Texas Christian University Patent applications |
Patent application number | Title | Published |
20140303394 | Synthesis of H-Phosphonate Intermediates and Their Use in Preparing the Herbicide Glyphosate - The esterfication of hypophosphorous acid is followed by reaction with another molecule of alcohol under the action of a nickel catalyst to provide a green method for the preparation of H-phosphonate diesters. This method avoids the need for any stoichiometric chlorine unlike those based on phosphorous trichloride. | 10-09-2014 |
20140206862 | Antioxidant Small Molecules Aimed at Targeting Metal-Based Oxidative Stress in Neurogenerative Disorders - Amine chelates capable of antioxidant capacity and amyloid disaggregation are shown which may be useful in targeting metal-based oxidative stress in neurodegenerative disorders. Pyclen, a backbone commonly investigated for contrast agent imaging, may be repurposed as an anti-oxidant chelator for disaggregating amyloid. The antioxidant capacity of pyclen is enhanced dramatically via conversion of the pyridine backbone to a pyridol with cellular studies showing superior antioxidant capacity while retaining chelation ability to protect amyloid from metal ions aggregation and also disaggregate amyloid aggregates. Another family of molecules based upon hybrid heterocyclic amine ligands is also presented. | 07-24-2014 |