| Temple University of the Commonwealth System of Higher Education Patent applications |
| Patent application number | Title | Published |
|---|
| 20120122987 | TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35) - Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation. | 05-17-2012 |
| 20120108504 | LEPTIN AGONIST AND METHODS OF USE - Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, type II diabetes, appetite control after bariatric surgery, insulin resistance, lipodystrophy and hypothalamic amenorrhea, obesity-related infertility, among other diseases and conditions related to leptin deficiency and/or leptin resistance. | 05-03-2012 |
| 20120024044 | SYSTEMS AND METHODS FOR DETECTING CONCEALED NUCLEAR MATERIAL - Methods and systems for detecting nuclear material concealed within an enclosure are provided. An ionized air density is measured at one or more locations outside of the enclosure. The presence of the concealed nuclear material is detected, for each of the one or more locations, based on a characteristic of the measured ionized air density indicative of concealed nuclear materials. | 02-02-2012 |
| 20120021130 | METHOD FOR INHIBITING DECOMPOSITION OF METAL SULFIDE-CONTAINING MATERIAL - This invention provides methods of producing a crosslinked lipid coating on a metal sulfide-containing material using a chemical initiator. The crosslinked lipid coating attached to the surface of the material prevents dissolution or oxidation of the material. The methods may be useful to prevent oxidation and leaking of sulfide-containing material in the environment and may be used in the control of environmental pollution. | 01-26-2012 |
| 20120017467 | ORTHOTIC SHOE AND INSOLE ASSEMBLIES - An orthotic shoe sole assembly and an orthotic insole are disclosed herein. The orthotic shoe assembly includes a shoe sole having an exposed surface and at least one exposed cavity accessible via the exposed surface. The at least one exposed cavity includes a central region and a plurality of channels extending from the central region. A resilient member is removably positioned within the central region of the exposed cavity. The resilient member is configured to resiliently expand into at least one of the plurality of channels of the exposed cavity. The orthotic insole is removably positioned to selectively conceal the exposed cavity of the shoe sole and the resilient member. The orthotic insole includes a central axis member for supporting a foot along its central axis. | 01-26-2012 |
| 20110294698 | PROCESS FOR IDENTIFYING DRUGS FOR TREATING GASTROESOPHAGEAL REFLUX - Methods for identifying modulators of gastroesophageal smooth muscle relaxation include isolating various types of smooth muscle fibers from the stomach or esophagus and inducing the fibers to contract. The isolated and contracted fibers are used to screen test compounds for the compound's capacity to modulate relaxation of the smooth muscle fibers. In addition, newly identified unique nicotinic acetylcholine receptors are expressed in a cell, and used to screen test compounds for the compound's capacity to modulate the biological activity of the receptors. | 12-01-2011 |
| 20110288021 | ADMINISTRATION OF ANGIOCIDIN FOR THE TREATMENT OF CANCER - Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest and/or apoptosis of tumor cells, as well as inducing differentiation of tumor cells to inhibit tumorigenicity and to confer a non-tumor or healthy phenotype. | 11-24-2011 |
| 20110274611 | PURIFICATION OF SINGLE WALLED CARBON NANOTUBES BY DYNAMIC ANNEALING - A method for removing impurities from carbon nanotubes is described. Impurities may be removed from the carbon nanotubes by exposing the carbon nanotubes to a temperature, and controlling the temperature such that the temperature is constantly increasing to remove at least a portion of the impurities from the carbon nanotubes. | 11-10-2011 |
| 20110251614 | LOCKING ROD FUSION DEVICE - A locking rod fusion device and method uses internal locking rods and screws that will lock together. In particular, the device allows the insertion of multiple locking rods in combination with a plate, which requires less dissection and disruption of soft tissues and vasculature. The device also provides a more stable internal construct for fusions that prevent non-unions, hardware failure and reoccurrence of deformities, such as Charcot foot. The device combines the strength of locking technology and the utility and ease of an internal rod system to provide a single stable construct in multiple planes as apposed to using multiple plates or screws separately. | 10-13-2011 |
| 20110184171 | ACYLATION OF HINDERED AMINES AND FUNCTIONALIZED BIS-PEPTIDES OBTAINED THEREBY - Functionalized bis-peptides as well as other amide-containing compounds are obtained by acylation of hindered amines. The functionalized bis-peptides are useful as shape-programmable nanostructures that are immune to denaturation and that contain arrays of functional groups having designed catalytic, protein-binding and/or sensor capabilities. | 07-28-2011 |
| 20110162646 | PROCESS FOR TRANSIENT AND STEADY STATE DELIVERY OF BIOLOGICAL AGENTS TO THE LUNG VIA BREATHABLE LIQUIDS - The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering a biological agent in a breathable liquid to a lung of a patient. The steps of both the transient delivery method and the steady state delivery method can be controlled by a servo-control unit. A supplementary biological agent delivery step can be performed in both the transient method of delivering a biological agent and the steady state method of delivering a biological agent. | 07-07-2011 |
| 20100321767 | METHODS AND DEVICES FOR GENERATION OF BROADBAND PULSED RADIATION - Methods and apparatus for non-collinear optical parametric ampliffication (NOPA) are provided. Broadband phase matching is achieved with a non-collinear geometry and a divergent signal seed to provide bandwidth gain. A chirp may be introduced into the pump pulse such that the white light seed is amplified in a broad spectral region. | 12-23-2010 |
| 20100305059 | COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA - Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: | 12-02-2010 |
| 20100291595 | BLOOD MONOCYTE CD163 EXPRESSION AS A BIOMARKER IN HIV-1 INFECTION AND NEUROAIDS - The invention provides a method for detecting CD163+/CD16+ cell population in peripheral blood mononuclear cells in a biological sample from a subject infected with HIV-1 which comprises contacting the biological sample with an anti-CD163 antibody, so that levels of CD163+/CD16+ peripheral blood mononuclear cells in the biological sample can be quantified. The method of the present invention is particularly useful for monitoring the course of HIV-1 infection and/or HIV Encephalopathy | 11-18-2010 |
| 20100284921 | TARGETED NANOPARTICLES FOR INTRACELLULAR CANCER THERAPY - This invention provides constructs comprising a targeting member immobilized on a detectable particulate, in which binding of the targeting member to a target structure on a surface of a cancer cell triggers internalization of the construct. Such constructs can be used to identify or monitor cancer cells in cell cultures or in a tissue. Such construct can also be used to kill or prevent growth of cancer cells in vivo. Also included in the invention are methods for killing or preventing growth of cancer cells in vivo. | 11-11-2010 |
| 20100204673 | OBESITY CONTROLLING METHOD - A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding stomach emptying and producing a feeling of satiation in the patient. The method may be supplemental and augmented by inducing flacid paralysis of the stomach by injecting botulinum toxin into the muscle tissue of the antrum or fundus of the stomach. | 08-12-2010 |
| 20100136036 | UNCONVENTIONAL ANTIGEN TRANSLATED BY A NOVEL INTERNAL RIBOSOME ENTRY SITE ELICITS ANTITUMOR HUMORAL IMMUNE REACTIONS - The invention provides a novel antigen, MPD6, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3′ untranslated region (3′UTR) of myotrophin mRNA. MPD6 elicits IgG antibody responses in a subset of PV patients, as well as patients with chronic myelogenous leukemia and prostate cancer. The translation of MPD6 was mediated by a novel internal ribosome entry site (IRES) upstream of the MPD6 reading frame. Furthermore, the MPD6-IRES mediated translation, but not myotrophin-MPD6 transcription, was significantly upregulated in response to IFN-α stimulation. These findings demonstrate that a novel IRES-mediated mechanism is responsible for the translation of unconventional self-antigen MPD6 in responsive to IFN-α stimulation. The eliciting anti-tumor immune response against unconventional antigen MPD6 in patients with myeloproliferative diseases indicates MPD6 as a target of novel immunotherapy. | 06-03-2010 |
| 20100036395 | METHOD AND APPARATUS OF ENDOSCOPIC SUTURING - An adjustable suture assembly is provided that may be employed in various surgical procedures to draw and/or hold tissue and/or muscle together. The suture assembly may include a suture lock or tensioner that is adjustably securable to two or more lengths of suture to provide a surgeon with an ability to maintain tissue or muscle in one secured position and subsequently readjust the suture assembly to maintain the tissue or muscle in a different secured position. The suture assembly may include two or more sutures having an anchor attached to an end of each suture for anchoring the suture to desired tissue or muscle. An endoscopic suturing device is provided to deliver and place two or more sutures in tissue or muscle during a surgical procedure. The suturing device may be configured to carry a plurality of sutures so that multiple sutures can be placed in tissue or muscle during a single intubation of the device. The suture assembly and suturing device may be employed with an endoscope to facilitate surgical treatment of obesity which involves narrowing and/or disabling the pyloric sphincter to reduce the rate of gastric emptying. | 02-11-2010 |
| 20100028368 | SULFIDE, SULFOXIDE AND SULFONE CHALCONE ANALOGUES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF - Compounds useful as antiproliferative agents according to formula (I): wherein Ar | 02-04-2010 |
| 20100024783 | ELECTRIC-FIELD ASSISTED FUEL ATOMIZATION SYSTEM AND METHODS OF USE - An apparatus ( | 02-04-2010 |
| 20100012122 | OPEN-CIRCUIT LIQUID VENTILATOR - An open-circuit liquid ventilation system includes a reservoir containing a breathable liquid, a patient interface receiving breathable liquid from the reservoir, a pump directing breathable liquid from the reservoir to the patient, a controller for the pump, and a tank for storing used breathable liquid. The system may be passive regarding expired liquid. Alternatively, the system may be active and include a bypass line connected to the pump such that used breathable liquid is drawn from the patient. The patient interface may be adapted to interface a gas ventilation system to facilitate a rapid conversion from gas to liquid ventilation. The system may include sensors monitoring pressure and volume parameters and may include an output displaying information including schematics and real time tracings regarding a ventilation procedure. | 01-21-2010 |
| 20090304736 | NOVEL TUMOR ANTIGENS ELICIT ANTI-TUMOR HUMORAL IMMUNE REACTIONS IN A SUBSET OF PATIENTS WITH POLYCYTHEMIA VERA - The invention provides novel antigens, MPD5, PV13, and PV65, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3′untranslated region (3′UTR) of myotrophin mRNA. The antigens elicit IgG antibody responses in a subset of PV patients, as well as patients with chronic myelogenous leukemia and prostate cancer. The translation of MPD5, PV13 and PV65 was mediated by a novel internal ribosome entry site (IRES) upstream of the open reading frame. Eliciting anti-tumor immune response against MPD5, PV13 and/or PV65 antigen in patients with myeloproliferative diseases is a novel immunotherapy. | 12-10-2009 |
| 20090281066 | Treatment of proliferative disorders with amino-substituted (E)-2,6- dialkoxystyryl 4-substituted benzylsulfones - Methods of treating cancer using compounds according to Formula (I) are disclosed herein, wherein X, X | 11-12-2009 |
| 20090275650 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof - Compounds of Formula I: | 11-05-2009 |
| 20090191193 | Aryl Vinyl Sulfides, Sulfones, Sulfoxides and Sulfonamides, Derivatives Thereof and Therapeutic Uses Thereof - Compounds useful as antiproliferative agents, including, for example, anticancer agents, according to formula I: | 07-30-2009 |
| 20090138979 | MANIPULATING SP1 ACTIVITY TO IMPROVE THERAPEUTIC CLONING - The observed over-expression of Sp1 target genes has inspired inventors to formulate a specific strategy for correcting many gene expression defects, and thus improve clone development. The invention is based on the belief that manipulating Sp1 activity can improve cloning. Inventors believe that cloning is inefficient in large part because of the continued expression of Sp1 target genes in the early cloned embryos, which causes clones to be very unlike normal embryos, and so makes them very unhealthy. Inventors propose that if over-expression of Sp1 target genes is prevented in early stage clones, this would greatly improve cloning efficiency by making the cloned embryos healthy again. | 05-28-2009 |
| 20090124828 | Unsaturated Sulfides, Sulfones, Sulfoxides and Sulfonamides Synthesis - α,β-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula I: | 05-14-2009 |
