| TARGETED MOLECULAR DIAGNOSTICS, LLC Patent applications |
| Patent application number | Title | Published |
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| 20100332417 | METHODS FOR THE DETECTION AND QUANTITATION OF THE P95 COMPONENT OF HER2/NEU (ERBB2) - The present disclosure relates generally to methods for the detection and quantitation of the p95 component of HER2/neu (ERbB2). Such methods may comprise assaying the biological sample for expression of HER2 ICD; assaying the biological sample for expression of a HER2 ECD; quantitating an expressed amount of the HER2 ICD and an expressed amount of the HER2 ECD in the biological sample; and determining the amount of p95 expressed in the biological sample based on a difference between the expressed amount of the HER2 ICD and the expressed amount of the HER2 ECD. The methods of the present disclosure may be used to predict whether a subject will be responsive to a receptor tyrosine kinase inhibitor and/or may be used to select subjects for inclusion/exclusion in a clinical trial. | 12-30-2010 |
| 20100303809 | METHODS FOR THE DETECTION AND QUANTITATION OF PTEN - The present disclosure provides methods for determining if PTEN is elevated or reduced in one or more tumor cells relative to one or more normal cells in the same biological sample by obtaining a biological sample comprising one or more tumor cells and one or more normal cells; assaying the biological sample for expression of PTEN; quantitating an amount of PTEN expression in the one or more tumor cells and an amount of PTEN expression in the one or more normal cells; comparing the amount of PTEN expression in the tumor cells to the amount of PTEN expression in the normal cells; and determining that PTEN is elevated in the tumor cells where the amount of expression of PTEN is greater in the tumor cells as compared to the normal cells or determining that PTEN is reduced in the tumor cells where the amount of expression of PTEN is less in the tumor cells than in the normal cells. Such methods may be used to predict whether a patient will be responsive to treatment with one or more receptor tyrosine kinase inhibitors and/or may be used to select subjects for inclusion/exclusion in a clinical trial. | 12-02-2010 |
| 20100173918 | METHODS AND COMPOSITIONS FOR DETERMINING THE EFFICACY OF BREAST CANCER THERAPEUTICS - The present disclosure relates to a method, kit and controls for detecting phosphorylated Tyr | 07-08-2010 |
| 20090214576 | TYROSINE KINASE INHIBITOR COMPOSITIONS AND METHODS FOR MANUFACTURING AND USING THEM IN THE TREATMENT OF DISEASE - The invention is the method of using the soluble modified receptor erbB3 to treat breast cancer by competitively inhibiting ligands, such as heregulin, from binding to erbB3 tyrosine kinase receptors on cell surfaces. | 08-27-2009 |
| 20090186910 | COMPOSITIONS AND METHODS FOR REDUCING CELLULAR FAT AND FOR PREDICTING CARDIAC TOXICITY AND UPON TREATMENT WITH TYROSINE KINASE INHIBITORS - Methods are disclosed for determining whether organ toxicity, particularly cardiotoxicity, will occur in a patient selected for treatment with various kinase inhibitors, such as tyrosine kinase inhibitors, more particularly erbB inhibitors such as Herceptin. In addition, methods are disclosed for determining whether a potential drug is likely to produce a cardiotoxic effect. The methods involve analyzing lipid levels or the expression fatty acid oxidation enzymes, pAMP activated protein kinase, glucose uptake, to determine whether a fatty acid oxidation disorder is present. The identification of a fatty acid oxidation disorder can be used as a predictor of toxicity, especially cardiac toxicity, and as an indication that organ function should be carefully monitored if a drug such as a tyrosine kinase inhibitor is administered. Methods are also disclosed for protecting organs from metabolic stress and for the treatment of cells, such as adipocytes, to reduce their lipid content. | 07-23-2009 |
