| Stratos Biosystems, LLC Patent applications |
| Patent application number | Title | Published |
|---|
| 20090215192 | Solid-phase affinity-based method for preparing and manipulating an analyte-containing solution - A method for preparing an analyte-containing solution, which is compatible with surface-tension-directed liquid droplet manipulation and solid-phase affinity-based assays, is disclosed. The method comprises providing an affinity capture surface comprising a substrate surface having a plurality of first and second surface modifiers associated therewith, wherein the first and second surface modifiers render the affinity capture surface wettable and resistant to non-specific protein adsorption, and wherein the second surface modifiers are capable of selectively retaining an analyte, contacting the affinity capture surface with the analyte to form analyte/surface modifier complexes between the analyte and the second surface modifiers, and cleaving the first and second surface modifiers to release terminal portions of the first and second surface modifiers and the analyte into a solution in contact with the affinity capture surface, thereby yielding the analyte-containing solution and generating a hydrophobic surface. Novel affinity capture surfaces and methods for preparing the same are also disclosed. | 08-27-2009 |
| 20090163380 | ANALYTE FOCUSING BIOCHIPS FOR AFFINITY MASS SPECTROMETRY - A novel affinity capture surface, as well as methods of using and making the affinity capture surface and sample presentation devices or biochips comprising the affinity capture surface, are disclosed. The affinity capture surface comprising a substrate surface having adjacent first and second affinity capture zones, wherein the first affinity capture zone comprises a first binary self-assembled monolayer comprising a plurality of affinity capture monomers and hydrophilic-terminated monomers associated with the substrate surface and the second affinity capture zone comprises a second binary self-assembled monolayer comprising a plurality of affinity capture monomers and hydrophobic-terminated monomers associated with the substrate surface, and wherein the affinity capture monomers are capable of selectively retaining an analyte and are cleavable to release terminal portions of the affinity capture monomers and the analyte, thereby generating a hydrophilic surface in the first affinity capture zone and a hydrophobic surface in the second affinity capture zone. | 06-25-2009 |
