| TETRALOGIC PHARMACEUTICALS CORPORATION Patent applications |
| Patent application number | Title | Published |
|---|
| 20110305777 | DIMERIC IAP ANTAGONISTS - Smac mimetics that inhibit IAPs. | 12-15-2011 |
| 20110294827 | IAP BINDING COMPOUNDS - IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a K | 12-01-2011 |
| 20110003877 | SMAC Mimetic - A SMAC mimetic and pharmaceutical compositions thereof and methods of use. | 01-06-2011 |
| 20100144650 | DIMERIC IAP INHIBITORS - Compounds, compositions, and methods of using such compounds to modulate apoptosis including IAP antagonists are provided herein. Compositions including mimetics of the invention and, optionally, secondary agents, may be used to treat proliferative disorders such as, cancer and autoimmune diseases. | 06-10-2010 |
| 20100143499 | DIMERIC IAP INHIBITORS - Compounds, compositions, and methods of using such compounds to modulate apoptosis including IAP antagonists are provided herein. Compositions including mimetics of the invention and, optionally, secondary agents, may be used to treat proliferative disorders such as, cancer and autoimmune diseases. | 06-10-2010 |
| 20100113326 | DIMERIC IAP INHIBITORS - Compounds made up of a homodimer or heterodimer having monomeric units of formula (I): wherein: each A is, independently, NR | 05-06-2010 |
| 20100075911 | DIMERIC IAP INHIBITORS - Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inhibitors, NSAIDs, taxanes and platinum containing compounds use broader language | 03-25-2010 |
| 20100056495 | DIMERIC IAP INHIBITORS - Compounds, compositions, and methods of using such compounds to modulate apoptosis including IAP antagonists are provided herein. Compositions including mimetics of the invention and, optionally, secondary agents, may be used to treat proliferative disorders such as, cancer and autoimmune diseases. | 03-04-2010 |
| 20090048183 | IAP BINDING COMPOUNDS - IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a K | 02-19-2009 |
