| SYDDANSK UNIVERSITET Patent applications |
| Patent application number | Title | Published |
|---|
| 20120129725 | NUCLEIC ACID NANO-BIOSENSORS - There is provided nanobiosensors and more particularly sensors comprising one or more aptamers or other functional nucleic acids adapted for signalling incorporated within a nanoparticle comprising polyacrylamide or other suitable polymer. Moreover, there is provided a novel DNA aptamer, which selectively binds to ATP. There is also provided a novel nanobiosensor for monitoring ATP concentrations in samples, including biological samples; this new approach may be used to monitor kinase activity in a given sample. | 05-24-2012 |
| 20110283256 | METHOD, COMPUTER PROGRAM PRODUCT, AND SYSTEM FOR NON-BLOCKING DYNAMIC UPDATE OF STATICALLY TYPED CLASS-BASED OBJECT-ORIENTED SOFTWARE - Under the present invention, a method, computer program product, and system for non-blocking dynamic update of statically-typed class-based object-oriented software executing as byte-code on a virtual machine within an actively running computer system is provided. A set of objects instantiated from an existing module or multiple modules (identifiable collections of application resources and class definitions in the form of byte-code representations) is ready for execution on a virtual machine in an actively running computer system. New versions of one or more modules corresponding to those already loaded into the actively running virtual machine are dynamically loaded into the virtual machine for the purpose of updating the running software. The class definitions within the loaded modules are prepared for dynamic update by inserting byte-code that enables; transparent state transfer and shared object identity between objects of a former version and the new version of a class. On the event of a software update, the objects instantiated from a former version of an updated class become un-initialized surrogate objects with the potential to redirect to their future corresponding objects. Corresponding objects are created lazily on first access of the declaring class members. Besides lazy redirection of the behavior of objects and classes, non-blocking dynamic update is achieved by lazy migration of the state of former objects and classes while locking on a temporary field access lock. Thus, the algorithm for controlling field access and state migration is completely lock-free both before and after state migration; hence the performance degradation is minimal. Finally, any unreferenced objects are removed from memory. | 11-17-2011 |
| 20110265192 | NUCLEAR RECEPTOR SENSOR SYSTEM IN TRANSGENIC ANIMAL - A sensor system for detecting the activation of specific nuclear receptors in a tissue of an animal is provided. The nuclear receptor sensor system comprises a sensor component comprising a nuclear receptor or part thereof coupled to a DNA-binding domain, and a reporter component comprising a reporter gene. Transgenic animals, such as a transgenic pig is provided, which comprises the components of the nuclear receptor sensor system in its genome. Also methods of producing the transgenic animal is provided as well as use of the transgenic animal for evaluating the activity of a nuclear receptor in vivo. | 10-27-2011 |
| 20110003396 | EXPLOSIVES DETECTION MARKERS - The present invention relates to a porphyrinogen based sensor having selective binding affinity for an explosive chemical. Upon binding of the target molecule, the porphyrinogen derivative undergoes a detectable adsorption and emission of electromagnetic radiation. | 01-06-2011 |
| 20100144848 | DNA CONTROLLED ASSEMBLY OF LIPID MEMBRANES - The present invention relates to detection of target nucleic acids by target nucleic acid induced liposome assembly. The invention provides oligonucleotides for use in detection and a method of detecting target nucleic acids. Other aspects of the invention are use of the oligonucleotide of the invention for detection, a kit for detection, a method of treatment comprising administrating the oligonucleotide of the invention and a pharmaceutical composition comprising the oligonucleotide of the invention. | 06-10-2010 |
| 20100122356 | PIG MODEL FOR PSORIASIS - The present invention relates to a genetically modified pig as a model for studying psoriasis. The modified pig model displays one or more phenotypes associated with psoriasis. Disclosed is also a modified pig comprising a mutation in the endogenous ILK-I Ra, JunB/cJun, CD18, IKK2, and/or LIG1 gene, and/or a human, porcine and/or murine PPARs, PPAR-δ, lκB-α, STAT3c, Integrin beta 1, Integrin alpha 2, MEK1, Amphiregulin, BMP-6, VEGF, JunBΔec-JunΔep, IL-I a, TGF.beta 1, CD18 hypo, Cre/lkk2FL/FL, Dsg1, SCCE, TGF-a, TNF-a, IL-20, IFN-g, LIG1 KO, KGF, IL-6, PAFR1 Cre/lkk2FL/FL, IL1 R, Dsg3, IFN-gamma, p40, ILI Ra, IKK2, JunB/c-Jun, and/or LIG1 gene, transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of psoriasis, for screening the efficacy of a pharmaceutical composition, and a method for treatment of human being suffering from psoriasis are disclosed. | 05-13-2010 |
| 20090239756 | PREDICTORS FOR METASTASIS OF BREAST CANCER - There is provided a gene expression pattern which is clinically relevant to metastasizing breast cancer. In particular, the identity of genes that are correlated with patient survival and breast cancer recurrence are provided. The gene expression profile, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to predict survival of subjects afflicted with breast cancer and the likelihood of breast cancer recurrence. The invention thus provides for the use of a gene expression pattern (or profile or “signature”) which correlates with (and thus able to discriminate between) patients with good or poor survival outcomes. | 09-24-2009 |
