chromosomal region. Specific polynucleic acid primers and probes are disclosed for chromosomes 1, 13, 18, 21, X and Y. These polynucleic acid sequences are chosen to be essentially invariant between individuals, so the test is not dependent on sequence differences between fetus and mother. | 05-15-2014 |
20140134167 | Transforming growth factor-beta (TGF-beta) antagonists for use in treating pain - Provided herein are methods for treating pain and for reducing the excitability of nociceptors, comprising administering a TGF-β antagonist. In some embodiments, a TGF-β antagonist is a monoclonal TGF-f3 neutralizing antibody or a fusion product comprising a monoclonal TGF-β neutralizing antibody, a soluble receptor, an antisense oligodeoxynucleotides (ODNs), a ribozymes, a small inhibitory RNA (siRNA), Smad 6, Smad7, or a small molecule that blocks TGF-β signaling. | 05-15-2014 |
20140134145 | METHOD TO INDUCE AND EXPAND THERAPEUTIC ALLOANTIGEN-SPECIFIC HUMAN REGULATORY T CELLS IN LARGE-SCALE - Methods for inducing, expanding, and/or generating alloantigen-specific regulatory T cells. Alloantigen-specific regulatory T cells can be induced, expanded, and/or generated from naive CD4 | 05-15-2014 |
20140133740 | INTELLIGENT PART IDENTIFICATION FOR USE WITH SCENE CHARACTERIZATION OR MOTION CAPTURE - A variety of methods, systems, devices and arrangements are implemented for use with motion capture. One such method is implemented for identifying salient points from three-dimensional image data. The method involves the execution of instructions on a computer system to generate a three-dimensional surface mesh from the three-dimensional image data. Lengths of possible paths from a plurality of points on the three-dimensional surface mesh to a common reference point are categorized. The categorized lengths of possible paths are used to identify a subset of the plurality of points as salient points. | 05-15-2014 |
20140131769 | SILICON-COMPATIBLE COMPOUND JUNCTIONLESS FIELD EFFECT TRANSISTOR - The present invention provides a silicon-compatible compound junctionless field effect transistor enabled to be compatible to a bulk silicon substrate for substituting an expensive SOI substrate, to form a blocking semiconductor layer between a silicon substrate and an active layer by a semiconductor material having a specific difference of energy bandgap from that of the active layer to substitute a prior buried oxide for blocking a leakage current at an off-operation time and to form the active layer by a semiconductor layer having electron or hole mobility higher than that of silicon, and to operate perfectly as a junctionless device though the dopant concentration of the active layer is much lower than the prior junctionless device. | 05-15-2014 |
20140131023 | STRUCTURES FOR RADIATIVE COOLING - Various aspects as described herein are directed to a radiative cooling device and method for cooling an object. As consistent with one or more embodiments, a radiative cooling device includes a solar spectrum reflecting structure configured and arranged to suppress light modes, and a thermally-emissive structure configured and arranged to facilitate thermally-generated electromagnetic emissions from the object and in mid-infrared (IR) wavelengths. | 05-15-2014 |
20140130597 | GYROSCOPE UTILIZING TORSIONAL SPRINGS AND OPTICAL SENSING - A gyroscope and a method of detecting rotation are provided. The gyroscope includes a structure configured to be driven to move about a drive axis. The structure is further configured to move about a sense axis in response to a Coriolis force generated by rotation of the structure about a rotational axis while moving about the drive axis. The structure further includes at least one first torsional spring extending generally along the drive axis and at least one second torsional spring extending generally along the sense axis. The gyroscope further includes an optical sensor system configured to optically measure movement of the structure about the sense axis. | 05-15-2014 |
20140130214 | MONOLITHIC INTERFEROMETRIC ATOMIC FORCE MICROSCOPY DEVICE - A fiber-facet AFM probe enabling high-resolution, high sensitivity measurement of a sample surface is presented. AFM probes in accordance with the present invention include an optically resonant cavity that is defined by two mirrors, at least one of which is a photonic-crystal mirror. One of the mirrors is movable and is mechanically coupled with an AFM tip such that a force imparted on the tip by an interaction with the sample surface induces a change in the cavity length of the optically resonant cavity and, therefore, its reflectivity. | 05-08-2014 |
20140130213 | INTERFEROMETRIC ATOMIC-FORCE MICROSCOPY DEVICE AND METHOD - A high-bandwidth AFM probe having a diffraction grating characterized by a diffraction characteristic that monotonically changes along the length of the diffraction grating is disclosed. AFM probes in accordance with the present invention are capable of high-sensitivity performance over a broad range of operating conditions, such as operating wavelength and measurement media. A method for estimating at least one physical property of a surface based on high-frequency signal components in the output signal from a high-bandwidth AFM probe is also disclosed. The method enables determination of tip-surface interaction forces based on the relationship between a first motion of the base of the AFM probe and a second motion of the tip of the AFM probe. | 05-08-2014 |
20140126666 | EXPLOITING SPATIAL DEGREES OF FREEDOM IN MULTIPLE INPUT MULTIPLE OUTPUT (MIMO) RADIO SYSTEMS - Methods and apparatuses, including computer program products, are provided for determining the null-space for a channel between a transmitter and an unintended receiver. In one aspect there is provided a method. The method may include transmitting, by a secondary transmitter, a plurality of learning signals, determining, for each of the plurality of learning signals, a value representative of an interference caused by the transmitting to an unintended receiver, determining, based on the determined values, a null-space for a channel between the secondary transmitter and the unintended receiver and transmitting, by the secondary transmitter, a signal in accordance with the determined null-space. | 05-08-2014 |
20140114811 | Method and System for Implementing License Filtering in a Digital Delivery System - In an embodiment, a computer-implemented intellectual property exchange module manages a price rules database along with many items of digital content (e.g. documents). The intellectual property exchange module maintains information (e.g., a unique identifiers) about where the digital documents reside anywhere on the World Wide Web and delivers the documents to a consumer by means of a hyperlink. In an embodiment of the present invention, a document identifier database maintains information about where a document may reside. An embodiment of the present invention implements license filtering so as to dynamically filter for pre-existing applicable licenses. For example, license filtering is used to translate the many details of a legal license into concepts that can be implemented in a digital computer. | 04-24-2014 |
20140114304 | ABLATION CATHETER SYSTEM AND METHOD FOR DEPLOYING SAME - An ablation therapy system is disclosed comprising an ablation catheter system for treating atrial fibrillation (AF). The ablation catheter system comprises a catheter body including a lumen for receiving a visualization catheter, an ablation element for ablating tissue in a patient's heart having abnormal electrical activity, a support assembly for supporting the ablation element, the support assembly being supported by the catheter assembly. The support assembly includes a lumen to receive the visualization catheter, wherein the support assembly is configured to rotate and/or pivot with respect to the catheter body. | 04-24-2014 |
20140113367 | Systems, Methods and Compositions for Optical Stimulation of Target Cells - Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light-activated NpHR-based molecule and a promoter. Either a high expression of the molecule manifests a toxicity level that is less than about 75%, or the light-activated NpHR-based proteins are expressed using at least two NpHR-based molecular variants. Each of the variants characterized in being useful for expressing a light-activated NpHR-based molecule that responds to light by producing an inhibitory current to dissuade depolarization of the neuron. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion pumps or for controlling inhibitory currents in a cell (e.g., in in vivo and in vitro environments). | 04-24-2014 |
20140112882 | Methods to treat pancreatic inflammation and associated lung injury through regulation of pancreatic interleukin-22 expression - Methods for use of a composition comprising agents that increase pancreatic interleukin-22 production in the treatment of pancreatic inflammatory disorders including pancreatitis-associated acute lung injury. | 04-24-2014 |
20140112564 | Comprehensive Cardiovascular Analysis with Volumetric Phase-Contrast MRI - Processing techniques of volumetric anatomic and vector field data from volumetric phase-contrast MRI on a magnetic resonance imaging (MRI) system are provided to evaluate the physiology of the heart and vessels. This method includes the steps of: (1) correcting for phase-error in the source data, (2) visualizing the vector field superimposed on the anatomic data, (3) using this visualization to select and view planes in the volume, and (4) using these planes to delineate the boundaries of the heart and vessels so that measurements of the heart and vessels can be accurately obtained. | 04-24-2014 |
20140106976 | Compressed Sensing for Simultaneous Measurement of Multiple Different Biological Molecule Types in a Sample - A method and apparatus for simultaneously determining multiple different biological molecule types in a sample include labeling each different biological molecule type in a biological sample with a unique combination of a plurality of labels. Each different biological molecule type is selected from a population of M different biological molecules types. The plurality of labels is selected from a population of L different labels; and, M is greater than L. Measurements are obtained of relative abundances of the L different labels in the sample. Relative abundance of up to M different biological molecule types in the sample are determined based on the measurements and a method of compressed sensing. | 04-17-2014 |
20140103297 | ORGANIC MATERIAL-BASED GRAPHITIC MATERIAL - Various methods and apparatuses involve the provision of graphitic material. As consistent with one or more aspects herein, an organic material template is used to restrict growth, in a width dimension, of graphitic material grown from the organic material template. Graphitic material is therein provided, having a set of characteristics including electrical behavior and shape, with a representative width defined by the width dimension, based on the organic material template. | 04-17-2014 |
20140102901 | NEGATIVE DIELECTROPHORESIS FOR SELECTIVE ELUTION OF IMMUMO-BOUND PARTICLES - The procedure of dielectric electrophoresis (dielectrophoresis or DEP) utilizes field-polarized particles that move under the application of positive (attractive) and/or negative (repulsive) applied forces. This invention uses negative dielectric electrophoresis (negative dielectrophoresis or nDEP) within a microchannel separation apparatus to make particles move (detached) or remain stationary (attached). In an embodiment of the present invention, the nDEP force generated was strong enough to detach Ag-Ab (antigen-antibody) bonds, which are in the order of 400 pN (piconewtons) while maintaining the integrity of the system components. | 04-17-2014 |
20140102686 | THERMAL EXTRACTION USING RADIATION - In one embodiment of the present disclosure, a device is disclosed comprising a macroscopic thermal body and an extraction structure that is electromagnetically-coupled to the thermal emitting area of the thermal body. The macroscopic thermal body having a thermal emitting area, and the extraction structure configured and arranged to facilitate emission from, or receipt to the thermal emitting area that exceeds a theoretical, Stefan-Boltzmann, emission limit for a blackbody having the same thermal emitting area as the thermal body. | 04-17-2014 |
20140094380 | Methylation Biomarkers for Diagnosis of Prostate Cancer - Biomarkers for diagnosis and prognosis of prostate cancer are provided. The biomarkers are promoter sequences have altered methylation patterns relative to normal prostate tissue. Altered expression of DNA methyltransferases (DNMT) and proteins that interact with DNMT result in increased methylation at a subset of prostate tumor hypermethylation sites. | 04-03-2014 |
20140090981 | FLOW CONTROL METHOD AND APPARATUSES - Aspects of the present disclosure are directed to the flow of analytes, particles or other materials. As consistent with one or more embodiments described herein, an apparatus includes a membrane having one or more pores in a membrane. First and second electrodes facilitate electrophoretic flow of analytes through the pore, and a third electrode controls movement of the particles in the pore by modulating the shape of an electric double layer adjacent sidewalls of pore. This modulation controls the strength of an electroosmotic field that opposes the electrophoretic flow of the analytes via the pore | 04-03-2014 |
20140090870 | NANOWIRE APPARATUSES AND METHODS - Aspects of the present disclosure are directed to apparatuses and methods involving nanowires having junctions therebetween. As consistent with one or more embodiments, an apparatus includes first and second sets of nanowires, in which the second set overlaps the first set. The apparatus further includes a plurality of nanowire joining recrystallization junctions, each junction including material from a nanowire of the first set that is recrystallized into an overlapping nanowire of the second set. | 04-03-2014 |
20140087376 | METHODS OF DETECTING ANEUPLOIDY IN HUMAN EMBRYOS - Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 03-27-2014 |
20140082758 | Control and Characterization of Psychotic States - Provided herein are methods of inducing psychosis in animals using light-responsive opsins and methods of identifying or screening compounds that may be useful in treating psychosis. | 03-20-2014 |
20140079630 | CARBON NANOTUBES FOR IMAGING AND DRUG DELIVERY - The invention provides compositions and methods for visualizing particular tissues and delivering one or more therapeutics to that tissue using single-walled carbon nanotubes (SWNTs), which are taken up and delivered to target tissues by specific monocytes in the body. The delivery of SWNT to target tissues allows the visualization of the affected tissue for diagnostics and therapy in diseases where the specific monocyte is implicated in the disease pathogenesis. These nanotubes can be conjugated to a peptide, such as RGD, which helps direct the SWNT-containing monocytes to the vascular endothelium. | 03-20-2014 |
20140073531 | NANO-SENSOR ARRAY - In one embodiment, a method is provided for the manufacture of a nano-sensor array. A base having a sensing region is provided along with a plurality of nano-sensors. Each of the plurality of nano-sensors is formed by: forming a first nanoneedle along a surface of the base, forming a dielectric on the first nanoneedle, and forming a second nanoneedle on the dielectric layer. The first nanoneedle of each sensor has a first end adjacent to the sensing region of the base. The second nanoneedle is separated from the first nanoneedle by the dielectric and has a first end adjacent the first end of the first nanoneedle. The base is provided with a fluidic channel. The plurality of nano-sensors and the fluidic channel are configured and arranged with the first ends proximate the fluidic channel to facilitate sensing of targeted matter in the fluidic channel. | 03-13-2014 |
20140073525 | DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC USES OF LONG NON-CODING RNAS FOR CANCER AND REGENERATIVE MEDICINE - Long non-coding RNAs (lncRNAs) and methods of using them diagnostically and therapeutically for treatment of cancer, stem cell therapy, or regenerative medicine are disclosed. In particular, the invention relates to lncRNAs that that play roles in regulation of genes involved in cell proliferation, differentiation, and apoptosis. Such lncRNAs can be used as biomarkers to monitor cell proliferation and differentiation during cancer progression or tissue regeneration. One of the identified lncRNAs, referred to as PANDA (a P21-Associated NcRNA, DNA damage Activated), inhibits the expression of apoptotic genes normally activated by the transcription factor NF-YA. Inhibitors of PANDA sensitize cancerous cells to chemotherapy and can be used in combination with chemotherapeutic agents for treatment of cancer. | 03-13-2014 |
20140073518 | FUSION PROTEINS COMPRISING AN ENGINEERED KNOTTIN PEPTIDE AND USES THEREOF - The present disclosure presents a general approach to engineering existing protein-protein interactions through domain addition and evolution. The disclosure teaches the creation of novel fusion proteins that include knottin peptides where a portion of the knottin peptide is replaced with a sequence that has been created for binding to a particular target. Such fusion proteins can also be bispecific or multi specific in that they can bind to and/or inhibit two or more receptors or receptor ligands. Knottins may be fused with an existing ligand (or receptor) as a general platform for increasing the affinity of a ligand-receptor interaction or for creating a multi specific protein. In addition, the fusion proteins may comprise a knottin peptide fused to another protein where the other protein facilitates proper expression and folding of the knottin. | 03-13-2014 |
20140065143 | Inhibition of AXL Signaling in Anti-Metastatic Therapy - Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL and its ligand GAS6. | 03-06-2014 |
20140064654 | MULTIMODE FIBER FOR SPATIAL SCANNING - A method for imaging a scan region by controlling at least one of the relative phase and relative amplitude of multiple optical modes propagating through a multimode optical fiber to control the position of an output beam emitted from the output facet of the optical fiber is disclosed. | 03-06-2014 |
20140062255 | PIEZOELECTRIC APPARATUSES, SYSTEMS AND METHODS THEREFOR - Various aspects as described herein are directed to piezoelectric materials. As consistent with one or more embodiments, an apparatus includes a nanomaterial and structures coupled to the nanomaterial. This nanomaterial-structure combination manifests piezoelectric characteristics, via the combination. In certain implementations, neither the nanomaterial nor the coupled structures independently exhibit piezoelectric characteristics, yet do so in combination. | 03-06-2014 |
20140058217 | MOTION ARTIFACT MITIGATION METHODS AND DEVICES FOR PULSE PHOTOPLETHYSMOGRAPHY - Aspects of the present disclosure are directed toward devices, apparatus, and methods for interfacing a PPG apparatus with the skin surface of a patient and sensing artifacts due to surface motion attributable to contact-based surface motion at or near where the apparatus in contact with the skin surface of the patient. The devices, apparatus, and methods include circuitry that contacts the skin surface of the patient, illuminates tissue at the surface, and senses a pulse photoplethysmography (PPG) signal of the patient in response thereto. Further, the circuitry senses artifacts due to surface motion, and responds to the sensed PPG signal by processing the sensed PPG signal relative to the sensed artifacts to produce a version of the sensed PPG signal that is indicative local blood volume and composition of the patient, and filtered to suppress noise therein due to the contact-based surface motion. | 02-27-2014 |
20140058065 | FAR-RED FLUORESCENT PROTEINS WITH IMPROVED DETECTABILITY BY RED EXCITATION LIGHT - Aspects of the present disclosure are directed towards far-red monomeric fluorescent proteins that have a high level of brightness such that the proteins are visible over the autofluorescence aspects of tissue. In certain embodiments, the fluorescent proteins are derived from | 02-27-2014 |
20140057247 | METHOD OF PREPARING RNA FROM RIBONUCLEASE-RICH SOURCES - Methods for preparing RNA from ribonuclease-rich sources while avoiding RNA degradation are described. The lysis protocol for ribonuclease-containing samples is performed at high pH to accelerate cell lysis and with a reducing agent that inactivates ribonucleases (RNases) by reducing disulfide bonds essential for RNase activity. Samples are briefly incubated for up to five minutes at high pH followed by addition of a reagent to lower the pH to a level at which the RNA is stable. This method of RNA extraction has many advantages over existing methods of RNA preparation, including that cell lysis is efficient, RNases are rapidly inactivated, and sample incubation times are short (less than 5 minutes), which protects RNA from degradation. The lysing procedure is performed entirely in aqueous solution with no heating, precipitations, or buffer exchanges required. Thus, a quick, simple procedure for extracting RNA is provided, which can easily be automated. | 02-27-2014 |
20140056929 | IMMUNOMODULATION BY CONTROLLING INTERFERON-GAMMA LEVELS WITH THE LONG NON-CODING RNA NeST - Compositions and methods of modulating an immune response by controlling levels of interferon-gamma (IFN-γ) production by leukocytes are disclosed. Adjustment of IFN-γ levels is achieved by increasing or decreasing the activity of NeST (nettoie | 02-27-2014 |
20140050781 | Use of AGR3 for Treating Cancer - Embodiments are related to processes for using an Anterior Gradient Homolog 3 (AGR3) therapeutic to treat an enhanced AGR2 expressing cancer, or its premalignant precursor, comprising administering an amount of an AGR3 therapeutic to a human patient in need thereof. | 02-20-2014 |
20140049663 | IMAGING ARRANGEMENTS AND METHODS THEREFOR - Image data is processed to facilitate focusing and/or optical correction. According to an example embodiment of the present invention, an imaging arrangement collects light data corresponding to light passing through a particular focal plane. The light data is collected using an approach that facilitates the determination of the direction from which various portions of the light incident upon a portion of the focal plane emanate from. Using this directional information in connection with value of the light as detected by photosensors, an image represented by the light is selectively focused and/or corrected. | 02-20-2014 |
20140045705 | Techniques for Determining Haplotype by Population Genotype and Sequence Data - A novel phasing algorithm harnesses sequencing read information from next generation sequencing technologies to guide and improve local haplotype reconstruction from genotypes. Techniques include determining correlated occurrences of single nucleotide polymorphisms (SNPs) in genes of a population of individuals. A plurality of sequences of nucleotide bases in one or more individuals from the populations of individuals is determined based on ultra-high throughput sequencing of a sample from the one or more individuals. Haplotypes included in the population of individuals are determined based on both the correlated occurrences and the plurality of sequences. The inclusion of paired end read data is especially advantageous for the phasing of rare variants, including singletons. | 02-13-2014 |
20140044144 | Vertical Cavity Surface Emitting Laser Nanoscope for Near-field Applications - A vertical cavity surface emitting laser (VCSEL) nanoscope is provided. The VCSEL nanoscope combines a VCSEL with a nano-scale aperture using a support member to separate the aperture from the VCSEL emission face. The resulting device is a useful near-field probe with a wide variety of applications. | 02-13-2014 |
20140028892 | IMAGING ARRANGEMENTS AND METHODS THEREFOR - Image data is processed to facilitate focusing and/or optical correction. According to an example embodiment of the present invention, an imaging arrangement collects light data corresponding to light passing through a particular focal plane. The light data is collected using an approach that facilitates the determination of the direction from which various portions of the light incident upon a portion of the focal plane emanate from. Using this directional information in connection with value of the light as detected by photosensors, an image represented by the light is selectively focused and/or corrected. | 01-30-2014 |
20140024701 | Compositions and Methods for Treating Neurogenic Disorders of the Pelvic Floor - Provided herein are methods for the treatment of bladder dysfunction, including detrusor hyperreflexia and detrusor external sphincter dyssynergia, fecal incontinence, and/or sexual dysfunction in an individual via the use of stably expressed light-responsive opsin proteins capable of selective hyperpolarization or depolarization of the neural cells that innervate the muscles responsible for physiologic functioning of urinary bladder, external urinary sphincter, external anal sphincter, and the male and female genitalia. | 01-23-2014 |
20140024649 | Substituted Benzamides and Their Uses - Provided herein are Substituted Benzamides, compositions, and method of their manufacture and use. | 01-23-2014 |
20140021907 | Wireless energy transfer - Electromagnetic energy transfer is facilitated. In accordance with an example embodiment, a first resonator transmits electromagnetic energy using an electromagnetic wave, based on frequency matching and alignment of an electromagnetic field with a second resonator within one wavelength of the electromagnetic wave distance from the first resonator. An electromagnetic energy reflector adjacent the first resonator redirects reflected portions of the electromagnetic wave back towards the first resonator circuit. | 01-23-2014 |
20140017322 | SUPRAMOLECULAR FUNCTIONALIZATION OF GRAPHITIC NANOPARTICLES FOR DRUG DELIVERY - Disclosed are nanoparticles, such as carbon nanotubes or other graphitic sheet materials having extended aromatic surfaces, which are used to deliver active agents such as drugs, labels or dyes (termed for convenience a “drug”) to the interior of cells. The nanoparticles are functionalized by a hydrophilic polymer or adsorption of an amphiphilic molecule to render them stable in suspension. The drug is therefore capable of release in the cell exterior. The drug is more rapidly released at lower pH, as found e.g., in tumor cells. The drug may also be linked to a branched chain hydrophilic polymer, so that each polymer molecule carries more than one drug bound by a cleavable linker. | 01-16-2014 |
20140014515 | Enhanced Isotachophoresis Assays Using Additives with Spatial Gradients - Techniques for enhanced isotachophoresis assays using additives with spatial gradients include forming a concentration gradient of an additive along a channel from an input port to an output port. The channel is used for isotachophoresis with ions of a leading electrolyte having a first mobility greater than a mobility of an analyte, and ions of a trailing electrolyte having a second mobility less than the mobility of the analyte. The additive is different from both the leading electrolyte and the trailing electrolyte; and the additive has a third mobility that assures the analyte will encounter the additive. The method further comprises introducing a mixture of the trailing electrolyte and a sample including the analyte. The method further comprises applying an electric field to the channel; and, measuring the analyte. | 01-16-2014 |
20140010791 | METHODS FOR REGULATING PROTEIN FUNCTION IN CELLS IN VIVO USING SYNTHETIC SMALL MOLECULES - Methods and compositions for the rapid and reversible destabilizing of specific proteins in vivo using cell-permeable, synthetic molecules are described. | 01-09-2014 |
20140010757 | IMAGING METHODS USING ENGINEERED INTEGRIN BINDING PEPTIDES - Engineered peptides that bind with high affinity (low equilibrium dissociation constant (Kd)) to the cell surface receptors of fibronectin (α | 01-09-2014 |
20140004556 | Methods for Generating Inner Ear Cells in Vitro | 01-02-2014 |
20140001437 | JOINED NANOSTRUCTURES AND METHODS THEREFOR | 01-02-2014 |
20140000622 | DEVICES AND METHODS FOR PREVENTING TRACHEAL ASPIRATION | 01-02-2014 |
20130347137 | Stabilized Step Function Opsin Proteins and Methods of Using the Same - Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to selectively depolarize neurons residing in microcircuits of the pre-frontal cortex to affect one or more social behaviors, communications, and/or conditioned behaviors in the non-human animal. | 12-26-2013 |
20130345232 | METHODS AND COMPOSITIONS FOR TREATING A SUBJECT FOR A LYMPHATIC MALFORMATION - Methods of treating lymphatic malformations using a phosphodiesterase type 5 inhibitor are provided. Pharmaceutical compositions and kits comprising phosphodiesterase type 5 inhibitors are also provided. | 12-26-2013 |
20130343998 | Control and Characterization of Memory Function - Provided herein are devices and methods for reversibly controlling memory function in living non-human animals. Some variations of methods for affecting memory function comprise temporarily inhibiting neurons of the hippocampus (e.g., neurons of the dorsal CA1 field of the hippocampus) during the acquisition or retrieval of a memory. Alternatively or additionally, methods for reversibly affecting memory function comprise inhibiting neurons of the amygdala (e.g. basolateral amygdala) and/or neurons of the cingulate cortex (e.g., anterior cingulated cortex). Methods for disrupting the formation and recall of memories by inhibiting excitatory neurons expressing light-activated proteins are disclosed herein. One or more methods for reversibly affecting memory function described herein can be used to evaluate the effectiveness of pharmacological agents in treating PTSD and/or various memory disorders. | 12-26-2013 |
20130340232 | METHOD OF FABRICATING AN OPTICAL-FIBER-COMPATIBLE SENSOR - A method for fabricating a sensor is provided, with the sensor including a reflective element and an optical fiber positioned relative to the reflective element such that light emitted from the optical fiber is reflected by the reflective element and propagates in an optical cavity between the optical fiber and the reflective element. The method includes positioning an element within the optical cavity. The element has a coefficient of thermal expansion and a thickness that compensate a refractive index change with temperature of a medium within the optical cavity. | 12-26-2013 |
20130332315 | METHOD AND RELATED APPARATUS FOR GENERATING ONLINE AND PRINTING ON-DEMAND COMPILATION OF WORKS WITH CUSTOMER SELECTABLE PRINTING OPTIONS - A method and related computer program product for customizing price-related options for printing a compilation of works, including the steps of: compiling the compilation of works; setting different options for customers to print the compilation of works with different prices; and allowing a customer to change one or more of the options to print the compilation of works with a price based on the customer's needs and budget. | 12-12-2013 |
20130331646 | APPARATUS, SYSTEMS, AND METHODS FOR PERFORMING LAPAROSCOPIC SURGERY - Apparatus, systems, and methods for laparoscopic abdominal surgery are disclosed. For example, a system or kit is provided for performing a procedure within a surgical space within a patient's body that includes a plurality of tool heads, and a tool head carrier including features for removably receiving one or more tool heads, the tool head carrier sized for introduction through a trocar or other port into a surgical space. The system or kit may also include a surgical tool including a tool shaft introduceable into the surgical space and including features for securing a tool head to the tool. Optionally, the tool head carrier may include a clip for securing the tool head carrier to an endoscope. | 12-12-2013 |
20130331441 | Cell Line, System and Method for Optical Control of Secondary Messengers - A variety of methods, devices and compositions are implemented for light-activated molecules. One such method is implemented for generating secondary messengers in a cell. A nucleotide sequence for expressing a chimeric light responsive membrane protein (e.g., rhodopsin) is modified with one or more heterologous receptor subunits {e.g., an adrenergic receptor (alpha1, Beta2)}. The light responsive membrane protein is expressed in a cell for producing a secondary messenger in response to light. | 12-12-2013 |
20130330816 | Apparatus and Methods for Controlling Cellular Development - According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate the light source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells. | 12-12-2013 |
20130330294 | Serum Amyloid A (SAA) Overrides Regulatory T Cells (TREG) Anergy - Methods and compositions are provided for inducing the proliferation of regulatory T cells. These methods find a number of uses, including, for example, treating autoimmune and rheumatoid diseases. Also provided are reagents and kits that find use in these methods. | 12-12-2013 |
20130328684 | SYSTEM AND METHOD FOR DETECTING AND PREVENTING DROWSINESS - A system for preventing drowsiness in a driver by employing a thermal grill. The system includes a detection module and an intervention module. The detection module monitors a driver's parameters to determine whether the driver is drowsy. If the driver is determined to be drowsy, the intervention module activates a thermal grill with interlaced hot and cold regions. This activation causes the hot regions to approach one temperature and the cold regions to approach another. Additionally, this activation leads to an uncomfortable sensation for the driver, alerts the driver, and prevents the driver from getting drowsy. | 12-12-2013 |
20130324707 | SYNTHETIC AMPHIPHILES FOR MEMBRANE PROTEIN MANIPULATION - The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas I-XIX, can be prepared from readily available starting materials. The amphiphilic compounds can manipulate membrane protein at relatively low concentrations compared to many known detergents. The compounds can be used to aid the isolation of membrane proteins, for example, to aid their solubilization and/or purification. The compounds can also be used to aid the functional and structural determination of membrane proteins, including their stabilization and crystallization. | 12-05-2013 |
20130317575 | Implantable Optical Stimulators - Various systems and methods are implemented for in vivo use in a living animal. One such method involves stimulating target cells having light-responsive proteins and includes providing an elongated light-delivery structure in a narrow passageway in the animal, the elongated light-delivery structure having separately-activatable light sources located along the length of the elongated light-delivery structure. The method also includes activating less than all the light sources to deliver light to light-responsive proteins adjacent to the activated light sources along the length of the elongated light-delivery structure, thereby stimulating target cells in vivo. | 11-28-2013 |
20130317569 | Optogenetic Control of Reward-Related Behaviors - Provided herein are compositions and methods for disrupting at least one reward-related behavior in an individual through the use of light-responsive opsin proteins used to control the polarization state of the cholinergic interneurons of the nucleus accumbens or the striatum. | 11-28-2013 |