| The Board of Regents of the University of Texas System Patent applications |
| Patent application number | Title | Published |
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| 20120135408 | UNC-45A SPLICE VARIANTS BASED CANCER DIAGNOSTICS AND THERAPEUTICS - Methods and compositions to diagnose and treat cancers using UNC-45A splice variants are disclosed. Expression of a human UNC-45A929 splice variant that is shorter than UNC-45A944 splice variant is increased in cancer cells including metastatic cancers. siRNA to inhibit or downregulate UNC-45A splice variants in cancers are disclosed. | 05-31-2012 |
| 20120115746 | COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING IRRITABLE BOWEL SYNDROME - Compositions and methods for diagnosing and treating CVH and CVH-associated disorders are disclosed. Genes differentially expressed in CVH tissues relative to normal tissues are identified. The genes and the gene products (i.e., the polynucleotides transcribed from and polypeptides encoded by the genes) can be used as markers of CVH. The genes and the gene products can also be used to screen agents that modulate the gene expression or the activities of the gene products. | 05-10-2012 |
| 20120114636 | LOW MOLECULAR WEIGHT CYCLIN E (LMW-E) AS A BIOMARKER FOR PERSONALIZATION OF CANCER THERAPIES - Methods are disclosed for predicting a patient response to anti-Her2 therapy or anti-aromatase therapy. In certain embodiments, the methods involve the identification of low molecular weight cyclin E (LMW-E) in cancers, such as breast cancer cells, as a predictive and prognostic marker. In further embodiments, LMW-E expression by a cancerous or pre-cancerous cell may be used to predict response to an aromatase inhibitor and/or CDK2 inhibitor, and determination of LMW-E expression may be used in the personalization of cancer therapies. | 05-10-2012 |
| 20120114079 | RADIO ARCHITECTURE FOR AN ULTRA LOW POWER RECEIVER - An ultra low power radio receiver architecture based on phase locked loop is provided. Embodiments of an ultra low power radio receiver architecture based on phase locked loop can detect a complex modulated MSK signal with only a single path receiver chain. According to an embodiment of the present invention, the overall power consumption of the radio receiver in the present invention can be reduced by almost fifty percent compared to that of the conventional complex path radio receiver architecture. The radio receiver architecture of the invention is suitable for the ultra low power radio application such as wireless sensor networks (WSN). | 05-10-2012 |
| 20120100181 | Attenuation of Encephalitogenic Alphavirus and Uses Thereof - The present invention is drawn to generating attenuated and less cytopathic forms of New World alphaviruses that can be used in immunogenic compositions as vaccines against both Old and New World alphaviruses. In this regard, the present invention discloses that the N-terminal, ˜35-aa-long peptide of VEEV, EEEV and, most likely, of WEEV capsid proteins plays the most critical role in the downregulation of cellular transcription and development of cytopathic effect. The identified, VEEV-specific peptide, C | 04-26-2012 |
| 20120095443 | NANOCHANNELED DEVICE AND RELATED METHODS - A capsule configured for in vivo refilling of a thereapeutic agent. In certain embodiments, the capsule may contain methotrexate. | 04-19-2012 |
| 20120089794 | METHODS AND DEVICES FOR DETERMINING QUALITY OF SERVICES OF STORAGE SYSTEMS - Methods and systems for allowing access to computer storage systems. Multiple requests from multiple applications can be received and processed efficiently to allow traffic from multiple customers to access the storage system concurrently. | 04-12-2012 |
| 20120070846 | METHODS FOR DETECTING MOLECULE-MOLECULE INTERACTIONS WITH A SINGLE DETECTION CHANNEL - A single molecule or molecule complex detection method is disclosed in certain aspects, comprising nano- or micro-fluidic channels. | 03-22-2012 |
| 20120065521 | NEEDLE BIOBSY IMAGING METHOD - Imaging techniques. Radiation is directed from a source onto a sample using an endoscope having cellular or subcellular resolution. The endoscope includes one or more fibers. The fibers have a proximate end and a distal end, and the distal end is lensless. A focal plane of the endoscope is substantially at a tip of the distal end. Radiation from the sample is directed onto a detector to diagnose or monitor the sample. | 03-15-2012 |
| 20120065495 | NEEDLE BIOBSY IMAGING SYSTEM - Imaging techniques. Radiation is directed from a source onto a sample using an endoscope having cellular or subcellular resolution. The endoscope includes one or more fibers. The fibers have a proximate end and a distal end, and the distal end is lensless. A focal plane of the endoscope is substantially at a tip of the distal end. Radiation from the sample is directed onto a detector to diagnose or monitor the sample. | 03-15-2012 |
| 20120064372 | METHOD FOR IMPARTING ANTIMICROBIAL ACTIVITY TO A MEDICAL DEVICE - A method for imparting broad spectrum antimicrobial activity to a medical device. The medical device is sequentially contacted with a first antimicrobial component, such as an antiseptic, and thereafter with a second antimicrobial component, such as a mixture of antibiotics. The first component may be a guanidium compound, such as chlorhexidine. The second component may be a mixture of a tetracycline, such as minocycline, and a rifamycin, such as rifampin. | 03-15-2012 |
| 20120064143 | INHIBITION OF MAMMALIAN TARGET OF RAPAMYCIN - Disclosed are microcapsules that include an inhibitor of the mammalian target of rapamycin (mTOR) within the microcapsules, and pharmaceutical compositions and kits that include the microcapsules. Also disclosed are methods for treating or preventing an age-related disease, condition, or disorder in a subject that involve administering to a subject a pharmaceutically effective amount of microcapsules that includes an inhibitor of mTOR within the microcapsules. | 03-15-2012 |
| 20120043501 | Polyamine/Alkali Salt Blends for Carbon Dioxide Removal From Gas Streams - Novel solvents and methods of use for the removal of CO | 02-23-2012 |
| 20120014424 | COMMUNICATING CHANNEL STATE INFORMATION USING PREDICTIVE VECTOR QUANTIZATION - Techniques are generally described here for communicating channel state information using predictive vector quantization. In some examples, a method may include measuring channel state information based, at least in part, on signals received over a communications channel. An error vector may be calculated between the measured channel state information and predicted channel state information. The error vector may be quantized, and subsequent channel state information may be predicted based, at least in part, on the quantized error vector. | 01-19-2012 |
| 20120005028 | AD AUCTION OPTIMIZATION - The present disclosure generally relates to ad auction optimization. In some examples, methods, systems, and computer programs for ad auction optimization using machine learning algorithms to estimate a likelihood that a consumer will purchase an advertised product and balance long term and short term goals to determine modeled data for a keyword in an auction are described. | 01-05-2012 |
| 20110319759 | OPTICALLY GUIDED NEEDLE BIOPSY SYSTEM USING MULTI-MODAL SPECTROSCOPY - The present invention includes an apparatus, system and method for detection of tissues, e.g., a cancer, by optical biopsy comprising: a motorized computer-controlled probe holder; a needle-like probe connected to and controlled by the motorized computer-controlled probe holder, the probe comprising an optical and an ultrasound detector; and one or more detector units capable of a broadband light reflectance spectroscopy, an auto fluorescence lifetime measurement, and auto fluorescence spectroscopy measurement. | 12-29-2011 |
| 20110319338 | PEPTIDES THAT BIND EUKARYOTIC TRANSLATION INITIATION FACTOR 4E - Methods, compositions and kits for treating proliferative and non-proliferative diseases associated with abnormal protein synthesis. Chimeric peptide constructs are comprised in compositions and kits for use in the treatment of proliferative diseases, such as ovarian cancer, and for inhibiting protein synthesis in a tumor cell compared to a non-tumor cell. | 12-29-2011 |
| 20110318313 | Modulation of Splenocytes in Cell Therapy for Traumatic Brain Injury - The invention provides methods for treating traumatic brain injury. The invention is generally directed to treating traumatic brain injury by administering cells that have one or more of the following effects in an injured subject: interact with splenocytes, preserve splenic mass, increase proliferation of CD4 | 12-29-2011 |
| 20110313538 | BI-LAYERED BONE-LIKE SCAFFOLDS - Disclosed are biomedical scaffolds that may be used, for example, for treatment of bone diseases and bone repair. Methods of preparing such scaffolds are also disclosed. These scaffolds permit nutrient and ion flow such that bone regeneration in the area surrounding the scaffold is promoted. Also disclosed are kits that include the scaffolds set forth herein. | 12-22-2011 |
| 20110313415 | Medical Devices, Apparatuses, Systems, and Methods - Apparatuses and systems for enabling electrical communication with a device positionable within a body cavity of a patient. Apparatuses and systems for magnetically positioning a device within a body cavity of a patient. Medical devices. Methods of use. | 12-22-2011 |
| 20110311558 | Recombinant Bone Marrow Stromal Antigen-2 in the Treatment of Autoimmune Diseases - Methods, compositions and kits are disclosed for inhibiting interferon production and modulating immune responses, particularly an autoimmune response. In certain embodiments, the methods involve administering an effective amount of a BST2 protein or a nucleic acid encoding an BST2 protein to treat an autoimmune disease or disorder. | 12-22-2011 |
| 20110306948 | METHODS AND COMPOSITIONS RELATED TO TH-1 DENDRITIC CELLS - Certain embodiments of the invention are directed to methods for inducing an immunologic response to a tumor in a patient using mature dendritic cells transfected with a nucleic acid composition encoding one or more tumor antigens and loaded with a corresponding tumor antigen composition. | 12-15-2011 |
| 20110306699 | IN SITU FORMATION OF NANOPARTICLES IN RESINS - Methods of forming antimicrobial polymeric materials comprising metallic nanoparticles are disclosed. Such methods generally comprise: combining a metal-containing material with a resin in situ; and curing the resin in the presence of a metal-containing material. Antimicrobial polymeric materials formed by said methods are also disclosed. | 12-15-2011 |
| 20110269843 | METHODS FOR DELIVERING VOLATILE ANESTHETICS FOR REGIONAL ANESTHESIA AND/OR PAIN RELIEF - The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic such as a halogenated ether compound in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered to the subject to anesthetize the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, xenon, and mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated. | 11-03-2011 |
| 20110268653 | Compositions and Methods Related to Acid Stable Lipid Nanospheres - The present invention relates generally to the fields of chemistry and biochemistry. More particularly, it concerns methods and compositions for the use of fatty asparagine, fatty cysteine, and fatty serine derivatives. | 11-03-2011 |
| 20110237688 | METHODS AND COMPOSITIONS RELATED TO ACETYLOCHOLINE RECEPTOR CONJUGATES - Disclosed are methods, compositions, and diagnostic kits for detecting acetylcholine receptor (AchR) autoreactive immune cells in a subject. The methods comprise detecting the binding of AChR-conjugate to penpheral blood AChR-specific B cells for diagnosing autoimmune disorders, including Myasthenia gravis (MG), systemic lupus erythematous (SLE), and rheumatoid arthritis (RA). More specifically, the detection is achieved by using flow cytometric assay with Alexa-conjugated AchR. | 09-29-2011 |
| 20110236994 | MEASURING CIRCULATING THERAPEUTIC ANTIBODY, ANTIGEN AND ANTIGEN/ANTIBODY COMPLEXES USING ELISA ASSAYS - The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease. | 09-29-2011 |
| 20110229806 | PHASE MASK AND METHOD OF FABRICATION - A method of fabricating a two-layer phase mask comprises subjecting a photoresist material to two overlapping laser beams that create light and dark fringes in the overlapping beam regions. The photoresist can comprise a liquid crystal and a photo-sensitive material, including, for example, a photo-sensitive monomer and/or polymer. The two laser beams can be first directed towards one side of the photoresist. In the areas subjected to lighter fringes, the polymer molecules can link together and force the liquid crystal into the areas subjected to the darker fringes. This can leave an alternating pattern of linear strips of polymer-rich and liquid crystal-rich regions. The exposure time can be limited so that the strips are formed only partially through the thickness of the photoresist. The photoresist can be then rotated 90 degrees and the overlapping laser beams directed towards the opposite side of the photoresist. Alternating strips of polymer-rich and liquid crystal-rich regions can be formed that extend partially through the photoresist. These strips can be arranged orthogonally to the strips formed on the opposite side of the photoresist. The material in liquid crystal-rich regions can be washed out when the photoresist is developed. A two-layer, integrated phase mask can therefore be produced. Exemplary methods eliminate the need for complicated alignment techniques. | 09-22-2011 |
| 20110229435 | EXPRESSION AND PURIFICATION OF HIP/PAP AND USES THEREFOR - The present invention relates to methods of compositions comprising RegIII and HIP/PAP proteins, including the use of such proteins as diagnostic and therapeutic targets. | 09-22-2011 |
| 20110206644 | METHODS FOR TRANS-DIFFERENTIATING CELLS - The present provides methods for affecting and/or altering the differentiation state of a cell. In certain embodiments, the present invention provides methods to transdifferentiate a cell into an endothelial cell or a hematopoietic cell. In the practice of the invention, a demethylating agent (e.g., 5-azacytidine) is used to affect and/or alter the differentiation state of a cell. The invention demonstrates the transdifferentiation of numerous cell types, including cell populations that are themselves somewhat differentiated (e.g., normal fibroblasts) into distinct cell types, including hematopoietic cells and endothelial cells, which transdifferentiation is effected further through the selection of particular growth factors which, together with the demethylating agents, directs the differentiation path. The invention provides a novel approach to providing useful cell types for many types of medical applications. | 08-25-2011 |
| 20110201692 | ANTIMICROBIAL FLUSH SOLUTIONS - The present invention provides antimicrobial solutions that comprise at least one alcohol, at least one antimicrobial agent and at least one chelator and/or anticoagulant. Also provided are methods for rapidly reducing a microbe or a virus from surfaces including surfaces of indwelling medical devices and organic surfaces such as skin and sutures, and inorganic surfaces such as hospital equipment, pipelines etc. | 08-18-2011 |
| 20110200576 | ENGINEERED ENZYMES WITH METHIONINE-GAMMA-LYASE ENZYMES AND PHARMACOLOGICAL PREPARATIONS THEREOF - Methods and composition related to the engineering of a novel protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids. | 08-18-2011 |
| 20110196304 | Fluid Balance Monitoring System with Fluid Infusion Pump for Medical Treatment - Novel fluid delivery systems are disclosed to improve the delivery of bio-compatible fluids to a patient. The systems can include a housing having a bladder pressurized by a pressurization unit so that fluid flow rate can be controlled, changed and/or monitored. The systems can also include a scale and/or a flow control unit. | 08-11-2011 |
| 20110189095 | CRKL TARGETING PEPTIDES - Provided are methods and compositions for selectively targeting CRKL through the use of targeting peptides. Selective targeting of secreted CRKL through the use of a targeting peptide may be used, for example, in the treatment of cancer to deliver a chemotherapeutic compound, fusion protein, or fusion construct to a cancer cell or tissue. | 08-04-2011 |
| 20110172234 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS - This invention describes a series of methods and compositions for prevention and treatment of diseases such as cancer. One aspect of the invention describes small molecule-based drugs that can be used to bind to death receptors TRAIL-R1/DR4 and/or TRAIL-R2/DR5 and induce apoptosis in cancer cells, while sparing normal cells. The invention also describes TRAIL Death Receptor Agonists/Activators (DRAs) and their uses, such as the induction of apoptosis through caspase-8 and caspase-3 activation. The present invention also describes the methods of treating cancers, such as breast, prostate, colon, pancreatic, ovarian, lung, and brain cancers, leukemia, lymphoma, multiple myeloma, and mesothelioma, using DRAs either as single-agent treatments, or in combination with other therapies. | 07-14-2011 |
| 20110171196 | METHODS OF TREATMENT AND USES FOR CAMKII AND ITS INTERACTION WITH HDACS AND CALPAIN - The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension. | 07-14-2011 |
| 20110171072 | Apparatus, System and Method for Label-Free Quantitative Detection of Biomolecules - Embodiments of apparatuses, systems, and methods for label-free detection of biomolecules. In one embodiment, a system includes a light source configured to emit broadband Gaussian light. The system may also include an optical fiber coupled to the light source. Additionally, the system may include an optical sensor. The optical sensor may include a fiber-interface surface configured to be coupled to the optical fiber and to receive broadband Gaussian light from the optical fiber. The optical sensor may also include a sensor body coupled to the fiber-interface surface, the sensor body having a refractive index different from a refractive index of the optical fiber, such that at least a portion of light received by the fiber-interface surface is reflected back to the optical fiber during use; and a binder-interface surface coupled to the sensor body, the binder-interface surface configurable to receive a chemical binder layer. Additional embodiments include coherence domain multiplexing and time division multiplexing. | 07-14-2011 |
| 20110160788 | POSITIVE DISPLACEMENT PUMP SYSTEM AND METHOD - Systems and methods including a motor or electromagnets to control the movement of one or more pistons in a pumping chamber. The pumping chamber may include a pump inlet and a pump outlet in fluid communication with the pumping chamber. Surfaces on a piston or pumping chamber may include hydrodynamic bearing surfaces. | 06-30-2011 |
| 20110144066 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME - Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein. | 06-16-2011 |
| 20110137596 | QUALITY CONTROL METHOD AND MICRO/NANO-CHANNELED DEVICES - Embodiments of the present invention comprise a quality control system and method for testing micro- or nano-channeled devices. The system and method can utilize a pressure-driven gas flow for the detection and quantification of structural defects. The test method and system are non-destructive and allow defects to be detected and classified quickly based on measured factors, such as mass flow rate for a given pressure differential. | 06-09-2011 |
| 20110110860 | MODULATION OF LDL RECEPTOR GENE EXPRESSION WITH DOUBLE-STRANDED RNAS TARGETING THE LDL RECEPTOR GENE PROMOTER - Gene expression can be selectively regulated by double-stranded “antigene” RNAs that target regions of the low density lipoprotein receptor (LDL-R) promoter, thereby permitting modulation of LDL levels in vivo and subsequent effects on circulating LDL levels. | 05-12-2011 |
| 20110092384 | COMPOSITIONS AND METHODS FOR PRODUCING CODED PEPTOID LIBRARIES - Embodiments of the invention are directed to a one-bead-two-compound method for the creation of encoded cyclic peptoid libraries. This scheme is useful for the creation of cyclic peptoid microarrays since only the cyclic peptoid, not the linear encoding molecule, contains an attachment residue and thus can be spotted onto an activated substrate. | 04-21-2011 |
| 20110071118 | Methods of Making Compositions Comprising Lecithin Oils and NSAIDS for Protecting the Gastointestinal Tract and Providing Enhanced Therapeuitc Activity - A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a NSAID-containing formulation that possess low gastrointestinal (GI) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulstion for internal, oral, direct or topical administration. | 03-24-2011 |
| 20110065677 | Methods of Treating Inflammation with Compositions Comprising Lecithin Oils and NSAIDS for Protecting the Gastrointestinal Tract and Providing Enhanced Therapeutic Activity - A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a NSAID-containing formulation that possess low gastrointestinal (GI) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulsion for internal, oral, direct or topical administration. | 03-17-2011 |
| 20110065207 | COMBINATORIAL MULTIDOMAIN MESOPOROUS CHIPS AND A METHOD FOR FRACTIONATION, STABILIZATION, AND STORAGE OF BIOMOLECULES - A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 μl in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples. The MSC-based device may serve as a diagnostic tool to complement histopathology, imaging, and other conventional clinical techniques. The MSCs mediated identification of disease-specific protein signatures may help in the selection of personalized therapeutic combinations, in the real-time assessment of therapeutic efficacy and toxicity, and in the rational modulation of therapy based on the changes in the protein networks associated with the prognosis and the drug resistance of the disease. | 03-17-2011 |
| 20110064664 | METHODS AND COMPOSITIONS INVOLVING CHITOSAN NANOPARTICLES - Disclosed are nanoparticles for the delivery of a therapeutic agent or a diagnostic agent to a subject that include a chitosan and a polyphosphate, wherein the weight ratio of the chitosan to the polyphosphate is about 1.0 or greater and the weight ratio of the polyphosphate to the therapeutic agent or diagnostic agent is about 15.0 or less. Also disclosed are nanoparticles that include a chitosan and an inhibitor of enhancer of Zeste homologue 2 (EZH2). Methods of delivering a therapeutic agent or a diagnostic agent to a subject for the treatment or prevention of a disease and methods of predicting prognosis of ovarian cancer in a subject that involve determining the expression and/or function of EZH2 in the subject are also disclosed. | 03-17-2011 |
| 20110034568 | Compositions comprising lecithin oils and NSAIDS for protecting the gastrointestinal tract and providing enhanced therapeutic activity - A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a NSAID-containing formulation that possess low gastrointestinal (GI) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulstion for internal, oral, direct or topical administration. | 02-10-2011 |
| 20110021805 | COMPOUNDS FOR TREATMENT OF CELL PROLIFERATIVE DISEASES - The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines. | 01-27-2011 |
| 20100320549 | Methods and Apparatuses for Integrated Packaging of Microelectromechanical Devices - Microelectromechanical systems (MEMS) packages, packaged MEMS devices, and methods for making the same are disclosed. The method may include forming a chamber sacrificial layer above an insulating layer that is coupled to a wafer. The method further may include forming a packaging layer above the chamber sacrificial layer. The method additionally may include forming one or more openings through the packaging layer. The method also may include removing the chamber sacrificial layer through the one or more openings. The method may include forming a sealing layer above the packaging layer such that the sealing layer substantially seals the one or more openings to form a hermetic cavity. | 12-23-2010 |
| 20100316590 | COMPOSITIONS AND METHODS RELATED TO POLOXAMER COPOLYMER MEMBRANE SEALANT - Embodiments of the invention include the treatment of amyloid oligomer toxicity by administering a membrane sealant co-polymer, for example poloxamer 188 (P188). | 12-16-2010 |
| 20100311601 | INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES - The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine therapy or chemotherapy. | 12-09-2010 |
| 20100303835 | PEPTOID LIGANDS FOR ISOLATION AND TREATMENT OF AUTOIMMUNE T-CELLS - The present invention provides for the identification of autoreactive T cell populations from individuals having autoimmune diseases, such as multiple sclerosis and EAE. Peptoids recognized by autoreactive T cells can be used to identify various types of autoimmune disease, and can also be used to target therapies against such populations. | 12-02-2010 |
| 20100303805 | IDENTIFICATION OF SMALL MOLECULES RECOGNIZED BY ANTIBODIES IN SUBJECTS WITH NEURODEGENERATIVE DISEASES - The present invention provides for the identification of individuals having neurodegenerative diseases (ND). Peptoids recognized by Parkinson's Disease- and Alzheimer's Disease-specific antibodies are identified, allowing one to diagnose or predict ND in subjects. | 12-02-2010 |
| 20100292229 | TRYPHOSTIN-ANALOGS FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES - The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. In general aspects, compounds of the present invention are tyrphostin-like in structure. Compounds of the present invention, in certain embodiments, display significant potency by causing, for example, inhibition of Stat3 activation, reduction in c-myc protein levels and/or induction of apoptosis in tumor cells. In general aspects, compounds of the present invention induce one or more of these activities at nanomolar concentrations and typically function through a unique mechanism involving the induction of stress granules that bind specific signaling molecules and prevent them from participating in signal transduction and oncogenesis. | 11-18-2010 |
| 20100291588 | SYSTEMS AND METHODS INCLUDING SELF-CONTAINED CARTRIDGES WITH DETECTION SYSTEMS AND FLUID DELIVERY SYSTEMS - Methods, systems, and apparatus for detecting the presence of analytes are described. A fluid or gas sample may pass through a microsieve-based detection system and/or a particle-based detection system of a cartridge. Detection and analysis techniques may be applied to determine the identity and quantity of the captured analytes. | 11-18-2010 |
| 20100227006 | POWDER MIX OF POTASSIUM CALCIUM CITRATE FOR THE TREATMENT OF KIDNEY STONES AND OSTEOPOROSIS - A composition comprising a powder mixture of potassium citrate and calcium citrate as mixtures of pure chemical salts and methods of making and using the composition are disclosed. The composition is useful for the treatment and prevention of kidney stones and osteoporosis and better delivers potassium and calcium than commonly used potassium and calcium supplements. | 09-09-2010 |
| 20100221761 | MEASURING CIRCULATING THERAPEUTIC ANTIBODY, ANTIGEN AND ANTIGEN/ANTIBODY COMPLEXES USING ELISA ASSAYS - The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease. | 09-02-2010 |
| 20100220010 | Method and apparatus for beam-forming signal in multi user-MIMO wireless communication system - A base station is capable of transmitting a signal in a wireless communication network. The base station decides channel state information matrices of respective channels by determining a state of the channels corresponding to respective transmission antennas. The base station calculates transmission beam forming vectors for the respective transmission antennas by a combination of a dot product and a cross product of the channel state information matrices. Thereafter, the base station beam-forms signals for the respective transmission antennas by using the respective transmission beam forming vectors, and transmitting the beam-formed signals. | 09-02-2010 |
| 20100184964 | PREPARATIONS OF PHOSPHOLIPIDS AND PHARMACEUTICALS CONTAINING 5-AMINO SALICYLIC ACID FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE - A unique composition of a 5-amino salicylic acid (5ASA) and a phospholipid is disclosed for treating Inflammatory Bowel Disease (IBD), where the composition can be a mixture, a molecular association complex or a covalent compound of 5ASA and a reactive phospholipid covalently bonded together via a diazo linkage and to methods for administering the compositions to treat symptoms of IBD. | 07-22-2010 |
| 20100179213 | Methods and Compositions Involving miRNAs In Cancer Stem Cells - The present invention concerns methods and compositions for treating a patient having, suspected of having, or at risk of developing cancer by targeting cancer stem cells. | 07-15-2010 |
| 20100177839 | METHOD OF DIRTY PAPER CODING USING NESTED LATTICE CODES - A method of Dirty Paper Coding DPC using nested lattices is disclosed. The complexity of DPC can be reduced by scaling nested lattices and mapping interference to a lattice point of the scaled lattice. | 07-15-2010 |
| 20100173876 | OIL-BASED NSAID COMPOSITIONS AND METHODS FOR MAKING AND USING SAME - A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a NSAID-containing formulation that possess low gastrointestinal (GI) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulsion for internal, oral, direct or topical administration. | 07-08-2010 |
| 20100173289 | Methods for Assessing Cancer Susceptibility to Carcinogens in Tobacco Products - The present invention demonstrates the differential sensitivity of PBLs from lung cancer patients and healthy controls to NNK-induced genetic damage. The data provide convincing evidence that the preferred CBMN assay is a robust test for detection of this sensitivity and yields results that are a good predictor of, for example, lung cancer risk. The simplicity, rapidity, and sensitivity of the CBMN test make it a valuable tool for screening and, for example, prioritizing potential cases for early detection of the disease. | 07-08-2010 |
| 20100172962 | THERAPEUTIC TARGETING OF INTERLEUKINS USING SIRNA IN NEUTRAL LIPOSOMES - The present invention relates to the fields of molecular biology and drug delivery. In certain embodiments, the present invention provides compositions that include an siRNA targeted to an interleukin and a neutral lipid, and methods of treating a human subject with cancer involving administering to the subject a pharmaceutically effective amount of an interleukin-8 antagonist or a composition as set forth herein. | 07-08-2010 |
| 20100172922 | Expression and Purification of HIP/PAP and Uses Therefor - The present invention relates to methods of compositions comprising RegIII and HIP/PAP proteins, including the use of such proteins as diagnostic and therapeutic targets. | 07-08-2010 |
| 20100165337 | Customizable Spectral Profiles for Filtering - Computer program products comprising tangible computer-readable media having instructions that are executable by a computer to generate a customized spectral profile, which can be used to generate a corresponding filter. The instructions can comprise: generating a trial source spectrum; determining an uncorrected lamp source spectrum; calculating one or more optical indices using the trial source spectrum or the uncorrected lamp source spectrum; and optimizing one or more of the optical indices by varying the trial source spectrum to generate the customized spectral profile. | 07-01-2010 |
| 20100152699 | Nanochanneled Device and Related Methods - A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel. | 06-17-2010 |
| 20100111925 | Compositions of Engineered Human Arginases and Methods for Treating Cancer - Compositions and methods for the treatment of cancer are described, and, more preferably, to the treatment of cancers that do not express, or are otherwise deficient in, argininosuccinate synthetase, with enzymes that deplete L-Arginine in serum. In one embodiment, the present invention contemplates an arginase protein, such as a human Arginase I protein, comprising at least one amino acid substitution and a metal cofactor, said protein comprising an increased catalytic activity when compared with a native human Arginase I. | 05-06-2010 |
| 20100104511 | METHODS AND COMPOSITIONS USING CHELATOR-ANTIBODY CONJUGATES - Disclosed are pharmaceutical compositions that include a chelator and an antibody directed against a phosphorylation site of a protein, wherein the antibody is conjugated to the chelator to form a chelator-antibody conjugate. For example, the antibody may recognize a phosphorylated tyrosine residue or a phosphorylated serine residue of a cell surface receptor. Also disclosed are methods of synthesizing a radiolabeled chelator-antibody conjugate, wherein the antibody is directed against a phosphorylation site of a protein. Also disclosed are methods for imaging a site in a subject that involve administering to the subject an effective amount of a composition that includes a valent metal ion-labeled chelator-antibody conjugate, wherein the antibody is an antibody directed against a phosphorylation site of a protein, and detecting a radioactive signal from the site in the subject following administration of an effective amount of the composition. The method of imaging can be applied in diagnosing a tumor, such as a tumor that can be responsive to therapy using a tyrosine kinase inhibitor, and in the treatment of a tumor, such as by targeting therapy to cell surface receptors that include phosphorylation sites. | 04-29-2010 |
| 20100092396 | HYPERPOLARIZED 89-YTTRIUM AND METHODS RELATING THERETO - The present invention relates to the preparation of hyperpolarized | 04-15-2010 |
| 20100084273 | Method and Apparatus for Programmable Fluidic Processing - A method and apparatus for microfluidic processing by programmably manipulating a packet. A material is introduced onto a reaction surface and compartmentalized to form a packet. A position of the packet is sensed with a position sensor. A programmable manipulation force is applied to the packet at the position. The programmable manipulation force is adjustable according to packet position by a controller. The packet is programmably moved according to the programmable manipulation force along arbitrarily chosen paths. | 04-08-2010 |
| 20100044210 | METHOD OF DIGESTING CELLULOSE TO GLUCOSE USING SALTS AND MICROWAVE (muWAVE) ENERGY - A method for digesting biomass carbohydrate polymers is disclosed. The method includes irradiating the polymers in an acid/salt solution in the presence of a microwave energy field, where the acid, salt and microwave energy are sufficient to convert a desired amount of the polymers into useful platform chemicals. | 02-25-2010 |
| 20090299469 | CONE-SHAPED AORTIC ROOT REPLACEMENT GRAFT AND METHODS FOR MAKING AND USING SAME - A new aortic root replacement graft or apparatus is disclosed and method for making and using same. The graft or apparatus includes a substantially straight and uniform cylindrical conduit having an outwardly flared end section so that a diameter of the cylindrical section is less than a diameter of a distal end of the flared end section. | 12-03-2009 |
| 20090252250 | APPARATUS AND METHOD FOR BEAMFORMING BASED ON GENERALIZED EIGEN-ANALYSIS IN MULTIPLE INPUT MULTIPLE OUTPUT WIRELESS COMMUNICATION SYSTEM - An apparatus and method for beamforming in a Multiple Input Multiple Output (MIMO) wireless communication system are provided. A Base Station (BS) includes a calculator for generating relational expressions between beamforming vectors of Mobile Stations (MSs) using channel information of each MS, for determining beamforming vector candidates of each MS from the relational expressions using generalized Eigen-analysis, and for selecting beamforming vectors for each MS from the beamforming vector candidates, and a plurality of Transmit (Tx) beamformers for performing Tx beamforming on dedicated pilot symbols to be transmitted to each MS using the beamforming vectors for each MS. | 10-08-2009 |
| 20090156548 | FLUOROCYTIDINE DERIVATIVES AND COX-2 INHIBITORS FOR THE TREATMENT OF CANCER - The present invention provides, in certain embodiments, methods for the treatment of colorectal cancer comprising administering a COX-2 inhibitor and fluorocytidine derivative to a human patient. In certain embodiments, a radiation therapy is also administered to the patient. | 06-18-2009 |
| 20090148868 | JAB1 AS A PROGNOSTIC MARKER AND A THERAPEUTIC TARGET FOR HUMAN CANCER - Methods of diagnosing and prognosticating the development of human cancers, such as breast cancer, colon cancer, and pancreatic cancer, are provided. The diagnostic and prognostic methods include the detection and/or quantifying of the amount of expression of JAB1 in human cells, particularly in relation to the amount of p27 or c-Jun. In addition, methods for reducing the expression of JAB1 protein in cells and inhibiting its interaction with p27 or c-Jun, for example, are provided. | 06-11-2009 |
| 20090082304 | Methods of Treating Hematological Malignancies with Nucleoside Analog Drugs - The present invention provides methods of treating hematological malignancies, including multi-drug resistant malignancies, with 8-amino-adenosine and variants thereof. Also encompassed by the present invention is a method of predicting the response of a patient diagnosed with a hematological malignancy to treatment with a nucleoside analog and a method of screening candidate drugs for efficacy in treating hematological malignancies. | 03-26-2009 |
| 20090062179 | Diagnosing and Treating Hormone Resistant Cancers - Provided herein are methods and compositions related to diagnosing and treating hormone resistant cancers. | 03-05-2009 |
| 20080262433 | INTRATHECAL INJECTION GUIDE APPARATUS AND METHODS FOR MAKING AND USING SAME - An intrathecal injection apparatus is disclosed for use with small animals. The apparatus includes an animal conforming member and a guide tube for inserting a needle and directing the needle so that it properly penetrates the spinal sack of the animal. | 10-23-2008 |
| 20080221579 | APPARATUS TO TRACE AND CUT A TENDON OR OTHER LATERALLY EXTENDED ANATOMICAL STRUCTURE - A harvesting apparatus is disclosed for harvesting anatomical structures such as tendons, fine muscles, nerves and blood vessels, where the apparatus includes an elongate member having two longitudinally extending tubes or tubular apertures extending from the member's proximal end to its distal end. The distal end includes opposing heads and an arcuate base. The anatomical structure is placed on the arcuate base and a flexible cutting member is threaded through one tube over the anatomical structure and into and through the other tube. The elongate member is then directed into an animal or human body along the structure to a position where the anatomical structure is to be cut. Then the cutting member is pulled back and forth at the distal end causing into to cut the anatomical structure at the distal head. | 09-11-2008 |
