| TECHNISCHE UNIVERSITAET DRESDEN Patent applications |
| Patent application number | Title | Published |
|---|
| 20120003684 | Method and Means for Detecting the Activity of Osteoclasts - The invention relates to a method and means for detecting the resorption activity of osteoclasts, in particular for use in medicine and in bioscience and pharmaceutical research. Previous methods for measuring the resorption activity of osteoclasts in vitro are difficult to quantify, are partially inflexible when used with different donor organisms and require special measuring devices for data acquisition. The method and kit according to the invention advantageously use a biomineralized matrix which contains calcium phosphate and was obtained in vitro by depositing calcium phosphate by means of osteoblasts. Osteoclasts are incubated on this matrix and the non-resorbed calcium phosphate is then quantified. The method according to the invention advantageously functions with osteoclasts of different organisms and cell types and can be easily quantified. | 01-05-2012 |
| 20110256579 | Method for Verifying and/or Identifying Hormonally Effective Substances - The invention relates to a method for verifying and/or identifying hormonally effective substances using the pheromone system of yeast, to yeast cells for carrying out the method, and to the use thereof. The method according to the invention comprises the following steps: a) adding yeast culture medium or buffer to a sample which presumably contains a hormonally effective substance, b) thereafter contacting the sample with haploid yeast cells that possess features 1 through 3: 1. the DNA sequence coded for a heterologous hormone receptor is placed under the control of a constitutive promoter, 2. the DNA sequence coded for a yeast pheromone is placed under the control of a promoter that can be regulated by the hormone receptor, 3. a gene that is coded for a receptor for the yeast pheromone is constitutively expressed, wherein the activation of the hormone receptor by the hormonally effective substance leads to the expression and secretion of the yeast pheromone, and c) the physiological and/or morphological changes of haploid yeast cells are detected. | 10-20-2011 |
| 20110237552 | Composite Material Consisting of a Collagen Matrix Mineralised with Silicate and Calcium Phosphate Phases, Method for the Production and Use Thereof - The invention relates to novel composite materials based on a collagen matrix mineralised with silicate and calcium phosphate phases, to a method for the production thereof and use thereof as an implant material which can be shaped in a plurality of ways, a biological coating or active substance carrier. The claimed composite material comprises a collagen matrix which is mineralised with silicate and a calcium phosphate phase, said collagen being a recombinate collagen, collagen from Eumetazoa, sponge collagen from a sponge of the Demospongia class (horn sponges) or Calcarea (calcareous sponges), a synthetic collage analogue, a collagen derivative or a mixture of said collagens. | 09-29-2011 |
| 20110233573 | Method for Producing Temperature-Stable Large-Size Emitting LEDs and LEDs - The invention relates to a method for producing temperature-stable large-size emitting LEDs and LEDs produced by said method. The method is characterised in that a large-area emitting light emitter is provided in the form of semiconductor nanocrystals which furthermore is temperature-stable and has a narrow band emission. A colloidal solution of emitting nanocrystals and a matrix of either inorganic gels or at least one polymer are alternately applied to the substrate with the first electrode by spraying, as a result of the electrostatic interactions between substrate, nanoparticles and inorganic gels or polymers, the nanopartides or the polymers of the matrix are adsorbed and the impurities run down with the solvent. The layer of alternately sprayed nanocrystals and matrix are heated to give a gel cross-linking the metal oxide nanoparticles, wherein thee size of thee semiconductor nanocrystals which determine the emission wavelength are determined by the temperature and duration of the heating. The second electrode is then applied by means of a conventional PVD method. | 09-29-2011 |
| 20110189657 | Device and a Method for the Detection and Amplification of a Signal - The invention relates to a device and a method for the detection and amplification of a primary signal, utilizing an intracellular communication system, and the use thereof for the detection of substances such as phosphorus, sulfur, nitrogen, hormones, metabolic intermediates, fermentation products, and so forth. The device according to the invention for the detection and amplification of a primary signal contains cells of a first type for which a gene, which is responsible for the synthesis of a signal molecule, is under the control of a promoter which is regulated by the primary signal, and cells of a second type for which a specific gene is under the control of a promoter which is regulated by the separated signal molecule, in such a way that the secretion of the signal molecule is induced by a primary signal taken up by a cell of the first type, and the primary signal is amplified by the cells of the second type by the expression of the specific gene under the control of the signal molecule. | 08-04-2011 |
| 20110189289 | Cell-Based Method and Means for Rebuilding Bone - The invention relates to the use of in vitro isolated or in vitro differentiated osteoclasts for bone rebuilding, in particular by in vivo application, to trigger bone rebuilding by attracting osteoblasts and preferably also vascular cells to sites of bone defect. It has been found by the inventors that osteoclasts can control bone rebuilding by secreting chemotactic factors and attracting osteoblasts and vascular cells to a site of bone defect. The invention further relates to the use of osteoclasts for the manufacture of a pharmaceutical preparation or medical product containing osteoclasts for the use for bone rebuilding. | 08-04-2011 |
| 20110115130 | IMPRINT TEMPLATE, NANOIMPRINT DEVICE AND NANOSTRUCTURING METHOD - Imprint templates for use in nanoimprint lithography methods, a nanoimprint device suitable for UV nanoimprint lithography methods and a nanostructuring method for direct structuring of a UV-sensitive imprint material on a substrate are provided. The imprint templates, nanoimprint device and nanostructuring method can be used both for ultraviolet nanoimprint lithography and for thermal nanoimprint lithography. The imprint template includes a nontransparent structured chip and a transparent substrate. An at least partially nontransparent imprint template as well as a UV source situated above the imprint template holder are used for structuring by indirect exposure by reflection of light emitted from the UV radiation source in the direction of a photoactive layer. | 05-19-2011 |
| 20110105761 | Salts Comprising Aryl-Alkyl-Substituted Imidazolium and Triazolium Cations and the Use Thereof - The present invention relates to salts comprising novel aryl-alkyl-substituted imidazolium and triazolium cations and arbitrary anions. The invention further relates to methods for the chemical conversion and separation of substances, comprising the salts according to the invention as solvents, solvent additives, or extraction means, and to the use of the salts according to the invention, for example as solvents or solvent additives in chemical reactions, as extracting agents for the separation of substances, or for storing hydrogen. According to the invention, the object is achieved by salts of the general formula (I), where X— is an anion, Y1 and Y2 are CH, or Y1 is CH and Y2 is N, or Y1 is N and Y2 is CH, n is a number from 1 up to an including 18, Q is selected from —CH3, —OH, —ORx, —S03H, —S03Rx, —COOH, —COORx, —CORx, NH2, —NHRx, —N(Rx)2, and —CH(Rx)2, Z is H or Rx, R1, R2, R3, R4 and R5 independently from each other are —H, -halogen, —N02, —NH2, —NHRx, —N(Rx)2, —Rx, —COORx or —ORx, where Rx is an optionally substituted and/or branched C1 to C18-alkyl group, excluding compounds of the general formula (I), where Y1 and Y2 are CH and R1, R2, R3, R4 and R5 are H, excluding compounds of the general formula (I), where Y1 and Y2 are CH, R1=R3=R5=CH3 is true, n=1, 2, 6 and Q=CH3 is true, excluding compounds of the general formula (I), where Y1 is CH and Y2 is N, R1, R2, R3, R4 and R5 are H, n=1 is true, and Q=CH3 is true, and excluding compounds of the general formula (I), where Y1 and Y2 are CH, R1, R2, R4, R5=H is true, R3=ORx is true, and Rx is a hydrocarbon having 3 or 12 carbon atoms. | 05-05-2011 |
| 20110097338 | Use of Substances for Sensitization of Tumor Cells to Radiation and/or Chemotherapy - The invention relates to the use of substances to increase the sensitivity of tumor cells to treatment with radiation and/or chemotherapy. This is accomplished through the use of substances which block or limit the function of the PINCH-1 protein for sensitization of tumor cells to radiation and/or chemotherapy. | 04-28-2011 |
| 20100285505 | Device and Method for Detecting a Substance by Means of Particle Plasmon Resonance (PPR) or Particle-Mediated Fluorescence Based on Cell Surface Polarizations - The invention relates to devices and methods for detecting a substance by cell surface polarizations and the detection thereof by means of PPR or particle-mediated fluorescence. The device for detecting a substance by cell surface polarization according to the invention has cells, wherein a gene the expression of which leads to the polarized presentation of a protein on the surface of the cell is placed under the control of a promotor which can be regulated by the substance to be detected, nanoparticles which are functionalized with a molecule which can bind specifically to the surface-exposed protein, and at least one optical measurement device, such that an accumulation of the nanoparticles on the surface of the cells can be detected by particle plasmon resonance or particle-mediated fluorescence. | 11-11-2010 |
| 20100221817 | Whole-Cell Sensor - The invention relates to whole-cell sensors for monitoring bioavailable nitrogen, phosphorus and sulphur, individually or in at least one combination in a medium, and to the use thereof. The whole-cell sensors consist of genetically modified yeast cells which are immobilised in a xerogel matrix and contain at least one marker gene controlled by a promoter of a gene, the transcription of said gene being significantly increased or reduced in the absence of nitrogen, phosphorus or sulphur, and the yeast cells are at least coupled to a signal detector. | 09-02-2010 |
| 20090326237 | USE OF PT-AND PD-BIS-AND TETRA-CARBON COMPLEXES WITH BRIDGED CARBON LIGANDS IN OLEDS - The use of Pt- and Pd-bis- and tetracarbene complexes with bridged carbene ligands in organic light-emitting diodes, organic light-emitting diodes comprising at least one aforementioned Pt- or Pd-carbene complex, at least one transition metal-carbene complex of the general formula I and/or II, organic light-emitting diodes where the at least one transition metal-carbene complex of the general formula I and/or II is present in the light-emitting layer, a blocking layer for electrons, a blocking layer for excitons and/or a blocking layer for holes, a light-emitting layer comprising at least one aforementioned Pt- or Pd-carbene complex, organic light-emitting diodes comprising at least one inventive light-emitting layer, and devices which comprise at least one inventive organic light-emitting diode. | 12-31-2009 |
